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https://www.readbyqxmd.com/read/28522308/development-of-a-ssdna-aptamer-for-detection-of-residual-benzylpenicillin
#1
A-Young Lee, Na-Reum Ha, In-Pil Jung, Sang-Heon Kim, A-Ru Kim, Moon-Young Yoon
Antibiotics are useful for improving the living conditions of livestock. However, residual antibiotics induce several human diseases such as food-borne illness and infection of carbapenem-resistant Enterobacteriaceae (CRE). In this study, the identification of a benzylpenicillin-specific aptamer was selected by rGO-SELEX (reduced Graphene Oxide-Systematic Evolution of Ligands by EXponential enrichment). A random ssDNA library was incubated with rGO for adsorption and eluted with benzylpenicillin. As a result of the selection process, a DNA aptamer was found that specifically bound to benzylpenicillin with high binding affinity, Kd = 383...
May 15, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/28512690/translational-studies-on-a-ready-to-use-intramuscular-injection-of-penethamate-for-bovine-mastitis
#2
I G Tucker, R Jain, F Alawi, K Nanjan, O Bork
Bovine mastitis caused by bacterial infections of the mammary gland (udder) of dairy cows is a costly pathology for the dairy industry due to direct and indirect losses in production. Penethamate, a pro-drug of benzylpenicillin, is used by intramuscular injection (IM). The existing products are powders which must be reconstituted in water-for-injection and this presents difficulties in the field. Penethamate is too unstable to be formulated as an aqueous formulation but a chemically stable suspension formulation was possible in certain oils; however, some literature suggests that such formulations would have unacceptable prolonged release...
May 16, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28391717/modulation-of-antibiotic-activity-by-the-hydroalcoholic-extract-from-leaves-of-caryocar-coriaceum-wittm
#3
Luís J de Lacerda Neto, A G B Ramos, M R Kerntopf, H D M Coutinho, L J Quintans-Junior, J R G S Almeida, J Ribeiro-Filho, I R A Menezes
The aim of this study was to identify the presence of tannins, phenols and flavonoids on the hydroalcoholic extract of Caryocar coriaceum leaves (HECCL) and to determine the antioxidant and antibacterial activity of this extract. The extract was tested alone (1024-1 μg/mL) or associated (MIC/8) with several antibiotics in order to identify any antibacterial activity against multiresistant bacterial strains (Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa). The existence of tannins, total phenols (901...
April 9, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28348807/successful-treatment-of-listeria-monocytogenes-prosthetic-valve-endocarditis-using-rifampicin-and-benzylpenicillin-in-combination-with-valve-replacement
#4
Tasnim Hasan, William Chik, Sharon Chen, Jen Kok
Introduction.Listeria monocytogenes is an uncommon cause of prosthetic valve endocarditis (PVE). Recommended antimicrobial therapy typically includes intravenous β-lactams with or without synergistic aminoglycosides. In vitro studies have previously identified antagonism when rifampicin has been used in combination with β-lactams. However, in vivo data of rifampicin use are limited despite its enhanced anti-biofilm activity. Case presentation. A 63-year-old male presented with fever and back pain. L. monocytogenes bacteraemia and bioprosthetic aortic valve endocarditis was confirmed, along with spinal discitis and osteomyelitis...
February 2017: JMM Case Reports
https://www.readbyqxmd.com/read/28348790/streptococcus-pneumoniae-bacteraemia-due-to-parotitis-in-a-patient-with-systemic-sclerosis-and-secondary-sj%C3%A3-gren-s-syndrome
#5
Irene Yuen Lin Yii, Jamie Bee Xian Tan, Warren Weng Seng Fong
INTRODUCTION: Invasive pneumococcal disease is an uncommon and notifiable disease in Singapore. It is often associated with significant morbidity and mortality. We report a rare case of invasive pneumococcal bacteraemia due to parotitis in a patient with systemic sclerosis and secondary Sjögren's syndrome. We also present a retrospective review of Streptococcus pneumoniae bacteraemia cases in Singapore General Hospital from January 2011 to April 2016. CASE PRESENTATION: A 59-year-old Malay lady with a history of systemic sclerosis with secondary Sjögren's syndrome presented with fever and left parotid gland swelling...
