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Liv Østevik, Kathrine Rudlang, Tuva Holt Jahr, Mette Valheim, Bradley Lyndon Njaa
BACKGROUND: An aural cholesteatoma, more appropriately named tympanokeratoma, is an epidermoid cyst of the middle ear described in several species, including dogs, humans and Mongolian gerbils. The cyst lining consists of stratified, keratinizing squamous epithelium with central accumulation of a keratin debris. This case report describes vestibular ganglioneuritis and perineuritis in a dog with chronic otitis, bilateral tympanokeratomas and presumed extension of otic infection to the central nervous system...
May 22, 2018: Acta Veterinaria Scandinavica
Pritesh Jain, Dilip Kumar Pal
Pelvic retroperitoneum is a bizarre location of an epidermoid cyst and obstructive voiding caused by it even being stranger. Voiding symptoms related to such an abnormal location of cyst are extremely rare and literature that taps into such cases is scarce. We are presenting here a case of 26-year-old man who was presented with obstructive lower urinary tract symptoms and chronic constipation. On evaluation, he was found to have well-defined cyst in pelvic retroperitoneum. Complete excision of the cyst was done; histopathology confirmed it as an epidermoid cyst...
May 18, 2018: BMJ Case Reports
Krishnamurthy Sridhar, Mukul Vij
Intracranial epidermoids are generally seen as hypodense nonenhancing lesions on computed tomography scans; and, as T1 hypointense and T2 hyperintense lesions on magnetic resonance imaging (MRI). Unusual radiological findings have been reported earlier. The authors present the case of a 54-year old male patient who had prior intracranial surgery. On MRI, there was a thick peripheral mantle of diffusion restriction with a central core of brilliant T1 hyperintensity and very black T2 hypointensity. The peripheral mantle showing diffusion restriction was heterogeneously T1 hypointense and T2 hyperintense...
May 2018: Neurology India
V E Prez, L C Martínez, M Victoria, M O Giordano, G Masachessi, V E Ré, J V Pavan, R Colina, P A Barril, S V Nates
Consumption of green vegetable products is commonly viewed as a potential risk factor for infection with enteric viruses. The link between vegetable crops and fecally contaminated irrigation water establishes an environmental scenario that can result in a risk to human health. The aim of this work was to analyze the enteric viral quality in leafy green vegetables from Córdoba (Argentina) and its potential association with viral contamination of irrigation waters. During July-December 2012, vegetables were collected from peri-urban green farms (n = 19) and its corresponding urban river irrigation waters (n = 12)...
May 11, 2018: Science of the Total Environment
Douglas Jordan-Ribeiro, Laura Machado Lara Carvalho, Raquel Vilela, Dayse Danielle Rocha, Paula Lopes Ruas, Antônio Ferreira Ávila, Denis Vasconcelos Ferreira, Eduardo Mateus Motta Trindade, Paulo Henrique Pimentel Santos, Monica Assunção Costa Lima, Leonel Mendoza, Rudolf Huebner
PURPOSE: Severe physical facial deformities due to surgical interventions can have significant psychosocial consequences to patient's relationships with friends and family and thus, has a considerable impact on their quality of life. We have developed a 3D prosthesis for a 56-year-old woman diagnosed with epidermoid carcinoma at the right hemiface, to improve her quality of life. METHODS: The patient started radiotherapy with modulated intensity. To deal with the advance of the process, a maxilectomy of supra structure with modified radical cervical emptying on the right hemiface was performed...
May 3, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Qian Li, Yu-Sheng Peng, Ping-Jiao Chen, Meng-Lei Wang, Can Cao, Hao Xiong, Jing Zhang, Ming-Hua Chen, Xue-Biao Peng, Kang Zeng
Evidence suggests that peroxisome proliferator activated receptor-γ (PPAR-γ) acts as a tumor suppressor in multiple types of cancer; however, the role of action of PPAR-γ on human epidermoid carcinoma is unclear. The present study investigated the effects of a PPAR-γ agonist, rosiglitazone, on human epidermoid carcinoma cell growth using the A431 cell line. The effects of rosiglitazone on cell viability and proliferation were evaluated with MTS and [3 H] thymidine incorporation assays. The effects of rosiglitazone on the cell cycle and apoptosis were analyzed by flow cytometry, and western blotting...
