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https://www.readbyqxmd.com/read/28063269/novel-mapping-technique-for-localization-of-focal-and-reentrant-activation-during-atrial-fibrillation
#1
Yoshihide Takahashi, Shinsuke Iwai, Syu Yamashita, Mayumi Masumura, Masahito Suzuki, Kento Yabe, Yasuhiro Sato, Kenzo Hirao, Mitsuaki Isobe
INTRODUCTION: Identification of wavefront propagation pattern during AF remains challenging in ablation procedures. We sought to test a novel combination of a new mapping technology called Ripple Map and high density mapping to distinguish focal and reentrant activation during atrial fibrillation (AF). METHODS AND RESULTS: Subjects were patients undergoing ablation for persistent AF. If AF remained after isolation of the pulmonary veins, the left atrium (LA) was mapped by a high-density mapping catheter for later analysis, after which ablation was continued using a conventional stepwise approach...
January 7, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28060307/lateral-chronic-cranial-window-preparation-enables-in-vivo-observation-following-distal-middle-cerebral-artery-occlusion-in-mice
#2
Simon H Bayerl, Melina Nieminen-Kelhä, Thomas Broggini, Peter Vajkoczy, Vincent Prinz
Focal cerebral ischemia (i.e., ischemic stroke) may cause major brain injury, leading to a severe loss of neuronal function and consequently to a host of motor and cognitive disabilities. Its high prevalence poses a serious health burden, as stroke is among the principal causes of long-term disability and death worldwide(1). Recovery of neuronal function is, in most cases, only partial. So far, treatment options are very limited, in particular due to the narrow time window for thrombolysis(2,3). Determining methods to accelerate recovery from stroke remains a prime medical goal; however, this has been hampered by insufficient mechanistic insights into the recovery process...
December 29, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28043885/application-of-far-lateral-approach-to-sub-axial-spine-application-technical-difficulties-and-results
#3
Harnarayan Singh, Rana Patir, Sandeep Vaishya, Anurag Gupta, Rahul Miglani
No abstract text is available yet for this article.
December 30, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/28008833/-microbiotes-and-metagenomics
#4
Jean Weissenbach, Abdelghani Sghir
Major technical advances were introduced in the study of microflora and microbial communities in the nineties. These are essentially analytical approaches conducted as frequently by brute force. What conclusions can be drawn from these analyses twenty years later? In terms of microbial compositions, monitoring and diagnosis, the results are impressive. But what do all these microorganisms do? What are the factors behind their associations and their maintenance? Gene inventories are approaching completion; they allow us to deepen some physiological processes but do not say much more...
November 2016: Médecine Sciences: M/S
https://www.readbyqxmd.com/read/28005348/ultrahigh-vacuum-tip-enhanced-raman-spectroscopy
#5
Eric A Pozzi, Guillaume Goubert, Naihao Chiang, Nan Jiang, Craig T Chapman, Michael O McAnally, Anne-Isabelle Henry, Tamar Seideman, George C Schatz, Mark C Hersam, Richard P Van Duyne
Molecule-surface interactions and processes are at the heart of many technologies, including heterogeneous catalysis, organic photovoltaics, and nanoelectronics, yet they are rarely well understood at the molecular level. Given the inhomogeneous nature of surfaces, molecular properties often vary among individual surface sites, information that is lost in ensemble-averaged techniques. In order to access such site-resolved behavior, a technique must possess lateral resolution comparable to the size of surface sites under study, analytical power capable of examining chemical properties, and single-molecule sensitivity...
December 22, 2016: Chemical Reviews
https://www.readbyqxmd.com/read/27995452/an-optimal-approach-for-laparoscopic-d3-lymphadenectomy-plus-complete-mesocolic-excision-d3-cme-for-right-sided-colon-cancer
#6
Daxing Xie, Chaoran Yu, Chun Gao, Hasan Osaiweran, Junbo Hu, Jianping Gong
BACKGROUND: It is common knowledge that high ligation of blood vessels at the D3 level and complete mesocolic excision (CME) are two critical points of right hemicolectomy for right colon cancer (RCC). (1-5) To date, a safe strategy for completing these two procedures under laparoscopic surgery has not been extensively described. The authors provide a video to demonstrate laparoscopic right hemicolectomy (D3 + CME) with an optimal mesentery-defined approach. By identifying three "tri-junctions," this approach facilitates dissection of the entire mesocolon along the embryologic planes as far centrally as possible and enables the high tie of feeding vessels at bifurcation...