October 2016: JMM Case Reports
https://www.readbyqxmd.com/read/28342830/patients-taking-amoxicillin-clavulanic-can-become-simultaneously-sensitized-to-both-drugs
#6
María Salas, Jose Julio Laguna, Inmaculada Doña, Esther Barrionuevo, Rubén Fernandez-Santamaría, Adriana Ariza, Ezequiel Perez-Inestrosa, Cristobalina Mayorga, Tahia Diana Fernández, María José Torres
BACKGROUND: Patients can react to amoxicillin (AX) and clavulanic acid (CLV) taken in combination because of selective reactions to either drug. However, scant information exists concerning patients who react simultaneously to both compounds. OBJECTIVE: To analyze the mechanisms involved in 4 patients who developed allergic reactions to AX-CLV administration (3 with immediate IgE-mediated reaction and 1 with nonimmediate T-cell-mediated reaction) and who responded specifically to both AX and CLV...
May 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28288165/neutropenia-induced-by-high-dose-intravenous-benzylpenicillin-in-treating-neurosyphilis-does-it-really-matter
#7
Rui-Rui Peng, Juan Wu, Wei Zhao, Tengfei Qi, Mei Shi, Zhifang Guan, Haikong Lu, Fuquan Long, Zixiao Gao, Sufang Zhang, Pingyu Zhou
BACKGROUND: Prompt therapy with high-dose intravenous benzylpenicillin for a prolonged period is critical for neurosyphilis patients to avoid irreversible sequelae. However, life-threatening neutropenia has been reported as a complication of prolonged therapy with high doses of benzylpenicillin when treating other diseases. This study aimed to investigate the incidence, presentation, management and prognosis of benzylpenicillin-induced neutropenia in treating neurosyphilis based on a large sample of syphilis patients in Shanghai...
March 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28263245/the-treatment-of-possible-severe-infection-in-infants-an-open-randomized-safety-trial-of-parenteral-benzylpenicillin-and-gentamicin-versus-ceftriaxone-in-infants-60-days-of-age-in-malawi
#8
Elizabeth M Molyneux, Queen Dube, Francis Banda, Msandeni Chiume, Isaac Singini, Macpherson Mallewa, Edward C Schwalbe, Robert S Heyderman
BACKGROUND: The World Health Organization recommends benzylpenicillin and gentamicin as antimicrobial treatment of infants with sepsis in low income settings (LICs), and ceftriaxone or cefotaxime as an alternative. In a meta-analysis from 13 LICs, Staphylococcus aureus, Klebsiella spp. and E.coli accounted for 55% of infants with sepsis. In a review of bacterial meningitis, resistance to third generation cephalosporins was >50% of all isolates, and 44% of Gram-negative isolates were gentamicin resistant...
February 28, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28235386/characteristics-of-ci-children-with-complicated-middle-ear-infections
#9
Søren Hoberg, Christian Danstrup, Bjarke Laursen, Niels Krintel Petersen, Nichlas Udholm, Gintaras Audrius Kamarauskas, Therese Ovesen
OBJECTIVE: To describe cases of complicated middle ear infections in children with cochlear implants (CI), i.e., episodes of acute otitis media (AOM) and acute mastoiditis (AM), resulting in hospitalization. METHODS: A total of 206 children under 16 years (300 implantations) were implanted between 1 January 2008 and 31 December 2014 at the West Danish CI Center, Department of Otorhinolaryngology Head and Neck Surgery, Aarhus, Denmark. By means of two prospective local databases, episodes of AOM or AM and demographics were retrieved including biochemistry, microbiology, length of follow- up, and variable treatment modalities (intravenous (IV) antibiotics, revision mastoidectomy, and insertion of ventilation tubes)...
February 24, 2017: Cochlear Implants International
https://www.readbyqxmd.com/read/28231527/rapid-discrimination-and-determination-of-antibiotics-drugs-in-plastic-syringes-using-near-infrared-spectroscopy-with-chemometric-analysis-application-to-amoxicillin-and-penicillin
#10
Laetitia Minh Mai Lê, Luc Eveleigh, Ikram Hasnaoui, Patrice Prognon, Arlette Baillet-Guffroy, Eric Caudron
The aim of this study was to investigate near infrared spectroscopy (NIRS) combined to chemometric analysis to discriminate and quantify three antibiotics by direct measurement in plastic syringes.Solutions of benzylpenicillin (PENI), amoxicillin (AMOX) and amoxicillin/clavulanic acid (AMOX/CLAV) were analyzed at therapeutic concentrations in glass vials and plastic syringes with NIR spectrometer by direct measurement. Chemometric analysis using partial least squares regression and discriminative analysis was conducted to develop qualitative and quantitative calibration models...
