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https://www.readbyqxmd.com/read/28430665/p2x7-receptor-and-nlrp3-inflammasome-activation-in-head-and-neck-cancer
#1
Ju Young Bae, Sang-Woo Lee, Yong-Hwan Shin, Jong-Ho Lee, Jeong Won Jahng, Kyungpyo Park
In this study, we investigated purinergic receptor P2X7 and NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome expressions, and their role in head and neck cancer. We found upregulation of purinergic receptor P2X7 and all NLRP3 inflammasome components in biopsied head and neck squamous cell carcinoma tissues. Similarly, the expression of purinergic receptor P2X7, apoptosis-associated speck-like protein containing CARD, and pro-form caspase 1 in A253 cells derived from epidermoid carcinoma were highly upregulated in comparison to normal Human Salivary Gland cell line...
April 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28427981/ultrastructure-of-pericystic-or-intracystic-blood-vessels-in-epidermoid-cysts-a-transmission-electron-microscopy-study-laboratory-investigation
#2
Xiao-Hui Ren, Jun Ma, Chun Zeng, Yi-Lin Sun, Song Lin
OBJECTIVES: Recently, we reported the tendency towards the spontaneous hemorrhage in both pre- and post-operative periods of patients with intracranial epidermoid cyst (EC). According to our experience this tendency of spontaneous hemorrhage was partly due to the pathologic blood vessels adjacent to the EC. This article was designed to testify this hypothesis. MATERIALS & METHODS: 23 removable pericystic or intracystic blood vessels from 17 EC patients were collected during surgery, and then were examined by transmission electron microscope...
April 17, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28425269/evaluation-of-cytotoxic-membrane-and-dna-damaging-effects-of-thymus-revolutus-c%C3%A3-lak-essential-oil-on-different-cancer-cells
#3
Aysun Özkan, Ayşe Erdoğan
BACKGROUND/AIM: In this study, we evaluated Thymus revolutus Célak essential oil and its two main constituents, γ-terpinene and p-cymene, as potential oxidative agents against lung cancer and epidermoid carcinoma cells. MATERIALS AND METHODS: Cell viability assessment was made by CellTiter-Blue1397904493 cell viability and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay after treatment with 5-600 μg/mL concentrations of essential oil, γ-terpinene, and p-cymene...
April 18, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28418236/a-novel-approach-of-using-near-infrared-responsive-pegylated-gold-nanorod-coated-poly-l-lactide-microneedles-to-enhance-the-antitumor-efficiency-of-docetaxel-loaded-mpeg-pdlla-micelles-for-treating-a431-tumor
#4
Ying Hao, MingLing Dong, TaoYe Zhang, JinRong Peng, YanPeng Jia, YiPing Cao, ZhiYong Qian
The combination of chemotherapy and photothermal therapy (PTT) plays a significant role in synergistic tumor therapy. However, high dosage of chemotherapy drugs or photothermal agents may cause series side effects. To overcome these challenges, we designed a near-infrared (NIR) responsive PEGylated gold nanorod (GNR-PEG) coated poly (L-lactide) microneedles (PLLA MNs) system (GNR-PEG@MNs) to enhance antitumor efficiency of docetaxel loaded MPEG-PDLLA (MPEG-PDLLA-DTX) micelles for treating A431 tumor. The as-made GNR-PEG@MNs contained only 31...
April 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28410628/laparoscopic-partial-splenectomy-for-a-splenic-epidermoid-cyst
#5
José M Ramia, Roberto de la Plaza Llamas, Aylhin Joana López-Marcano, José Del Carmen Valenzuela Torres, José Manuel García Gil
No abstract text is available yet for this article.
