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https://www.readbyqxmd.com/read/29348457/ltbp3-promotes-early-metastatic-events-during-cancer-cell-dissemination
#1
Elena I Deryugina, Ewa Zajac, Lior Zilberberg, Tomoki Muramatsu, Grishma Joshi, Branka Dabovic, Daniel Rifkin, James P Quigley
Latent transforming growth factor β (TGFβ)-binding proteins (LTBPs) are important for the secretion, activation, and function of mature TGFβ, especially so in cancer cell physiology. However, specific roles of the LTBPs remain understudied in the context of the primary tumor microenvironment. Herein, we investigated the role of LTBP3 in the distinct processes involved in cancer metastasis. By using three human tumor cell lines of different tissue origin (epidermoid HEp-3 and prostate PC-3 carcinomas and HT-1080 fibrosarcoma) and several metastasis models conducted in both mammalian and avian settings, we show that LTBP3 is involved in the early dissemination of primary cancer cells, namely in the intravasation step of the metastatic cascade...
January 19, 2018: Oncogene
https://www.readbyqxmd.com/read/29325939/liponeurocytoma-of-the-cerebello-pontine-angle
#2
Carmela Chiaramonte, Sylvain Rabaste, Timothee Jacquesson, David Meyronet, François Cotton, Emmanuel Jouanneau, Moncef Berhouma
Liponeurocytoma is a very rare tumor classified as grade II (neuronal and mixed neuronal-glial tumors) according to 2016 WHO classification of Tumors of the Central Nervous System. The median age is 50-years-old and the most frequent location is the posterior cranial fossa especially within the cerebellar hemispheres; those arising in the cerebellopontine angle are exceptional. We herein report the clinical, radiological and pathological characteristics of a cerebellopontine angle liponeurocytoma in a 35-year-old woman...
January 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29323077/epidermoid-cyst-of-the-renal-pelvis-masquerading-as-malignancy
#3
Dinesh Pradhan, Gabriela Quiroga-Garza, Ronald Hrebinko, Rajiv Dhir, Anil V Parwani
Epidermoid cyst of the renal pelvis is exceptionally rare. The histogenetic mechanism has not been well characterized. Herein, we report a case of intrarenal epidermoid cyst in a 62-year-old woman who had undergone left nephrolithotomy for a staghorn calculus. She was being followed up for bilateral renal cysts when a complex mass was noted arising from the lower pole of the left kidney. Renal ultrasound showed a small left kidney with a solid vascular echogenic mass. A laparoscopic radical nephrectomy was performed...
October 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29306149/a-case-report-of-intrarenal-epidermoid-cysts-in-a-yellow-bellied-slider-trachemys-scripta-scripta
#4
Simon Stokes, Nicola Di Girolamo, Paolo Selleri, Sara Pagliarani, Chiara Palmieri
A 7-year-old yellow-bellied slider exhibited anorexia, decreased activity, generalised wasting of skeletal muscles and oedema. Haematology examination revealed increased phosphorus and decreased calcium levels. During necropsy performed after spontaneous death, a focal nodular lesion containing tan amorphous material was found in the left kidney. Histopathology examination revealed multiple cystic lesions lined by a multilayered squamous, occasionally cuboidal, and containing keratin. Epithelial cells and keratin material were cytokeratin-positive...
December 27, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/29300964/piezosurgery-a-safe-technique-to-perform-lateral-suboccipital-craniotomy
#5
Juergen Grauvogel, Waseem Masalha, Dieter Henrik Heiland, Nadja Jarc, Tanja Daniela Grauvogel, Christian Scheiwe
BACKGROUND: Piezosurgery (PS) is a relatively new technique based on microvibrations generated by the piezoelectric effect. It selectively cuts bone tissue and preserves the surrounding soft tissue. OBJECTIVE: To evaluate the use of PS for performing lateral suboccipital craniotomy. METHODS: PS was used to perform a lateral suboccipital craniotomy in 22 patients who underwent surgery for different cerebellopontine angle (CPA) pathologies in the neurosurgical department...
December 29, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29286920/resveratrol-enhances-the-effects-of-ala-pdt-on-skin-squamous-cells-a431-through-p38-mapk-signaling-pathway
#6
Xin Zhang, Xia Liu, Shuxia Kang, Caiyun Liu, Yuqin Hao
AIMS AND BACKGROUND: Squamous cell carcinoma (SCC) is one of the most common skin cancers. Photodynamic therapy (PDT) is a non-invasive treatment for SCC, but it is usually effective only on tumors just under the skin. Resveratrol (Res) is a polyphenolic compound, which is capable of promoting apoptosis of a variety of cancer cells. Res administration is non-invasive and effective on SCC, thus it may be used as an adjuvant for PDT. So far, there is no published study investigating the combination use of PDT with Res to improve clinical outcome of SCC...
