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https://www.readbyqxmd.com/read/28817154/the-gold-nun-a-case-of-a-gold-ligature-from-the-15-th-century-and-the-origins-of-restorative-dentistry-in-europe
#1
Eugénia Cunha, Catarina Leal, Miguel Munhós, Isabel Poiares Baptista
We here report the discovery of a gold dental ligature from the late 15(th) century, at the Convent of Santa Clara-a-Velha, in the city of Coimbra, Portugal. A medieval Clare's nun presented the left upper lateral incisor splinted to the canine, since the others three incisors were lost, most probably due to an aggressive periodontal disease. The convent is associated with the medieval upper class, which was well known for its consumption of high levels of sugar. There is a higher prevalence of caries in comparison to other Portuguese skeletal samples of the same time period, as well as a high prevalence of periodontal disease...
August 17, 2017: Anthropologischer Anzeiger; Bericht über die Biologisch-anthropologische Literatur
https://www.readbyqxmd.com/read/28814374/from-bench-laboratory-to-bed-hospital-home-how-to-explore-effective-natural-and-synthetic-pak1-blockers-longevity-promoters-for-cancer-therapy
#2
REVIEW
Hiroshi Maruta, Mok-Ryeon Ahn
PAK family kinases are RAC/CDC42-activated kinases that were first found in a soil amoeba 4 decades ago, and 2 decades later, were discovered in mammals as well. Since then at least 6 members of this family have been identified in mammals. One of them called PAK1 has been best studied so far, mainly because it is essential not only for malignant cell growth and metastasis, but also for many other diseases/disorders such as diabetes (type 2), AD (Alzheimer's disease), hypertension, and a variety of inflammatory or infectious diseases, which definitely shorten our lifespan...
August 9, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28808602/high-lumbar-noninstrumented-fusion-rates-using-lamina-autograft-and-nanoss-bone-marrow-aspirate
#3
Nancy E Epstein
BACKGROUND: Patients with marked osteoporosis and/or obesity/morbid obesity and severe multilevel lumbar stenosis and other pathology often undergo multilevel laminectomies with non instrumented posterolateral fusions (PLF). The other pathology may include combinations of degenerative spondylolisthesis/lysis, foraminal/far lateral discs, and/or synovial cysts requiring more extensive facet resections. Presently, spine surgeons often use bone graft expanders to supplement the lamina autograft harvested in the course of laminectomy/decompressions for the PLF mass...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28808567/community-based-saving-groups-an-innovative-approach-to-overcome-the-financial-and-social-barriers-in-health-care-seeking-by-the-women-in-the-rural-remote-communities-of-pakistan
#4
Babar Tasneem Shaikh, Qayyum Noorani, Shazia Abbas
BACKGROUND: In remote rural areas of Pakistan, access to the maternal, newborn and child health (MNCH) care provided by a skilled health provider is quite difficult. There are many reasons such as women's restricted social mobility, lack of education, disenfranchised in decision making and poverty. To overcome these barriers and impediments in district Chitral, which is the largest territory in terms of geography in province Khyber Pakhtunkhwa, local women of reproductive age, were mobilized to form the Community Based Saving Groups (CBSGs) at the village level...
2017: Archives of Public Health, Archives Belges de Santé Publique
https://www.readbyqxmd.com/read/28800923/-squamous-cell-carcinoma-associated-with-use-of-skin-lightening-cream
#5
O Faye, A-A Dicko, S Berthé, L Cissé, B Traoré, A Keita, Y Fofana, K Coulibaly, B Keita
BACKGROUND: Women widely use skin-lightening products for cosmetic purposes in sub-Saharan Africa despite numerous reported cutaneous and systemic complications. The occurrence of epidermoid carcinoma has long been reported, but only three cases have been published so far. We report the first case in Mali. PATIENTS AND METHODS: A 30-year old woman with no noteworthy medical history was seen at our outpatient center for cervical ulceration that had been present for the last 5 years...
