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https://www.readbyqxmd.com/read/27933755/maternal-pre-pregnancy-bmi-downregulates-neonatal-cord-blood-lep-methylation
#1
R Kadakia, Y Zheng, Z Zhang, W Zhang, L Hou, J L Josefson
BACKGROUND: Neonatal adiposity has many determinants and may be a risk factor for future obesity. Epigenetic regulation of metabolically important genes is a potential contributor. OBJECTIVES: The objective of the study is to determine whether methylation changes in the LEP gene in cord blood DNA are impacted by the maternal environment or affect neonatal adiposity measures. METHODS: A cross-sectional study of 114 full-term neonates born to healthy mothers with normal glucose tolerance was performed...
December 8, 2016: Pediatric Obesity
https://www.readbyqxmd.com/read/27933523/integrative-functional-genomics-for-systems-genetics-in-geneweaver-org
#2
Jason A Bubier, Michael A Langston, Erich J Baker, Elissa J Chesler
The abundance of existing functional genomics studies permits an integrative approach to interpreting and resolving the results of diverse systems genetics studies. However, a major challenge lies in assembling and harmonizing heterogeneous data sets across species for facile comparison to the positional candidate genes and coexpression networks that come from systems genetic studies. GeneWeaver is an online database and suite of tools at www.geneweaver.org that allows for fast aggregation and analysis of gene set-centric data...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27933323/assessing-collagen-and-micro-permeability-at-the-proanthocyanidin-treated-resin-dentin-interface
#3
Berdan Aydin, Lina Saleh Hassan, Grace Viana, Ana K Bedran-Russo
PURPOSE: To establish a fluorescence-based method to simultaneously assess micro-permeability and collagen cross-linking induced by chemical agents at the resin-dentin interface. MATERIALS AND METHODS: Three chemical agents were investigated (proanthocyanidin-rich grape seed extract: GSE; carbodiimide hydrochloride/N-hydroxysuccinimide: EDC/NHS; glutaraldehyde: GD) along with a control (distilled water) as primers applied on flat occlusal dentin surfaces of 48 teeth and restored with two commercially available etch-and-rinse adhesives...
December 8, 2016: Journal of Adhesive Dentistry
https://www.readbyqxmd.com/read/27933095/direct-derivation-of-maize-plant-and-crop-height-from-low-cost-time-of-flight-camera-measurements
#4
Martin Hämmerle, Bernhard Höfle
BACKGROUND: In agriculture, information about the spatial distribution of crop height is valuable for applications such as biomass and yield estimation, or increasing field work efficiency in terms of fertilizing, applying pesticides, irrigation, etc. Established methods for capturing crop height often comprise restrictions in terms of cost and time efficiency, flexibility, and temporal and spatial resolution of measurements. Furthermore, crop height is mostly derived from a measurement of the bare terrain prior to plant growth and measurements of the crop surface when plants are growing, resulting in the need of multiple field campaigns...
2016: Plant Methods
https://www.readbyqxmd.com/read/27932950/amyloid-precursor-proteins-are-dynamically-trafficked-and-processed-during-neuronal-development
#5
Jenna M Ramaker, Robert S Cargill, Tracy L Swanson, Hanil Quirindongo, Marlène Cassar, Doris Kretzschmar, Philip F Copenhaver
Proteolytic processing of the Amyloid Precursor Protein (APP) produces beta-amyloid (Aβ) peptide fragments that accumulate in Alzheimer's Disease (AD), but APP may also regulate multiple aspects of neuronal development, albeit via mechanisms that are not well understood. APP is a member of a family of transmembrane glycoproteins expressed by all higher organisms, including two mammalian orthologs (APLP1 and APLP2) that have complicated investigations into the specific activities of APP. By comparison, insects express only a single APP-related protein (APP-Like, or APPL) that contains the same protein interaction domains identified in APP...
