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https://www.readbyqxmd.com/read/29784851/replacement-by-site-saturation-mutagenesis-of-residue-119-in-ndm-1-metallo-%C3%AE-lactamase-a-kinetic-study
#1
Francesca Marcoccia, Paola Sandra Mercuri, Moreno Galleni, Giuseppe Celenza, Gianfranco Amicosante, Mariagrazia Perilli
NDM-1 is a subclass B1 metallo-β-lactamase which exhibits a broad activity spectrum against β-lactam antibiotics. In this study we report the kinetic study of six Q119X variants obtained by site-directed mutagenesis on NDM-1. All Q119X variants were able to hydrolyze very efficiently carbapenems, penicillins and 1st , 2nd , 3rd and 4th generation cephalosporins. In particular, Q119E, Q119Y, Q119V and Q119K mutants showed an improvement of kcat/ Km towards penicillins respect to NDM-1. The catalytic efficiency of Q119K variant is about 65- and 70-fold higher than that of NDM-1 for benzylpenicillin and carbenicillin, respectively...
May 21, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29756174/phenotypic-detection-of-clinical-isolates-of-haemophilus-influenzae-with-altered-penicillin-binding-protein-3
#2
A Aguirre-Quiñonero, I C Pérez Del Molino, C García de la Fuente, M C Sanjuán, J Agüero, L Martínez-Martínez
The aims of this study were to determine the correlation of mutations in the ftsI gene (coding for PBP3) of Haemophilus influenzae with aminopenicillin resistance and to evaluate the 2017 European Committee for Antibiotic Susceptibility Testing (EUCAST) guidelines for clinical categorization of ampicillin, amoxicillin, and amoxicillin-clavulanate for strains with mutated PBP3 conferring resistance (rPBP3). A panel of 91 H. influenzae isolates was genetically characterized by sequencing of the fstI gene. For all the studied isolates, a screening with benzylpenicillin 1U (BP1) was carried out and minimum inhibitory concentrations (MICs) of ampicillin, amoxicillin, and amoxicillin-clavulanate were tested and interpreted according to EUCAST recommendations...
May 13, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29705391/stability-of-benzylpenicillin-potassium-and-ampicillin-in-an-elastomeric-infusion-pump
#3
Tomomi Nakamura, Yuki Enoki, Shunsuke Uno, Yoshifumi Uwamino, Osamu Iketani, Naoki Hasegawa, Kazuaki Matsumoto
Some infectious diseases, such as infective endocarditis, osteomyelitis, and abscesses, require treatment with long-term intravenous antimicrobial treatment. Therefore, the patient is required to stay in the hospital to receive therapy, which lowers their quality of life. Establishing an outpatient parenteral antimicrobial therapy (OPAT) by continuous infusion pump is desired in Japan to overcome these issues. However, the 24-h stability of antimicrobial agents dissolved in infusion solutions is unclear. Thus, we investigated the stability of antimicrobial agents in five different infusion solutions in a clinical setting...
April 25, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29683776/coagulase-negative-staphylococci-isolated-from-human-bloodstream-infections-showed-multidrug-resistance-profile
#4
Silvia H S P Pedroso, Savio H C Sandes, Robledo A T Filho, Alvaro C Nunes, Jose C Serufo, Luiz M Farias, Maria A R Carvalho, Maria R Q Bomfim, Simone G Santos
Coagulase-negative staphylococci (CNS) are important pathogens causing nosocomial infections worldwide with increasing resistance to antimicrobials. The aim of this study was to characterize resistance aspects of CNS isolated from patients with bloodstream infections acquired in hospitals in Belo Horizonte, MG, Brazil. Staphylococcus strains were characterized using repetitive sequence-based polymerase chain reaction (rep-PCR) fingerprinting with (GTG)5 primer. Phenotypic resistance was analyzed using AST-P5085 card (bioMérieuxVitek® )...
April 23, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29666731/ischemic-stroke-in-an-hiv-positive-patient-an-initial-presentation-of-neurosyphilis
#5
Kalimullah Jan, Rebecca Hoe Hui Min, Tan Seow Yen, Shekhawat Ravindra Singh
Ischemic stroke occurring in patients with human immunodeficiency virus (HIV) needs to be approached with a vast differential diagnosis in mind. We report a case of middle-aged male patient with immune reconstituted HIV on therapy without known cardiovascular risk factors who had a right middle cerebral artery territory infarct. After a thorough evaluation, he received a final diagnosis of neurosyphilis-associated vasculitis leading to stroke. He recovered without any neurological deficits following treatment with intravenous benzylpenicillin...
