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https://www.readbyqxmd.com/read/27698519/uterotonics-for-non-emergent-caesarean-section-protocol-change-during-uk-licensed-drug-shortage
#1
C Malone, J R Acheson, J D Hinds, M H McComiskey
The aim was to assess the efficacy of Syntometrine (®) (500 micrograms ergometrine with 5 units oxytocin) as an appropriate alternative first-line uterotonic for use in elective caesarean section (CS) during a national shortage of UK-licensed IV oxytocin from April-June 2014. An observational study was performed involving 2 groups of 22 women undergoing elective CS in a UK DGH during this period. Primary endpoints included mean estimated blood loss (EBL), haemoglobin drop post-operatively and transfusion requirement...
September 2016: Ulster Medical Journal
https://www.readbyqxmd.com/read/27593398/customised-management-of-the-third-stage-of-labour
#2
Edward Springhall, Euan M Wallace, Lynne Stewart, Michelle Knight, Joanne C Mockler, Miranda Davies-Tuck
BACKGROUND: Postpartum haemorrhage (PPH) rates are increasing worldwide. The rate is particularly high in women undergoing an induced or augmented labour. In response to this, we altered our hospital's protocol for the management of the third stage of labour to recommend Syntometrine, in preference to oxytocin alone, for women being induced or augmented. We set out to assess the impact of the protocol change on the PPH rate. MATERIALS AND METHODS: A random sample of 1200 women who had a singleton, term vaginal birth before and after the protocol change was taken...
September 5, 2016: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/27423315/in-vitro-contractile-effects-of-agents-used-in-the-clinical-management-of-postpartum-haemorrhage
#3
John J Morrison, David A Crosby, Denis J Crankshaw
Uterine atony is a major cause of postpartum haemorrhage and maternal mortality. However, the comparative pharmacology of agents used to treat this condition is poorly understood. This study evaluates, using human pregnant myometrium in vitro, a range of contractile parameters for agents used in the clinical treatment of atonic postpartum haemorrhage. The effects of oxytocin, carbetocin, ergometrine, carboprost, syntometrine and misoprostol were investigated in 146 myometrial strips from 19 donors. The potency and maximal response values were obtained, and compared, using both maximal amplitude and mean contractile force as indices of contraction...
October 15, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27268381/carbetocin-versus-syntometrine-for-prevention-of-postpartum-hemorrhage-after-cesarean-section
#4
Ahmed Mohamed Maged, Ahmed Shaker Ragab, Noura Elnassery, Walaa Ai Mostafa, Sherif Dahab, Amal Kotb
OBJECTIVE: To compare effectiveness and tolerability of carbetocin versus syntometrine in prevention of postpartum hemorrhage (PPH) after cesarean section (CS). METHODS: A double-blind randomized study conducted on 300 pregnant subjected randomly either to single 100 μg IV dose of carbetocin (150 women) or combination of 5 IU oxytocin and 0.2 mg ergometrine (150 women) after fetal extraction and before placental removal. Primary outcome parameter was the occurrence of PPH...
June 8, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/26816300/breastfeeding-or-nipple-stimulation-for-reducing-postpartum-haemorrhage-in-the-third-stage-of-labour
#5
REVIEW
Parvin Abedi, Shayesteh Jahanfar, Farideh Namvar, Jasmine Lee
BACKGROUND: Oxytocin and prostaglandin are hormones responsible for uterine contraction during the third stage of labour. Receptors in the uterine muscles are stimulated by exogenous or endogenous oxytocin leading to uterine contractions. Nipple stimulation or breastfeeding are stimuli that can lead to the secretion of oxytocin and consequent uterine contractions. Consequently, uterine contractions can reduce bleeding during the third stage of labour. OBJECTIVES: To investigate the effects of breastfeeding or nipple stimulation on postpartum haemorrhage (PPH) during the third stage of labour...
January 27, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/25579116/carbetocin-for-the-prevention-of-postpartum-hemorrhage-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#6
REVIEW
Bohong Jin, Yongming Du, Fubin Zhang, Kemei Zhang, Lulu Wang, Lining Cui
OBJECTIVE: To compare the efficacy and safety profile of carbetocin with other uterotonic agents in preventing postpartum hemorrhage. METHODS: PubMed, Web of Science, Scopus and EBSCOhost were searched for relevant randomized controlled trials published until September 2013. RESULTS: Carbetocin was associated with a significantly reduced need for additional uterotonic agents (RR = 0.68, 95% CI: 0.55-0.84, I(2 )= 4%) compared with oxytocin in women following cesarean delivery...
2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/24902190/should-midwives-delay-administration-of-syntometrine
#7
Helen Haggertay
No abstract text is available yet for this article.