2016: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/27932916/taxonaut-an-application-software-for-comparative-display-of-multiple-taxonomies-with-a-use-case-of-gbif-species-api
#6
Nozomi Ytow
BACKGROUND: The Species API of the Global Biodiversity Information Facility (GBIF) provides public access to taxonomic data aggregated from multiple data sources. Each data source follows its own classification which can be inconsistent with classifications from other sources. Even with a reference classification e.g. the GBIF Backbone taxonomy, a comprehensive method to compare classifications in the data aggregation is essential, especially for non-expert users. NEW INFORMATION: A Java application was developed to compare multiple taxonomies graphically using classification data acquired from GBIF's ChecklistBank via the GBIF Species API...
2016: Biodiversity Data Journal
https://www.readbyqxmd.com/read/27932883/functional-cortical-changes-in-relapsing-remitting-multiple-sclerosis-at-amplitude-configuration-a-resting-state-fmri-study
#7
Heng Liu, Hua Chen, Bo Wu, Tijiang Zhang, Jinhui Wang, Kexin Huang, Ganjun Song, Jian Zhan
OBJECTIVE: The aim of this study was to explore the amplitude of spontaneous brain activity fluctuations in patients with relapsing-remitting multiple sclerosis (RRMS) using the amplitude of low-frequency fluctuation (ALFF) method. METHODS: ALFF and SPM8 were utilized to assess alterations in regional spontaneous brain activities in patients with RRMS in comparison with healthy controls (HCs). The beta values of altered brain regions between patients with RRMS and HCs were extracted, and a receiver operating characteristic (ROC) curve was generated to calculate the sensitivities and specificities of these different brain areas for distinguishing patients with RRMS from HCs...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27932665/statistical-analysis-of-a-low-cost-method-for-multiple-disease-prediction
#8
Mohsen Bayati, Sonia Bhaskar, Andrea Montanari
Early identification of individuals at risk for chronic diseases is of significant clinical value. Early detection provides the opportunity to slow the pace of a condition, and thus help individuals to improve or maintain their quality of life. Additionally, it can lessen the financial burden on health insurers and self-insured employers. As a solution to mitigate the rise in chronic conditions and related costs, an increasing number of employers have recently begun using wellness programs, which typically involve an annual health risk assessment...
December 8, 2016: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/27932410/anthropometric-factors-have-significant-influence-on-the-outcome-of-the-ghrh-arginine-test-establishment-of-normative-data-for-an-automated-immunoassay-specifically-measuring-22kd-human-growth-hormone
#9
Timo Deutschbein, Martin Bidlingmaier, Jochen Schopohl, Christian J Strasburger, Stephan Petersenn
CONTEXT: Adult growth hormone (GH) deficiency (GHD) is diagnosed by provocative testing of GH secretion. OBJECTIVE: To improve diagnostic accuracy of GH releasing hormone (GHRH) plus arginine (GARG) testing, we evaluated the influence of age, BMI, and sex, and established normative data for an automatic immunoassay specifically measuring 22kD human GH. DESIGN/SETTING: Prospective multicenter study. PARTICIPANTS: Eighty-seven patients with hypothalamic-pituitary disease and 200 healthy controls...
December 8, 2016: European Journal of Endocrinology
https://www.readbyqxmd.com/read/27932267/human-pre-pik3c2b-an-intronic-cis-element-with-dual-function-of-activation-and-repression
#10
Jayant Maini, Mohsen Ghasemi, Deepti Yandhuri, Suman S Thakur, Vani Brahmachari
The Polycomb/Trithorax Responsive Elements (PRE/TREs) are the cis-regulatory sequences that interact with both repressive (PcG) as well as activating (TrxG) complexes. However, most of the mammalian PREs are demonstrated to interact with the repressive polycomb (PcG) complexes only. We have carried out an unbiased search for proteins interacting with human PRE-PIK3C2B (hPRE-PIK3C2B) based on DNA affinity purification followed by mass spectrometry and identified MLL, MLL4 and WDR87 among other proteins in three biological replicates in HEK, U87 and HeLa cell lines...