May 2018: Oncology Letters
Aina Brunet-Garcia, Elizabeth-Daniela Lucena-Rivero, Laia Brunet-Garcia, Marta Faubel-Serra
Background: Epidermoid and dermoid cysts in the oral cavity are relatively uncommon lesions of developmental origin. They often remain asymptomatic for years until they grow enough to interfere with speech, deglutition and less often with breathing which can pose a critical risk to the airway and require immediate surgery. Case description: A case of an epidermoid cyst of the floor of the mouth affecting a 37-year-old man is presented; this lesion was surgically enucleated with an intraoral approach...
March 2018: Journal of Clinical and Experimental Dentistry
P Liu, W Li, H C Song, L L Jiao, W P Zhang, N Sun
INTRODUCTION: Prepubertal testicular tumors are fundamentally distinct from their postpubertal and adult counterparts. Racial and ethnic differences contribute to the incidence, characteristics, and histological distribution of prepubertal testicular germ cell tumors (PTGCTs). OBJECTIVE: To elucidate the characteristics and treatment outcomes of PTGCTs in a Chinese cohort. STUDY DESIGN: Data were retrospectively reviewed from consecutive PTGCT patients aged <12 years who received treatment at the current institution from January 2007 to December 2015...
April 3, 2018: Journal of Pediatric Urology
Abdurrahim Kocyigit, Eray Metin Guler, Ersin Karatas, Hifa Caglar, Huri Bulut
New in vitro studies have demonstrated that N-acetyl-5-methoxytryptamine (Melatonin) has cytotoxic and apoptotic effects on various cell types although most of the previous investigations document that it is a potent antioxidant. However, the precise molecular mechanism(s) of its effects are not fully elucidated. In this study, we examined dose-dependent cytotoxic, genotoxic, apoptotic and reactive oxygen species (ROS) generating effects of melatonin in human epidermoid carcinoma cells (A-431) and human normal skin fibroblastic cells (CCD-1079Sk)...
May 2018: Mutation Research
Maria Vittoria Cicinelli, Swathi Kaliki
PURPOSE: To review and summarize the newest update on ocular sebaceous gland carcinoma (SGC) focusing on diagnosis and treatment. METHODS: A PubMed search was carried out using the terms "Sebaceous Carcinoma", "Meibomian Gland Carcinoma", "Sebaceous Cell Carcinoma", and "Sebaceous Gland Carcinoma". All studies published in English up to October 2017 were included in this review. RESULTS: Globally, the overall incidence of SGC is increasing making it the third most common eyelid malignancy after basal cell carcinoma (BCC) and squamous cell carcinoma...
April 25, 2018: International Ophthalmology
Jonathan E Mayer, Misha D Miller, Stanca A Birlea
No abstract text is available yet for this article.
May 2018: JAAD Case Reports
Arun Oommen, Jayasree Govindan, Devan Surendran Peroor, C Roshan Azeez, R Rashmi, Muhammed Jasim Abdul Jalal
Intraparenchymal or intradiploic epidermoid cysts are very rare. Most of these cysts, when present, tend to involve the frontal and temporal lobes, and occasionally, the pineal gland or the brain stem. Here, we report a 45-year-old female, who presented with localized occipital headache and a tender occipital swelling, gradually increasing in size. She was hemodynamically and neurologically stable and did not have any focal neurological deficits. Whole skull and brain imaging revealed a well-demarcated expansile lytic lesion in the right occipital bone, which was hypointense on T1-weighted and hyperintense on both T2-weighted imaging and diffusion-weighted imaging without any contrast enhancement...
April 2018: Asian Journal of Neurosurgery
Bellakhdhar Mouna, El Abed Wed, Mestiri Sarra, Majdoub Senda, Kermani Wassim, Abdelkefi Mohamed
INTRODUCTION: Malignant degeneration of a branchial cyst is rare [1]. It varies from 4% to 22% [2]. CASE: Report: A74-year-old man presented to our department with a left painless upper neck mass which was excised and histopathology revealed squamous cell carcinoma in a cystic lesion. The appropriate clinical tests and imaging were performed to determine the possible presence of a primary tumor. No primary carcinoma was found. This finding suggests that this was a malignant degeneration of a branchial cyst...