April 11, 2017: Cirugía Española
https://www.readbyqxmd.com/read/28409722/complete-endoscopic-resection-of-a-pituitary-stalk-epidermoid-cyst-using-a-combined-infrasellar-interpituitary-and-suprasellar-endonasal-approach-case-report
#6
Ana C I Nakassa, Joseph D Chabot, Carl H Snyderman, Eric W Wang, Paul A Gardner, Juan C Fernandez-Miranda
Intracranial epidermoid cysts are benign lesions of epithelial origin that most frequently present with symptoms of mass effect. Although they are often associated with a high rate of residual tumor and recurrence, maximal safe resection usually leads to good outcomes. The authors report a complete resection of an uncommon pituitary stalk epidermoid cyst with intrasellar extension using a combined suprasellar and infrasellar interpituitary, endoscopic endonasal transsphenoidal approach. The patient, a 54-year-old woman, presented with headache, visual disturbance, and diabetes insipidus...
April 14, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28387728/microvesicles-contribute-to-the-bystander-effect-of-dna-damage
#7
Xiaozeng Lin, Fengxiang Wei, Pierre Major, Khalid Al-Nedawi, Hassan A Al Saleh, Damu Tang
Genotoxic treatments elicit DNA damage response (DDR) not only in cells that are directly exposed but also in cells that are not in the field of treatment (bystander cells), a phenomenon that is commonly referred to as the bystander effect (BE). However, mechanisms underlying the BE remain elusive. We report here that etoposide and ultraviolet (UV) exposure stimulate the production of microvesicles (MVs) in DU145 prostate cancer cells. MVs isolated from UV-treated DU145 and A431 epidermoid carcinoma cells as well as etoposide-treated DU145 cells induced phosphorylation of ataxia-telangiectasia mutated (ATM) at serine 1981 (indicative of ATM activation) and phosphorylation of histone H2AX at serine 139 (γH2AX) in naïve DU145 cells...
April 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28378582/low-affinity-zinc-sensor-showing-fluorescence-responses-with-minimal-artifacts
#8
Xinhao Yan, Jin Ju Kim, Hye Sun Jeong, Yu Kyung Moon, Yoon Kyung Cho, Soyeon Ahn, Sang Beom Jun, Hakwon Kim, Youngmin You
The study of the zinc biology requires molecular probes with proper zinc affinity. We developed a low-affinity zinc probe (HBO-ACR) based on an azacrown ether (ACR) and an 2-(2-hydroxyphenyl)benzoxazole (HBO) fluorophore. This probe design imposed positive charge in the vicinity of a zinc coordination center, which enabled fluorescence turn-on responses to high levels of zinc without being affected by the pH and the presence of other transition-metal ions. Steady-state and transient photophysical investigations suggested that such a high tolerance benefits from orchestrated actions of proton-induced nonradiative and zinc-induced radiative control...
April 5, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28360959/a-case-of-epidermoid-median-raphe-cyst-traversing-the-corpora-cavernosa
#9
Alice Yu, John-Paul Capolicchio
Median raphe cysts are congenital lesions that typically have a superficial appearance. We present a very unusual case of a deep perineal mass in a six-year-old boy. The lesion extends into the corpus cavernosum, suggesting that the anomaly was an early embryological event. Histopathological features are consistent with an epidermoid type of median raphe cyst.
March 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28344047/sub-additive-effects-of-photodynamic-therapy-combined-with-erlotinib-for-the-treatment-of-epidermoid-carcinoma-an-in-vitro-study
#10
Sávio M L Gontijo, Renata C Felizali, Pedro P G Guimarães, Robson A S Santos, Rubén D Sinisterra, Maria E Cortés, Patrícia V Araújo
BACKGROUND: Photodynamic therapy (PDT) is an antitumour treatment that employs the combination of a photosensitive compound, oxygen and visible light. To improve the antitumour activity of PDT, the present study used the strategy of combining PDT with erlotinib (ERL), a drug frequently used in the treatment of epidermoid carcinoma. METHODS: An MTT cell viability assay was used to evaluate the cytotoxicity of PDT combined with ERL on A431 epidermoid carcinoma cells in vitro...
