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https://www.readbyqxmd.com/read/28226338/opioids-inhibit-angiogenesis-in-a-chorioallantoic-membrane-model
#1
Haktan Karaman, Adnan Tufek, Evren Karaman, Orhan Tokgoz
BACKGROUND: Angiogenesis is an important characteristic of cancer. Switching from the avascular phase to the vascular phase is a necessary process for tumor growth. Therefore, research in cancer treatment has focused on angiogenesis as a drug target. Despite the widespread use of opioids to treat pain in patients with cancer, little is known about the effect of these drugs on vascular endothelium and angiogenesis. OBJECTIVES: We aimed to investigate the efficacies of morphine, codeine, and tramadol in 3 different concentrations on angiogenesis in hens' eggs...
February 2017: Pain Physician
https://www.readbyqxmd.com/read/28219963/overdose-risk-in-young-children-of-women-prescribed-opioids
#2
Yaron Finkelstein, Erin M Macdonald, Alejandro Gonzalez, Marco L A Sivilotti, Muhammad M Mamdani, David N Juurlink
BACKGROUND AND OBJECTIVE: Over the past 20 years, the prescribing of opioids has increased dramatically in North America, with parallel increases in opioid addiction, overdose, and associated deaths. We examined whether young children of women prescribed opioids were at increased risk of opioid overdose. METHODS: We conducted a population-based, nested case control study in Ontario, Canada, between 2002 and 2015. We identified children aged ≤10 years, whose mothers received publicly funded prescriptions for an opioid or a nonsteroidal antiinflammatory drug (comparator analgesic) in the preceding year...
February 20, 2017: Pediatrics
https://www.readbyqxmd.com/read/28217928/fast-determination-of-codeine-orphenadrine-promethazine-scopolamine-tramadol-and-paracetamol-in-pharmaceutical-formulations-by-capillary-electrophoresis
#3
Rafael R Cunha, Michelle M A C Ribeiro, Rodrigo A A Muñoz, Eduardo M Richter
Paracetamol is an active ingredient commonly found in pharmaceutical formulations in combination with one of the following compounds: codeine, orphenadrine, promethazine, scopolamine, and tramadol. In this work, we propose a unique analytical method for determination of these active ingredients in pharmaceutical samples. The method is based on capillary electrophoresis with capacitively coupled contactless conductivity detection. The separation was achieved on a fused silica capillary (50 cm total length, 40 cm effective length, and 50 μm id) using an optimized background electrolyte composed of 20 mmol L(-1) β-alanine/4 mmol L(-1) sodium chloride/4 μmol L(-1) sodium hydroxide (pH = 9...
February 20, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28199917/desomorphine-krokodil-an-overview-of-its-chemistry-pharmacology-metabolism-toxicology-and-analysis
#4
REVIEW
Diego Hernando Ângulo Florez, Ana Maria Dos Santos Moreira, Pedro Rafael da Silva, Ricardo Brandão, Marcella Matos Cordeiro Borges, Fernando José Malagueño de Santana, Keyller Bastos Borges
BACKGROUND: "Krokodil" or "Crocodile" is an illegal homemade desomorphine drug obtained from chemical reactions of commercial codeine drugs with several other powerful and highly toxic chemical agents increasing its addiction and hallucinogenic effects when compared with other morphine analogues. METHODS: This paper summarizes a complete review about an old drug called desomorphine (Krokodil), presenting its chemistry, pharmacology, metabolism, toxicology and analysis...
January 31, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28183374/experiences-of-codeine-use-misuse-and-dependence-application-of-liese-and-franz-s-cognitive-developmental-model-of-substance-abuse
#5
Marie Claire Van Hout, Ian Norman, Eileen Rich, Michael Bergin
BACKGROUND: Misuse of codeine-containing medicines is an emerging public health issue. AIMS: We present the application of Liese and Franz's (1996) cognitive developmental model of substance abuse to the trajectory from legitimate codeine use for pain, towards that of therapeutic and other forms of misuse, and physical and psychological dependence. It illustrates a cognitive behavioural analysis of the experiences of codeine misusers - which 'surfaces' the specific beliefs, thoughts, emotions and behaviours of this group of hidden codeine dependent individuals, who are distinct and unique from other opioid-dependent cohorts...