December 23, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29274165/epidemiologic-study-of-odontogenic-and-non-odontogenic-cysts-in-children-and-adolescents-of-a-brazilian-population
#7
L-P da Silva, A Gonzaga, M Severo, C-S Barros, A de Medeiros, L de Souza, É da Silveira
BACKGROUND: the objective of this study was to describe the frequency of cystic lesions in a Brazilian population of patients histopathologically diagnosed in the first and second decade of life. MATERIAL AND METHODS: Retrospective descriptive cross-sectional study was performed. Biopsy records were obtained from the archives of a Brazilian referral center between 1980 and 2016. RESULTS: A total of 2.114 biopsy records of pediatric patients were analyzed with oral and maxillofacial lesions...
December 23, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29274149/evolution-of-oral-neoplasm-in-an-andalusian-population-spain
#8
R Flores-Ruiz, L Castellanos-Cosano, M-A Serrera-Figallo, A Gutiérrez-Corrales, R Castillo-Oyague, J-L Gutiérrez-Perez, D Torres-Lagares
BACKGROUND: Head and neck cancer are one of the most common neoplasm pathologies in humans. The aim of this study was to analyze the type, characteristics, treatment and evolution of oral neoplasm or precancerous lesion in a sample of Andalusian population (Spain) derived from the Oncology Rehabilitation Hospital Unit during a period of 20 years. MATERIAL AND METHODS: A retrospective descriptive study was carried out during the years 1991 and 2011 analyzing the type, characteristics, treatment and follow-up of oral neoplasm in the Oral and Maxillofacial Surgery Unit of the Universitary Hospital Virgen del Rocio...
January 1, 2018: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29248948/secondary-metabolites-and-their-biological-activity-from-aspergillus-aculeatus-kku-ct2
#9
Natanong Yodsing, Ratsami Lekphrom, Watchara Sangsopha, Tadanori Aimi, Sophon Boonlue
The bioactive compounds of the fungus Aspergillus aculeatus strain KKU-CT2, have been studied. The crude extracts from this fungus showed good antimicrobial activity against human pathogens, including Gram-positive and Gram-negative bacteria and yeast-like fungi. Its chemical components were isolated and purified by chromatographic methods. The structures of the secondary metabolites were elucidated by spectroscopic methods (IR, 1H, and 13C NMR). They were identified as ergosterol peroxide (1), secalonic acid D (2), secalonic acid F (3), variecolin (4), variecolactone (5), and ergosterol (6)...
December 16, 2017: Current Microbiology
https://www.readbyqxmd.com/read/29245264/repeated-recurrent-epidermoid-cyst-with-atypical-hyperplasia-a-case-report-and-literature-review
#10
Jialin Li, Ming Qian, Xiaoyi Huang, Li Zhao, Xinghai Yang, Jianru Xiao
RATIONALE: Epidermoid cysts are slow-growing, benign tumor which account for less than 1% of all intraspinal tumors and epidermoid cyst with Atypical Hyperplasia is very rare. Surgical resection is the standard treatment of the tumor, but recurrence is not uncommon after incomplete resection. Inappropriate treatment can lead to repeated recurrent. Here, we reported a case of repeated recurrent epidermoid cyst with atypical hyperplasia treated with radiotherapy after surgery. PRESENTING CONCERNS: A 40-year-old female presenting with intraspinal epidermoid cyst showed incomplete paraplegia in lower limbs...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29239279/radiosensitization-by-cpg-odn7909-in-an-epidermoid-laryngeal-carcinoma-hep-2-cell-line
#11
Shu Wang, Xiaoqun Liu, Tiankui Qiao, Qi Zhang
Objective To evaluate the radiosensitivity effect of CpG oligodeoxyribonucleotide (ODN) 7909 on human epidermoid cancer strain-2 (Hep-2) cells in vitro and discuss the potential for improved radiotherapy treatment in patients with laryngeal squamous cell carcinoma. Methods Toll-like receptor ( TLR) 9 expression was assessed in Hep-2 cells using Western blots and reverse transcription polymerase chain reaction. Cell Counting Kit-8 was used to detect Hep-2 cell viability at 24 and 48 h following treatment with different CpG ODN7909 concentrations...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/29237498/vitreous-hemorrhage-and-rhegmatogenous-retinal-detachment-that-developed-after-botulinum-toxin-injection-to-the-extraocular-muscle-case-report
#12
Dong Hyun Lee, Jinu Han, Sueng-Han Han, Sung Chul Lee, Min Kim
BACKGROUND: The authors report a case of a rare complication that occurred after botulinum toxin injection to the extraocular muscle, which was easily overlooked and successfully corrected by surgery. CASE PRESENTATION: A 34-year-old female patient visited our clinic for diplopia and ocular motility disorder after removal of an epidermoid tumor of the brain. At her initial visit, her best-corrected visual acuity (BCVA) was 20/20 for both eyes. An alternate cover test showed 45 prism-diopter esotropia and 3 prism-diopter hypertropia in the right eye...
