keyword
https://read.qxmd.com/read/38536923/lupus-susceptibility-gene-pbx1-controls-the-development-stability-and-function-of-regulatory-t-cells-via-rtkn2-expression
#1
JOURNAL ARTICLE
Seung-Chul Choi, Yuk Pheel Park, Tracoyia Roach, Damian Jimenez, Amanda Fisher, Mojgan Zadeh, Longhuan Ma, Eric S Sobel, Yong Ge, Mansour Mohamadzadeh, Laurence Morel
The maintenance of regulatory T (Treg ) cells critically prevents autoimmunity. Pre-B cell leukemia transcription factor 1 ( Pbx1 ) variants are associated with lupus susceptibility, particularly through the expression of a dominant negative isoform Pbx1-d in CD4+ T cells. Pbx1-d overexpression impaired Treg cell homeostasis and promoted inflammatory CD4+ T cells. Here, we showed a high expression of Pbx1 in human and murine Treg cells, which is decreased in lupus patients and mice. Pbx1 deficiency or Pbx1-d overexpression reduced the number, stability, and suppressive activity of Treg cells, which increased murine responses to immunization and autoimmune induction...
March 29, 2024: Science Advances
https://read.qxmd.com/read/38535787/alleviative-effect-of-rutin-on-zearalenone-induced-reproductive-toxicity-in-male-mice-by-preventing-spermatogenic-cell-apoptosis-and-modulating-gene-expression-in-the-hypothalamic-pituitary-gonadal-axis
#2
JOURNAL ARTICLE
Hira Sayed, Qiongqiong Zhang, Yu Tang, Yanan Wang, Yongpeng Guo, Jianyun Zhang, Cheng Ji, Qiugang Ma, Lihong Zhao
Zearalenone (ZEN) is a non-steroidal estrogenic mycotoxin found in many agricultural products and can cause reproductive disorders, mainly affecting spermatogenesis in male animals. Rutin (RUT) is a natural flavonoid compound recognized for its significant antioxidant, anti-inflammatory and estrogenic properties. The present study aimed to determine the protective role of RUT against ZEN-induced reproductive toxicity in male mice. Twenty-four adult Kunming male mice were divided into four groups: control, RUT (500 mg/kg RUT), ZEN (10 mg/kg ZEN), ZEN + RUT (500 mg/kg RUT + 10 mg/kg ZEN), with six replicates per treatment...
February 29, 2024: Toxins
https://read.qxmd.com/read/38534726/protective-effect-of-vitamin-k2-mk-7-on-acute-lung-injury-induced-by-lipopolysaccharide-in-mice
#3
JOURNAL ARTICLE
Weidong Yang, Yulian Wang, Lulu Liu, Lihong Liu, Shuzhuang Li, Yuyuan Li
Vitamin K2 (MK-7) has been shown to cause significant changes in different physiological processes and diseases, but its role in acute lung injury (ALI) is unclear. Therefore, in this study, we aimed to evaluate the protective effects of VK2 against LPS-induced ALI in mice. The male C57BL/6J mice were randomly divided into six groups (n = 7): the control group, LPS group, negative control group (LPS + Oil), positive control group (LPS + DEX), LPS + VK2 (L) group (VK2, 1.5 mg/kg), and LPS + VK2 (H) group (VK2, 15 mg/kg)...
February 22, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534416/atf4-signaling-in-hiv-1-infection-viral-subversion-of-a-stress-response-transcription-factor
#4
REVIEW
Adrien Corne, Florine Adolphe, Jérôme Estaquier, Sébastien Gaumer, Jean-Marc Corsi
Cellular integrated stress response (ISR), the mitochondrial unfolded protein response (UPRmt), and IFN signaling are associated with viral infections. Activating transcription factor 4 (ATF4) plays a pivotal role in these pathways and controls the expression of many genes involved in redox processes, amino acid metabolism, protein misfolding, autophagy, and apoptosis. The precise role of ATF4 during viral infection is unclear and depends on cell hosts, viral agents, and models. Furthermore, ATF4 signaling can be hijacked by pathogens to favor viral infection and replication...
