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prognostic biomarker bladder

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https://www.readbyqxmd.com/read/29896971/circulating-mirnas-in-blood-and-urine-as-diagnostic-and-prognostic-biomarkers-for-bladder-cancer-an-update-in-2017
#1
Angelika Tölle, Conrad C Blobel, Klaus Jung
This study presents a critical appraisal of previously published study data of miRNAs in blood, urine and exosomes as biomarkers of bladder cancer (BC). The evaluation included 39 articles published from the beginning of 2010 until September 2017 and searched in PubMed. The heterogeneity of studies, due to their clinicopathological variability, including insufficient consideration of diagnostic and prognostic biomarker guidelines and missing internal and external validation of data, do not currently allow the recommending of a useful miRNA marker as diagnostic or prognostic tool in BC...
June 13, 2018: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29879970/prognostic-significance-of-epidermal-growth-factor-receptor-egfr-over-expression-in-urothelial-carcinoma-of-urinary-bladder
#2
Atif Ali Hashmi, Zubaida Fida Hussain, Muhammad Irfan, Erum Yousuf Khan, Naveen Faridi, Hanna Naqvi, Amir Khan, Muhammad Muzzammil Edhi
BACKGROUND: Epidermal growth factor receptor (EGFR) has been shown to have abnormal expression in many human cancers and is considered as a marker of poor prognosis. Frequency of over expression in bladder cancer has not been studied in our population; therefore we aimed to evaluate the frequency and prognostic significance of EGFR immunohistochemical expression in locoregional population. METHODS: We performed EGFR immunohistochemistry on 126 cases of bladder cancer and association of EGFR expression with tumor grade, lamina propria invasion, deep muscle invasion and recurrence of disease was evaluated...
June 7, 2018: BMC Urology
https://www.readbyqxmd.com/read/29870555/the-prognostic-significance-of-long-noncoding-rnas-in-bladder-cancer-a-meta-analysis
#3
Yuexin Xia, Zhiyuan Liu, Weijian Yu, Shihang Zhou, Linnan Shao, Wenqian Song, Ming Liu
INTRODUCTION: Bladder cancer (BC) is one of the most common urologic malignancies and it is urgently needed to identify novel potential prognostic biomarkers for predicting prognosis and progression of patients with BC in clinical practice. Previous research has revealed that long noncoding RNAs (lncRNAs) played critical roles in BC, and may serve as novel potential prognostic biomarkers in patients with BC. Therefore, we conducted this meta-analysis to clarify the prognostic potential of lncRNAs in BC patients...
2018: PloS One
https://www.readbyqxmd.com/read/29865039/high-expression-of-spindle-and-kinetochore-associated-protein-1-predicts-early-recurrence-and-progression-of-non-muscle-invasive-bladder-cancer
#4
Sixiong Jiang, Feng Tian, Qi Wang, Wen Cheng, Longxin Wang, Ying Wang, Weibing Sun
BACKGROUND: Spindle and kinetochore-associated protein 1 (SKA1) is a component of SKA, which is essential for proper chromosome segregation. Recently, SKA1 was found to be over-expressed in several types of human cancers. However, reports on the relationship between SKA1 expression and the prognosis of bladder cancer, in particular, are lacking. OBJECTIVES: To clarify the clinical significance of SKA1 as a prognostic biomarker for early recurrence and progression of patients with non-muscle invasive bladder cancer (NMIBC)...
May 25, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29863247/evaluation-of-the-prognostic-value-of-lmr-plr-nlr-and-dnlr-in-urothelial-bladder-cancer-patients-treated-with-radical-cystectomy
#5
P Rajwa, M Życzkowski, A Paradysz, K Bujak, P Bryniarski
OBJECTIVE: Our aim was to evaluate the association between preoperative LMR, PLR, NLR, dNLR, and survival of urothelial bladder cancer (UBC) patients treated with radical cystectomy (RC). We also analyzed the relationship between preoperative blood-based inflammatory biomarkers' levels and postoperative in-hospital complications. PATIENTS AND METHODS: This retrospective study included 144 UBC patients, who underwent RC between 2003 and 2015. The study endpoints were cancer-specific survival (CSS) and overall survival (OS)...
