keyword
MENU ▼
Read by QxMD icon Read
search

Treatment-resistant Depression

keyword
https://www.readbyqxmd.com/read/29912788/maintenance-ketamine-therapy-for-treatment-resistant-depression
#1
Shaina Archer, Carson Chrenek, Jennifer Swainson
BACKGROUND: Previous studies have demonstrated ketamine to have a rapid antidepressant effect in some patients with treatment-resistant depression (TRD), but the effect is unfortunately not sustained in the long term. In this study, we report on the clinical use of ongoing maintenance ketamine infusions in a group of patients with TRD, beyond an acute course of 6 to 8 ketamine infusions. METHODS: This retrospective case series reports on 11 patients with TRD who received maintenance ketamine infusions, defined as treatments beyond an initial series of up to 8 infusions...
June 14, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29910727/caffeine-and-selective-adenosine-receptor-antagonists-as-new-therapeutic-tools-for-the-motivational-symptoms-of-depression
#2
REVIEW
Laura López-Cruz, John D Salamone, Mercè Correa
Major depressive disorder is one of the most common and debilitating psychiatric disorders. Some of the motivational symptoms of depression, such anergia (lack of self-reported energy) and fatigue are relatively resistant to traditional treatments such as serotonin uptake inhibitors. Thus, new pharmacological targets are being investigated. Epidemiological data suggest that caffeine consumption can have an impact on aspects of depressive symptomatology. Caffeine is a non-selective adenosine antagonist for A1 /A2A receptors, and has been demonstrated to modulate behavior in classical animal models of depression...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29910467/gut-microbiota-modulate-neurobehavior-through-changes-in-brain-insulin-sensitivity-and-metabolism
#3
Marion Soto, Clémence Herzog, Julian A Pacheco, Shiho Fujisaka, Kevin Bullock, Clary B Clish, C Ronald Kahn
Obesity and diabetes in humans are associated with increased rates of anxiety and depression. To understand the role of the gut microbiome and brain insulin resistance in these disorders, we evaluated behaviors and insulin action in brain of mice with diet-induced obesity (DIO) with and without antibiotic treatment. We find that DIO mice have behaviors reflective of increased anxiety and depression. This is associated with decreased insulin signaling and increased inflammation in in the nucleus accumbens and amygdala...
June 18, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29910145/therapeutic-impact-of-motor-cortex-rtms-in-patients-with-chronic-neuropathic-pain-even-in-the-absence-of-an-analgesic-response-a-case-report
#4
Hasan Hodaj, Jean-François Payen, Jean-Pascal Lefaucheur
OBJECTIVE: To show that repetitive transcranial magnetic stimulation (rTMS) delivered at high frequency over the motor cortex can improve patients with chronic pain syndrome even if this procedure does not provide an analgesic response. CASE REPORT: A 77-year-old woman presented with drug-resistant chronic neuropathic pain affecting both lower limbs due to segmental spine compression at T9-T10 level. She underwent an rTMS protocol with an induction phase of 12 rTMS sessions during three weeks and a maintenance phase of 3 additional rTMS sessions for 5 weeks...
June 14, 2018: Neurophysiologie Clinique, Clinical Neurophysiology
https://www.readbyqxmd.com/read/29908347/aging-related-functional-and-structural-changes-in-the-heart-and-aorta-mitotempo-improves-aged-cardiovascular-performance
#5
Yusuf Olgar, Sinan Degirmenci, Aysegul Durak, Deniz Billur, Belgin Can, Gizem Kayki Mutlu, Ebru Arioglu Inan, Belma Turan
Aging in humans represents declining in cardio-protective systems, however its mechanisms are not known yet. We aimed to analyse how aging affects key mechanisms responsible for contractile dysfunction via comparing the improperly synchrony between electrical and mechanical activities in male aged-rats (24-month old) comparison to those of adult-rats (6-month old). We determined significantly increased systemic oxidative stress with decreased antioxidant capacity, clear insulin resistance and hypertrophy in aged-rats with normal fasting blood glucose...
