keyword
MENU ▼
Read by QxMD icon Read
search

Far lateral

keyword
https://www.readbyqxmd.com/read/29156084/role-of-charge-and-hydrophobicity-in-liprotide-formation-a-molecular-dynamics-study-with-experimental-constraints
#1
Jannik Nedergaard Pedersen, Pim Wilhelmus Johannes Maria Frederix, Jan Skov Pedersen, Siewert Jan Marrink, Daniel Otzen
Bovine α-lactalbumin (aLA) and oleate (OA) form a complex that has been intensively studied for its tumoricidal activity. Small-angle X-ray scattering (SAXS) has revealed a lipid core surrounded by partially unfolded protein. We call this type of complex a liprotide. Little is known of the molecular interactions between OA and aLA and no technique has so far provided any high resolution structure of liprotides. Here, we used coarse grained (CG) molecular dynamics (MD) simulations, Isothermal titration calorimetry (ITC) and SAXS to investigate the interactions between aLA and OA during the process of liprotide formation...
November 20, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29156047/immunopathogenesis-of-hepatitis-b-virus
#2
Tai-Chung Tseng, Li-Rung Huang
Chronic hepatitis B virus (HBV) infection is a global public health issue. There are >250 million people chronically infected with HBV, and these chronic carriers are at high risk of developing end-stage liver diseases and hepatocellular carcinoma. Patients with chronic hepatitis B (CHB) usually acquire the virus perinatally, while most patients infected during adulthood develop acute hepatitis B (AHB), which usually results in viral clearance. HBV infection is noncytopathic, and liver injury is mostly contributed by host immune responses...
November 16, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29152755/interviewing-intoxicated-witnesses-memory-performance-in-theory-and%C3%A2-practice
#3
Malin Hildebrand Karlén
Memory encoding and recall involving complex, effortful cognitive processes are impaired by alcohol primarily due to impairment of a select few, but crucial, cortical areas. This review shows how alcohol affects some, but not all, aspects of eyewitnesses' oral free recall performance. The principal results, so far, are that: a) free recall reports by intoxicated witnesses (at the investigated BAC-levels) may contain less, but as accurate, information as reports by sober witnesses; b) immediate reports given by intoxicated witnesses may yield more information compared to reports by sober witnesses given after a one week delay; c) an immediate interview may enhance both intoxicated and sober witnesses' ability to report information in a later interview; and d) reminiscence seems to occur over repeated interviews and the new information seems to be as accurate as the previously reported information...
November 20, 2017: Scandinavian Journal of Psychology
https://www.readbyqxmd.com/read/29151386/dysregulation-in-children-origins-and-implications-from-age-5-to-age-28
#4
Maureen E McQuillan, Ebru C Kultur, John E Bates, Lauren M O'Reilly, Kenneth A Dodge, Jennifer E Lansford, Gregory S Pettit
Research shows that childhood dysregulation is associated with later psychiatric disorders. It does not yet resolve discrepancies in the operationalization of dysregulation. It is also far from settled on the origins and implications of individual differences in dysregulation. This study tested several operational definitions of dysregulation using Achenbach attention, anxious/depressed, and aggression subscales. Individual growth curves of dysregulation were computed, and predictors of growth differences were considered...
November 20, 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/29150467/interventions-to-improve-adherence-to-reporting-guidelines-in-health-research-a-scoping-review-protocol
#5
David Blanco, Jamie J Kirkham, Douglas G Altman, David Moher, Isabelle Boutron, Erik Cobo
INTRODUCTION: There is evidence that the use of some reporting guidelines, such as the Consolidated Standards for Reporting Trials, is associated with improved completeness of reporting in health research. However, the current levels of adherence to reporting guidelines are suboptimal. Over the last few years, several actions aiming to improve compliance with reporting guidelines have been taken and proposed. We will conduct a scoping review of interventions to improve adherence to reporting guidelines in health research that have been evaluated or suggested, in order to inform future interventions...
