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https://www.readbyqxmd.com/read/27540235/patient-carers-recollection-of-medicines-related-information-from-an-out-patient-clinic-appointment
#1
Jeff Aston, Natasha Patel, Justin Smuels, Teena Aujla, Georgia Malesi, Chi Huynh, Keith Wilson, David Terry
AIM: To identify what medicines related information children/young people or their parents/carers are able to recall following an out-patient clinic appointment. METHOD: A convenience sample of patients' prescribed at least one new long-term (>6 weeks) medicine were recruited from a single UK paediatric hospital out-patient pharmacy.A face-to-face semi-structured questionnaire was administered to participants when they presented with their prescription. The questionnaire included the following themes: names of the medicines, therapeutic indication, dose regimen, duration of treatment and adverse effects...
September 2016: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/27401372/-inappropriate-medication-use-among-chilean-older-people
#2
Alvaro Passi, Paula Margozzini, Eduardo Valenzuela, Trinidad Hoyl, Pedro Paulo Marín, Marcela Carrasco, Ricardo Olea, Homero Gac
BACKGROUND: Inappropriate medication use in older people is an important source of adverse events and complications. AIM: To determine the frequency of inappropriate medication use in the general population. MATERIAL AND METHODS: As part of the 2010 Chilean National Health Survey, 1,048 persons aged 65 years or more were interviewed about medication use. The information obtained was analyzed using standardized Beer’s criteria, adapted for the Chilean population, to define inappropriate medication use...
April 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/27223124/-new-drugs-for-horses-and-production-animals-in-2015
#3
Ilka Ute Emmerich
In 2015, four newly developed active pharmaceutical ingredients for horses and food-producing animals were released on the German market for veterinary drug products. These were the bisphosphonate Clodronic Acid (Osphos®), the 5-hydroxytryptamine (2A) receptor antagonist Ketanserin (Vulketan®), the aminoglycoside antibiotic Paromomycin (Parofor®) and the antibiotic Thiamphenicol (TAF Spray®) from the fenicole group. With Chlorphenamine, a temporary not available active ingredient was reapproved in a new drug...
June 16, 2016: Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere
https://www.readbyqxmd.com/read/26071045/histamine-and-seizures-implications-for-the-treatment-of-epilepsy
#4
H Yokoyama, K Iinuma
Experimental studies have indicated that the central histaminergic neuron system plays an important role in the inhibition of seizures through stimulation of histamine H1 receptors, especially in the developmental period. This has therapeutic implications for currently available drugs that act at histamine receptors. H1 receptor antagonists, including classical antihistamines and anti-allergy drugs, occasionally induce convulsions in healthy children and patients with epilepsy. In particular, promethazine, carbinoxamine, mepyramine (pyrilamine) and ketotifen should be used with caution in these patients...
May 1996: CNS Drugs
https://www.readbyqxmd.com/read/25421375/study-of-the-enantioseparation-capability-of-chiral-dual-system-based-on-chondroitin-sulfate-c-in-ce
#5
Jiaquan Chen, Yingxiang Du, Fenxia Zhu, Bin Chen, Qi Zhang, Shuaijing Du, Ping Li
It has been reported that chiral dual system is able to improve the enantioseparation of enantiomers in many cases. Currently, the dual systems involved in CE chiral separation are mostly dual CDs systems, and the polysaccharides-based chiral dual system was reported in only one paper. To the best of our knowledge, the use of chondroitin sulfate C (CSC)-based dual system for enantiomeric separation has not been reported previously. Herein, four CSC-based chiral dual systems, namely CSC/glycogen, CSC/chondroitin sulfate A (CSA), CSC/hydroxypropyl-β-CD (HP-β-CD), as well as CSC/β-CD (β-CD), were evaluated for the first time for their enantioseparation capability by CE in this paper...
February 2015: Electrophoresis
https://www.readbyqxmd.com/read/25410034/summertime-and-the-patient-is-itchy
#6
Andrew Tabner, Carl McQueen, Susanne Hewitt
A 21-year-old man presented to the emergency department with a 36 h history of a painful, itchy maculopapular rash and associated vesicles to his arms and neck. He had no history of exposure to new chemicals or hygiene products and no significant medical history. His physiological observations were normal and systemic examination was unremarkable. On close inspection the rash was noted to be present only on areas of skin exposed while wearing a polo shirt. On further questioning it transpired that he had been gardening 12 h prior to the development of the rash...
