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https://www.readbyqxmd.com/read/28818768/novel-gomisin-b-analogues-as-potential-cytotoxic-agents-design-synthesis-biological-evaluation-and-docking-studies
#1
B Poornima, Bandi Siva, A Venkanna, G Shankaraiah, Nishant Jain, Dharmendra Kumar Yadav, Sanjeev Misra, K Suresh Babu
As part of pharmacological-phytochemical integrated studies on medicinal flora, Gomisin B (1) was isolated as major phytochemical lead from schisandra grandiflora, a plant traditionally used in different Asian systems of medicine. A series of 1,2,3-triazoles derivatives were synthesized at the C-7' position of the gomisin B core through diastereoselective Michael addition followed by regioselective Huisgen 1,3-dipolar cycloaddition reactions. All these triazolyl derivatives (5a-5q) were well characterized using modern spectroscopic techniques and evaluated for their anti-cancer activity against a panel of five human cancerous cell-lines...
August 1, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28808575/reduced-ventilation-perfusion-v-q-mismatch-following-endobronchial-valve-insertion-demonstrated-by-gallium-68-v-q-photon-emission-tomography-computed-tomography
#2
Paul Leong, Pierre-Yves Le Roux, Jason Callahan, Shankar Siva, Michael S Hofman, Daniel P Steinfort
Endobronchial valves (EBVs) are increasingly deployed in the management of severe emphysema. Initial studies focussed on volume reduction as the mechanism, with subsequent improvement in forced expiratory volume in 1 s (FEV1). More recent studies have emphasized importance of perfusion on predicting outcomes, though findings have been inconsistent. Gallium-68 ventilation-perfusion (V/Q) photon emission tomography (PET)/computed tomography (CT) is a novel imaging modality with advantages in spatial resolution, quantitation, and speed over conventional V/Q scintigraphy...
September 2017: Respirology Case Reports
https://www.readbyqxmd.com/read/28806134/ilir-viral-a-web-resource-for-lir-motif-containing-proteins-in-viruses
#3
Anne-Claire Jacomin, Siva Samavedam, Hannah Charles, Ioannis P Nezis
Macroautophagy/autophagy has been shown to mediate the selective lysosomal degradation of pathogenic bacteria and viruses (xenophagy), and to contribute to the activation of innate and adaptative immune responses. Autophagy can serve as an antiviral defense mechanism but also as a pro-viral process during infection. Atg8-family proteins play a central role in the autophagy process due to their ability to interact with components of the autophagy machinery as well as selective autophagy receptors and adaptor proteins...
August 14, 2017: Autophagy
https://www.readbyqxmd.com/read/28801763/a-situational-analysis-of-breast-cancer-early-detection-services-in-trinidad-and-tobago
#4
Kimberly Badal, Fidel Rampersad, Wayne A Warner, Adetunji T Toriola, Hamish Mohammed, Harold-Alexis Scheffel, Rehanna Ali, Murrie Moosoodeen, Siva Konduru, Adaila Russel, Rajini Haraksingh
PURPOSE: A situational analysis of breast cancer (BC) early detection services was carried out to investigate whether Trinidad and Tobago (T&T) has the framework for successful organized national screening. METHODS: An online survey was designed to assess the availability, accessibility, quality control and assurance (QC&A), and monitoring and evaluation (M&E) mechanisms for public and private BC early detection. A focus group with local radiologists (n = 3) was held to identify unaddressed challenges and make recommendations for improvement...
August 11, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28800637/biologically-active-recombinant-human-erythropoietin-expressed-in-hairy-root-cultures-and-regenerated-plantlets-of-nicotiana-tabacum-l
#5
Poornima Devi Gurusamy, Holger Schäfer, Siva Ramamoorthy, Michael Wink
Hairy root culture is a potential alternative to conventional mammalian cell culture to produce recombinant proteins due to its ease in protein recovery, low costs and absence of potentially human pathogenic contaminants. The current study focussed to develop a new platform of a hairy root culture system from Nicotiana tabacum for the production of recombinant human EPO (rhEPO), which is regularly produced in mammalian cells. The human EPO construct was amplified with C-terminal hexahistidine tag from a cDNA of Caco-2 cells...
