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JOURNAL ARTICLE
Alper Ozdogan, Büsra Tosun
BACKGROUND: As polyether ether ketone (PEEK) is a relatively new material in dentistry, its bonding properties with regard to dental acrylic base materials are not fully known. To ensure the long-term success of removable dentures with a PEEK framework, the base materials must be well bonded to each other. OBJECTIVES: The study aimed to investigate the effects of different kinds of surface roughening treatment on PEEK and acrylic resin bonding. MATERIAL AND METHODS: Eighty PEEK specimens (N = 80) were randomly divided into 5 groups (n = 16 per group) and subjected to various surface roughening treatment (control, grinding, sandblasting, tribochemical silica coating (CoJet), and sulfuric acid etching)...
2024: Dental and Medical Problems
#2
JOURNAL ARTICLE
Soo Heon Kwak, Ryan B Hernandez-Cancela, Daniel A DiCorpo, David E Condon, Jordi Merino, Peitao Wu, Jennifer A Brody, Jie Yao, Xiuqing Guo, Fariba Ahmadizar, Mariah Meyer, Murat Sincan, Josep M Mercader, Sujin Lee, Jeffrey Haessler, Ha My T Vy, Zhaotong Lin, Nicole D Armstrong, Shaopeng Gu, Noah L Tsao, Leslie A Lange, Ningyuan Wang, Kerri L Wiggins, Stella Trompet, Simin Liu, Ruth J F Loos, Renae Judy, Philip H Schroeder, Natalie R Hasbani, Maxime M Bos, Alanna C Morrison, Rebecca D Jackson, Alexander P Reiner, JoAnn E Manson, Ninad S Chaudhary, Lynn K Carmichael, Yii-Der Ida Chen, Kent D Taylor, Mohsen Ghanbari, Joyce van Meurs, Achilleas N Pitsillides, Bruce M Psaty, Raymond Noordam, Ron Do, Kyong Soo Park, J Wouter Jukema, Maryam Kavousi, Adolfo Correa, Stephen S Rich, Scott M Damrauer, Catherine Hajek, Nam H Cho, Marguerite R Irvin, James S Pankow, Girish N Nadkarni, Robert Sladek, Mark O Goodarzi, Jose C Florez, Daniel I Chasman, Susan R Heckbert, Charles Kooperberg, Josée Dupuis, Rajeev Malhotra, Paul S de Vries, Ching-Ti Liu, Jerome I Rotter, James B Meigs
OBJECTIVE: To identify genetic risk factors for incident cardiovascular disease (CVD) among people with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS: We conducted a multiancestry time-to-event genome-wide association study for incident CVD among people with T2D. We also tested 204 known coronary artery disease (CAD) variants for association with incident CVD. RESULTS: Among 49,230 participants with T2D, 8,956 had incident CVD events (event rate 18...
April 23, 2024: Diabetes Care
#3
COMPARATIVE STUDY
Chung-You Tsai, Shang-Ju Hsieh, Hung-Hsiang Huang, Juinn-Horng Deng, Yi-You Huang, Pai-Yu Cheng
PURPOSE: To compare ChatGPT-4 and ChatGPT-3.5's performance on Taiwan urology board examination (TUBE), focusing on answer accuracy, explanation consistency, and uncertainty management tactics to minimize score penalties from incorrect responses across 12 urology domains. METHODS: 450 multiple-choice questions from TUBE(2020-2022) were presented to two models. Three urologists assessed correctness and consistency of each response. Accuracy quantifies correct answers; consistency assesses logic and coherence in explanations out of total responses, alongside a penalty reduction experiment with prompt variations...
April 23, 2024: World Journal of Urology
#4
JOURNAL ARTICLE
Emilio Fernandez-Egea, Shanquan Chen, Estela Sangüesa, Patricia Gassó, Marjan Biria, James Plaistow, Isaac Jarratt-Barnham, Nuria Segarra, Sergi Mas, Maria-Pilar Ribate, Cristina B García, Naomi A Fineberg, Yulia Worbe, Rudolf N Cardinal, Trevor W Robbins
BACKGROUND: A significant proportion of people with clozapine-treated schizophrenia develop 'checking' compulsions, a phenomenon yet to be understood. AIMS: To use habit formation models developed in cognitive neuroscience to investigate the dynamic interplay between psychosis, clozapine dose and obsessive-compulsive symptoms (OCS). METHOD: Using the anonymised electronic records of a cohort of clozapine-treated patients, including longitudinal assessments of OCS and psychosis, we performed longitudinal multi-level mediation and multi-level moderation analyses to explore associations of psychosis with obsessiveness and excessive checking...