2018: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/29660106/safety-effectiveness-and-feasibility-of-outpatient-management-of-children-with-pneumonia-with-chest-indrawing-at-port-moresby-general-hospital-papua-new-guinea
#6
Rose Morre, Kone Sobi, Wendy Pameh, Paulus Ripa, John D Vince, Trevor Duke
Implementing the World Health Organization (WHO) recommendations on home-based management of pneumonia with chest indrawing is challenging in many settings. In Papua New Guinea, 120 children presenting with the WHO definition of pneumonia were screened for danger signs, comorbidities and hypoxaemia using pulse oximetry; 117 were appropriate for home care. We taught mothers about danger signs and when to return, using structured teaching materials and a video. The children were given a single dose of intramuscular benzylpenicillin, then sent home on oral amoxicillin for 5 days, with follow-up at Days 2 and 6...
April 6, 2018: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/29614602/-molecular-typing-characterization-of-food-borne-methicillin-resistant-staphylococcus-aureus-in-china
#7
Y Bai, W Wang, L Yan, S R Yang, S F Yan, Y P Dong, B C Zhao, Y Y Zhao, J Xu, Y J Hu, F Q Li
Objective: To analyses the antimicrobial resistance and molecular characterization of 21 MRSA isolates cultured from retail foods from different provinces in China, and evaluate the molecular typing methods. Methods: Twenty-one MRSA isolates were obtained from national foodborne pathogen surveillance network in 2012 (Chinese salad, n= 3; milk, n= 1; cake, n= 2; rice, n= 1; cold noodle, n= 1; spiced beef, n= 1; dumpling, n= 1; packed meal, n= 1; salad, n= 1; raw pork, n= 9). The antimicrobial resistance of 21 strains to 12 antimicrobial agents was tested by broth dilution method...
April 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29605795/acute-and-chronic-toxicity-assessment-of-benzylpenicillin-g-residue-in-heat-treated-animal-food-products
#8
Cheng Cui, Xiang Zhang, Yang Wang, Shiying Lu, Huijun Lu, Qi Hui, Waqas Ahmad, Yan Cai, Xilin Liu, Lingjiu Liu, Fengfeng Shi, Yanyan Liu, Ke Zhao, FeiFei Zhai, Yangzhen Xiang, Pan Hu, Yansong Li, Honglin Ren, Ningyi Jin, Zengshan Liu
The current level of penicillin use and its persisting residue in livestock is potentially concerning; the toxicity of penicillin residue in heat-treated animal food products (HAFP) is yet to be elucidated. In this study, the acute and chronic toxicity of benzylpenicillin G (BPG) residue in HAFP was investigated in a mouse model. The calculated LD50 of BPG heated to cooking temperature (BPHCT) was 933.04 mg kg-1 [b.w.] intraperitoneally corresponding to 3.75 times lower than its prototype. Mice fed on the experimental diet containing heat-treated beef with high BPG levels for 6 months displayed a reduction in body weight and altered serum values indicating for liver and renal function...
March 14, 2018: Chemosphere
https://www.readbyqxmd.com/read/29592767/drug-shortages-in-a-pediatric-stem-cell-transplantation-ward-challenges-and-implications-a-5-year-bilan
#9
B Claus, T Bauters, G Laureys
This article describes the implications of shortages of pharmaceutical products used in conditioning and supportive care regimens of pediatric patients undergoing a hematopoietic stem cell transplantation in a tertiary care hospital. Between July 2011 and July 2016, a total of 84 individual shortages, affecting 22 different drugs (79.8% supportive care drugs; 20.2% chemotherapeutics) were detected with a mean duration of 85 days (SD 138) per individual drug shortage. Eighteen shortages were critical and very urgent...
January 1, 2018: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29583053/correction-pharmacokinetics-of-intravenous-continuous-rate-infusions-of-sodium-benzylpenicillin-and-ceftiofur-sodium-in-adult-horses
#10
(no author information available yet)
No abstract text is available yet for this article.