May 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29861867/exploring-the-roles-of-urinary-hai-1-epcam-egfr-in-bladder-cancer-prognosis-risk-stratification
#6
Kym I E Snell, Douglas G Ward, Naheema S Gordon, James C Goldsmith, Andrew J Sutton, Prashant Patel, Nicholas D James, Maurice P Zeegers, K K Cheng, Richard T Bryan
Objectives: To investigate whether elevated urinary HAI-1, EpCAM and EGFR are independent prognostic biomarkers within non-muscle-invasive bladder cancer (NMIBC) patients, and have utility for risk stratification to facilitate treatment decisions. Results: After accounting for EAU risk group in NMIBC patients, the risk of BC-specific death was 2.14 times higher (95% CI: 1.08 to 4.24) if HAI-1 was elevated and 2.04 times higher (95% CI: 1.02 to 4.07) if EpCAM was elevated...
May 18, 2018: Oncotarget
https://www.readbyqxmd.com/read/29860035/prognostic-value-of-dna-methylation-for-bladder-cancer
#7
REVIEW
Yinghui Yu, Hui Cao, Mengmeng Zhang, Fang Shi, Rui Wang, Xin Liu
PURPOSE: A growing number of researches manifest that DNA methylation has been considered as biomarker for the prognosis of bladder cancer (BC). However, the results are still in a discrepancy. MATERIALS AND METHODS: This meta-analysis was conducted in accordance with PRISMA guidelines. Studies evaluating the practicability of methylated DNA as a prognostic marker for BC were thoroughly searched via the PubMed, Web of science and the Cochrane Library databases from January 1st, 2000 to May 5th, 2018...
June 1, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29857476/diagnostic-and-prognostic-potential-of-microrna-maturation-regulators-drosha-ago1-and-ago2-in-urothelial-carcinomas-of-the-bladder
#8
Anja Rabien, Nadine Ratert, Anica Högner, Andreas Erbersdobler, Klaus Jung, Thorsten H Ecke, Ergin Kilic
Bladder cancer still requires improvements in diagnosis and prognosis, because many of the cases will recur and/or metastasize with bad outcomes. Despite ongoing research on bladder biomarkers, the clinicopathological impact and diagnostic function of miRNA maturation regulators Drosha and Argonaute proteins AGO1 and AGO2 in urothelial bladder carcinoma remain unclear. Therefore, we conducted immunohistochemical investigations of a tissue microarray composed of 112 urothelial bladder carcinomas from therapy-naïve patients who underwent radical cystectomy or transurethral resection and compared the staining signal with adjacent normal bladder tissue...
May 31, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29762827/upregulation-of-long-non-coding-rna-hnf1a-as1-is-associated-with-poor-prognosis-in-urothelial-carcinoma-of-the-bladder
#9
Y-H Wang, Y-H Liu, Y-J Ji, Q Wei, T-B Gao
OBJECTIVE: Long noncoding RNAs (lncRNAs) play important roles in the pathogenesis of bladder cancer. A recent study reported that lncRNA HNF1A-AS1 (HNF1A-AS1) was upregulated in urothelial carcinoma of the bladder (UCB) and served as a tumor promoter. However, the clinical significance of HNF1A-AS1 in the prognosis of patients with UCB was poorly understood. This work was designed to investigate the relationship between HNF1A-AS1 expression level and the prognosis of UCB. PATIENTS AND METHODS: Relative expression levels of HNF1A-AS1 in UCB tissues were determined by qRT-PCR...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29744554/-current-and-established-diagnostic-modalities-for-bladder-cancer
#10
REVIEW
D Zaak, C Ohlmann, A Stenzl
INTRODUCTION: In this paper, current guidelines regarding diagnostic and staging modalities of urothelial cancer of the bladder are summarized and an overview of endoscopic, imaging, and molecular methods currently being tested are outlined. METHODS: Relevant passages from current guidelines and recent literature as well as to a certain extent our own research are examined. RESULTS: Over the last decade, imaging mainly in the form of photodynamic diagnosis (PDD) has undergone further development and found its way into several guidelines...
