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https://www.readbyqxmd.com/read/28512597/documentation-of-ethnomedicinal-information-and-antimicrobial-validation-of-thespesia-populnea-used-by-yanadi-tribe-of-ganugapenta-village-chittoor-district-andhra-pradesh-india
#1
Nataru Savithramma, Pulicherla Yugandhar, Pallipati Suvarnalatha Devi, Sade Ankanna, Damai Suhrulatha, Koya Siva Prasad, Ramakrishanan Ranjani, Nagoji Nagaraju, Kummara Madhava Chetty
AIM: This study aimed to document the traditional knowledge of medicinal plants and antimicrobial validation of Thespesia populnea used by Yanadi tribe of Chittoor district, Andhra Pradesh, India. MATERIALS AND METHODS: The study was mainly focused on documentation of medicinal plants used by Yanadi tribe to treat different diseases with a standard questionnaire. These plants were cross-checked in Dr. Dukes Database and available literature to know the significance of this tribe on medicinal knowledge...
April 2017: Journal of Intercultural Ethnopharmacology
https://www.readbyqxmd.com/read/28511405/evaluation-of-acute-oral-toxicity-of-ethanol-leaves-extract-of-catharanthus-roseus-in-wistar-albino-rats
#2
Venkateswar Rao Vutukuri, M C Das, Muralidhar Reddy, Siva Prabodh, Padma Sunethri
INTRODUCTION: Herbal drugs have gained importance globally in the treatment of various diseases. Catharanthus roseus is traditionally used as an anti diabetic and anti cancer drug. To the best of our knowledge limited data are available on acute and sub acute toxicity of C. roseus extract despite its wide spread use in traditional medicine. The present study was under taken to evaluate the acute oral toxicity of the ethanol leaves extract of C. roseus. AIM: To investigate the acute oral toxic effects of ethanol leaves extract of C...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28508231/role-of-the-aryl-hydrocarbon-receptor-in-carcinogenesis-and-potential-as-an-anti-cancer-drug-target
#3
REVIEW
Siva Kumar Kolluri, Un-Ho Jin, Stephen Safe
The aryl hydrocarbon receptor (AhR) was initially identified as the receptor that binds and mediates the toxic effects induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and structurally related halogenated aromatics. Other toxic compounds including some polynuclear aromatic hydrocarbons act through the AhR; however, during the last 25 years, it has become apparent that the AhR plays an essential role in maintaining cellular homeostasis. Moreover, the scope of ligands that bind the AhR includes endogenous compounds such as multiple tryptophan metabolites, other endogenous biochemicals, pharmaceuticals and health-promoting phytochemicals including flavonoids, indole-3-carbinol and its metabolites...
May 15, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28505604/nrf2-and-nf-%C3%AE%C2%BAb-modulation-by-plumbagin-attenuates-functional-behavioural-and-biochemical-deficits-in-rat-model-of-neuropathic-pain
#4
Vijay Arruri, Prashanth Komirishetty, Aparna Areti, Siva Kumar Naik Dungavath, Ashutosh Kumar
BACKGROUND: Plumbagin is known to exhibit a broad range of biological activities including anti-cancer, antimicrobial and has been widely used traditionally. Nuclear factor kappa-light-chain-enhancer of activated B-cells (NF-κB) inhibitory and Nuclear factor (erythroid derived-2) like-2 (Nrf2) modulatory activities of Plumbagin have been reported already. In nerve injury model of neuropathy in rats, the role of NF-κB upregulation and declined antioxidant defence has been well recognized...
February 27, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28498943/mycobacterium-tuberculosis-whole-genome-sequences-from-southern-india-suggest-novel-resistance-mechanisms-and-the-need-for-region-specific-diagnostics
#5
Abigail L Manson, Thomas Abeel, James E Galagan, Jagadish Chandrabose Sundaramurthi, Alex Salazar, Thies Gehrmann, Siva Kumar Shanmugam, Kannan Palaniyandi, Sujatha Narayanan, Soumya Swaminathan, Ashlee M Earl
Background.: India is home to 25% of all tuberculosis cases and the second highest number of multidrug resistant cases worldwide. However, little is known about the genetic diversity and resistance determinants of Indian Mycobacterium tuberculosis, particularly for the primary lineages found in India, lineages 1 and 3. Methods.: We whole genome sequenced 223 randomly selected M. tuberculosis strains from 196 patients within the Tiruvallur and Madurai districts of Tamil Nadu in Southern India...