June 2008: Midwives
https://www.readbyqxmd.com/read/24616793/carbetocin-vs-syntometrine-in-prevention-of-postpartum-hemorrhage-a-double-blind-randomized-control-trial
#8
Mansoureh Samimi, Azam Imani-Harsini, Masoumeh Abedzadeh-Kalahroudi
BACKGROUND: Postpartum hemorrhage is a significant cause of maternal mortality and morbidity, worldwide. OBJECTIVES: The aim of this study was to compare the efficacy between carbetocin and syntometrine in prevention of postpartum hemorrhage. MATERIALS AND METHODS: This study was a double blind randomized clinical trial that carried out on 200 pregnant women referred to Shabiehkhani maternity center of Kashan, during 2011. The first group received intramuscular syntometrine and the second group received intramuscular carbetocin after placental delivery...
September 2013: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/23296037/which-uterotonic-is-better-to-prevent-the-postpartum-hemorrhage-latest-news-in-terms-of-clinical-efficacy-side-effects-and-contraindications-a-systematic-review
#9
REVIEW
Salvatore Gizzo, Tito Silvio Patrelli, Stefania Di Gangi, Monica Carrozzini, Carlo Saccardi, Alessandra Zambon, Anna Bertocco, Simone Fagherazzi, Donato D'Antona, Giovanni Battista Nardelli
BACKGROUND: Postpartum hemorrhage (PPH) is a potentially fatal complication of vaginal and cesarean deliveries. The active management of the third stage of labor provides administration of prophylactic uterotonic drugs just before or immediately after delivery, since they reduce the risk of PPH by 60%. OBJECTIVE: Overview on all available uterotonics for PPH prevention to clarify indications and contraindications in choice among drugs. SEARCH STRATEGY: Systematic review of the literature...
September 2013: Reproductive Sciences
https://www.readbyqxmd.com/read/22513931/carbetocin-for-preventing-postpartum-haemorrhage
#10
REVIEW
Lin-Lin Su, Yap-Seng Chong, Miny Samuel
BACKGROUND: Postpartum haemorrhage (PPH) is one of the major contributors to maternal mortality and morbidity worldwide. Active management of the third stage of labour has been proven to be effective in the prevention of PPH. Syntometrine is more effective than oxytocin but is associated with more side effects. Carbetocin, a long-acting oxytocin agonist, appears to be a promising agent for the prevention of PPH. OBJECTIVES: To determine if the use of oxytocin agonist is as effective as conventional uterotonic agents for the prevention of PPH, and assess the best routes of administration and optimal doses of oxytocin agonist...
2012: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/22336812/carbetocin-for-preventing-postpartum-haemorrhage
#11
REVIEW
Lin-Lin Su, Yap-Seng Chong, Miny Samuel
BACKGROUND: Postpartum haemorrhage (PPH) is one of the major contributors to maternal mortality and morbidity worldwide. Active management of the third stage of labour has been proven to be effective in the prevention of PPH. Syntometrine is more effective than oxytocin but is associated with more side effects. Carbetocin, a long-acting oxytocin agonist, appears to be a promising agent for the prevention of PPH. OBJECTIVES: To determine if the use of oxytocin agonist is as effective as conventional uterotonic agents for the prevention of PPH, and assess the best routes of administration and optimal doses of oxytocin agonist...
2012: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/21336835/carbetocin-versus-syntometrine-in-the-management-of-third-stage-of-labor-following-vaginal-delivery
#12
RANDOMIZED CONTROLLED TRIAL
Alsaeed A Askar, Mohamed Taha Ismail, Amro Abo El-Ezz, Noha H Rabie
OBJECTIVE: To assess and compare the efficacy and safety of a single intramuscular dose of carbetocin to a single intramuscular dose of syntometrine in managing the third stage of labor following vaginal delivery among women with low risk factors for postpartum hemorrhage. STUDY DESIGN: Prospective double-blind randomized controlled study. SUBJECTS AND METHODS: The study included 240 healthy women with viable normal singleton pregnancies achieving normal vaginal delivery at or beyond 37 weeks' gestation during the period from May 2009 to December 2009 at TAIBA Hospital in Kuwait...
December 2011: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/20789817/use-of-syntometrine-in-prevention-of-post-partum-haemorrhage
#13
M P Embrey, D T Barber, J H Scudamore
No abstract text is available yet for this article.
May 25, 1963: British Medical Journal (1857-1980)
https://www.readbyqxmd.com/read/20789488/use-of-syntometrine-in-rotunda-hospital-district-maternity-service
#14
J McGrath, A D Browne
No abstract text is available yet for this article.
