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Manipulation therapy

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https://www.readbyqxmd.com/read/29456568/harnessing-the-immune-system-in-the-battle-against-breast-cancer
#1
REVIEW
Elizabeth S Nakasone, Sara A Hurvitz, Kelly E McCann
Breast cancer is the most prevalent malignancy in women and the second most common cause of cancer-related death worldwide. Despite major innovations in early detection and advanced therapeutics, up to 30% of women with node-negative breast cancer and 70% of women with node-positive breast cancer will develop recurrence. The recognition that breast tumors are infiltrated by a complex array of immune cells that influence their development, progression, and metastasis, as well as their responsiveness to systemic therapies has sparked major interest in the development of immunotherapies...
2018: Drugs in Context
https://www.readbyqxmd.com/read/29456442/the-effect-of-direction-specific-thoracic-spine-manipulation-on-the-cervical-spine-a-randomized-controlled-trial
#2
Steve Karas, Megan J Olson Hunt, Bill Temes, Martin Thiel, Trenton Swoverland, Brett Windsor
Objectives: To determine the difference on neck outcomes with directional manipulation to the thoracic spine. There is evidence that thoracic spine manipulation is effective in treating patients with neck pain. However, there is no research that determines if the assessment of directional hypomobility and the selection of thrust direction offer improved outcomes. Methods: A total of 69 patients with cervical spine pain were randomly assigned to receive either a manipulation that was consistent with their thoracic spine motion loss (matched) or opposite their motion loss (unmatched)...
February 2018: Journal of Manual & Manipulative Therapy
https://www.readbyqxmd.com/read/29456441/we-need-to-debate-the-value-of-manipulative-therapy-and-recognize-that-we-do-not-always-understand-from-what-to-attribute-our-success
#3
EDITORIAL
Steve Karas, Paul Mintken, Jean-Michel Brismée
No abstract text is available yet for this article.
February 2018: Journal of Manual & Manipulative Therapy
https://www.readbyqxmd.com/read/29454929/hur-mediated-scn5a-mrna-stability-reduces-arrhythmic-risk-in-heart-failure
#4
Anyu Zhou, An Xie, Tae Yun Kim, Hong Liu, Guangbin Shi, Gyeoung-Jin Kang, Ning Jiang, Man Liu, Euy-Myoung Jeong, Bum-Rak Choi, Samuel C Dudley
BACKGROUND: Downregulated sodium currents in heart failure (HF) has been linked to increased arrhythmic risk. Reduced expression of mRNA stabilizing protein ELAVL1/HuR may be responsible for the downregulation of sodium channel gene SCN5A mRNA. OBJECTIVE: To investigate whether HuR regulates SCN5A mRNA expression and whether manipulation of HuR benefits arrhythmia control in HF. METHODS: Quantitative real-time reverse-transcriptase PCR (qRT-PCR) were used to investigate the expression of SCN5A...
February 15, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29453446/environmental-genetic-and-epigenetic-contributions-to-cocaine-addiction
#5
REVIEW
R Christopher Pierce, Bruno Fant, Sarah E Swinford-Jackson, Elizabeth A Heller, Wade H Berrettini, Mathieu E Wimmer
Decades of research on cocaine has produced volumes of data that have answered many important questions about the nature of this highly addictive drug. Sadly, none of this information has translated into the development of effective therapies for the treatment of cocaine addiction. This review endeavors to assess the current state of cocaine research in an attempt to identify novel pathways for therapeutic development. For example, risk of cocaine addiction is highly heritable but genome-wide analyses comparing cocaine-dependent individuals to controls have not resulted in promising targets for drug development...