February 14, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28221837/environmental-occurrence-and-antibiotic-susceptibility-profile-of-listeria-monocytogenes-at-a-slaughterhouse-raw-processing-plant-in-romania
#11
Claudia Sala, Adriana Morar, Emil Tîrziu, Ileana Nichita, Mirela Imre, Kálmán Imre
This survey was conducted to investigate the occurrence and antimicrobial susceptibility of Listeria monocytogenes isolates in the environment of a pig slaughterhouse raw processing plant complex in western Romania. A total of 97 environmental samples from food contact (n = 60) and nonfood contact (n = 37) surfaces were examined with standard methods. The susceptibility of the isolates to 17 antimicrobial agents was determined with the VITEK 2 automated system. Overall, 25 (25.8%) samples were positive for L...
October 2016: Journal of Food Protection
https://www.readbyqxmd.com/read/28193743/yaws-osteoperiostitis-treated-with-single-dose-azithromycin
#12
Camila González-Beiras, Martí Vall-Mayans, Ángel González-Escalante, Kelly McClymont, Li Ma, Oriol Mitjà
AbstractThe etiologic agent of yaws, Treponema pallidum subsp. pertenue, causes a multistage infection transmitted by nonsexual contact with the exudates from active lesions. Bone lesions in the form of osteoperiostitis are common and occur in numerous bones simultaneously in early stages. Although a multinational eradication campaign with mass administration of intramuscular benzathine benzylpenicillin in the 1950s greatly reduced its global incidence, a resurgence of yaws has occurred since around 2000 in western and central Africa and the Pacific Islands...
May 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28179375/quantitative-prediction-of-human-renal-clearance-and-drug-drug-interactions-of-organic-anion-transporter-substrates-using-in-vitro-transport-data
#13
Sumathy Mathialagan, Mary A Piotrowski, David A Tess, Bo Feng, John Litchfiled, Manthena V Varma
Organic anion transporters (OATs) play an important role in the renal secretion of drugs, and their functional change can result in pharmacokinetic variability. In this study, we applied transport rates measured using OAT-transfected human embryonic kidney cells to predict human renal secretory and total renal clearance of 31 diverse drugs. Selective substrates to OAT1 (tenofovir), OAT2 (acyclovir and ganciclovir) and OAT3 (benzylpenicillin, oseltamivir acid) were used to obtain relative activity factors (RAFs) for these individual transporters by relating in vitro transport clearance to in vivo secretory clearance...
February 8, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/28159247/fabric-phase-sorptive-extraction-of-selected-penicillin-antibiotic-residues-from-intact-milk-followed-by-high-performance-liquid-chromatography-with-diode-array-detection
#14
Victoria Samanidou, Katia Michaelidou, Abuzar Kabir, Kenneth G Furton
Fabric phase sorptive extraction (FPSE), a novel sorbent-based microextraction method, was evaluated as a simple and rapid strategy for the extraction of four penicillin antibiotic residues (benzylpenicillin, cloxacillin, dicloxacillin and oxacillin) from cows' milk, without prior protein precipitation. Time-consuming solvent evaporation and reconstitution steps were eliminated successfully from the sample preparation workflow. FPSE utilizes a flexible fabric substrate, chemically coated with sol-gel derived, highly efficient, organic-inorganic hybrid sorbent as the extraction medium...
June 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28156021/loss-of-cutaneous-microbial-diversity-during-first-three-weeks-of-life-in-very-low-birth-weight-infants
#15
A Salava, V Aho, E Lybeck, P Pereira, L Paulin, I Nupponen, A Ranki, P Auvinen, S Andersson, A Lauerma
Neonatal sepsis (NS) is a frequent problem in neonatal intensive care, especially in preterm and very low birth weight (VLBW) infants. The objective of the study was to characterize the cutaneous bacterial microbiome in VLBW infants treated in the neonatal intensive care unit (NICU). Non-invasive skin microbiome specimens were taken repeatedly from 12 VLBW infants during treatment in NICU starting on the first day of life. All infants received benzylpenicillin and netilmicin during the first 1-5 postnatal days...
