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Siva Ganesh, Vanessa Cave
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December 11, 2017: New Zealand Veterinary Journal
S Gandhidasan, D Ball, T Kron, M Bressel, M Shaw, J Chu, S Chander, G Wheeler, N Plumridge, B Chesson, S David, S Siva
AIMS: Stereotactic ablative body radiotherapy (SABR) is currently used to treat oligometastases, but the optimum dose/fractionation schedule is unknown. In this study, we evaluated outcomes after single fraction SABR in patients with oligometastatic disease. MATERIALS AND METHODS: Single institutional retrospective review of patients treated with single fraction SABR for one to three oligometastases between 2010 and 2015. The primary outcome was freedom from widespread disease defined as distant recurrence not amenable to surgery or SABR; or recurrence with four or more metastases...
December 7, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
Heather Torbic, Hanine Inaty, Siva Raja, Humberto Choi
Instillation of intrapleural (IP) fibrinolytics has been used in patients with complicated parapneumonic pleural effusions to improve fluid drainage and decrease the need for surgical intervention. However, clinical trials have not included certain special populations such as pregnant females and there are currently no published case reports of this practice in this group. We describe the case of a 35-year-old female, G2P1 at 32 weeks of gestation, with a complicated pleural effusion due to influenza pneumonia with superimposed bacterial pneumonia...
September 2017: Journal of Thoracic Disease
Venkata Siva Gummaluri, Radhika V Nair, S R Krishnan, C Vijayan
In this Letter, we report on the design, fabrication, and implementation of a novel plasmon-mode-driven low-threshold near-infrared (NIR) random laser (RL) in the 850-900 nm range based on plasmonic ZnS@Au core-shell scatterers. Plasmon modes in the NIR region are used for nanoscale scatterer engineering of ZnS@Au core-shell particles to enhance scattering, as against pristine ZnS. This plasmonic scattering enhancement coupled with femtosecond (fs) laser pumping is shown to cause a three-fold lasing threshold reduction from 325  μJ/cm2 to 100  μJ/cm2 and a mode Q-factor enhancement from 200 to 540 for ZnS@Au-based RL, as compared to pristine ZnS-based RL...
December 1, 2017: Optics Letters
Jennifer Leigh Rodgers, Eva Samal, Subhra Mohapatra, Siva Kumar Panguluri
Hyperoxia, or supplemental oxygen, is regularly used in the clinical setting for critically ill patients in ICU. However, several recent studies have demonstrated the negative impact of this treatment in patients in critical care, including increased rates of lung and cardiac injury, as well as increased mortality. The purpose of this study was to determine the predisposition for arrhythmias and electrical remodeling in a type 2 diabetic mouse model (db/db), as a result of hyperoxia treatment. For this, db/db and their heterozygous controls were treated with hyperoxia (> 90% oxygen) or normoxia (normal air) for 72-h...
December 5, 2017: Heart and Vessels
Rafael Casas, Siva Muthusamy, Paul G Wakim, Sanhita Sinharay, Margaret R Lentz, William C Reid, Dima A Hammoud
Introduction: HIV infection is known to be associated with brain volume loss, even in optimally treated patients. In this study, we assessed whether dynamic brain volume changes over time are predictive of neurobehavorial performance in the HIV-1 transgenic (Tg) rat, a model of treated HIV-positive patients. Materials and methods: Cross-sectional brain MRI imaging was first performed comparing Tg and wild type (WT) rats at 3 and 19 months of age. Longitudinal MRI and neurobehavioral testing of another group of Tg and WT rats was then performed from 5 to 23 weeks of age...
