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https://www.readbyqxmd.com/read/29474520/stability-indicating-rp-hplc-method-for-estimation-of-potential-impurities-in-ledipasvir-and-characterization-of-a-new-degradation-impurity
#1
R Siva Kumar, K V Sravan Kumar, L Kondareddy, K R Yogeshwara, Gangrade Manish, Jayachandran Jeenet, Kanyawar Nitesh
A new sensitive and stability indicating reverse phase high-performance liquid chromatography method has been developed for the quantitative determination of potential impurities of Ledipasvir, active pharmaceutical ingredient. Efficient chromatographic separation was achieved on waters × select column contains C18 stationary phase in gradient mode, quantitation at wavelength of 325 nm and mobile phase A is 50 mM ammonium formate pH 3.5 and mobile phase B is acetonitrile with flow rate 1.2 mL. The method was validated according to International Council for Hormonisation guideline, linearity studies has shown correlation coefficient value greater than 0...
February 21, 2018: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/29474304/macular-microvascular-networks-in-healthy-pediatric-subjects
#2
Enrico Borrelli, Marcela Lonngi, Siva Balasubramanian, Tudor C Tepelus, Elmira Baghdasaryan, Nicholas A Iafe, Stacy L Pineles, Federico G Velez, David Sarraf, SriniVas R Sadda, Irena Tsui
PURPOSE: To report optical coherence tomography angiography (OCTA) values in healthy pediatric eyes and to identify factors that may modify these values. METHODS: In this prospective observational cross-sectional study, macular OCTA images were acquired from healthy pediatric patients. Main outcome measures were 1) foveal avascular zone (FAZ) area at the level of the superficial retinal capillary plexus (SCP); 2) SCP and deep retinal capillary plexus (DCP) perfusion density (based on the area of vessels); 3) SCP and DCP vessel density (based on a map with vessels of 1-pixel width); and 4) CC perfusion density...
February 22, 2018: Retina
https://www.readbyqxmd.com/read/29473490/identification-and-analysis-of-key-residues-involved-in-folding-and-binding-of-protein-carbohydrate-complexes
#3
Michael Gromiha, N R Siva Shanmugam, J Fermin Angelo Selvin, K Veluraja
Protein-carbohydrate interactions play vital roles in several biological processes in living organisms. The comparative analysis of binding site residues along with stabilizing residues in protein-carbohydrate complexes provides ample insights to understand the structure, function and recognition mechanism. In this work, we have identified 2.45% binding site residues in a non-redundant dataset of 1130 complexes using distance-based criteria and 7.07% stabilizing residues using the concepts of hydrophobicity, long-range interactions and conservation of residues...
February 21, 2018: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29468817/urinary-excretion-of-niacin-metabolites-in-humans-after-coffee-consumption
#4
Jonathan Isaak Kremer, Katharina Gömpel, Tamara Bakuradze, Gerhard Eisenbrand, Elke Richling
SCOPE: Coffee is a major natural source of niacin in the human diet, as it is formed during coffee roasting from the alkaloid trigonelline. The intention of our study was to monitor the urinary excretion of niacin metabolites after coffee consumption under controlled diet. METHODS AND RESULTS: We performed a four-day human intervention study on the excretion of major niacin metabolites in the urine of volunteers after ingestion of 500 mL regular coffee containing 34...
February 21, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29460864/serosurvey-of-coxiella-burnetii-in-high-risk-population-in-turkey-endemic-to-crimean-congo-haemorrhagic-fever-virus
#5
Rahşan Erturk, Ömer Poyraz, Turabi Güneş
Background & objectives: Q fever caused by Coxiella burnetii is a zoonotic infection that spreads to human beings from animals. This study was aimed to demographically examine the C. burnetii seroprevalence in the people living in villages where Crimean-Congo haemorrhagic fever virus (CCHFV) is endemic, in terms of various risk factors such as tick bites, tick contact, and occupational groups. Methods: A total of 440 serum samples from those living in rural areas of Sivas and Tokat regions in Turkey were included in the study as a risk group; 387of them were serologically CCHFV positive (as confirmed in our previous research)...