February 3, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28120523/prioritisation-of-pharmaceuticals-based-on-risks-to-aquatic-environments-in-kazakhstan
#16
Bakhyt Aubakirova, Raikhan Beisenova, Alistair B A Boxall
Over the last 20 years, there has been increasing interest in the occurrence, fate, effects and risk of pharmaceuticals in the natural environment. However, we still have only limited or no data on ecotoxicological risks of many of the active pharmaceutical ingredients (APIs) currently in use. This is partly due to the fact that the environmental assessment of an API is an expensive, time-consuming and complicated process. Prioritisation methodologies, that aim to identify APIs of most concern in a particular situation, could therefore be invaluable in focusing experimental work on APIs that really matter...
January 25, 2017: Integrated Environmental Assessment and Management
https://www.readbyqxmd.com/read/28069883/comparison-of-phenotypic-methods-for-the-detection-of-penicillinase-in-staphylococcus-aureus-and-proposal-of-a-practical-diagnostic-approach
#17
Michael Hombach, Christoph Weissert, Maria Magdalena Senn, Reinhard Zbinden
Objectives: Disc diffusion is a cost-efficient, low-complexity, reliable method for detection of blaZ -mediated benzylpenicillin resistance in Staphylococcus aureus if the zone edge is inspected. EUCAST breakpoints cannot fully separate β-lactamase-positive from β-lactamase-negative strains, and EUCAST recommends the zone edge test. Literature on nitrocefin-based testing and the zone edge test is scarce with wide variations in reported assay performance. Methods: This study compared two different nitrocefin-based commercial and in-house tests and the EUCAST-based zone edge test for penicillinase detection in S...
April 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28029281/pharmacokinetics-of-intravenous-continuous-rate-infusions-of-sodium-benzylpenicillin-and-ceftiofur-sodium-in-adult-horses
#18
RANDOMIZED CONTROLLED TRIAL
Scott H Edwards, Shahid A Khalfan, Glenn A Jacobson, Adam D Pirie, Sharanne L Raidal
OBJECTIVE To determine plasma drug concentrations after IV administration of a bolus followed by continuous rate infusion (CRI) of sodium benzylpenicillin and ceftiofur sodium to healthy adult horses. ANIMALS 6 Thoroughbred mares (3 to 9 years old; mean ± SD body weight, 544 ± 55 kg) with no history of recent antimicrobial treatment. PROCEDURES Horses were used in 2 experiments conducted 14 days apart. For each experiment, horses were housed individually in stables, and catheters were placed bilaterally in both jugular veins for drug administration by CRI (left catheter) and for intermittent collection of blood samples (right catheter)...
January 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28018077/hip-adductor-pyomyositis-from-streptococcus-mitis-in-a-four-year-old-child
#19
Metin Tolga Buldu, Raghu Raman
The unique aspect of this case study is the unusual history, presentation, ultrasonography, MRI and blood culture results, which lead to the diagnosis and treatment of adductor pyomyositis with a rare organism in a temperate country. The patient presented with a one-day history of malaise, fever, left groin pain and inability to weight bear on the left leg. There was no history of any trauma, predisposing infections or recent travel. Plain radiograph and ultrasound of the hip was normal with no effusion. Two consecutive blood cultures suggested Streptococcus mitis bacteraemia and MRI scan confirmed pyomyositis of the left hip adductors that was too small to drain...
October 2016: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/27989096/abiotrophia-defectiva-endocarditis-complicated-by-ventricular-tachycardia
#20
Kyriacos Mouyis, Sophia Metaxa, Constantinos Missouris
A 78-year-old man was admitted to the authors' hospital with a short history of shortness of breath and pyrexia. He had long-standing moderate mitral regurgitation and stable coronary artery disease. Blood cultures grew Abiotrophia defectiva coccobaccili. Transesophageal echocardiography confirmed the diagnosis of mitral valve endocarditis that necessitated treatment with intravenous benzylpenicillin and gentamicin for six weeks. At nine days after admission the patient developed several episodes of self-limiting monomorphic ventricular tachycardia, without ischemic cardiac pain, associated with hemodynamic compromise requiring treatment with intravenous amiodarone and inotropic support in the Intensive Care Unit...
January 2016: Journal of Heart Valve Disease
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