Jeroen C de Jonge, Wouter M Sluis, Hendrik Reinink, Philip M Bath, Lisa J Woodhouse, Berber Zweedijk, Diederik van de Beek, Anne Hege Aamodt, Iris Alpers, Alfonso Ciccone, Laszlo Csiba, Jacques Demotes, Janika Kõrv, Iwona Kurkowska-Jastrzebska, Jesse Dawson, Malcolm R Macleod, George Ntaios, Sven Poli, Haralampos Milionis, Stefano Ricci, Silvia Cenciarelli, Paolo Candelaresi, Sebastiaan Ftm de Bruijn, Rohan Pathansali, Kailash Krishnan, Brian Clarke, Götz Thomalla, H Bart van der Worp
BACKGROUND: Infections and fever after stroke are associated with poor functional outcome or death. We assessed whether prophylactic treatment with anti-emetic, antibiotic, or antipyretic medication would improve functional outcome in older patients with acute stroke. METHODS: We conducted an international, 2∗2∗2-factorial, randomised, controlled, open-label trial with blinded outcome assessment in patients aged 66 years or older with acute ischaemic stroke or intracerebral haemorrhage and a score on the National Institutes of Health Stroke Scale ≥ 6...
January 2024: The Lancet regional health. Europe