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https://www.readbyqxmd.com/read/28735495/neuroanatomical-and-resting-state-eeg-power-correlates-of-central-hearing-loss-in-older-adults
#1
Nathalie Giroud, Sarah Hirsiger, Raphaela Muri, Andrea Kegel, Norbert Dillier, Martin Meyer
To gain more insight into central hearing loss, we investigated the relationship between cortical thickness and surface area, speech-relevant resting state EEG power, and above-threshold auditory measures in older adults and younger controls. Twenty-three older adults and 13 younger controls were tested with an adaptive auditory test battery to measure not only traditional pure-tone thresholds, but also above individual thresholds of temporal and spectral processing. The participants' speech recognition in noise (SiN) was evaluated, and a T1-weighted MRI image obtained for each participant...
July 22, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28726546/nanotopographic-influence-on-the-in-vitro-behavior-of-induced-pluripotent-stem-cells
#2
Ji-Yun Ko, Hyun-Jik Oh, Jimin Lee, Gun-Il Im
While the influence of nanotopography on stem cell behavior have been extensively investigated on adult stem cells, far fewer studies have investigated the interaction of induced pluripotent stem cells (iPSC) with various nanotopographical patterns. The purpose of this study was to identify nanopatterns that can influence the stemness and proliferation as well as the adhesive properties in iPSCs, and thereby explore the feasibility of applying these nano-features for regenerative medicine. Three kinds of nanopatterns were fabricated from polydimethylsiloxane (PDMS) membranes, irregular patterned membrane (IPM), groove patterned membrane (GPM), and post patterned membrane (PPM), in addition to flat patterned membrane (FPM) which did not have any nanotopographic features and was used as the control pattern...
July 20, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28723924/a-context-for-the-last-neandertals-of-interior-iberia-los-casares-cave-revisited
#3
Manuel Alcaraz-Castaño, Javier Alcolea-González, Martin Kehl, Rosa-María Albert, Javier Baena-Preysler, Rodrigo de Balbín-Behrmann, Felipe Cuartero, Gloria Cuenca-Bescós, Fernando Jiménez-Barredo, José-Antonio López-Sáez, Raquel Piqué, David Rodríguez-Antón, José Yravedra, Gerd-Christian Weniger
INTRODUCTION AND OBJECTIVES: Although the Iberian Peninsula is a key area for understanding the Middle to Upper Paleolithic transition and the demise of the Neandertals, valuable evidence for these debates remains scarce and problematic in its interior regions. Sparse data supporting a late Neandertal persistence in the Iberian interior have been recently refuted and hence new evidence is needed to build new models on the timing and causes of Neandertal disappearance in inland Iberia and the whole peninsula...
2017: PloS One
https://www.readbyqxmd.com/read/28723772/anatomic-investigation-of-lumbar-transforaminal-fenestration-approach-and-its-clinical-application-in-far-lateral-disc-herniation
#4
Baoshan Xu, Haiwei Xu, Jean Destandau, Xinlong Ma, Jian He, Qun Xia, Ning Ji, Qiang Yang, Yue Liu, Hongfeng Jiang
Treating lumbar disease at the intervertebal foramina is controversial because we lack an approach providing sufficient exposure and preserving spinal stability. The primary objective of this study was to investigate the feasibility of the transforaminal fenestration (TFF) approach for treating lumbar disease involving the intervertebal foramina.In the anatomic study of 30 adult cadaveric lumbar spine specimens, the TFF approach was used from L1 to S1. The scope of resection was measured manually and on 3D CT images...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28722038/promises-facts-and-challenges-for-graphene-in-biomedical-applications
#5
Giacomo Reina, José Miguel González-Domínguez, Alejandro Criado, Ester Vázquez, Alberto Bianco, Maurizio Prato
The graphene family has captured the interest and the imagination of an increasing number of scientists working in different fields, ranging from composites to flexible electronics. In the area of biomedical applications, graphene is especially involved in drug delivery, biosensing and tissue engineering, with strong contributions to the whole nanomedicine area. Besides the interesting results obtained so far and the evident success, there are still many problems to solve, on the way to the manufacturing of biomedical devices, including the lack of standardization in the production of the graphene family members...