December 19, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27983596/estrogenic-endocrine-disrupting-chemicals-influencing-nrf1-regulated-gene-networks-in-the-development-of-complex-human-brain-diseases
#7
REVIEW
Mark Preciados, Changwon Yoo, Deodutta Roy
During the development of an individual from a single cell to prenatal stages to adolescence to adulthood and through the complete life span, humans are exposed to countless environmental and stochastic factors, including estrogenic endocrine disrupting chemicals. Brain cells and neural circuits are likely to be influenced by estrogenic endocrine disruptors (EEDs) because they strongly dependent on estrogens. In this review, we discuss both environmental, epidemiological, and experimental evidence on brain health with exposure to oral contraceptives, hormonal therapy, and EEDs such as bisphenol-A (BPA), polychlorinated biphenyls (PCBs), phthalates, and metalloestrogens, such as, arsenic, cadmium, and manganese...
December 13, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27982123/unraveling-gene-expression-profiles-in-peripheral-motor-nerve-from-amyotrophic-lateral-sclerosis-patients-insights-into-pathogenesis
#8
Nilo Riva, Ferdinando Clarelli, Teuta Domi, Federica Cerri, Francesca Gallia, Amelia Trimarco, Paola Brambilla, Christian Lunetta, Alberto Lazzerini, Giuseppe Lauria, Carla Taveggia, Sandro Iannaccone, Eduardo Nobile-Orazio, Giancarlo Comi, Maurizio D'Antonio, Filippo Martinelli-Boneschi, Angelo Quattrini
The aim of the present study is to investigate the molecular pathways underlying amyotrophic lateral sclerosis (ALS) pathogenesis within the peripheral nervous system. We analyzed gene expression changes in human motor nerve diagnostic biopsies obtained from eight ALS patients and seven patients affected by motor neuropathy as controls. An integrated transcriptomics and system biology approach was employed. We identified alterations in the expression of 815 genes, with 529 up-regulated and 286 down-regulated in ALS patients...
December 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27965073/outcomes-of-endonasal-and-lateral-approaches-to-petroclival-meningiomas
#9
Maria Koutourousiou, Juan C Fernandez-Miranda, Francisco Vaz Guimaraes Filho, John R de Almeida, Eric W Wang, Carl H Snyderman, Paul A Gardner
OBJECT: Transpetrosal approaches for the treatment of petroclival meningiomas are often associated with substantial morbidity and long recovery. With the goal of early clinical improvement, we have employed less invasive surgical approaches for petroclival meningiomas. METHODS: We retrospectively reviewed 32 patients with petroclival meningiomas. Eleven patients (34.4%) were managed with lateral approaches (retrosigmoid or far lateral approach), 17 (53.1%) with anterior midline approaches (endoscopic endonasal approach [EEA]) and 4 (12...
December 10, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27938934/medial-approach-of-ultrasound-guided-costoclavicular-plexus-block-and-its-effects-on-regional-perfussion
#10
D Nieuwveld, V Mojica, A E Herrera, J Pomés, A Prats, X Sala-Blanch
INTRODUCTION: Ultrasound-guided infraclavicular block in the costoclavicular space located between the clavicle and the first rib, reaches the secondary trunks when they are clustered together and lateral to the axillary artery. This block is most often performed through a lateral approach, the difficulty being finding the coracoid process an obstacle and guiding the needle towards the vessels and pleura. A medial approach, meaning from inside to outside, will avoid these structures. Traditionally the assessment of a successful block is through motor or sensitive responses but a sympathetic fibre block can also be evaluated measuring the changes in humeral artery blood flow, skin temperature and/or perfusion index...
