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https://www.readbyqxmd.com/read/29341898/induction-of-alpha-synuclein-pathology-in-the-enteric-nervous-system-of-the-rat-and-non-human-primate-results-in-gastrointestinal-dysmotility-and-transient-cns-pathology
#1
Fredric P Manfredsson, Kelvin C Luk, Matthew J Benskey, Aysegul Guezer, Joanna Garcia, Nathan C Kuhn, Ivette M Sandoval, Joseph R Patterson, Alana O'Mara, Reid Yonkers, Jeffrey H Kordower
Alpha-Synuclein (α-syn) is by far the most highly vetted pathogenic and therapeutic target in Parkinson's disease. Aggregated α-syn is present in sporadic Parkinson's disease, both in the central nervous system (CNS) and peripheral nervous system (PNS). The enteric division of the PNS is of particular interest because 1) gastric dysfunction is a key clinical manifestation of Parkinson's disease, and 2) Lewy pathology in myenteric and submucosal neurons of the enteric nervous system (ENS) has been referred to as stage zero in the Braak pathological staging of Parkinson's disease...
January 13, 2018: Neurobiology of Disease
https://www.readbyqxmd.com/read/29340757/comparing-brain-activity-patterns-during-spontaneous-exploratory-and-cue-instructed-learning-using-single-photon-emission-computed-tomography-spect-imaging-of-regional-cerebral-blood-flow-in-freely-behaving-rats
#2
A Mannewitz, J Bock, S Kreitz, A Hess, J Goldschmidt, H Scheich, Katharina Braun
Learning can be categorized into cue-instructed and spontaneous learning types; however, so far, there is no detailed comparative analysis of specific brain pathways involved in these learning types. The aim of this study was to compare brain activity patterns during these learning tasks using the in vivo imaging technique of single photon-emission computed tomography (SPECT) of regional cerebral blood flow (rCBF). During spontaneous exploratory learning, higher levels of rCBF compared to cue-instructed learning were observed in motor control regions, including specific subregions of the motor cortex and the striatum, as well as in regions of sensory pathways including olfactory, somatosensory, and visual modalities...
January 16, 2018: Brain Structure & Function
https://www.readbyqxmd.com/read/29339489/rogue-waves-and-large-deviations-in-deep-sea
#3
Giovanni Dematteis, Tobias Grafke, Eric Vanden-Eijnden
The appearance of rogue waves in deep sea is investigated by using the modified nonlinear Schrödinger (MNLS) equation in one spatial dimension with random initial conditions that are assumed to be normally distributed, with a spectrum approximating realistic conditions of a unidirectional sea state. It is shown that one can use the incomplete information contained in this spectrum as prior and supplement this information with the MNLS dynamics to reliably estimate the probability distribution of the sea surface elevation far in the tail at later times...
January 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29338427/lipid-nanoparticles-for-intranasal-administration-application-to-nose-to-brain-delivery
#4
Luigi Battaglia, Pier Paolo Panciani, Elisabetta Muntoni, Maria Teresa Capucchio, Elena Biasibetti, Pasquale De Bonis, Silvia Mioletti, Marco Fontanella, Shankar Swaminathan
The blood brain barrier is a functional barrier allowing the entry into the brain of only essential nutrients, excluding other molecules. Its structure, although essential to keep the harmful entities out, is also a major roadblock for pharmacological treatment of brain diseases. Several alternative invasive drug delivery approaches, such as transcranial drug delivery and disruption of blood brain barrier have been explored, with limited success and several challenges. Intranasal delivery is a non-invasive methodology, which bypasses the systemic circulation, and, through the intra- and extra- neuronal pathways, provides direct brain drug delivery...
January 17, 2018: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/29338310/therapy-induced-plasticity-in-chronic-aphasia-is-associated-with-behavioral-improvement-and-time-since-stroke
#5
Priya Santhanam, E Susan Duncan, Steven L Small
Cortical reorganization after stroke is thought to underlie functional improvement. Patterns of reorganization may differ depending on the amount of time since the stroke or the degree of improvement. We investigated these issues in a study of brain connectivity changes with aphasia therapy. Twelve individuals with chronic aphasia participated in a 6-week trial of imitation-based speech therapy. We assessed improvement on a repetition test and analyzed effective connectivity during functional magnetic resonance imaging (fMRI) of a speech observation task before and after therapy...
