keyword
MENU ▼
Read by QxMD icon Read
search

Biomarkers in Psychiatry

keyword
https://www.readbyqxmd.com/read/29374800/blood-based-biomarkers-predicting-response-to-antidepressants
#1
REVIEW
Yasmin Busch, Andreas Menke
Major depressive disorder is a common, serious and in some cases, life-threatening condition and affects approximately 350 million people globally. Although there is effective treatment available for it, more than 50% of the patients fail to respond to the first antidepressant they receive. The selection of a distinct treatment is still exclusively based on clinical judgment without incorporating lab-derived objective measures. However, there is growing evidence of biomarkers that it helps to improve diagnostic processes and treatment algorithms...
January 27, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29371263/tulsa-1000-a-naturalistic-study-protocol-for-multilevel-assessment-and-outcome-prediction-in-a-large-psychiatric-sample
#2
Teresa A Victor, Sahib S Khalsa, W Kyle Simmons, Justin S Feinstein, Jonathan Savitz, Robin L Aupperle, Hung-Wen Yeh, Jerzy Bodurka, Martin P Paulus
INTRODUCTION: Although neuroscience has made tremendous progress towards understanding the basic neural circuitry underlying important processes such as attention, memory and emotion, little progress has been made in applying these insights to psychiatric populations to make clinically meaningful treatment predictions. The overall aim of the Tulsa 1000 (T-1000) study is to use the NIMH Research Domain Criteria framework in order to establish a robust and reliable dimensional set of variables that quantifies the positive and negative valence, cognition and arousal domains, including interoception, to generate clinically useful treatment predictions...
January 24, 2018: BMJ Open
https://www.readbyqxmd.com/read/29363463/the-psychoexposome-a-holistic-perspective-beyond-health-and-disease
#3
María-Teresa Colomina, Fernando Sánchez-Santed, Nélida M Conejo, Paloma Collado, Alicia Salvador, Milagros Gallo, Helena Pinos, Cosme Salas, José F Navarro, Ana Adán, Arantza Azpiroz, Jorge L Arias
BACKGROUND: The concept of the exposome has emerged as a new strategy for studying all environmental exposures throughout an individual’s life and their impact on human health. Nowadays, electronic devices are available to collect data about an individual’s geolocation, biological function, or exposure biomarkers. The appearance of “omic” sciences and advances in bioinformatics have allowed massive data-gathering and analysis from various scientific fields. OBJECTIVE: to propose the term Psychoexposome in line with the concept of the exposome from the field of environmental sciences...
February 2018: Psicothema
https://www.readbyqxmd.com/read/29311665/hippocampal-dysfunction-in-the-pathophysiology-of-schizophrenia-a-selective-review-and-hypothesis-for-early-detection-and-intervention
#4
J A Lieberman, R R Girgis, G Brucato, H Moore, F Provenzano, L Kegeles, D Javitt, J Kantrowitz, M M Wall, C M Corcoran, S A Schobel, S A Small
Scientists have long sought to characterize the pathophysiologic basis of schizophrenia and develop biomarkers that could identify the illness. Extensive postmortem and in vivo neuroimaging research has described the early involvement of the hippocampus in the pathophysiology of schizophrenia. In this context, we have developed a hypothesis that describes the evolution of schizophrenia-from the premorbid through the prodromal stages to syndromal psychosis-and posits dysregulation of glutamate neurotransmission beginning in the CA1 region of the hippocampus as inducing attenuated psychotic symptoms and initiating the transition to syndromal psychosis...
January 9, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29310970/lithium-stress-and-resilience-in-bipolar-disorder-deciphering-this-key-homeostatic-synaptic-plasticity-regulator
#5
REVIEW
Rodrigo Machado-Vieira
BACKGROUND: Lithium is the lightest metal and the only mood stabilizer that has been used for over half a century for the treatment of bipolar disorder (BD). As a small ion, lithium is omnipresent, and consequently, its molecular mechanisms and targets are widespread. Currently, lithium is a crucial pharmacotherapy for the treatment of acute mood episodes, prophylactic therapy, and suicide prevention in BD. Besides, lithium blood level is the most widely used biomarker in clinical psychiatry...