December 8, 2016: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/27933249/an-enterogenous-cyst-with-atypical-pathological-findings-and-chemical-meningitis
#11
Lu Wang, Xiaona Chang, Chao Fu, Weidong Yu, Xiaoxuan Fang
INTRODUCTION: Intracranial enterogenous cysts are rare and mainly occur in the posterior fossa. These cysts are usually extra-axial, midline, anterior to the brainstem, or at the cerebellopontine angle. We report a case of an enterogenous cyst in which diagnosis was difficult because the lesion showed atypical pathologic findings. CASE PRESENTATION: A healthy 41-year-old man complained of paroxysmal occipital headaches lasting over a week, with increased severity for 3 days accompanied by slight dizziness and mild nausea...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27927190/cd4-cell-counts-and-presence-of-aids-in-hiv-positive-patients-entering-specialized-care-a-comparison-of-migrant-groups-in-the-german-clinsurv-hiv-cohort-study-1999-2013
#12
Nadine Zeitlmann, Barbara Gunsenheimer-Bartmeyer, Claudia Santos-Hövener, Christian Kollan, Matthias An der Heiden
BACKGROUND: Although early presentation to HIV-care is essential to ensure timely initiation of antiretroviral therapy, recent studies have shown that especially migrants present to HIV-care at a later stage of HIV-infection. Currently, thirty percent of all newly diagnosed HIV cases in Germany originate from abroad. So far it is unknown, which specific migrant groups in Germany are particularly at risk for late presentation to HIV-care. METHODS: We used data from the Clinical Surveillance of HIV Disease (ClinSurv) cohort, a multi-centre observational cohort (01/01/1999 and 31/07/2013) and included treatment-naïve patients with valid information on country of origin and date of enrolment...
December 7, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27923753/intra-and-extramedullary-dumbbell-shaped-schwannoma-of-the-medulla-oblongata-a%C3%A2-case-report-and-review-of-the-literature
#13
Qing Zhang, Ming Ni, Wei-Ming Liu, Wang Jia, Gui-Jun Jia, Jun-Ting Zhang
BACKGROUND: Brainstem intramedullary schwannomas (ISs) are extremely rare. Various theories have been suggested to explain its origin. It was first speculated that ISs arise from the region where the nerve roots lose their sheaths on penetrating the pia mater. Later, it was further predicted that ISs would contain both intra- and extramedullary parts and would be shaped like a dumbbell. However, no cases reported previously can support this assumption adequately. CASE DESCRIPTION: A 40-year-old woman presented with constant cervical pain, accompanied by progressive weakness of upper extremities and glove distribution numbness...
December 3, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27893844/the-florida-harvester-ant-pogonomyrmex-badius-relies-on-germination-to-consume-large-seeds
#14
Walter R Tschinkel, Christina L Kwapich
The Florida harvester ant, Pogonomyrmex badius, is one of many ant species and genera that stores large numbers of seeds in damp, underground chambers for later consumption. A comparison of the sizes of seeds recovered from storage chambers with those of seed husks discarded following consumption revealed that the used seeds are far smaller than stored seeds. This difference in use-rate was confirmed in field and laboratory colonies by offering marked seeds of various sizes and monitoring the appearance of size-specific chaff...
2016: PloS One
https://www.readbyqxmd.com/read/27892396/a-topography-of-free-kicks-in-soccer
#15
Daniel Link, Otto Kolbinger, Hendrik Weber, Michael Stöckl
This study investigates the spatial relationship of performance variables for soccer free kicks. In order to suggest ways in which players might optimise their performance, we collected data from free kicks (<35 m to goal line) of two German Bundesliga seasons (2013/14, 2014/15) (n = 1624). In the analysis, we applied the ISO-map approach using colour gradients to visualise the mean values of a variable on a 2D-map of the pitch. Additionally, variograms were used to describe the degree of spatial dependence of the free kick variables...
