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https://www.readbyqxmd.com/read/29161763/quantifying-the-relationship-between-inhibition-of-vegfr-2-drug-induced-blood-pressure-elevation-and-hypertension
#1
Teresa Collins, Kelly Gray, Michal Bista, Matt Skinner, Christopher Hardy, Haiyun Wang, Jerome T Mettetal, Alexander R Harmer
BACKGROUND AND PURPOSE: Several anti-angiogenic cancer drugs that inhibit VEGF receptor (VEGFR) signalling for efficacy are associated with a 15-60% incidence of hypertension. Tyrosine kinase inhibitors (TKIs) that have off-target activity at VEGFR-2 may also cause blood pressure elevation as an undesirable side effect. Therefore, the ability to translate VEGFR-2 off-target potency into blood pressure elevation would be useful in development of novel TKIs. EXPERIMENTAL APPROACH: We sought to quantify the relationship between VEGFR-2 inhibition and blood pressure elevation for a range of kinase inhibitors...
November 21, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29161492/bionomics-of-anopheles-nyssorhynchus-albimanus-diptera-culicidae-in-two-villages-of-the-way%C3%A3%C2%BAu-people-riohacha-la-guajira-colombia
#2
Airleth Sofía Díaz, Aura Isabel Sotelo, Catalina González-Uribe, Helena L Brochero
INTRODUCTION: Riohacha, capital of the department of La Guajira, reports the highest rates for malaria in the department, and the most vulnerable people are those of the Wayúu indigenous group. OBJECTIVE: To describe some aspects of the bionomics of the Anopheles species in two Wayúu settlements. MATERIALS AND METHODS: Two sampling events were carried out during dry and rainy seasons in Marbacella and El Horno (Riohacha, La Guajira). Immature stages of Anopheles spp...
March 29, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/29161483/-spatio-temporal-analysis-of-the-biophysical-and-ecological-conditions-of-triatoma-dimidiata-hemiptera-reduviidae-triatominae-in-the-northeast-region-of-colombia
#3
Jaime Badel-Mogollón, Laura Rodríguez-Figueroa, Gabriel Parra-Henao
INTRODUCTION: Due to the lack of information regarding biophysical and spatio-temporal conditions (hydrometheorologic and vegetal coverage density) in areas with Triatoma dimidiata in the Colombian departments of Santander and Boyacá, there is a need to elucidate the association patterns of these variables to determine the distribution and control of this species. OBJECTIVE: To make a spatio-temporal analysis of biophysical variables related to the distribution of T...
March 29, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/29161469/validation-of-a-definition-for-flare-in-patients-with-established-gout
#4
Angelo L Gaffo, Nicola Dalbeth, Kenneth G Saag, Jasvinder A Singh, Elizabeth J Rahn, Amy S Mudano, Yi-Hsing Chen, Ching-Tsai Lin, Sandra Bourke, Worawit Louthrenoo, Janitzia Vazquez-Mellado, Hansel Hernández-Llinas, Tuhina Neogi, Ana Beatriz Vargas-Santos, Geraldo da Rocha Castelar-Pinheiro, Rodrigo B C Amorim, Till Uhlig, Hilde B Hammer, Maxim Eliseev, Fernando Perez-Ruiz, Lorenzo Cavagna, Geraldine M McCarthy, Lisa K Stamp, Martijn Gerritsen, Viktoria Fana, Francisca Sivera, William Taylor
OBJECTIVE: To perform external validation of provisional gout flare (attack) definitions in patients with gout. METHODS: We enrolled 509 participants with gout from 17 international sites in a cross-sectional study performed during routine clinical care and collected data to classify participants as experiencing a gout flare or not according to a provisional definition. A local expert rheumatologist performed the final independent adjudication of the gout flare status...
November 21, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29161273/enrichment-of-colorectal-cancer-associations-in-functional-regions-insight-for-using-epigenomics-data-in-the-analysis-of-whole-genome-sequence-imputed-gwas-data
#5
Stephanie A Bien, Paul L Auer, Tabitha A Harrison, Conghui Qu, Charles M Connolly, Peyton G Greenside, Sai Chen, Sonja I Berndt, Stéphane Bézieau, Hyun M Kang, Jeroen Huyghe, Hermann Brenner, Graham Casey, Andrew T Chan, John L Hopper, Barbara L Banbury, Jenny Chang-Claude, Stephen J Chanock, Robert W Haile, Michael Hoffmeister, Christian Fuchsberger, Mark A Jenkins, Suzanne M Leal, Mathieu Lemire, Polly A Newcomb, Steven Gallinger, John D Potter, Robert E Schoen, Martha L Slattery, Joshua D Smith, Loic Le Marchand, Emily White, Brent W Zanke, Goncalo R Abeçasis, Christopher S Carlson, Ulrike Peters, Deborah A Nickerson, Anshul Kundaje, Li Hsu
BACKGROUND: The evaluation of less frequent genetic variants and their effect on complex disease pose new challenges for genomic research. To investigate whether epigenetic data can be used to inform aggregate rare-variant association methods (RVAM), we assessed whether variants more significantly associated with colorectal cancer (CRC) were preferentially located in non-coding regulatory regions, and whether enrichment was specific to colorectal tissues. METHODS: Active regulatory elements (ARE) were mapped using data from 127 tissues and cell-types from NIH Roadmap Epigenomics and Encyclopedia of DNA Elements (ENCODE) projects...