August 8, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/28798129/changing-climate-shifts-timing-of-european-floods
#6
Günter Blöschl, Julia Hall, Juraj Parajka, Rui A P Perdigão, Bruno Merz, Berit Arheimer, Giuseppe T Aronica, Ardian Bilibashi, Ognjen Bonacci, Marco Borga, Ivan Čanjevac, Attilio Castellarin, Giovanni B Chirico, Pierluigi Claps, Károly Fiala, Natalia Frolova, Liudmyla Gorbachova, Ali Gül, Jamie Hannaford, Shaun Harrigan, Maria Kireeva, Andrea Kiss, Thomas R Kjeldsen, Silvia Kohnová, Jarkko J Koskela, Ondrej Ledvinka, Neil Macdonald, Maria Mavrova-Guirguinova, Luis Mediero, Ralf Merz, Peter Molnar, Alberto Montanari, Conor Murphy, Marzena Osuch, Valeryia Ovcharuk, Ivan Radevski, Magdalena Rogger, José L Salinas, Eric Sauquet, Mojca Šraj, Jan Szolgay, Alberto Viglione, Elena Volpi, Donna Wilson, Klodian Zaimi, Nenad Živković
A warming climate is expected to have an impact on the magnitude and timing of river floods; however, no consistent large-scale climate change signal in observed flood magnitudes has been identified so far. We analyzed the timing of river floods in Europe over the past five decades, using a pan-European database from 4262 observational hydrometric stations, and found clear patterns of change in flood timing. Warmer temperatures have led to earlier spring snowmelt floods throughout northeastern Europe; delayed winter storms associated with polar warming have led to later winter floods around the North Sea and some sectors of the Mediterranean coast; and earlier soil moisture maxima have led to earlier winter floods in western Europe...
August 11, 2017: Science
https://www.readbyqxmd.com/read/28796730/squamous-cancers-of-the-rectum-demonstrate-poorer-survival-and-increased-need-for-salvage-surgery-compared-with-squamous-cancers-of-the-anus
#7
Audrey S Kulaylat, Christopher S Hollenbeak, David B Stewart
BACKGROUND: Squamous cell cancers of the anus are rare GI malignancies for which neoadjuvant chemoradiation is the first-line treatment for nonmetastatic disease. Squamous cancers of the rectum are far less common, and it is unclear to what degree chemoradiotherapy improves their outcomes. OBJECTIVE: The purpose of this study was to compare stage-specific survival for anal and rectal squamous cancers stratified by treatment approach. DESIGN: This was a retrospective cohort study...
September 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28795614/shifting-borders-crossing-boundaries-the-case-of-combined-central-and-peripheral-demyelination
#8
Orhan Aktas
The case report by Puthenparampil et al. suggests that heterogeneity of demyelinating diseases may be more complex than expected. The authors describe a female patient starting with isolated but relapsing myelitis (in the absence of oligoclonal bands or anti-aquaporin 4 antibodies) and later experiencing the simultaneous occurrence of inflammatory demyelinating polyneuropathy and of a tumefactive hippocampal brain lesion responsive to immunotherapy. As testing for antibodies against established and novel auto-antigens including neurofascin-155 was negative, this case may be regarded as an example for the unfolding spectrum of combined central and peripheral demyelination (CCPD) syndromes with so far unknown immunological target(s)...
August 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28792504/common-gene-network-signature-of-different-neurological-disorders-and-their-potential-implications-to-neuroaids
#9
Vidya Sagar, S Pilakka-Kanthikeel, Paola C Martinez, V S R Atluri, M Nair
The neurological complications of AIDS (neuroAIDS) during the infection of human immunodeficiency virus (HIV) are symptomized by non-specific, multifaceted neurological conditions and therefore, defining a specific diagnosis/treatment mechanism(s) for this neuro-complexity at the molecular level remains elusive. Using an in silico based integrated gene network analysis we discovered that HIV infection shares convergent gene networks with each of twelve neurological disorders selected in this study. Importantly, a common gene network was identified among HIV infection, Alzheimer's disease, Parkinson's disease, multiple sclerosis, and age macular degeneration...
