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https://www.readbyqxmd.com/read/29907503/real-time-management-of-incident-learning-reports-in-a-radiation-oncology-department
#1
REVIEW
Jean L Wright, Arti Parekh, Byung-Han Rhieu, Valentina Opris, Annette Souranis, Amanda Choflet, Akila N Viswanathan, Theodore L DeWeese, Todd McNutt, Stephanie A Terezakis
PURPOSE: The optimal approach to managing incident learning system (ILS) reports remains unclear. Here, we describe our experience with prospective coding of events reported to the ILS with comparisons of risk scores on the basis of event type and process map location. METHODS AND MATERIALS: Reported events were coded by type, origin, and method of discovery. Events were given a risk priority number (RPN) and near-miss risk index (NMRI) score. We compared workflow versus near-miss events with respect to origin and detection in the process map and by risk scores...
May 8, 2018: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29906579/outcomes-of-aggressive-surgical-resection-in-growth-hormone-secreting-pituitary-adenomas-with-cavernous-sinus-invasion
#2
Hun Ho Park, Eui Hyun Kim, Cheol Ryong Ku, Eun Jig Lee, Sun Ho Kim
OBJECTIVE: Cavernous sinus (CS) invasion is an unfavorable factor hindering remission of growth hormone (GH)-secreting pituitary adenomas. However, few data exist on aggressive surgical resection. The authors investigate the role of CS exploration for GH-secreting pituitary adenomas with CS invasion. METHODS: We classified 132 patients with GH-secreting pituitary adenomas invading CS into 4 groups. The patients underwent surgery using a microsurgical transsphenoidal approach (TSA) with assistance of an endoscope...
June 12, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29902609/minimally-invasive-surgical-treatment-for-vertebral-artery-compression-in-a-patient-with-one-sided-ponticulus-posticus-and-ponticulus-lateralis-a-case-report
#3
Victor Lukianchikov, Ivan Lvov, Andrey Grin, Anton Kordonskiy, Natalia Polunina, Vladimir Krylov
BACKGROUND: Kimmerle anomaly is characterised by ossification of the posterior atlanto-occipital membrane with formation of a complete or incomplete bony ridge in the area of the groove for the vertebral artery (VA) (ponticulus posticus, PP). In some cases, the bony ridge may also be formed at the level of the VA emerging from the transverse process of the С1 vertebra (ponticulus lateralis, PL). The simultaneous one-sided formation of PL and PP is very rare. There are no literature data concerning surgical treatment for compression of the VA due to PL...
June 11, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29898705/piloting-a-mental-health-training-programme-for-community-health-workers-in-south-africa-an-exploration-of-changes-in-knowledge-confidence-and-attitudes
#4
Goodman Sibeko, Peter D Milligan, Marinda Roelofse, Lezel Molefe, Deborah Jonker, Jonathan Ipser, Crick Lund, Dan J Stein
BACKGROUND: There is a shortage of trained mental health workers in spite of the significant contribution of psychiatric disorders to the global disease burden. Task shifting, through the delegation of health care tasks to less specialised health workers such as community health workers (CHWs), is a promising approach to address the human resource shortage. CHWs in the Western Cape province of South Africa provide comprehensive chronic support which includes that for mental illness, but have thus far not received standardized mental health training...
June 14, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29881152/bi-portal-arthroscopic-spinal-surgery-bass-with-30%C3%A2-arthroscopy-for-far-lateral-approach-of-l5-s1-technical-note
#5
Ju-Eun Kim, Dae-Jung Choi
Background context: Lumbar foraminal stenosis or extraforaminal stenosis is a common cause of spinal cord radiculopathy. Recently, several authors have introduced an endoscopy-based spinal surgery technique. Purpose: The study aimed to introduce far lateral approach of biportal arthroscopic technique using 30° arthroscopy for foraminal decompression of L5-S1. Study design: Technical note. Patient sample: 12 consecutive patients...
