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Biomarkers in Psychiatry

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https://www.readbyqxmd.com/read/27918562/resting-state-connectivity-biomarkers-define-neurophysiological-subtypes-of-depression
#1
Andrew T Drysdale, Logan Grosenick, Jonathan Downar, Katharine Dunlop, Farrokh Mansouri, Yue Meng, Robert N Fetcho, Benjamin Zebley, Desmond J Oathes, Amit Etkin, Alan F Schatzberg, Keith Sudheimer, Jennifer Keller, Helen S Mayberg, Faith M Gunning, George S Alexopoulos, Michael D Fox, Alvaro Pascual-Leone, Henning U Voss, B J Casey, Marc J Dubin, Conor Liston
Biomarkers have transformed modern medicine but remain largely elusive in psychiatry, partly because there is a weak correspondence between diagnostic labels and their neurobiological substrates. Like to other neuropsychiatric disorders, depression is not a unitary disease, but rather a heterogeneous syndrome that encompasses varied, co-occurring symptoms and divergent responses to treatment. By using functional magnetic resonance imaging (fMRI) in a large multisite sample (n = 1,188), we show here that patients with depression can be subdivided into four neurophysiological subtypes ('biotypes') defined by distinct patterns of dysfunctional connectivity in limbic and frontostriatal networks...
December 5, 2016: Nature Medicine
https://www.readbyqxmd.com/read/27843151/a-dna-methylation-biomarker-of-alcohol-consumption
#2
C Liu, R E Marioni, Å K Hedman, L Pfeiffer, P-C Tsai, L M Reynolds, A C Just, Q Duan, C G Boer, T Tanaka, C E Elks, S Aslibekyan, J A Brody, B Kühnel, C Herder, L M Almli, D Zhi, Y Wang, T Huan, C Yao, M M Mendelson, R Joehanes, L Liang, S-A Love, W Guan, S Shah, A F McRae, A Kretschmer, H Prokisch, K Strauch, A Peters, P M Visscher, N R Wray, X Guo, K L Wiggins, A K Smith, E B Binder, K J Ressler, M R Irvin, D M Absher, D Hernandez, L Ferrucci, S Bandinelli, K Lohman, J Ding, L Trevisi, S Gustafsson, J H Sandling, L Stolk, A G Uitterlinden, I Yet, J E Castillo-Fernandez, T D Spector, J D Schwartz, P Vokonas, L Lind, Y Li, M Fornage, D K Arnett, N J Wareham, N Sotoodehnia, K K Ong, J B J van Meurs, K N Conneely, A A Baccarelli, I J Deary, J T Bell, K E North, Y Liu, M Waldenberger, S J London, E Ingelsson, D Levy
The lack of reliable measures of alcohol intake is a major obstacle to the diagnosis and treatment of alcohol-related diseases. Epigenetic modifications such as DNA methylation may provide novel biomarkers of alcohol use. To examine this possibility, we performed an epigenome-wide association study of methylation of cytosine-phosphate-guanine dinucleotide (CpG) sites in relation to alcohol intake in 13 population-based cohorts (ntotal=13 317; 54% women; mean age across cohorts 42-76 years) using whole blood (9643 European and 2423 African ancestries) or monocyte-derived DNA (588 European, 263 African and 400 Hispanic ancestry) samples...
November 15, 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/27816667/correlation-between-brain-damage-associated-biomarkers-and-medication-in-psychiatric-inpatients-a-cross-sectional-study
#3
Madoka Yoshida, Tetsuto Kanzaki, Mutsumi Mizoi, Mizuho Nakamura, Takeshi Uemura, Seisuke Mimori, Yoriyasu Uju, Keisuke Sekine, Yukihiro Ishii, Taro Yoshimi, Reiko Yasui, Asuka Yasukawa, Mamoru Sato, Seiko Okamoto, Tetsuya Hisaoka, Masafumi Miura, Shun Kusanishi, Kanako Murakami, Chieko Nakano, Yasuhiko Mizuta, Shunichi Mishima, Tatsuro Hayakawa, Kazumi Tsukada, Keiko Kashiwagi, Kazuei Igarashi
BACKGROUND: We clarified the correlation between brain damage, associated biomarkers and medication in psychiatric patients, because patients with schizophrenia have an increased risk of stroke. METHODS: The cross-sectional study was performed from January 2013 to December 2015. Study participants were 96 hospitalized patients (41 men and 55 women) in the Department of Psychiatry at Kohnodai Hospital, National Center for Global Health and Medicine, Ichikawa, Chiba, Japan...