June 13, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29903051/rapid-antidepressant-effects-of-the-psychedelic-ayahuasca-in-treatment-resistant-depression-a-randomized-placebo-controlled-trial
#6
Fernanda Palhano-Fontes, Dayanna Barreto, Heloisa Onias, Katia C Andrade, Morgana M Novaes, Jessica A Pessoa, Sergio A Mota-Rolim, Flávia L Osório, Rafael Sanches, Rafael G Dos Santos, Luís Fernando Tófoli, Gabriela de Oliveira Silveira, Mauricio Yonamine, Jordi Riba, Francisco R Santos, Antonio A Silva-Junior, João C Alchieri, Nicole L Galvão-Coelho, Bruno Lobão-Soares, Jaime E C Hallak, Emerson Arcoverde, João P Maia-de-Oliveira, Dráulio B Araújo
BACKGROUND: Recent open-label trials show that psychedelics, such as ayahuasca, hold promise as fast-onset antidepressants in treatment-resistant depression. METHODS: To test the antidepressant effects of ayahuasca, we conducted a parallel-arm, double-blind randomized placebo-controlled trial in 29 patients with treatment-resistant depression. Patients received a single dose of either ayahuasca or placebo. We assessed changes in depression severity with the Montgomery-Åsberg Depression Rating Scale (MADRS) and the Hamilton Depression Rating scale at baseline, and at 1 (D1), 2 (D2), and 7 (D7) days after dosing...
June 15, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29899972/ketamine-and-rapid-acting-antidepressants-a-new-era-in-the-battle-against-depression-and-suicide
#7
REVIEW
Ronald S Duman
Therapeutic medications for the treatment of depression have serious limitations, particularly delayed onset and low rates of efficacy. However, the discovery that a single subanesthetic dose of ketamine, a glutamate NMDA receptor channel blocker, can produce a rapid (within hours) antidepressant response that is sustained (about 1 week), even in patients considered treatment-resistant, has invigorated the field. In addition to these remarkable actions, ketamine has proven effective for the treatment of suicidal ideation...
2018: F1000Research
https://www.readbyqxmd.com/read/29898284/a-within-subject-consideration-of-the-psychotic-spectrum-disorder-concept-in-a-patient-in-remission-associated-with-cortical-gray-matter-recovery
#8
Herbert Y Meltzer, Min Young Sim, Adam Anderson, Christopher Cannistraci, Karu Jayathilake, Daniel Barrett Share, Myung Lee
INTRODUCTION: Psychotic spectrum disorder (PSD) links the syndromes of bipolar disorder, psychotic depression, and schizophrenia, often viewed as unique disorders. AIMS: Application of the PSD concept to a single patient rather than across groups of patients and demonstration of a remarkable remission of schizophrenia phenotype with recovery of gray matter in specific brain regions. RESULTS: We report a woman who experienced discrete, nonoverlapping periods of each of the above syndromes, in the order noted, over a 30-year period, followed by abrupt ending of psychosis and full remission lasting at least 7 years...
July 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29895202/the-effect-of-route-of-administration-on-the-enantioselective-pharmacokinetics-of-ketamine-and-norketamine-in-rats
#9
Martin Le Nedelec, Paul Glue, Helen Winter, Chelsea Goulton, Natalie J Medlicott
BACKGROUND: Ketamine has been shown to produce a rapid and potent antidepressant response in patients with treatment-resistant depression. Currently ketamine is most commonly administered as a 40-minute intravenous infusion, though it is unknown whether this is the optimal route of administration. AIMS: To determine the plasma concentration time course of the R- and S-enantiomers of ketamine and norketamine following administration of ketamine by four different routes of administration...
June 1, 2018: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29887302/-treatment-resistant-depression-and-antidepressant-plasma-level-proposal-of-a-pharmacogenetic-integrative-algorithm-from-a-case-report
#10
A Bourla, E Chaneac, F Ferreri
No abstract text is available yet for this article.