December 22, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29306698/gender-differences-in-c-reactive-protein-and-homocysteine-modulation-of-cognitive-performance-and-real-world-functioning-in-bipolar-disorder
#6
M Sanchez-Autet, B Arranz, G Safont, P Sierra, A Garcia-Blanco, L de la Fuente, M Garriga, M P García-Portilla
BACKGROUND: Cognitive and psychosocial impairment has been associated with increased levels of C-reactive protein (CRP) and homocysteine in bipolar disorder, but gender differences have seldom been studied. METHODS: Two hundred and twenty-four bipolar outpatients were included. Cognitive performance was assessed through the Screen for Cognitive Impairment in Psychiatry (SCIP). Psychosocial functioning was evaluated using the Functioning Assessment Short Test (FAST) and the General Assessment of Functioning (GAF)...
December 27, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29258528/social-inequality-scientific-inequality-and-the-future-of-mental-illness
#7
REVIEW
Charles E Dean
BACKGROUND: Despite five decades of increasingly elegant studies aimed at advancing the pathophysiology and treatment of mental illness, the results have not met expectations. Diagnoses are still based on observation, the clinical history, and an outmoded diagnostic system that stresses the historic goal of disease specificity. Psychotropic drugs are still based on molecular targets developed decades ago, with no increase in efficacy. Numerous biomarkers have been proposed, but none have the requisite degree of sensitivity and specificity, and therefore have no usefulness in the clinic...
December 19, 2017: Philosophy, Ethics, and Humanities in Medicine: PEHM
https://www.readbyqxmd.com/read/29218677/40%C3%A2-hz-auditory-steady-state-response-the-impact-of-handedness-and-gender
#8
Sigita Melynyte, Evaldas Pipinis, Vaida Genyte, Aleksandras Voicikas, Tonia Rihs, Inga Griskova-Bulanova
The 40 Hz auditory steady-state response (ASSR) is a periodic response to a periodic stimulation. Its sources are located in the primary auditory cortex and the asymmetry of the planum temporale has previously been associated with hand preference and gender-related differences; thus subject's handedness and gender could potentially influence ASSRs. Nevertheless, electrophysiological studies of ASSRs are mainly dominated by right-handed participants and the observed findings can only be generalized to the right-handed populations...
December 7, 2017: Brain Topography
https://www.readbyqxmd.com/read/29203852/the-dynamics-of-stress-a-longitudinal-mri-study-of-rat-brain-structure-and-connectome
#9
R Magalhães, D A Barrière, A Novais, F Marques, P Marques, J Cerqueira, J C Sousa, A Cachia, F Boumezbeur, M Bottlaender, T M Jay, S Mériaux, N Sousa
Stress is a well-established trigger for a number of neuropsychiatric disorders, as it alters both structure and function of several brain regions and its networks. Herein, we conduct a longitudinal neuroimaging study to assess how a chronic unpredictable stress protocol impacts the structure of the rat brain and its functional connectome in both high and low responders to stress. Our results reveal the changes that stress triggers in the brain, with structural atrophy affecting key regions such as the prelimbic, cingulate, insular and retrosplenial, somatosensory, motor, auditory and perirhinal/entorhinal cortices, the hippocampus, the dorsomedial striatum, nucleus accumbens, the septum, the bed nucleus of the stria terminalis, the thalamus and several brain stem nuclei...
December 5, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/29203847/reconceptualization-of-translocator-protein-as-a-biomarker-of-neuroinflammation-in-psychiatry
#10
T Notter, J M Coughlin, A Sawa, U Meyer
A great deal of interest in psychiatric research is currently centered upon the pathogenic role of inflammatory processes. Positron emission tomography (PET) using radiolabeled ligands selective for the 18 kDa translocator protein (TSPO) has become the most widely used technique to assess putative neuroimmune abnormalities in vivo. Originally used to detect discrete neurotoxic damages, TSPO has generally turned into a biomarker of 'neuroinflammation' or 'microglial activation'. Psychiatric research has mostly accepted these denotations of TSPO, even if they may be inadequate and misleading under many pathological conditions...
January 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29198278/brain-based-biomarkers-for-the-treatment-of-depression-evolution-of-an-idea
#11
Allison C Waters, Helen S Mayberg
An ambition of depression biomarker research is to augment psychometric and cognitive assessment of clinically relevant phenomena with neural measures. Although such applications have been slow to arrive, we observe a steady evolution of the idea and anticipate emerging technologies with some optimism. To highlight critical themes and innovations in depression biomarker research, we take as our point of reference a specific research narrative. We begin with an early model of frontal-limbic dysfunction, which represents a conceptual shift from localized pathology to understanding symptoms as an emergent property of distributed networks...
