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Resting state networks

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https://www.readbyqxmd.com/read/29222835/effective-network-of-deep-brain-stimulation-of-subthalamic-nucleus-with-bimodal-positron-emission-tomography-functional-magnetic-resonance-imaging-in-parkinson-s-disease
#1
Hui-Min Chen, Zhi-Qiang Sha, Hui-Zi Ma, Yong He, Tao Feng
AIMS: Deep brain stimulation of the subthalamic nucleus (STN-DBS) has become an effective treatment strategy for patients with Parkinson's disease. However, the biological mechanism underlying DBS treatment remains poorly understood. METHOD: In this study, we investigated how STN-DBS modulated the brain network using a bimodal positron emission tomography (PET)/functional magnetic resonance imaging (fMRI) dataset. We first performed an activation likelihood estimation meta-analysis of 13 PET/SPECT studies concerning STN-DBS effects on resting-state brain activity in Parkinson's disease...
December 8, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29222818/task-related-effective-connectivity-reveals-that-the-cortical-rich-club-gates-cortex-wide-communication
#2
Mario Senden, Niels Reuter, Martijn P van den Heuvel, Rainer Goebel, Gustavo Deco, Matthieu Gilson
Higher cognition may require the globally coordinated integration of specialized brain regions into functional networks. A collection of structural cortical hubs-referred to as the rich club-has been hypothesized to support task-specific functional integration. In the present paper, we use a whole-cortex model to estimate directed interactions between 68 cortical regions from functional magnetic resonance imaging activity for four different tasks (reflecting different cognitive domains) and resting state. We analyze the state-dependent input and output effective connectivity (EC) of the structural rich club and relate these to whole-cortex dynamics and network reconfigurations...
December 8, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/29222816/shyness-and-trajectories-of-functional-network-connectivity-over-early-adolescence
#3
Chad M Sylvester, Diana J Whalen, Andy C Belden, Shana L Sanchez, Joan L Luby, Deanna M Barch
High shyness during early adolescence is associated with impaired peer relationships and risk for psychiatric disorders. Little is known, however, about the relation between shyness and trajectories of brain development over early adolescence. The current study longitudinally examined trajectories of resting-state functional connectivity (rs-fc) within four brain networks in 147 adolescents. Subjects underwent functional magnetic resonance imaging at three different time points, at average ages 10.5 (range = 7...
December 8, 2017: Child Development
https://www.readbyqxmd.com/read/29220695/altered-resting-state-functional-connectivity-in-early-course-schizophrenia
#4
Aastha Sharma, Arvind Kumar, Sadhana Singh, Triptish Bhatia, R P Beniwal, Subash Khushu, Konasale M Prasad, Smita N Deshpande
Impaired connectivity is proposed to underlie pathophysiology of schizophrenia. Existing studies on functional connectivity show inconsistent results. We examined functional connectivity in a clinically homogenous sample of 34 early course schizophrenia patients compared with/to 19 healthy controls using resting state functional magnetic resonance imaging (rsfMRI). Mean duration of illness for schizophrenia patients was 4 ± 1.78 years. Following a comprehensive clinical assessment, rsfMRI data were acquired using a 3...
November 22, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29218892/heritability-estimates-on-resting-state-fmri-data-using-enigma-analysis-pipeline
#5
Bhim M Adhikari, Neda Jahanshad, Dinesh Shukla, David C Glahn, John Blangero, Richard C Reynolds, Robert W Cox, Els Fieremans, Jelle Veraart, Dmitry S Novikov, Thomas E Nichols, L Elliot Hong, Paul M Thompson, Peter Kochunov
Big data initiatives such as the Enhancing NeuroImaging Genetics through Meta-Analysis consortium (ENIGMA), combine data collected by independent studies worldwide to achieve more generalizable estimates of effect sizes and more reliable and reproducible outcomes. Such efforts require harmonized image analyses protocols to extract phenotypes consistently. This harmonization is particularly challenging for resting state fMRI due to the wide variability of acquisition protocols and scanner platforms; this leads to site-to-site variance in quality, resolution and temporal signal-to-noise ratio (tSNR)...
