keyword
https://read.qxmd.com/read/38522353/current-management-of-carotid-body-tumors
#21
REVIEW
Hiroyuki Ozawa
Carotid body tumors (CBTs) are neoplasms that occur at the bifurcation of the carotid artery and are pathologically classified as paragangliomas. In the 4th edition of the WHO classification, paragangliomas are categorized as neoplasms with malignant potential. Clinically, about 5% of CBTs present with malignant features such as metastasis. Currently, it is challenging to distinguish between tumors with benign courses and those that present malignantly. Recent advances in genetic testing have elucidated the genetic characteristics of paragangliomas, including carotid body tumors...
March 22, 2024: Auris, Nasus, Larynx
https://read.qxmd.com/read/38522227/swimming-for-low-back-pain-a-scoping-review
#22
REVIEW
Deborah M Wareham, Joel T Fuller, Tayla J Douglas, Christopher S Han, Mark J Hancock
BACKGROUND: Guidelines recommend exercise for treatment of chronic low back pain and prevention, but the amount and quality of evidence for different exercise modes is highly variable. Swimming is commonly recommended by health professionals, but the extent and quality of research supporting its relationship with back pain is not clear. OBJECTIVES: The aim of this scoping review was to map the extent, characteristics and findings of research investigating the relationship between swimming and low back pain...
March 15, 2024: Musculoskeletal Science & Practice
https://read.qxmd.com/read/38520877/identifying-and-navigating-suspected-serious-pathologies-new-graduate-physiotherapists-perspectives-and-developmental-needs
#23
JOURNAL ARTICLE
Rachel Phua, Allison Mandrusiak, Lakhvir Singh, Romany Martin, Roma Forbes
BACKGROUND: Physiotherapists in Australia play a vital first-contact role in identifying suspected serious pathologies and navigating their management pathways. Current literature highlights challenges faced by physiotherapists including implications of ineffective identification and management of suspected serious pathologies, yet the perspectives of new-graduate physiotherapists related to this area of practice remain unknown. OBJECTIVE: The aim of this study was to explore new-graduate physiotherapists' perspectives and developmental needs related to identifying suspected serious pathologies and navigating their management pathways in patients with musculoskeletal complaints...
March 20, 2024: Musculoskeletal Science & Practice
https://read.qxmd.com/read/38520876/use-of-cupping-therapy-in-musculoskeletal-disorders-a-cross-sectional-study-on-the-profile-training-and-practice-of-brazilian-physical-therapists
#24
JOURNAL ARTICLE
Wesley Rodrigo Costa Rios, Hugo Jario Almeida Silva, Nayara Silva Pontes, André Pontes-Silva, Mariana Arias Avila, Bruno Tirotti Saragiotto, José Jailson de Almeida Júnior, Germanna Medeiros Barbosa, Marcelo Cardoso de Souza
INTRODUCTION: Cupping therapy is a widely used technique in Brazilian physical therapy for the treatment of musculoskeletal disorders. However, there is limited scientific evidence to support its effectiveness. OBJECTIVE: To investigate the profile, training, clinical practice, and scientific updates of Brazilian Physical Therapists who use cupping therapy as a therapeutic resource for musculoskeletal disorders. METHODS: A cross-sectional study was conducted through an online questionnaire, including 646 Physical Therapists who use cupping therapy in their practice...
March 18, 2024: Musculoskeletal Science & Practice
https://read.qxmd.com/read/38520875/towards-a-better-understanding-of-our-patients-a-qualitative-study-about-how-patients-and-their-physiotherapists-perceive-the-recovery-of-shoulder-problems
#25
JOURNAL ARTICLE
Sijmen Hacquebord, Henri Kiers, Philip van der Wees, Thomas J Hoogeboom
OBJECTIVE: To investigate how people with shoulder problems and their physiotherapists perceive the recovery of shoulder problems. METHOD: We performed a qualitative study using semi-structured interviews with patients and their physiotherapists. Nine pairs of patients and physiotherapists (n = 18) were recruited. The transcribed interviews were analyzed in a consecutive multistep iterative process using a conventional content analysis. RESULTS: Analysis of the interviews resulted in three major themes: 'What do I expect from my recovery?', 'Am I recovering?' and 'When do I consider myself recovered?' The patients and physiotherapists talked similarly about the importance of and interdependency between these themes...