November 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/29146377/cortical-processing-of-pitch-model-based-encoding-and-decoding-of-auditory-fmri-responses-to-real-life-sounds
#6
REVIEW
Vittoria De Angelis, Federico De Martino, Michelle Moerel, Roberta Santoro, Lars Hausfeld, Elia Formisano
Pitch is a perceptual attribute related to the fundamental frequency (or periodicity) of a sound. So far, the cortical processing of pitch has been investigated mostly using synthetic sounds. However, the complex harmonic structure of natural sounds may require different mechanisms for the extraction and analysis of pitch. This study investigated the neural representation of pitch in human auditory cortex using model-based encoding and decoding analyses of high field (7 T) functional magnetic resonance imaging (fMRI) data collected while participants listened to a wide range of real-life sounds...
November 13, 2017: NeuroImage
https://www.readbyqxmd.com/read/29144145/a-social-comparison-theory-meta-analysis-60-years-on
#7
J P Gerber, Ladd Wheeler, Jerry Suls
These meta-analyses of 60+ years of social comparison research focused on 2 issues: the choice of a comparison target (selection) and the effects of comparisons on self-evaluations, affect, and so forth (reaction). Selection studies offering 2 options (up or down) showed a strong preference (and no evidence of publication bias) for upward choices when there was no threat; there was no evidence for downward comparison as a dominant choice even when threatened. Selections became less differentiable when a lateral choice was also provided...
November 16, 2017: Psychological Bulletin
https://www.readbyqxmd.com/read/29143842/wrinkling-formation-in-simply-supported-graphenes-under-tension-and-compression-loadings
#8
Ch Androulidakis, E N Koukaras, M G Pastore Carbone, M Hadjinicolaou, C Galiotis
Wrinkles in supported graphenes can be formed either by uniaxial compression or uniaxial tension beyond a certain critical load depending on the mode of loading. In the first case, the wrinkling direction is normal to the compression axis whereas in tension, wrinkles of the same pattern are formed parallel to the loading direction due to Poisson's (lateral) contraction. Herein we show by direct AFM observations that in simply-supported graphenes such instabilities appear as periodic wrinkles over existing stochastic undulations caused by the underlying-substrate-roughness...
November 16, 2017: Nanoscale
https://www.readbyqxmd.com/read/29143574/investigating-the-preventive-effects-of-baicalin-and-gallocatechin-aginst-glyoxal-induced-cystatin-aggregation
#9
Aamir Sohail, Waseem Feeroze Bhat, Mohammad Furkan, Aaliya Shah, Bilqees Bano
Several mammalian proteins form pathological deposits under nonphysiological conditions that are associated with many degenerative diseases. Protein aggregation is associated with aging, as well as a variety of diseases, including cystic fibrosis, amyotrophic lateral sclerosis (ALS), and hypertrophic cardiomyopathy. There is a lack of any potential anti-amyloidogenic agents and therapeutics till date. Polyphenols have been accredited with myriad biological effects. An analysis of the effects of natural agents like baicalin (BC) and gallocatechin (GC) on aggregation process can open new avenues for the treatment of protein misfolding diseases...
November 16, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29142104/constraints-on-lateral-gene-transfer-in-promoting-fimbrial-usher-protein-diversity-and-function
#10
Christopher J Stubenrauch, Gordon Dougan, Trevor Lithgow, Eva Heinz
Fimbriae are long, adhesive structures widespread throughout members of the family Enterobacteriaceae. They are multimeric extrusions, which are moved out of the bacterial cell through an integral outer membrane protein called usher. The complex folding mechanics of the usher protein were recently revealed to be catalysed by the membrane-embedded translocation and assembly module (TAM). Here, we examine the diversity of usher proteins across a wide range of extraintestinal (ExPEC) and enteropathogenic (EPEC) Escherichia coli, and further focus on a so far undescribed chaperone-usher system, with this usher referred to as UshC...