January 16, 2018: Brain Connectivity
https://www.readbyqxmd.com/read/29337012/expanding-the-limits-of-endoscopic-intraorbital-tumor-resection-using-3-dimensional-reconstruction
#6
Luciano Lobato Gregorio, Nicolas Y Busaba, Marcel M Miyake, Suzanne K Freitag, Benjamin S Bleier
INTRODUCTION: Endoscopic orbital surgery is a nascent field and new tools are required to assist with surgical planning and to ascertain the limits of the tumor resectability. OBJECTIVE: We purpose to utilize three-dimensional radiographic reconstruction to define the theoretical lateral limit of endoscopic resectability of primary orbital tumors and to apply these boundary conditions to surgical cases. METHODS: A three-dimensional orbital model was rendered in 4 representative patients presenting with primary orbital tumors using OsiriX open source imaging software...
December 26, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/29335673/desistance-and-severity-of-alcohol-use-disorder-a-lifespan-developmental-investigation
#7
Matthew R Lee, Cassandra L Boness, Yoanna E McDowell, Alvaro Vergés, Douglas L Steinley, Kenneth J Sher
Key to an understanding of alcohol use disorder (AUD) are the drinking-related reductions that begin in young adulthood and continue throughout the adult lifespan. Research is needed to precisely characterize the form of these reductions, including possible developmental differences across the lifespan. Using U.S.-representative data, we estimated multiple-group Markov models characterizing longitudinal transitions among five drinking statuses and differences in transition patterns across six adult age periods...
2018: Clinical Psychological Science
https://www.readbyqxmd.com/read/29330019/parental-decisional-regret-and-views-about-optimal-timing-of-female-genital-restoration-surgery-in-congenital-adrenal-hyperplasia
#8
Konrad M Szymanski, Benjamin Whittam, Martin Kaefer, Heather Frady, Jessica T Casey, Vi T Tran, Mark P Cain, Richard C Rink
PURPOSE: The role of female genital restoration surgery (FGRS) in girls with congenital adrenal hyperplasia (CAH) is controversial, with no long-term parent-reported outcomes available. Decisional regret (DR) affects most parents after their children's treatment of pediatric conditions, including hypospadias. We aimed to assess parental DR after FGRS in infancy or toddlerhood and explore optimal timing for surgery. MATERIALS AND METHODS: One-hundred and six parents of females with CAH undergoing FGRS before 3 years old and followed at our institution (1999-2017) were invited to enroll online...
December 28, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29326776/aorto-right-ventricular-fistula-following-percutaneous-transcatheter-aortic-valve-replacement-case-report-and-literature-review
#9
Monoj K Konda, Jagadeesh K Kalavakunta, Jerry W Pratt, David Martin, Vishal Gupta
An 88-year-old woman with a prior history of aortic stenosis and history of valvuloplasty presented with worsening symptoms of heart failure and dizziness. She underwent successful transcatheter aortic valve replacement (TAVR) without complications. Follow-up echocardiograms revealed a small fistula connecting aorta to the right ventricle. The patient was initially asymptomatic but 3 months later developed overload of the right ventricle and heart failure and chose to continue medical therapy. She died of progressive heart failure at 9 months from onset of fistula...
October 2017: Heart Views: the Official Journal of the Gulf Heart Association
https://www.readbyqxmd.com/read/29325938/aortic-coarctation-complicated-with-intracranial-aneurysm-a-case-report-and-literature-review
#10
Hui Zhang, Lei Feng
BACKGROUND: Cases of aortic coarctation complicated with rupture and hemorrhage of intracranial aneurysms are not common in clinical practice. This paper reports a case of middle-aged female patient presented with acute severe headache. CASE DESCRIPTION: Head CT demonstrated her extensive subarachnoid hemorrhage. DSA demonstrated coarctation and occlusion of proximal thoracic aorta and occlusion of terminal aortic arch. Aortic-intracranial CTA confirmed that the patient had aortic coarctation complicated with anterior communicating artery aneurysm...