2017: PloS One
https://www.readbyqxmd.com/read/28791286/autoimmune-thrombotic-thrombocytopenic-purpura-two-rare-cases-associated-with-juvenile-idiopathic-arthritis-and-multiple-sclerosis
#10
Despoina Dimopoulou, Athina Dimosiari, Eudokia Mandala, Theodoros Dimitroulas, Alaxandros Garyfallos
Secondary thrombotic microangiopathies are associated with several underlying conditions, with most of them being resolved after the treatment of background disease. Thrombotic thrombocytopenic purpura (TTP) is a rare microangiopathy presenting with anemia, thrombocytopenia, and neurological deficits, occurring most often in various autoimmune diseases due to inhibition of ADAMTS13 by autoantibodies, as well as in pregnant women with or without an autoimmune substrate. In this article, we report two newly diagnosed TTP cases, who have not been published so far...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28791194/a-case-report-of-surgical-management-of-hemangiopericytoma-at-the-foramen-magnum
#11
Nobuhiko Arai, Satoshi Takahashi, Hatano Mami, Yukina Tokuda, Kazunari Yoshida
BACKGROUND: Hemangiopericytoma (HPC) is a highly vascularized mesenchymal tumor known for its high rates of recurrence and metastasis. The extent of tumor removal is known to be the most trustful prognostic factor. Skull base HPCs are challenging to treat because of the difficulty of the surgical approach and proximity to vital vascular and neuronal structures. We successfully treated a case of HPC at the ventral foramen magnum through surgical gross tumor removal via a far-lateral transcondylar approach...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28790465/surgical-approaches-for-total-hip-arthroplasty
#12
Vincent M Moretti, Zachary D Post
Total hip arthroplasty (THA) has become one of the most reliable and patient-requested surgical interventions in all medicine. The procedure can be performed using a variety of surgical approaches, but the posterior approach, direct lateral approach, and direct anterior approach are by far the most common across the globe. This article highlights the history and technique for each of these common approaches. A review of outcomes and complications for each approach are also provided. Each approach has its own unique advantages and disadvantages, but all can be safely and successful utilized for THA...
July 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/28789939/bioremediation-3-0-engineering-pollutant-removing-bacteria-in-the-times-of-systemic-biology
#13
REVIEW
Pavel Dvořák, Pablo I Nikel, Jiří Damborský, Víctor de Lorenzo
Elimination or mitigation of the toxic effects of chemical waste released to the environment by industrial and urban activities relies largely on the catalytic activities of microorganisms-specifically bacteria. Given their capacity to evolve rapidly, they have the biochemical power to tackle a large number of molecules mobilized from their geological repositories through human action (e.g., hydrocarbons, heavy metals) or generated through chemical synthesis (e.g., xenobiotic compounds). Whereas naturally occurring microbes already have considerable ability to remove many environmental pollutants with no external intervention, the onset of genetic engineering in the 1980s allowed the possibility of rational design of bacteria to catabolize specific compounds, which could eventually be released into the environment as bioremediation agents...
August 5, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/28783259/anticipating-cutoff-diameters-in-deterministic-lateral-displacement-dld-microfluidic-devices-for-an-optimized-particle-separation
#14
Eloise Pariset, Catherine Pudda, François Boizot, Nicolas Verplanck, Jean Berthier, Aurélie Thuaire, Vincent Agache
Deterministic lateral displacement (DLD) devices enable to separate nanometer to micrometer-sized particles around a cutoff diameter, during their transport through a microfluidic channel with slanted rows of pillars. In order to design appropriate DLD geometries for specific separation sizes, robust models are required to anticipate the value of the cutoff diameter. So far, the proposed models result in a single cutoff diameter for a given DLD geometry. This paper shows that the cutoff diameter actually varies along the DLD channel, especially in narrow pillar arrays...
August 7, 2017: Small
https://www.readbyqxmd.com/read/28782686/stem-cells-in-cardiovascular-diseases-turning-bad-days-into-good-ones
#15
REVIEW
Maira Souza de Oliveira, Felipe Saldanha-Araujo, Alfredo Miranda de Goes, Fabricio F Costa, Juliana Lott de Carvalho
During the past decade, several types of stem cells have been investigated as promising therapeutic agents for cardiovascular diseases (CVDs). Among them, mesenchymal stem cells (MSCs) were the most investigated stem cell population. Hundreds of clinical trials later, results remain disappointing and far from the revolutionary improvements expected for heart function. In the present review, we address strategies under investigation to boost MSC therapy for CVDs. Pluripotent stem cells (PSCs) are also intended to reach clinical applications for CVDs, but here we suggest that, in the short term, the major impact of PSCs in the cardiovascular field might be at the bench and not the bedside...