February 26, 2024: Biology
https://read.qxmd.com/read/38534347/vitamin-d-in-cutaneous-t-cell-lymphoma
#5
REVIEW
August-Witte Feentved Ødum, Carsten Geisler
Cutaneous T-cell lymphoma (CTCL) is characterized by the proliferation of malignant T cells in inflamed skin lesions. Mycosis fungoides (MF)-the most common variant of CTCL-often presents with skin lesions around the abdomen and buttocks ("bathing suit" distribution), i.e., in skin areas devoid of sun-induced vitamin D. For decades, sunlight and vitamin D have been connected to CTCL. Thus, vitamin D induces apoptosis and inhibits the expression of cytokines in malignant T cells. Furthermore, CTCL patients often display vitamin D deficiency, whereas phototherapy induces vitamin D and has beneficial effects in CTCL, suggesting that light and vitamin D have beneficial/protective effects in CTCL...
March 13, 2024: Cells
https://read.qxmd.com/read/38534337/phosphorylations-and-acetylations-of-cytochrome-c-control-mitochondrial-respiration-mitochondrial-membrane-potential-energy-ros-and-apoptosis
#6
REVIEW
Paul T Morse, Tasnim Arroum, Junmei Wan, Lucynda Pham, Asmita Vaishnav, Jamie Bell, Lauren Pavelich, Moh H Malek, Thomas H Sanderson, Brian F P Edwards, Maik Hüttemann
Cytochrome c (Cyt c ) has both life-sustaining and cellular death-related functions, depending on subcellular localization. Within mitochondria, Cyt c acts as a single electron carrier as part of the electron transport chain (ETC). When released into the cytosol after cellular insult, Cyt c triggers the assembly of the apoptosome, committing the cell to intrinsic apoptosis. Due to these dual natures, Cyt c requires strong regulation by the cell, including post-translational modifications, such as phosphorylation and acetylation...
March 12, 2024: Cells
https://read.qxmd.com/read/38533389/myeloid%C3%A2-derived-suppressor-cell-accumulation-induces-treg-expansion-and-modulates-lung-malignancy-progression
#7
JOURNAL ARTICLE
Yinghua Wan, Xiangdong Mu, Jingquan Zhao, Li Li, Wenshuai Xu, Mingqiang Zhang
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous family of myeloid cells that suppress T cell immunity in tumor-bearing hosts. The present study aimed to examine roles of T and MDSC subsets in lung malignancy. The study analyzed 102 cases with lung malignancy and 34 healthy individuals. Flow cytometry was performed for identification of T cell and MDSC subsets and their phenotypic characteristics in peripheral blood. The lung malignancy cases exhibited lower frequencies of granulocyte-like MDSCs (G-MDSCs) expressing PD-L2 and PD-L1 than healthy controls (P=0...