2017: PloS One
https://www.readbyqxmd.com/read/28789673/gene-and-transcript-abundances-of-bacterial-type-iii-secretion-systems-from-the-rumen-microbiome-are-correlated-with-methane-yield-in-sheep
#6
Janine Kamke, Priya Soni, Yang Li, Siva Ganesh, William J Kelly, Sinead C Leahy, Weibing Shi, Jeff Froula, Edward M Rubin, Graeme T Attwood
BACKGROUND: Ruminants are important contributors to global methane emissions via microbial fermentation in their reticulo-rumens. This study is part of a larger program, characterising the rumen microbiomes of sheep which vary naturally in methane yield (g CH4/kg DM/day) and aims to define differences in microbial communities, and in gene and transcript abundances that can explain the animal methane phenotype. METHODS: Rumen microbiome metagenomic and metatranscriptomic data were analysed by Gene Set Enrichment, sparse partial least squares regression and the Wilcoxon Rank Sum test to estimate correlations between specific KEGG bacterial pathways/genes and high methane yield in sheep...
August 8, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28783355/iminosugar-c-nitromethyl-glycosides-and-divergent-synthesis-of-bicyclic-iminosugars
#7
Sure Siva Prasad, Soundararasu Senthilkumar, Akriti Srivastava, Sundarababu Baskaran
An efficient one-pot method for the stereoselective synthesis of novel iminosugar C-nitromethyl glycosides is described. This new class of iminosugar glycosides has versatile nitromethyl functionality whose utility was further demonstrated in the single-step synthesis of bicyclic iminosugars. Under reagent-free conditions, the N-allyl-C-nitromethyl glycosides resulted in intramolecular cyclization to iminosugar-oximes, whereas under SET oxidation, they furnished cyclopropane-fused iminosugars. The N-propargyl-C-nitromethyl glycosides underwent an unprecedented ketenimine-acrylamidine-Michael addition cascade reaction to give bicyclic amidines...
August 7, 2017: Organic Letters
https://www.readbyqxmd.com/read/28772069/noninvasive-substitution-of-k-sites-in-cyclodextrin-metal-organic-frameworks-by-li-ions
#8
Hasmukh A Patel, Timur Islamoglu, Zhichang Liu, Siva Krishna Mohan Nalluri, Avik Samanta, Ommid Anamimoghadam, Christos D Malliakas, Omar K Farha, J Fraser Stoddart
Co-crystallization of K(+) and Li(+) ions with γ-cyclodextrin (γ-CD) has been shown to substitute the K(+) ion sites partially by Li(+) ions, while retaining the structural integrity and accessible porosity of CD-MOF-1 (MOF, metal-organic framework). A series of experiments, in which the K(+)/Li(+) ratio was varied with respect to that of γ-CD, have been conducted in order to achieve the highest possible proportion of Li(+) ions in the framework. Attempts to obtain a CD-MOF containing only Li(+) ions resulted in nonporous materials...
August 16, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28768727/manipulating-glucose-metabolism-during-different-stages-of-viral-pathogenesis-can-have-either-detrimental-or-beneficial-effects
#9
Siva Karthik Varanasi, Dallas Donohoe, Ujjaldeep Jaggi, Barry T Rouse
This report deals with physiological changes and their implication following ocular infection with HSV. This infection usually results in a blinding inflammatory reaction in the cornea, orchestrated mainly by proinflammatory CD4 T cells and constrained in severity by regulatory T cells. In the present report, we make the unexpected finding that blood glucose levels change significantly during the course of infection. Whereas levels remained normal during the early phase of infection when the virus was actively replicating in the cornea, they increased around 2-fold during the time when inflammatory responses to the virus was occurring...
August 2, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28760228/role-of-mass-spectrometry-in-clinical-endocrinology
#10
REVIEW
Siva S Ketha, Ravinder J Singh, Hemamalini Ketha
The advent of mass spectrometry into the clinical laboratory has led to an improvement in clinical management of several endocrine diseases. Liquid chromatography tandem mass spectrometry found some of its first clinical applications in the diagnosis of inborn errors of metabolism, in quantitative steroid analysis, and in drug analysis laboratories. Mass spectrometry assays offer analytical sensitivity and specificity that is superior to immunoassays for many analytes. This article highlights several areas of clinical endocrinology that have witnessed the use of liquid chromatography tandem mass spectrometry to improve clinical outcomes...