December 5, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27931984/knowledge-about-sources-of-dietary-fibres-and-health-effects-using-a-validated-scale-a-cross-country-study
#11
R P F Guiné, J Duarte, M Ferreira, P Correia, M Leal, I Rumbak, I C Barić, D Komes, Z Satalić, M M Sarić, M Tarcea, Z Fazakas, D Jovanoska, D Vanevski, E Vittadini, N Pellegrini, V Szűcs, J Harangozó, A El-Kenawy, O El-Shenawy, E Yalçın, C Kösemeci, D Klava, E Straumite
OBJECTIVES: Dietary fibre (DF) is one of the components of diet that strongly contributes to health improvements, particularly on the gastrointestinal system. Hence, this work intended to evaluate the relations between some sociodemographic variables such as age, gender, level of education, living environment or country on the levels of knowledge about dietary fibre (KADF), its sources and its effects on human health, using a validated scale. STUDY DESIGN: The present study was a cross-sectional study...
December 2016: Public Health
https://www.readbyqxmd.com/read/27931702/peripheral-nerve-blocks-causing-increased-risk-for-fall-and-difficulty-in-ambulation-for-the-hip-and-knee-joint-replacement-patient
#12
Bonnie L Crumley Aybar, Michael J Gillespie, Sean F Gipson, Caitlin E Mullaney, Melissa Tommasino-Storz
A systematic review of the literature was completed by the Evidence-Based Practice Group for the Patient population, Intervention/Issue, Comparison Intervention, Outcomes, Timing (PICOT) question: "Does the use of a peripheral nerve block increase the risk for falls and difficulty ambulation in patients after lower extremity surgery through postoperative day 2?" A search of multiple databases using specified key terms resulted in 258 articles for total knee arthroplasty or total hip arthroplasty. These were reduced to 13 with exclusion criteria and became primary evidence...
December 2016: Journal of Perianesthesia Nursing: Official Journal of the American Society of PeriAnesthesia Nurses
https://www.readbyqxmd.com/read/27930376/excimer-light-treatment-for-idiopathic-guttate-hypomelanosis-a-pilot-study
#13
Jennifer R S Gordon, Kellie E Reed, Katherine R Sebastian, Ammar M Ahmed
BACKGROUND: Idiopathic guttate hypomelanosis (IGH) is a commonly acquired benign leukoderma characterized by multiple discrete, hypo- or depigmented macules often on extremities that can be aesthetically undesirable for patients. This is the first study using excimer laser for treatment. OBJECTIVE: To determine the effectiveness of excimer laser for repigmentation of idiopathic guttate hypomelanosis. METHODS AND MATERIALS: In this longitudinal, split-body controlled, single-blinded pilot study, 6 patients were treated with excimer laser for 12 weeks using the vitiligo protocol...
December 2, 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/27930367/multiple-comparisons-using-composite-likelihood-in-clustered-data
#14
Mahdis Azadbakhsh, Xin Gao, Hanna Jankowski
We study the problem of multiple hypothesis testing for correlated clustered data. As the existing multiple comparison procedures based on maximum likelihood estimation could be computationally intensive, we propose to construct multiple comparison procedures based on composite likelihood method. The new test statistics account for the correlation structure within the clusters and are computationally convenient to compute. Simulation studies show that the composite likelihood based procedures maintain good control of the familywise type I error rate in the presence of intra-cluster correlation, whereas ignoring the correlation leads to erratic performance...
November 1, 2016: International Journal of Biostatistics
https://www.readbyqxmd.com/read/27929924/effect-of-different-agitation-techniques-on-the-penetration-of-irrigant-and-sealer-into-dentinal-tubules
#15
Yu Gu, Hiran Perinpanayagam, David J W Kum, Yeon-Jee Yoo, Jin-Sun Jeong, Sang-Min Lim, Seok-Woo Chang, Seung-Ho Baek, Qiang Zhu, Kee-Yeon Kum
OBJECTIVE: The aim of this study was to compare the effectiveness of five intracanal agitation techniques on the penetration of irrigant and sealer into dentinal tubules. BACKGROUND DATA: Intracanal agitation techniques could promote chemomechanical debridement and the sealing of root canals during endodontic treatment. However, there is limited evidence for the agitation effect of Nd:YAP laser. MATERIALS AND METHODS: Human maxillary premolars with single straight canals (N = 60) were prepared with ProTaper Next(®) NiTi rotary files (Dentsply Maillefer) up to X4 (ISO 40 size)...