October 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/29150144/atypical-depression-and-non-atypical-depression-is-hpa-axis-function-a-biomarker-a-systematic-review
#12
REVIEW
Mario F Juruena, Mariia Bocharova, Bruno Agustini, Allan H Young
BACKGROUND: The link between the abnormalities of the Hypothalamic-pituitary-adrenal (HPA) axis and depression has been one of the most consistently reported findings in psychiatry. At the same time, multiple studies have demonstrated a stronger association between the increased activation of HPA-axis and melancholic, or endogenous depression subtype. This association has not been confirmed for the atypical subtype, and some researchers have suggested that as an antinomic depressive subtype, it may be associated with the opposite type, i...
October 6, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29148047/plasma-copeptin-levels-in-patients-with-restless-legs-syndrome
#13
S Topaloglu Tuac, S Ozben, M Koseoglu Bitnel, A Koksal, E Kucuksayan, A Hanikoğlu, T Ozben
OBJECTIVES: Copeptin, the C-terminal fragment of antidiuretic hormone, is a new biomarker that has been found to be elevated in several disorders and could be related with prognosis. This study aimed to compare plasma copeptin levels in patients with restless legs syndrome (RLS) with healthy individuals and to investigate whether plasma copeptin levels were associated with the severity of disease. MATERIAL AND METHODS: 41 patients with primary RLS, who were followed in Bakirkoy Psychiatry and Neurology Research and Training Hospital and 41 age- and sex-matched healthy individuals were included into the study...
November 17, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29133955/chemokines-in-depression-in-health-and-in-inflammatory-illness-a-systematic-review-and-meta-analysis
#14
REVIEW
S P Leighton, L Nerurkar, R Krishnadas, C Johnman, G J Graham, J Cavanagh
Inflammatory illness is associated with depression. Preclinical work has shown that chemokines are linked with peripheral-central crosstalk and may be important in mediating depressive behaviours. We sought to establish what evidence exists that differences in blood or cerebrospinal fluid chemokine concentration discriminate between individuals with depression and those without. Following PRISMA guidelines, we systematically searched Embase, PsycINFO and Medline databases. We included participants with physical illness for subgroup analysis, and excluded participants with comorbid psychiatric diagnoses...
November 14, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/29133948/increased-hippocampal-tail-volume-predicts-depression-status-and-remission-to-anti-depressant-medications-in-major-depression
#15
J J Maller, K Broadhouse, A J Rush, E Gordon, S Koslow, S M Grieve
Studies of patients with major depressive disorder (MDD) have consistently reported reduced hippocampal volumes; however, the exact pattern of these volume changes in specific anatomical subfields and their functional significance is unclear. We sought to clarify the relationship between hippocampal tail volumes and (i) a diagnosis of MDD, and (ii) clinical remission to anti-depressant medications (ADMs). Outpatients with nonpsychotic MDD (n=202) based on DSM-IV criteria and a 17-item Hamilton Rating Scale for Depression (HRSD17) score ⩾16 underwent pretreatment magnetic resonance imaging as part of the international Study to Predict Optimized Treatment for Depression (iSPOT-D)...
November 14, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/29076399/cerebrospinal-fluid-and-blood-biomarkers-for-neurodegenerative-dementias-an-update-of-the-consensus-of-the-task-force-on-biological-markers-in-psychiatry-of-the-world-federation-of-societies-of-biological-psychiatry
#16
Piotr Lewczuk, Peter Riederer, Sid E O'Bryant, Marcel M Verbeek, Bruno Dubois, Pieter Jelle Visser, Kurt A Jellinger, Sebastiaan Engelborghs, Alfredo Ramirez, Lucilla Parnetti, Clifford R Jack, Charlotte E Teunissen, Harald Hampel, Alberto Lleó, Frank Jessen, Lidia Glodzik, Mony J de Leon, Anne M Fagan, José Luis Molinuevo, Willemijn J Jansen, Bengt Winblad, Leslie M Shaw, Ulf Andreasson, Markus Otto, Brit Mollenhauer, Jens Wiltfang, Martin R Turner, Inga Zerr, Ron Handels, Alexander G Thompson, Gunilla Johansson, Natalia Ermann, John Q Trojanowski, Ilker Karaca, Holger Wagner, Patrick Oeckl, Linda van Waalwijk van Doorn, Maria Bjerke, Dimitrios Kapogiannis, H Bea Kuiperij, Lucia Farotti, Yi Li, Brian A Gordon, Stéphane Epelbaum, Stephanie J B Vos, Catharina J M Klijn, William E Van Nostrand, Carolina Minguillon, Matthias Schmitz, Carla Gallo, Andrea Lopez Mato, Florence Thibaut, Simone Lista, Daniel Alcolea, Henrik Zetterberg, Kaj Blennow, Johannes Kornhuber
In the 12 years since the publication of the first Consensus Paper of the WFSBP on biomarkers of neurodegenerative dementias, enormous advancement has taken place in the field, and the Task Force takes now the opportunity to extend and update the original paper. New concepts of Alzheimer's disease (AD) and the conceptual interactions between AD and dementia due to AD were developed, resulting in two sets for diagnostic/research criteria. Procedures for pre-analytical sample handling, biobanking, analyses and post-analytical interpretation of the results were intensively studied and optimised...