March 12, 2024: Musculoskeletal Science & Practice
https://read.qxmd.com/read/38519517/nucleic-acid-base-photofunctional-cocrystal-for-information-security-and-antimicrobial-applications
#26
JOURNAL ARTICLE
Wenqing Xu, Guanheng Huang, Zhan Yang, Ziqi Deng, Chen Zhou, Jian-An Li, Ming-De Li, Tao Hu, Ben Zhong Tang, David Lee Phillips
Cocrystal engineering is an efficient and simple strategy to construct functional materials, especially for the exploitation of novel and multifunctional materials. Herein, we report two kinds of nucleic-acid-base cocrystal systems that imitate the strong hydrogen bond interactions constructed in the form of complementary base pairing. The two cocrystals studied exhibit different colors of phosphorescence from their monomeric counterparts and show the feature of rare high-temperature phosphorescence. Mechanistic studies reveal that the strong hydrogen bond network stabilizes the triplet state and suppresses non-radiative transitions, resulting in phosphorescence even at 425 K...
March 22, 2024: Nature Communications
https://read.qxmd.com/read/38518633/ailanthone-inhibits-non-small-cell-lung-cancer-growth-and-metastasis-through-targeting-upf1-gas5-ulk1-signaling-pathway
#27
JOURNAL ARTICLE
Cheng Fang, Wenbin Wu, Zhongya Ni, Yangli Liu, Jiaojiao Luo, Yufu Zhou, Chenyuan Gong, Dan Hu, Chao Yao, Xiao Chen, Lixin Wang, Shiguo Zhu
BACKGROUND: Targeting long non-coding RNAs (LncRNAs) is a novel and promising approach in cancer therapy. In our previous study, we investigated the effects of ailanthone (aila), the main active compound derived from the stem barks of Ailanthus altissima (Mill.) Swingle, on the growth of non-small cell lung cancer (NSCLC) cells. Although we observed significant inhibition of NSCLC cell growth of aila, the underlying mechanisms involving LncRNAs, specifically LncRNA growth arrest specific 5 (GAS5), remain largely unknown...
December 31, 2023: Phytomedicine
https://read.qxmd.com/read/38518599/utilizing-machine-learning-to-identify-nifuroxazide-as-an-inhibitor-of-ubiquitin-specific-protease-21-in-a-drug-repositioning-strategy
#28
JOURNAL ARTICLE
Jihoon Tak, Tan Khanh Nguyen, Kyeong Lee, Sang Geon Kim, Hee-Chul Ahn
Ubiquitin-specific protease (USP), an enzyme catalyzing protein deubiquitination, is involved in biological processes related to metabolic disorders and cancer proliferation. We focused on constructing predictive models tailored to unveil compounds boasting USP21 inhibitory attributes. Six models, Extra Trees Classifier, Random Forest Classifier, LightGBM Classifier, XGBoost Classifier, Bagging Classifier, and a convolutional neural network harnessed from empirical data were selected for the screening process...
March 21, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38517354/hijacking-and-rewiring-of-host-circrna-mirna-mrna-competitive-endogenous-rna-cerna-regulatory-networks-by-oncoviruses-during-development-of-viral-cancers
#29
REVIEW
Mohammad Javad Kamali, Mohammad Salehi, Mehrnaz Mostafavi, Reza Morovatshoar, Mitra Akbari, Narges Latifi, Omid Barzegari, Fatemeh Ghadimi, Abdolreza Daraei
A significant portion of human cancers are caused by oncoviruses (12%-25%). Oncoviruses employ various strategies to promote their replication and induce tumourigenesis in host cells, one of which involves modifying the gene expression patterns of the host cells, leading to the rewiring of genes and resulting in significant changes in cellular processes and signalling pathways. In recent studies, a specific mode of gene regulation known as circular RNA (circRNA)-mediated competing endogenous RNA (ceRNA) networks has emerged as a key player in this context...
March 2024: Reviews in Medical Virology
https://read.qxmd.com/read/38516893/orai1-inhibition-as-an-efficient-preclinical-therapy-for-tubular-aggregate-myopathy-and-stormorken-syndrome
#30
JOURNAL ARTICLE
Roberto Silva-Rojas, Laura Pérez-Guàrdia, Alix Simon, Sarah Djeddi, Susan Treves, Agnès Ribes, Lorenzo Silva-Hernández, Céline Tard, Jocelyn Laporte, Johann Böhm
Tubular aggregate myopathy (TAM) and Stormorken syndrome (STRMK) are clinically overlapping disorders characterized by childhood-onset muscle weakness and a variable occurrence of multisystemic signs, including short stature, thrombocytopenia, and hyposplenism. TAM/STRMK is caused by gain-of-function mutations in the Ca2+ sensor STIM1 or the Ca2+ channel ORAI1, both of which regulate Ca2+ homeostasis through the ubiquitous store-operated Ca2+ entry (SOCE) mechanism. Functional experiments in cells have demonstrated that the TAM/STRMK mutations induce SOCE overactivation, resulting in excessive influx of extracellular Ca2+...
