keyword
MENU ▼
Read by QxMD icon Read
search

Imaging in Psychiatry

keyword
https://www.readbyqxmd.com/read/29133954/exogenous-ghrelin-administration-increases-alcohol-self-administration-and-modulates-brain-functional-activity-in-heavy-drinking-alcohol-dependent-individuals
#1
M Farokhnia, E N Grodin, M R Lee, E N Oot, A N Blackburn, B L Stangl, M L Schwandt, L A Farinelli, R Momenan, V A Ramchandani, L Leggio
Preclinical evidence suggests that ghrelin, a peptide synthesized by endocrine cells of the stomach and a key component of the gut-brain axis, is involved in alcohol seeking as it modulates both central reward and stress pathways. However, whether and how ghrelin administration may impact alcohol intake in humans is not clear. For, we believe, the first time, this was investigated in the present randomized, crossover, double-blind, placebo-controlled, human laboratory study. Participants were non-treatment-seeking alcohol-dependent heavy-drinking individuals...
November 14, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/29133948/increased-hippocampal-tail-volume-predicts-depression-status-and-remission-to-anti-depressant-medications-in-major-depression
#2
J J Maller, K Broadhouse, A J Rush, E Gordon, S Koslow, S M Grieve
Studies of patients with major depressive disorder (MDD) have consistently reported reduced hippocampal volumes; however, the exact pattern of these volume changes in specific anatomical subfields and their functional significance is unclear. We sought to clarify the relationship between hippocampal tail volumes and (i) a diagnosis of MDD, and (ii) clinical remission to anti-depressant medications (ADMs). Outpatients with nonpsychotic MDD (n=202) based on DSM-IV criteria and a 17-item Hamilton Rating Scale for Depression (HRSD17) score ⩾16 underwent pretreatment magnetic resonance imaging as part of the international Study to Predict Optimized Treatment for Depression (iSPOT-D)...
November 14, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/29112191/identifying-specific-prefrontal-neurons-that-contribute-to-autism-associated-abnormalities-in-physiology-and-social-behavior
#3
A C Brumback, I T Ellwood, C Kjaerby, J Iafrati, S Robinson, A T Lee, T Patel, S Nagaraj, F Davatolhagh, V S Sohal
Functional imaging and gene expression studies both implicate the medial prefrontal cortex (mPFC), particularly deep-layer projection neurons, as a potential locus for autism pathology. Here, we explored how specific deep-layer prefrontal neurons contribute to abnormal physiology and behavior in mouse models of autism. First, we find that across three etiologically distinct models-in utero valproic acid (VPA) exposure, CNTNAP2 knockout and FMR1 knockout-layer 5 subcortically projecting (SC) neurons consistently exhibit reduced input resistance and action potential firing...
November 7, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/29038599/widespread-white-matter-microstructural-differences-in-schizophrenia-across-4322-individuals-results-from-the-enigma-schizophrenia-dti-working-group
#4
S Kelly, N Jahanshad, A Zalesky, P Kochunov, I Agartz, C Alloza, O A Andreassen, C Arango, N Banaj, S Bouix, C A Bousman, R M Brouwer, J Bruggemann, J Bustillo, W Cahn, V Calhoun, D Cannon, V Carr, S Catts, J Chen, J-X Chen, X Chen, C Chiapponi, Kl K Cho, V Ciullo, A S Corvin, B Crespo-Facorro, V Cropley, P De Rossi, C M Diaz-Caneja, E W Dickie, S Ehrlich, F-M Fan, J Faskowitz, H Fatouros-Bergman, L Flyckt, J M Ford, J-P Fouche, M Fukunaga, M Gill, D C Glahn, R Gollub, E D Goudzwaard, H Guo, R E Gur, R C Gur, T P Gurholt, R Hashimoto, S N Hatton, F A Henskens, D P Hibar, I B Hickie, L E Hong, J Horacek, F M Howells, H E Hulshoff Pol, C L Hyde, D Isaev, A Jablensky, P R Jansen, J Janssen, E G Jönsson, L A Jung, R S Kahn, Z Kikinis, K Liu, P Klauser, C Knöchel, M Kubicki, J Lagopoulos, C Langen, S Lawrie, R K Lenroot, K O Lim, C Lopez-Jaramillo, A Lyall, V Magnotta, R C W Mandl, D H Mathalon, R W McCarley, S McCarthy-Jones, C McDonald, S McEwen, A McIntosh, T Melicher, R I Mesholam-Gately, P T Michie, B Mowry, B A Mueller, D T Newell, P O'Donnell, V Oertel-Knöchel, L Oestreich, S A Paciga, C Pantelis, O Pasternak, G Pearlson, G R Pellicano, A Pereira, J Pineda Zapata, F Piras, S G Potkin, A Preda, P E Rasser, D R Roalf, R Roiz, A Roos, D Rotenberg, T D Satterthwaite, P Savadjiev, U Schall, R J Scott, M L Seal, L J Seidman, C Shannon Weickert, C D Whelan, M E Shenton, J S Kwon, G Spalletta, F Spaniel, E Sprooten, M Stäblein, D J Stein, S Sundram, Y Tan, S Tan, S Tang, H S Temmingh, L T Westlye, S Tønnesen, D Tordesillas-Gutierrez, N T Doan, J Vaidya, N E M van Haren, C D Vargas, D Vecchio, D Velakoulis, A Voineskos, J Q Voyvodic, Z Wang, P Wan, D Wei, T W Weickert, H Whalley, T White, T J Whitford, J D Wojcik, H Xiang, Z Xie, H Yamamori, F Yang, N Yao, G Zhang, J Zhao, T G M van Erp, J Turner, P M Thompson, G Donohoe
