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Peripheral arterial calcification

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https://www.readbyqxmd.com/read/27905995/cdkn2b-methylation-is-associated-with-carotid-artery-calcification-in-ischemic-stroke-patients
#1
Shuyu Zhou, Yumeng Zhang, Li Wang, Zhizhong Zhang, Biyang Cai, Keting Liu, Hao Zhang, Minhui Dai, Lingli Sun, Xiaomeng Xu, Huan Cai, Xinfeng Liu, Guangming Lu, Gelin Xu
BACKGROUND: Cyclin-dependent kinase inhibitor 2A/2B (CDKN2A/2B) near chromosome 9p21 have been associated with both atherosclerosis and artery calcification, but the underlying mechanisms remained largely unknown. Considering that CDKN2A/2B is a frequently reported site for DNA methylation, this study aimed to evaluate whether carotid artery calcification (CarAC) is related to methylation levels of CDKN2A/2B in patients with ischemic stroke. METHODS: DNA methylation levels of CDKN2A/2B were measured in 322 ischemic stroke patients using peripheral blood leukocytes...
December 1, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27899247/association-of-plasma-fetuin-a-levels-with-peripheral-arterial-disease-and-lower-extremity-arterial-calcification-in-subjects-with-type-2-diabetes-mellitus
#2
Ioanna Eleftheriadou, Pinelopi Grigoropoulou, Alexander Kokkinos, Iordanis Mourouzis, Despoina Perrea, Nicholas Katsilambros, Petros P Sfikakis, Nikolaos Tentolouris
AIMS: Fetuin-A is a hepatic glycoprotein that is involved in insulin resistance and atherosclerosis. Herein we examined the association of plasma fetuin-A levels with peripheral arterial disease (PAD) in patients with type 2 diabetes mellitus (T2DM). MATERIAL AND METHODS: A total of 71 patients with T2DM and 57 non-diabetic individuals were recruited. Diagnosis of PAD was based on the absence of triphasic waveform at pedal arteries, while ankle-brachial index (ABI) was calculated...
November 12, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27898199/microsurgical-reconstruction-in-patients-greater-than-80-years-old
#3
Paul I Heidekrueger, Albrecht Heine-Geldern, Milomir Ninkovic, Frank Herter, Daniel Schmauss, Thiha Aung, P Niclas Broer
BACKGROUND: Demographic change implies that the human population is getting older and the elderly are living longer. Consequently, achieving good functional and aesthetic outcomes in microvascular procedures, especially in very old patients with higher incidence of atherosclerosis and vessel calcifications, constitutes a microsurgical challenge. This study evaluates the feasibility of microsurgical procedures in a very old patient cohort. PATIENTS AND METHODS: Between 2009 and 2015, 754 patients underwent 838 free flap reconstructions...
November 29, 2016: Microsurgery
https://www.readbyqxmd.com/read/27890524/the-dancavas-pilot-study-of-multifaceted-screening-for-subclinical-cardiovascular-disease-in-men-and-women-aged-65-74%C3%A2-years
#4
T V Kvist, J S Lindholt, L M Rasmussen, R Søgaard, J Lambrechtsen, F H Steffensen, L Frost, M H Olsen, H Mickley, J Hallas, G Urbonaviciene, M Busk, K Egstrup, A C P Diederichsen
OBJECTIVE/BACKGROUND: This pilot study of a large population based randomised screening trial investigated feasibility, acceptability, and relevance (prevalence of clinical and subclinical cardiovascular disease [CVD] and proportion receiving insufficient prevention) of a multifaceted screening for CVD. METHODS: In total, 2060 randomly selected Danish men and women aged 65-74 years were offered (i) low dose non-contrast computed tomography to detect coronary artery calcification (CAC) and aortic/iliac aneurysms; (ii) detection of atrial fibrillation (AF); (iii) brachial and ankle blood pressure measurements; and (iv) blood levels of cholesterol and hemoglobin A1c...
November 24, 2016: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/27865565/-ankle-brachial-index-screening-for-peripheral-artery-disease-in-high-cardiovascular-risk-patients-prospective-observational-study-of-370-asymptomatic-patients-at-high-cardiovascular-risk
#5
C Rada, S Oummou, F Merzouk, B Amarir, G Boussabnia, H Bougrini, D Benzaroual, S Elkarimi, M Elhattaoui
INTRODUCTION: Peripheral arterial disease is a marker of systemic atherosclerosis; it is associated with a high risk of cardiovascular disease. The aim of our study was to assess the prevalence of peripheral arterial disease by measuring the ankle-brachial pressure index in patients at high cardiovascular risk and to study the risk factors associated with this disease. METHODOLOGY: This was a descriptive and analytic cross-sectional study which focused on 370 patients seen at the medical consultation for atherosclerosis prevention...