February 5, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29451199/brain-injury-and-neural-stem-cells
#6
REVIEW
Parker E Ludwig, Finosh G Thankam, Arun A Patil, Andrea J Chamczuk, Devendra K Agrawal
Many therapies with potential for treatment of brain injury have been investigated. Few types of cells have spurred as much interest and excitement as stem cells over the past few decades. The multipotentiality and self-renewing characteristics of stem cells confer upon them the capability to regenerate lost tissue in ischemic or degenerative conditions as well as trauma. While stem cells have not yet proven to be clinically effective in many such conditions as was once hoped, they have demonstrated some effects that could be manipulated for clinical benefit...
January 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29449770/adverse-events-following-cervical-manipulative-therapy-consensus-on-classification-among-dutch-medical-specialists-manual-therapists-and-patients
#7
Hendrikus A Kranenburg, Sandra E Lakke, Maarten A Schmitt, Cees P Van der Schans
Objectives: To obtain consensus-based agreement on a classification system of adverse events (AE) following cervical spinal manipulation. The classification system should be comprised of clear definitions, include patients' and clinicians' perspectives, and have an acceptable number of categories. Methods: Design : A three-round Delphi study. Participants : Thirty Dutch participants (medical specialists, manual therapists, and patients) participated in an online survey...
December 2017: Journal of Manual & Manipulative Therapy
https://www.readbyqxmd.com/read/29449769/translational-manipulation-under-anesthesia-for-patients-with-frozen-shoulder-a-case-series-study-with-five-year-health-care-utilization-and-post-manipulative-arthroscopic-findings
#8
Ben R Hando, Daniel I Rhon, Robert E Boyles, Julie M Whitman, Jenny L English
Study Design: Case series study. Objectives: Although there have been no reported complications from translational manipulation under anesthesia (tMUA) for individuals with adhesive capsulitis (AC) there are no cases reporting surgical findings post tMUA. Also, there are no studies evaluating health care utilization following tMUA. The purpose of this study was to: (1) report clinical outcomes following tMUA, (2) describe relevant health care costs and utilization following tMUA, and (3) summarize findings from two cases receiving joint arthroscopy following tMUA...
December 2017: Journal of Manual & Manipulative Therapy
https://www.readbyqxmd.com/read/29448252/functions-and-roles-of-long-non-coding-rnas-in-human-nasopharyngeal-carcinoma
#9
JingJing Wu, Swei Sunny Hann
Nasopharyngeal carcinoma (NPC) is one of the most common cancers originating in the nasopharynx and occurring at high frequency in South-eastern Asia and North Africa. Long non-coding RNAs (lncRNAs) are a class of non-protein-coding RNA molecules and key regulators of developmental, physiological, and pathological processes in humans. Emerging studies have shown that lncRNAs play critical roles in tumorgenicity and cancer prognosis. With the development of deep sequencing analyses, an extensive amount of functional lncRNAs have been discovered in nasopharyngeal carcinoma tissues and cell lines...
February 9, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29448116/immunoliposomes-in-clinical-oncology-state-of-the-art-and-future-perspectives
#10
REVIEW
María Merino, Sara Zalba, María J Garrido
Liposomal formulations entrapping a vast number of molecules have improved cancer therapies overcoming certain pharmacokinetic (PK) and pharmacodynamic limitations, many of which are associated with tumor characteristics. In this context, immunoliposomes represent a new strategy that has been widely investigated in preclinical cancer models with promising results, although few have reached the stage of clinical trials. This contrasts with the emerging clinical application of monoclonal antibodies (mAbs). This formulation allows the conjugation of different mAbs or antibody derivatives, such as monovalent variable fragments Fab', to the polymers covering the surface of liposomes...
February 12, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29447015/optogenetics-in-cancer-drug-discovery
#11
Michał Kiełbus, Jakub Czapiński, Adrian Odrzywolski, Grażyna Stasiak, Kamila Szymańska, Joanna Kałafut, Michał Kos, Krzysztof Giannopoulos, Andrzej Stepulak, Adolfo Rivero-Müller
The discovery and domestication of biomolecules that respond to light has taken a light of its own, providing new molecular tools with incredible spatio-temporal resolution to manipulate cellular behavior. Areas covered: The authors herein analyze the current optogenetic tools in light of their current, and potential, uses in cancer drug discovery, biosafety and cancer biology. Expert opinion: The pipeline from drug discovery to the clinic is plagued with drawbacks, where most drugs fail in either efficacy or safety...