March 23, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28342703/intracranial-white-epidermoid-cyst-with-dystrophic-calcification-a-case-report-and-literature-review
#11
REVIEW
Krishnan Ravindran, Te Whiti Rogers, Tanya Yuen, Frank Gaillard
White epidermoids are a rare variant of an intracranial epidermoid cyst that do not exhibit typical 'near- cerebrospinal fluid (CSF)' CT density or MRI intensity. Here, the authors present the case of a 58year old man with an acute onset of aphasia and altered consciousness, due to a large heterogeneous cranial mass in the left frontal region with unusual signal intensity. Subsequent histopathological analysis identified the lesion as an epidermoid cyst.
March 22, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28315499/evaluation-of-the-decision-making-process-in-the-conservative-approach-to-small-testicular-masses
#12
Andrea Benelli, Virginia Varca, Lorenzo Derchi, Andrea Gregori, Giorgio Carmignani, Alchiede Simonato
INTRODUCTION: We evaluate the clinical outcome of patients treated with conservative approach for small testicular masses (STMs). We analyzed the steps who brought to the selection of the therapeutic approach: starting from clinical presentation, through imaging and lab studies. METHODS: We considered 18 patients who underwent an organ-sparing approach for STMs from 2005 until 2014. The selection criteria were dimension of the mass and absence of clinical, laboratory and/or radiological malignancy suspicion...
March 15, 2017: Urologia
https://www.readbyqxmd.com/read/28301021/cytotoxic-effect-of-thymus-caramanicus-jalas-on-human-oral-epidermoid-carcinoma-kb-cells
#13
Reza Fekrazad, Mehrad Afzali, Hamzeh Pasban-Aliabadi, Saeed Esmaeili-Mahani, Maryam Aminizadeh, Ali Mostafavi
Identifying new chemotherapeutic agents with fewer side effects is a major concern for scientists today. Thymus caramanicus Jalas (Lamiaceae family) is one of the species of Thymus that grows wild in different regions of Iran. Traditionally, leaves of this plant are used in the treatment of diabetes, arthritis and cancer. Here was investigated the cytotoxic property of Thymus caramanicus essential oil and extract in human oral epidermoid carcinoma KB cells. Cell viability was measured by MTT and neutral red assays...
January 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/28300686/epidermoid-cyst-in-an-intrapancreatic-accessory-spleen-diagnosed-by-typical-radiographic-images-and-endoscopic-ultrasound-fine-needle-aspiration-findings-with-contrast-agent
#14
Kazuyuki Matsumoto, Hironari Kato, Hiroyuki Okada
No abstract text is available yet for this article.
March 12, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28299308/malignant-transformation-of-an-intracranial-extradural-epidermoid-cyst-into-squamous-cell-carcinoma-presented-with-cerebrospinal-fluid-leakage
#15
Bahram Seif, Reza Pourkhalili, Ahmad Shekarchizadeh, Parvin Mahzouni
We report a case of malignant transformation of an intracranial extradural epidermoid cyst into squamous cell carcinoma (SCC), that presented with cerebrospinal fluid (CSF) leakage at the time of recurrence. Intracranial epidermoid cysts are histologically benign and slow-growing neoplasms. They are congenital lesions that develop from ectodermal remnants during neuroembryogenesis. Malignant transformation of epidermoid cysts into SCC is very rare. Various clinical presentations of these tumors after malignant transformation are mentioned in the literature...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28291963/in-vitro-cell-death-discrimination-and-screening-method-by-simple-and-cost-effective-viability-analysis
#16
Katharina Helm, Marlena Beyreis, Christian Mayr, Markus Ritter, Martin Jakab, Tobias Kiesslich, Kristjan Plaetzer
BACKGROUND/AIMS: For in vitro cytotoxicity testing, discrimination of apoptosis and necrosis represents valuable information. Viability analysis performed at two different time points post treatment could serve such a purpose because the dynamics of metabolic activity of apoptotic and necrotic cells is different, i.e. a more rapid decline of cellular metabolism during necrosis whereas cellular metabolism is maintained during the entire execution phase of apoptosis. This study describes a straightforward approach to distinguish apoptosis and necrosis...
