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Whole-body mri

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https://www.readbyqxmd.com/read/28222414/urinary-steroid-metabolites-in-a-case-of-florid-ectopic-cushing-s-syndrome-and-clinical-correlations
#1
Angelos Kyriacou, Karolina G Stepien, Basil Issa
A 51-year old woman was admitted with multiple cerebral, pulmonary and intra-abdominal abscesses. The combination of apparent immunosuppression, obesity, diabetes mellitus, hypertension, hypokalaemia, osteoporotic fractures and bilateral shoulder avascular necrosis led to a clinical diagnosis of Cushing's syndrome (CS). This was biochemically confirmed as follows: midnight serum cortisol 4275 nmol/L (60-250), non-suppressed overnight dexamethasone suppression test, raised salivary cortisol 716 nmol/L (5-46) and ACTH 639 ng/L (0-46)...
October 2016: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28221241/hyperpolarized-helium-3-diffusion-weighted-magnetic-resonance-imaging-detects-abnormalities-of-lung-structure-in-children-with-bronchopulmonary-dysplasia
#2
Lucia Flors, John P Mugler, Alix Paget-Brown, Deborah K Froh, Eduard E de Lange, James T Patrie, Talissa A Altes
PURPOSE: The aim of the study was to determine whether hyperpolarized He diffusion-weighted magnetic resonance imaging detects abnormalities in the lungs in children with bronchopulmonary dysplasia (BPD) as compared with age-matched normal children. MATERIALS AND METHODS: All experiments were compliant with Health Insurance Portability and Accountability Act (HIPAA) and performed with Food and Drug Administration approval under an IND application. The protocol was approved by our Institutional Review Board, and written informed consent was obtained...
February 17, 2017: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/28219492/microstructural-white-matter-alterations-in-the-corpus-callosum-of-girls-with-conduct-disorder
#3
Willeke Martine Menks, Reto Furger, Claudia Lenz, Lynn Valérie Fehlbaum, Christina Stadler, Nora Maria Raschle
OBJECTIVE: Diffusion tensor imaging (DTI) studies in adolescent conduct disorder (CD) have demonstrated white matter alterations of tracts connecting functionally distinct fronto-limbic regions, but only in boys or mixed-gender samples. So far, no study has investigated white matter integrity in girls with CD on a whole-brain level. Therefore, our aim was to investigate white matter alterations in adolescent girls with CD. METHOD: We collected high-resolution DTI data from 24 girls with CD and 20 typically developing control girls using a 3T magnetic resonance imaging system...
March 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28216327/combined-whole-body-and-multi-parametric-prostate-mri-as-a-single-step-approach-for-the-simultaneous-assessment-of-local-recurrence-and-metastatic-disease-after-radical-prostatectomy
#4
Nicola L Robertson, Evis Sala, Matthias Benz, Jonathan Landa, Peter Scardino, Howard I Scher, Hedvig Hricak, Hebert A Vargas
PURPOSE: To report our initial experience using "whole body and dedicated prostate (WB+P)" MRI as a single exam for the assessment of local recurrence and metastatic disease in patients with suspected recurrent prostate cancer (PCa) after radical prostatectomy (RP). MATERIALS AND METHODS: IRB-approved retrospective single-center study. 76 consecutive patients with clinically suspected recurrent PCa following RP underwent combined WB+P-MRI in a single session (10/2014-01/2016)...
February 16, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28191353/alterations-in-cortical-thickness-and-white-matter-integrity-in-mild-to-moderate-communicating-hydrocephalic-school-aged-children-measured-by-whole-brain-cortical-thickness-mapping-and-dti
#5
Siyu Zhang, Xinjian Ye, Guanghui Bai, Yuchuan Fu, Chuanwan Mao, Aiqin Wu, Xiaozheng Liu, Zhihan Yan
Follow-up observation is required for mild-to-moderate hydrocephalic patients because of the potential damage to brain. However, effects of mild-to-moderate hydrocephalus on gray and white matter remain unclear in vivo. Using structural MRI and diffusion tensor imaging (DTI), current study compared the cortical thickness and white matter integrity between children with mild-to-moderate communicating hydrocephalus and healthy controls. The relationships between cortical changes and intelligence quota were also examined in patients...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/28187778/whole-body-mri-in-pediatric-patients-with-cancer
#6
REVIEW
Marcos Duarte Guimarães, Julia Noschang, Sara Reis Teixeira, Marcel Koenigkam Santos, Henrique Manoel Lederman, Vivian Tostes, Vikas Kundra, Alex Dias Oliveira, Bruno Hochhegger, Edson Marchiori
Cancer is the leading cause of natural death in the pediatric populations of developed countries, yet cure rates are greater than 70% when a cancer is diagnosed in its early stages. Recent advances in magnetic resonance imaging methods have markedly improved diagnostic and therapeutic approaches, while avoiding the risks of ionizing radiation that are associated with most conventional radiological methods, such as computed tomography and positron emission tomography/computed tomography. The advent of whole-body magnetic resonance imaging in association with the development of metabolic- and function-based techniques has led to the use of whole-body magnetic resonance imaging for the screening, diagnosis, staging, response assessment, and post-therapeutic follow-up of children with solid sporadic tumours or those with related genetic syndromes...