February 10, 2017: Behavioural and Cognitive Psychotherapy
https://www.readbyqxmd.com/read/28167034/stwrky8-transcription-factor-regulates-benzylisoquinoline-alkaloid-pathway-in-potato-conferring-resistance-to-late-blight
#6
Kalenahalli N Yogendra, Dhananjay Dhokane, Ajjamada C Kushalappa, Felipe Sarmiento, Ernesto Rodriguez, Teresa Mosquera
The resistance to late blight is either qualitative or quantitative in nature. Quantitative resistance is durable, but challenging due to polygenic inheritance. In the present study, the diploid potato genotypes resistant and susceptible to late blight, were profiled for metabolites. Tissue specific metabolite analysis of benzylisoquinoline alkaloids (BIAs) in response to pathogen infection revealed increased accumulation of morphinone, codeine-6-glucuronide and morphine-3-glucuronides. These BIAs are antimicrobial compounds and possibly involved in cell wall reinforcement, especially through cross-linking cell wall pectins...
March 2017: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/28161136/efficacy-of-oral-diclofenac-with-or-without-codeine-for-pain-control-after-invasive-bilateral-third-molar-extractions
#7
P Zupelari-Goncalves, G M Weckwerth, A M Calvo, L F Simoneti, T J Dionisio, D T Brozoski, E A Torres, J R P Lauris, F A C Faria, C F Santos
Postoperative pain and inflammation after oral surgery is mostly managed using non-steroidal anti-inflammatory drugs (NSAIDs). However, opioids combined with NSAIDs may improve pain management in patients, especially after traumatic oral surgery. Few studies have compared NSAIDs with and without opioid use after oral and maxillofacial surgery. This randomized, double-blind, cross-over study compared the clinical efficacy of either diclofenac (50mg) and codeine (50mg) or diclofenac alone (50mg) for the management of postoperative pain after invasive third molar surgery...
February 1, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28159714/pain-intensity-during-ultrasound-assessment-of-uterine-cavity-and-tubal-patency-with-and-without-painkiller-a-prospective-observational-study
#8
Inga Ludwin, Wellington P Martins, Carolina O Nastri, Artur Ludwin
OBJECTIVE: To determine the pain intensity and incidence of mild/severe pain during the ultrasound assessment of the uterine cavity and tubal patency using saline, air/saline and foam as contrasts with and without painkiller. DESIGN: Prospective observational study. DESIGN: Classification: Canadian Task Force II-1. SETTING: Private clinic. PATIENTS: Three hundred infertile women who were consecutively submitted to uterine cavity and tubal patency assessment by ultrasound using saline, air, and foam in single exam between Oct-2012 and Nov-2013...