November 3, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27810706/how-to-measuring-blood-cytokines-in-biological-psychiatry-using-commercially-available-multiplex-immunoassays
#4
Raoul Belzeaux, Marie-Noëlle Lefebvre, Anne Lazzari, Tifenn Le Carpentier, Julia-Lou Consoloni, Xavier Zendjidjian, Mocrane Abbar, Philippe Courtet, Jean Naudin, José Boucraut, Pierre Gressens, Nicolas Glaichenhaus, El Chérif Ibrahim
Cytokines produced by both immune and non-immune cells are likely to play roles in the development and/or progression of psychiatric disorders. Indeed, many investigators have compared the blood cytokine levels in psychiatric patients with those of healthy controls or monitored their levels in patients during disease progression to identify biomarkers. Nevertheless, very few studies have confirmed that such cytokines remain stable in healthy individuals through periods of weeks and months. This is an important issue to consider before using blood cytokine levels as biomarkers of disease traits, disease state, or treatment response...
January 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27788673/immuno-psychiatry-an-agenda-for-clinical-practice-and-innovative-research
#5
EDITORIAL
Marion Leboyer, Michael Berk, Robert H Yolken, Ryad Tamouza, David Kupfer, Laurent Groc
BACKGROUND: The diagnostic scheme for psychiatric disorders is currently based purely on descriptive nomenclature given that biomarkers subtypes and clearly defined causal mechanisms are lacking for the vast majority of disorders. The emerging field of "immuno-psychiatry" has the potential to widen the exploration of a mechanism-based nosology, possibly leading to the discovery of more effective personalised treatment strategies. DISCUSSION: Disturbances in immuno-inflammatory and related systems have been implicated in the aetiology, pathophysiology, phenomenology and comorbidity of several psychiatric disorders, including major mood disorders and schizophrenia...
October 28, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27784534/toward-understanding-thalamocortical-dysfunction-in-schizophrenia-through-computational-models-of-neural-circuit-dynamics
#6
REVIEW
John D Murray, Alan Anticevic
The thalamus is implicated in the neuropathology of schizophrenia, and multiple modalities of noninvasive neuroimaging provide converging evidence for altered thalamocortical dynamics in the disorder, such as functional connectivity and oscillatory power. However, it remains a challenge to link these neuroimaging biomarkers to underlying neural circuit mechanisms. One potential path forward is a "Computational Psychiatry" approach that leverages computational models of neural circuits to make predictions for the dynamical impact dynamical impact on specific thalamic disruptions hypothesized to occur in the pathophysiology of schizophrenia...
October 23, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27783066/the-search-for-imaging-biomarkers-in-psychiatric-disorders
#7
Anissa Abi-Dargham, Guillermo Horga
The field of medicine is moving toward the use of biomarkers for the optimization of individualized care. This is a particular challenge for the field of psychiatry, in which diagnosis is based on a descriptive collection of behaviors without the availability of any objective test to stratify patients. Neuroimaging techniques such as molecular imaging with positron-emission tomography (PET) or structural and functional magnetic resonance imaging (MRI) provide an opportunity to bring psychiatry from an era of subjective descriptive classification into objective and tangible brain-based measures...
October 26, 2016: Nature Medicine
https://www.readbyqxmd.com/read/27698428/predicting-the-functional-states-of-human-ipsc-derived-neurons-with-single-cell-rna-seq-and-electrophysiology
#8
C Bardy, M van den Hurk, B Kakaradov, J A Erwin, B N Jaeger, R V Hernandez, T Eames, A A Paucar, M Gorris, C Marchand, R Jappelli, J Barron, A K Bryant, M Kellogg, R S Lasken, B P F Rutten, H W M Steinbusch, G W Yeo, F H Gage
Human neural progenitors derived from pluripotent stem cells develop into electrophysiologically active neurons at heterogeneous rates, which can confound disease-relevant discoveries in neurology and psychiatry. By combining patch clamping, morphological and transcriptome analysis on single-human neurons in vitro, we defined a continuum of poor to highly functional electrophysiological states of differentiated neurons. The strong correlations between action potentials, synaptic activity, dendritic complexity and gene expression highlight the importance of methods for isolating functionally comparable neurons for in vitro investigations of brain disorders...