June 7, 2018: L'Encéphale
https://www.readbyqxmd.com/read/29884778/carbamoylated-erythropoietin-modulates-cognitive-outcomes-of-social-defeat-and-differentially-regulates-gene-expression-in-the-dorsal-and-ventral-hippocampus
#11
Monica Sathyanesan, Michael J Watt, Jacob M Haiar, Jamie L Scholl, Shaydel R Davies, Riley T Paulsen, Jayme Wiederin, Pawel Ciborowski, Samuel S Newton
Cognitive deficits are widespread in psychiatric disorders and frequently as debilitating as the affective component. Widely prescribed antidepressants for treating depressive disorders have limited efficacy in normalizing cognitive function. Erythropoietin (Epo) has been shown to improve cognitive function in schizophrenia and treatment resistant depressed patients. However, the potent elevation of red blood cell counts by Epo can cause hematological complications in non-anemic patients. We investigated a chemically engineered, posttranslational modification of Epo, carbamoylation, which renders it non-erythropoietic...
June 8, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29884653/international-union-of-basic-and-clinical-pharmacology-civ-the-neurobiology-of-treatment-resistant-depression-from-antidepressant-classifications-to-novel-pharmacological-targets
#12
F Caraci, F Calabrese, R Molteni, L Bartova, M Dold, G M Leggio, C Fabbri, J Mendlewicz, G Racagni, S Kasper, M A Riva, F Drago
Major depressive disorder is one of the most prevalent and life-threatening forms of mental illnesses and a major cause of morbidity worldwide. Currently available antidepressants are effective for most patients, although around 30% are considered treatment resistant (TRD), a condition that is associated with a significant impairment of cognitive function and poor quality of life. In this respect, the identification of the molecular mechanisms contributing to TRD represents an essential step for the design of novel and more efficacious drugs able to modify the clinical course of this disorder and increase remission rates in clinical practice...
July 2018: Pharmacological Reviews
https://www.readbyqxmd.com/read/29880069/effects-of-erythropoietin-on-body-composition-and-fat-glucose-metabolism-in-patients-with-affective-disorders
#13
Maj Vinberg, Pernille Højman, Bente Klarlund Pedersen, Lars Vedel Kessing, Kamilla W Miskowiak
BACKGROUND: Erythropoietin (EPO) has been suggested to improve metabolism and also cognition, but human studies are scarce. This randomised controlled trial aimed to investigate whether EPO treatment influences body composition and fat and glycated haemoglobin (HbA1c) and fasting glucose, and whether these changes would be associated with previous observed cognitive benefits of EPO. METHOD: In total, 84 non-obese patients with treatment-resistant unipolar depression or bipolar disorder in remission were randomised to 8 weekly EPO (40,000 IU) or saline (NaCl 0...
June 8, 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29879133/predictive-modeling-of-treatment-resistant-depression-using-data-from-star-d-and-an-independent-clinical-study
#14
Zhi Nie, Srinivasan Vairavan, Vaibhav A Narayan, Jieping Ye, Qingqin S Li
Identification of risk factors of treatment resistance may be useful to guide treatment selection, avoid inefficient trial-and-error, and improve major depressive disorder (MDD) care. We extended the work in predictive modeling of treatment resistant depression (TRD) via partition of the data from the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) cohort into a training and a testing dataset. We also included data from a small yet completely independent cohort RIS-INT-93 as an external test dataset...
2018: PloS One
https://www.readbyqxmd.com/read/29873959/incidence-of-risk-factors-for-and-changes-over-time-in-treatment-resistant-depression-in-denmark-a-register-based-cohort-study
#15
Frederikke Hordam Gronemann, Martin B Jorgensen, Merete Nordentoft, Per K Andersen, Merete Osler
OBJECTIVE: Varying definitions of treatment-resistant depression (TRD) across studies make it difficult to estimate the size of the problem and to identify patients at increased risk. The aim of this cohort study was to examine the incidence of TRD, disease-related risk factors, and changes over time using different definitions of TRD. METHODS: From 1996 through 2014, all patients with a first-time hospital contact for depression (ICD-10 codes F32 and F33) were identified in Danish National Patient Registries...
May 29, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29870432/long-term-sustained-cognitive-benefits-of-vagus-nerve-stimulation-in-refractory-depression
#16
Véronique Desbeaumes Jodoin, François Richer, Jean-Philippe Miron, Marie-Pierre Fournier-Gosselin, Paul Lespérance
BACKGROUND: Treatment-resistant depression (TRD) is a serious chronic condition disabling patients functionally and cognitively. Chronic vagus nerve stimulation (VNS) is recognized for the management of TRD, but few studies have examined its long-term effects on cognitive dysfunction in unipolar and bipolar resistant depression. OBJECTIVE: The purpose of this study was to assess the course of cognitive functions and clinical symptoms in a cohort of patients treated with VNS for TRD...