February 15, 2018: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/29446873/laser-stimulating-st36-with-optical-fiber-induce-blood-component-changes-in-mice-a-raman-spectroscopy-study
#12
Heng Zhang, Zhenyi Chen, Jiping Wu, Na Chen, Wenjie Xu, Taihao Li, Shupeng Liu
ST36 is a commonly-used acupoint in traditional Chinese medicine (TCM) for treatment of inflammations, pains and gastrointestinal disturbs. For decades,the low power laser acupuncture has been widely applied as an alternative therapy to traditional metal needle acupuncture and achieved relatively fine therapeutic effect for ST36-related symptoms with reduction of uncomfortableness and infection risks. However its disadvantages of low penetrativity and lack of manipulation skills limit its potential performance...
February 15, 2018: Journal of Biophotonics
https://www.readbyqxmd.com/read/29445226/gcy-35-gcy-36-tax-2-tax-4-signalling-in-o-2-sensory-neurons-mediates-acute-functional-ethanol-tolerance-in-caenorhabditis-elegans
#13
Yuan-Hua Chen, Chang-Li Ge, Hong Wang, Ming-Hai Ge, Qing-Qin He, Yu Zhang, Wei Tian, Zheng-Xing Wu
Ethanol is a widely used beverage and abused drug. Alcoholism causes severe damage to human health and creates serious social problems. Understanding the mechanisms underlying ethanol actions is important for the development of effective therapies. Alcohol has a wide spectrum of effects on physiological activities and behaviours, from sensitization to sedation and even intoxication with increasing concentrations. Animals develop tolerance to ethanol. However, the underlying mechanisms are not well understood...
February 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29443786/improved-vacuum-sealing-drainage-for-treatment-of-surgical-site-infection-following-posterior-spinal-internal-fixation-a-case-report
#14
Hengyan Zhang, Qiyi Li
RATIONALE: Surgical site infection (SSI) following spine surgeries involving internal fixation often require removing the instrument; however, this can cause spinal instability. Previous reports have demonstrated the usefulness of vacuum sealing drainage (VSD) therapy, but the cases require wound opening, aseptic condition to replace the VSD device, and a secondary operation to close the wound. Thus, to improve the VSD treatment and develop a maneuverable procedure, make sense in spine surgery...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29443657/il-2-and-beyond-in-cancer-immunotherapy
#15
John M Wrangle, Alicia Patterson, C Bryce Johnson, Daniel J Neitzke, Shikhar Mehrotra, Chadrick E Denlinger, Chrystal M Paulos, Zihai Li, David J Cole, Mark P Rubinstein
The development of the T- and natural killer (NK) cell growth factor IL-2 has been a sentinel force ushering in the era of immunotherapy in cancer. With the advent of clinical grade recombinant IL-2 in the mid-1980s, oncologists could for the first time directly manipulate lymphocyte populations with systemic therapy. By itself, recombinant IL-2 can induce clinical responses in up to 15% of patients with metastatic cancer or renal cell carcinoma. When administered with adoptively transferred tumor-reactive lymphocytes, IL-2 promotes T cell engraftment and response rates of up to 50% in metastatic melanoma patients...
February 2018: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/29443430/small-scale-machines-driven-by-external-power-sources
#16
REVIEW
Xiang-Zhong Chen, Bumjin Jang, Daniel Ahmed, Chengzhi Hu, Carmela De Marco, Marcus Hoop, Fajer Mushtaq, Bradley J Nelson, Salvador Pané
Micro- and nanorobots have shown great potential for applications in various fields, including minimally invasive surgery, targeted therapy, cell manipulation, environmental monitoring, and water remediation. Recent progress in the design, fabrication, and operation of these miniaturized devices has greatly enhanced their versatility. In this report, the most recent progress on the manipulation of small-scale robots based on power sources, such as magnetic fields, light, acoustic waves, electric fields, thermal energy, or combinations of these, is surveyed...