April 18, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
B Ramesh Kumar, Apoorva Anupam, Padmavati Manchikanti, Arun Prabhu Rameshbabu, Swagata Dasgupta, Santanu Dhara
Basella is an important green leafy vegetable species of Chenopodiaceae family and is known for its medicinal properties. Hydroxy-benzoic acids, hydroxy-cinnamic acids and flavones groups were identified and characterized from the aqueous stem extracts of B. alba and B. rubra species. Higher values of phenolics as well as antioxidant activity were noted from B. alba species extracts. The evaluation of the cytoxicity of these extracts on A431 (epidermoid carcinoma), Hep G2 (hepatocellular carcinoma) and MG 63 (osteosarcoma) cells indicated anti-proliferative activity against all the cell lines...
May 2018: Journal of Food Science and Technology
Renwei Liu, Zhengxian Lei, Nengxue Chen, Jinzhi Fang, Yuzhong Zhang
OBJECTIVE: To evaluate the utility of findings on ultrasound and magnetic resonance imaging (MRI) for the preoperative diagnosis of testicular epidermoid cysts (TEC). METHODS: The medical records of five patients treated for TEC at our institution between July 2010 and May 2017 were retrospectively reviewed. RESULTS: Imaging revealed a target or onion skin appearance on ultrasonography and MRI. Pathological examinations showed "bread slag-like" materials within the TEC...
April 5, 2018: Clinical Imaging
Lianjun Di, Kuang-I Fu, Xuemei Liu, Rong Zhu, Bigung Tuo
No abstract text is available yet for this article.
April 5, 2018: Gastrointestinal Endoscopy
Anghela Paredes, Eliza Wright Beal, Mary E Dillhoff
This is a case of an epidermoid cyst in an intrapancreatic accessory spleen at the tail of the pancreas. Concurrent epidermoid cyst within the accessory spleen is an exceedingly rare entity. The patient initially presented with abdominal pain, nausea and vomiting. Imaging studies revealed a 3.6 cm cystic mass in the tail of the pancreas that was concerning for a mucinous cystic neoplasm (MCN). The patient underwent a robotic distal pancreatectomy for a suspected diagnosis of MCN, which following histologically examination was found to be an epidermoid cyst of an intrapancreatic accessory spleen...
April 5, 2018: BMJ Case Reports
Thomas Sorenson, Giuseppe Lanzino
Intramedullary epidermoid cysts are extremely rare lesions. Preoperative diagnosis can be challenging due to non-specific imaging futures. We illustrate the case of a 32-year-old man who presented with a symptomatic intramedullary mass, which at surgery proved to be an epidermoid cyst. The spinal cord was decompressed by removing the pearl-white keratin material, although the capsule, which was tenaciously adherent to the surrounding spinal cord parenchyma, was only partially removed. In this video, we illustrate the salient surgical points for the resection of this very unusual intramedullary lesion...
March 30, 2018: Operative Neurosurgery (Hagerstown, Md.)
Jingwen Tan, Jia Chen, Lianjuan Yang
Schwannoma is a generally benign tumor of the peripheral nerve sheath arising from Schwann cells. Most schwannomas are found on the head and neck. Here, we describe a rare case of benign vulvar schwannoma located at the labium majus which was similar to an epidermoid cyst in clinical appearance.
January 2018: Case Reports in Dermatology
Sadiya Khwaja, Kaneez Fatima, Hassanain, Chittaranjan Behera, Avneet Kour, Arjun Singh, Suaib Luqman, Jayanta Sarkar, Debabrata Chanda, Karuna Shanker, A K Gupta, D M Mondhe, Arvind S Negi
Curcumin possesses an attractive chemical structure with highly conjugated diferuloylmethane core. Curcumin mimics have been designed and prepared with an additional bridged phenyl ring in conjugation. Fourteen diverse analogues were evaluated against a panel of human cancer cell lines. The best analogue of the series i.e. compound 6a exhibited potent cytotoxicity against A431, epidermoid carcinoma cell line (IC50  = 1.5 μM) and DLD1, colorectal adenocarcinoma cell line (IC50  = 6.9 μM). In tubulin kinetics experiment, compound 6a destabilized polymerisation process (IC50  = 4...
March 26, 2018: European Journal of Medicinal Chemistry
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