October 2017: Journal of Vector Borne Diseases
https://www.readbyqxmd.com/read/29452943/effect-of-episiotomy-training-with-beef-tongue-and-sponge-simulators-on-the-self-confidence-building-of-midwifery-students
#6
Handan Guler, Perihan Cetin, Zeliha Burcu Yurtsal, Busra Cesur, Mine Bekar, Tuba Uçar, Funda Evcili, Ali Cetin
This study assesses the efficacy of simulation-based episiotomy training (SBET) with beef tongue and sponge models in terms of the self confidence of midwifery students while performing episiotomy. Third-year midwifery students from Cumhuriyet University in the fall semesters of 2011 and 2012 were enrolled in the sponge and beef tongue model groups (n = 36 and n = 37, respectively). A checklist was prepared on the required skills for performing episiotomy which can be broken into three main parts, namely preparation, cutting and repairing and completion...
February 9, 2018: Nurse Education in Practice
https://www.readbyqxmd.com/read/29452269/progress-in-radiotherapy-for-regional-and-oligometastatic-disease-in-2017
#7
REVIEW
Suresh Senan, Chad G Rusthoven, Ben J Slotman, Shankar Siva
This review highlights key publications and abstracts in the field of radiation oncology for lung cancer in 2017, and attempts to place these in the context of developments for the broader thoracic oncology community.
February 13, 2018: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29448540/investigation-of-electrochemical-studies-of-magnesium-ion-conducting-poly-vinyl-alcohol-poly-vinyl-pyrrolidone-based-blend-polymers
#8
K Jeyabanu, V Siva, N Nallamuthu, S Selvanayagam, S Asath Bahadur, A Manikandan
Polymer blend electrolytes based on magnesium ion conducting PVA-PVP-MgCl2 polymer were prepared at different compositions by solution casting techniques. The prepared films were characterised by various techniques such as XRD and FTIR. Amorphous nature and structural coordination of polymer electrolyte were confirmed by X-ray diffraction and Fourier transform infrared spectroscopy studies. The ionic conductivity of the prepared polymer electrolytes were analysed through ac impedance spectroscopy. The highest conductivity was found to be in the order of ~10-6 Scm-1 at an ambient temperature for the composition of 50PVA:50PVP:5 wt% MgCl2...
February 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29438053/social-cues-trigger-differential-immune-investment-strategies-in-a-non-social-insect-tenebrio-molitor
#9
Joe D Gallagher, Michael T Siva-Jothy, Sophie E F Evison
Social immunization (SI) is a horizontal transfer of immunity that protects naive hosts against infection following exposure to infected nestmates. While mainly documented in eusocial insects, non-social species also share similar ecological features which favour the development of group-level immunity. Here, we investigate SI in Tenebrio molitor by pairing naive females with a pathogen-challenged conspecific for 72 h before measuring a series of immune and fitness traits. We found no evidence for SI, as beetles who cohabited with a live pathogen-challenged conspecific were not better protected against bacterial challenge...
February 2018: Biology Letters
https://www.readbyqxmd.com/read/29435472/cervical-spinal-cord-atrophy-an-early-marker-of-progressive-ms-onset
#10
Burcu Zeydan, Xinyi Gu, Elizabeth J Atkinson, B Mark Keegan, Brian G Weinshenker, Jan-Mendelt Tillema, Daniel Pelletier, Christina J Azevedo, Christine Lebrun-Frenay, Aksel Siva, Darin T Okuda, Kejal Kantarci, Orhun H Kantarci
Objective: To assess whether cervical spinal cord atrophy heralds the onset of progressive MS. Methods: We studied 34 individuals with radiologically isolated syndrome (RIS) and 31 patients with relapsing-remitting MS (RRMS) age matched to 25 patients within a year of onset of secondary progressive MS (SPMS). Two raters independently measured (twice per rater) the cervical spinal cord average segmental area (CASA) (mm2) of axial T2-weighted images between C2 and C7 landmarks...