2017: PloS One
https://www.readbyqxmd.com/read/29161212/positive-affect-as-a-predictor-of-smoking-cessation-and-relapse-does-it-offer-unique-predictive-value-among-depressive-symptom-domains
#6
Jaimee L Heffner, Kristin E Mull, Jennifer B McClure, Jonathan B Bricker
BACKGROUND: Prior studies have suggested that, among the domains of depressive symptoms, low positive affect (PA) may have a distinct relationship with smoking cessation and relapse. However, the empirical basis for PA-focused interventions cessation is limited, with some mixed findings. OBJECTIVES: Using a large, diverse sample of treatment-seeking smokers, this study tested the hypothesis that PA adds unique predictive value beyond the effects of the other symptom domains in models of cessation and relapse...
November 21, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/29161195/successful-aging-the-role-of-cognitive-gerontology
#7
Alan Hartley, Lucie Angel, Alan Castel, André Didierjean, Lisa Geraci, Joellen Hartley, Eliot Hazeltine, Patrick Lemaire, François Maquestiaux, Eric Ruthruff, Laurence Taconnat, Catherine Thevenot, Dayna Touron
This commentary explores the relationships between the construct of successful aging and the experimental psychology of human aging-cognitive gerontology. What can or should cognitive gerontology contribute to understanding, defining, and assessing successful aging? Standards for successful aging reflect value judgments that are culturally and historically situated. Fundamentally, they address social policy; they are prescriptive. If individuals or groups are deemed to be aging successfully, then their characteristics or situations can be emulated...
November 21, 2017: Experimental Aging Research
https://www.readbyqxmd.com/read/29161164/health-science-students-attitudes-towards-healthcare-teams-a-comparison-between-two-universities
#8
Takatoshi Makino, Bumsuk Lee, Hiroki Matsui, Yoshiharu Tokita, Hiromitsu Shinozaki, Shiomi Kanaizumi, Yumiko Abe, Takayuki Saitoh, Fusae Tozato, Ayako Igarashi, Mika Sato, Shigeki Ohtake, Noriko Tabuchi, Michiko Inagaki, Akinori Kama, Hideomi Watanabe
There have been few studies comparing the attitudes towards healthcare teams between different universities. This study analysed the differences in attitudes towards healthcare teams between health science students at Gunma University, Japan, which implements a comprehensive interprofessional education (IPE) programme, and Kanazawa University, a similar national university. Study populations were first- and third-year students at the Gunma University School of Health Sciences and the Kanazawa University School of Health Sciences...
November 21, 2017: Journal of Interprofessional Care
https://www.readbyqxmd.com/read/29161046/heavy-metal-free-tannin-from-bark-for-sustainable-energy-storage
#9
Alolika Mukhopadhyay, Yucong Jiao, Rui Katahira, Peter N Ciesielski, Michael E Himmel, Hongli Zhu
A novel renewable cathode made from earth-abundant, low-cost materials can contribute to the intermittent storage needs of renewable energy based society. Inspired by Nature, we report for the first-time tannin as a cathode material. Our approach exploits the charge storage mechanism of the redox active quinone moiety. Tannins extracted from tree bark using environmental friendly aqueous solvents has the highest phenol content (5.56 mol g-1) among all the natural phenolic biopolymers, 5000 times higher than lignin...
November 21, 2017: Nano Letters
https://www.readbyqxmd.com/read/29161024/performance-and-stability-enhancement-of-in-sn-zn-o-tfts-using-sio2-gate-dielectrics-grown-by-low-temperature-atomic-layer-deposition
#10
Jiazhen Sheng, Ju-Hwan Han, Wan-Ho Choi, Jozeph Park, Jin-Seong Park
Silicon dioxide (SiO2) films were synthesized by plasma enhanced atomic layer deposition (PEALD) using BTBAS (bis(tertiarybutylamino) silane) as the precursor and O2 plasma as the reactant, at a temperature range of 50 to 200 °C. While dielectric constant values larger than 3.7 are obtained at all deposition temperatures, the leakage current levels are drastically reduced to below 10-12 A at temperatures above 150 °C, which are similar to those obtained in thermally oxidized and PECVD grown SiO2. Thin film transistors (TFTs) based on In-Sn-Zn-O (ITZO) semiconductors were fabricated using thermal SiO2, PECVD SiO2 and PEALD SiO2 grown at 150 °C as the gate dielectrics, and superior device performance and stability are observed in the last case...