November 19, 2014: BMJ Case Reports
https://www.readbyqxmd.com/read/24626481/development-of-a-convenient-in-vivo-hepatotoxin-assay-using-a-transgenic-zebrafish-line-with-liver-specific-dsred-expression
#7
Xiaoyan Zhang, Caixia Li, Zhiyuan Gong
Previously we have developed a transgenic zebrafish line (LiPan) with liver-specific red fluorescent protein (DsRed) expression under the fabp10a promoter. Since red fluorescence in the liver greatly facilitates the observation of liver in live LiPan fry, we envision that the LiPan zebrafish may provide a useful tool in analyses of hepatotoxicity based on changes of liver red fluorescence intensity and size. In this study, we first tested four well-established hepatotoxins (acetaminophen, aspirin, isoniazid and phenylbutazone) in LiPan fry and demonstrated that these hepatotoxins could significantly reduce both liver red fluorescence and liver size in a dosage-dependent manner, thus the two measurable parameters could be used as indicators of hepatotoxicity...
2014: PloS One
https://www.readbyqxmd.com/read/24501793/reversible-bilateral-blepharoptosis-following-oxaliplatin-infusion-a-case-report-and-literature-review
#8
REVIEW
Giuseppe Fanetti, Laura A M Ferrari, Filippo Pietrantonio, Roberto Buzzoni
Oxaliplatin, a platinum analogue employed in the treatment of colorectal cancer and various other neoplasms, is characterized by a broad range of adverse events. Peripheral neuropathy is probably the most peculiar and clinically relevant toxicity associated with its use and can be distinguished into two types: acute and chronic neurotoxicity.We report a case of acute reversible bilateral palpebral ptosis and dyspnea without bronchospasm or laryngospasm which occurred at the end of the third administration of adjuvant oxaliplatin by infusion for stage III colon cancer in a 54-year-old woman...
September 2013: Tumori
https://www.readbyqxmd.com/read/24261438/symptomatic-treatment-of-the-common-cold-with-a-fixed-dose-combination-of-paracetamol-chlorphenamine-and-phenylephrine-a-randomized-placebo-controlled-trial
#9
RANDOMIZED CONTROLLED TRIAL
Paulo Dornelles Picon, Marisa Boff Costa, Rafael da Veiga Picon, Lucia Costa Cabral Fendt, Maurício Leichter Suksteris, Indara Carmanim Saccilotto, Alicia Dorneles Dornelles, Luis Felipe Carissimi Schmidt
BACKGROUND: The common cold and other viral airway infections are highly prevalent in the population, and their treatment often requires the use of medications for symptomatic relief. Paracetamol is as an analgesic and antipyretic; chlorphenamine is an antihistamine; and phenylephrine, a vasoconstrictor and decongestant. This randomized, double-blind, placebo-controlled trial sought to evaluate the efficacy and safety of a fixed-dose combination of paracetamol, chlorphenamine and phenylephrine in the symptomatic treatment of the common cold and flu-like syndrome in adults...
November 22, 2013: BMC Infectious Diseases
https://www.readbyqxmd.com/read/24254834/simultaneous-quantitative-analysis-of-dextromethorphan-dextrorphan-and-chlorphenamine-in-human-plasma-by-liquid-chromatography-electrospray-tandem-mass-spectrometry
#10
Ying Ding, Kai Huang, Lan Chen, Jie Yang, Wen-Yan Xu, Xue-Jiao Xu, Ru Duan, Jing Zhang, Qing He
A sensitive and accurate HPLC-MS/MS method was developed for the simultaneous determination of dextromethorphan, dextrorphan and chlorphenamine in human plasma. Three analytes were extracted from plasma by liquid-liquid extraction using ethyl acetate and separated on a Kromasil 60-5CN column (3 µm, 2.1 × 150 mm) with mobile phase of acetonitrile-water (containing 0.1% formic acid; 50:50, v/v) at a flow rate of 0.2 mL/min. Quantification was performed on a triple quadrupole tandem mass spectrometer in multiple reaction monitoring mode using positive electrospray ionization...