June 2018: Journal of Orthopaedics
https://www.readbyqxmd.com/read/29860637/discovery-of-a-novel-periodontal-disease-associated-bacterium
#6
Pedro J Torres, John Thompson, Jeffrey S McLean, Scott T Kelley, Anna Edlund
One of the world's most common infectious disease, periodontitis (PD), derives from largely uncharacterized communities of oral bacteria growing as biofilms (a.k.a. plaque) on teeth and gum surfaces in periodontal pockets. Bacteria associated with periodontal disease trigger inflammatory responses in immune cells, which in later stages of the disease cause loss of both soft and hard tissue structures supporting teeth. Thus far, only a handful of bacteria have been characterized as infectious agents of PD. Although deep sequencing technologies, such as whole community shotgun sequencing have the potential to capture a detailed picture of highly complex bacterial communities in any given environment, we still lack major reference genomes for the oral microbiome associated with PD and other diseases...
June 2, 2018: Microbial Ecology
https://www.readbyqxmd.com/read/29848814/evolution-in-the-surgical-management-of-hemorrhoidal-disease
#7
Angelo Guttadauro, Matteo Maternini, Marco Chiarelli, Giulia Lo Bianco, Nicoletta Pecora, Francesco Gabrielli
Hemorrhoidal disease is a very common condition requiring surgical management in approximately 10% of cases. Despite its long history and high prevalence, we are still trying to identify the best treatment. Earlier surgical approaches were soon abandoned and now only detain an historic significance. For long, proctologists have given their preference to hemorrhoidectomy that was gradually perfected through the years. The true innovation came in 1937, with the famous Milligan-Morgan hemorrhoidectomy, still one of the leading interventions for treatment of hemorrhoids...
2018: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29845013/the-anatomy-of-the-human-medial-forebrain-bundle-ventral-tegmental-area-connections-to-reward-associated-subcortical-and-frontal-lobe-regions
#8
Volker Arnd Coenen, Lena Valerie Schumacher, Christoph Kaller, Thomas Eduard Schlaepfer, Peter Christoph Reinacher, Karl Egger, Horst Urbach, Marco Reisert
Introduction: Despite their importance in reward, motivation, and learning there is only sparse anatomical knowledge about the human medial forebrain bundle (MFB) and the connectivity of the ventral tegmental area (VTA). A thorough anatomical and microstructural description of the reward related PFC/OFC regions and their connection to the VTA - the superolateral branch of the MFB (slMFB) - is however mandatory to enable an interpretation of distinct therapeutic effects from different interventional treatment modalities in neuropsychiatric disorders (DBS, TMS etc...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29801285/diffractive-shear-interferometry-for-extreme-ultraviolet-high-resolution-lensless-imaging
#9
G S M Jansen, A de Beurs, X Liu, K S E Eikema, S Witte
We demonstrate a novel imaging approach and associated reconstruction algorithm for far-field coherent diffractive imaging, based on the measurement of a pair of laterally sheared diffraction patterns. The differential phase profile retrieved from such a measurement leads to improved reconstruction accuracy, increased robustness against noise, and faster convergence compared to traditional coherent diffractive imaging methods. We measure laterally sheared diffraction patterns using Fourier-transform spectroscopy with two phase-locked pulse pairs from a high-harmonic source...
May 14, 2018: Optics Express
https://www.readbyqxmd.com/read/29799093/self-face-advantage-over-familiar-and-unfamiliar-faces-a-three-level-meta-analytic-approach
#10
REVIEW
Catherine Bortolon, Stéphane Raffard
Despite the increasing number of researchers interested in self-face, so far, no study has summarized the behavioral findings that contribute to the debate on self-face advantage. Most studies have focused on neural correlates of the self, although functional uniqueness can also be considered an important criterion for determining whether a stimulus is unique. The present meta-analysis systematically compared reaction time (RT) responses for self-face with other face identities across 54 studies. Different moderator factors were tested: familiarity, identity, head angle, laterality, and culture...