2018: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/29218874/large-scale-analysis-of-disease-pathways-in-the-human-interactome
#6
Monica Agrawal, Marinka Zitnik, Jure Leskovec
Discovering disease pathways, which can be defined as sets of proteins associated with a given disease, is an important problem that has the potential to provide clinically actionable insights for disease diagnosis, prognosis, and treatment. Computational methods aid the discovery by relying on protein-protein interaction (PPI) networks. They start with a few known disease-associated proteins and aim to find the rest of the pathway by exploring the PPI network around the known disease proteins. However, the success of such methods has been limited, and failure cases have not been well understood...
2018: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/29213031/-neuronet-restructuring-in-focal-and-generalized-epilepsy-according-to-resting-state-fmri
#7
L A Mayorova, I S Samotaeva, N N Lebedeva, R V Luzin, V V Gaskin, F K Rider, A M Teplyshova, R G Akzhigitov, A B Guekht
AIM: To compare neuronet restructuring in focal and generalized epilepsy. MATERIAL AND METHODS: Seventy-seven patients, aged from 18 to 65 years, with the diagnosis of epilepsy, including 63 patients with focal epilepsy and 14 with generalized epilepsy, were examined. A control group included 23 healthy people. Neuronet restructuring was studied using fMRI. RESULTS AND CONCLUSION: According to resting state fMRI, there were between-group differences in spatial organization (activity map) of the brain structures as well as in the results of cross-correlation analysis of interaction maps of resting-state networks...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29212542/a-framework-to-find-the-logic-backbone-of-a-biological-network
#8
Parul Maheshwari, Réka Albert
BACKGROUND: Cellular behaviors are governed by interaction networks among biomolecules, for example gene regulatory and signal transduction networks. An often used dynamic modeling framework for these networks, Boolean modeling, can obtain their attractors (which correspond to cell types and behaviors) and their trajectories from an initial state (e.g. a resting state) to the attractors, for example in response to an external signal. The existing methods however do not elucidate the causal relationships between distant nodes in the network...
December 6, 2017: BMC Systems Biology
https://www.readbyqxmd.com/read/29211655/spectral-diversity-in-default-mode-network-connectivity-reflects-behavioral-state
#9
Michael M Craig, Anne E Manktelow, Barbara J Sahakian, David K Menon, Emmanuel A Stamatakis
Default mode network (DMN) functional connectivity is thought to occur primarily in low frequencies (<0.1 Hz), resulting in most studies removing high frequencies during data preprocessing. In contrast, subtractive task analyses include high frequencies, as these are thought to be task relevant. An emerging line of research explores resting fMRI data at higher-frequency bands, examining the possibility that functional connectivity is a multiband phenomenon. Furthermore, recent studies suggest DMN involvement in cognitive processing; however, without a systematic investigation of DMN connectivity during tasks, its functional contribution to cognition cannot be fully understood...
December 6, 2017: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/29210942/auditory-related-resting-state-fmri-functional-connectivity-in-tinnitus-patients-tinnitus-diagnosis-performance
#10
Shujiro B Minami, Naoki Oishi, Takahisa Watabe, Kimiichi Uno, Kaoru Ogawa
OBJECTIVE: The purpose of the present study was to investigate functional connectivity in tinnitus patients with and without hearing loss, and design the tinnitus diagnosis performance by resting state functional magnetic resonance imaging (rs-fMRI). SUBJECTS AND METHODS: Nineteen volunteers with normal hearing without tinnitus, 18 tinnitus patients with hearing loss, and 11 tinnitus patients without hearing loss were enrolled in this study. The subjects were evaluated with rs-fMRI, and region of interests (ROIs) based correlation analyses were performed using the CONN toolbox version 16 and SPM version 8...