March 2014: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/23640698/a-national-survey-of-price-and-affordability-of-key-essential-medicines-for-children-in-sri-lanka
#11
R Balasubramaniam, B V S H Benaragama, Shalini Sri Ranganathan
OBJECTIVE: To investigate the price and affordability of key essential medicines for children in Sri Lanka. METHODS: This national survey investigated the prices and affordability of 25 key essential medicines for children in private sector pharmacies using the WHO/Health Action International (HAI) medicine price methodology. Data were collected from a representative sample of 48 private sector pharmacies selected from 8 Provinces using a multistage clustered approach...
April 2014: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/23600148/-rapid-identification-15-effective-components-of-anti-common-cold-medicine-with-mrm-by-lc-ms-ms
#12
Jian-Guo Jiang, Xi-Ru Zhang, Yi-Hua Zhang, Geng-Shen Song
This paper reports the establishment of a method for rapid identification 15 effective components of anti common cold medicine (paracetamol, aminophenazone, pseudoephedrine hydrochloride, methylephedrine hydrochloride, caffeine, amantadine hydrochloride, phenazone, guaifenesin, chlorphenamine maleate, dextromethorphen hydrobromide, diphenhydramine hydrochloride, promethazine hydrochloride, propyphenazone, benorilate and diclofenac sodium) with MRM by LC-MS/MS. The samples were extracted by methanol and were separated from a Altantis T3 column within 15 min with a gradient of acetonitrile-ammonium acetate (containing 0...
January 2013: Yao Xue Xue Bao, Acta Pharmaceutica Sinica
https://www.readbyqxmd.com/read/23303483/combined-use-of-ionic-liquid-and-%C3%AE-cd-for-enantioseparation-of-12-pharmaceuticals-using-ce
#13
Lihua Zuo, Heng Meng, Jingjing Wu, Zhen Jiang, Shuying Xu, Xingjie Guo
In this study, the enantioseparation of zopiclone, repaglinide, chlorphenamine maleate, brompheniramine maleate, dioxopromethazine hydrochloride, promethazine hydrochloride, liarozole, carvedilol, homatropine hydrobromide, homatropine methylbromide, venlafaxine, and sibutramine hydrochloride has been investigated using β-CD in combination with a chiral ionic liquid (IL), 1-ethyl-3-methylimidazolium-L-lactate. The influence of the type of IL and its concentration, BGE pH, and chain length of the IL cations on the resolution are discussed...
February 2013: Journal of Separation Science
https://www.readbyqxmd.com/read/23256382/-preparation-and-applications-of-a-supported-liquid-liquid-extraction-column-with-a-composite-diatomite-material
#14
Jianmin Bao, Zhishuang Ma, Ying Sun, Yongzun Wang, Youxin Li
A rapid and special supported liquid-liquid extraction (SLE) column was developed with a composite diatomite material. The SLE column was evaluated by high performance liquid chromatography (HPLC) with acidic, neutral and alkaline compounds dissolved in water. Furthermore, some real complex samples were also analyzed by HPLC with the SLE method. The recoveries of benzoic acid (acidic), p-nitroaniline (alkaline) and 4-hydroxy-benzoic methyl ester (neutral) treated by the SLE column were 90.6%, 98.1% and 97.7%...
August 2012: Se Pu, Chinese Journal of Chromatography
https://www.readbyqxmd.com/read/22206469/formulation-and-evaluation-of-novel-coated-floating-tablets-of-bergenin-and-cetirizine-dihydrochloride-for-gastric-delivery
#15
Shuang He, Feng Li, Dan Zhou, Junrong Du, Yuan Huang
A novel coated gastric floating drug-delivery system (GFDDS) of bergenin (BN) and cetirizine dihydrochloride (CET) was developed. First, the pharmacodynamic studies were performed and the results revealed that the new compounds of bergenin/cetirizine dihydrochloride had comparative efficacy as commercial products (bergenin/chlorphenamine maleate) but with fewer side effects on central nervous system (CNS). Subsequently, bergenin was formulated as an extended-release core tablet while cetirizine dihydrochloride was incorporated into the gastric coating film for immediate release...