February 21, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28287740/mediating-passive-tumor-accumulation-through-particle-size-tumor-type-and-location
#17
Jillian L Perry, Kevin G Reuter, J Christopher Luft, Chad V Pecot, William C Zamboni, Joseph M DeSimone
As the enhanced permeation and retention (EPR) effect continues to be a controversial topic in nanomedicine, we sought to examine EPR as a function of nanoparticle size, tumor model and tumor location, while also evaluating tumors for EPR mediating factors such as microvessel density, vascular permeability, lymphatics, stromal content, and tumor associated immune cells. Tumor accumulation was evaluated for 55x60 nm, 80x180 nm, and 80x320 nm PRINT particles, in four subcutaneous flank tumor models (SKOV3 human ovarian, 344SQ murine non-small cell lung, A549 human non-small cell lung, and A431 human epidermoid cancer)...
March 13, 2017: Nano Letters
https://www.readbyqxmd.com/read/28272655/histopathological-diagnostic-dilemma-in-retrorectal-developmental-cysts-report-of-a-case-and-review-of-the-literature
#18
Meltem Azatçam, Eren Altun, Veli Avci
Retrorectal developmental cysts are lesions that are classified according to their histopathological characteristics and origins. The major types are epidermoid cyst, dermoid cyst, rectal duplication cyst, rectal cystic hamartoma and teratoma. These cysts grow slowly and the majority of cases are asymptomatic. Total excision is required and histopathological examination should be carefully performed for retrorectal localized developmental cysts, since the cystic lesions may show malignant transformation. Here, a 3-year-old male patient with retrorectal mass, which was histopathologically compatible with tailgut cyst, is presented and the differential diagnosis of retrorectal developmental cysts is discussed...
February 4, 2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28219646/primary-squamous-cell-carcinoma-of-the-thyroid-initial-assessment-and-follow-up-using-18-f-fdg-pet-ct
#19
L Caballero Gullón, E Carmona González, A Martínez Estévez, M P Gómez Camarero, J J Corral, I Borrego Dorado
Squamous cell carcinoma of thyroid is an uncommon, very aggressive neoplasm, having a poor prognosis and poor response to chemotherapy and radiotherapy. Surgery is the initial treatment of choice, although it often presents as a widespread disease at the time of diagnosis, usually with cervical swelling that causes most of the symptoms due to local infiltration or metastasis. Local infiltration from adjacent tumour and metastatic disease needs to be excluded from other primary epidermoid carcinomas, in order to make a correct diagnosis...
February 16, 2017: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/28218467/divergent-roles-of-p120-catenin-isoforms-linked-to-altered-cell-viability-proliferation-and-invasiveness-in-carcinogen-induced-rat-skin-tumors
#20
Rong Wang, Ying-Shiuan Chen, Wan-Mohaiza Dashwood, Qingjie Li, Christiane V Löhr, Kay Fischer, Emily Ho, David E Williams, Roderick H Dashwood
The heterocyclic amine 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) targets multiple organs for tumorigenesis in the rat, including the colon and the skin. PhIP-induced skin tumors were subjected to mutation screening, which identified genetic changes in Hras (7/40, 17.5%) and Tp53 (2/40, 5%), but not in Ctnnb1, a commonly mutated gene in PhIP-induced colon tumors. Despite the absence of Ctnnb1 mutations, β-catenin was overexpressed in nuclear and plasma membrane fractions from PhIP-induced skin tumors, coinciding with loss of p120-catenin from the plasma membrane, and the appearance of multiple p120-catenin-associated bands in the nuclear extracts...
February 20, 2017: Molecular Carcinogenesis
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