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glyceryl trinitrate

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https://www.readbyqxmd.com/read/29783558/re-efficacy-and-safety-of-med2005-a-topical-glyceryl-trinitrate-formulation-in-the-treatment-of-erectile-dysfunction-a-randomized-crossover-study
#1
https://www.readbyqxmd.com/read/29779296/the-assessment-and-management-of-chest-pain-in-primary-care-a-focus-on-acute-coronary-syndrome
#2
Richard Thomsett, Louise Cullen
BACKGROUND: Chest pain is a common presentation and diagnosis can be challenging. There are many causes for chest pain, including life-threatening conditions such as acute coronary syndrome (ACS), which can prove difficult to diagnose. OBJECTIVE: This article focuses on diagnosis and early management of patients with possible ACS. Key differentials and essential primary care investigations and management are outlined. Hospital-based risk stratification and management are described, providing an outline of what patients can expect if referred to hospital...
May 2018: Australian journal of general practice
https://www.readbyqxmd.com/read/29703002/embolic-retinal-and-choroidal-vascular-occlusion-after-peribulbar-triamcinolone-injection-a-case-report
#3
Gang Li, Dongdong Xu, Zhirou Hu, Hui Li
RATIONALE: Retinal and choroidal vascular occlusion is a vision-threatening complication of therapeutic injections in the facial region. The early identification and early treatment are necessary to reduce the risk of harm to the patient. PATIENT CONCERNS: We report an extremely rare case of embolic retinal and choroidal vascular occlusion after peribulbar triamcinolone injection in a patient with thyroid-associated ophthalmopathy. DIAGNOSES: Central retinal artery occlusion...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29666943/the-gtn-patch-a-simple-and-effective-new-approach-to-cardioprotection
#4
Derek M Yellon, Zhenhe He, Rayomand Khambata, Amrita Ahluwalia, Sean M Davidson
There remains a significant un-met need to reduce the extent of myocardial injury caused by ischaemia and reperfusion injury in patients experiencing an ST-elevation MI. Although nitric oxide is central to many cardioprotective strategies currently undergoing investigation, cardioprotection from the delivery of nitrates/nitrites has been inconsistently observed. The route of administration appears to be a critical variable. The glyceryl trinitrate (GTN) patch is commonly used as a simple and practical means of delivering nitric oxide to patients with ischaemic heart disease, but whether acute cardioprotection can be achieved by application of a GTN patch has not been investigated before...
April 17, 2018: Basic Research in Cardiology
https://www.readbyqxmd.com/read/29569958/influence-of-long-term-treatment-with-glyceryl-trinitrate-on-remote-ischemic-conditioning
#5
Marie Hauerslev, Sivagowry Rasalingam Mørk, Kasper Pryds, Hussain Contractor, Jan Hansen, Nichlas Riise Jespersen, Jacob Johnsen, Gerd Heusch, Petra Kleinbongard, Rajesh Kharbanda, Hans Erik Bøtker, Michael Rahbek Schmidt
Remote ischemic conditioning (RIC) protects against sustained myocardial ischemia. Due to overlapping mechanisms this protection may be altered by glyceryl trinitrate (GTN), which is commonly used in the treatment of patients with chronic ischemic heart disease. We investigated whether long-term GTN treatment modifies the protection by RIC in rat myocardium and human endothelium. We studied infarct size (IS) in rat hearts subjected to global ischemia-reperfusion (I/R) in vitro and endothelial function in healthy volunteers subjected to I/R of the upper arm...
March 23, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29545561/non-invasive-markers-of-cardiovascular-risk-in-patients-with-subclinical-hypothyroidism-a-systematic-review-and-meta-analysis-of-27-case-control-studies
#6
Kecheng Yao, Tianming Zhao, Linghai Zeng, Jianming Yang, Yanqun Liu, Qian He, Xiulan Zou
It has been reported that subclinical hypothyroidism (SCH) is closely related to subclinical atherosclerosis. According to the impact of SCH on noninvasive markers of cardiovascular risk, we fulfilled a meta-analysis of included studies to provide an integrated overview. We searched electronic databases and included all relevant studies involving SCH and epicardial adipose tissue (EAT), carotid intima-media thickness (CIMT), pulse wave velocity (PWV), flow-mediated dilation (FMD) and glyceryl trinitrate-induced dilation (GNT- induced dilation)...