April 2018: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/29540483/ampicillin-permeation-across-ompf-the-major-outer-membrane-channel-in-escherichia-coli
#11
Ishan Ghai, Harsha Bajaj, Jayesh Arun Bafna, Hussein Ali El Damrany Hussein, Mathias Winterhalter, Richard Wagner
The outer cell wall of the Gram-negative bacteria is a crucial barrier for antibiotics to reach their target. Here, we show that the chemical stability of the widely used antibiotic ampicillin is a major factor in the permeation across OmpF to reach the target in the periplasm. Using planar lipid bilayers we investigated the interactions and permeation of OmpF with ampicillin, its basic pH-induced primary degradation product (penicilloic acid), and the chemically more stable benzylpenicillin. We found that the solute-induced ion current fluctuation is 10 times higher with penicilloic acid than with ampicillin...
May 4, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29408014/dress-syndrome-due-to-benzylpenicillin-with-cross-reactivity-to-amoxicillin
#12
Timothy J Watts, Philip H Li, Rubaiyat Haque
No abstract text is available yet for this article.
January 31, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29379354/potentiation-of-antibiotic-activity-by-passiflora-cincinnata-mast-front-of-strains-staphylococcus-aureus-and-escherichia-coli
#13
Ana Luiza A Siebra, Larissa R Oliveira, Anita O B P B Martins, David C Siebra, Rosimeire S Albuquerque, Izabel Cristina Santiago Lemos, Gyllyandeson A Delmondes, Saulo R Tintino, Fernando G Figueredo, Jose Galberto M da Costa, Henrique D M Coutinho, Irwin R A Menezes, Cicero F B Felipe, Marta R Kerntopf
The development of new drugs from plants is an interesting alternative approach to overcoming microbial resistance. Passiflora cincinnata shows resistance to diseases and pests and a higher concentration of chemical components that may be useful in the pharmaceutical industry. We investigated the potential antimicrobial and antibiotic-modifying activity of hydroalcoholic extracts of leaves, stems, bark, pulp and seeds of P. cincinnata . The extracts were prepared by homogenization of material in 50% ethanol...
January 2018: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/29378710/evaluation-of-a-system-specific-function-to-describe-the-pharmacokinetics-of-benzylpenicillin-in-term-neonates-undergoing-moderate-hypothermia
#14
Yuma A Bijleveld, Timo R de Haan, Johanna H van der Lee, Floris Groenendaal, Peter H Dijk, Arno van Heijst, Rogier C J de Jonge, Koen P Dijkman, Henrica L M van Straaten, Monique Rijken, Inge A Zonnenberg, Filip Cools, Alexandra Zecic, Debbie H G M Nuytemans, Anton H van Kaam, Ron A A Mathôt
The pharmacokinetic (PK) properties of intravenous (i.v.) benzylpenicillin in term neonates undergoing moderate hypothermia after perinatal asphyxia were evaluated, as they have been unknown until now. A system-specific modeling approach was applied, in which our recently developed covariate model describing developmental and temperature-induced changes in amoxicillin clearance (CL) in the same patient study population was incorporated into a population PK model of benzylpenicillin with a priori birthweight (BW)-based allometric scaling...
April 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29355985/identification-of-t-cell-epitopes-from-benzylpenicillin-conjugated-to-human-serum-albumin-and-implication-in-penicillin-allergy
#15
M E Azoury, L Filì, R Bechara, N Scornet, L de Chaisemartin, R J Weaver, N Claude, B Maillere, P Parronchi, D Joseph, M Pallardy
BACKGROUND: There is in vitro evidence that T cells from allergic patients react to benzylpenicillin-human serum albumin (BP-HSA) bioconjugates. Our group has recently shown the existence of naïve CD4+ T cells recognizing BP-HSA in healthy donors. However, BP-haptenated peptides from HSA participating in the immunization of allergic patients have never been identified. The purpose of the present study is to identify immunodominant BP-haptenated peptides from HSA involved in immunization of patients to BP and to refine the frequency calculation of naïve CD4+ T cells recognizing BP...