November 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/27573877/novel-roles-of-amyloid-beta-precursor-protein-metabolites-in-fragile-x-syndrome-and-autism
#9
REVIEW
C J Westmark, D K Sokol, B Maloney, D K Lahiri
Fragile X syndrome (FXS) is the most common form of inherited intellectual disability and is associated with up to 5% of autism cases. Several promising drugs are in preclinical testing for FXS; however, bench-to-bedside plans for the clinic are severely limited due to lack of validated biomarkers and outcome measures. Published work from our laboratories has demonstrated altered levels of amyloid-beta (Aβ) precursor protein (APP) and its metabolites in FXS and idiopathic autism. Westmark and colleagues have focused on β-secretase (amyloidogenic) processing and the accumulation of Aβ peptides in adult FXS models, whereas Lahiri and Sokol have studied α-secretase (non-amyloidogenic or anabolic) processing and altered levels of sAPPα and Aβ in pediatric autism and FXS...
October 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/27566494/does-environmental-exposure-to-the-greenhouse-gas-n2o-contribute-to-etiological-factors-in-neurodevelopmental-disorders-a-mini-review-of-the-evidence
#10
Keith Fluegge
BACKGROUND: Neurodevelopmental disorders are increasing in prevalence worldwide. Previous work suggests that exposure to the environmental air pollutant and greenhouse gas - nitrous oxide (N2O) - may be an etiological factor in neurodevelopmental disorders through the targeting of several neural correlates. METHODOLOGY: While a number of recent systematic reviews have addressed the role of general anesthesia in the surgical setting and neurodevelopmental outcomes, a narrative mini-review was conducted to first define and characterize the relevant variables (i...
August 18, 2016: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/27564242/personalized-medicine-in-psychiatry
#11
Ida Kim Wium-Andersen, Maj Vinberg, Lars Vedel Kessing, Roger S McIntyre
BACKGROUND: Personalized medicine is a model in which a patient's unique clinical, genetic, and environmental characteristics are the basis for treatment and prevention. Aim, method, and results: This review aims to describe the current tools, phenomenological features, clinical risk factors, and biomarkers used to provide personalized medicine. Furthermore, this study describes the target areas in which they can be applied including diagnostics, treatment selection and response, assessment of risk of side-effects, and prevention...
August 26, 2016: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/27536015/biomarkers-in-psychiatry-a-critique
#12
Ganesan Venkatasubramanian, Matcheri S Keshavan
No abstract text is available yet for this article.
March 2016: Annals of Neurosciences
https://www.readbyqxmd.com/read/27504098/can-interoception-improve-the-pragmatic-search-for-biomarkers-in-psychiatry
#13
REVIEW
Sahib S Khalsa, Rachel C Lapidus
Disrupted interoception is a prominent feature of the diagnostic classification of several psychiatric disorders. However, progress in understanding the interoceptive basis of these disorders has been incremental, and the application of interoception in clinical treatment is currently limited to panic disorder. To examine the degree to which the scientific community has recognized interoception as a construct of interest, we identified and individually screened all articles published in the English language on interoception and associated root terms in Pubmed, Psychinfo, and ISI Web of Knowledge...
2016: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/27483380/micrornas-as-biomarkers-for-major-depression-a-role-for-let-7b-and-let-7c
#14
A Gururajan, M E Naughton, K A Scott, R M O'Connor, G Moloney, G Clarke, J Dowling, A Walsh, F Ismail, G Shorten, L Scott, D M McLoughlin, J F Cryan, T G Dinan
There is a growing emphasis in the field of psychiatry on the need to identify candidate biomarkers to aid in diagnosis and clinical management of depression, particularly with respect to predicting response to specific therapeutic strategies. MicroRNAs are small nucleotide sequences with the ability to regulate gene expression at the transcriptomic level and emerging evidence from a range of studies has highlighted their biomarker potential. Here we compared healthy controls (n=20) with patients diagnosed with major depression (n=40) and who were treatment-resistant to identify peripheral microRNA biomarkers, which could be used for diagnosis and to predict response to electroconvulsive therapy (ECT) and ketamine (KET) infusions, treatments that have previously shown to be effective in treatment-resistant depression (TRD)...
2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27480489/reduced-pcreb-in-alzheimer-s-disease-prefrontal-cortex-is-reflected-in-peripheral-blood-mononuclear-cells
#15
N Bartolotti, D A Bennett, O Lazarov
Cyclic-AMP response element-binding protein (CREB) signaling has a critical role in the formation of memories. CREB signaling is dysfunctional in the brains of mouse models of Alzheimer's disease (AD), and evidence suggests that CREB signaling may be disrupted in human AD brains as well. Here, we show that both CREB and its activated form pCREB-Ser(133) (pCREB) are reduced in the prefrontal cortex of AD patients. Similarly, the transcription cofactors CREB-binding protein (CBP) and p300 are reduced in the prefrontal cortex of AD patients, indicating additional dysfunction of CREB signaling in AD...