November 28, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/29209238/disrupted-control-related-functional-brain-networks-in-drug-naive-children-with-attention-deficit-hyperactivity-disorder
#11
Jiejie Tao, Xueyan Jiang, Xin Wang, Huiru Liu, Andan Qian, Chuang Yang, Hong Chen, Jiance Li, Qiong Ye, Jinhui Wang, Meihao Wang
Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disease featuring executive control deficits as a prominent neuropsychological trait. Executive functions are implicated in multiple sub-networks of the brain; however, few studies examine these sub-networks as a whole in ADHD. By combining resting-state functional MRI and graph-based approaches, we systematically investigated functional connectivity patterns among four control-related networks, including the frontoparietal network (FPN), cingulo-opercular network, cerebellar network, and default mode network (DMN), in 46 drug-naive children with ADHD and 31 age-, gender-, and intelligence quotient-matched healthy controls (HCs)...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29209234/altered-brain-functional-connectivity-in-betel-quid-dependent-chewers
#12
Xiaojun Huang, Weidan Pu, Haihong Liu, Xinmin Li, Andrew J Greenshaw, Serdar M Dursun, Zhimin Xue, Zhening Liu
Background: Betel quid (BQ) is a common psychoactive substance worldwide with particularly high usage in many Asian countries. This study aimed to explore the effect of BQ use on functional connectivity by comparing global functional brain networks and their subset between BQ chewers and healthy controls (HCs). Methods: Resting-state functional magnetic resonance imaging (fMRI) was obtained from 24 betel quid-dependent (BQD) male chewers and 27 healthy male individuals on a 3...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29209197/asymmetry-of-hemispheric-network-topology-reveals-dissociable-processes-between-functional-and-structural-brain-connectome-in-community-living-elders
#13
Yu Sun, Junhua Li, John Suckling, Lei Feng
Human brain is structurally and functionally asymmetrical and the asymmetries of brain phenotypes have been shown to change in normal aging. Recent advances in graph theoretical analysis have showed topological lateralization between hemispheric networks in the human brain throughout the lifespan. Nevertheless, apparent discrepancies of hemispheric asymmetry were reported between the structural and functional brain networks, indicating the potentially complex asymmetry patterns between structural and functional networks in aging population...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29208000/dynamics-behind-the-scale-up-of-evidence-based-obesity-prevention-protocol-for-a-multi-site-case-study-of-an-electronic-implementation-monitoring-system-in-health-promotion-practice
#14
Kathleen P Conte, Sisse Groen, Victoria Loblay, Amanda Green, Andrew Milat, Lina Persson, Christine Innes-Hughes, Jo Mitchell, Sarah Thackway, Mandy Williams, Penelope Hawe
BACKGROUND: The effectiveness of many interventions to promote health and prevent disease has been well established. The imperative has therefore shifted from amassing evidence about efficacy to scale-up to maximise population-level health gains. Electronic implementation monitoring, or 'e-monitoring', systems have been designed to assist and track the delivery of preventive policies and programs. However, there is little evidence on whether e-monitoring systems improve the dissemination, adoption, and ongoing delivery of evidence-based preventive programs...
December 6, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/29205692/changing-brain-connectivity-dynamics-from-early-childhood-to-adulthood
#15
Ashkan Faghiri, Julia M Stephen, Yu-Ping Wang, Tony W Wilson, Vince D Calhoun
Brain maturation through adolescence has been the topic of recent studies. Previous works have evaluated changes in morphometry and also changes in functional connectivity. However, most resting-state fMRI studies have focused on static connectivity. Here we examine the relationship between age/maturity and the dynamics of brain functional connectivity. Utilizing a resting fMRI dataset comprised 421 subjects ages 3-22 from the PING study, we first performed group ICA to extract independent components and their time courses...