October 2012: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/22164746/a-national-survey-of-availability-of-key-essential-medicines-for-children-in-sri-lanka
#16
R Balasubramaniam, B V S H Beneragama, S Sri Ranganathan
OBJECTIVES: To investigate the availability of key essential medicines for children in Sri Lanka. METHODS: This national survey assessed the availability of 25 key essential medicines for children using the WHO/Health Action International medicine price methodology. Data were collected from a representative sample of 40 public hospitals (Outpatients Department pharmacies), 40 private and 8 'Rajya Osusala' (ROS) pharmacies. The hospitals and pharmacies were selected from 8 provinces using a multistage clustered approach to represent different levels of public hospitals...
September 2011: Ceylon Medical Journal
https://www.readbyqxmd.com/read/21903238/ndma-formation-kinetics-from-three-pharmaceuticals-in-four-water-matrices
#17
Ruqiao Shen, Susan A Andrews
N, N-nitrosodimethylamine (NDMA) is an emerging disinfection by-product (DBP) that has been widely detected in many drinking water systems and commonly associated with the chloramine disinfection process. Some amine-based pharmaceuticals have been demonstrated to form NDMA during chloramination, but studies regarding the reaction kinetics are largely lacking. This study investigates the NDMA formation kinetics from ranitidine, chlorphenamine, and doxylamine under practical chloramine disinfection conditions...
November 1, 2011: Water Research
https://www.readbyqxmd.com/read/21899852/coupling-frontal-elution-paper-chromatography-with-desorption-corona-beam-ionization-mass-spectrometry-for-rapid-analysis-of-chlorphenamine-in-herbal-medicines-and-dietary-supplements
#18
Yun-Qing Huang, Jing-Qing You, Junsheng Zhang, Wenjian Sun, Li Ding, Yu-Qi Feng
We developed a convenient method by coupling frontal elution paper chromatography with desorption corona beam ionization mass spectrometry (DCBI-MS) for rapid determination of chlorphenamine added in herbal medicines or dietary supplements. In this method, the ethanol extract of the herbal products was spotted directly onto an isosceles triangular filter paper sheet, and then the paper sheet was developed under strong elution condition with the sample zone migrating at the solvent front. The analyte was finally condensed at the V-shaped tip which could then be placed under the visible plasma beam of DCBI for ionization...
October 14, 2011: Journal of Chromatography. A
https://www.readbyqxmd.com/read/21898800/synthesis-and-application-of-clindamycin-succinate-as-a-novel-chiral-selector-for-capillary-electrophoresis
#19
Jianfeng Wu, Peng Liu, Li Wang, Hailin Tian, Qingwei Wang, Shengyong Zhang
A novel chiral selector, clindamycin succinate, was synthesized and first used as a chiral selector in capillary electrophoresis (CE). The chiral resolution ability of this kind of clindamycin derivation was studied by CE using some racemic drugs as model analytes. From the experimental results, it was found that both resolution and selectivity of the selector were dependent on the following parameters: concentration of chiral selectors, pH of the running buffer, temperature of the capillary column, applied voltage and organic modifier used...
September 2011: Journal of Separation Science
https://www.readbyqxmd.com/read/21886654/rare-case-of-red-man-syndrome-in-a-female-patient-treated-with-oral-vancomycin-for-clostridium-difficile-diarrhoea
#20
Mani Nallasivan, Fergus Maher, Krishna Murthy
A 58-year-old Caucasian woman was admitted for knee replacement but during the postoperative period she developed sepsis due to pneumonia, which was treated with coamoxiclav and then piperacillin (for 2 weeks). She had renal failure, which needed haemofiltration. During her recovery she had diarrhoea due to Clostridium difficile, which was not controlled with metronidazole. Vancomycin was therefore given, but she developed urticarial erythematous skin rash and hence it was stopped. She was not on any other new medications and a vasculitic screen was negative...
2009: BMJ Case Reports
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