2018: NeuroImage: Clinical
Alexandra B Keenan, Sherry L Jenkins, Kathleen M Jagodnik, Simon Koplev, Edward He, Denis Torre, Zichen Wang, Anders B Dohlman, Moshe C Silverstein, Alexander Lachmann, Maxim V Kuleshov, Avi Ma'ayan, Vasileios Stathias, Raymond Terryn, Daniel Cooper, Michele Forlin, Amar Koleti, Dusica Vidovic, Caty Chung, Stephan C Schürer, Jouzas Vasiliauskas, Marcin Pilarczyk, Behrouz Shamsaei, Mehdi Fazel, Yan Ren, Wen Niu, Nicholas A Clark, Shana White, Naim Mahi, Lixia Zhang, Michal Kouril, John F Reichard, Siva Sivaganesan, Mario Medvedovic, Jaroslaw Meller, Rick J Koch, Marc R Birtwistle, Ravi Iyengar, Eric A Sobie, Evren U Azeloglu, Julia Kaye, Jeannette Osterloh, Kelly Haston, Jaslin Kalra, Steve Finkbiener, Jonathan Li, Pamela Milani, Miriam Adam, Renan Escalante-Chong, Karen Sachs, Alex Lenail, Divya Ramamoorthy, Ernest Fraenkel, Gavin Daigle, Uzma Hussain, Alyssa Coye, Jeffrey Rothstein, Dhruv Sareen, Loren Ornelas, Maria Banuelos, Berhan Mandefro, Ritchie Ho, Clive N Svendsen, Ryan G Lim, Jennifer Stocksdale, Malcolm S Casale, Terri G Thompson, Jie Wu, Leslie M Thompson, Victoria Dardov, Vidya Venkatraman, Andrea Matlock, Jennifer E Van Eyk, Jacob D Jaffe, Malvina Papanastasiou, Aravind Subramanian, Todd R Golub, Sean D Erickson, Mohammad Fallahi-Sichani, Marc Hafner, Nathanael S Gray, Jia-Ren Lin, Caitlin E Mills, Jeremy L Muhlich, Mario Niepel, Caroline E Shamu, Elizabeth H Williams, David Wrobel, Peter K Sorger, Laura M Heiser, Joe W Gray, James E Korkola, Gordon B Mills, Mark LaBarge, Heidi S Feiler, Mark A Dane, Elmar Bucher, Michel Nederlof, Damir Sudar, Sean Gross, David F Kilburn, Rebecca Smith, Kaylyn Devlin, Ron Margolis, Leslie Derr, Albert Lee, Ajay Pillai
The Library of Integrated Network-Based Cellular Signatures (LINCS) is an NIH Common Fund program that catalogs how human cells globally respond to chemical, genetic, and disease perturbations. Resources generated by LINCS include experimental and computational methods, visualization tools, molecular and imaging data, and signatures. By assembling an integrated picture of the range of responses of human cells exposed to many perturbations, the LINCS program aims to better understand human disease and to advance the development of new therapies...
November 24, 2017: Cell Systems
Keita Matsumoto, Robert J Knell
When male animals engage in intrasexual contests then any alternative tactics they use can be associated with dimorphisms in the expression of weapons. Some species have recently been found to exhibit trimorphism in their weaponry, suggesting that the processes leading to their evolution and maintenance of these polymorphisms can be more complex than previously thought. Here, we describe the extraordinary diversity of polymorphism within the genus Odontolabis: there are dimorphic species (O. siva and O. platynota), trimorphic species (O...
December 1, 2017: Scientific Reports
Hyo Sang Jang, Martin Pearce, Edmond F O'Donnell, Bach Duc Nguyen, Lisa Truong, Monica J Mueller, William H Bisson, Nancy I Kerkvliet, Robert L Tanguay, Siva Kumar Kolluri
We previously reported that raloxifene, an estrogen receptor modulator, is also a ligand for the aryl hydrocarbon receptor (AhR). Raloxifene induces apoptosis in estrogen receptor-negative human cancer cells through the AhR. We performed structure-activity studies with seven raloxifene analogs to better understand the structural requirements of raloxifene for induction of AhR-mediated transcriptional activity and apoptosis. We identified Y134 as a raloxifene analog that activates AhR-mediated transcriptional activity and induces apoptosis in MDA-MB-231 human triple negative breast cancer cells...
