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Fat fraction mri

Arash Latifoltojar, Margaret Hall-Craggs, Neil Rabin, Rakesh Popat, Alan Bainbridge, Nikolaos Dikaios, Magdalena Sokolska, Ali Rismani, Shirley D'Sa, Shonit Punwani, Kwee Yong
Cross-sectional imaging techniques are being increasingly used for disease evaluation in patients with multiple myeloma. Whole body magnetic resonance imaging (WB-MRI) scanning is superior to plain radiography in baseline assessment of patients but changes following treatment have not been systematically explored. We carried out paired WB-MRI scans in 21 newly diagnosed patients prior to, and 8-weeks after, starting chemotherapy, and analysed stringently selected focal lesions (FLs) for parametric changes. A total of 323 FLs were evaluated, median 20 per patient...
October 21, 2016: British Journal of Haematology
Guanwu Li, Zheng Xu, Lingmi Hou, Xuefeng Li, Xin Li, Wei Yuan, Maki Polat, Shixin Chang
Bisphenol A diglycidyl ether (BADGE), a PPARγ2 antagonist, has been shown to inhibit marrow adipogenesis and promotes bone formation in intact animals. We investigated the impact of BADGE on a new and more clinically relevant physiological model, the ovariectomized (OVX) rat model. Forty female Wistar rats were divided into four treatment groups (n=10/group): sham+vehicle, sham+BADGE, OVX+vehicle and OVX+BADGE for 12 weeks. Postmortem analyses included MRI, micro-CT, serological test, histomorphometry, biomechanical tests, RT-PCR and western blot...
October 18, 2016: American Journal of Physiology. Endocrinology and Metabolism
Julia R Dahlqvist, Christoffer R Vissing, Gitte Hedermann, Carsten Thomsen, John Vissing
PURPOSE: The aim of this study was to investigate the age-related changes in fatty replacement and cross sectional area (CSA) of cervical, thoracic and lumbar paraspinal muscles vs. leg muscles in healthy adults, and to test for association between muscle fat fraction and lifestyle factors. METHODS: Fifty-three healthy adults (24-76 years) were included. Dixon MRI technique was used to determine CSA and quantify fat fraction of paraspinal and leg muscles. Muscle CSA and fat fractions were tested for association with age and muscle strength...
October 13, 2016: Medicine and Science in Sports and Exercise
Harald Kramer, Perry J Pickhardt, Mark A Kliewer, Diego Hernando, Guang-Hong Chen, James A Zagzebski, Scott B Reeder
OBJECTIVE: The purpose of this study was to prospectively evaluate the accuracy of proton-density fat-fraction, single- and dual-energy CT (SECT and DECT), gray-scale ultrasound (US), and US shear-wave elastography (US-SWE) in the quantification of hepatic steatosis with MR spectroscopy (MRS) as the reference standard. SUBJECTS AND METHODS: Fifty adults who did not have symptoms (23 men, 27 women; mean age, 57 ± 5 years; body mass index, 27 ± 5) underwent liver imaging with un-enhanced SECT, DECT, gray-scale US, US-SWE, proton-density fat-fraction MRI, and MRS for this prospective trial...
October 11, 2016: AJR. American Journal of Roentgenology
Hye Jin Yoo, Sung Hwan Hong, Dong Hyun Kim, Ja-Young Choi, Hee Dong Chae, Bo Mi Jeong, Joong Mo Ahn, Heung Sik Kang
PURPOSE: To determine whether fat-signal-fraction (FF) map using a modified Dixon sequence could help differentiate benign from malignant bone lesions. MATERIALS AND METHODS: Spine magnetic resonance images (MRIs) of 120 consecutive patients were studied by using a 3T MRI with standard T1 -weighted image (T1 WI) and modified-Dixon sequence for FF measurement. There were three groups: a control group (n = 51) with normal vertebrae; a benign group (n = 40) with focal red marrow deposition, Schmorl's nodes, benign compression fracture, or Modic type 1 endplate degeneration; a malignant group (n = 29) with spinal malignancies...
September 30, 2016: Journal of Magnetic Resonance Imaging: JMRI
Paul M Manning, Gavin Hamilton, Kang Wang, Chulhyun Park, Jonathan C Hooker, Tanya Wolfson, Anthony Gamst, William M Haufe, Alex N Schlein, Michael S Middleton, Claude B Sirlin
PURPOSE: To compare agreement between region-of-interest (ROI)- and parametric map-based methods of hepatic proton density fat fraction (PDFF) estimation in adults with known or suspected hepatic steatosis secondary to chronic liver disease over a range of imaging and analysis conditions. MATERIALS AND METHODS: In this IRB approved HIPAA compliant prospective single-site study, 31 adults with chronic liver disease undergoing clinical gadoxetic acid-enhanced liver magnetic resonance imaging at 3 T were recruited...
