Chuanfeng An, Fei Shao, Canling Long, Yujie Zhang, Wen Nie, Rui Zeng, Zhenzhen Dou, Yuan Zhao, Yuanyuan Lin, Shiying Zhang, Lijun Zhang, Changle Ren, Yang Zhang, Guangqian Zhou, Huanan Wang, Jia Liu
Stem cell therapies have shown great potential for treating myocardial infarction (MI) but are limited by low cell survival and compromised functionality due to the harsh microenvironment at the disease site. Here, we presented a Mesenchymal stem cell (MSC) spheroid-based strategy for MI treatment by introducing a protein/polyphenol self-assembling armor coating on the surface of cell spheroids, which showed significantly enhanced therapeutic efficacy by actively manipulating the hostile pathological MI microenvironment and enabling versatile functionality, including protecting the donor cells from host immune clearance, remodeling the ROS microenvironment and stimulating MSC's pro-healing paracrine secretion...
March 8, 2024: Biomaterials