February 10, 2017: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://www.readbyqxmd.com/read/28168589/impact-of-pet-acquisition-durations-on-image-quality-and-lesion-detectability-in-whole-body-68-ga-psma-pet-mri
#7
Benjamin Noto, Florian Büther, Katharina Auf der Springe, Nemanja Avramovic, Walter Heindel, Michael Schäfers, Thomas Allkemper, Lars Stegger
BACKGROUND: While (68)Ga-PSMA PET-MRI might be superior to PET-CT with regard to soft tissue assessment in prostate cancer evaluation, it is also known to potentially introduce additional PET image artefacts. Therefore, the impact of PET acquisition duration and attenuation data on artefact occurrence, lesion detectability, and quantification was investigated. To this end, whole-body PET list mode data from 12 patients with prostate cancer were acquired 1 h after injection of 2 MBq/kg [(68)Ga]HBED-CC-PSMA on a hybrid PET-MRI system...
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28167963/physicians-perspectives-on-the-diagnosis-and-treatment-of-chronic-nonbacterial-osteomyelitis
#8
Yongdong Zhao, Fatma Dedeoglu, Polly J Ferguson, Sivia K Lapidus, Ronald M Laxer, Miranda C Bradford, Suzanne C Li
Background/Purpose. Understanding the practices of pediatric rheumatologists in diagnosing and treating chronic nonbacterial osteomyelitis (CNO) can provide important information to guide the development of consensus treatment plans. The objectives of this study were to determine physicians' approaches to (1) diagnosing and monitoring CNO, (2) ordering a bone biopsy, and (3) making treatment decisions. Methods. A survey was distributed among members of the Childhood Arthritis and Rheumatology Research Alliance using a web-based questionnaire...
2017: International Journal of Rheumatology
https://www.readbyqxmd.com/read/28167905/a-possible-role-of-prolonged-whirling-episodes-on-structural-plasticity-of-the-cortical-networks-and-altered-vertigo-perception-the-cortex-of-sufi-whirling-dervishes
#9
Yusuf O Cakmak, Gazanfer Ekinci, Armin Heinecke, Safiye Çavdar
Although minutes of a spinning episode may induce vertigo in the healthy human, as a result of a possible perceptional plasticity, Sufi Whirling Dervishes (SWDs) can spin continuously for an hour without a vertigo perception.This unique long term vestibular system stimulation presents a potential human model to clarify the cortical networks underlying the resistance against vertigo. This study, therefore, aimed to investigate the potential structural cortical plasticity in SWDs. Magnetic resonance imaging (MRI) of 10 SWDs and 10 controls were obtained, using a 3T scanner...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28166147/acrometastasis-of-neuroblastoma-to-the-great-toe-revealed-by-mibg-scan
#10
Kun Zheng, Hongming Zhuang
A 3-year-old boy with history of neuroblastoma underwent I-MIBG scan. The whole-body images showed relatively normal tracer distribution except for mild activity in the right foot, which was located in the first metatarsal on SPECT/CT images. The subsequent MRI scan of the right foot showed infiltration of the metatarsal of the right first toe. The findings were consistent with solitary acrometastasis of neuroblastoma to the great toe.