May 24, 2018: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/29782304/role-of-in-vivo-reflectance-confocal-microscopy-in-the-analysis-of-melanocytic-lesions
#11
Elena-Daniela Serban, Francesca Farnetani, Giovanni Pellacani, Maria Magdalena Constantin
Worldwide melanoma incidence and mortality are increasing (1). Despite the ongoing research, advanced melanoma is still incurable; therefore, the most appropriate solution seems to be early detection combined with complete surgical excision (2). Since the diagnostic protocol of suspicious lesions includes a complete excision with safety margins (2), the problem of unnecessary scarring is significant. The real challenge in this case is to have a properly formulated diagnosis before acquiring a biopsy. Currently available non-invasive techniques are coherence tomography, digital dermoscopy, and reflectance confocal microscopy...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29743358/the-chromatin-remodeling-factor-spoc1-acts-as-a-cellular-restriction-factor-against-human-cytomegalovirus-by-repressing-the-major-immediate-early-promoter
#12
Anna Reichel, Anne-Charlotte Stilp, Myriam Scherer, Nina Reuter, Sören Lukassen, Bahram Kasmapour, Sabrina Schreiner, Luka Cicin-Sain, Andreas Winterpacht, Thomas Stamminger
The cellular protein SPOC1 (survival time-associated PHD finger protein in ovarian cancer 1) acts as a regulator of chromatin structure and DNA damage response. It binds H3K4me2/3 containing chromatin and promotes DNA condensation by recruiting corepressors such as KAP-1 and H3K9 methyltransferases. Previous studies identified SPOC1 as a restriction factor against human adenovirus (HAdV) infection that is antagonized by E1B-55K/E4orf6-dependent proteasomal degradation. Here, we demonstrate that, in contrast to HAdV-infected cells, SPOC1 is transiently upregulated during the early phase of HCMV replication...
May 9, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29740508/case-presentation-and-short-perspective-on-management-of-foraminal-far-lateral-discs-and-stenosis
#13
REVIEW
Nancy E Epstein
Background: The management of lumbar foraminal/far lateral discs (FOR/FLD) with stenosis remains controversial. Operative choices should be based on each patient's preoperative dynamic X-ray findings, magnetic resonance (MR), and computed tomography (CT) studies. Here we reviewed several options for decompression alone vs. decompression with fusion. Methods: Safe excision of FOR/FLD with stenosis should begin at the level above the disc herniation, as identification of the superior, foraminally, and far laterally exiting nerve root is critical...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/29732989/towards-breast-cancer-vaccines-progress-and-challenges
#14
Javad Behravan, Atefeh Razazan, Ghazal Behravan
Breast cancer is the second leading cause of cancer death among women. National cancer institute of the US estimates that one in eight women will be diagnosed with breast cancer during their life time. Considering the devastating effects of the disease and the alarming numbers many scientists and research groups have devoted their research to fight breast cancer. Several recommendations are to be considered as preventing measures which include living a healthy life style, regular physical activity, weight control and, smoking cessation...
May 2, 2018: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29729008/analysis-of-the-far-medial-transoral-endoscopic-approach-to-the-infratemporal-fossa
#15
Hafiz S Patwa, Juan C Yanez-Siller, Matias Gomez Galarce, Bradley A Otto, Daniel M Prevedello, Ricardo L Carrau
OBJECTIVES/HYPOTHESIS: To demonstrate anatomic relationships of the far-medial transoral endoscopic assisted approach (FMT-EAA) to the infratemporal fossa (ITF) and define the corridor dimensions, surgical freedom, and limitations associated with this approach. STUDY DESIGN: Cadaveric study. METHODS: Twenty ITFs (10 specimens) were dissected with the assistance of 0 °, 30 °, and 45 ° rod-lens endoscopes. Image guidance was used to confirm and measure the corridors' structural boundaries and document the anatomical relationships encountered in this approach...