March 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29496901/evaluation-of-human-coronary-vasodilator-function-predicts-future-coronary-atheroma-progression
#7
Samuel L Sidharta, Timothy J Baillie, Stuart Howell, Stephen J Nicholls, Natalie Montarello, Satoshi Honda, Daisuke Shishikura, Sinny Delacroix, Susan Kim, John F Beltrame, Peter J Psaltis, Stephen G Worthley, Matthew I Worthley
OBJECTIVE: Coronary vasodilator function and atherosclerotic plaque progression have both been shown to be associated with adverse cardiovascular events. However, the relationship between these factors and the lipid burden of coronary plaque remains unknown. These experiments focus on investigating the relationship between impaired coronary vasodilator function (endothelium dependent (salbutamol) and endothelium independent (glyceryl trinitrate)) and the natural history of atheroma plaque progression and lipid burden using dual modality intravascular ultrasound (IVUS) and near-infrared spectroscopy (NIRS) imaging...
March 1, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29473355/-clinical-research-of-vasospasm-and-vagus-reflex-during-radial-artery-puncture-treated-with-auricular-point-sticking
#8
Xiaoyan Fan, Yanping Liu, Jinhong Xie, Yushan Chen, Yanyan Cao
OBJECTIVE: To evaluate the effect and clinical value of auricular point sticking for the diagnosis and treatment of vasospasm and vagus reflex during radial artery puncture, including radial artery spasm (RAS) and coronary artery spasm (CAS). METHODS: A total of 480 patients were randomized into an observation group (224 cases) and a control group (256 cases). Percutaneous coronary intervention and usual care in perioperative period were used in the control group...
February 12, 2018: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29431638/s-nitrosylation-of-ciap1-switches-cancer-cell-fate-from-tnf%C3%AE-tnfr1-mediated-cell-survival-to-cell-death
#9
Sabrina Romagny, Sarra Bouaouiche, Géraldine Lucchi, Patrick Ducoroy, Jean B Bertoldo, Hernan Terenzi, Ali Bettaieb, Stéphanie Plenchette
TNFα is a prominent proinflammatory cytokine and a critical mediator for the development of many types of cancer such as breast, colon, prostate, cervical, skin, liver, and chronic lymphocytic leukemia. Binding of TNFα to TNFR1 can lead to divergent signaling pathways promoting predominantly NF-κB activation but also cell death. We report here that the nitric oxide (NO) donor glyceryl trinitrate (GTN) converts TNFα, generated from immune cells or cancer cells stimulated by chemotherapy, into a prodeath mediator in colon and mammary cancer cells...
April 15, 2018: Cancer Research
https://www.readbyqxmd.com/read/29355580/sitting-time-is-negatively-related-to-microvascular-endothelium-dependent-function-in-rheumatoid-arthritis
#10
Sally A M Fenton, Aamer Sandoo, George S Metsios, Joan L Duda, George D Kitas, Jet J C S Veldhuijzen van Zanten
BACKGROUND: Sedentary behaviour is linked to increased cardiovascular disease risk in Rheumatoid Arthritis (RA), but the biological processes underlying this relationship are not understood. OBJECTIVES: To investigate the cross-sectional associations of habitual sedentary behaviour, with endothelial function in RA. METHODS: Sixty-eight RA patients (Mage = 55 ± 12 years) underwent Laser Doppler Imaging with iontophoresis, to assess microvascular endothelium-dependent (acetylcholine, ACh) and endothelium-independent (sodium nitroprusside, SNP) function...