January 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29323299/rotation-in-c-ii-emitting-gas-in-two-galaxies-at-a-redshift-of-6-8
#11
Renske Smit, Rychard J Bouwens, Stefano Carniani, Pascal A Oesch, Ivo Labbé, Garth D Illingworth, Paul van der Werf, Larry D Bradley, Valentino Gonzalez, Jacqueline A Hodge, Benne W Holwerda, Roberto Maiolino, Wei Zheng
The earliest galaxies are thought to have emerged during the first billion years of cosmic history, initiating the ionization of the neutral hydrogen that pervaded the Universe at this time. Studying this 'epoch of reionization' involves looking for the spectral signatures of ancient galaxies that are, owing to the expansion of the Universe, now very distant from Earth and therefore exhibit large redshifts. However, finding these spectral fingerprints is challenging. One spectral characteristic of ancient and distant galaxies is strong hydrogen-emission lines (known as Lyman-α lines), but the neutral intergalactic medium that was present early in the epoch of reionization scatters such Lyman-α photons...
January 10, 2018: Nature
https://www.readbyqxmd.com/read/29322320/is-there-a-relationship-between-the-load-distribution-on-the-tibial-plateau-and-hip-knee-ankle-angle-after-tka
#12
Takao Kaneko, Norihiko Kono, Yuta Mochizuki, Hiroyasu Ikegami, Yoshiro Musha
INTRODUCTION: This study asked whether differences in coronal alignment after total knee arthroplasty (TKA) affect the load distribution on the tibial plateau. The aim of this study was to investigate the correlation between coronal alignment and the load distribution on the tibial plateau after TKA, using three-dimensional multi-detector-row-computed tomography (3D-MDCT). MATERIALS AND METHODS: In this study, we performed 84 cementless TKA with porous tantalum modular tibial component (PTMT) and divided into three groups based on post-operative hip-knee-ankle (HKA) angle: varus alignment group (n = 22), (176° ≧) neutral alignment group (n = 45), (180° ± 3°), and valgus alignment group (n = 17) (184° ≦)...
January 10, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29321188/far-red-light-detection-in-the-shoot-regulates-lateral-root-development-through-the-hy5-transcription-factor
#13
Kasper van Gelderen, Chiakai Kang, Richard Paalman, Diederik H Keuskamp, Scott Hayes, Ronald Pierik
Plants in dense vegetation compete for resources and detect competitors through reflection of far-red (FR) light from surrounding plants. This reflection causes a reduced red(R):FR ratio, which is sensed through phytochromes. Low R:FR induces shade avoidance responses of the shoot and also changes the root system architecture, although this has received little attention so far. Here we investigate the molecular mechanisms through which light detection in the shoot regulates root development in Arabidopsis thaliana...
January 9, 2018: Plant Cell
https://www.readbyqxmd.com/read/29320715/subcortical-pathways-to-extrastriate-visual-cortex-underlie-residual-vision-following-bilateral-damage-to-v1
#14
Sara Ajina, Holly Bridge
Residual vision, or blindsight, following damage to the primary visual cortex (V1) has been investigated for almost half a century. While there have been many studies of patients with unilateral damage to V1, far fewer have examined bilateral damage, mainly due to the rarity of such patients. Here we re-examine the residual visual function and underlying pathways of previously studied patient SBR who, as a young adult, suffered bilateral damage restricted to V1 which rendered him cortically blind. While earlier work compared his visual cortex to healthy, sighted participants, here we consider how his visual responses and connections compare to patients with unilateral damage to V1 in addition to sighted participants...
January 7, 2018: Neuropsychologia
https://www.readbyqxmd.com/read/29319400/deep-lateral-wall-orbital-decompression-following-strabismus-surgery-in-patients-with-type-ii-ophthalmic-graves-disease
#15
Michael P Ellis, Emily C Broxterman, Alan R Hromas, Thomas J Whittaker, Jason A Sokol
PURPOSE: Surgical management of ophthalmic Graves' disease traditionally involves, in order, orbital decompression, followed by strabismus surgery and eyelid surgery. Nunery et al. previously described two distinct sub-types of patients with ophthalmic Graves' disease; Type I patients exhibit no restrictive myopathy (no diplopia) as opposed to Type II patients who do exhibit restrictive myopathy (diplopia) and are far more likely to develop new-onset worsening diplopia following medial wall and floor decompression...