December 5, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/29205574/different-pre-scanning-instructions-induce-distinct-psychological-and-resting-brain-states-during-functional-magnetic-resonance-imaging
#16
Toshikazu Kawagoe, Keiichi Onoda, Shuhei Yamaguchi
Resting-state functional magnetic resonance imaging (rs-fMRI) is widely used to investigate functional brain network connectivity during rest or when the subject is not performing an explicit task. In the standard procedure, subjects are instructed to "let your mind wander" or "think of nothing." While these instructions appear appropriate to induce a "resting-state," they could induce distinct psychological and physiological states during the scan. In this study, we investigated whether different instructions affect mental state and functional connectivity (FC) (i...
December 4, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29204807/analysis-of-fmri-data-using-noise-diffusion-network-models-a-new-covariance-coding-perspective
#17
Matthieu Gilson
Since the middle of the 1990s, studies of resting-state fMRI/BOLD data have explored the correlation patterns of activity across the whole brain, which is referred to as functional connectivity (FC). Among the many methods that have been developed to interpret FC, a recently proposed model-based approach describes the propagation of fluctuating BOLD activity within the recurrently connected brain network by inferring the effective connectivity (EC). In this model, EC quantifies the strengths of directional interactions between brain regions, viewed from the proxy of BOLD activity...
December 4, 2017: Biological Cybernetics
https://www.readbyqxmd.com/read/29204314/the-effect-of-botulinum-toxin-on-network-connectivity-in-cervical-dystonia-lessons-from-magnetoencephalography
#18
Abhimanyu Mahajan, Abdullah Alshammaa, Andrew Zillgitt, Susan M Bowyer, Peter LeWitt, Patricia Kaminski, Christos Sidiropoulos
Background: Pharmacological management of cervical dystonia (CD) is considered to be symptomatic in effect, rather than targeting the underlying pathophysiology of the disease. Magnetoencephalography (MEG), a direct measure of neuronal activity, while accepted as a modality for pre-surgical mapping in epilepsy, has never been used to explore the effect of pharmacotherapy in movement disorders. Methods: Resting state MEG data were collected from patients with CD, pre- and post-botulinum toxin injections...
2017: Tremor and Other Hyperkinetic Movements
https://www.readbyqxmd.com/read/29204113/effect-of-electro-acupuncture-and-moxibustion-on-brain-connectivity-in-patients-with-crohn-s-disease-a-resting-state-fmri-study
#19
Chunhui Bao, Di Wang, Peng Liu, Yin Shi, Xiaoming Jin, Luyi Wu, Xiaoqing Zeng, Jianye Zhang, Huirong Liu, Huangan Wu
Acupuncture and moxibustion have been shown to be effective in treating Crohn's disease (CD), but their therapeutic mechanisms remain unclear. Here we compared brain responses to either electro-acupuncture or moxibustion treatment in CD patients experiencing remission. A total of 65 patients were randomly divided into an electro-acupuncture group (n = 32) or a moxibustion group (n = 33), and treated for 12 weeks. Eighteen patients in the electro-acupuncture group and 20 patients in the moxibustion group underwent resting-state functional magnetic resonance imaging at baseline and after treatment...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29202110/aberrant-temporal-connectivity-in-persons-at-clinical-high-risk-for-psychosis
#20
Tiziano Colibazzi, Zhen Yang, Guillermo Horga, Yan Chao-Gan, Cheryl M Corcoran, Kristin Klahr, Gary Brucato, Ragy Girgis, Anissa Abi-Dargham, Michael P Milham, Bradley S Peterson
Background: Schizophrenia, a neurodevelopmental disorder, involves abnormalities in functional connectivity (FC) across distributed neural networks, which are thought to antedate the emergence of psychosis. In a cohort of adolescents and young adults at clinical high risk (CHR) for psychosis, we applied data-driven approaches to resting-state fMRI data so as to systematically characterize FC abnormalities during this period and determine whether these abnormalities are associated with psychosis risk and severity of psychotic symptoms...
November 2017: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
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