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Fat fraction mri

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https://www.readbyqxmd.com/read/29148120/mapping-brown-adipose-tissue-based-on-fat-water-fraction-provided-by-z-spectral-imaging
#1
Alessandro Scotti, Rong-Wen Tain, Weiguo Li, Victoria Gil, Chong Wee Liew, Kejia Cai
BACKGROUND: Brown adipose tissue (BAT) has a great relevance in metabolic diseases and has been shown to be reduced in obesity and insulin resistance patients. Currently, Dixon MRI is used to calculate fat-water fraction (FWF) and differentiate BAT from white adipose tissue (WAT). However, it may fail in areas of phase wrapping and introduce fat-water swapping artifacts. PURPOSE: To investigate the capacity of the Z-spectrum imaging (ZSI) for the identification of BAT in vivo...
November 17, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29130901/quantification-of-fat-fraction-in-lumbar-vertebrae-correlation-with-age-and-implications-for-bone-marrow-dosimetry-in-molecular-radiotherapy
#2
Maikol Salas-Ramirez, Johannes Tran-Gia, Christian Kesenheimer, Andreas Max Weng, Aleksander Kosmala, Anke Heidemeier, Herbert Koestler, Michael Lassmann
Absorbed dose to active bone marrow is a predictor of hematological toxicity in molecular radiotherapy. Due to the complex composition of bone marrow tissue, the necessity to improve the personalized dosimetry has led to the application of non-conventional imaging methods in nuclear medicine. The aim of this study is to apply magnetic resonance imaging (MRI) for quantification of the fat fraction in lumbar vertebrae and to analyze its implications for bone marrow dosimetry. Methods First, a highly accelerated two-point Dixon MRI sequence for fat-water separation was validated in a 3T system against the magnetic resonance spectroscopy (MRS) gold standard...
November 13, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29130550/-1-h-nmrs-of-carnosine-combined-with-31-p-nmrs-to-better-characterize-skeletal-muscle-ph-dysregulation-in-duchenne-muscular-dystrophy
#3
Harmen Reyngoudt, Suna Turk, Pierre G Carlier
In recent years, quantitative nuclear magnetic resonance imaging and spectroscopy (NMRI and NMRS) have been used more systematically as outcome measures in natural history and clinical trial studies for Duchenne muscular dystrophy (DMD). Whereas most of these studies have emphasized the evaluation of the fat fraction as an assessment for disease severity, less focus has been placed on metabolic indices measured by NMRS. (31) P NMRS in DMD reveals an alkaline inorganic phosphate (Pi ) pool, originating from either leaky dystrophic myocytes or an increased interstitial space...
November 12, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/29130539/sources-of-systematic-error-in-proton-density-fat-fraction-pdff-quantification-in-the-liver-evaluated-from-magnitude-images-with-different-numbers-of-echoes
#4
Mark Bydder, Gavin Hamilton, Ludovic de Rochefort, Ajinkya Desai, Elhamy R Heba, Rohit Loomba, Jeffrey B Schwimmer, Nikolaus M Szeverenyi, Claude B Sirlin
The purpose of this work was to investigate sources of bias in magnetic resonance imaging (MRI) liver fat quantification that lead to a dependence of the proton density fat fraction (PDFF) on the number of echoes. This was a retrospective analysis of liver MRI data from 463 subjects. The magnitude signal variation with TE from spoiled gradient echo images was curve fitted to estimate the PDFF using a model that included monoexponential R2 * decay and a multi-peak fat spectrum. Additional corrections for non-exponential decay (Gaussian), bi-exponential decay, degree of fat saturation, water frequency shift and noise bias were introduced...
November 12, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/29108123/optimal-threshold-of-controlled-attenuation-parameter-with-mri-pdff-as-the-gold-standard-for-the-detection-of-hepatic-steatosis
#5
Cyrielle Caussy, Mosab H Alquiraish, Phirum Nguyen, Carolyn Hernandez, Sandra Cepin, Lynda E Fortney, Veeral Ajmera, Ricki Bettencourt, Summer Collier, Jonathan Hooker, Ethan Sy, Emily Rizo, Lisa Richards, Claude B Sirlin, Rohit Loomba
The optimal threshold of controlled attenuation parameter (CAP) for the detection of hepatic steatosis using both M and XL probe is unknown in nonalcoholic fatty liver disease (NAFLD). Magnetic resonance imaging proton-density-fat-fraction (MRI-PDFF) is an accurate and precise method to detect presence of hepatic steatosis and is better than CAP. Thus, the aim of this study was to evaluate the diagnostic accuracy and the optimal threshold of CAP for the detection of hepatic steatosis as defined by MRI-PDFF ≥ 5%...