March 5, 2024: JCI Insight
https://read.qxmd.com/read/38515321/elastic-chain-premaxillary-retraction-appliance-does-not-increase-inter-canthal-dimension-in-patients-with-bilateral-cleft-lip-and-palate
#31
JOURNAL ARTICLE
Hamad Burashed, Cory M Resnick, Elizabeth E Ross, John B Mulliken, Bonnie L Padwa
OBJECTIVE: To determine if the elastic chain premaxillary retraction (ECPR) appliance increases inter-medial and inter-lateral canthal dimension in patients with bilateral complete cleft lip and palate (BCLP). DESIGN: Retrospective cohort study. SETTING: Specialized tertiary care facility. PATIENTS, PARTICIPANTS: 126 patients with BCLP; 75 had ECPR, 51 had no pre-surgical manipulation. INTERVENTIONS: Three-dimensional facial photographs were obtained prior to insertion of appliance (T0), post-appliance therapy prior to appliance removal/labial repair (T1), and several months after labial repair (T2) for a longitudinal ECPR group, and were obtained after age 4 years (T3) for a non-longitudinal ECPR group and for the non-ECPR group...
March 21, 2024: Cleft Palate-craniofacial Journal
https://read.qxmd.com/read/38515190/the-development-of-working-alliance-in-early-stages-of-care-from-the-perspective-of-patients-attending-a-chiropractic-teaching-clinic
#32
JOURNAL ARTICLE
Dima Ivanova, Dave Newell, Jonathan Field, Felicity L Bishop
BACKGROUND: The clinician-patient relationship has consistently been found to predict treatment success in both physical and mental health settings. This relationship has been operationalised in the literature as "Working Alliance," which consists of three key components: patient-clinician agreement on the goals of care, agreement on the tasks required to achieve those goals, and the establishment of a strong bond. While research has demonstrated the impact of working alliance in physical health settings, it often measures working alliance early in patients' care journeys...
March 21, 2024: Chiropractic & Manual Therapies
https://read.qxmd.com/read/38514838/light-mediated-intracellular-polymerization
#33
REVIEW
Mohamed Abdelrahim, Quan Gao, Yichuan Zhang, Weishuo Li, Qi Xing, Mark Bradley, Jin Geng
The synthesis of synthetic intracellular polymers offers groundbreaking possibilities in cellular biology and medical research, allowing for novel experiments in drug delivery, bioimaging and targeted cancer therapies. These macromolecules, composed of biocompatible monomers, are pivotal in manipulating cellular functions and pathways due to their bioavailability, cytocompatibility and distinct chemical properties. This protocol details two innovative methods for intracellular polymerization. The first one uses 2-hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone (Irgacure 2959) as a photoinitiator for free radical polymerization under UV light (365 nm, 5 mW/cm2 )...
March 21, 2024: Nature Protocols
https://read.qxmd.com/read/38514603/photo-switchable-peroxidase-catalase-like-activity-of-carbon-quantum-dots
#34
JOURNAL ARTICLE
Wei Yang, Tianchi Leng, Weicheng Miao, Xiao Cao, Haoran Chen, Feifei Xu, Yimin Fang
Nanozymes possess multi-enzyme activities over the natural enzymes, which produce multi-pathway synergistic effects for varies of biomedical applications. Unfortunately, their multi-enzyme activities are in fighting, significantly reducing the synergistic effects. Dynamic regulation of their multi-enzyme activities is the bottleneck for intelligent therapies. Herein, we construct a novel oxygen-nitrogen functionalized carbon quantum dots (O/N-CQDs) with peroxidase-like (Reactive oxygen species (ROS) producer) activity...
March 21, 2024: Angewandte Chemie
https://read.qxmd.com/read/38514119/-preoperative-simulation-of-neuroendovascular-therapy-using-a-three-dimensional-printer-model-of-a-tailor-made-hollow-cerebral-aneurysm
#35
JOURNAL ARTICLE
Jun Haruma, Ryu Kimura, Masafumi Hiramatsu, Kenji Sugiu
Several studies have reported the importance of preoperative simulations. This report describes the methods and utility of neuroendovascular treatment using a three-dimensional(3D)-printed hollow cerebral aneurysm model. This model was created using a stereolithography apparatus-type 3D printer with digital imaging and communications in medicine data from 3D digital subtraction angiograms. The 3D model was used to perform preoperative simulations of microcatheter placement in aneurysms, microguidewire manipulation, and stent deployment...
March 2024: No Shinkei Geka. Neurological Surgery
https://read.qxmd.com/read/38513728/spatiotemporally-controlled-hydrophobic-drug-delivery-via-photosensitizer-driven-assembly-disassembly-for-enhanced-triple-negative-breast-cancer-treatment
#36
JOURNAL ARTICLE
Fanhui Kong, Peiying He, Jiani Jiang, Wei Zhu, Qi Lei
Therapeutic approaches for triple-negative breast cancer (TNBC) have been continuously advancing, but inadequate control over release behavior, insufficient tumor selectivity, and limited drug availability continue to impede therapeutic outcomes in nanodrug systems. In this study, we propose a general hydrophobic antineoplastic delivery system, termed spatiotemporally-controlled hydrophobic antineoplastic delivery system (SCHADS) for enhanced TNBC treatment. The key feature of SCHADS is the formation of metastable photosensitive-antineoplastic complexes (PACs) through the self-assembly of hydrophobic drugs driven by photosensitive molecules...