April 2024: Biomedical Reports
https://read.qxmd.com/read/38533033/elucidating-the-anti-cancer-potential-of-cinnamomum-tamala-essential-oil-against-non-small-cell-lung-cancer-a-multifaceted-approach-involving-gc-ms-profiling-network-pharmacology-and-molecular-dynamics-simulations
#8
JOURNAL ARTICLE
Debajani Mohanty, Sucheesmita Padhee, Arpita Priyadarshini, Bibhuti Bhusan Champati, Prabhat Kumar Das, Sudipta Jena, Ambika Sahoo, Pratap Chandra Panda, Sanghamitra Nayak, Asit Ray
Cinnamomum tamala (Buch.-Ham.) T.Nees & Eberm., or Indian Bay Leaf, is a well-known traditional ayurvedic medicine used to treat various ailments. However, the molecular mechanism of action of Cinnamomum tamala essential oil (CTEO) against non-small cell lung cancer (NSCLC) remains elusive. The present study aims to decipher the molecular targets and mechanism of CTEO in treating NSCLC. GC-MS analysis detected 49 constituents; 44 successfully passed the drug-likeness screening and were identified as active compounds...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38532423/association-of-trail-receptor-with-phosphatase-shp-1-enables-repressing-t-cell-receptor-signaling-and-t-cell-activation-through-inactivating-lck
#9
JOURNAL ARTICLE
I-Tsu Chyuan, Hsiu-Jung Liao, Tse-Hua Tan, Huai-Chia Chuang, Yu-Chuan Chu, Meng-Hsun Pan, Chien-Sheng Wu, Ching-Liang Chu, Bor-Ching Sheu, Ping-Ning Hsu
BACKGROUND: T cell receptor (TCR) signaling and T cell activation are tightly regulated by gatekeepers to maintain immune tolerance and avoid autoimmunity. The TRAIL receptor (TRAIL-R) is a TNF-family death receptor that transduces apoptotic signals to induce cell death. Recent studies have indicated that TRAIL-R regulates T cell-mediated immune responses by directly inhibiting T cell activation without inducing apoptosis; however, the distinct signaling pathway that regulates T cell activation remains unclear...
March 27, 2024: Journal of Biomedical Science
https://read.qxmd.com/read/38531922/retraction-note-norcantharidin-combined-with-coix-seed-oil-synergistically-induces-apoptosis-and-inhibits-hepatocellular-carcinoma-growth-by-downregulating-regulatory-t-cells-accumulation
#10
Dan Wang, Chendong Yang, Zhuien Wang, Yi Yang, Defang Li, Xiaojie Ding, Wenjuan Xu, Qiusheng Zheng
No abstract text is available yet for this article.
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38531803/analysis-and-investigation-of-bioinformatics-and-epigenetics-reveal-the-underlying-mechanisms-by-which-flot2-modulates-the-progression-of-diffuse-large-b-cell-lymphoma
#11
JOURNAL ARTICLE
Yujing Zhang, Yao Chen, Qiang Guo, Ying Zhang, Aichun Liu
BACKGROUND: Diffuse large B-cell lymphoma (DLBCL) poses a significant threat to the quality of life for people worldwide. Regrettably, effective treatment strategies for this disease remain elusive in clinical practice due to the unclear understanding of its molecular mechanisms. Therefore, this study was devised to address these issues and identify novel diagnostic, therapeutic, and prognostic biomarkers for DLBCL. METHODS: Gene expression and clinical data for DLBCL patients were retrieved from The Cancer Genome Atlas (TCGA) database, and relevant clinical data, tumor mutational burden (TMB), and gene expression levels were extracted...
March 2024: Discovery Medicine
https://read.qxmd.com/read/38528641/low-expression-of-mir-182-caused-by-dna-hypermethylation-accelerates-acute-lymphocyte-leukemia-development-by-targeting-pbx3-and-bcl2-mir-182-promoter-methylation-is-a-predictive-marker-for-hypomethylation-agents%C3%A2-%C3%A2-bcl2-inhibitor-venetoclax
#12
JOURNAL ARTICLE
Danyang Li, Yigang Yuan, Chen Meng, Zihan Lin, Min Zhao, Liuzhi Shi, Min Li, Daijiao Ye, Yue Cai, Xiaofei He, Haige Ye, Shujuan Zhou, Haixia Zhou, Shenmeng Gao
BACKGROUND: miR-182 promoter hypermethylation frequently occurs in various tumors, including acute myeloid leukemia, and leads to low expression of miR-182. However, whether adult acute lymphocyte leukemia (ALL) cells have high miR-182 promoter methylation has not been determined. METHODS: To assess the methylation status of the miR-182 promoter, methylation and unmethylation-specific PCR analysis, bisulfite-sequencing analysis, and MethylTarget™ assays were performed to measure the frequency of methylation at the miR-182 promoter...