May 2024: British Journal of Psychiatry
#5
JOURNAL ARTICLE
Megan Zercher, Jason A Coral, Diane Nabb, Griselda Powers, Alan Jones, Karla Johanning
Bioaccumulation predictions can be substantially improved by combining in vitro metabolic rate measurements derived from rainbow trout hepatocytes and/or hepatic S9 fractions with quantitative structure-activity relationship (QSAR) modeling approaches. Compared with in vivo testing guidelines Organisation for Economic Co-operation and Development (OECD) 305 and Office of Chemical Safety and Pollution Prevention (OCSPP; an office of the US Environmental Protection Agency) 850.1730, the recently adopted OECD test guidelines 319A and 319B are in vitro approaches that have the potential to provide a time- and cost-efficient, humane solution, reducing animal use while addressing uncertainties in bioaccumulation across species...
April 23, 2024: Environmental Toxicology and Chemistry
#6
JOURNAL ARTICLE
Sourat Darabi, Tolulope Adeyelu, Andrew Elliott, Ammar Sukari, Kurt Hodges, Farah Abdulla, Carlos E Zuazo, Trisha Wise-Draper, Thomas Wang, Michael J Demeure
BACKGROUND: About 75% of medullary thyroid cancers (MTCs) are sporadic with 45-70% being driven by a RET mutation. Selpercatinib is an approved treatment for RET-mutated (mutRET) MTC, however, treatments are needed for wild-type RET MTC (wtRET). Genomic alterations and transcriptomic signatures of wtRET MTC may reveal new therapeutic insights. METHODS: We did a retrospective analysis of MTC samples submitted for DNA/RNA sequencing and PD-L1 expression using IHC at a CLIA/CAP-certified lab...
April 23, 2024: Journal of the American College of Surgeons
#7
JOURNAL ARTICLE
Continuous Shear Wave Elastography for Liver Using Frame-to-Frame Equalization of Complex Amplitude.
Naoki Tano, Ren Koda, Shunichiro Tanigawa, Naohisa Kamiyama, Yoshiki Yamakoshi, Marie Tabaru
This study addresses a crucial necessity in the field of noninvasive liver fibrosis diagnosis by introducing the concept of continuous shear wave elastography (C-SWE), utilizing an external vibration source and color Doppler imaging. However, an application of C-SWE to assess liver elasticity, a deep region within the human body, arises an issue of signal instability in the obtained data. To tackle this challenge, this work proposes a method involving the acquisition of multiple frames of datasets, which are subsequently compressed...
April 23, 2024: Ultrasonic Imaging
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JOURNAL ARTICLE
José A Bragada, Pedro M Magalhães, Eric São-Pedro, Raul F Bartolomeu, Jorge E Morais
The aim of this study was to verify the accuracy of predicting oxygen consumption (O2 ) in predominantly aerobic activities based on net heart rate (netHR), sex, and body mass index (BMI) in active adults. NetHR is the value of the difference between the resting HR (HRrest ) and the average HR value obtained during a given session or period of physical activity. These activities must be continuous, submaximal, and of a stabilized intensity. The magnitude of the netHR depends mainly on the intensity of the exercise...
April 7, 2024: Journal of Functional Morphology and Kinesiology
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REVIEW
Tanya Andersson Nystedt, Tobias Herder, Anette Agardh, Benedict Oppong Asamoah
BACKGROUND: Growing evidence indicates that young migrants are particularly vulnerable to sexual violence, however most research has focused on instances of sexual violence occurring in conflict zones and during transit. Much less attention has been given to the vulnerabilities to and experiences of sexual violence among young migrants in Europe. OBJECTIVES: To understand the scientific evidence regarding the experiences of and vulnerabilities to sexual violence among young migrants (aged 11-30 years) in Europe...