November 6, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29102430/involvement-of-pelvic-girdle-and-proximal-leg-muscles-in-early-oculopharyngeal-muscular-dystrophy
#6
B M van der Sluijs, S Lassche, G J Knuiman, B Kusters, A Heerschap, M Hopman, T H Schreuder, B G M van Engelen, N C Voermans
Although limb girdle weakness is not part of the major diagnostic criteria of oculopharyngeal muscular dystrophy (OPMD), it has frequently been observed in the Dutch and other OPMD cohorts. In the Dutch cohort, this might be related to the relatively old age or the severity of the genetic defect. This patient-control study (14 OPMD patients and 12 controls) investigated the involvement of limb girdle muscles with a multidimensional approach in early OPMD. We assessed functional abilities, disease impact, physical activity, muscle strength, histopathology and fatty infiltration using questionnaires, actometer, functional tests, manual and quantitative muscle testing, muscle biopsy and muscle MRI...
September 28, 2017: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/29089822/impact-of-liver-fibrosis-and-fatty-liver-on-t1rho-measurements-a-prospective-study
#7
Shuangshuang Xie, Qing Li, Yue Cheng, Yu Zhang, Zhizheng Zhuo, Guiming Zhao, Wen Shen
OBJECTIVE: To investigate the liver T1rho values for detecting fibrosis, and the potential impact of fatty liver on T1rho measurements. MATERIALS AND METHODS: This study included 18 healthy subjects, 18 patients with fatty liver, and 18 patients with liver fibrosis, who underwent T1rho MRI and mDIXON collections. Liver T1rho, proton density fat fraction (PDFF) and T2* values were measured and compared among the three groups. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the T1rho values for detecting liver fibrosis...
November 2017: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/29080242/can-negligible-hepatic-steatosis-determined-by-mri-proton-density-fat-fraction-obviate-the-need-for-liver-biopsy-in-potential-liver-donors
#8
Janakan Satkunasingham, Hooman Hosseini Nik, Sandra Fischer, Ravi Menezes, Nazia Selzner, Mark Cattral, David Grant, Kartik Jhaveri
PURPOSE: To determine whether magnetic resonance proton density fat fraction (MR-PDFF) estimate of negligible hepatic fat percentage (<5%) can exclude significant hepatic steatosis (≥ 10%) in living liver donor candidates obviating the need for liver biopsy. To perform intra-individual comparisons between MR-PDFF techniques for hepatic steatosis quantification. MATERIALS AND METHODS: In an ethics approved retrospective study, 144 liver donor candidates with MR spectroscopy (MRS) and six-echo Dixon MRI between 2013 and 2015 were included...
October 28, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/29063256/sciatic-neurosteatosis-relationship-with-age-gender-obesity-and-height
#9
Shayna Ratner, Raamis Khwaja, Lihua Zhang, Yin Xi, Riham Dessouky, Craig Rubin, Avneesh Chhabra
AIM: To evaluate inter-reader performance for cross-sectional area and fat quantification of bilateral sciatic nerves on MRI and assess correlations with anthropometrics. METHODS: In this IRB-approved, HIPPA-compliant study, three readers performed a cross-sectional analysis of 3T lumbosacral plexus MRIs over an 18-month period. Image slices were evaluated at two levels (A and B). The sciatic nerve was outlined using a free hand region of interest tool on PACS. Proton-density fat fraction (FF) and cross-sectional areas were recorded...
October 23, 2017: European Radiology
https://www.readbyqxmd.com/read/29050981/evolutional-change-in-epicardial-fat-and-its-correlation-with-myocardial-diffuse-fibrosis-in-heart-failure-patients
#10
Cho-Kai Wu, Hao-Yuan Tsai, Mao-Yuan M Su, Yi-Fan Wu, Juey-Jen Hwang, Jiunn-Lee Lin, Lian-Yu Lin, Jien-Jiun Chen
OBJECTIVES: The aim of this study was to characterize the characteristics of epicardial fat (EAT) in different stage heart failure (HF) patients and its relationship between cardiac fibrosis. BACKGROUND: EAT is visceral adipose tissue that possesses inflammatory properties. Inflammation and obesity are associated with cardiac fibrosis, but the relationship between cardiac fibrosis and EAT is unknown. METHODS: EAT volume was measured using cardiac magnetic resonance imaging (CMR) in 180 subjects: 58 patients with systolic HF, 63 patients with HF and preserved ejection fraction, and 59 patients without HF...