December 2016: Journal of Sports Sciences
https://www.readbyqxmd.com/read/27888345/robust-thalamic-nuclei-segmentation-method-based-on-local-diffusion-magnetic-resonance-properties
#16
Giovanni Battistella, Elena Najdenovska, Philippe Maeder, Naghmeh Ghazaleh, Alessandro Daducci, Jean-Philippe Thiran, Sébastien Jacquemont, Constantin Tuleasca, Marc Levivier, Meritxell Bach Cuadra, Eleonora Fornari
The thalamus is an essential relay station in the cortical-subcortical connections. It is characterized by a complex anatomical architecture composed of numerous small nuclei, which mediate the involvement of the thalamus in a wide range of neurological functions. We present a novel framework for segmenting the thalamic nuclei, which explores the orientation distribution functions (ODFs) from diffusion magnetic resonance images at 3 T. The differentiation of the complex intra-thalamic microstructure is improved by using the spherical harmonic (SH) representation of the ODFs, which provides full angular characterization of the diffusion process in each voxel...
November 25, 2016: Brain Structure & Function
https://www.readbyqxmd.com/read/27804261/a-dental-prosthesis-from-the-early-modern-age-in-tuscany-italy
#17
Simona Minozzi, Daniele Panetta, Massimo De Sanctis, Valentina Giuffra
BACKGROUND: During archaeological excavation, carried out in the S. Francesco Monastery at Lucca (Tuscany, Italy), a golden dental appliance was discovered. The prosthesis was found, together with commingled human remains, in the collective tomb of the aristocratic family of the Guinigi, a powerful family who governed Lucca from 1392 until 1429. The exact archaeological dating of the prosthesis was not possible, but some elements suggest a dating to the beginning of the 17th century. PURPOSE: Aim of the paper is to study and describe the dental appliance trough a multidisciplinary approach...
November 1, 2016: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/27778199/the-watson-forbes-biogeographical-controversy-untangled-170%C3%A2-years-later
#18
Simone Fattorini
Hewett Cottrell Watson and Edward Forbes were two naturalists of the Victorian age. They were protagonists on a dispute that generated comment and serves as an illuminating case study of misunderstanding in priority issues. Watson accused Forbes of having plagiarized his original classification of the British plants into groups on the basis of their geographical distribution. This controversy originated mostly from a so-far-ignored basic difference in Watson's and Forbes' ideas about biogeographical regionalization...
October 24, 2016: Journal of the History of Biology
https://www.readbyqxmd.com/read/27753836/sy-05-2-progression-of-hypertensive-heart-disease-new-therapeutic-approach
#19
Masatsugu Horiuchi
Hypertensive patients have greater chances of such cardiovascular events as stroke, coronary heart disease, heart or renal failure, peripheral artery disease, and dementia. It is also well recognized that diabetes increases the cardiovascular risks in concert with hypertension. Therefore, main goals for an innovation of anti-hypertensive therapy would be to achieve further risk reduction by targeting the functional, metabolic, and structural alterations associated with hypertension. Professors Dzau and Braunwald et al proposed the concept of "the cardiovascular disease continuum" in 1991, and that hypertension may trigger the chain of events, leading to end-stage heart disease; however, this concept was quite new at that time, and there was some discussion whether "the cardiovascular disease continuum" is true or not...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27743071/robotic-assisted-versus-laparoscopic-left-lateral-sectionectomy-analysis-of-surgical-outcomes-and-costs-by-a-propensity-score-matched-cohort-study
#20
Chady Salloum, Chetana Lim, Eylon Lahat, Concepcion Gomez I Gavara, Eric Levesque, Philippe Compagnon, Daniel Azoulay
BACKGROUND: After comparing with open approach, left lateral sectionectomy (LLS) has become standard in terms of short-term outcomes without jeopardizing long-term survival when performed for malignancy. The aim of this study was to compare the short-term and economic outcomes of laparoscopic (L-LLS) and robotic (R-LLS) LLS. METHODS: All consecutive patients who underwent L-LLS or R-LLS from 1997 to 2014 were analyzed. Short-term and economic outcomes were compared between the two groups using a propensity score matching (PSM)...
October 14, 2016: World Journal of Surgery
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