January 31, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28156625/clinical-and-health-care-setting-of-patients-admitted-at-pain-control-center-hospice-of-solofra-a-feasibility-model-of-end-of-life-care-in-the-avellino-province-of-italy
#9
Carmela Fasano, Luisa M Rizzo, A M Strollo, Elena De Vinco, Vincenzo Landolfi, Elena Altieri, Mario Nicola Vittorio Ferrante, Sergio Canzanella, Giuseppe Servillo, Lucia Genua, Maddalena Zampi, Gaetano D'Onofrio
: 59 Background: The Pain Control Center Hospice of Solofra (Italy) is managed with a mixed public / private, the first experience in the Campania region.We have evaluated the treatment procedures and the clinical outcome to make a comparison by between 123 evaluable patients in palliative care in 2015 and 232 evaluable patients in the biennium 2012-2014. METHODS: The following characteristics: patient gender, mean hospitalization time, differentiation between cancer and non cancer patients, medical weapon use, venous access type, enteral and parenteral feeding, pain killer use,Karnofsky scale...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28132703/drug-safety-and-adverse-drug-reaction-reporting-behavior-related-to-outpatient-opioid-replacement-therapy-results-from-a-survey-among-physicians
#10
Maximilian Gahr, Jonas Eller, Maurice Cabanis, Christoph Hiemke, Roland W Freudenmann, Bernhard J Connemann, Dirk Lang, Carlos Schönfeldt-Lecuona
To study drug safety and the reporting behavior of adverse drug reactions (ADR) related to agents used for opioid replacement therapy (ORT) we conducted a cross-sectional questionnaire-based telephone survey among physicians who provide outpatient ORT in Germany (n=176; response rate=55.7%). Most respondents (n=97/55.1%) reported that they observe ADR related to buprenorphine, (dihydro)codeine, and (levo)methdone rarely (n=38/21.6%), very rarely (n=39/22.2%) or never (n=20/11.4%). Methadone was reported to be most frequently associated with the occurrence of ADR (n=82/46...
March 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/28123198/do-pharmacists-have-a-role-in-recommending-codeine-for-pain-management-australian-perspectives
#11
(no author information available yet)
No abstract text is available yet for this article.
November 2016: Canadian Journal of Hospital Pharmacy
https://www.readbyqxmd.com/read/28119266/drugs-in-hair-part-i-metabolisms-of-major-drug-classes
#12
REVIEW
R M White
Currently, hair can be reliably tested for the presence of drugs. However, one major drawback to the use of parent drugs is the question of potential external or environmental contamination. The analysis of metabolites to confirm the use of the parent drugs was proposed in this short review. The development of hair as a test matrix and the incorporation of xenobiotics, in general, into the hair matrix were discussed. What constitutes an appropriate metabolite for drug testing to mirror the use of a parent drug was proposed and discussed...
January 2017: Forensic Science Review
https://www.readbyqxmd.com/read/28112544/roadside-survey-on-alcohol-and-drug-use-among-drivers-in-the-arctic-county-of-finnmark-norway
#13
Ragnhild E G Jamt, Hallvard Gjerde, Per T Normann, Stig T Bogstrand
OBJECTIVE: To determine the prevalence of alcohol and potentially impairing drugs among the general driving population in Finnmark and to compare the prevalence among Norwegian, Russian and other foreign drivers by analyzing samples of oral fluid. METHODS: In collaboration with local police, drivers were selected for a voluntary and anonymous study using a multistage cluster sampling procedure (selection of roads, time intervals, and drivers within each interval) from September 2014 to October 2015...
January 23, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28111065/changes-in-provider-prescribing-patterns-after-implementation-of-an-emergency-department-prescription-opioid-policy
#14
Scott R Osborn, Julianna Yu, Barbara Williams, Maria Vasilyadis, C Craig Blackmore
BACKGROUND: Prescription opioid-associated abuse and overdose is a significant cause of morbidity and mortality in the United States. Opioid prescriptions generated from emergency departments (EDs) nationwide have increased dramatically over the past 20 years, and opioid-related overdose deaths have become an epidemic, according to the Centers for Disease Control and Prevention. OBJECTIVE: Our aim was to determine the effectiveness of implementing a prescription policy for opioids on overall opioid prescribing patterns in a hospital ED...
January 19, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28110169/lack-of-overlap-and-large-discrepancies-in-the-characteristics-of-the-deceased-in-two-sources-of-drug-death-a-linkage-study-of-the-cause-of-death-and-the-police-registries-in-norway-2007-2009
#15
Ellen Johanna Amundsen
BACKGROUND: Registries for drug deaths may include different persons and provide different characteristics of the deceased. The aim of this study was to establish whether a database of drug-induced deaths (Cause of Death Registry (CDR) using the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) definition and the Police registry of drug deaths) included the same persons and provided the same characteristics of the deceased and thus yielded the same information for establishing targeted prevention measures...