March 26, 2024: Clinical Epigenetics
https://read.qxmd.com/read/38526708/role-of-c-ebp-homologous-protein-in-vascular-stenosis-after-carotid-artery-injury
#13
JOURNAL ARTICLE
Lin Teng, Qin Qin, Zi-Yi Zhou, Fei Zhou, Cun-Yu Cao, Chao He, Jia-Wang Ding, Jian Yang
The study aims to explore the fluctuating expression of C/EBP Homologous Protein (CHOP) following rat carotid artery injury and its central role in vascular stenosis. Using in vivo rat carotid artery injury models and in vitro ischemia and hypoxia cell models employing human aortic endothelial cells (HAECs) and vascular smooth muscle cells (T/G HA-VSMCs), a comprehensive investigative framework was established. Histological analysis confirmed intimal hyperplasia in rat models. CHOP expression in vascular tissues was assessed using Western blot and immunohistochemical staining, and its presence in HAECs and T/G HA-VSMCs was determined through RT-PCR and Western blot...
March 25, 2024: Biochemical Genetics
https://read.qxmd.com/read/38526307/brain-delivery-of-biomimetic-phosphorus-dendrimer-antibody-nanocomplexes-for-enhanced-glioma-immunotherapy-via-immune-modulation-of-t-cells-and-natural-killer-cells
#14
JOURNAL ARTICLE
Yamin Peng, Mengsi Zhan, Andrii Karpus, Yu Zou, Serge Mignani, Jean-Pierre Majoral, Xiangyang Shi, Mingwu Shen
Fully mobilizing the activities of multiple immune cells is crucial to achieve the desired tumor immunotherapeutic efficacy yet still remains challenging. Herein, we report a nanomedicine formulation based on phosphorus dendrimer (termed AK128)/programmed cell death protein 1 antibody (aPD1) nanocomplexes (NCs) that are camouflaged with M1-type macrophage cell membranes (M1m) for enhanced immunotherapy of orthotopic glioma. The constructed AK128-aPD1@M1m NCs with a mean particle size of 160.3 nm possess good stability and cytocompatibility...
March 25, 2024: ACS Nano
https://read.qxmd.com/read/38526284/cav3-2-channel-regulates-cerebral-ischemia-reperfusion-injury-a-promising-target-for-intervention
#15
JOURNAL ARTICLE
Feibiao Dai, Chengyun Hu, Xue Li, Zhetao Zhang, Hongtao Wang, Wanjun Zhou, Jiawu Wang, Qingtian Geng, Yongfei Dong, Chaoliang Tang
JOURNAL/nrgr/04.03/01300535-202419110-00028/figure1/v/2024-03-08T184507Z/r/image-tiff Calcium influx into neurons triggers neuronal death during cerebral ischemia/reperfusion injury. Various calcium channels are involved in cerebral ischemia/reperfusion injury. Cav3.2 channel is a main subtype of T-type calcium channels. T-type calcium channel blockers, such as pimozide and mibefradil, have been shown to prevent cerebral ischemia/reperfusion injury-induced brain injury. However, the role of Cav3.2 channels in cerebral ischemia/reperfusion injury remains unclear...
November 1, 2024: Neural Regeneration Research
https://read.qxmd.com/read/38526029/depletion-of-cpne7-sensitizes-colorectal-cancer-to-5-fluorouracil-by-downregulating-atg9b-expression
#16
JOURNAL ARTICLE
Weile Xu, Yujie Tang, Yang Yang, Changjing Wang, Chen Liu, Jianqing Zhang, Lianmei Zhao, Guiying Wang
We aimed to explore the biological function of CPNE7 and determine the impact of CPNE7 on chemotherapy resistance in colorectal cancer (CRC) patients. According to the Gene Expression Profiling Interactive Analysis database and previously published data, CPNE7 was identified as a potential oncogene in CRC. RT-qPCR and Western blotting were performed to verify the expression of CPNE7. Chi-square test was used to evaluate the associations between CPNE7 and clinical features. Cell proliferation, colony formation, cell migration and invasion, cell cycle and apoptosis were assessed to determine the effects of CPNE7...