September 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/27475757/blood-biomarkers-in-psychiatry
#16
EDITORIAL
The Lancet Psychiatry
No abstract text is available yet for this article.
August 2016: Lancet Psychiatry
https://www.readbyqxmd.com/read/27458391/editorial-frontiers-in-brain-based-therapeutic-interventions-and-biomarker-research-in-child-and-adolescent-psychiatry
#17
Paul E Croarkin, Stephanie H Ameis
No abstract text is available yet for this article.
2016: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/27419272/biological-markers-for-anxiety-disorders-ocd-and-ptsd-a-consensus-statement-part-ii-neurochemistry-neurophysiology-and-neurocognition
#18
Borwin Bandelow, David Baldwin, Marianna Abelli, Blanca Bolea-Alamanac, Michel Bourin, Samuel R Chamberlain, Eduardo Cinosi, Simon Davies, Katharina Domschke, Naomi Fineberg, Edna Grünblatt, Marek Jarema, Yong-Ku Kim, Eduard Maron, Vasileios Masdrakis, Olya Mikova, David Nutt, Stefano Pallanti, Stefano Pini, Andreas Ströhle, Florence Thibaut, Matilde M Vaghi, Eunsoo Won, Dirk Wedekind, Adam Wichniak, Jade Woolley, Peter Zwanzger, Peter Riederer
OBJECTIVE: Biomarkers are defined as anatomical, biochemical or physiological traits that are specific to certain disorders or syndromes. The objective of this paper is to summarise the current knowledge of biomarkers for anxiety disorders, obsessive-compulsive disorder (OCD) and posttraumatic stress disorder (PTSD). METHODS: Findings in biomarker research were reviewed by a task force of international experts in the field, consisting of members of the World Federation of Societies for Biological Psychiatry Task Force on Biological Markers and of the European College of Neuropsychopharmacology Anxiety Disorders Research Network...
July 15, 2016: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/27403679/biological-markers-for-anxiety-disorders-ocd-and-ptsd-a-consensus-statement-part-i-neuroimaging-and-genetics
#19
Borwin Bandelow, David Baldwin, Marianna Abelli, Carlo Altamura, Bernardo Dell'Osso, Katharina Domschke, Naomi A Fineberg, Edna Grünblatt, Marek Jarema, Eduard Maron, David Nutt, Stefano Pini, Matilde M Vaghi, Adam Wichniak, Gwyneth Zai, Peter Riederer
OBJECTIVES: Biomarkers are defined as anatomical, biochemical or physiological traits that are specific to certain disorders or syndromes. The objective of this paper is to summarise the current knowledge of biomarkers for anxiety disorders, obsessive-compulsive disorder (OCD) and post-traumatic stress disorder (PTSD). METHODS: Findings in biomarker research were reviewed by a task force of international experts in the field, consisting of members of the World Federation of Societies for Biological Psychiatry Task Force on Biological Markers and of the European College of Neuropsychopharmacology Anxiety Disorders Research Network...
August 2016: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/27380626/identifying-specific-clinical-symptoms-of-behavioral-variant-frontotemporal-dementia-versus-differential-psychiatric-disorders-in-patients-presenting-with-a-late-onset-frontal-lobe-syndrome
#20
Annemiek Dols, Saskia van Liempt, Flora Gossink, Welmoed A Krudop, Sietske Sikkes, Yolande A L Pijnenburg, Max L Stek
OBJECTIVE: Early differentiation between psychiatric disorders and behavioral variant frontotemporal dementia (bvFTD) is of paramount importance in patients with the late-onset frontal lobe syndrome. As bvFTD in patients will deteriorate, psychiatric disorders are treatable. To date, misdiagnosis often occurs due to an overlap of symptoms and lack of specific biomarkers. The aim of our study was to investigate whether specific symptoms could separate bvFTD from psychiatric disorders. METHODS: In a naturalistic, prospective, multicenter study, 137 patients (aged 45-75 years, 72% male) with a late-onset frontal lobe syndrome were included based on their scores on the Frontal Behavioral Inventory (FBI) and the Stereotypy Rating Inventory (SRI) from April 2011 to June 2013...
July 5, 2016: Journal of Clinical Psychiatry
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