The regional distribution of white matter (WM) abnormalities in schizophrenia remains poorly understood, and reported disease effects on the brain vary widely between studies. In an effort to identify commonalities across studies, we perform what we believe is the first ever large-scale coordinated study of WM microstructural differences in schizophrenia. Our analysis consisted of 2359 healthy controls and 1963 schizophrenia patients from 29 independent international studies; we harmonized the processing and statistical analyses of diffusion tensor imaging (DTI) data across sites and meta-analyzed effects across studies...
October 17, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/29030624/psilocybin-for-treatment-resistant-depression-fmri-measured-brain-mechanisms
#5
Robin L Carhart-Harris, Leor Roseman, Mark Bolstridge, Lysia Demetriou, J Nienke Pannekoek, Matthew B Wall, Mark Tanner, Mendel Kaelen, John McGonigle, Kevin Murphy, Robert Leech, H Valerie Curran, David J Nutt
Psilocybin with psychological support is showing promise as a treatment model in psychiatry but its therapeutic mechanisms are poorly understood. Here, cerebral blood flow (CBF) and blood oxygen-level dependent (BOLD) resting-state functional connectivity (RSFC) were measured with functional magnetic resonance imaging (fMRI) before and after treatment with psilocybin (serotonin agonist) for treatment-resistant depression (TRD). Quality pre and post treatment fMRI data were collected from 16 of 19 patients. Decreased depressive symptoms were observed in all 19 patients at 1-week post-treatment and 47% met criteria for response at 5 weeks...
October 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29019460/auditory-hallucinations-as-translational-psychiatry-evidence-from-magnetic-resonance-imaging
#6
Kenneth Hugdahl
In this invited review article I present a translational perspective and overview of our research on auditory hallucinations in schizophrenia at the University of Bergen, Norway with a focus on the neuronal mechanisms underlying the phenomenology of experiencing "hearing voices". An auditory verbal hallucination, i.e. "hearing a voice", is defined as a sensory experience in the absence of a corresponding external sensory source that could explain the phenomenological experience. I suggest a general frame or scheme for the study of auditory verbal hallucinations which is called Levels of Explanation (LoE)...
October 11, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28994478/treatment-of-developmental-stress-disorder-mind-body-and-brain-analysis-and-pharmacology-coupled
#7
Joseph McFadden
The schism between psychiatry, psychology and analysis, while long present, has widened even more in the past half-century with the advances in psychopharmacology. With the advances in electronic brain imaging, particularly in developmental and post-traumatic stress disorders, there has emerged both an understanding of brain changes resulting from severe, chronic stress and an ability to target brain chemistry in ways that can relieve clinical symptomatology. The use of alpha-1 adrenergic brain receptor antagonists decreases many of the manifestations of PTSD...
November 2017: Journal of Analytical Psychology
https://www.readbyqxmd.com/read/28962844/neuroimaging-in-psychiatry-steps-toward-the-clinical-application-of-brain-imaging-in-psychiatric-disorders
#8
EDITORIAL
Eunsoo Won, Yong-Ku Kim
No abstract text is available yet for this article.
January 3, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28924188/dopamine-d1-receptor-subtype-mediates-acute-stress-induced-dendritic-growth-in-excitatory-neurons-of-the-medial-prefrontal-cortex-and-contributes-to-suppression-of-stress-susceptibility-in-mice
#9
R Shinohara, M Taniguchi, A T Ehrlich, K Yokogawa, Y Deguchi, Y Cherasse, M Lazarus, Y Urade, A Ogawa, S Kitaoka, A Sawa, S Narumiya, T Furuyashiki
Dopamine in prefrontal cortices is implicated in cognitive and emotional functions, and the dysfunction of prefrontal dopamine has been associated with cognitive and emotional deficits in mental illnesses. These findings have led to clinical trials of dopamine-targeting drugs and brain imaging of dopamine receptors in patients with mental illnesses. Rodent studies have suggested that dopaminergic pathway projecting to the medial prefrontal cortex (mPFC) suppresses stress susceptibility. Although various types of mPFC neurons express several dopamine receptor subtypes, previous studies neither isolated a role of dopamine receptor subtype nor identified the site of its action in mPFC...