November 16, 2016: Journal des Maladies Vasculaires
https://www.readbyqxmd.com/read/27836295/circulating-osteogenic-endothelial-progenitor-cell-counts-new-biomarker-for-the-severity-of-coronary-artery-disease
#6
Shi-Wei Yang, Rebecca R Hennessy, Sundeep Khosla, Ryan Lennon, Darrell Loeffler, Tao Sun, Zhi Liu, Kyoung-Ha Park, Fei-Long Wang, Lilach O Lerman, Amir Lerman
BACKGROUND: There is increasing evidence implying that the early and functionally highly active circulating endothelial progenitor cell (CEPC) phenotype (CD34-/CD133+/KDR+) with osteogenic potential (OCN+) might link between vascular atherosclerotic calcification and mechanisms of bone metabolism. We sought to evaluate the early OCN+ CEPC counts as an independent biomarker for the severity of coronary artery disease (CAD). METHODS: Peripheral blood samples were drawn from 593 patients undergoing clinically indicated coronary angiography...
October 27, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27821353/time-dependent-differences-in-femoral-artery-plaque-characteristics-of-peripheral-arterial-disease-patients
#7
Saskia Haitjema, Steven T W van Haelst, Jean-Paul P M de Vries, Frans L Moll, Hester M den Ruijter, Gert J de Borst, Gerard Pasterkamp
BACKGROUND AND AIMS: Peripheral arterial disease (PAD) is a common manifestation of atherosclerosis with an increasing incidence worldwide. The disease is still associated with high morbidity and mortality risks. Previous research in carotid arteries indicates that atherosclerotic plaque characteristics have stabilized over time in patients considered for surgery. It is currently unknown whether this time-dependent stabilization occurs in ilio-femoral arteries as well. Our objective was to analyze whether local ilio-femoral atherosclerotic plaque characteristics have changed over time...
October 25, 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27789446/residential-proximity-to-traffic-related-pollution-and-atherosclerosis-in-4-vascular-beds-among-african-american-adults-results-from-the-jackson-heart-study
#8
Yi Wang, Gregory A Wellenius, DeMarc A Hickson, Annie Gjelsvik, Charles B Eaton, Sharon B Wyatt
To our knowledge, no study has investigated the association of long-term exposure to traffic pollution with markers of atherosclerosis in 4 vascular beds simultaneously in an all-African-American cohort. Among participants in the Jackson Heart Study (Jackson, Mississippi; baseline mean age = 55.5 (standard deviation, 12.7) years), we used linear regression to estimate percent differences in carotid intima-media thickness (CIMT) at baseline (2004) and used modified Poisson regression (robust error variance) to estimate prevalence ratios for peripheral artery disease (PAD), coronary artery calcification (CAC), and abdominal aortic calcification (AAC) at the first follow-up visit (2005-2008) for persons living less than 150 m (versus more than 300 m) from major roadways, adjusting for confounders...
October 27, 2016: American Journal of Epidemiology
https://www.readbyqxmd.com/read/27765310/local-ultrasound-to-enhance-paclitaxel-delivery-after-femoral-popliteal-treatment%C3%A2-in-critical-limb-ischemia-the-pacus-trial
#9
Roberto Gandini, Costantino Del Giudice
OBJECTIVES: The aim of this study was to evaluate the safety and efficacy of percutaneous catheter-delivered ultrasound energy to improve local paclitaxel delivery effects in patients with critical limb ischemia (CLI) treated for femoral-popliteal arterial disease. BACKGROUND: Treatment of patients with CLI continues to be the greatest challenge in peripheral artery disease; in particular, treatment of femoral-popliteal chronic total occlusion is characterized by poor primary patency...
October 24, 2016: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27753721/multidetector-64-computed-tomography-angiography-of-the-lower-limb-in-symptomatic-peripheral-arterial-disease-assessment-of-image-quality-and-accuracy-in-a-tertiary-care-setting
#10
Jeremy C Lim, Dinesh Ranatunga, Andrew Owen, Tim Spelman, Michael Galea, Jason Chuen, Ruth P Lim
OBJECTIVE: The aim of this study was to evaluate image quality and accuracy of 64+ detector multidetector computed tomography angiography (MDCTA) for hemodynamically significant (≥50%) stenosis in patients with symptomatic peripheral arterial disease (PAD) using digital subtraction angiography as the reference standard. METHODS: This is a retrospective study of 29 patients with PAD (19 men, 10 women) who underwent lower limb MDCTA (64- or 80-detector) and digital subtraction angiography...