June 1, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28495907/interdevice-comparison-of-retinal-sensitivity-assessments-in-a-healthy-population-the-centervue-maia-and-the-nidek-mp-3-microperimeters
#6
Siva Balasubramanian, Akihito Uji, Jianqin Lei, Swetha Velaga, Muneeswar Nittala, SriniVas Sadda
BACKGROUND: To compare and correlate the retinal sensitivity measurements obtained with Nidek Microperimetry-3 (MP-3) and the CenterVue Macular Integrity Assessment (MAIA) microperimeters among healthy subjects. METHODS: In this prospective comparative study, 31 eyes of 23 subjects underwent complete ophthalmological examination including retinal sensitivity assessments using two microperimeters, the MP-3 (Nidek Technologies) and the MAIA (CenterVue). The mean retinal sensitivity (dB) and its corresponding luminance (asb) and contrast (log units) were analysed between the two instruments...
May 11, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28492681/statistical-modelling-and-simulation-of-nanohybrid-shish-kebab-architecture-of-pe-b-peg-copolymers-and-carbon-nanotubes
#7
Tuan Le, Nina Collazos, Austin Simoneaux, Siva Murru, Dilip Depan, Ramalingam Subramaniam
Carbon nanotubes have been known to develop hierarchically ordered polymer nanocomposites by virtue of epitaxial crystallization. A unique product of CNT induced crystallization is generation of nanohybrid shish-kebab (NHSK) structure, which has gained tremendous attention owing to its unique applications. However, research faces major challenges in terms of producing tunable patterns on CNTs, which are largely governed by precise control of the crystallization parameters. Conventional methods of experimentation can mislead the effect of experimental conditions on NHSK structure...
May 11, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28492405/a-case-control-analysis-of-postoperative-fluid-balance-and-mortality-after-pediatric-cardiac-surgery
#8
Meth R Delpachitra, Siva P Namachivayam, Johnny Millar, Carmel Delzoppo, Warwick W Butt
OBJECTIVES: A positive fluid balance after cardiac surgery may be associated with poor outcomes; however, previous studies looking at this association have been limited by the number of deaths in the study population. Our primary aim was to determine the relationship between postoperative cumulative fluid balance and mortality in cardiac surgical patients. Secondary aims were to study the association between fluid balance and duration of mechanical ventilation, intensive care and hospital length of stay...
May 10, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28482219/new-cycloartane-type-triterpenoids-from-the-areal-parts-of-caragana-sukiensis-and-their-biological-activities
#9
S Divya Reddy, Bandi Siva, V S Phani Babu, M Vijaya, V Lakshma Nayak, Reeta Mandal, Ashok K Tiwari, P Shashikala, K Suresh Babu
A comprehensive re-investigation of aerial parts of Caragana sukiensis resulted in the isolation of twelve compounds (1-12) including three new cycloartane type triterpenoids (3-5) respectively. Chemical structures of the isolated compounds were established by analysis of their IR, HRMSESI, 1D and 2D NMR spectroscopic data. In addition, these compounds were evaluated for their cytotoxic activity against cancer lines (HeLa, A549, MCF-7, DU-145) and Human embryonic kidney cell line (HEK-293). The results indicated that compound 8 showed potent cytotoxic activity against A549 with IC50 value of 1...
April 24, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28476980/cytotoxic-potentials-of-biologically-fabricated-platinum-nanoparticles-from-streptomyces-sp-on-mcf-7-breast-cancer-cells
#10
Balraj Baskaran, Arulmozhi Muthukumarasamy, Siva Chidambaram, Abimanyu Sugumaran, Krithikadevi Ramachandran, Thaneswari Rasu Manimuthu
Biosynthesis of novel therapeutic nano-scale materials for biomedical and pharmaceutical applications has been enormously developed, since last decade. Herein, the authors report an ecological way of synthesising the platinum nanoparticles (PtNPs) using Streptomyces sp. for the first time. The produced PtNPs exhibited the face centred cubic system. The fourier transform infrared spectrum revealed the existence of amino acids in proteins which serves as an essential reductant for the formation of PtNPs. The spherical morphology of the PtNPs with an average size of 20-50 nm was observed from topographical images of atomic force microscopy and field emission scanning electron microscopy...