April 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38525441/the-role-of-tim3-nk-and-tim3-nk-cells-in-the-immune-pathogenesis-of-severe-aplastic-anemia
#17
JOURNAL ARTICLE
Shaoxue Ding, Tian Zhang, Yingying Lei, Chunyan Liu, Zhaoyun Liu, Rong Fu
BACKGROUND: Natural killer (NK) cells play important immunoregulatory roles in the immune pathogenesis of severe aplastic anemia (SAA). Our previous research showed that SAA caused a decrease in T cell immunoglobulin mucin-3 (TIM3) expression on NK cells. Here we investigated the expression of surface receptors, and the cytotoxicity of peripheral TIM3+ NK and TIM3- NK cells in patients with SAA. METHODS: The expressions of surface receptors and cytoplasmic protein of TIM3+ NK and TIM3- NK cells from peripheral blood were detected by FCM...
February 2024: Journal of Translational Internal Medicine
https://read.qxmd.com/read/38525131/n-acetylcysteine-protects-against-diazinon-induced-histopathological-damage-and-apoptosis-in-renal-tissue-of-rats
#18
JOURNAL ARTICLE
Gaiqin Dong, Qingfeng Li, Chun Yu, Qing Wang, Danhua Zuo, Xiaozhong Li
Diazinon (DZN) is a member of organophosphorus insecticides that has cytotoxic effects on different organs. n-Acetyl cysteine (NAC) is a widely used antioxidant in clinical, in vivo and in vitro studies. We evaluated the protective role of NAC against DZN-induced toxicity in kidney tissue of Wistar rats. 30 male Wistar rats were divided into 5 groups of control, single dose of DZN, continuous dose of DZN, single doses of DZN + NAC and continuous doses of DZN + NAC. Kidney function test (blood urea nitrogen, creatinine and uric acid) was provided...
April 2024: Toxicological Research
https://read.qxmd.com/read/38524667/laminin-511-e8-an-autoantigen-in-igg4-related-cholangitis-contributes-to-cholangiocyte-protection
#19
JOURNAL ARTICLE
David C Trampert, Remco Kersten, Dagmar Tolenaars, Aldo Jongejan, Stan F J van de Graaf, Ulrich Beuers
BACKGROUND & AIMS: IgG4-related cholangitis (IRC) is the hepatobiliary manifestation of IgG4-related disease. Anti-laminin 511-E8 autoantibodies have been identified in its pancreatic manifestation. Laminin 511-E8 promotes endothelial barrier function, lymphocyte recruitment, and cholangiocyte differentiation. Here, we investigate anti-laminin 511-E8 autoantibody presence in IRC, and mechanisms via which laminin 511 may contribute to cholangiocyte protection. METHODS: Anti-laminin 511-E8 serum autoantibody positivity was assessed by ELISA...
April 2024: JHEP reports: innovation in hepatology
https://read.qxmd.com/read/38522817/extracellular-vesicles-derived-from-dendritic-cells-loaded-with-vegf-a-sirna-and-doxorubicin-reduce-glioma-angiogenesis-in-vitro
#20
JOURNAL ARTICLE
Parisa Shamshiripour, Mehrana Rahnama, Mehdi Nikoobakht, Vahideh Farzam Rad, Ali-Reza Moradi, Davoud Ahmadvand
BACKGROUND: Numerous attempts have been devoted to designing anti-angiogenic agents as a strategy to slow tumor growth and progression. Clinical applications of conventional anti-angiogenic agents face some challenges, e.g., off-target effects for TKIs and also low solid tumor penetration for mAbs. Furthermore, although anti-angiogenic therapy provides a normalization window for better chemo-RT response, in long-term treatments, tumor hypoxia as a result of total removal of VEGF-A by mAbs from the TME or complete blockade of TK receptors induces over-activation of compensatory angiogenic pathways, causing escape...
March 22, 2024: Journal of Controlled Release
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