January 10, 2018: Orbit
https://www.readbyqxmd.com/read/29313300/the-effect-of-educational-intervention-based-on-health-belief-model-and-social-support-on-promoting-skin-cancer-preventive-behaviors-in-a-sample-of-iranian-farmers
#16
Ali Khani Jeihooni, Tayebeh Rakhshani
Skin cancer is one of the most common cancers in Iran. Farmers are exposed to the sun's ultraviolet radiation due to their job and are susceptible to skin cancer. The aim of this study is to survey the effect of educational intervention based on health belief model and social support on promoting skin cancer preventive behaviors in farmers of Fasa City, Fars province, Iran. In this quasi-experimental study, 200 farmers (100 in experimental group and 100 in control group) in Fasa City, Fars, Iran, were selected in 2017...
January 8, 2018: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/29305411/the-importance-of-the-photosynthetic-gibbs-effect-in-the-elucidation-of-the-calvin-benson-bassham-cycle
#17
REVIEW
Oliver Ebenhöh, Stephanie Spelberg
The photosynthetic carbon reduction cycle, or Calvin-Benson-Bassham (CBB) cycle, is now contained in every standard biochemistry textbook. Although the cycle was already proposed in 1954, it is still the subject of intense research, and even the structure of the cycle, i.e. the exact series of reactions, is still under debate. The controversy about the cycle's structure was fuelled by the findings of Gibbs and Kandler in 1956 and 1957, when they observed that radioactive 14CO2 was dynamically incorporated in hexoses in a very atypical and asymmetrical way, a phenomenon later termed the 'photosynthetic Gibbs effect'...
January 5, 2018: Biochemical Society Transactions
https://www.readbyqxmd.com/read/29303469/percutaneous-transforaminal-endoscopic-discectomy-compared-with-microendoscopic-discectomy-for-lumbar-disc-herniation-1-year-results-of-an-ongoing-randomized-controlled-trial
#18
Zihao Chen, Liangming Zhang, Jianwen Dong, Peigen Xie, Bin Liu, Qiyou Wang, Ruiqiang Chen, Feng Feng, Bu Yang, Tao Shu, Shangfu Li, Yang Yang, Lei He, Mao Pang, Limin Rong
OBJECTIVE A prospective randomized controlled study was conducted to clarify whether percutaneous transforaminal endoscopic discectomy (PTED) results in better clinical outcomes and less surgical trauma than microendoscopic discectomy (MED). METHODS In this single-center, open-label, randomized controlled trial, patients were included if they had persistent signs and symptoms of radiculopathy with corresponding imaging-confirmed lumbar disc herniation. Patients were randomly allocated to the PTED or the MED group by computer-generated randomization codes...
January 5, 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29302786/intraoperative-changes-in-corneal-structure-during-excimer-laser-phototherapeutic-keratectomy-ptk-assessed-by-intraoperative-optical-coherence-tomography
#19
Sebastian Siebelmann, Jens Horstmann, Paula Scholz, Björn Bachmann, Mario Matthaei, Manuel Hermann, Claus Cursiefen
PURPOSE: Excimer laser phototherapeutic keratectomy (PTK) is a safe treatment for superficial corneal opacities, e.g., in corneal dystrophies or degenerations. Nevertheless, no standardized treatment protocols are available and intraoperative monitoring was not possible, so far. Here we evaluate the potential benefits of the intraoperative assessment by microscope-integrated intraoperative optical coherence tomography (MI-OCT) of corneal optical properties during PTK. METHODS: Retrospective study of eight patients (one male, seven females; age range, 43-80 years, mean = 66...
January 4, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29301705/an-automated-approach-to-enhance-the-thermographic-evaluation-on-orofacial-regions-in-lateral-facial-thermograms
#20
Jaspreet Singh, Ajat Shatru Arora
Segmentation of characteristic facial regions has often been an initial step of thermographic analysis in face recognition and clinical diagnosis. Moreover, fast and accurate thermographic analysis on characteristic areas is highly reliant on segmentation approach. Usually, frontal and lateral projections are used to capture the facial thermograms. The significant role of lateral facial thermography to diagnose the various problems associated with orofacial regions has been remarkable in many studies. So far, no study has presented an automatic approach for the segmentation of characteristic areas in lateral facial thermograms...
January 2018: Journal of Thermal Biology
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