February 3, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28154019/mib1-index-stratified-assessment-of-dual-tracer-pet-ct-with-68ga-dotatate-and-18f-fdg-and-multimodality-anatomical-imaging-in-metastatic-net-of-unknown-primary-cup-net-scheduled-for-prrt
#11
Nikita Sampathirao, Sandip Basu
AIM: Comparative assessment of dual tracer PET/CT ((68)Ga-DOTATATE and (18)F-FDG) and multimodality anatomical imaging in studying CUP-NETs scheduled for PRRT for: (i) divergence of tracer uptake on dual tracer PET/CT, (ii) detection of primary and (iii) overall lesion detection vis-a-vis tumor proliferation index (Mib1/Ki-67). MATERIALS AND METHODS: Fifty-one patients of CUP-NETs (M:F=25:26, age:22-74 years), histopathologically proven and thoroughly investigated with conventional imaging modalities (USG, CT/ceCT, MRI and EUS, wherever applicable), were retrospective analyzed...
February 2, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/28152253/diffusion-tensor-imaging-of-the-human-calf-variation-of-inter-and-intramuscle-specific-diffusion-parameters
#12
Lara Schlaffke, Robert Rehmann, Martijn Froeling, Rudolf Kley, Martin Tegenthoff, Matthias Vorgerd, Tobias Schmidt-Wilcke
PURPOSE: To investigate to what extent inter- and intramuscular variations of diffusion parameters of human calf muscles can be explained by age, gender, muscle location, and body mass index (BMI) in a specific age group (20-35 years). MATERIALS AND METHODS: Whole calf muscles of 18 healthy volunteers were evaluated. Magnetic resonance imaging (MRI) was performed using a 3T scanner and a 16-channel Torso XL coil. Diffusion-weighted images were acquired to perform fiber tractography and diffusion tensor imaging (DTI) analysis for each muscle of both legs...
February 2, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28142138/three-dimensional-imaging-based-web-application-for-predicting-tracheal-tube-depth-in-preterm-neonates
#13
Raksa Tupprasoot, Dean Langan, J Ciaran Hutchinson, Hannah Barrett, Michael R J Sury, Owen J Arthurs
BACKGROUND: Positioning a tracheal tube (TT) to the correct depth in preterm infants is challenging. Currently, there is no reliable single-predictor model for neonates applicable to the whole range of size or age. OBJECTIVE: In this study, we used post-mortem magnetic resonance imaging (PMMRI) of preterm infants to measure tracheal dimensions and to develop a clinical guide for TT positioning. METHODS: We measured tracheal length (TL) and tracheal diameter (TD) in a cohort of normal neonates and foetuses that underwent PMMRI (cause of death unexplained)...
February 1, 2017: Neonatology
https://www.readbyqxmd.com/read/28133747/on-the-potential-for-rf-heating-in-mri-to-affect-metabolic-rates-and-18-fdg-signal-in-pet-mr-simulations-of-long-duration-maximum-normal-mode-heating
#14
Giuseppe Carluccio, Yu-Shin Ding, Jean Logan, Christopher M Collins
PURPOSE: To examine the possibility that MR-induced RF power deposition (SAR) and the resulting effects on temperature-dependent metabolic rates or perfusion rates might affect observed 18FDG signal in PET/MR. METHODS: Using numerical simulations of the SAR, consequent temperature increase, effect on rates of metabolism or perfusion, and [18FDG] throughout the body, we simulated the potential effect of maximum-allowable whole-body SAR for the entire duration of an hour-long PET/MR scan on observed PET signal for two different 18FDG injection times: one hour before onset of imaging and concurrent with the beginning of imaging...
December 9, 2016: Medical Physics
https://www.readbyqxmd.com/read/28125360/monitoring-total-body-inflammation-and-damage-in-joints-and-entheses-the-first-follow-up-study-of-whole-body-magnetic-resonance-imaging-in-rheumatoid-arthritis
#15
M B Axelsen, I Eshed, M Østergaard, M L Hetland, J M Møller, D V Jensen, S B Krintel, M S Hansen, L Terslev, M Klarlund, R P Poggenborg, L Balding, S J Pedersen
OBJECTIVE: To investigate changes in whole-body magnetic resonance imaging (WBMRI) inflammatory and structural lesions in most joints and entheses in patients with rheumatoid arthritis (RA) treated with adalimumab. METHODS: WBMRI was obtained at weeks 0, 6, 16, and 52 in a 52 week follow-up study of 37 RA patients starting treatment with adalimumab. Readability and reliability of WBMRI were investigated for 76 peripheral joints, 23 discovertebral units, the sacroiliac joints, and 33 entheses...