September 4, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29050160/-value-of-mdixon-quant-sequence-diffusion-weighted-imaging-in-quantitatively-diagnosing-the-sacroiliitis-stages
#11
Y Y An, H X Li, Y Zhan, X W Lei
Objective: To evaluate the value of mDIXON-Quant sequence, diffusion-weighted imaging (DWI) in quantitative diagnosing of the sacroiliitis stages in patients with ankylosing spondylitis (AS). Methods: Based on the Bath Ankylosing Spondylitis Activity Index (BASDAI) and laboratory parameters, a total of 51 patients were diagnosed with AS. They were divided into two groups as early active group (n=20) and chronic active group (n=31), and at the same time, 25 healthy people from Tianjin were included as control group...
October 10, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29046229/fetal-overnutrition-and-adolescent-hepatic-fat-fraction-the-exploring-perinatal-outcomes-in-children-study
#12
Anna Bellatorre, Ann Scherzinger, Elizabeth Stamm, Mercedes Martinez, Brandy Ringham, Dana Dabelea
OBJECTIVE: To determine if fetal overnutrition resulting from maternal obesity or gestational diabetes mellitus (GDM) is associated with increased liver fat during adolescence, adjusting for past and current metabolic risk factors. STUDY DESIGN: Data come from a historical prospective cohort study (Exploring Perinatal Outcomes in Children) of 254 mother-child pairs in Colorado who participated in 2 research visits at T1 (mean age 10.4, SD = 1.5 years) and at T2 (mean age 16...
October 15, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29045180/quantitative-liver-mri-biopsy-correlation-in-pediatric-and-young-adult-patients-with-nonalcoholic-fatty-liver-disease-can-one-be-used-to-predict-the-other
#13
Jonathan R Dillman, Andrew T Trout, Emma N Costello, Suraj D Serai, Kristin S Bramlage, Rohit Kohli, Stavra A Xanthakos
OBJECTIVE: The purpose of this study is to determine the relationships between quantitative liver MRI measurements and liver biopsy findings in pediatric and young adult patients with nonalcoholic fatty liver disease (NAFLD). MATERIALS AND METHODS: Data were obtained from a registry that prospectively enrolls pediatric and young adult patients with biopsy-confirmed NAFLD at our tertiary medical center with parent or guardian and subject informed consent, as appropriate...
October 18, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29030457/adding-quantitative-muscle-mri-to-the-fshd-clinical-trial-toolbox
#14
Karlien Mul, Sanne C C Vincenten, Nicol C Voermans, Richard J L F Lemmers, Patrick J van der Vliet, Silvère M van der Maarel, George W Padberg, Corinne G C Horlings, Baziel G M van Engelen
OBJECTIVE: To add quantitative muscle MRI to the clinical trial toolbox for facioscapulohumeral muscular dystrophy (FSHD) by correlating it to clinical outcome measures in a large cohort of genetically and clinically well-characterized patients with FSHD comprising the entire clinical spectrum. METHODS: Quantitative MRI scans of leg muscles of 140 patients with FSHD1 and FSHD2 were assessed for fatty infiltration and TIRM hyperintensities and were correlated to multiple clinical outcome measures...
October 13, 2017: Neurology
https://www.readbyqxmd.com/read/29028128/diagnostic-accuracy-of-magnetic-resonance-imaging-hepatic-proton-density-fat-fraction-in-pediatric-nonalcoholic-fatty-liver-disease
#15
Michael S Middleton, Mark L Van Natta, Elhamy R Heba, Adina Alazraki, Andrew T Trout, Prakash Masand, Elizabeth M Brunt, David E Kleiner, Edward Doo, James Tonascia, Joel E Lavine, Wei Shen, Gavin Hamilton, Jeffrey B Schwimmer, Claude B Sirlin
We assessed the performance of magnetic resonance imaging (MRI) proton density fat fraction (PDFF) in children to stratify hepatic steatosis grade before and after treatment in the Cysteamine Bitartrate Delayed-Release for the Treatment of Nonalcoholic Fatty Liver Disease in Children (CyNCh) trial, using centrally-scored histology as reference. Participants had multi-echo 1.5T or 3T MRI on scanners from three manufacturers. Of 169 enrolled children, 110 (65%) and 83 (49%) had MRI and liver biopsy at baseline and at end-of-treatment (EOT; 52-weeks), respectively...