December 1, 2017: Biology
Thomas Lee Torp, Ryo Kawasaki, Tien Yin Wong, Tunde Peto, Jakob Grauslund
PURPOSE: We aimed to investigate changes in retinal vascular geometry over time after panretinal photocoagulation (PRP) in patients with proliferative diabetic retinopathy (PDR). METHODS: Thirty-seven eyes with PDR were included. Wide-field fluorescein angiography (Optomap, Optos PLC., Dunfermline, Scotland, UK) was used to diagnose PDR at baseline and to assess activity at follow-up month three and six. At each time-point, a trained grader measured retinal vessel geometry on optic disc (OD) centred images using semiautomated software (SIVA, Singapore I Vessel Assessment, National University of Singapore, Singapore) according to a standardized protocol...
November 29, 2017: Acta Ophthalmologica
Joshua Butson, Parvathala Reddy Narangari, Siva Krishna Karuturi, Rowena Yew, Mykhaylo Lysevych, Hoe Tan, Chennupati Jagadish
The research interest in photoelectrochemical (PEC) water splitting is ever growing due to its potential to contribute towards clean and portable energy. However, the lack of low energy band gap materials with high photocorrosion resistance is the primary setback inhibiting this technology from commercialisation. The ternary alloy InGaN shows promise to meet the photoelectrode material requirements due to its high chemical stability and band gap tunability. The band gap of InGaN can be modulated from the UV to IR regions by adjusting the In concentration so as to absorb the maximum portion of the solar spectrum...
December 1, 2017: Nanotechnology
Cristian Udovicich, Marlon Perera, Michael S Hofman, Shankar Siva, Andres Del Rio, Declan G Murphy, Nathan Lawrentschuk
The early and accurate detection of prostate cancer is important to ensure timely management and appropriate individualized treatment. Currently, conventional imaging has limitations particularly in the early detection of metastases and at prostate-specific antigen (PSA) levels < 2.0 ng/mL. Furthermore, disease management such as salvage radiotherapy is best at low PSA levels. Thus, it is critical to capture the disease in the oligometastatic stage as disease progression and commencement of systemic therapies can be delayed by metastasis-directed therapy...
December 2017: Prostate International
Abdul Habeeb Bin Mohsin, Varalakshmi Reddy, Praveen Kumar, Jeevan Raj, Siva Santosh Babu
Introduction: The aim of this study was to evaluate & compare the wetting ability of five saliva substitutes & distilled water on heat-polymerized acrylic resin. Contact angle of the saliva substitute on denture base can be taken as an indicator of wettability. Good wetting of heat-polymerized acrylic resin is critical for optimum retention of complete dentures. Methods: Two hundred & forty samples of heat-polymerized acrylic resin were fabricated using conventional method...
2017: Pan African Medical Journal
Qi-Fang Huang, Fang-Fei Wei, Zhen-Yu Zhang, Anke Raaijmakers, Kei Asayama, Lutgarde Thijs, Wen-Yi Yang, Blerim Mujaj, Karel Allegaert, Peter Verhamme, Harry A J Struijker-Boudier, Yan Li, Jan A Staessen
BACKGROUND: Retinal microvascular traits predict adverse health outcomes. The Singapore I Vessel Assessment (SIVA) software improved automated post-processing of retinal photographs. In addition to microvessel caliber, it generates measures of arteriolar and venular geometry. Few studies addressed the reproducibility of SIVA measurements across a wide age range. METHODS: In the current study, two blinded graders read images obtained by nonmydriatic retinal photography twice in twenty 11-year old children, born prematurely (n = 10) or at term (n = 10) and in sixty adults (age range, 18...
November 24, 2017: American Journal of Hypertension
Jayaprakash Shenthar, Jayasheelan Mambally Rachaiah, Vivek Pillai, Siva Sankara Chakali, Vidhyakar Balasubramanian, Manjunath Chollenhalli Nanjappa
AIM: To define the incidence, presentation, and outcomes of drug-induced Torsades de Pointes (TdP) with intravenous (IV) amiodarone. METHODS: From January 2014 to August 2016 a total of 268 patients received IV amiodarone, 142 for ventricular tachycardia, 104 for atrial flutter/fibrillation, and 22 for incessant atrial tachycardia. A uniform dosing of amiodarone to yield 1gm/day was used in all patients. RESULTS: Four of the 268 patients (M:F 1:3) with mean age of 51...