May 9, 2018: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/29737231/progressive-tissue-biomarker-profiling-in-non-muscle-invasive-bladder-cancer
#11
David D'Andrea, Melanie R Hassler, Mohammad Abufaraj, Francesco Soria, Iris E Ertl, Dafina Ilijazi, Andrea Mari, Beat Foerster, Gerda Egger, Shahrokh F Shariat
The recurrence rate of non-muscle-invasive bladder cancer (NMIBC) is up to 60% within the first year of therapy. Accurate risk stratification is necessary for patient counselling, follow-up scheduling and individualized therapeutic decision making. Current prognostic models rely on clinicopathologic features, but their discrimination remains limited when in external cohorts. Despite intense efforts regarding the value of biomarkers in prognosticating outcomes in NMIBC, clinical utility remains suboptimal. It is clear that a single biomarker is not enough for the prediction of disease recurrence...
July 2018: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/29725414/upregulated-gaplinc-predicts-a-poor-prognosis-in-bladder-cancer-patients-and-promotes-tumor-proliferation-and-invasion
#12
Zaosong Zheng, Dingjun Zhu, Fengjin Zhao, Jinli Han, Haicheng Chen, Yuhong Cai, Wenlian Xie
Previous studies have demonstrated that long noncoding RNAs (lncRNAs) exhibit critical regulatory roles in cancer biology. However, few lncRNAs have been well characterized in bladder cancer. In the previous study, we demonstrated that gastric adenocarcinoma associated, positive CD44 regulator, long intergenic noncoding RNA (GAPLINC) was significantly upregulated in bladder cancer tissues compared with normal tissues in The Cancer Genome Atlas (TCGA) cohort (P=0.039) and a validated cohort of 80 patients with bladder cancer (P=0...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29719631/preoperative-hemoglobin-platelet-ratio-can-significantly-predict-progression-and-mortality-outcomes-in-patients-with-t1g3-bladder-cancer-undergoing-transurethral-resection-of-bladder-tumor
#13
Gang Tang, Yunpeng Zhen, Wanqin Xie, Yinlei Wang, Feiran Chen, Chuan Qin, Han Yang, Zhiyong Du, Zhonghua Shen, Bo Zhang, Zhouliang Wu, Dawei Tian, Hailong Hu
Objective: To investigate the prognostic role of hematological biomarkers, especially hemoglobin-platelet ratio (HPR) in the oncological outcomes in stage 1 and grade 3 (T1G3) bladder cancer. Materials and Methods: We identified 457 T1G3 bladder cancer patients who underwent transurethral resection of the bladder (TURB) between 2009 and 2014. Based on hematological parameters (hemoglobin-platelet ratio (HPR), hemoglobin, and platelet counts), recurrence-free survival (RFS), progression-free survival (PFS), and overall survival (OS) and cancer-specific survival (CSS) were analyzed by using Kaplan-Meier analysis...
April 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29719336/study-of-proliferating-cell-nuclear-antigen-expression-and-angiogenesis-in-urothelial-neoplasms-correlation-with-tumor-grade-and-stage
#14
Poojan Agarwal, Achin Kumar Sen, Minakshi Bhardwaj, Veronique Dinand, Arvind Ahuja, Rajeev Sood
Background: Urinary bladder carcinoma ranks ninth in worldwide cancer incidence. About 74,000 new cases were diagnosed in 2015 alone and 16,000 persons died of the disease. Since histopathology is considered gold standard for diagnosis, it is prudent to look for potential tumor proliferation and predictive markers in such a prevalent malignancy so as to alert surgical and medical oncologists for timely intervention and provide better patient-tailored therapy. Aims: This study is to analyze the role of potential biomarkers-proliferating cell nuclear antigen (PCNA) and angiogenesis using CD31 in urothelial neoplasms in relation to tumor grade and stage...
April 2018: Urology Annals
https://www.readbyqxmd.com/read/29707153/diagnostic-and-prognostic-biomarker-potential-of-kallikrein-family-genes-in-different-cancer-types
#15
Prashant D Tailor, Sai Karthik Kodeboyina, Shan Bai, Nikhil Patel, Shruti Sharma, Akshay Ratnani, John A Copland, Jin-Xiong She, Ashok Sharma
Purpose: The aim of this study was to compare and contrast the expression of all members of the Kallikrein (KLK) family of genes across 15 cancer types and to evaluate their utility as diagnostic and prognostic biomarkers. Results: Severe alterations were found in the expression of different Kallikrein genes across various cancers. Interestingly, renal clear cell and papillary carcinomas have similar kallikrein expression profiles, whereas, chromophobe renal cell carcinoma has a unique expression profile...