October 7, 2016: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/27703657/lower-extremity-arterial-calcification-as-a-predictor-of-coronary-atherosclerosis-in-patients-with-peripheral-arterial-disease
#11
Hwa Seon Shin, Mi Jung Park, Kyung Nyeo Jeon, Jae Min Cho, Kyung Soo Bae, Dae Seob Choi, Jae Boem Na, Ho Cheol Choi, Hye Young Choi, Ji Eun Kim, Soo Bueum Cho, Sung Eun Park
BACKGROUND: Until now, there has been no study on the relationship between the calcification of the lower extremity arteries and significant coronary arterial disease (CAD). OBJECTIVES: To evaluate whether lower extremity calcium scores (LECS) are associated with CAD and whether this can predict multivessel-CAD in patients with peripheral arterial disease (PAD). PATIENTS AND METHODS: We retrospectively enrolled 103 PAD patients without cardiac symptoms or known CAD...
April 2016: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
https://www.readbyqxmd.com/read/27703086/emerging-risk-factors-for-recurrent-vascular-events-in-patients-with-embolic-stroke-of-undetermined-source
#12
Yuji Ueno, Kazuo Yamashiro, Ryota Tanaka, Takuma Kuroki, Kenichiro Hira, Naohide Kurita, Takao Urabe, Nobutaka Hattori
BACKGROUND AND PURPOSE: Underlying embolic causes diagnosed by transesophageal echocardiography could be implicated in mechanisms of embolic stroke of undetermined source. We aimed to explore factors, including underlying embolic causes, related to recurrent vascular events in embolic stroke of undetermined source. METHODS: Patients who fulfilled the diagnostic criteria for embolic stroke of undetermined source and whose potential embolic sources were examined by transesophageal echocardiography were included...
November 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27695492/subclinical-cardiovascular-disease-markers-and-vitamin-d-deficiency-in-non-dialysis-chronic-kidney-disease-patients
#13
Cristina Căpuşa, Gabriel Stefan, Simona Stancu, Andrea Ilyes, Nicoleta Dorobanţu, Gabriel Mircescu
INTRODUCTION: Since 25-hydroxyvitamin D (25(OH)D) deficiency has been linked to an increased risk for cardiovascular disease (CVD) in the hemodialysis population, we aimed to determine the relationship between serum 25(OH)D level and markers of subclinical CVD in non-dialysis chronic kidney disease (CKD) patients. MATERIAL AND METHODS: This cross-sectional, single-center study prospectively enrolled 87 clinically stable CKD patients (median age: 61 (57-66) years, 51% male, median estimated glomerular filtration rate (eGFR): 32 (27-37) ml/min)...
October 1, 2016: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/27667149/patients-with-diabetes-differ-in-atherosclerotic-plaque-characteristics-and-have-worse-clinical-outcome-after-iliofemoral-endarterectomy-compared-with-patients-without-diabetes
#14
Steven T W van Haelst, Saskia Haitjema, Jean-Paul P M de Vries, Frans L Moll, Gerard Pasterkamp, Hester M den Ruijter, Gert J de Borst
OBJECTIVE: Diabetes mellitus (DM) is associated with peripheral arterial disease (PAD) and leads to worse clinical outcome compared with patients without DM. The objective of this study was to determine the impact of DM on iliofemoral artery plaque characteristics and to examine secondary clinical outcomes in patients with DM and PAD undergoing surgical revascularization. METHODS: We analyzed 198 patients with and 453 patients without DM from the Athero-Express biobank, a prospective ongoing biobank study, who underwent endarterectomy of the femoral or iliac artery between 2002 and 2013...
September 22, 2016: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/27641942/starclose-se%C3%A2-hemostasis-after-6f-direct-antegrade-superficial-femoral-artery-access-distal-to-the-femoral-head-for-peripheral-endovascular-procedures-in-obese-patients
#15
Stavros Spiliopoulos, Panagiotis Kitrou, Nikolaos Christeas, Dimitris Karnabatidis
PURPOSE: Direct superficial femoral artery (SFA) antegrade puncture is a valid alternative to common femoral artery (CFA) access for peripheral vascular interventions. Data investigating vascular closure device (VCD) hemostasis of distant SFA 6F access are limited. We aimed to investigate the safety and effectiveness of the Starclose SE® VCD for hemostasis, following direct 6F antegrade SFA access distal to the femoral head. METHODS: This prospective, single-center study included patients who were not suitable for CFA puncture and were scheduled to undergo peripheral endovascular interventions using direct antegrade SFA 6F access, at least 2 cm below the inferior edge of femoral head...