November 2017: Open Biology
https://www.readbyqxmd.com/read/29141179/formation-of-longitudinal-axon-pathways-in-caenorhabditis-elegans
#11
REVIEW
Harald Hutter
The small number of neurons and the simple architecture of the Caenorhabditis elegans (C. elegans) nervous system enables researchers to study axonal pathfinding at the level of individually identified axons. Axons in C. elegans extend predominantly along one of the two major body axes, the anterior-posterior axis and the dorso-ventral axis. This review will focus on axon navigation along the anterior-posterior axis, leading to the establishment of the longitudinal axon tracts, with a focus on the largest longitudinal axon tract, the ventral nerve cord (VNC)...
November 12, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29141048/microcirculation-in-open-vs-minimally-invasive-dorsal-stabilization-of-thoracolumbar-fractures
#12
Bergita Ganse, Miguel Pishnamaz, Philipp Kobbe, Christian Herren, Gertraud Gradl-Dietsch, Franziska Böhle, Bernd Johannes, Bong-Sung Kim, Klemens Horst, Matthias Knobe
Standard open and percutaneous minimally invasive surgical procedures co-exist in the treatment of fractures of the thoracolumbar spine. Shorter skin incisions just above the pedicles are used in minimally invasive procedures. Full-length skin incisions and invasive preparations are applied in the standard open approach. While both methods show equivalent rates of intraoperative surgical complications and comparable clinical and radiological outcomes, blood loss and operation time have shown to be decreased in minimally invasive treatment...
2017: PloS One
https://www.readbyqxmd.com/read/29140716/transversely-divergent-second-harmonic-generation-by-surface-plasmon-polaritons-on-single-metallic-nanowires
#13
Yang Li, Meng Kang, Junjun Shi, Ke Wu, Shunping Zhang, Hongxing Xu
Coherently adding up signal wave from different locations are a prerequisite for realizing efficient nonlinear optical processes in traditional optical configurations. While nonlinear optical processes in plasmonic waveguides with subwavelength light confinement are in principle desirable for enhancing nonlinear effects, so far it has been difficult to improve the efficiency due to the large momentum mismatch. Here we demonstrate, using remotely excited surface plasmon polaritons (SPPs), axial collimated but transversely divengent second harmonic (SH) generation in a single silver nanowire - monolayer molybdenum disulfide hybrid system...
November 15, 2017: Nano Letters
https://www.readbyqxmd.com/read/29139625/late-graft-failure-after-kidney-transplantation-as-the-consequence-of-late-versus-early-events
#14
Robert S Gaston, Ann Fieberg, Lawrence Hunsicker, Bertram L Kasiske, Robert Leduc, Fernando G Cosio, Sita Gourishankar, Joseph Grande, Roslyn B Mannon, David Rush, Michael J Cecka, John Connett, Arthur J Matas
Beyond the first posttransplant year, 3% of kidney transplants fail annually. In a prospective, multicenter cohort study, we tested the relative impact of early versus late events on risk of long-term death-censored graft failure (DCGF). In grafts surviving at least 90 days, early events (acute rejection [AR] and delayed graft function [DGF] before day 90) were recorded; serum creatinine (Cr) at day 90 was defined as baseline. Thereafter, a 25% rise in serum Cr or new onset proteinuria triggered graft biopsy (index biopsy, IBx), allowing comparison of risk of DCGF associated with early events (AR, DGF, baseline serum Cr >2...
November 15, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/29132797/cloaca-reconstruction-a-new-algorithm-which-considers-the-role-of-urethral-length-in-determining-surgical-planning
#15
Richard J Wood, Carlos A Reck-Burneo, Daniel Dajusta, Christina Ching, Rama Jayanthi, D Gregory Bates, Molly E Fuchs, Katherine McCracken, Geri Hewitt, Marc A Levitt
BACKGROUND: Cloacal malformations represent a uniquely complex challenge for surgeons. The surgical approach to date has been based on the common channel (CC) length with two patient groups considered: less than or greater than 3cm, which we believe is an oversimplification. We reviewed 19 patients, referred after surgery done elsewhere. Eight had postoperative urinary complications, 3 had constant urinary leakage and had been left after surgery with a urethra <1cm, .5 with an original 3 to 5cm common channel, who had undergone total urogenital mobilization (TUM), experienced peri-operative urethral loss needing a vesicostomy, and later, a Mitrofanoff...