September 2017: Endocrinology and Metabolism Clinics of North America
https://www.readbyqxmd.com/read/28754514/comparative-efficacy-of-chemical-stabilizers-on-the-thermostabilization-of-a-novel-live-attenuated-buffalopox-vaccine
#11
M S Siva Sankar, V Bhanuprakash, G Venkatesan, D P Bora, M Prabhu, R Yogisharadhya
In the present investigation, the thermostability of a live attenuated buffalopox vaccine prepared with an indigenous baffalopox virus isolate (BPXV Vij/96) and freeze-dried under conventional lyophilizing conditions is described. Three different stabilizer combinations like LS (lactalbumin hydralysate + sucrose), LHT (lactalbumin hydralysate + Trehalose dihydrate) and TAA (Trehalose dihydrate + l- Alanine + l-Histidine) were used to prepare the vaccine. The study indicated that the LS stabilizer was found to be the stabilizer of choice followed by LHT and TAA for buffalopox vaccine at all temperatures studied...
July 25, 2017: Biologicals: Journal of the International Association of Biological Standardization
https://www.readbyqxmd.com/read/28754465/evaluation-of-pharmacokinetic-and-pharmacodynamic-profiles-of-liposomes-for-the-cell-type-specific-delivery-of-small-molecule-drugs
#12
Siva Sai Krishna Dasa, Ryo Suzuki, Emily Mugler, Lanlin Chen, Rasmus Jansson-Löfmark, Erik Michaëlsson, Lennart Lindfors, Alexander L Klibanov, Brent A French, Kimberly A Kelly
Liposome-based drug formulations represent an exciting avenue of research as they increase efficacy to toxicity ratios. Current formulations rely on passive accumulation to the disease site where drug is taken up by the cells. Ligand mediated targeting increases the net accumulation of liposomes, however, an unexplored benefit is to potentially refine pharmacodynamics (PD) of a drug specifically to different cell types within diseased tissue. As a model system, we engineered cardiomyocyte- (I-1) and endothelial-targeted (B-40) liposomes to carry a VEGFR2 inhibitor (PTK787), and examined the effect of cell type-specific delivery on both pharmacokinetics (PK) and PD...
July 25, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28753516/synthesis-molecular-modeling-studies-and-bronchodilation-properties-of-nicotinonitrile-containing-compounds
#13
E A Soliman, Siva S Panda, Marian N Aziz, ElSayed M Shalaby, Nawal Mishriky, Fahmy M Asaad, Adel S Girgis
Facile synthetic pathway for nicotinonitriles 5a‒o, 7a‒i was demonstrated through reaction of ketones 4a‒k, 6a‒f with ylidenemalononitrile 3 in the presence of sodium alkoxide. Meanwhile, nucleophilic attack of amines on 2-bromonicotinonitrile 9 (obtained through reaction of propenone 8 with malononitrile, followed by bromination with bromine in acetic acid) afforded 3-pyridinecarbonitriles 11a‒d. Single crystal X-ray of compound 7i reveals the monoclinic space group C2/c with 8 molecules per unit cell...
July 17, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28751939/a-comparative-assessment-of-postoperative-analgesic-efficacy-of-lornoxicam-versus-tramadol-after-open-reduction-and-internal-fixation-of-mandibular-fractures
#14
Ankesh Dilip Jain, Ravisankar Vsm, Siva Bharani Ksn, Sudheesh Km, Nisha Tewathia
Pain after any surgical procedure is inevitable but can be controlled by administration of analgesics in most cases. Postoperative pain after surgical treatment of mandibular fractures can be treated by nonsteroidal anti-inflammatory drugs (NSAIDs) and opioid analgesics. The purpose of this study is to critically compare the postoperative analgesic efficacy of small doses of intravenous TRAMADOL (opioid analgesic) versus LORNOXICAM (NSAID) in patients with mandibular trauma undergoing open reduction and internal fixation (ORIF) and to assess the presence of any adverse effects due to NSAID or opioid use...