June 4, 2018: Journal of ECT
https://www.readbyqxmd.com/read/29869405/adjunctive-thyroid-hormone-treatment-in-rapid-cycling-bipolar-disorder-a-double-blind-placebo-controlled-trial-of-levothyroxine-l-t-4-and-triiodothyronine-t-3
#17
Patricia D Walshaw, Laszlo Gyulai, Michael Bauer, Mark S Bauer, Brian Calimlim, Catherine A Sugar, Peter C Whybrow
OBJECTIVES: This report describes the first comparative double-blind, placebo-controlled trial of levothyroxine (L-T4 ) and triiodothyronine (T3 ) as adjunctive treatments in rapid cycling bipolar disorder. METHODS: Thirty-two treatment-resistant, rapid cycling patients who had failed a trial of lithium were randomized into three treatment arms: L-T4 , T3 , or placebo. They were followed for ≥4 months with weekly clinical and endocrine assessments. RESULTS: There were no statistically significant differences between the groups in age, gender, duration of illness, or thyroid status...
June 4, 2018: Bipolar Disorders
https://www.readbyqxmd.com/read/29869197/cannabidiol-induces-rapid-and-sustained-antidepressant-like-effects-through-increased-bdnf-signaling-and-synaptogenesis-in-the-prefrontal-cortex
#18
Amanda J Sales, Manoela V Fogaça, Ariandra G Sartim, Vitor S Pereira, Gregers Wegener, Francisco S Guimarães, Sâmia R L Joca
Currently available antidepressants have a substantial time lag to induce therapeutic response and a relatively low efficacy. The development of drugs that addresses these limitations is critical to improving public health. Cannabidiol (CBD), a non-psychotomimetic component of Cannabis sativa, is a promising compound since it shows large-spectrum therapeutic potential in preclinical models and humans. However, its antidepressant properties have not been completely investigated. Therefore, the aims of this study were to investigate in male rodents (i) whether CBD could induce rapid and sustained antidepressant-like effects after a single administration and (ii) whether such effects could be related to changes in synaptic proteins/function...
June 4, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29867608/cortisol-modulation-by-ayahuasca-in-patients-with-treatment-resistant-depression-and-healthy-controls
#19
Ana C de Menezes Galvão, Raíssa N de Almeida, Erick A Dos Santos Silva, Fúlvio A M Freire, Fernanda Palhano-Fontes, Heloisa Onias, Emerson Arcoverde, João P Maia-de-Oliveira, Dráulio B de Araújo, Bruno Lobão-Soares, Nicole L Galvão-Coelho
Major depression is a highly prevalent mood disorder, affecting about 350 million people, and around 30% of the patients are resistant to currently available antidepressant medications. Recent evidence from a randomized controlled trial (RCT) supports the rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression. The aim of this study was to explore the effect of ayahuasca on plasma cortisol and awakening salivary cortisol response, in the same group of treatment-resistant patients (MD) and in healthy volunteers (C)...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29867368/nitrous-oxide-induces-prominent-cell-proliferation-in-adult-rat-hippocampal-dentate-gyrus
#20
Farah Chamaa, Hisham F Bahmad, Ahmad-Kareem Makkawi, Reda M Chalhoub, Elie D Al-Chaer, George B Bikhazi, Ziad Nahas, Wassim Abou-Kheir
The identification of distinct and more efficacious antidepressant treatments is highly needed. Nitrous oxide (N2 O) is an N-methyl-D-aspartic acid (NMDA) antagonist that has been reported to exhibit antidepressant effects in treatment-resistant depression (TRD) patients. Yet, no studies have investigated the effects of sub-anesthetic dosages of N2 O on hippocampal cell proliferation and neurogenesis in adult brain rats. In our study, adult male Sprague-Dawley rats were exposed to single or multiple exposures to mixtures of 70% N2 O and 30% oxygen (O2 )...
2018: Frontiers in Cellular Neuroscience
keyword
keyword
7313
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"