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https://www.readbyqxmd.com/read/27909537/a-comparison-between-noacs-and-warfarin-on-time-to-elective-cardioversion
#1
REVIEW
Siva Krothapalli Md, Prashant D Bhave Md Fhrs
Cardioversion of atrial fibrillation is a procedure that has been commonly performed for over half a century. There is known to be an elevated risk of thromboembolism around the time of cardioversion, which has been shown to be drastically reduced with oral anticoagulation. The consistency of therapeutic anticoagulation in the weeks leading up to elective cardioversion is an important factor in the safety of the procedure. Until recently, the only option for oral anti-coagulation was Warfarin. The challenges of dosing Warfarin to achieve a therapeutic INR are well documented...
August 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27909501/-two-for-the-price-of-one-a-single-lead-implantable-cardioverter-defibrillator-system-with-a-floating-atrial-dipole
#2
REVIEW
Nicole E Worden Md, Musab Alqasrawi Md, Siva M Krothapalli Md, Alexander Mazur Md
In patients known to be a high risk for sudden cardiac arrest, implantable cardioverter defibrillators (ICD) are a proven therapy to reduce risk of death. However, in patients without conventional indications for pacing, the optimal strategy for type of device, dual- versus single-chamber, remains debatable. The benefit of prophylactic pacing in this category of patients has never been documented. Although available atrial electrograms in a dual chamber system improve interpretation of stored arrhythmia events, allow monitoring of atrial fibrillation and may potentially reduce the risk of inappropriate shocks by enhancing automated arrhythmia discrimination, the use of dual-chamber ICDs has a number of disadvantages...
April 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27908259/a-novel-liquid-chromatography-tandem-mass-spectrometry-method-for-the-estimation-of-bilirubin-glucuronides-and-its-application-to-in-vitro-enzyme-assays
#3
Siva Prasad Putluru, Murali Krishna Matta, Deepak Ahire, Murali Subramanian, Michael Sinz, Sandhya Mandlekar
Bilirubin is a toxic waste product of metabolism, eliminated mainly through UGT1A1 mediated conjugation to mono- and di-glucuronides. Due to the potentially low Km value of bilirubin glucuronidation, the quantitative sensitivity obtained with most UV/visible light detection methods are not sufficient to accurately calculate UGT1A1 enzyme kinetics and inhibition properties of new chemical entities at low bilirubin concentrations. In addition, bilirubin, as well as its metabolites, are unstable during sample preparation and bioanalysis...
November 24, 2016: Drug Metabolism Letters
https://www.readbyqxmd.com/read/27891370/trace-elements-in-chronic-haemodialysis-patients-and-healthy-individuals-a-comparative-study
#4
Lokesh Shanmugam, Siva Ranganathan Green, Hemachandar Radhakrishnan, Tony Mathew Kadavanu, Arunkumar Ramachandrappa, Shashank Rakesh Tiwari, Amirtha Lakshmi Rajkumar, Ezhumalai Govindasamy
INTRODUCTION: End Stage Renal Disease (ESRD) patients despite receiving adequate Haemodialysis (HD) develop significant risk of Cardiovascular Disease (CVD). Abnormality in levels of trace elements may potentiate vascular injury by producing sustained inflammation and endothelial dysfunction. Hence, the present study was undertaken to evaluate the levels of trace elements in patients receiving HD. AIM: To study the blood levels of arsenic, cadmium, mercury, lead, chromium, barium, cobalt, caesium and selenium among ESRD patients undergoing HD and compare it with healthy individuals...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27890700/biochanin-a-attenuates-neuropathic-pain-in-diabetic-rats
#5
Venkateswarlu Chundi, Siva Reddy Challa, Devala Rao Garikapati, Giridhar Juvva, Anusha Jampani, Sree Harsha Pinnamaneni, Sahithi Venigalla
BACKGROUND: Soya supplements are used in the treatment of neuropathic pain. Previous reports reveal that consumption of soy diet before nerve injury prevents the development of neuropathic pain in rats. Biochanin-A, a soy isoflavone, has a naturally occurring inhibitor of fatty acid amide hydrolase (FAAH) that metabolized endocannabinoids. OBJECTIVE: The objective was to evaluate efficacy of biochanin-A in streptozotocin (STZ) induced neuropathic pain in rat model...