December 31, 2024: Global Health Action
#10
JOURNAL ARTICLE
Khalid W Taher, Rahaf Yaseen, Mayas Alnan, Wejdan Aburas, Hala Khalil, Moath Alabdulsalam
INTRODUCTION: Gastrointestinal bleeding (GI) is a prevalent condition among pediatric patients, with a reported incidence of 6.4%, often severe enough to require admission to the pediatric intensive care unit (PICU). There are multiple therapies utilized in the management of GI bleeding in pediatrics, among which continuous intravenous (IV) infusion of omeprazole is used off-label without standard pediatric dosing recommendations. Reviewing the current literature reveals a lack of studies assessing the efficacy, safety, and appropriate dosing regimen of continuous omeprazole infusion in children with GI bleeding...
2024: Frontiers in Pediatrics
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JOURNAL ARTICLE
Gabriel Hundeshagen, Elisabeth Blears, Viktoria Mertin, Andrew G Day, Alen Palackic, Christian Tapking, Valentin Haug, Ulrich Kneser, Björn Bliesener, Adriana C Panayi, Ariel Aballay, Francois Depret, Christian Stoppe, Daren K Heyland
BACKGROUND: Prospective randomized trials in severely burned children have shown the positive effects of oxandrolone (OX), beta blockers (BB) and a combination of the two (BBOX) on hypermetabolism, catabolism and hyperinflammation short- and long-term post-burn. Although data on severely burned adults are lacking in comparison, BB, OX and BBOX appear to be commonly employed in this patient population. In this study, we perform a secondary analysis of an international prospective randomized trial dataset to provide descriptive evidence regarding the current utilization patterns and potential treatment effects of OX, BB and BBOX...
2024: Burns and Trauma
#12
JOURNAL ARTICLE
Dong-Kun Xie, Jin Yao, Peng-Hui Li, Yan-Wen Zhu, Jia-Nuo Chen, Xiu-Li Cao, Shi-Lin Cheng, Ya-Miao Chen, Yi-Fei Huang, Liang Wang, Zan-Han Wang, Rong Qiao, Jia-Mei Ge, Huan Yue, Li Wei, Zhong-Yuan Liu, Hua Han, Hong-Yan Qin, Jun-Long Zhao
INTRODUCTION: Macrophages are an important component of innate immunity and involved in the immune regulation of multiple diseases. The functional diversity and plasticity make macrophages to exhibit different polarization phenotypes after different stimuli. During tumor progression, the M2-like polarized tumor-associated macrophages (TAMs) promote tumor progression by assisting immune escape, facilitating tumor cell metastasis, and switching tumor angiogenesis. Our previous studies demonstrated that functional remodeling of TAMs through engineered-modifying or gene-editing provides the potential immunotherapy for tumor...
2024: Frontiers in Immunology
#13
JOURNAL ARTICLE
Lisa Yun, Robert Zegarac, Daniel C Ducat
Cyanobacteria have been proposed as a potential alternative carbohydrate feedstock and multiple species have been successfully engineered to secrete fermentable sugars. To date, the most productive cyanobacterial strains are those designed to secrete sucrose, yet there exist considerable differences in reported productivities across different model species and laboratories. In this study, we investigate how cultivation conditions (specifically, irradiance, CO2 , and cultivator type) affect the productivity of sucrose-secreting Synechococcus elongatus PCC 7942...
2024: Frontiers in Plant Science
#14
JOURNAL ARTICLE
Shenghua Fan, Laura L Georgi, Frederick V Hebard, Tetyana Zhebentyayeva, Jiali Yu, Paul H Sisco, Sara F Fitzsimmons, Margaret E Staton, Albert G Abbott, C Dana Nelson
Chestnut blight (caused by Cryphonectria parasitica ), together with Phytophthora root rot (caused by Phytophthora cinnamomi ), has nearly extirpated American chestnut ( Castanea dentata ) from its native range. In contrast to the susceptibility of American chestnut, many Chinese chestnut ( C. mollissima ) genotypes are resistant to blight. In this research, we performed a series of genome-wide association studies for blight resistance originating from three unrelated Chinese chestnut trees (Mahogany, Nanking and M16) and a Quantitative Trait Locus (QTL) study on a Mahogany-derived inter-species F2 family...