August 25, 1962: British Medical Journal (1857-1980)
https://www.readbyqxmd.com/read/20569439/policies-for-care-during-the-third-stage-of-labour-a-survey-of-maternity-units-in-syria
#15
MULTICENTER STUDY
Hosam E Matar, Muhammad Q Almerie, Mohamad Alsabbagh, Muhammad Jawoosh, Yara Almerie, Asma Abdulsalam, Lelia Duley
BACKGROUND: Care for women during the third stage aims to reduce the risk of major haemorrhage, but is very variable. The current World Health Organisation (WHO) recommendation is that care should include administration of a uterotonic (oxytocin, if it is available) soon after birth of the baby, delayed cord clamping, and delivery of the placenta by controlled cord traction. METHODS: To ascertain care policies used during the third stage of labour in maternity units in Syria, we conducted a survey of 69 maternity units in obstetric and general public hospitals...
2010: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/20492659/care-during-the-third-stage-of-labour-a-postal-survey-of-uk-midwives-and-obstetricians
#16
Diane Farrar, Derek Tuffnell, Rebecca Airey, Lelia Duley
BACKGROUND: There are two approaches to care during the third stage of labour: Active management includes three components: administration of a prophylactic uterotonic drug, cord clamping and controlled cord traction. For physiological care, intervention occurs only if there is clinical need. Evidence to guide care during the third stage is limited and there is variation in recommendations which may contribute to differences in practice. This paper describes current UK practice during the third stage of labour...
2010: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/20043525/a-randomized-comparison-of-rectal-misoprostol-with-syntometrine-on-blood-loss-in-the-third-stage-of-labour
#17
RANDOMIZED CONTROLLED TRIAL
J Harriott, L Christie, S Wynter, V DaCosta, H Fletcher, M Reid
OBJECTIVES: a) To compare the clinical effect of rectal misoprostol with intramuscular syntometrine in reducing blood loss in the third stage of labour b) to determine the severity and incidence of side effects of both drugs and c) to measure blood loss, patient tolerance and acceptance of rectal misoprostol. METHODS: One hundred and forty parturients were randomly allocated to receive intramuscular syntometrine (syntocinon 10 IU + ergometrine 0.5 mg) or rectal misoprostol 400 microg within five minutes of the delivery of the anterior shoulder Blood loss was measured by the use of a plastic collection drape...
June 2009: West Indian Medical Journal
https://www.readbyqxmd.com/read/19616358/prevention-of-postpartum-haemorrhage-with-the-oxytocin-analogue-carbetocin
#18
REVIEW
Werner Rath
Postpartum haemorrhage is the leading cause of maternal mortality worldwide: 67-80% of cases are caused by uterine atony. Preventive measures include prophylactic drug use to aid uterine contraction after delivery, thus avoiding severe blood loss and reducing maternal morbidity and mortality. Carbetocin is a synthetic analogue of oxytocin with a half-life approximately 4-10 times longer than that reported for oxytocin. It combines the safety and tolerability profile of oxytocin with the sustained uterotonic activity of injectable ergot alkaloids...
November 2009: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/19603316/a-randomised-controlled-trial-comparing-the-efficacy-of-intramuscular-syntometrine-and-intravenous-syntocinon-in-preventing-postpartum-haemorrhage
#19
RANDOMIZED CONTROLLED TRIAL
M Rashid, A Clark, M H Rashid
This randomised controlled trial aimed to compare the efficacy of intramuscular syntometrine with intravenous syntocinon, in preventing postpartum haemorrhage. A total of 686 women were randomised into two groups; one receiving intramuscular syntometrine and the other receiving intravenous syntocinon, as part of the active management of the third stage of labour. There was no difference in the mean blood loss between the two groups. However, there was an increased incidence of having a diastolic blood pressure of >90, 30 min after the delivery (p = 0...
July 2009: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/19538418/carbetocin-versus-syntometrine-for-the-third-stage-of-labour-following-vaginal-delivery-a-double-blind-randomised-controlled-trial
#20
RANDOMIZED CONTROLLED TRIAL
L L Su, M Rauff, Y H Chan, N Mohamad Suphan, T P Lau, A Biswas, Y S Chong
OBJECTIVE: Prevention of postpartum haemorrhage is essential in the pursuit of improved health care for women. However, limited literature is available for comparing the use of oxytocin agonist carbetocin with syntometrine in women undergoing vaginal deliveries. We aimed to compare intramuscular carbetocin with intramuscular syntometrine for the routine prevention of postpartum haemorrhage in women who deliver vaginally. DESIGN: Prospective double-blind randomised controlled trial...
October 2009: BJOG: An International Journal of Obstetrics and Gynaecology
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