March 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29427881/rapid-identification-of-limonoids-from-cipadessa-baccifera-and-xylocarpus-granatum-using-esi-q-tof-ms-ms-and-their-structure-fragmentation-study
#11
K Kumar, Bandi Siva, N Rama Rao, K Suresh Babu
Limonoids found to be chemotaxonomic markers from the plants of the Meliaceae and Rutaceae families. In the present study, rapid identification of limonoids from Cipadessa baccifera and Xylocarpus granatum were achieved using fast and simple electrospray ionization quadruple time-of-flight mass spectrometry (ESI-Q-ToF-MS/MS) in positive-ion mode. Although the structures of these compounds were found to be similar, Collision Induced Dissociation (CID) mass spectrometric analysis of these protonated/sodiated molecules indicated different fragmentation patterns by which the structures were confirmed...
December 27, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29426916/2-methoxyestradiol-protects-against-pressure-overload-induced-left-ventricular-hypertrophy
#12
Zaid H Maayah, Jody Levasseur, Ramanaguru Siva Piragasam, Ghada Abdelhamid, Jason R B Dyck, Richard P Fahlman, Arno G Siraki, Ayman O S El-Kadi
Numerous experimental studies have supported the evidence that 2-methoxyestradiol (2 ME) is a biologically active metabolite that mediates multiple effects on the cardiovascular system, largely independent of the estrogen receptor. 2 ME is a major cytochrome P450 1B1 (CYP1B1) metabolite and has been reported to have vasoprotective and anti-inflammatory actions. However, whether 2 ME would prevent cardiac hypertrophy induced by abdominal aortic constriction (AAC) has not been investigated yet. Therefore, the overall objectives of the present study were to elucidate the potential antihypertrophic effect of 2 ME and explore the mechanism(s) involved...
February 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29426477/the-effect-on-liveweight-gain-of-using-anthelmintics-with-incomplete-efficacy-against-resistant-cooperia-oncophora-in-cattle
#13
Paul M Candy, Tania S Waghorn, Chris M Miller, Siva Ganesh, Dave M Leathwick
A replicated field trial was conducted to measure the effect on liveweight gain of failing to adequately control anthelmintic resistant populations of Cooperia oncophora and to determine whether populations, and hence production losses, increased with time. Eight mobs of 10 Friesian-Hereford calves were run on independent farmlets from January to December, over each of two years. All mobs were routinely treated with a pour-on formulation of eprinomectin every six weeks, which controlled parasites other than Cooperia...
February 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29412996/probing-the-protein-protein-interaction-network-of-proteins-causing-maturity-onset-diabetes-of-the-young
#14
P Sneha, D Thirumal Kumar, Jose Lijo, M Megha, R Siva, C George Priya Doss
Protein-protein interactions (PPIs) play vital roles in various cellular pathways. Most of the proteins perform their responsibilities by interacting with an enormous number of proteins. Understanding these interactions of the proteins and their interacting partners has shed light toward the field of drug discovery. Also, PPIs enable us to understand the functions of a protein by understanding their interacting partners. Consequently, in the current study, PPI network of the proteins causing MODY (Maturity Onset Diabetes of the Young) was drawn, and their correlation in causing a disease condition was marked...
2018: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/29408008/takifugu-rubripes-cation-independent-mannose-6-phosphate-receptor-cloning-expression-and-functional-characterization-of-the-igf-ii-binding-domain
#15
A Ajith Kumar, Siva Kumar Nadimpalli
Mannose 6-phosphate/IGF-II receptor mediated lysosomal clearance of insulin like growth factor-II is significantly associated with the evolution of placental mammals. The protein is also referred to as the IGF-II receptor. Earlier studies suggested relatively low binding affinity between the receptor and ligand in prototherian and metatherian mammals. In the present study we cloned the IGF-II binding domain of the early vertebrate fugu fish and expressed it in bacteria. A 72000 Da truncated receptor containing the IGF-II binding domain was obtained...
January 30, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29397694/pressure-and-temperature-dependent-structural-studies-on-hollandite-type-ferrotitanate-and-crystal-structure-of-a-high-pressure-phase
#16
Samatha Bevara, S Nagabhusan Achary, Nandini Garg, Abhishek Chitnis, P U Sastry, A B Shinde, P Siva Ram Krishna, Avesh Kumar Tyagi
The structural stability and phase transition behavior of tetragonal (I4/m) hollandite type K2Fe2Ti6O16 have been investigated by in situ high pressure X-ray diffraction using synchrotron radiation and a diamond anvil cell as well as by variable temperature powder neutron and X-ray diffraction. The tetragonal phase is found to be stable in a wider range of temperatures, while it reversibly transforms to a monoclinic (I2/m) structure at a moderate pressure, viz. 3.6 GPa. The pressure induced phase transition occurs with only a marginal change in structural arrangements...