July 19, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28718836/the-biological-activities-of-sesterterpenoid-type-ophiobolins
#6
REVIEW
Wei Tian, Zixin Deng, Kui Hong
Ophiobolins (Ophs) are a group of tricarbocyclic sesterterpenoids whose structures contain a tricyclic 5-8-5 carbotricyclic skeleton. Thus far, 49 natural Ophs have been reported and assigned into A-W subgroups in order of discovery. While these sesterterpenoids were first characterized as highly effective phytotoxins, later investigations demonstrated that they display a broad spectrum of biological and pharmacological characteristics such as phytotoxic, antimicrobial, nematocidal, cytotoxic, anti-influenza and inflammation-promoting activities...
July 18, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28716262/new-genetic-causes-for-complex-hereditary-spastic-paraplegia
#7
Paulo Victor Sgobbi de Souza, Thiago Bortholin, Renan Braido Dias, Marco Antônio Troccoli Chieia, Stênio Burlin, Fernando George Monteiro Naylor, Wladimir Bocca Vieira de Rezende Pinto, Acary Souza Bulle Oliveira
INTRODUCTION: Hereditary Spastic Paraplegia (HSP) represents a complex and heterogeneous group of rare neurodegenerative disorders that share a common clinical feature of weakness and lower limb spasticity that can occur alone or in combination with a constellation of other neurological or systemic signs and symptoms. Although the core clinical feature of weakness and lower limb spasticity is virtually universal, the genetic heterogeneity is almost uncountable with more than 70 genetic forms described so far...
August 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28714565/mri-compatible-breast-rib-phantom-for-evaluating-ultrasonic-thermal-exposures
#8
Georgios Menikou, Marinos Yiannakou, Christos Yiallouras, Cleanthis Ioannides, Christakis Damianou
INTRODUCTION: The target of this study was the development of a magnetic resonance imaging (MRI) compatible breast phantom for focused ultrasound which includes plastic (ABS) ribs. The objective of the current study was the evaluation of a focused ultrasound procedure using the proposed phantom that eliminates rib heating. MATERIAL AND METHODS: The proposed phantom was evaluated using two different focused ultrasound exposures. The surrounding breast tissue was mimicked using an agar-silica-evaporation milk gel (2% w/v - 2% w/v - 40% v/v)...
July 17, 2017: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
https://www.readbyqxmd.com/read/28713695/robotic-modified-radical-neck-dissection-with-bilateral-axillo-breast-approach
#9
REVIEW
June Young Choi, Kyung Ho Kang
Bilateral axillo-breast approach (BABA) robotic thyroidectomy has been performed since 2008, and the indications of the BABA robotic operation has been widened to the robotic modified radical neck dissection (MRND). The indication for BABA robotic MRND is suspicious lateral neck metastasis of well-differentiated thyroid carcinoma, and the contraindication is far advanced carcinoma such as encasement of common carotid artery. Surgical procedures start from flap formation as a routine BABA robotic thyroidectomy and the lateral neck dissection is performed from level IV and Vb to level III and IIA...
June 2017: Gland Surgery
https://www.readbyqxmd.com/read/28712910/key-aspects-in-foramen-magnum-meningiomas-from-old-neuroanatomical-conceptions-to-current-far-lateral-neurosurgical-intervention
#10
REVIEW
Daniel S Leon-Ariza, Alvaro Campero, Rubby J Romero Chaparro, Diddier G Prada, Gabriel Vargas Grau, Albert L Rhoton
Foramen magnum meningiomas (FMM) represent a challenge for neurosurgeons. These tumors require careful surgical manipulation as they are often located in proximity to critical neurovascular structures and the cranial nerves. The far lateral approach is considered the safest neurosurgical approach for excising foramen magnum lesions. It facilitates the access to the anterior foramen magnum and reduces the retraction of vital structures. We describe key historical, epidemiological, genetic, epigenetic, clinical, and neurosurgical aspects of FMM...