January 26, 2017: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/28124295/psychosocial-morbidity-in-tp53-mutation-carriers-is-whole-body-cancer-screening-beneficial
#16
Kate A McBride, Mandy L Ballinger, Timothy E Schlub, Mary-Anne Young, Martin H N Tattersall, Judy Kirk, Ros Eeles, Emma Killick, Leslie G Walker, Sue Shanley, David M Thomas, Gillian Mitchell
Germline TP53 mutation carriers are at high risk of developing a range of cancers. Effective cancer risk management is an important issue for these individuals. We assessed the psychosocial impact in TP53 mutation carriers of WB-MRI screening as part of the Surveillance in Multi-Organ Cancer (SMOC+) protocol, measuring their unmet needs, anxiety and depression levels as well as cancer worry using psychological questionnaires and in-depth interviews about their experiences of screening. We present preliminary psychosocial findings from 17 participants during their first 12 months on the trial...
January 25, 2017: Familial Cancer
https://www.readbyqxmd.com/read/28121200/effectiveness-of-whole-body-magnetic-resonance-imaging-for-the-efficacy-of-biologic-anti-rheumatic-drugs-in-patients-with-rheumatoid-arthritis-a-retrospective-pilot-study
#17
Michihito Kono, Tamotsu Kamishima, Shinsuke Yasuda, Keita Sakamoto, Sawako Abe, Atsushi Noguchi, Toshiyuki Watanabe, Yuka Shimizu, Kenji Oku, Toshiyuki Bohgaki, Olga Amengual, Tetsuya Horita, Tatsuya Atsumi
OBJECTIVES: To evaluate the scoring of whole-body magnetic resonance imaging (WBMRI) for efficacy assessment in rheumatoid arthritis (RA) patients receiving biological disease-modifying anti-rheumatic drugs (bDMARDs). METHODS: Thirty consecutive RA patients receiving bDMARDs were included in this retrospective study. Contrast WBMRI was performed before and 1 year after bDMARDs initiation. RESULTS: At baseline, mean age was 57.1 years and mean disease duration was 3...
February 1, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28116518/post-mortem-whole-body-magnetic-resonance-imaging-of-human-fetuses-a-comparison-of-3-t-vs-1-5-t-mr-imaging-with-classical-autopsy
#18
Xin Kang, Mieke M Cannie, Owen J Arthurs, Valerie Segers, Catherine Fourneau, Elisa Bevilacqua, Teresa Cos Sanchez, Neil J Sebire, Jacques C Jani
OBJECTIVE: To prospectively compare diagnostic accuracy of fetal post-mortem whole-body MRI at 3-T vs. 1.5-T. METHODS: Between 2012 and 2015, post-mortem MRI at 1.5-T and 3-T was performed in fetuses after miscarriage/stillbirth or termination. Clinical MRI diagnoses were assessed using a confidence diagnostic score and compared with classical autopsy to derive a diagnostic error score. The relation of diagnostic error for each organ group with gestational age was calculated and 1...
January 23, 2017: European Radiology
https://www.readbyqxmd.com/read/28113455/design-features-and-mutual-compatibility-studies-of-the-time-of-flight-pet-capable-ge-signa-pet-mr-system
#19
Craig S Levin, Sri Harsha Maramraju, Mohammad Mehdi Khalighi, Timothy W Deller, Gaspar Delso, Floris Jansen
A recent entry into the rapidly evolving field of integrated PET/MR scanners is presented in this paper: a whole body hybrid PET/MR system (SIGNA PET/MR, GE Healthcare) capable of simultaneous acquisition of both time-of-flight (TOF) PET and high resolution MR data. The PET ring was integrated into an existing 3T MR system resulting in a (patient) bore opening of 60 cm diameter, with a 25 cm axial FOV. The PET ring is placed between the shielded RF body coil and the gradient coils. The PET detectors are based on silicon photomultipliers coupled to lutetium based scintillators...
March 9, 2016: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28111795/myopathology-in-times-of-modern-imaging
#20
Heinz Jungbluth
Over the last two decades muscle (magnetic resonance) imaging has become an important complementary tool in the diagnosis and differential diagnosis of inherited neuromuscular disorders, particularly in conditions where the pattern of selective muscle involvement is often more predictive of the underlying genetic background than associated clinical and histopathological features. Following an overview of different imaging modalities, the present review will give a concise introduction to systematic image analysis and interpretation in genetic neuromuscular disorders...
January 23, 2017: Neuropathology and Applied Neurobiology
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