February 3, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29388943/corrigendum-reproductive-genetic-carrier-screening-for-cystic-fibrosis-fragile-x-syndrome-and-spinal-muscular-atrophy-in-australia-outcomes-of-12-000-tests
#17
Alison Dalton Archibald, Melanie Jane Smith, Trent Burgess, Katrina Louise Scarff, Justine Elliott, Clare Elizabeth Hunt, Caitlin Barns-Jenkins, Chelsea Holt, Karina Sandoval, Vanessa Siva Kumar, Lisa Ward, Emily Caroline Allen, Sarah Valerie Collis, Shannon Cowie, David Francis, Martin B Delatycki, Eppie Mildred Yiu, R John Massie, Mark Domenic Pertile, Desirée du Sart, Damien Bruno, David J Amor
This corrects the article DOI: 10.1038/gim.2017.134.
February 1, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29378558/cytotoxicity-of-seputhecarpan-d-thonningiol-and-12-other-phytochemicals-from-african-flora-towards-human-carcinoma-cells
#18
Victor Kuete, Dominique Ngnintedo, Ghislain W Fotso, Oğuzhan Karaosmanoğlu, Bonaventure T Ngadjui, Felix Keumedjio, Samuel O Yeboah, Kerstin Andrae-Marobela, Hülya Sivas
BACKGROUND: Despite the remarkable progress in cancer therapy in recent years, this disease still remains a serious public health concern. The use of natural products has been and continues to be one of the most effective ways to fight malignancies. The cytotoxicity of 14 compounds from African medicinal plants was evaluated in four human carcinoma cell lines and normal fibroblasts. The tested samples included: β-spinasterol (1), friedelanone (2), 16β-hydroxylupeol (3), β-amyrin acetate (4), lupeol acetate (5), sequoyitol (6), rhamnitrin (7), europetin 3-O-rhamnoside (8), thonningiol (9), glyasperin F (10), seputhecarpan B (11), seputhecarpan C (12), seputhecarpan D (13) and rheediaxanthone A (14)...
January 30, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29378178/limbal-stem-cell-deficiency-demography-and-underlying-causes
#19
Jayesh Vazirani, Dhanyasree Nair, Swapna Shanbhag, Siva Wurity, Abhishek Ranjan, Virender Sangwan
PURPOSE: To determine the demographic features of patients affected by limbal stem cell deficiency (LSCD), and to identify the underlying causes of LSCD DESIGN: Retrospective, multi-center case series SETTING: Two large tertiary care ophthalmology hospitals SUBJECTS: Patients with a diagnosis of LSCD presenting from January 1, 2005 to December 31, 2014 METHODS: Records of patients with a clinical diagnosis of LSCD were reviewed. Demographic details and clinical features at presentation, as well as the underlying cause of LSCD (if identified) were noted...
January 26, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29378129/hybrid-macrocycles-for-selective-binding-and-sensing-of-fluoride-in-aqueous-solution
#20
Aleksandr S Oshchepkov, Tatiana A Shumilova, Siva R Namashivaya, Olga A Fedorova, Pavel V Dorovatovskii, Victor N Khrustalev, Evgeny A Kataev
Synthesis and anion binding properties of hybrid macrocycles containing ammonium and hydrogen bond donor groups are reported. Receptor properties were studied in a 10 mM MES buffer solution at pH 6.2, at which the receptors carry two positive charges at the secondary amine groups. Receptor 1 was found to bind fluoride with the highest affinity (105 M-1) and selectivity among the synthesized receptors. It was the only receptor that demonstrated fluorescence increase upon addition of fluoride. Other titration experiments with halides and oxyanions led to an anion-induced aggregation and fluorescence quenching...
January 29, 2018: Journal of Organic Chemistry
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