November 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29161011/the-design-of-plasmodium-vivax-hypoxanthine-guanine-phosphoribosyltransferase-inhibitors-as-potential-antimalarial-therapeutics
#11
Dianne T Keough, Dominik Rejman, Radek Pohl, Eva Zborníková, Dana Hockova, Tristan Croll, Michael D Edstein, Geoff W Birrell, Marina Chavchich, Lieve M J Naesens, Gregory K Pierens, Ian M Brereton, Luke W Guddat
Plasmodium falciparum (Pf) and Plasmodium vivax (Pv) are the foremost causative agents of malaria. Due to the development of resistance to current antimalarial medications, new drugs for this parasitic disease need to be discovered. The activity of hypoxanthine-guanine-[xanthine]-phosphoribosyltransferase, HG[X]PRT, is reported to be essential for the growth of both of these parasites, making it an excellent target for antimalarial drug discovery. Here, we have used rational structure-based methods to design an inhibitor, [3R,4R]-4-guanin-9-yl-3-((S)-2-hydroxy-2-phosphonoethyl)oxy-1-N-(phosphonopropionyl)pyrrolidine, of PvHGPRT and PfHGXPRT which has Ki values of 8 nM and 7 nM, respectively for these two enzymes...
November 21, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/29160958/prognostic-value-of-an-immunohistochemical-signature-in-patients-with-esophageal-squamous-cell-carcinoma-undergoing-radical-esophagectomy
#12
Jin Meng, Junhua Zhang, Yingjie Xiu, Yan Jin, Jiaqing Xiang, Yongzhan Nie, Shen Fu, Kuaile Zhao
Here, we aimed to identify an immunohistochemical (IHC)-based classifier as a prognostic factor in patients with esophageal squamous cell carcinoma (ESCC). A cohort of 235 patients with ESCC undergoing radical esophagectomy (with complete clinical and pathological information) were enrolled in the study. Using the least absolute shrinkage and selection operator (LASSO) regression model, we extracted six IHC features associated with progression-free survival (PFS) and then built a classifier in the discovery cohort (n=141)...
November 21, 2017: Molecular Oncology
https://www.readbyqxmd.com/read/29160929/anatomical-variations-of-the-human-cochlea-determined-from-micro-ct-and-high-resolution-ct-imaging-and-reconstruction
#13
Jie Tang, Xianglong Tang, Zhenhua Li, YiKang Liu, SongHua Tan, Heng Li, RongDan Ke, Zhi Wang, Li Gong, AnZhou Tang
Understanding the anatomical variations in the human cochlea are important for cochlear implants. This study examined these variations using a reconstructed fusion model of the skull and temporal bone. The 3D digital model of the temporal bone was reconstructed from multiple axial micro-CT scans of temporal bone and high resolution CT (HRCT) of the skull from 15 cadavers. A skull model was reconstructed and merged with the reconstructed temporal bone. The 3D relationship between the cochlea and the skull's mid-sagittal plane was analyzed...
November 21, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29160925/effects-of-swaddled-and-traditional-tub-bathing-methods-on-crying-and-physiological-responses-of-newborns
#14
Sinem Yalnızoğlu Çaka, Duygu Gözen
PURPOSE: The purpose of this study was to examine the effects of two bathing methods on crying duration and physiological measurements of newborns. DESIGN AND METHODS: A randomized trial design was used in this study. The sample consisted of newborns (n = 80) who were admitted to neonatal intensive care unit of a university hospital located in a large city. The groups were determined as swaddled bathing (SB) (n = 40) and traditional tub bathing (TTB) (n = 40) by using random number table...
November 21, 2017: Journal for Specialists in Pediatric Nursing: JSPN
https://www.readbyqxmd.com/read/29160923/pregnancy-weight-gain-by-gestational-age-and-stillbirth-a-population-based-cohort-study
#15
Kari Johansson, Jennifer A Hutcheon, Lisa M Bodnar, Sven Cnattingius, Olof Stephansson
OBJECTIVE: To study the association between total and early pregnancy (<22 completed weeks) weight gain and risk of stillbirth, stratified by early-pregnancy body mass index (BMI). DESIGN: Population-based cohort study. SETTING: Stockholm-Gotland Region, Sweden. POPULATION: Pregnant women with singleton births (n=160,560). METHODS: Pregnancy weight gain was standardized into gestational age-specific z-scores...