September 29, 2016: Abdominal Radiology
Yu-Chun Lo, Yu-Jen Chen, Yung-Chin Hsu, Wen-Yih Isaac Tseng, Susan Shur-Fen Gau
BACKGROUND: Autism spectrum disorder (ASD) is a neurodevelopmental disorder with social communication deficits as one of the core symptoms. Recently, a five-level model for the social communication has been proposed in which white matter tracts corresponding to each level of the model are identified. Given that the model for social communication subserves social language functions, we hypothesized that the tract integrity of the model for social communication may be reduced in ASD, and the reduction may be related to social communication deficits...
September 28, 2016: Journal of Child Psychology and Psychiatry, and Allied Disciplines
Temel Tirkes, Evan L Fogel, Stuart Sherman, Chen Lin, Jordan Swensson, Fatih Akisik, Kumaresan Sandrasegaran
PURPOSE: To determine if T1-weighted MR signal of the pancreas can be used to detect early CP. METHODS: A retrospective analysis was performed on 51 suspected CP patients, who had both secretin-enhanced magnetic resonance cholangiopancreatography (S-MRCP) and an intraductal secretin stimulation test (IDST). There were 29 patients in normal and 22 patients in the low bicarbonate group. Bicarbonate level, total pancreatic juice volume, and excretory flow rate were recorded during IDST...
September 23, 2016: Abdominal Radiology
Timothy J Colgan, Diego Hernando, Samir D Sharma, Scott B Reeder
PURPOSE: The purpose of this work was to characterize the effects of concomitant gradients (CGs) on chemical shift encoded (CSE)-based estimation of B0 field map, proton density fat fraction (PDFF), and R2*. THEORY: A theoretical framework was used to determine the effects of CG-induced phase errors on CSE-MRI data. METHODS: Simulations, phantom experiments, and in vivo experiments were conducted at 3 Tesla to assess the effects of CGs on quantitative CSE-MRI techniques...
September 21, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
Valeria Ricotti, Matthew R B Evans, Christopher D J Sinclair, Jordan W Butler, Deborah A Ridout, Jean-Yves Hogrel, Ahmed Emira, Jasper M Morrow, Mary M Reilly, Michael G Hanna, Robert L Janiczek, Paul M Matthews, Tarek A Yousry, Francesco Muntoni, John S Thornton
OBJECTIVE: A number of promising experimental therapies for Duchenne muscular dystrophy (DMD) are emerging. Clinical trials currently rely on invasive biopsies or motivation-dependent functional tests to assess outcome. Quantitative muscle magnetic resonance imaging (MRI) could offer a valuable alternative and permit inclusion of non-ambulant DMD subjects. The aims of our study were to explore the responsiveness of upper-limb MRI muscle-fat measurement as a non-invasive objective endpoint for clinical trials in non-ambulant DMD, and to investigate the relationship of these MRI measures to those of muscle force and function...
2016: PloS One
Guanwu Li, Zheng Xu, Jingzheng Fan, Wei Yuan, Lina Zhang, Lingmi Hou, Dongmei Wu, Shixin Chang, Horea Calimente, Jiani Hu
OBJECTIVE: To assess the differential features of marrow adiposity between osteoarthritis (OA) and osteoporosis (OP) in postmenopausal women using water/fat MRI. METHODS: This cross-sectional study included 97 postmenopausal women (OA [n = 25], OA + osteopenia [n = 27], OA + OP [n = 23], and OP groups [n = 22]). Water/fat MRI, dual-energy x-ray absorptiometry and biochemical analysis were performed to assess vertebral marrow fat fraction, bone mineral density, and bone biomarkers, respectively...
September 19, 2016: Menopause: the Journal of the North American Menopause Society
Lena K L Oestreich, Ofer Pasternak, Martha E Shenton, Marek Kubicki, Xue Gong, Simon McCarthy-Jones, Thomas J Whitford
BACKGROUND: There is growing evidence to suggest that delusions associated with schizophrenia arise from altered structural brain connectivity. The present study investigated whether structural changes in three major fasciculi that interconnect the limbic system - the cingulum bundle, uncinate fasciculus and fornix - are associated with delusions in chronic schizophrenia patients. METHODS: Free-water corrected Diffusion Tensor Imaging was used to investigate the association between delusions and both microstructural changes within these three fasciculi and extracellular changes in the surrounding free-water...
2016: NeuroImage: Clinical
Yipeng Cheng, Kewei Zhang, Yang Chen, Yanchuan Li, Yuzheng Li, Kuang Fu, Rennan Feng
Dietary habits are crucial in the progression of hepatic lipid accumulation and nonalcoholic fatty liver disease (NAFLD). However, there are limited studies using ¹H-magnetic resonance spectroscopy (¹H-MRS) and dual-echo in-phase and out-phase magnetic resonance spectroscopy imaging (dual-echo MRI) to assess the effects of dietary nutrient intakes on hepatic lipid contents. In the present study, we recruited 36 female adults (NAFLD:control = 19:17) to receive questionnaires and medical examinations, including dietary intakes, anthropometric and biochemical measurements, and ¹H-MRS and dual-echo MRI examinations...