November 2017: Indian Heart Journal
Kazi T Islam, Siva L S Velivelli, R Howard Berg, Blake Oakley, Dilip M Shah
Defensins are cysteine-rich cationic antimicrobial peptides contributing to the innate immunity in plants. A unique gene encoding a highly cationic bi-domain defensin MtDef5 has been identified in a model legume Medicago truncatula. MtDef5 consists of two defensin domains of 50 amino acids each linked by a 7-amino acid peptide. It exhibits broad-spectrum antifungal activity against filamentous fungi at submicromolar concentrations. It rapidly permeabilizes the plasma membrane of the ascomycete fungi Fusarium graminearum and Neurospora crassa and induces accumulation of reactive oxygen species...
November 23, 2017: Scientific Reports
Jianqin Lei, Mayss Al-Sheikh, Yue Shi, Akihito Uji, Wenying Fan, Siva Balasubramanian, SriniVas R Sadda
PURPOSE: To assess the reproducibility of confocal white-light color fundus photography (C-CFP) for the measurement of retinal pigment epithelial atrophy in comparison with confocal blue-light fundus autofluorescence (FAF) imaging and flash color fundus photography (F-CFP). METHODS: In this prospective study, eyes with age-related macular degeneration associated with evidence of retinal pigment epithelial atrophy were imaged by C-CFP, F-CFP, and FAF. Intergrader reproducibility of each modality was assessed by comparison of manual measurements by two expert graders...
November 16, 2017: Retina
K N Soujanya, R Siva, P Mohana Kumara, Amitava Srimany, G Ravikanth, F A Mulani, T Aarthy, H V Thulasiram, T R Santhoshkumar, Karaba N Nataraja, R Uma Shaanker
BACKGROUND: Camptothecin (CPT), a quinoline alkaloid, is a potent inhibitor of eukaryotic topoisomerase I. Because of this property, several derivatives of CPT are used as chemotherapeutic agents. CPT is produced by several plant species belonging to the Asterid clade as well as by a number of endophytic fungal associates of these plants. In this study, we report the production of CPT by four bacterial endophytes and show the possible role of a plasmid in the biosynthesis of CPT. METHODS: Endophytic bacteria were isolated from leaves, stems and fruits of Pyrenacantha volubilis Hook...
December 1, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Aksel Siva
Multiple Sclerosis is increasing, so is the number of misdiagnosed cases as MS. One major source of misdiagnosis is misinterpretation of nonspecific clinical and imaging findings and misapplication of MS diagnostic criteria resulting in an overdiagnosis of MS! Since nonspecific white matter abnormalities on brain MRI and other imaging findings that may mimic MS, as well as MS-nonspecific lesions that are seen in people with MS, neurologists should be aware of all possibilities and should be able to interpret the clinical and MRI findings well and by their selves! The differential diagnosis of MS includes MS variants and inflammatory astrocytopathies and other atypical inflammatory-demyelinating syndromes, as well as a number of systemic diseases with CNS involvement...
February 2018: Neurologic Clinics
Christine Lebrun, Orhun H Kantarci, Aksel Siva, Daniel Pelletier, Darin T Okuda
Radiologically isolated syndrome (RIS) was defined in 2009 for asymptomatic patients who presented incidentally identified white matter anomalies within the central nervous system suggestive of multiple sclerosis (MS). Approximately one-third of RIS subjects will have a seminal clinical demyelinating event within 5 years of the identification of their abnormal MRI. Clinical evolution mirrors relapsing remitting or progressive forms of MS. Pejorative factors for clinical conversion are male gender, age younger than 35 years, and spinal cord lesions...
February 2018: Neurologic Clinics
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