November 25, 2016: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/27881915/copd-care-delivery-pathways-in-five-european-union-countries-mapping-and-health-care-professionals-perceptions
#6
Reem Kayyali, Bassel Odeh, Inéz Frerichs, Nikki Davies, Eleni Perantoni, Shona D'arcy, Anouk W Vaes, John Chang, Martijn A Spruit, Brenda Deering, Nada Philip, Roshan Siva, Evangelos Kaimakamis, Ioanna Chouvarda, Barbara Pierscionek, Norbert Weiler, Emiel Fm Wouters, Andreas Raptopoulos, Shereen Nabhani-Gebara
BACKGROUND: COPD is among the leading causes of chronic morbidity and mortality in the European Union with an estimated annual economic burden of €25.1 billion. Various care pathways for COPD exist across Europe leading to different responses to similar problems. Determining these differences and the similarities may improve health and the functioning of health services. OBJECTIVE: The aim of this study was to compare COPD patients' care pathway in five European Union countries including England, Ireland, the Netherlands, Greece, and Germany and to explore health care professionals' (HCPs) perceptions about the current pathways...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27881435/healthcare-comes-to-standstill-in-east-aleppo-as-last-hospitals-are-destroyed
#7
Nayanah Siva
No abstract text is available yet for this article.
November 23, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27864849/impact-of-plant-growth-promoting-rhizobacteria-on-root-colonization-potential-and-life-cycle-of-rhizophagus-irregularis-following-co-entrapment-into-alginate-beads
#8
Paul Loján, Marion Demortier, Siva L S Velivelli, Stefan Pfeiffer, Juan Pablo Suárez, Paul de Vos, Barbara Doyle Prestwich, Angela Sessitsch, Stéphane Declerck
AIMS: This study aimed at evaluating the impact of seven plant growth-promoting rhizobacteria (PGPR) on root colonization and life cycle of Rhizophagus irregularis MUCL 41833 when co-entrapped in alginate beads. METHODS AND RESULTS: Two in vitro experiments were conducted. The first consisted in the immobilization of R. irregularis and seven PGPR isolates into alginate beads to assess the effect of the bacteria on the pre-symbiotic growth of the fungus. In the second experiment, the best-performing PGPR from experiment 1 was tested on its ability to promote the symbiotic development of the AMF in potato plantlets from three cultivars...
November 19, 2016: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/27864741/an-ultrasensitive-label-free-nanobiosensor-platform-for-the-detection-of-cardiac-biomarkers
#9
Durga Prakash Matta, Suryasnata Tripathy, Siva Rama Krishna Vanjari, Chandra Shekhar Sharma, Shiv Govind Singh
We report the fabrication of a label free nano biosensor platform comprising single nanofiber that is derived out of multi-walled carbon nanotubes (MWCNTs) embedded SU-8 photoresist, for the detection of three important human cardiac biomarkers viz., myoglobin (Myo), cardiac Troponin I (cTn I) and Creatine Kinase-MB (CK-MB). These composite nanofibers were synthesized using electrospinning process. Single nanofibers were aligned between pairs of electrodes in-situ during the electrospinning process. The target proteins were detected using chemiresistive detection methodology...
December 2016: Biomedical Microdevices
https://www.readbyqxmd.com/read/27856219/cuticular-colour-reflects-underlying-architecture-and-is-affected-by-a-limiting-resource
#10
Sophie E F Evison, Joe D Gallagher, John J W Thompson, Michael T Siva-Jothy, Sophie A O Armitage
Central to the basis of ecological immunology are the ideas of costs and trade-offs between immunity and life history traits. As a physical barrier, the insect cuticle provides a key resistance trait, and Tenebrio molitor shows phenotypic variation in cuticular colour that correlates with resistance to the entomopathogenic fungus Metarhizium anisopliae. Here we first examined whether there is a relationship between cuticular colour variation and two aspects of cuticular architecture that we hypothesised may influence resistance to fungal invasion through the cuticle: its thickness and its porosity...