October 13, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29022777/feasibility-of-modified-dixon-mri-techniques-for-hepatic-fat-quantification-in-hepatic-disorders-validation-with-mrs-and-histology
#16
Bo-Kyeong Kang, Mimi Kim, Soon-Young Song, Dae Won Jun, Kiseok Jang
OBJECTIVE: To assess the feasibility of proton density fat fraction (PDFF) MRI for estimating hepatic fat fraction with magnetic resonance spectroscopy (MRS) and histology as references and to investigate intrahepatic fat distribution and variability. METHODS: Between November 2014 and September 2015, 85 adults (48 males, 47 females) who underwent MRI-PDFF (n = 139), MRS-PDFF (n = 49) and liver biopsy (n = 29) were enrolled in this study. Data were compared using linear regression...
November 8, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28990974/iodine-and-fat-quantification-for-differentiation-of-adrenal-gland-adenomas-from-metastases-using-third-generation-dual-source-dual-energy-computed-tomography
#17
Simon S Martin, Sebastian Weidinger, Rouben Czwikla, Benjamin Kaltenbach, Moritz H Albrecht, Lukas Lenga, Thomas J Vogl, Julian L Wichmann
OBJECTIVES: The aim of this study was to investigate the value of third-generation dual-source dual-energy computed tomography (DECT) iodine and fat quantification in differentiating adrenal gland adenomas from metastases. MATERIALS AND METHODS: Sixty-two patients (38 men and 24 women; mean age, 69.1 years) underwent clinically indicated DECT of the abdomen on a third-generation dual-source scanner. Examinations were retrospectively included due to detected adrenal masses...
October 3, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28984608/damage-to-the-frontal-aslant-tract-accounts-for-visuo-constructive-deficits-in-alzheimer-s-disease
#18
Laura Serra, Giulia Bechi Gabrielli, Elisa Tuzzi, Barbara Spanò, Giovanni Giulietti, Virginia Failoni, Camillo Marra, Carlo Caltagirone, Giacomo Koch, Mara Cercignani, Marco Bozzali
The frontal aslant tract (FAT) has been described as a bundle connecting the Broca's area to the supplementary motor area (SMA) and the pre-SMA in both hemispheres. The functional properties of this tract and its role in degenerative dementia, such as Alzheimer's disease (AD), still need to be fully clarified. The aim of this study was to explore the microstructural integrity of the FAT in patients with AD and its potential relationship with cognitive functioning. Twenty-three patients with AD and 25 healthy subjects (HS) were enrolled...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28974742/the-relative-contribution-of-metabolic-and-structural-abnormalities-to-diastolic-dysfunction-in-obesity
#19
J J Rayner, R Banerjee, C J Holloway, A J M Lewis, M A Peterzan, J M Francis, S Neubauer, O J Rider
BACKGROUND: Obesity causes diastolic dysfunction, and is one of the leading causes of heart failure with preserved ejection fraction. Myocardial relaxation is determined by both active metabolic processes such as impaired energetic status and steatosis, as well as intrinsic myocardial remodelling. However, the relative contribution of each to diastolic dysfunction in obesity is currently unknown. METHODS: 80 adult subjects (48 male) with no cardiovascular risk factors across a wide range of body mass indices (18...
October 4, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28948164/liver-adiposity-and-metabolic-profile-in-individuals-with-chronic-spinal-cord-injury
#20
Kathleen C Rankin, Laura C O'Brien, Liron Segal, M Rehan Khan, Ashraf S Gorgey
PURPOSE: To quantify liver adiposity using magnetic resonance imaging (MRI) and to determine its association with metabolic profile in men with spinal cord injury (SCI). MATERIALS AND METHODS: MRI analysis of liver adiposity by fat signal fraction (FSF) and visceral adipose tissue (VAT) was completed on twenty participants. Intravenous glucose tolerance test was conducted to measure glucose effectiveness (Sg) and insulin sensitivity (Si). Lipid panel, fasting glucose, glycated hemoglobin (HbA1c), and inflammatory cytokines were also analyzed...
2017: BioMed Research International
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