March 19, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38513434/local-delivery-of-stem-cell-spheroids-with-protein-polyphenol-self-assembling-armor-to-improve-myocardial-infarction-treatment-via-immunoprotection-and-immunoregulation
#37
JOURNAL ARTICLE
Chuanfeng An, Fei Shao, Canling Long, Yujie Zhang, Wen Nie, Rui Zeng, Zhenzhen Dou, Yuan Zhao, Yuanyuan Lin, Shiying Zhang, Lijun Zhang, Changle Ren, Yang Zhang, Guangqian Zhou, Huanan Wang, Jia Liu
Stem cell therapies have shown great potential for treating myocardial infarction (MI) but are limited by low cell survival and compromised functionality due to the harsh microenvironment at the disease site. Here, we presented a Mesenchymal stem cell (MSC) spheroid-based strategy for MI treatment by introducing a protein/polyphenol self-assembling armor coating on the surface of cell spheroids, which showed significantly enhanced therapeutic efficacy by actively manipulating the hostile pathological MI microenvironment and enabling versatile functionality, including protecting the donor cells from host immune clearance, remodeling the ROS microenvironment and stimulating MSC's pro-healing paracrine secretion...
March 8, 2024: Biomaterials
https://read.qxmd.com/read/38513337/health-coaching-intervention-with-or-without-the-support-of-an-exercise-buddy-to-increase-physical-activity-of-people-with-chronic-low-back-pain-compared-to-usual-care-a-feasibility-and-pilot-randomised-controlled-trial
#38
JOURNAL ARTICLE
Carolina G Fritsch, Manuela L Ferreira, Mark H Halliday, Katharine Roberts, Josielli Comachio, Manasi Mittinty, Louise Sharpe, Nadine E Foster, Emmanuel Stamatakis, Paul J Mork, Andrew J McLachlan, Paulo H Ferreira
BACKGROUND: Exercise buddies (people to exercise together with) might support people with low back pain (LBP) to become active. However, involving buddies in randomised controlled trials (RCT) might challenge recruitment, data collection and follow-up. OBJECTIVES: To explore the feasibility of the intervention, recruitment and data collection approaches and potential effects of a health coaching intervention (focused on physical activity) with or without exercise buddies' support on physical activity of people with chronic LBP versus usual discharge care...
March 16, 2024: Musculoskeletal Science & Practice
https://read.qxmd.com/read/38511486/chronic-pain-and-the-use-of-complementary-and-alternative-medicine-in-rural-victoria-australia
#39
JOURNAL ARTICLE
Andrew J Hamilton, Lisa Bourke, Geetha Ranmuthugala, Kristen M Glenister, David Simmons
OBJECTIVE: The relationship between chronic pain and complementary and alternative medicine (CAM) use is poorly understood, and the situation in rural Australia is particularly unclear. The objective here was to determine the socio-demographic factors associated with the use of CAM for the treatment of chronic pain in a region of rural Australia. METHODS: This secondary analysis used data from a population health survey, Crossroads-II, to assess the relationships of various socio-demographic factors with the use of CAM by those suffering from chronic pain...
March 21, 2024: Australian Journal of Rural Health
https://read.qxmd.com/read/38509882/the-therapeutic-landscape-for-covid-19-and-post-covid-19-medications-from-genetic-profiling-of-the-vietnamese-population-and-a-predictive-model-of-drug-drug-interaction-for-comorbid-covid-19-patients
#40
JOURNAL ARTICLE
Thien Khac Nguyen, Giang Minh Vu, Vinh Chi Duong, Thang Luong Pham, Nguyen Thanh Nguyen, Trang Thi Ha Tran, Mai Hoang Tran, Duong Thuy Nguyen, Nam S Vo, Huong Thanh Phung, Tham Hong Hoang
Despite the raised awareness of the role of pharmacogenomic (PGx) in personalized medicines for COVID-19, data for COVID-19 drugs is extremely scarce and not even a publication on this topic for post-COVID-19 medications to date. In the current study, we investigated the genetic variations associated with COVID-19 and post-COVID-19 therapies by using whole genome sequencing data of the 1000 Vietnamese Genomes Project (1KVG) in comparison with other populations retrieved from the 1000 Genomes Project Phase 3 (1KGP3) and the Genome Aggregation Database (gnomAD)...
March 30, 2024: Heliyon
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