November 14, 2016: Journal of Insect Physiology
https://www.readbyqxmd.com/read/27843853/satisfaction-of-antenatal-mothers-with-the-care-provided-by-nurse-midwives-in-an-urban-secondary-care-unit
#11
Ruby Angeline Pricilla, Kirubah Vasandhi David, Rajeswari Siva, T Jeni Christal Vimala, Sajitha Parveen M F Rahman, Venkatesan Sankarapandian
BACKGROUND: The satisfaction of antenatal women to antenatal services has rarely been studied in India. In a nation with a maternal mortality ratio of 178/100,000 live births, it is crucial to explore all avenues to reduce it. AIMS: Our study aims to assess the pregnant women's satisfaction with regard to antenatal care services provided by nurse-midwives in an urban health center in South India. METHODS: We administered a satisfaction of care questionnaire to 200 consecutive antenatal women attending the nurse run antenatal clinics from April 2014 to November 2014...
April 2016: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/27843216/the-peritoneal-scaffold-technique-of-extended-pelvic-lymph-node-dissection-during-radical-prostatectomy-a-novel-technique
#12
Chiruvella Mallikarjuna, Prasant Nayak, Syed Mohammed Ghouse, K Purnachandra Reddy, Deepak Reddy Ragoori, M T Bendigeri, Siva Reddy
INTRODUCTION: Laparoscopic or robotic-assisted laparoscopic radical prostatectomy (RALP) is a frequently used approach for localized carcinoma prostate. For intermediate and high-risk cancers, extended pelvic lymph node dissection (e-PLND), is often performed. Conventional e-PLND involves piecemeal retrieval of lymphatic tissue. We describe a novel technique of laparoscopic e-PLND, which involves en-masse removal of pelvic lymph nodes from each side, based on an overlying peritoneal scaffold...
October 2016: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/27828146/portable-optofluidic-absorption-flow-analyzer-for-quantitative-malaria-diagnosis-from-whole-blood
#13
Earu Banoth, Vamshi Krishna Kasula, Sai Siva Gorthi
Fast and automated diagnostic devices are bound to play a significant role in the on-going efforts toward malaria eradication. In this article, we present the realization of a portable device for quantitative malaria diagnostic testing at the point-of-care. The device measures optical absorbance (at λ=405  nm) of single cells flowing through a custom-designed microfluidic channel. The device incorporates the required functionality to align the microfluidic channel with the optical interrogation region...
October 20, 2016: Applied Optics
https://www.readbyqxmd.com/read/27818793/transient-decrease-in-circulatory-testosterone-and-homocysteine-precedes-the-development-of-metabolic-syndrome-features-in-fructose-fed-sprague-dawley-rats
#14
Anil Sakamuri, Sujatha Pitla, Uday Kumar Putcha, Sugeedha Jayapal, Sailaja Pothana, Sai Santosh Vadakattu, Nagabhushan Reddy Konapalli, Siva Sankara Vara Prasad Sakamuri, Ahamed Ibrahim
Background. Increased fructose consumption is linked to the development of metabolic syndrome (MS). Here we investigated the time course of development of MS features in high-fructose-fed Sprague Dawley rats along with circulatory testosterone and homocysteine levels. Methods. Rats were divided into control and experimental groups and fed with diets containing 54.5% starch and fructose, respectively, for 4, 12, and 24 weeks. Plasma testosterone and homocysteine levels were measured along with insulin, glucose, and lipids...
2016: Journal of Nutrition and Metabolism
https://www.readbyqxmd.com/read/27809945/effect-of-whey-protein-and-a-free-amino-acid-mixture-simulating-whey-protein-on-measures-of-satiety-in-normal-weight-women
#15
Sylvia M S Chungchunlam, Sharon J Henare, Siva Ganesh, Paul J Moughan
Dietary protein is considered more satiating than carbohydrate, and whey protein is more satiating than other protein sources. The purported satiating effect of whey protein may be due to direct effects of the unique mixture of proteins in whey, due to the effects of peptides released upon digestion and/or its amino acid composition. The objective of the present study was to compare the satiating effects of intact whey protein isolate (WPI) or a free amino acid mixture (AAM) simulating the amino acid composition of the WPI...