2016: Nutrients
Dian Liu, Helen L Parker, Jelena Curcic, Sebastian Kozerke, Andreas Steingoetter
BACKGROUND: Oil-in-water emulsions have recently become of interest to nutritional sciences because of their ability to influence gastrointestinal digestive processes and ultimately benefit human health. MRI offers the potential to noninvasively characterize the interaction between emulsified lipids and gastric secretion within the stomach. OBJECTIVES: We determined noninvasively how emulsion stability modulates volumes of fat and secretion, layering of fat, and the mixing of emulsified fat with secretion within the stomach...
October 2016: Journal of Nutrition
Stephen Bawden, Mary Stephenson, Yirga Falcone, Melanie Lingaya, Elisabetta Ciampi, Karl Hunter, Frances Bligh, Jorg Schirra, Moira Taylor, Peter Morris, Ian Macdonald, Penny Gowland, Luca Marciani, Guruprasad Aithal
AIMS: To investigate the acute and longer term effects of low (LGI) v high (HGI) glycaemic index diets on hepatic fat and glycogen accumulation and related blood measures in healthy volunteers. METHODS: Eight healthy males (age = 20.1 ± 0.4y, BMI=23.0 ± 0.9 kg/m2) attended a test day before and after a 7-day macronutrient and energy matched HGI or LGI diet, followed by a minimum 4 week wash-out period, and then returning to repeat the intervention with the alternative diet...
September 4, 2016: Diabetes, Obesity & Metabolism
Janki Patel, Ricki Bettencourt, Jeffrey Cui, Joanie Salotti, Jonathan Hooker, Archana Bhatt, Carolyn Hernandez, Phirum Nguyen, Hamed Aryafar, Mark Valasek, William Haufe, Catherine Hooker, Lisa Richards, Claude B Sirlin, Rohit Loomba
BACKGROUND: Magnetic resonance imaging-estimated proton-density-fat-fraction (MRI-PDFF) has been shown to be a noninvasive, accurate and reproducible imaging-based biomarker for assessing steatosis and treatment response in nonalcoholic steatohepatitis (NASH) clinical trials. However, there are no data on the magnitude of MRI-PDFF reduction corresponding to histologic response in the setting of a NASH clinical trial. The aim of this study was to quantitatively compare the magnitude of MRI-PDFF reduction between histologic responders versus histologic nonresponders in NASH patients...
September 2016: Therapeutic Advances in Gastroenterology
Weiguo Li, Xifu Wang, Frank H Miller, Andrew C Larson
PURPOSE: The purpose of this work was to develop a chemical shift magnetization transfer (CSMT) magnetic resonance imaging (MRI) method to provide accurate magnetization transfer ratio (MTR) measurements in the presence of fat. METHODS: Numerical simulations were performed to compare MTR measurements at different echo times (TEs) for voxels with varying fat/water content. The CSMT approach was developed using water fraction estimates to correct for the impact of fat signal upon observed MTR measurements...
August 31, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
Jessica Schreiber-Zinaman, Andrew B Rosenkrantz
PURPOSE: The purpose of the study was to identify the frequency and reasons for extra sequences in clinical liver MRI and MRCP examinations. METHODS: A total of 250 consecutive liver MRI and 250 consecutive MRCP examinations performed at a single institution were reviewed. Extra sequences performed in comparison with our standard institutional protocol were identified. Reasons for the extra sequences were identified. Overall trends were assessed. RESULTS: In significantly greater fractions of exams (p = 0...
August 23, 2016: Abdominal Radiology
Novena A Rangwala, Isabel Dregely, Holden H Wu, Kyunghyun Sung
PURPOSE: To optimize and evaluate the reference region variable flip angle (RR-VFA) technique for simultaneous B1+ and T1 mapping of the prostate at 3 Tesla (T). MATERIALS AND METHODS: The fat region surrounding the prostate was first identified using a fractional fat segmentation constant (tF ) and a signal fat-fraction threshold (rF ), and the relative flip angle (FA) was characterized using an effective fat T1 (T1f ) within the fat region. Optimal values of tF , rF , and T1f were chosen by comparing relative FA maps using RR-VFA (ARR-VFA ) with a reference relative FA maps (AREF ) in the surrounding fat and evaluating interpolation errors within the prostate...
August 17, 2016: Journal of Magnetic Resonance Imaging: JMRI
Bahar Shahidi, Callan L Parra, David B Berry, James C Hubbard, Sara Gombatto, Vinko Zlomislic, R Todd Allen, Jan Hughes-Austin, Steven Garfin, Samuel R Ward
STUDY DESIGN: Retrospective chart analysis of 199 individuals aged 18-80 years scheduled for lumbar spine surgery. OBJECTIVE: The purpose of this study was to quantify changes in muscle cross sectional area (CSA) and fat signal fraction (FSF) with age in men and women with lumbar spine pathology and compare them to published normative data. SUMMARY OF BACKGROUND DATA: Pathological changes in lumbar paraspinal muscle are often confounded by age-related decline in muscle size (CSA) and quality (fatty infiltration)...
August 11, 2016: Spine
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