July 13, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28711543/clival-defect-with-primary-csf-rhinorrhea-a-very-rare-presentation-with-challenging-management
#11
Sheikh Asad, Jens Peters-Willke, Warwick Brennan, Saima Asad
Primary spontaneous cerebrospinal fluid (CSF) rhinorrhea due to clival defect is an extremely rare presentation and only six cases have been reported in the literature so far(17). We present a unique case of a 64-year-old lady who presented with 2 years history of ongoing CSF rhinorrhea. She had similar episode at the age of 40 and suffered from meningitis. She had MRI, CT cisternogram as well as CT of brain and that showed clival defect with CSF leak into the sphenoid sinus. She underwent trans-sphenoidal repair of the clival defect with concurrent lumbar drain insertion for CSF drainage...
July 12, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28710509/x-shaped-inferior-extensor-retinaculum-and-its-doubtful-use-in-the-br%C3%A3-strom-gould-procedure
#12
M Dalmau-Pastor, F Malagelada, G M M J Kerkhoffs, M C Manzanares, J Vega
PURPOSE: The inferior extensor retinaculum (IER) is an aponeurotic structure located in the anterior aspect of the ankle. According to the literature, it can be used to reinforce a repair of the anterior talofibular ligament in ankle instability. Despite its usual description as an Y-shaped structure, it is still unclear which part of the retinaculum is used for this purpose, or if it is instead the crural fascia that is being used. The purpose of this study is to define the anatomical characteristics of the IER to better understand its role in the Broström-Gould procedure...
July 14, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28709999/tdcs-over-the-right-inferior-frontal-gyrus-disrupts-control-of-interference-in-memory-a-retrieval-induced-forgetting-study
#13
Davide F Stramaccia, Barbara Penolazzi, Gianmarco Altoè, Giovanni Galfano
Retrieving information from episodic memory may result in later inaccessibility of related but task-irrelevant information. This phenomenon, known as retrieval-induced forgetting, is thought to represent a specific instance of broader cognitive control mechanisms, that would come into play during memory retrieval, whenever non-target competing memories interfere with recall of target items. Recent neuroimaging studies have shown an association between these mechanisms and the activity of the right Prefrontal Cortex...
July 11, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28701396/effects-of-the-nedd8-activating-enzyme-inhibitor-mln4924-on-lytic-reactivation-of-kaposi-s-sarcoma-associated-herpesvirus
#14
Pey-Jium Chang, Lee-Wen Chen, Li-Yu Chen, Chien-Hui Hung, Ying-Ju Shih, Shie-Shan Wang
The switch of Kaposi's sarcoma-associated herpesvirus (KSHV) from latency to lytic replication is a key event for viral dissemination and pathogenesis. MLN4924, a novel neddylation inhibitor, reportedly causes the onset of KSHV reactivation but impairs later phases of viral lytic program in infected cells. Thus far, the molecular mechanism involved in the modulation of KSHV lytic cycle by MLN4924 is not yet fully understood. Here, we confirmed that treatment of different KSHV-infected primary effusion lymphoma (PEL) cell lines with MLN4924 substantially induces viral lytic protein expression...
July 12, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28696830/influence-of-temperature-on-the-efficacy-of-homologous-and-heterologous-dna-vaccines-against-viral-hemorrhagic-septicemia-in-pacific-herring
#15
Lucas M Hart, Niels Lorenzen, Katja Einer-Jensen, Maureen K Purcell, Paul K Hershberger
Homologous and heterologous (genogroup Ia) DNA vaccines against viral hemorrhagic septicemia virus (genogroup IVa) conferred partial protection in Pacific Herring Clupea pallasii. Early protection at 2 weeks postvaccination (PV) was low and occurred only at an elevated temperature (12.6°C, 189 degree days), where the relative percent survival following viral exposure was similar for the two vaccines (IVa and Ia) and higher than that of negative controls at the same temperature. Late protection at 10 weeks PV was induced by both vaccines but was higher with the homologous vaccine at both 9...