November 3, 2016: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/27929690/comparison-of-the-center-for-epidemiology-studies-depression-scale-and-beck-depression-inventory-for-research-with-latinas
#16
Melinda Bogardus
U.S. Latino farmworkers face multiple potential stressors. Research on the mental health status of this U.S. Latino subgroup has suggested high prevalence of stress, anxiety, and depressive symptoms when compared to other groups. Latina farmworkers may be at greater risk than their male counterparts for poor mental health because they confront many of the same stressors but may experience additional difficulties including domestic violence, taking on new roles and responsibilities on top of traditional ones, and being expected to maintain the health and integrity of their families at the expense of their own needs...
December 8, 2016: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/27928688/combining-laser-doppler-flowmetry-measurements-with-spectral-analysis-to-study-different-microcirculatory-effects-in-human-prediabetic-and-diabetic-subjects
#17
Hsiao-Feng Hu, Hsin Hsiu, Ciao-Jyuan Sung, Chien-Hsing Lee
We aimed to identify the microcirculatory regulatory mechanisms in diabetic and prediabetic humans using a noninvasive method combining spectral analysis with laser-Doppler flowmetry (LDF) measurements on the skin surface. LDF signals were measured by a moorVMS-LDF device to measure the microcirculatory blood flow flux with a time constant of 0.001 s, a cutoff frequency of 14.9 kHz, and a sampling frequency of 40 Hz. The laser operating wavelength and output power were 400-700 nm and 6 mW, respectively...
December 7, 2016: Lasers in Medical Science
https://www.readbyqxmd.com/read/27928628/calcium-41-a-technology-for-monitoring-changes-in-bone-mineral
#18
REVIEW
C M Weaver, B R Martin, G S Jackson, G P McCabe, M Peacock, M Wastney
The rare, long-lived radiotracer, (41)Ca, measured by accelerator mass spectrometry in the urine or serum following incorporation into the bone provides an ultra-sensitive tool to assess changes in bone calcium balance in response to an intervention. Changes in bone balance can be followed for years with one small dose that is both radiologically and biologically non-invasive. Sequential interventions can be compared, with greater precision than they can with biochemical markers of bone turnover and with greater power than with bone densitometry...
December 7, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27928507/life-history-linked-to-immune-investment-in-developing-amphibians
#19
Douglas C Woodhams, Sara C Bell, Laurent Bigler, Richard M Caprioli, Pierre Chaurand, Brianna A Lam, Laura K Reinert, Urs Stalder, Victoria M Vazquez, Klaus Schliep, Andreas Hertz, Louise A Rollins-Smith
The broad diversity of amphibian developmental strategies has been shaped, in part, by pathogen pressure, yet trade-offs between the rate of larval development and immune investment remain poorly understood. The expression of antimicrobial peptides (AMPs) in skin secretions is a crucial defense against emerging amphibian pathogens and can also indirectly affect host defense by influencing the composition of skin microbiota. We examined the constitutive or induced expression of AMPs in 17 species at multiple life-history stages...
2016: Conservation Physiology
https://www.readbyqxmd.com/read/27927941/a-population-based-epidemiologic-study-of-adult-neuromuscular-disease-in-the-republic-of-ireland
#20
Stela Lefter, Orla Hardiman, Aisling M Ryan
OBJECTIVE: To estimate the prevalence rates (PRs) of acquired and inherited neuromuscular diseases (NMD) in the adult Irish population, reflecting the burden of these conditions in a single country. METHODS: This population-based study was performed in the Republic of Ireland (RoI), with a PR estimated for December 2013. Multiple case ascertainment sources were utilized. Demographic and clinical information and relevant diagnostic results were registered. RESULTS: A total of 2,641 adults were identified, giving a PR of 62...
December 7, 2016: Neurology
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