August 4, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/28780963/effect-of-contact-angle-and-contact-angle-hysteresis-on-the-floatability-of-spheres-at-the-air-water-interface
#16
REVIEW
Dong-Xia Feng, Anh V Nguyen
The floatability of solid particles on the water surface governs many natural phenomena and industrial processes including film flotation and froth flotation separation of coal and valuable minerals. For many years, the contact angle (CA) has been postulated as the key factor in determining the particle floatability. Indeed, the maximum force (tenacity) supporting the flotation of fine spheres was conjectured to occur when the apical angle of the contact circle is equal to the contact angle. In this paper, the model predictions are reviewed and compared with experimental results...
July 28, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28777824/shaping-visual-space-perception-through-bodily-sensations-testing-the-impact-of-nociceptive-stimuli-on-visual-perception-in-peripersonal-space-with-temporal-order-judgments
#17
Lieve Filbrich, Andrea Alamia, Séverine Blandiaux, Soline Burns, Valéry Legrain
Coordinating spatial perception between body space and its external surrounding space is essential to adapt behaviors to objects, especially when they are noxious. Such coherent multisensory representation of the body extended into external space is conceptualized by the notion of peripersonal reference frame, mapping the portion of space in which somatic and extra-somatic inputs interact closely. Studies on crossmodal interactions between nociception and vision have been scarce. Here we investigated how the perception of visual stimuli, especially those surrounding the body, can be impacted by a nociceptive and potentially harmful stimulus inflicted on a particular body part...
2017: PloS One
https://www.readbyqxmd.com/read/28772168/prevalence-and-seasonality-of-six-respiratory-viruses-during-five-consecutive-epidemic-seasons-in-belgium
#18
Kaat Ramaekers, Els Keyaerts, Annabel Rector, Annie Borremans, Kurt Beuselinck, Katrien Lagrou, Marc Van Ranst
BACKGROUND: Acute Respiratory Infections (ARIs) are a major health problem, especially in young children and the elderly. OBJECTIVES: Insights into the seasonality of respiratory viruses can help us understand when the burden on society is highest and which age groups are most vulnerable. STUDY DESIGN: We monitored six respiratory viruses during five consecutive seasons (2011-2016) in Belgium. Patient specimens (n=22876), tested for one or more of the following respiratory viruses, were included in this analysis: Influenza viruses (IAV & IBV), Human respiratory syncytial virus (hRSV), Human metapneumovirus (hMPV), Adenovirus (ADV) and Human parainfluenza virus (hPIV)...
July 23, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28769918/high-tolerance-of-hydrogenothermus-marinus-to-sodium-perchlorate
#19
Kristina Beblo-Vranesevic, Harald Huber, Petra Rettberg
On Mars, significant amounts (0.4-0.6%) of perchlorate ions were detected in dry soil by the Phoenix Wet Chemistry Laboratory and later confirmed with the Mars Science Laboratory. Therefore, the ability of Hydrogenothermus marinus, a desiccation tolerant bacterium, to survive and grow in the presence of perchlorates was determined. Results indicated that H. marinus was able to tolerate concentrations of sodium perchlorate up to 200 mM ( 1.6%) during cultivation without any changes in its growth pattern. After the addition of up to 440 mM ( 3...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28769751/neuronal-correlates-of-individual-differences-in-the-big-five-personality-traits-evidences-from-cortical-morphology-and-functional-homogeneity
#20
Ting Li, Xu Yan, Yuan Li, Junjie Wang, Qiang Li, Hong Li, Junfeng Li
There have been many neuroimaging studies of human personality traits, and it have already provided glimpse into the neurobiology of complex traits. And most of previous studies adopt voxel-based morphology (VBM) analysis to explore the brain-personality mechanism from two levels (vertex and regional based), the findings are mixed with great inconsistencies and the brain-personality relations are far from a full understanding. Here, we used a new method of surface-based morphology (SBM) analysis, which provides better alignment of cortical landmarks to generate about the associations between cortical morphology and the personality traits across 120 healthy individuals at both vertex and regional levels...
2017: Frontiers in Neuroscience
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