September 2017: Craniomaxillofacial Trauma & Reconstruction
https://www.readbyqxmd.com/read/28751467/recurrent-thrombosis-in-patients-with-antiphospholipid-syndrome-receiving-newer-oral-anticoagulants-a-case-report-and-review-of-literature
#15
Akanksha Joshi, Jason Hong, Chokkalingam Siva
We present the case of a patient with primary APS who had a recurrence of thrombotic event while on treatment with rivaroxaban and had to be restarted on warfarin. The current literature on recurrence of thrombotic events in patients with antiphospholipid syndrome (APS) treated with newer oral anticoagulants (NOAC) is also reviewed. Relevant case reports and case series were identified by searching the Medline database using the key words antiphospholipid syndrome, anticoagulants and names of the NOACs, and data on individual patients was abstracted...
June 2017: Clinical Medicine & Research
https://www.readbyqxmd.com/read/28750060/correction-the-new-face-of-the-old-molecules-crustin-pm4-and-transglutaminase-type-i-serving-as-rnps-down-regulate-astakine-mediated-hematopoiesis
#16
Yun-Tsan Chang, Cheng-Yung Lin, Che-Yiang Tsai, Vinu S Siva, Chia-Ying Chu, Huai-Jen Tsai, Yen-Ling Song
[This corrects the article DOI: 10.1371/journal.pone.0072793.].
2017: PloS One
https://www.readbyqxmd.com/read/28749553/myelopathy-in-beh%C3%A3-et-s-disease-the-bagel-sign
#17
Ugur Uygunoglu, Burcu Zeydan, Yesim Ozguler, Serdal Ugurlu, Emire Seyahi, Naci Kocer, Civan Islak, Kejal Kantarci, Sabahattin Saip, Aksel Siva, Orhun H Kantarci
OBJECTIVE: To describe the clinical and distinctive imaging features of myelopathy associated with Behçet's disease (BD). METHODS: We evaluated the records of patients meeting the following criteria: (1) fulfillment of the International Study Group criteria for BD; (2) clinically suggestive of myelopathy; (3) simultaneous spinal cord and brain magnetic resonance images (MRIs) within 1 month of acute worsening of myelopathy; and (4) follow-up duration ≥ 1 year after initial MRI evaluation...
July 27, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28746943/identification-of-3-novel-patients-with-clcn2-related-leukoencephalopathy-due-to-clcn2-mutations
#18
Burcu Zeydan, Ugur Uygunoglu, Ayse Altintas, Sabahattin Saip, Aksel Siva, Truus E M Abbink, Marjo S van der Knaap, Cengiz Yalcinkaya
No abstract text is available yet for this article.
July 26, 2017: European Neurology
https://www.readbyqxmd.com/read/28741962/primary-pituitary-tubercular-abscess-as-a-differential-diagnosis-for-sellar-suprasellar-mass
#19
Venkataramana Pamidimukkala, Deepak Sahebrao Mandwe, Siva Ramakrishna K, Harshavardhan Batsala
Only four cases of primary pituitary tubercular abscess have been reported. A 20-year-old ladypresented to us with headache and pituitary dysfunction. Radiology showedsellar tubercular abscess with suprasellar extension. Microscopic examination of pus collected during surgery showed granulomatous tissues and Acid Fast Bacilli. The response to antitubercular therapy was remarkable.
July 25, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28740171/a-modified-formulation-of-huanglian-jie-du-tang-reduces-memory-impairments-and-%C3%AE-amyloid-plaques-in-a-triple-transgenic-mouse-model-of-alzheimer-s-disease
#20
Siva Sundara Kumar Durairajan, Ashok Iyaswamy, Sravan Gopalakrishna Shetty, Ananth Kumar Kammella, Sandeep Malampati, Wenbin Shang, Chuanbin Yang, Juxian Song, Sookja Chung, Jiandong Huang, Kaliappan Ilango, Quan-Bin Han, Min Li
Alzheimer's disease (AD) is a degenerative disorder typified by progressive deterioration of memory and the appearance of β-amyloid peptide (Aβ)-rich senile plaques. Recently we have identified a novel function of a patented formulation of modified Huanglian-Jie-Tu-Tang (HLJDT-M), a Chinese herbal medicine, in treating AD in in vitro studies (US patent No. 9,375,457). HLJDT-M is a formulation composed of Rhizoma Coptitis, Cortex Phellodendri and Fructus Gardeniae without Radix Scutellariae. Here, we assessed the efficacy of HLJDT-M on a triple transgenic mouse model of AD (3XTg-AD)...
July 24, 2017: Scientific Reports
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