September 19, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28924181/common-and-dissociable-regional-cerebral-blood-flow-differences-associate-with-dimensions-of-psychopathology-across-categorical-diagnoses
#10
A N Kaczkurkin, T M Moore, M E Calkins, R Ciric, J A Detre, M A Elliott, E B Foa, A Garcia de la Garza, D R Roalf, A Rosen, K Ruparel, R T Shinohara, C H Xia, D H Wolf, R E Gur, R C Gur, T D Satterthwaite
The high comorbidity among neuropsychiatric disorders suggests a possible common neurobiological phenotype. Resting-state regional cerebral blood flow (CBF) can be measured noninvasively with magnetic resonance imaging (MRI) and abnormalities in regional CBF are present in many neuropsychiatric disorders. Regional CBF may also provide a useful biological marker across different types of psychopathology. To investigate CBF changes common across psychiatric disorders, we capitalized upon a sample of 1042 youths (ages 11-23 years) who completed cross-sectional imaging as part of the Philadelphia Neurodevelopmental Cohort...
September 19, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28914403/self-transformation-at-the-boundary-of-religious-conversion-and-psychosis
#11
Szabolcs Kéri
The relationship between religious conversion, as a form of spiritual emergency, and psychosis is one of the fundamental issues at the meeting point of theology and clinical psychology. In the present study, we assessed 53 individuals referred to a psychiatry center with the initial diagnosis of a psychotic episode by focusing on the clinical diagnosis (psychosis vs. spiritual emergency), subjective experiences (basic symptoms), and neuropsychological functions. Twenty-nine individuals meet the diagnosis of schizophrenia-spectrum disorders, but 24 persons experienced only religious and spiritual problems (religious conversion)...
September 15, 2017: Journal of Religion and Health
https://www.readbyqxmd.com/read/28910997/paediatric-nuclear-medicine-imaging
#12
Lorenzo Biassoni, Marina Easty
Background: Nuclear medicine imaging explores tissue viability and function by using radiotracers that are taken up at cellular level with different mechanism. This imaging technique can also be used to assess blood flow and transit through tubular organs. Nuclear medicine imaging has been used in paediatrics for decades and this field is continuously evolving. Sources of data: The data presented comes from clinical experience and some milestone papers on the subject...
September 1, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/28894304/quantification-of-brain-cholinergic-denervation-in-alzheimer-s-disease-using-pet-imaging-with-18-f-feobv
#13
M Aghourian, C Legault-Denis, J-P Soucy, P Rosa-Neto, S Gauthier, A Kostikov, P Gravel, M-A Bédard
(18)F-fluoroethoxybenzovesamicol (FEOBV) is a new PET radiotracer that binds to the vesicular acetylcholine transporter. In both animals and healthy humans, FEOBV was found sensitive and reliable to characterize presynaptic cholinergic nerve terminals in the brain. It has been used here for we believe the first time in patients with Alzheimer's disease (AD) to quantify brain cholinergic losses. The sample included 12 participants evenly divided in healthy subjects and patients with AD, all assessed with the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) cognitive scales...
September 12, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28894300/striatal-dopamine-d1-type-receptor-availability-no-difference-from-control-but-association-with-cortical-thickness-in-methamphetamine-users
#14
K Okita, A M Morales, A C Dean, M C Johnson, V Lu, J Farahi, M A Mandelkern, E D London
Chronic methamphetamine use poses potentially devastating consequences for directly affected individuals and for society. Lower dopamine D2-type receptor availability has been observed in striata of methamphetamine users as compared with controls, but an analogous comparison of D1-type receptors has been conducted only on post-mortem material, with no differences in methamphetamine users from controls in the caudate nucleus and putamen and higher D1-receptor density in the nucleus accumbens. Released from neurons when methamphetamine is self-administered, dopamine binds to both D1- and D2-type receptors in the striatum, with downstream effects on cortical activity...