January 22, 2018: Allergy
https://www.readbyqxmd.com/read/29340851/comparison-of-antibiotic-dosing-recommendations-for-neonatal-sepsis-from-established-reference-sources
#16
T B Y Liem, E M A Slob, J U M Termote, T F W Wolfs, A C G Egberts, C M A Rademaker
Background Incorrect dosing is the most frequent prescribing error in neonatology, with antibiotics being the most frequently prescribed medicines. Computer physician order entry and clinical decision support systems can create consistency contributing to a reduction of medication errors. Although evidence-based dosing recommendations should be included in such systems, the evidence is not always available and subsequently, dosing recommendations mentioned in guidelines and textbooks are often based on expert opinion...
January 16, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29340463/prevalence-of-and-risk-factors-associated-with-the-presence-of-staphylococcus-aureus-in-the-chronic-wounds-of-patients-treated-in-primary-health-care-settings-in-brazil
#17
Eliane Patricia Lino Pereira-Franchi, Maria Rachel Nogueira Barreira, Natália de Sousa Lima Moreira da Costa, Carlos Magno Castelo Branco Fortaleza, Maria de Lourdes Ribeiro de Souza da Cunha
INTRODUCTION: Wounds can be colonized by methicillin-resistant Staphylococcus aureus (MRSA). METHODS: We evaluated the prevalence of S. aureus and MRSA in the wounds of patients treated at Basic Health Units in Brazil and identified risk factors associated with their presence. RESULTS: The prevalence rates of S. aureus and MRSA were 51.5% and 8.7%, respectively. There was a correlation between the presence of S. aureus in wounds and nostrils (p<0...
November 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29287806/antibiotic-susceptibility-of-259-listeria-monocytogenes-strains-isolated-from-food-food-processing-plants-and-human-samples-in-germany
#18
Matthias Noll, Sylvia Kleta, Sascha Al Dahouk
BACKGROUND: The objective of this study was to evaluate the susceptibility of 259 Listeria monocytogenes strains isolated from food and food-processing environments and patient samples in Germany to 14 antibiotics widely used in veterinary and human medicine. L. monocytogenes strains were isolated mainly from milk and milk products and classified according to their molecular serotypes IIa (n=112), IIb (n=41), IIc (n=36), IVa (n=1), IVb (n=66), and IVb-v1 (n=3). METHODS: Susceptibility tests were performed by using the automated 96-well based microdilution system Micronaut-S...
December 26, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/29277663/oat1-and-oat3-also-mediate-the-drug-drug-interaction-between-piperacillin-and-tazobactam
#19
Shijie Wen, Changyuan Wang, Yingjie Duan, Xiaokui Huo, Qiang Meng, Zhihao Liu, Shilei Yang, Yanna Zhu, Huijun Sun, Xiaodong Ma, Siyun Yang, Kexin Liu
This study aimed to demonstrate that organic anion transporters (OATs) mediate the drug-drug interaction (DDI) between piperacillin and tazobactam. After co-administration with piperacillin in rats, the AUC of tazobactam in plasma was significantly increased, and t1/2β was prolonged with significant reduction in plasma clearance, renal clearance and cumulative urinary excretion. In rat and human kidney slices, probenecid, p-aminohippurate and benzylpenicillin inhibited the uptake of piperacillin and tazobactam...
February 15, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29261121/six-year-retrospective-review-of-hospital-data-on-antimicrobial-resistance-profile-of-staphylococcus-aureus-isolated-from-skin-infections-from-a-single-institution-in-greece
#20
Christina Stefanaki, Alexandra Ieronymaki, Theoni Matoula, Chrysseis Caroni, Evaggelia Polythodoraki, Stella-Eugenia Chryssou, George Kontochristopoulos, Christina Antoniou
Objective: To determine the prevalence of resistant strains of Staphylococcus aureus ( S. aureus ) isolated from Skin and soft tissue infections (SSTI) to various antibiotics. Material and Methods: All culture-positive results for S. aureus from swabs taken from patients presenting at one Greek hospital with a skin infection between the years 2010-2015 were examined retrospectively. Bacterial cultures, identification of S. aureus and antimicrobial susceptibility testing were performed using the disk diffusion method according to Clinical and Laboratory Standards Institute (CLSI) guidelines and European Committee on Antimicrobial testing (EUCAST) breakpoints...
December 20, 2017: Antibiotics
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