September 2017: Journal of Aquatic Animal Health
https://www.readbyqxmd.com/read/28694657/advances-in-surgical-management-for-locally-recurrent-rectal-cancer-how-far-have-we-come
#16
REVIEW
Daniel Jin-Keat Lee, Peter M Sagar, Gaitri Sadadcharam, Kok-Yang Tan
Locally recurrent rectal cancer (LRRC) is a complex disease with far-reaching implications for the patient. Until recently, research was limited regarding surgical techniques that can increase the ability to perform an en bloc resection with negative margins. This has changed in recent years and therefore outcomes for these patients have improved. Novel radical techniques and adjuncts allow for more radical resections thereby improving the chance of negative resection margins and outcomes. In the past contraindications to surgery included anterior involvement of the pubic bone, sacral invasions above the level of S2/S3 and lateral pelvic wall involvement...
June 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28692448/the-use-of-biosimilars-in-paediatric-inflammatory-bowel-disease
#17
Maria Myrthe Elisabeth Jongsma, Arnold Vulto, Lissy de Ridder
PURPOSE OF REVIEW: After expiry of the patent of originator anti-tumor necrosis factor drug infliximab (Remicade), CT-P13 was in 2013 the first infliximab biosimilar to be approved by the European Medicine Agency (EMA) for the same indications as the reference drug, including paediatric inflammatory bowel disease (IBD). The approval was based on extrapolation, after extensive in-vitro studies and clinical experience in patients with ankylosing spondylitis and rheumatoid arthritis. The extrapolation of CT-P13 to IBD and to paediatric patients raised concerns among paediatric IBD specialists...
July 7, 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/28691876/-physiological-pathophysiological-and-clinical-significance-of-chromogranins-secretogranins
#18
Lajos Jakab
This paper investigates the fundamental knowledge, build-up, as well as essential structural and important features of the big family of chromogranins/secretogranins. Previously the different properties and the slightly diverging funcional relations of the two family members were in focus. Later on, it has been discovered that they are essentially two similar compounds with identical structures and functions, and they are chemically, biochemically related. From details discovered so far we can tell that they are long polypeptid chains formed from amino acids...
July 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28690926/razanandrongobe-sakalavae-a-gigantic-mesoeucrocodylian-from-the-middle-jurassic-of-madagascar-is-the-oldest-known-notosuchian
#19
Cristiano Dal Sasso, Giovanni Pasini, Guillaume Fleury, Simone Maganuco
Razanandrongobe sakalavae Maganuco, Dal Sasso & Pasini, 2006 is a large predatory archosaur from the Middle Jurassic (Bathonian) of the Mahajanga Basin, NW Madagascar. It was diagnosed on the basis of teeth and a fragmentary maxilla, but its affinities were uncertain. Here we describe new cranial remains (above all, an almost complete right premaxilla and a caudally incomplete left dentary) that greatly improve our knowledge on this enigmatic species and reveal its anatomy to be crocodylomorph. The right premaxilla indicates that the rostrum was deep, wide, and not pointed; it bears five teeth that are sub-vertical and just slightly curved lingually; the mesial teeth are U-shaped in cross-section and have serrated carinae on the lingual side; the aperturae nasi osseae (external bony nares) are confluent and face rostrally; and there is no lateral groove at the premaxillomaxillary suture for reception of a hypertrophied lower caniniform tooth...
2017: PeerJ
https://www.readbyqxmd.com/read/28690110/mapping-load-bearing-in-the-mammalian-spindle-reveals-local-kinetochore-fiber-anchorage-that-provides-mechanical-isolation-and-redundancy
#20
Mary Williard Elting, Manu Prakash, Dylan B Udy, Sophie Dumont
Active forces generated at kinetochores move chromosomes, and the dynamic spindle must robustly anchor kinetochore fibers (k-fibers) to bear this load. The mammalian spindle bears the load of chromosome movement far from poles, but we do not know where and how-physically and molecularly-this load distributes across the spindle. In part, this is because probing spindle mechanics in live cells is difficult. Yet answering this question is key to understanding how the spindle generates and responds to force and performs its diverse mechanical functions...
June 29, 2017: Current Biology: CB
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