April 2017: IET Nanobiotechnology
https://www.readbyqxmd.com/read/28476961/poly-vinyl-alcohol-poly-acrylamide-co-diallyldimethyl-ammonium-chloride-semi-ipn-hydrogels-for-ciprofloxacin-hydrochloride-drug-delivery
#11
Siva Sankar Sana, Vijaya Kumar Naidu Boya
Herein, the authors developed a new and potential semi-interpenetrating polymer network (semi-IPN) hydrogels of poly vinyl alcohol (PVA), acryl amide and diallyldimethyl ammonium chloride employing chemical cross-linker N, N'-methylene bisacrylamide (NNMBA) and ammonium persulphate as an initiator by radical polymerisation. To analyse the copolymer formation between two monomers and IPN cross-linking reaction, the resulting hydrogel was characterised by Fourier transform infrared spectroscopy and the surface morphology was analysed using scanning electron microscopy...
February 2017: IET Nanobiotechnology
https://www.readbyqxmd.com/read/28475382/dysplasia-and-colorectal-cancer-surveillance-in-inflammatory-bowel-disease
#12
Samba Siva Reddy Pulusu, Ian C Lawrance
Inflammatory bowel disease (IBD) patients are at an increased risk of developing colorectal cancer (CRC), a devastating complication of which intestinal dysplasia is the precursor. Considerable progress has been made to determine CRC risk in IBD, identification & management of dysplasia and preventative methods. Traditionally, surveillance colonoscopies with random colonic biopsies was used. However recent data suggests that chromoendoscopy is a better method of surveillance. Using 5-aminosalicylic acid agents primarily for chemoprevention is an ongoing debate however, when prescribed along with other strategies to control inflammation, their use is considered of benefit...
May 5, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28471189/intermolecular-potentials-of-methane-assessed-by-second-virial-coefficients-ab-initio-dimer-interaction-energies-and-aggregate-cohesive-energies
#13
Douglas S Ribeiro
This study presents computations of three energy related properties for 26 previously published multisite intermolecular potentials of methane: MM2, MM3, MM2en, MM3en, MM2mc, MM3mc, MM3envir, RMK, OPLS all-atom, MUB-2, AMBER, BOYD, Williams, Sheikh, MG, Tsuzuki, E2-Gay, E4-Gay, MP4exp-6(iii), MP4exp-6(iv), Rowley-A, Rowley-B, TraPPE-EH, Ouyang, CLC, and Chao and three united atom potentials: Saager-Fischer (SF), OPLS united atom, and HFD. The three properties analyzed are the second virial coefficients for 14 temperature points in the range of 110 to 623...
May 19, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28471083/ethanol-as-a-hydrogenating-agent-palladium-catalyzed-stereoselective-hydrogenation-of-ynamides-to-give-enamides
#14
Alla Siva Reddy, K C Kumara Swamy
Ethanol is shown to act as a hydrogenating agent for ynamides under palladium catalysis. This behavior is different from the normally expected reaction of ethanol addition to alkynes. The reaction shows stereoselectivity for E enamides, which is in contrast to reports using other hydrogenating sources. The method was also extended to ynamines. Alternatively, the use of ethanol and ammonium formate as the hydrogenating source gives Z enamides. The role of ethanol in hydrogenation was demonstrated by means deuterium labeling experiment...
May 4, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28470458/a-simple-risk-prediction-algorithm-for-hiv-transmission-results-from-hiv-prevention-trials-in-kwazulu-natal-south-africa-2002-2012
#15
Handan Wand, Tarylee Reddy, Sarita Naidoo, Suri Moonsamy, Samantha Siva, Neetha S Morar, Gita Ramjee
We aimed to develop a HIV risk scoring algorithm for targeted screening among women in South Africa. We used data from five biomedical intervention trials (N = 8982 Cox regression models were used to create a risk prediction algorithm and it was internally and externally validated using standard statistical measures; 7-factors were identified as significant predictors of HIV infection: <25 years old, being single/not cohabiting, parity (<3), age at sexual debut (<16), 3+ sexual partners, using injectables and diagnosis with a sexually transmitted infection(s)...