November 2016: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/27636398/iliac-and-femoro-popliteal-arteries-morphological-cta-features-as-determinants-of-outcome-after-standard-evar-procedures
#16
Pasqualino Sirignano, Francesco Speziale, Laura Capoccia, Danilo Menna, Wassim Mansour, Nunzio Montelione, Francesco Setacci, Giuseppe Galzerano, Carlo Setacci
BACKGROUND: To evaluate the impact of iliac artery's diameters, tortuosity, and peripheral vascular patency on outcome of elective endovascular repair (EVAR) of abdominal aortic aneurysms (AAA) in 2 high volume vascular centers' experience. METHODS: A retrospective study was conducted on a prospectively collected database between 2010 and 2012. Anatomical features at pre-operative computed tomography (CTA) considered as potentially influencing outcomes were: iliac diameters, tortuosity (expressed as a ratio), and calcifications, bilateral internal iliac artery (IIA) patency, and presence of Trans-Atlantic Inter-Societies Consensus (TASC) II C/D femoro-popliteal occlusive disease (PAD)...
September 16, 2016: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/27626248/-clinical-peculiarities-of-atherosclerosis-of-peripheral-arteries-in-patients-with-abdominal-aortic-calcification
#17
M V Mel'nikov, V A Zelinskiĭ
The authors analysed clinical peculiarities of atherosclerosis of peripheral arteries (hereinafter referred to as APA) in patients presenting with abdominal aortic calcification (AAC). In order to determine the incidence rate of AAC in the population of patients with APA we analysed medical records of a total of 1,800 patients. The study itself included a total of 193 patients with APA further subdivided into two groups: 108 patients with AAC (Study Group) and 85 patients without AAC. Beside general clinical examination all patients were subjected to transthoracic echocardiography, duplex scanning of the aorta and lower-limb arteries, extended lipidogram and coagulogram...
2016: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/27608939/association-of-ankle-brachial-index-and-aortic-arch-calcification-with-overall-and-cardiovascular-mortality-in-hemodialysis
#18
Szu-Chia Chen, Mei-Yueh Lee, Jiun-Chi Huang, Ming-Chen Paul Shih, Jer-Ming Chang, Hung-Chun Chen
Peripheral artery occlusive disease and vascular calcification are highly prevalent in hemodialysis (HD) patients, however the association of the combination of ankle-brachial index (ABI) and aortic arch calcification (AoAC) with clinical outcomes in patients undergoing HD is unknown. In this study, we investigated whether the combination of ABI and AoAC is independently associated with overall and cardiovascular mortality in HD patients. The median follow-up period was 5.7 years. Calcification of the aortic arch was assessed by chest X-ray...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27601429/neurological-events-following-transcatheter-aortic-valve-replacement-and-their-predictors-a-report-from-the-corevalve-trials
#19
Neal S Kleiman, Brijeshwar J Maini, Michael J Reardon, John Conte, Stanley Katz, Vivek Rajagopal, James Kauten, Alan Hartman, Raymond McKay, Robert Hagberg, Jian Huang, Jeffrey Popma
BACKGROUND: The risk for stroke after transcatheter aortic valve replacement (TAVR) is an important concern. Identification of predictors for stroke is likely to be a critical factor aiding patient selection and management as TAVR use becomes widespread. METHODS AND RESULTS: Patients enrolled in the CoreValve US Extreme Risk and High Risk Pivotal Trials or Continued Access Study treated with the self-expanding CoreValve bioprosthesis were included in this analysis...
September 2016: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27598864/the-characteristics-of-retinal-emboli-and-its-association-with-vascular-reperfusion-in-retinal-artery-occlusion
#20
Kwan Hyuk Cho, Seong Joon Ahn, Joon Hee Cho, Cheolkyu Jung, Moon-Ku Han, Sang Jun Park, Kyu Hyung Park, Se Joon Woo
PURPOSE: To analyze the characteristics of retinal emboli and their association with vascular reperfusion in retinal artery occlusion (RAO). METHODS: In this retrospective comparative case series, we analyzed emboli in patients with acute central retinal artery occlusion (CRAO) or branch retinal artery occlusion (BRAO) and visible emboli, and analyzed vascular reperfusion in patients with visible emboli causing blockage of perfusion. The patients were divided into emboli "movement" and "no movement" groups and their vascular reperfusion states were compared...
September 1, 2016: Investigative Ophthalmology & Visual Science
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