January 19, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28081042/detection-of-hydrocodone-and-morphine-as-metabolites-in-oral-fluid-by-lc-ms-ms-in-patients-prescribed-codeine
#16
Robert E West, Maria G Guevara, Charles Mikel, Ruben Gamez
A retrospective analysis of oral fluid drug testing results using LC-MS/MS was performed to determine the prevalence rates in oral fluid for codeine (COD) and 3 COD metabolites-morphine (MOR), norhydrocodone (NHC), and hydrocodone (HCOD). Oral fluid samples were collected using Quantisal oral fluid collection device (Immunalysis Inc.) and submitted to Millennium Health, LLC for the routine drug analysis by LC-MS/MS. Consistent with previously published literature, COD was the primary analyte detected in oral fluid after the use of COD...
February 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/28070817/medicines-containing-codeine-perspectives-of-medical-professionals-in-the-republic-of-ireland
#17
M Foley, T Carney, R Harris, E Fitzpatrick, A Rapca-Veillet, M C Van Hout
AIMS: The aim of the study was to examine prescribing professional's perceptions on prescribed and OTC medicines, containing codeine in the Republic of Ireland. A secondary aim was to examine perceptions on codeine dependence, screening and treatment. METHODS: A cross-sectional study of a nationally representative group of prescribing professionals was conducted using a questionnaire containing a number of open and closed ended items. Data were analysed using SPSS version 21 and content analysis techniques...
January 9, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28035699/lack-of-respiratory-depression-in-paracetamol-codeine-combination-overdoses
#18
Simon P E Heppell, Geoffrey K Isbister
BACKGROUND: Codeine containing analgesics are commonly taken in overdose, but the frequency of respiratory depression is unknown. We investigated whether paracetamol-codeine combination overdoses caused respiratory depression more than paracetamol alone. METHODS: We reviewed deliberate self-poisoning admissions with paracetamol (>2 g) and paracetamol-codeine combinations presenting to a tertiary toxicology unit (1987-2013). Demographic information, clinical effects, treatment (naloxone, length of stay[LOS], mechanical ventilation) were extracted from a prospective database...
December 30, 2016: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28027389/paracetamol-acetaminophen-with-or-without-codeine-or-dihydrocodeine-for-neuropathic-pain-in-adults
#19
REVIEW
Philip J Wiffen, Roger Knaggs, Sheena Derry, Peter Cole, Tudor Phillips, R Andrew Moore
BACKGROUND: Paracetamol, either alone or in combination with codeine or dihydrocodeine, is commonly used to treat chronic neuropathic pain. This review sought evidence for efficacy and harm from randomised double-blind studies. OBJECTIVES: To assess the analgesic efficacy and adverse events of paracetamol with or without codeine or dihydrocodeine for chronic neuropathic pain in adults. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, and Embase from inception to July 2016, together with reference lists of retrieved papers and reviews, and two online study registries...
27, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28025374/effect-of-local-anesthetic-concentration-0-2-vs-0-1-ropivacaine-on-pulmonary-function-and-analgesia-after-ultrasound-guided-interscalene-brachial-plexus-block-a-randomized-controlled-study
#20
Andrew K Wong, Lauren Georgiades Keeney, Liting Chen, Rebekah Williams, Jiabin Liu, Nabil M Elkassabany
OBJECTIVE: This study aims to assess diaphragmatic excursion and measure pulmonary functions as measures of the degree to which the phrenic nerve is blocked after ISB with two different concentrations of ropivacaine: 0.2% and 0.1%. DESIGN: Randomized, double-blinded study. SETTING AND PATIENTS: Ambulatory surgical facility. SUBJECTS: Fifty patients undergoing shoulder arthroscopy for rotator cuff repair. METHODS: Patients were randomized to receive ultrasound-guided ISB with 20 mL of either 0...
December 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
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