May 2018: Microvascular Research
https://www.readbyqxmd.com/read/29317214/case-series-use-of-glyceryl-trinitrate-patches-to-improve-peripheral-circulation-in-children-with-severe-neurodisability
#11
Frances Morrison, Jack Fairhurst, Charlie Fairhurst
AIM: Evaluation of topical Glyceryl trinitrate as a therapeutic option to improve peripheral circulation in 16 children with severe complex neurodisability, poor capillary return and signs of vascular insufficiency, including discomfort. METHODS: If insufficient improvement in capillary return was obtained using conservative measures, a 5 mg GTN patch was placed each day on the front of the tibia of each leg. Children were reviewed clinically for up to 12 months of treatment...
December 31, 2017: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29306609/efficacy-and-safety-of-med2005-a-topical-glyceryl-trinitrate-formulation-in-the-treatment-of-erectile-dysfunction-a-randomized-crossover-study
#12
David J Ralph, Ian Eardley, Jorg Taubel, Paul Terrill, Tim Holland
BACKGROUND: Current treatments for erectile dysfunction (ED) have some limitations. AIM: This study evaluated the efficacy and tolerability of MED2005, a 0.2% glyceryl trinitrate topical gel, formulated into an enhanced absorption topical delivery system (DermaSys), administered on demand, in the treatment of ED. METHODS: This randomized, double-blinded, placebo-controlled, phase II crossover trial involved 232 men with ED (231 treated, 230 assessed for efficacy) and their partners...
February 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29241947/effects-of-sublingual-glyceryl-trinitrate-administration-on-the-quality-of-preprocedure-ct-angiography-performed-to-plan-prostate-artery-embolization
#13
Mark W Little, Andrew C Macdonald, Phil Boardman, Mark J Bratby, Suzie Anthony, Mohammed Hadi, Charles R Tapping
PURPOSE: To determine the effects of sublingual glyceryl trinitrate (GTN) on the quality of planning computed tomography (CT) angiography performed prior to prostate artery embolization (PAE). MATERIALS AND METHODS: A retrospective cohort study was performed on patients who had previously undergone CT angiography before a procedure for PAE at our institution. Early CT angiography studies for PAE at our single center had initially been performed without GTN. These were compared to subsequent CT angiography studies that had been performed with GTN, after a previously implemented change in practice...
February 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29061124/dapagliflozin-acutely-improves-endothelial-dysfunction-reduces-aortic-stiffness-and-renal-resistive-index-in-type-2-diabetic-patients-a-pilot-study
#14
Anna Solini, Livia Giannini, Marta Seghieri, Edoardo Vitolo, Stefano Taddei, Lorenzo Ghiadoni, Rosa Maria Bruno
BACKGROUND: Sodium-glucose cotransporter-2 inhibitors reduce blood pressure (BP) and renal and cardiovascular events in patients with type 2 diabetes through not fully elucidated mechanisms. Aim of this study was to investigate whether dapagliflozin is able to acutely modify systemic and renal vascular function, as well as putative mechanisms. METHODS: Neuro-hormonal and vascular variables, together with 24 h diuresis, urinary sodium, glucose, isoprostanes and free-water clearance were assessed before and after a 2-day treatment with dapagliflozin 10 mg QD in sixteen type 2 diabetic patients; data were compared with those obtained in ten patients treated with hydrochlorothiazide 12...
October 23, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29040598/effect-of-metformin-on-vascular-function-in-children-with-type-1-diabetes-a-12-month-randomized-controlled-trial
#15
RANDOMIZED CONTROLLED TRIAL
Jemma J A Anderson, Jennifer J Couper, Lynne C Giles, Catherine E Leggett, Roger Gent, Brian Coppin, Alexia S Peña
Context: Children with type 1 diabetes have vascular dysfunction preceding atherosclerosis. Early interventions are needed to reduce cardiovascular disease. Objective: To evaluate the effect of metformin on vascular function in children with type 1 diabetes. Design: Twelve-month double-blind, randomized, placebo-controlled trial. Setting: Tertiary pediatric diabetes clinic. Participants: Ninety children (8 to 18 years of age), >50th percentile body mass index (BMI), with type 1 diabetes...