February 14, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29443073/percutaneous-contrast-echocardiography-guided-intramyocardial-injection-and-cell-delivery-in-a-large-preclinical-model
#17
Alejandro Giraldo, Jesús Talavera López, Maria Josefa Fernandez-Del-Palacio, Obdulio García-Nicolás, Juan Seva, Gavin Brooks, José María Moraleda
Cell and gene therapy are exciting and promising strategies for the purpose of cardiac regeneration in the setting of heart failure with reduced ejection fraction (HFrEF). Before they can be considered for use, and implemented in humans, extensive preclinical studies are required in large animal models to evaluate the safety, efficacy, and fate of the injectate (e.g., stem cells) once delivered into the myocardium. Small rodent models offer advantages (e.g., cost effectiveness, amenability for genetic manipulation); however, given inherent limitations of these models, the findings in these rarely translate into the clinic...
January 21, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29440069/therapeutic-opportunities-in-eukaryotic-translation
#18
Jennifer Chu, Jerry Pelletier
The ability to block biological processes with selective small molecules provides advantages distinct from most other experimental approaches. These include rapid time to onset, swift reversibility, ability to probe activities in manners that cannot be accessed by genetic means, and the potential to be further developed as therapeutic agents. Small molecule inhibitors can also be used to alter expression and activity without affecting the stoichiometry of interacting partners. These tenets have been especially evident in the field of translation...
February 12, 2018: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/29439744/an-investigation-into-closed-loop-treatment-of-neurological-disorders-based-on-sensing-mitochondrial-dysfunction
#19
REVIEW
Scott D Adams, Abbas Z Kouzani, Susannah J Tye, Kevin E Bennet, Michael Berk
Dynamic feedback based closed-loop medical devices offer a number of advantages for treatment of heterogeneous neurological conditions. Closed-loop devices integrate a level of neurobiological feedback, which allows for real-time adjustments to be made with the overarching aim of improving treatment efficacy and minimizing risks for adverse events. One target which has not been extensively explored as a potential feedback component in closed-loop therapies is mitochondrial function. Several neurodegenerative and psychiatric disorders including Parkinson's disease, Major Depressive disorder and Bipolar disorder have been linked to perturbations in the mitochondrial respiratory chain...
February 13, 2018: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/29439241/near-infrared-deep-brain-stimulation-via-upconversion-nanoparticle-mediated-optogenetics
#20
Shuo Chen, Adam Z Weitemier, Xiao Zeng, Linmeng He, Xiyu Wang, Yanqiu Tao, Arthur J Y Huang, Yuki Hashimotodani, Masanobu Kano, Hirohide Iwasaki, Laxmi Kumar Parajuli, Shigeo Okabe, Daniel B Loong Teh, Angelo H All, Iku Tsutsui-Kimura, Kenji F Tanaka, Xiaogang Liu, Thomas J McHugh
Optogenetics has revolutionized the experimental interrogation of neural circuits and holds promise for the treatment of neurological disorders. It is limited, however, because visible light cannot penetrate deep inside brain tissue. Upconversion nanoparticles (UCNPs) absorb tissue-penetrating near-infrared (NIR) light and emit wavelength-specific visible light. Here, we demonstrate that molecularly tailored UCNPs can serve as optogenetic actuators of transcranial NIR light to stimulate deep brain neurons. Transcranial NIR UCNP-mediated optogenetics evoked dopamine release from genetically tagged neurons in the ventral tegmental area, induced brain oscillations through activation of inhibitory neurons in the medial septum, silenced seizure by inhibition of hippocampal excitatory cells, and triggered memory recall...
February 9, 2018: Science
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