October 12, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29128954/surgical-approach-to-posterior-inferior-cerebellar-artery-aneurysms
#16
Biagia La Pira, Carmelo Lucio Sturiale, Giuseppe Maria Della Pepa, Alessio Albanese
BACKGROUND: The far-lateral is a standardised approach to clip aneurysms of the posterior inferior cerebellar artery (PICA). Different variants can be adopted to manage aneurysms that differ in morphology, topography, ruptured status, cerebellar swelling and surgeon preference. METHOD: We distinguished five paradigmatic approaches aimed to manage aneurysms that are: proximal unruptured; proximal ruptured requiring posterior fossa decompression (PFD); proximal ruptured not requiring PFD; distal unruptured; distal ruptured...
November 11, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29127470/rectus-abdominis-muscle-innervation-an-anatomical-study-with-surgical-implications-in-diep-flap-harvesting
#17
Carla Stecco, Gian Paolo Azzena, Veronica Macchi, Andrea Porzionato, Astrid Behr, Anna Rambaldo, Cesare Tiengo, Raffaele De Caro
PURPOSE: To improve the current knowledge of rectus abdominis innervation, so as to identify a safe area where the vascular pedicle should be dissected to reduce the risk of nerve damage during deep inferior epigastric perforator (DIEP) flap harvesting. METHODS: Ten abdominal wall dissections were performed. Perforating arteries were identified and classified into nerve-related perforators and non-nerve-related perforators depending on the presence of nerve branches crossing vessels...
November 10, 2017: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/29127025/effect-of-yolk-corticosterone-on-begging-in-the-yellow-legged-gull
#18
Cristina Daniela Possenti, Marco Parolini, Andrea Romano, Manuela Caprioli, Diego Rubolini, Nicola Saino
Behavioral lateralization is widespread across vertebrates. The development of lateralization is affected by both genetic and environmental factors. In birds, maternal substances in the egg can affect offspring lateralization via activational and/or organizational effects. Corticosterone affects the development of brain asymmetry, suggesting that variation in yolk corticosterone concentration may also influence post-natal behavioral lateralization, a hypothesis that has never been tested so far. In the yellow-legged gull (Larus michahellis), we increased yolk corticosterone concentration within physiological limits and analyzed the direction of lateralization of hatchlings in reverting from supine to prone position ('RTP' response) and in pecking at dummy parental bills to solicit food provisioning ('begging' response)...
November 15, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/29122694/pharmacotherapy-for-nash-current-and-emerging
#19
REVIEW
Monica A Konerman, Jacob C Jones, Stephen A Harrison
Non-alcoholic fatty liver disease (NAFLD) has become one of the most prominent forms of chronic liver disease worldwide, reflecting the epidemic of global obesity. Those with the progressive variant of NAFLD, non-alcoholic steatohepatitis (NASH), are at significantly increased risk of multisystem morbidity and mortality. However, there are currently no approved pharmacologic therapies for NASH. Given the disease burden, there is an important unmet need for pharmacologic treatment options for this patient population...
November 6, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/29115927/transcriptomic-responses-to-wounding-meta-analysis-of-gene-expression-microarray-data
#20
Piotr Andrzej Sass, Michał Dąbrowski, Agata Charzyńska, Paweł Sachadyn
BACKGROUND: A vast amount of microarray data on transcriptomic response to injury has been collected so far. We designed the analysis in order to identify the genes displaying significant changes in expression after wounding in different organisms and tissues. This meta-analysis is the first study to compare gene expression profiles in response to wounding in as different tissues as heart, liver, skin, bones, and spinal cord, and species, including rat, mouse and human. RESULTS: We collected available microarray transcriptomic profiles obtained from different tissue injury experiments and selected the genes showing a minimum twofold change in expression in response to wounding in prevailing number of experiments for each of five wound healing stages we distinguished: haemostasis & early inflammation, inflammation, early repair, late repair and remodelling...
November 7, 2017: BMC Genomics
keyword
keyword
73149
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"