December 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29035982/comparison-of-the-effect-of-5-different-treatment-options-for-managing-patellar-tendinopathy-a-secondary-analysis
#16
Dafne van Rijn, Inge van den Akker-Scheek, Mirjam Steunebrink, Ron L Diercks, Johannes Zwerver, Henk van der Worp
OBJECTIVE: Currently, no treatments exist for patellar tendinopathy (PT) that guarantee quick and full recovery. Our objective was to assess which treatment option provides the best chance of clinical improvement and to assess the influence of patient and injury characteristics on the clinical effect of these treatments. DESIGN: A secondary analysis was performed on the combined databases of 3 previously performed double-blind randomized controlled trials. PATIENTS: In total, 138 patients with PT were included in the analysis...
October 10, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28928192/a-pragmatic-group-sequential-placebo-controlled-randomised-trial-to-determine-the-effectiveness-of-glyceryl-trinitrate-for-retained-placenta-got-it-a-study-protocol
#17
RANDOMIZED CONTROLLED TRIAL
Fiona C Denison, John Norrie, Julia Lawton, Jane E Norman, Graham Scotland, Gladys C McPherson, Alison McDonald, Mark Forrest, Jemma Hudson, Jane Brewin, Mathilde Peace, Cynthia Clarkson, Sheonagh Brook-Smith, Susan Morrow, Nina Hallowell, Laura Hodges, Kathryn F Carruthers
INTRODUCTION: A retained placenta is diagnosed when the placenta is not delivered following delivery of the baby. It is a major cause of postpartum haemorrhage and treated by the operative procedure of manual removal of placenta (MROP). METHODS AND ANALYSIS: The aim of this pragmatic, randomised, placebo-controlled, double-blind UK-wide trial, with an internal pilot and nested qualitative research to adjust strategies to refine delivery of the main trial, is to determine whether sublingual glyceryl trinitrate (GTN) is (or is not) clinically and cost-effective for (medical) management of retained placenta...
September 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28905197/systemic-glyceryl-trinitrate-reduces-anal-sphincter-tone-is-there-a-therapeutic-indication
#18
C Connolly, S Tierney, P Grace
BACKGROUND: Nitric oxide (NO) has diverse roles as a biological messenger. [1] Topically applied nitrate donors cause relaxation of the internal anal sphincter (IAS) and facilitate healing of anal fissures [2,3]. Systemic nitrates are commonly used for the treatment of ischaemic heart disease, yet the effects of systemically administered nitrates on the smooth muscle of the IAS are unknown. AIM: Our aim was to test the hypothesis that systemically administered nitrates at a normal dose, cause inhibition of anal sphincter activity...
May 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28901662/acute-hypoxaemia-and-vascular-function-in-healthy-humans
#19
N C S Lewis, A R Bain, K W Wildfong, D J Green, P N Ainslie
What is the central question of this study? Endothelium-dependent flow-mediated dilatation (FMD) is impaired during acute (60 min) exposure to moderate hypoxia. We examined whether FMD is impaired to the same degree during exposure to milder hypoxia. Additionally, we assessed whether smooth muscle vasodilatory capacity [glyceryl trinitrate (GTN)-induced dilatation] is impaired during acute hypoxic exposure. What is the main finding and its importance? A graded impairment in FMD and GTN-induced dilatation was evident during acute (≤60 min) exposure to mild and moderate hypoxia...
December 1, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28856479/calcitonin-gene-related-peptide-antagonism-and-cluster-headache-an-emerging-new-treatment
#20
REVIEW
Håkan Ashina, Lawrence Newman, Sait Ashina
Calcitonin gene-related peptide (CGRP) is a key signaling molecule involved in migraine pathophysiology. Efficacy of CGRP monoclonal antibodies and antagonists in migraine treatment has fueled an increasing interest in the prospect of treating cluster headache (CH) with CGRP antagonism. The exact role of CGRP and its mechanism of action in CH have not been fully clarified. A search for original studies and randomized controlled trials (RCTs) published in English was performed in PubMed and in ClinicalTrials...
December 2017: Neurological Sciences
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