November 21, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29160907/inhibition-effects-of-flavonoids-on-2-amino-3-8-dimethyl-imidazo-4-5-f-quinoxaline-and-2-amino-3-7-8-trimethyl-imidazo-4-5-f-quinoxaline-formation-and-alkoxy-radical-scavenging-capabilities-of-flavonoids-in-a-model-system
#16
Zeping Shao, Zhonghui Han, Jinhui Zhang, Yan Zhang, Shuo Wang
BACKGROUND: Heterocyclic aromatic amines (HAAs) have been considered as carcinogenic and mutagenic chemicals generated during thermal processing of protein-rich foods which can be inhibited by some flavonoids. And free radical scavenging is a major characteristic of flavonoids. RESULTS: The half maximal inhibitory concentration (IC50 ) values of nine flavonoids were determined by evaluating their capacity to inhibit 2-amino-3,8-dimethyl-imidazo[4,5-f]-quinoxaline (MeIQx) and 2-amino-3,7,8-trimethyl-imidazo[4,5-f]-quinoxaline (7,8-DiMeIQx) formation in a model system...
November 21, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29160888/iron-iii-complexes-of-2-methyl-6-pyrimidin-2-yl-hydrazonomethyl-phenol-as-spin-crossover-molecular-materials
#17
Juan Yuan, Mei-Jiao Liu, Cai-Ming Liu, Hui-Zhong Kou
Four new mononuclear Fe(iii) complexes 1-4 of 2-methyl-6-(pyrimidin-2-yl-hydrazonomethyl)-phenol (H2L) have been synthesized and characterized by magnetic susceptibility measurements and single-crystal X-ray diffraction analysis. Complexes 1-3 are ionic compounds with the formula [Fe(HL)2]X·nsolvent (X = ClO4(-) (1), BF4(-) (2) and Cl(-) (3)), while complex 4 ([Fe(HL)(L)]) is neutral. The central Fe(iii) ion in complexes 1-4 is coordinated by four nitrogen and two oxygen atoms of two Schiff base ligands HL(-) or L(2-), and the coordination geometries of Fe(III) are all distorted octahedral...
November 21, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29160836/an-in-vitro-study-of-the-photodynamic-effectiveness-of-go-ag-nanocomposites-against-human-breast-cancer-cells
#18
Fozia Shaheen, Muhammad Hammad Aziz, Muhammad Fakhar-E-Alam, Muhammad Atif, Mahvish Fatima, Riaz Ahmad, Atif Hanif, Saqib Anwar, Fatima Zafar, Ghazanfar Abbas, Syed Mansoor Ali, Mukhtar Ahmed
Graphene-based materials have garnered significant attention because of their versatile bioapplications and extraordinary properties. Graphene oxide (GO) is an extremely oxidized form of graphene accompanied by the functional groups of oxygen on its surface. GO is an outstanding platform on which to pacify silver nanoparticles (Ag NPs), which gives rise to the graphene oxide-silver nanoparticle (GO-Ag) nanocomposite. In this experimental study, the toxicity of graphene oxide-silver (GO-Ag) nanocomposites was assessed in an in vitro human breast cancer model to optimize the parameters of photodynamic therapy...
November 21, 2017: Nanomaterials
https://www.readbyqxmd.com/read/29160716/-and-ecarlottones-uncommon-chalconoids-from-fissistigma-latifolium-with-pro-apoptotic-activity
#19
Charlotte Gény, Alma Abou Samra, Pascal Retailleau, Bogdan I Iorga, Hristo Nedev, Khalijah Awang, Fanny Roussi, Marc Litaudon, Vincent Dumontet
Four new compounds, (+)- and (-)-ecarlottone (1), (±)-fislatifolione (5), (±)-isofislatifolione (6), and (±)-fislatifolic acid (7), and the known desmethoxyyangonin (2), didymocarpin-A (3), and dehydrodidymocarpin-A (4) were isolated from the stem bark of Fissistigma latifolium, by means of bioassay-guided purification using an in vitro affinity displacement assay based on the modulation of Bcl-xL/Bak and Mcl-1/Bid interactions. The structures of the new compounds were elucidated by NMR spectroscopic data analysis, and the absolute configurations of compounds (+)-1 and (-)-1 were assigned by comparison of experimental and computed ECD spectra...
November 21, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/29160686/human-hair-keratin-for-biocompatible-flexible-and-transient-electronic-devices
#20
Jieun Ko, Luong Thi Hieun Nguyen, Abhijith Surendran, Bee Yi Tan, Kee Woei Ng, Wei Lin Leong
Biomaterials have been attracting attention as a useful building block for biocompatible and bioresorbable electronics due to its non-toxic property and solution processabillity. In this work, we report the integration of biocompatible keratin from human hair as dielectric layer for organic thin-film transistors (TFTs), with high performance, flexibility and transient property. The keratin dielectric layer exhibited a high capacitance value above 1.27 μF/cm2 at 20 Hz due to the formation of electrical double layer...
November 21, 2017: ACS Applied Materials & Interfaces
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