October 27, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29038767/evaluation-of-plasma-cytokines-in-patients-with-cocaine-use-disorders-in-abstinence-identifies-transforming-growth-factor-alpha-tgf%C3%AE-as-a-potential-biomarker-of-consumption-and-dual-diagnosis
#17
Rosa Maza-Quiroga, Nuria García-Marchena, Pablo Romero-Sanchiz, Vicente Barrios, María Pedraz, Antonia Serrano, Raquel Nogueira-Arjona, Juan Jesus Ruiz, Maribel Soria, Rafael Campos, Julie Ann Chowen, Jesus Argente, Marta Torrens, Meritxell López-Gallardo, Eva María Marco, Fernando Rodríguez de Fonseca, Francisco Javier Pavón, Pedro Araos
BACKGROUND: Cocaine use disorder (CUD) is a complex health condition, especially when it is accompanied by comorbid psychiatric disorders (dual diagnosis). Dual diagnosis is associated with difficulties in the stratification and treatment of patients. One of the major challenges in clinical practice of addiction psychiatry is the lack of objective biological markers that indicate the degree of consumption, severity of addiction, level of toxicity and response to treatment in patients with CUD...
2017: PeerJ
https://www.readbyqxmd.com/read/28986182/on-the-transdiagnostic-nature-of-peripheral-biomarkers-in-major-psychiatric-disorders-a-systematic-review
#18
REVIEW
Jairo Vinícius Pinto, Thiago C Moulin, Olavo B Amaral
The search for biomarkers has been a leading endeavor in biological psychiatry. To analyze its evolution over the years, we performed a systematic review to evaluate (a) the most studied peripheral molecular markers in major psychiatric disorders, (b) the main features of studies proposing them as biomarkers and (c) whether their patterns of variation are similar across disorders. Of the six molecules most commonly studied as plasmatic markers of schizophrenia, major depressive disorder or bipolar disorder, five (BDNF, TNF-alpha, IL-6, C-reactive protein and cortisol) were the same across diagnoses...
October 3, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28942195/short-overview-on-metabolomic-approach-and-redox-changes-in-psychiatric-disorders
#19
REVIEW
Gordana Nedic Erjavec, Marcela Konjevod, Matea Nikolac Perkovic, Dubravka Svob Strac, Lucija Tudor, Coral Barbas, Tilman Grune, Neven Zarkovic, Nela Pivac
Schizophrenia, depression and posttraumatic stress disorder (PTSD) are severe mental disorders and complicated diagnostic entities, due to their phenotypic, biological and genetic heterogeneity, unknown etiology, and poorly understood alterations in biological pathways and biological mechanisms. Disturbed homeostasis between overproduction of oxidant species, overcoming redox regulation and a lack of cellular antioxidant defenses, resulting in free radical-mediated pathology and subsequent neurotoxicity contributes to development of depression, schizophrenia and PTSD, their heterogeneous clinical presentation and resistance to treatment...
September 6, 2017: Redox Biology
https://www.readbyqxmd.com/read/28937340/research-domain-criteria-as-psychiatric-nosology
#20
Faisal Akram, James Giordano
Diagnostic classification systems in psychiatry have continued to rely on clinical phenomenology, despite limitations inherent in that approach. In view of these limitations and recent progress in neuroscience, the National Institute of Mental Health (NIMH) has initiated the Research Domain Criteria (RDoC) project to develop a more neuroscientifically based system of characterizing and classifying psychiatric disorders. The RDoC initiative aims to transform psychiatry into an integrative science of psychopathology in which mental illnesses will be defined as involving putative dysfunctions in neural nodes and networks...
October 2017: Cambridge Quarterly of Healthcare Ethics: CQ: the International Journal of Healthcare Ethics Committees
keyword
keyword
7315
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"