September 12, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28877513/predicting-functional-neuroanatomical-maps-from-fusing-brain-networks-with-genetic-information
#15
Florian Ganglberger, Joanna Kaczanowska, Josef M Penninger, Andreas Hess, Katja Bühler, Wulf Haubensak
Functional neuroanatomical maps provide a mesoscale reference framework for studies from molecular to systems neuroscience and psychiatry. The underlying structure-function relationships are typically derived from functional manipulations or imaging approaches. Although highly informative, these are experimentally costly. The increasing amount of publicly available brain and genetic data offers a rich source that could be mined to address this problem computationally. Here, we developed an algorithm that fuses gene expression and connectivity data with functional genetic meta data and exploits cumulative effects to derive neuroanatomical maps related to multi-genic functions...
September 4, 2017: NeuroImage
https://www.readbyqxmd.com/read/28877317/association-of-white-matter-structure-with-autism-spectrum-disorder-and-attention-deficit-hyperactivity-disorder
#16
Yuta Aoki, Yuliya N Yoncheva, Bosi Chen, Tanmay Nath, Dillon Sharp, Mariana Lazar, Pablo Velasco, Michael P Milham, Adriana Di Martino
Importance: Clinical overlap between autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) is increasingly appreciated, but the underlying brain mechanisms remain unknown to date. Objective: To examine associations between white matter organization and 2 commonly co-occurring neurodevelopmental conditions, ASD and ADHD, through both categorical and dimensional approaches. Design, Setting, and Participants: This investigation was a cross-sectional diffusion tensor imaging (DTI) study at an outpatient academic clinical and research center, the Department of Child and Adolescent Psychiatry at New York University Langone Medical Center...
November 1, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28870688/-what-do-virtual-reality-tools-bring-to-child-and-adolescent-psychiatry
#17
S Bioulac, E de Sevin, P Sagaspe, A Claret, P Philip, J A Micoulaud-Franchi, M P Bouvard
Virtual reality is a relatively new technology that enables individuals to immerse themselves in a virtual world. It offers several advantages including a more realistic, lifelike environment that may allow subjects to "forget" they are being assessed, allow a better participation and an increased generalization of learning. Moreover, the virtual reality system can provide multimodal stimuli, such as visual and auditory stimuli, and can also be used to evaluate the patient's multimodal integration and to aid rehabilitation of cognitive abilities...
September 1, 2017: L'Encéphale
https://www.readbyqxmd.com/read/28859565/neuroplasticity-and-the-brain-connectome-what-can-jean-talairach-s-reflections-bring-to-modern-psychosurgery
#18
Pierre Bourdillon, Caroline Apra, Marc Lévêque, Fabien Vinckier
Contrary to common psychosurgical practice in the 1950s, Dr. Jean Talairach had the intuition, based on clinical experience, that the brain connectome and neuroplasticity had a role to play in psychosurgery. Due to the remarkable progress of pharmacology at that time and to the technical limits of neurosurgery, these concepts were not put into practice. Currently, these concepts are being confirmed by modern techniques such as neuroimaging and computational neurosciences, and could pave the way for therapeutic innovation in psychiatry...
September 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28829051/dopamine-transporter-and-reward-anticipation-in-a-dimensional-perspective-a-multimodal-brain-imaging-study
#19
Manon Dubol, Christian Trichard, Claire Leroy, Anca-Larisa Sandu, Mehdi Rahim, Bernard Granger, Eleni T Tzavara, Laurent Karila, Jean-Luc Martinot, Eric Artiges
Dopamine function and reward processing are highly interrelated and involve common brain regions afferent to the Nucleus Accumbens, within the mesolimbic pathway. While dopamine function and reward system neural activity are impaired in most psychiatric disorders, it is unknown if alterations in the dopamine system underlie variations in reward processing across a continuum encompassing health and these disorders. We explored the relationship between dopamine function and neural activity during reward anticipation in twenty-seven participants including healthy volunteers and psychiatric patients with schizophrenia, depression or cocaine addiction, using functional Magnetic Resonance Imaging (fMRI) and Positron Emission Tomography (PET) multimodal imaging with a voxel-based statistical approach...
August 22, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28761082/selective-activation-of-parvalbumin-interneurons-prevents-stress-induced-synapse-loss-and-perceptual-defects
#20
C-C Chen, J Lu, R Yang, J B Ding, Y Zuo
Stress, a prevalent experience in modern society, is a major risk factor for many psychiatric disorders. Although sensorimotor abnormalities are often present in these disorders, little is known about how stress affects the sensory cortex. Combining behavioral analyses with in vivo synaptic imaging, we show that stressful experiences lead to progressive, clustered loss of dendritic spines along the apical dendrites of layer (L) 5 pyramidal neurons (PNs) in the mouse barrel cortex, and such spine loss closely associates with deteriorated performance in a whisker-dependent texture discrimination task...
August 1, 2017: Molecular Psychiatry
keyword
keyword
7314
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"