Mohammad Amin Momeni-Moghaddam, Gholamreza Asadikaram, Mohammad Masoumi, Erfan Sadeghi, Hamed Akbari, Moslem Abolhassani, Alireza Farsinejad, Morteza Khaleghi, Mohammad Hadi Nematollahi, Shahriar Dabiri, Mohammad Kazemi Arababadi
The molecular mechanisms of opium action with regard to coronary artery disease (CAD) have not yet been determined. The aim of this study was to evaluate the effect of opium on the expression of scavenger receptors including CD36, CD68, and CD9 tetraspanin in monocytes and the plasma levels of tumor necrosis factor alpha (TNF-α), interferon gamma (IFN-γ), malondialdehyde (MDA), and nitric oxide metabolites (NOx ) in CAD patients with and without opium addiction. This case-control study was conducted on three groups: (1) opium-addicted CAD patients (CAD + OA, n = 30); (2) CAD patients with no opium addiction (CAD, n = 30); and (3) individuals without CAD and opium addiction as the control group (Ctrl, n = 17)...
January 10, 2023: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research