November 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/27797971/an-open-label-dose-escalation-phase-i-study-of-anti-tyrp1-monoclonal-antibody-imc-20d7s-for-patients-with-relapsed-or-refractory-melanoma
#16
Danny N Khalil, Michael A Postow, Nageatte Ibrahim, Dale L Ludwig, Jan Cosaert, Siva Rama Prasad Kambhampati, Shande Tang, Dmitri Grebennik, John Sae Wook Kauh, Heinz-Josef Lenz, Keith T Flaherty, F Stephen Hodi, Donald P Lawrence, Jedd D Wolchok
PURPOSE: Tyrosinase-related protein-1 (TYRP1) is a transmembrane glycoprotein that is specifically expressed in melanocytes and melanoma cells. Preclinical data suggest that mAbs targeting TYRP1 confer antimelanoma activity. IMC-20D7S is a recombinant human IgG1 mAb targeting TYRP1. Here, we report the first-in-human phase I/Ib trial of IMC-20D7S. EXPERIMENTAL DESIGN: The primary objective of this study was to establish the safety profile and the MTD of IMC-20D7S...
November 1, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27797871/procedural-sedation-in-the-emergency-department-by-dutch-emergency-physicians-a-prospective-multicentre-observational-study-of-1711-adults
#17
Gaël Jp Smits, Maybritt I Kuypers, Lisette Aa Mignot, Eef Pj Reijners, Erick Oskam, Karen Van Doorn, Wendy Amh Thijssen, Erik Hm Korsten
OBJECTIVE: To describe our experience performing ED procedural sedation in a country where emergency medicine (EM) is a relatively new specialty. METHODS: This is a prospective observational study of adult patients undergoing procedural sedation by emergency physicians (EPs) or EM residents in eight hospitals in the Netherlands. Data were collected on a standardised form, including patient characteristics, sedative and analgesic used, procedural success, adverse events (classified according to World SIVA) and rescue interventions...
October 21, 2016: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/27795652/-antihemophilic-factor-is-not-the-only-answer-for-all-factor-viii-deficiencies-case-report-of-odontogenic-infection-in-a-patient-with-hemophilia-a-complicated-by-factor-viii-inhibitors-and-managed-by-transfusion-of-antihemophilic-factor-and-factor-viii-inhibitor
#18
K M Sudheesh, K S N Siva Bharani, H Y Kiran, Suresh Hanagavadi
Dental extraction in hemophiliacs with acquired inhibitors is always a risky procedure, which often presents a lot of problems associated with bleeding. A known case of hemophilia A complicated with factor VIII inhibitors and having odontogenic infection was successfully managed by transfusion of factor VIII inhibitor bypass activity (FEIBA) and antihemophilic factor. Past medical history was significant for multiple factor VIII transfusions. Bethesda assay done to identify inhibitors revealed low titer factor VIII inhibitors...
September 2016: Indian Journal of Dentistry
https://www.readbyqxmd.com/read/27793271/non-imaging-assisted-insertion-of-un-cuffed-non-tunneled-internal-jugular-venous-catheters-for-hemodialysis-safety-and-utility-in-modern-day-world
#19
COMMENT
Manish Rathi, Venkata Siva Tez Pinnamaneni, Vinay Sakhuja
BACKGROUND: Absolute necessity in acute kidney injury (AKI) and ignorance in chronic kidney disease (CKD) make the use of un-cuffed, non-tunneled catheters an indispensable vascular access for hemodialysis. Although these catheters should be inserted under radiological guidance, it may not be feasible in certain circumstances. The aim of the present study was to evaluate safety and outcome of non-imaging assisted insertion of these catheters in internal jugular vein (IJV) for hemodialysis...
August 2016: Biomedical Journal
https://www.readbyqxmd.com/read/27790486/a-comparative-study-of-lipid-profile-and-cardiovascular-risk-biomarkers-among-chronic-haemodialysis-patients-and-healthy-individuals
#20
Shanmugam Lokesh, Tony Mathew Kadavanu, Siva Ranganathan Green, Tarun Kumar Dutta, Radhakrishnan Hemachandar, Arun Kumar Ramachandrappa, Shashank Rakesh Tiwari, Ezhumalai Govindasamy
INTRODUCTION: Lipid abnormalities and increase in inflammatory markers are common among patients with End Stage Renal Disease (ESRD) and it tends to persist/worsen even after initiating Intermittent Haemodialysis (IHD). The cardiovascular mortality and morbidity remains significantly high in this population. AIM: The present study was carried out to assess the pattern of lipid abnormality in our population and to find its association with inflammatory markers. MATERIALS AND METHODS: It was a cross-sectional, observational study on ESRD patients undergoing Haemodialysis (HD) in comparison with age and sex matched healthy individuals in a tertiary care hospital...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
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