May 4, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29724156/pulp-regeneration-concepts-for-non-vital-teeth-from-tissue-engineering-to-clinical-approaches
#16
Valérie Orti, Pierre-Yves Collart-Dutilleul, Sofía Silvia Piglionico, Orsolya Pall, Frédéric Cuisinier, Ivan Vladislavov Panayotov
Following the basis of tissue engineering (Cells - Scaffold - Bioactive molecules), regenerative endodontic has emerged as a new concept of dental treatment. Clinical procedures have been proposed by endodontic practitioners willing to promote regenerative therapy. Preserving pulp vitality was a first approach. Later procedures aimed to regenerate a vascularized pulp in necrotic root canals. However, there is still no protocol allowing an effective regeneration of necrotic pulp tissue either in immature or mature teeth...
May 4, 2018: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/29704692/calcifying-pseudoneoplasm-of-the-neuraxis-capnon-in-the-lateral-cerebello-medullary-junction-clinical-image-with-surgical-video
#17
Halil Olgun Peker, Ilhan Aydin, Mustafa K Baskaya
Calcifying pseudoneoplasms of the neuraxis (CAPNON) are rare, benign and slow-growing lesions, which occur anywhere in the central nervous system without any age or sex predilection. The lesion's clinical course is variable and poorly understood because limited number of cases have been reported in the literature. In this report, we present a case of CAPNON in the lateral cerebello-medullary junction, which was removed via far-lateral approach. To best of our knowledge, this is the first report demonstrating actual lesion in a real-time surgical video, which may make the readers and viewers aware of such a pathology if they encounter this rare lesion...
April 25, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29685630/symptomatic-medulla-compression-by-vertebral-artery
#18
Leszek Lombarski, Przemysław Kunert, Marcin Skawiński, Marek Prokopienko, Zbigniew Lewandowski, Andrzej Marchel
OBJECTIVE: Vertebral artery medulla compression syndrome (VAMCS) is a very rare condition manifesting as different neurological focal deficits. The case of a 36-year-old male with symptomatic brainstem compression by vertebral artery (VA) treated by means of microvascular decompression (MVD) and a review of the literature is presented. CASE REPORT: On admission, a 36-year-old patient presented with hypoalgesia, hypothermesthesia and hemiparesis on the left side...
March 17, 2018: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/29683464/atomically-thin-p-n-junctions-based-on-two-dimensional-materials
#19
REVIEW
Riccardo Frisenda, Aday J Molina-Mendoza, Thomas Mueller, Andres Castellanos-Gomez, Herre S J van der Zant
Recent research in two-dimensional (2D) materials has boosted a renovated interest in the p-n junction, one of the oldest electrical components which can be used in electronics and optoelectronics. 2D materials offer remarkable flexibility to design novel p-n junction device architectures, not possible with conventional bulk semiconductors. In this Review we thoroughly describe the different 2D p-n junction geometries studied so far, focusing on vertical (out-of-plane) and lateral (in-plane) 2D junctions and on mixed-dimensional junctions...
May 8, 2018: Chemical Society Reviews
https://www.readbyqxmd.com/read/29662790/update-on-biomaterials-for-prevention-of-epidural-adhesion-after-lumbar-laminectomy
#20
REVIEW
Huailan Wang, Wenjia Sun, Dongliang Fu, Yueliang Shen, Ying-Ying Chen, Lin-Lin Wang
Lumbar laminectomy often results in failed back surgery syndrome. Most scholars support the three-dimensional theory of adhesion: Fibrosis surrounding the epidural tissues is based on the injured sacrospinalis behind, fibrous rings and posterior longitudinal ligaments. Approaches including using the minimally invasive technique, drugs, biomaterial and nonbiomaterial barriers to prevent the postoperative epidural adhesion were intensively investigated. Nevertheless, the results are far from satisfactory. Our review is based on various implant biomaterials that are used in clinical applications or are under study...
April 2018: Journal of Orthopaedic Translation
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