2024: Frontiers in Plant Science
#15
JOURNAL ARTICLE
R Kasyan G, A Khodyreva L, L Grigoryan B, V Dyakov V
AIM: The aim of the observational cohort study is to study and evaluate the efficiency of the drug Adenoprosin in combination with other drugs in comparison with monotherapy. MATERIALS AND METHODS: Data from 6,442 patients at 221 medical institutions in 39 cities from November 2020 to December 2022 were analyzed. The drug Adenoprosin in the form of rectal suppositories was prescribed as monotherapy in group I, while patients in group II received Adenoprosin in a combination with other drugs...
March 2024: Urologii︠a︡
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JOURNAL ARTICLE
Elie E Daou, Pascale Salameh
AIMS: The objectives of the study were to compare the adaptation of presintered zirconia and cobalt- chromium prostheses using microcomputed tomography (μCT), scanning electron microscopy (SEM), and stereomicroscope (SM). MATERIALS AND METHODS: Twenty-four fixed dental prostheses (FDPs) were fabricated on metal abutments, duplicated from maxillary first premolar and first molar prepared on a typodont model. Teeth were reduced to obtain chamfer of 1.2 mm and reduction occlusaly of 2 mm occlusal...
April 1, 2024: Journal of Indian Prosthodontic Society
#17
JOURNAL ARTICLE
Manupreet Kaur, Shailendra Kumar Sahu
AIM: The main aim of the present study was to compare and evaluate the effect of repetitive firings on different shades of a pressable all ceramic system layered with veneering porcelain. SETTING AND DESIGN: In-vitro comparative study. MATERIALS AND METHODS: An in vitro comparative study was conducted, and a total of 60 disc shaped specimens (15 mm in diameter and 0.8 mm in thickness) were made of heat pressed ceramic of shades A2, A3, and B2 (20 discs of each shade) grouped as Group I, II, and III, respectively, using the lost wax technique...
April 1, 2024: Journal of Indian Prosthodontic Society
#18
JOURNAL ARTICLE
Simon Reichert, Victor Schepkin, Dennis Kleimaier, Frank G Zöllner, Lothar R Schad
PURPOSE: Sodium triple quantum (TQ) signal has been shown to be a valuable biomarker for cell viability. Despite its clinical potential, application of Sodium TQ signal is hindered by complex pulse sequences with long scan times. This study proposes a method to approximate the TQ signal using a single excitation pulse without phase cycling. METHODS: The proposed method is based on a single excitation pulse and a comparison of the free induction decay (FID) with the integral of the FID combined with a shifting reconstruction window...
April 22, 2024: Magnetic Resonance in Medicine
#19
JOURNAL ARTICLE
Sara Ezzat, Magda I Mohamad, Manal Basyouni Ahmed, Sara Elsayed Abdelrahman, Nesma Hussein Abdel Hay, Nashwa El-Khazragy, Maha Imam Ismail
MiRNA 200-c-3p has varying functions in different tumor types, whether tumor suppression or promotion. Comprehensive assessment of its function in non-small cell lung cancer (NSCLC) together with its effect on antitumor immune response have not been declared before. We aimed to explore the effect of replacement and suppression of miRNA 200-c-3p on non-small cell lung cancer and its impact on immune checkpoint function and subsequently antitumor immunity. MiRNA 200-c-3p mimic/inhibitor was transfected into the A549 cells...
March 31, 2024: Cellular and Molecular Biology
#20
JOURNAL ARTICLE
Tobias Albrecht, Nathalie Fehre, Wolf Ramackers, Christoph Nikendei, Christian Offergeld
BACKGROUND: The study aimed to assess the impact of different training modalities on otoscopy performance during a practical exam using a high-fidelity simulator and to determine if objective evaluation of otoscopy is feasible using a simulator that records insertion depth and tympanic membrane coverage. METHODS: Participants were assigned to one of four groups: control and three intervention groups with varying training approaches. Participants received otoscopy training and then were assessed through a practical exam on a high-fidelity simulator that uses virtual reality to visualize the ear canal and middle ear...
April 22, 2024: BMC Medical Education
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