May 3, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28462968/surveying-macrocyclic-chemistry-from-flexible-crown-ethers-to-rigid-cyclophanes
#16
REVIEW
Zhichang Liu, Siva Krishna Mohan Nalluri, J Fraser Stoddart
Macrocycles are molecular entities that display a combination of molecular recognition and complexation properties with vital implications for host-guest/supramolecular chemistry. Since the accidental discovery of the crown ethers by Pedersen half a century ago, the chemistry of wholly synthetic macrocycles for structure-specific, highly selective, host-guest complexation has experienced rapid development. While the structural diversity and host-guest chemistry of the original macrocycles are well-known, new derivatives of them are being investigated continuously and reported on today in order to improve their recognition properties as well as to unleash new opportunities in supramolecular chemistry...
May 9, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28457540/lymph-node-metastases-in-thymic-tumors-the-more-we-know-the-less-we-know
#17
EDITORIAL
Usman Ahmad, Siva Raja
No abstract text is available yet for this article.
April 3, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28454359/modeling-nasopharyngeal-carcinoma-in-three-dimensions
#18
Prabu Siva Sankar, Mohd Firdaus Che Mat, Kalaivani Muniandy, Benedict Lian Shi Xiang, Phang Su Ling, Susan Ling Ling Hoe, Alan Soo-Beng Khoo, Nethia Mohana-Kumaran
Nasopharyngeal carcinoma (NPC) is a type of cancer endemic in Asia, including Malaysia, Southern China, Hong Kong and Taiwan. Treatment resistance, particularly in recurring cases, remains a challenge. Thus, studies to develop novel therapeutic agents are important. Potential therapeutic compounds may be effectively examined using two-dimensional (2D) cell culture models, three-dimensional (3D) spheroid models or in vivo animal models. The majority of drug assessments for cancers, including for NPC, are currently performed with 2D cell culture models...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28439113/microrna-expression-profiling-defines-the-impact-of-electronic-cigarettes-on-human-airway-epithelial-cells
#19
Siva Kumar Solleti, Soumyaroop Bhattacharya, Ausaf Ahmad, Qian Wang, Jared Mereness, Tirumalai Rangasamy, Thomas J Mariani
While all forms of tobacco exposure have negative health effects, the significance of exposure to electronic cigarettes (eCig) is not fully understood. Here, we studied the global effects of eCig on the micro RNA (miRNA) transcriptome in human lung epithelial cells. Primary human bronchial epithelial (NHBE) cells differentiated at air-liquid interface were exposed to eCig liquid. Exposure of NHBE to any eCig liquid resulted in the induction of oxidative stress-response genes including GCLM, GCLC, GPX2, NQO1 and HO-1...
April 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28438647/effects-of-bms-902483-an-%C3%AE-7-nicotinic-acetylcholine-receptor-partial-agonist-on-cognition-and-sensory-gating-in-relation-to-receptor-occupancy-in-rodents
#20
Rick L Pieschl, Regina Miller, Kelli M Jones, Debra J Post-Munson, Ping Chen, Kimberly Newberry, Yulia Benitex, Thaddeus Molski, Daniel Morgan, Ivar M McDonald, John E Macor, Richard E Olson, Yukiko Asaka, Siva Digavalli, Amy Easton, James Herrington, Ryan S Westphal, Nicholas J Lodge, Robert Zaczek, Linda J Bristow, Yu-Wen Li
The α7 nicotinic acetylcholine receptor is thought to play an important role in human cognition. Here we describe the in vivo effects of BMS-902483, a selective potent α7 nicotinic acetylcholine receptor partial agonist, in relationship to α7 nicotinic acetylcholine receptor occupancy. BMS-902483 has low nanomolar affinity for rat and human α7 nicotinic acetylcholine receptors and elicits currents in cells expressing human or rat α7 nicotinic acetylcholine receptors that are about 60% of the maximal acetylcholine response...
April 22, 2017: European Journal of Pharmacology
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