April 3, 2018: Oncotarget
https://www.readbyqxmd.com/read/29695915/expression-of-pyruvate-kinase-m2-in-human-bladder-cancer-and-its-correlation-with-clinical-parameters-and-prognosis
#16
Changkun Huang, Zhichao Huang, Peiming Bai, Guangcheng Luo, Xiaokun Zhao, Xinjun Wang
Background: Pyruvate kinase M2 (PKM2) is a key regulator of the Warburg effect and has critical functions in glycolysis, contributing to the Warburg effect, tumor growth, angiogenesis, cell division, metastasis, and apoptosis. The high expression of PKM2 in various solid tumors renders it a potential biomarker of tumorigenesis and tumor invasion, but the expression and role of PKM2 in bladder cancer have not been studied extensively. Patients and methods: Western blot and immunohistochemistry (IHC) were used to measure the expression of PKM2, and quantitative real-time polymerase chain reaction (PCR) was performed to determine PKM2 mRNA levels...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29682192/-atm-rb1-mutations-predict-shorter-overall-survival-in-urothelial-cancer
#17
Ming Yin, Petros Grivas, Hamid Emamekhoo, Prateek Mendiratta, Siraj Ali, JoAnn Hsu, Monali Vasekar, Joseph J Drabick, Sumanta Pal, Monika Joshi
Background: Mutations of DNA repair genes, e.g. ATM/RB1 , are frequently found in urothelial cancer (UC) and have been associated with better response to cisplatin-based chemotherapy. Further external validation of the prognostic value of ATM/RB1 mutations in UC can inform clinical decision making and trial designs. Results: In the discovery dataset, ATM/RB1 mutations were present in 24% of patients and were associated with shorter OS (adjusted HR 2.67, 95% CI, 1...
March 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29662611/gpx2-promotes-development-of-bladder-cancer-with-squamous-cell-differentiation-through-the-control-of-apoptosis
#18
Taku Naiki, Aya Naiki-Ito, Keitaro Iida, Toshiki Etani, Hiroyuki Kato, Shugo Suzuki, Yoriko Yamashita, Noriyasu Kawai, Takahiro Yasui, Satoru Takahashi
Herein, we elucidated the molecular mechanisms and therapeutic potential of glutathione peroxidase 2 (GPX2) in bladder cancer. GPX2 expression gradually increased during progression from normal to papillary or nodular hyperplasia (PNHP) and urothelial carcinoma (UC) in a rat N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN)-induced bladder carcinogenesis model. GPX2 overexpression was more marked in UC with squamous differentiation (SqD) than in pure UC. Clinical intraepithelial lesions of papillary UC and invasive UC with SqD also had strong GPX2 expression in human radical cystectomy specimens...
March 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29644173/identification-of-hypoxic-gene-signature-as-a-prognostic-and-predictive-biomarker-to-determine-effective-therapy-in-high-risk-bladder-cancer-patients
#19
EDITORIAL
Zheng Tan, Ninadh M D'Costa, Peter A Raven, Claudia Chavez-Munoz, Alan I So
No abstract text is available yet for this article.
March 2018: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29620229/mir%C3%A2-22%C3%A2-3p-enhances-multi%C3%A2-chemoresistance-by-targeting-net1-in-bladder-cancer-cells
#20
Jun Xiao, Sanqiang Niu, Jiahong Zhu, Lei Lv, Hui Deng, Daqing Pan, Deyun Shen, Congyun Xu, Zhou Shen, Tao Tao
With the discovery of new chemotherapeutic drugs, chemotherapy becomes increasingly valuable. However, the resistance of tumor cells to chemotherapeutic agents significantly limits the effectiveness and causes chemotherapy failure. MicroRNAs have been shown to regulate drug resistance in many types of cancer. In the present study, we measured the chemosensitivity of five bladder cancer (BCa) cell lines to seven commonly used chemotherapeutic drugs by Vita‑Blue assay. We then identified the most sensitive (5637) and most tolerant cell lines (H‑bc) and conducted a multi‑group test...
June 2018: Oncology Reports
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