December 13, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/29230263/-kaposi-s-sarcoma-of-the-penis-in-a-hiv-seronegative-patient
#13
Mohammed Alae Touzani, Othmane Yddoussalah
Sarcomas of the penis account for less than 5% of all tumors of the penis. They are dominated by Kaposi's sarcoma that mainly affects HIV-positive patients. However, recent studies have shown a relationship between Kaposi's sarcoma and HHV-8 infection (Human herpes virus-8), which explains why this sarcoma occurs in non-immunocompromised and HIV-seronegative patients. We here report the case of a 72-year old patient, with no previous medical history, reporting of gradual onset of tumor-like granulation tissue of 3 years duration at the level of the gland, without secondary location...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29218653/differential-diagnosis-of-pancreatic-epidermoid-cyst-without-a-solid-component-residual-splenic-tissue-vs-mucinous-cystic-neoplasm
#14
Kousei Ishigami, Akihiro Nishie, Hiroyuki Irie, Yoshiki Asayama, Yasuhiro Ushijima, Yukihisa Takayama, Daisule Okamoto, Nobuhiro Fujita, Takao Ohtsuka, Tetsuhide Ito, Naoki Mochidome, Hiroshi Honda
PURPOSE: The purpose of this study was to clarify whether there are differences in imaging findings between pancreatic epidermoid cyst (EDC) without a solid component (residual splenic tissue) and mucinous cystic neoplasm (MCN). MATERIALS AND METHODS: The study group consisted of histologically proven EDC (eight cases) and MCN (20 cases). CT and MRI findings were compared on the following imaging findings: the shape of the cystic lesions and the presence or absence of septum, calcification, and high-intensity fluid on T1- and diffusion-weighted images (b factor = 1000)...
December 7, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29204203/intradiploic-pterional-epidermoid-tumor-a-case-report-and-review-of-literature
#15
Luis Rafael Moscote-Salazar, Guru Dutta Satyarthee, Willem Guillermo Calderon-Miranda, Amit Agrawal, Hernando Raphael Alvis-Miranda, Gabriel Alcala-Cerra, Alfonso Pacheco-Hernandez
Intradiploic epidermoid cyst is an uncommonly occurring neoplasm, and only about 200 cases are reported in the form of isolated case report. It is presumed to occur due to ectodermal cells in inclusion in the bone tissue during embryonic life neural tube closure. It commonly remains asymptomatic or rarely presents as a bony lump in the skull bone. Authors report present an interesting case, which presented with swelling, and underwent successful surgical resection. Pertinent literature along with diagnosis and management is briefly reviewed...
July 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/29191824/primary-cutaneous-mucoepidermal-carcinoma
#16
Mudita Gupta, Anchana Gulati, Kuldeep Verma, Archit Gupta
Mucoepidermal carcinoma (MEC) is a tumour having mixed components of mucus secreting and epidermoid cells. Salivary glands are the the most common site of origin. Primary cutaneous MEC is a rare presentation. We report a primary cutaneous MEC in a 98-year-old woman presenting a noduloulcerative lesion over the dorsum of the nose. Histopathology of the tumour showed nests of epidermoid cells with glandular differentiation and mucin production. The diagnosis was confirmed by immunohistochemistry.
November 29, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29184709/gamma-knife-radiosurgery-for-cerebellopontine-angle-epidermoid-tumors
#17
Amr M N El-Shehaby, Wael A Reda, Khaled M Abdel Karim, Reem M Emad Eldin, Ahmed M Nabeel
Background: Intracranial epidermoid tumors are commonly found in the cerebellopontine angle where they usually present with either trigeminal neuralgia or hemifacial spasm. Radiosurgery for these tumors has rarely been reported. The purpose of this study is to assess the safety and clinical outcome of the treatment of cerebellopontine epidermoid tumors with gamma knife radiosurgery. Methods: This is a retrospective study involving 12 patients harboring cerebellopontine angle epidermoid tumors who underwent 15 sessions of gamma knife radiosurgery...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/29182903/total-laparoscopic-splenectomy-for-giant-epidermoid-cyst-a-case-report
#18
P Lobascio, G Carbotta, R Laforgia, S Fedele, M G Sederino, M Minafra, A Delvecchio, F Ferrarese, N Palasciano
INTRODUCTION: Splenic cysts are benign tumors, accidentally detected using US or CT scan. They are classified into true cyst (primary, 25%) and pseudocyst (secondary, 75%). Conventional treatment of splenic cyst, especially giant, symptomatic and complicated has been open or laparoscopic total splenectomy. Recently, partial splenectomy is recommended as well to preserve its hematopoietic function and homeostasis of blood, but it is not considered safe for complications as intra and post operative bleeding...
July 2017: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/29169638/epidermoid-carcinoma-of-the-conjunctiva-associated-with-human-papillomavirus
#19
R E Valdez Sosa, G Vizcaino
No abstract text is available yet for this article.
November 20, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/29158862/-epidermoid-cyst-in-the-sella-turcica-about-a-case
#20
Ghizlane El Mghari, Bouchra Rafiq, Nawal El Ansari
Epidermoid cyst (EC) or cholesteatoma is a benign tumor, often of congenital origin, occurring in the sub-arachnoidian spaces. Its treatment is based on surgery. We report the case of a 38 year-old patient presenting with progressive intracranial hypertension syndrome associated with anterior pituitary insufficiency signs of the corticotropic, thyrotropic, gonadotropic axis occurring 1 year before. Brain MRI showed a craniopharyngioma. Anatomopathologic evaluation of the specimen showed epidermoid cyst.
2017: Pan African Medical Journal
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