Tong Zhang, Han Lv, Xinyu Zhao, Na Zeng, Ying Hui, Shuohua Chen, Ning Wu, Mingze Xu, YunTao Wu, Aijun Xing, Huijing Shi, Shun Zhang, Xiaoliang Liang, Yongxin Wang, Shouling Wu, Liufu Cui, Zhenchang Wang, Yanying Liu
BACKGROUND: Serum uric acid (SUA) is a major cause of cardiovascular and cerebrovascular diseases. Whether and to what extent the excess risk of enlarged perivascular spaces (EPVS) conferred by SUA is unknown. The study was conducted to investigate the association between SUA and EPVS in different brain regions. METHODS: Data are from Multi-modality medical imaging study based on Kailuan study (META-KLS) in this cross-sectional study. Participants were divided into five groups based on SUA levels, and EPVS in basal ganglia (BG), centrum semiovale (CSO) and midbrain (MB) was systematically assessed and divided into Low and High group...
April 3, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry