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https://www.readbyqxmd.com/read/28538069/normocephalic-pancraniosynostosis-a-report-of-a-surgical-technique
#1
Marcin Czerwinski, Sharon Monsivais
Normocephalic pancraniosynostosis is defined as the premature fusion of 3 or, more major sutures in the absence of another primary etiology, including primary, microcephaly, ventriculoperitoneal shunting, hypothyroidism, rickets, mucopolysaccharidoses, or other lysosomal storage diseases. It is very rare, thus far only 6 patients have been reported in the literature. Patients tend to present much later than those with single sutural, synostoses, and up to half have evidence of elevated intracranial pressure...
May 19, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28521360/exposure-of-the-external-carotid-artery-through-the-posterior-triangle-of-the-neck-a-novel-approach-to-facilitate-bypass-procedures-to-the-posterior-cerebral-circulation
#2
Ali Tayebi Meybodi, Michael T Lawton, Pooneh Mokhtari, Olivia Kola, Ivan H El-Sayed, Arnau Benet
BACKGROUND: The external carotid artery (ECA) is the main high-flow donor for extracranial-intracranial revascularization procedures. However, anatomic restraints limit the availability of ECA in posterior exposures of the craniocervical junction aimed for bypass to distal vertebral artery segments. OBJECTIVE: To examine the feasibility and safety of exposure of the ECA through the posterior triangle of the neck. METHODS: A preliminary feasibility study on the posterior neck exposure of the ECA was performed in 1 cadaveric head (2 sides) followed by a morphometric study on 9 cadaveric heads (18 sides)...
June 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28521347/sequential-extradural-release-of-the-v3-vertebral-artery-to-facilitate-intradural-v4-vertebral-artery-reanastomosis-feasibility-of-a-novel-revascularization-technique
#3
Ali Tayebi Meybodi, Michael T Lawton, Arnau Benet
BACKGROUND: Revascularization of the intradural vertebral artery (VA) usually involves V3-V4 bypass using an interposition graft. The interposition of a graft increases surgical time, adds risks, and requires 2 suture lines. OBJECTIVE: To assess the feasibility of an excision-reanastomosis of V4 by sequentially releasing V3. METHODS: Twenty specimens were prepared for surgical simulation of a far-lateral approach. The third and fourth segments of the VA were exposed through the far-lateral approach bilaterally...
June 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28516212/anatomical-visualization-of-neural-course-and-distribution-of-anterior-ascending-aortic-plexus
#4
Tomokazu Kawashima, Fumi Sato
The aim of this study was to document the detailed anatomy of neural course and distribution on the anterior ascending aorta, to identify the high and low density areas of the anterior ascending aortic plexus for further understandings in cardiovascular surgery. The embalmed hearts of 42 elderly individuals were submacroscopically and microscopically examined, after excluding any that were macroscopically abnormal. With its origins in the anterior ascending aortic plexus, the right coronary plexus substantially innervated the right coronary artery, the right atrium and ventricle, and the sinus node...
May 17, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28512043/endoscopic-assisted-supraorbital-keyhole-approach-or-endoscopic-endonasal-approach-in-case-of-tuberculum-sellae-meningioma-which-surgical-route-should-be-favoured
#5
Stefan Linsler, Gerrit Fischer, Volodymyr Skliarenko, Axel Stadie, Joachim Oertel
OBJECTIVE: Keyhole approaches are currently under investigation for skull base tumor surgery. They are expected to have a low complication rate with the same successful resection rate compared to endoscopic endonasal procedures. In this study, the authors compare their current series of tuberculum sellae meningiomas resected via an endoscopic endonasal or microsurgical supraorbital keyhole approach. METHODS: Between 2011 and 2016, 16 patients were treated using the supraorbital keyhole procedure and 6 patients received an endoscopic endonasal procedure...
May 13, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28508158/how-i-do-it-surgical-ligation-of-craniocervical-junction-dural-av-fistulas
#6
Thomas J Sorenson, Biagia La Pira, Joshua Hughes, Giuseppe Lanzino
BACKGROUND: Dural arteriovenous fistulas (DAVFs) of the craniocervical junction are uncommon vascular lesions, which often require surgical treatment even in the endovascular era. METHODS: Most commonly, the fistula is placed laterally, and surgical ligation is performed through a lateral suboccipital craniotomy. After dural opening, the area is inspected, and the arterialized vein is identified emerging from the dura, often adjacent to the entry point of the vertebral artery, and ligated...
May 15, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28463239/subcortical-brain-structure-and-suicidal-behaviour-in-major-depressive-disorder-a-meta-analysis-from-the-enigma-mdd-working-group
#7
M E Rentería, L Schmaal, D P Hibar, B Couvy-Duchesne, L T Strike, N T Mills, G I de Zubicaray, K L McMahon, S E Medland, N A Gillespie, S N Hatton, J Lagopoulos, D J Veltman, N van der Wee, T G M van Erp, K Wittfeld, H J Grabe, A Block, K Hegenscheid, H Völzke, I M Veer, H Walter, K Schnell, E Schramm, C Normann, D Schoepf, C Konrad, B Zurowski, B R Godlewska, P J Cowen, B W J H Penninx, N Jahanshad, P M Thompson, M J Wright, N G Martin, H Christensen, I B Hickie
The aetiology of suicidal behaviour is complex, and knowledge about its neurobiological mechanisms is limited. Neuroimaging methods provide a noninvasive approach to explore the neural correlates of suicide vulnerability in vivo. The ENIGMA-MDD Working Group is an international collaboration evaluating neuroimaging and clinical data from thousands of individuals collected by research groups from around the world. Here we present analyses in a subset sample (n=3097) for whom suicidality data were available. Prevalence of suicidal symptoms among major depressive disorder (MDD) cases ranged between 29 and 69% across cohorts...
May 2, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28458950/carotid-cavernous-fistula-after-percutaneous-balloon-compression-for-trigeminal-neuralgia-endovascular-treatment-with-coils
#8
Luana A M Gatto, Rafaella Tacla, Gelson L Koppe, Zeferino Demartini Junior
BACKGROUND: Percutaneous ganglyolysis treatment of trigeminal neuralgia is rarely associated with vascular complications, such as hematoma, subarachnoid hemorrhage, and stroke. Internal carotid artery injury may also occur after misguided needle placement, particularly far posteriorly or medially, resulting in carotid cavernous fistula. Anatomical variations of the foramen ovale can predispose those complications. CASE DESCRIPTION: A young woman diagnosed with trigeminal neuralgia during 11 years was submitted to a balloon rhizotomy by percutaneous approach to the trigeminal ganglion, with severe intraoperative bleeding...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28454192/-religious-spiritual-needs-and-psychosocial-burden-of-melanoma-patients
#9
Annette Haußmann, Norbert Schäffeler, Martin Hautzinger, Birgit Weyel, Thomas Eigentler, Stephan Zipfel, Martin Teufel
Questions of meaning and purpose in life are becoming relevant during cancer. Studies have shown that most patients have spiritual needs and that religion/spirituality can be an important ressource in coping with illness. So far, only few studies examine the psychosocial burden and the role of spiritual needs during the treatment process of patients with malignant melanoma. 22 patients were included in this study and assessed for psychosocial distress and spiritual needs while being screened for cancer metastases (t1) and 8 weeks later (t2)...
April 28, 2017: Psychotherapie, Psychosomatik, Medizinische Psychologie
https://www.readbyqxmd.com/read/28452613/fully-endoscopic-combined-transsphenoidal-and-supraorbital-keyhole-approach-for-parasellar-lesions
#10
Yuichi Nagata, Tadashi Watanabe, Tetsuya Nagatani, Kazuhito Takeuchi, Jonsu Chu, Toshihiko Wakabayashi
OBJECTIVE Parasellar tumors that extend far laterally beyond the internal carotid artery or that are fibrous and adhere firmly to critical structures are difficult to remove totally via the endoscopic transsphenoidal approach alone. In such cases, a combined transsphenoidal-transcranial approach is effective to achieve maximal resection in a single stage. In this paper, a new minimally invasive surgical technique for complicated parasellar lesions, a fully endoscopic combined transsphenoidal-supraorbital keyhole approach, is presented...
April 28, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28431568/a-case-report-of-severe-calciphylaxis-suggested-approach-for-diagnosis-and-treatment
#11
Margret Patecki, Gabriele Lehmann, Jan Hinrich Bräsen, Jessica Schmitz, Anna Bertram, Lars Daniel Berthold, Hermann Haller, Wilfried Gwinner
BACKGROUND: Calciphylaxis is a serious complication in patients with chronic kidney disease associated mineral and bone disorder. It can occur in conditions with low and high bone turnover. So far, there are no definite diagnostic and therapeutic guidelines which may prevent the devastating outcome in many calciphylaxis patients. We report a case which clearly illustrates that knowledge of the underlying bone disorder is essential for a directed treatment. Based on this experience we discuss a systematic diagnostic and therapeutic approach in patients with calciphylaxis...
April 21, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28415331/transition-radiation-at-the-boundary-of-a-chiral-isotropic-medium
#12
Sergey N Galyamin, Andrey V Tyukhtin, Anton A Peshkov
This study analyzes the radiation produced by a point charge intersecting the interface between a vacuum and a chiral isotropic medium. We deduce analytical expressions for the Fourier components of an electromagnetic field in both vacuum and medium for arbitrary charge velocity. The main focus is on investigating the far field in a vacuum. The distinguishing feature of the interface with a chiral isotropic medium is that the field in the vacuum area contains both copolarization (coinciding with the polarization of the self-field of a charge) and cross-polarization (orthogonal to the polarization of the self-field)...
March 2017: Physical Review. E
https://www.readbyqxmd.com/read/28402528/macrovascular-decompression-of-the-brainstem-and-cranial-nerves-evolution-of-an-anteromedial-vertebrobasilar-artery-transposition-technique
#13
Omar Choudhri, Ian D Connolly, Michael T Lawton
BACKGROUND: Tortuous and dolichoectatic vertebrobasilar arteries can impinge on the brainstem and cranial nerves to cause compression syndromes. Transposition techniques are often required to decompress the brainstem with dolichoectatic pathology. We describe our evolution of an anteromedial transposition technique and its efficacy in decompressing the brainstem and relieving symptoms. OBJECTIVE: To present the anteromedial vertebrobasilar artery transposition technique for macrovascular decompression of the brainstem and cranial nerves...
April 11, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28379577/new-research-perspectives-from-a-novel-approach-to-quantify-tracheid-wall-thickness
#14
Angela Luisa Prendin, Giai Petit, Marco Carrer, Patrick Fonti, Jesper Björklund, Georg von Arx
The analysis of xylem cell anatomical features in dated tree rings provides insights into xylem functional responses and past growth conditions at intra-annual resolution. So far, special focus has been given to the lumen of the water-conducting cells, whereas the equally relevant cell wall thickness (CWT) has been less investigated due to methodological limitations. Here we present a novel approach to measure tracheid CWT in high-resolution images of wood cross-sections that is implemented within the specialized image-analysis tool 'ROXAS'...
April 4, 2017: Tree Physiology
https://www.readbyqxmd.com/read/28379515/far-lateral-approach-without-drilling-the-occipital-condyle-for-vertebral-artery-posterior-inferior-cerebellar-artery-aneurysms
#15
Pablo Seoane, Samuel Kalb, Justin C Clark, Juan C Rivas, David S Xu, George A C Mendes, Mark C Preul, Joseph M Zabramski, Robert F Spetzler, Peter Nakaji
BACKGROUND: The far-lateral transcondylar surgical approach is often used to clip vertebral artery (VA) and posterior inferior cerebellar artery (PICA) aneurysms. The role of condyle resection during this approach is controversial. OBJECTIVE: To evaluate patient outcomes in patients with VA-PICA aneurysms in whom drilling the occipital condyle was not necessary. METHODS: Between May 2005 and December 2012, a total of 56 consecutive patients with incidental or ruptured VA-PICA aneurysms underwent surgery with a far-lateral approach without condylar resection...
April 4, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28362894/occipitocervical-instability-after-far-lateral-transcondylar-surgery-a-biomechanical-analysis
#16
Marcus D Mazur, William T Couldwell, Aaron Cutler, Lubdha M Shah, Darrel S Brodke, Kent Bachus, Andrew T Dailey
BACKGROUND: After a far-lateral transcondylar approach, patients may maintain neutral alignment in the immediate postoperative period, but severe occipitoatlantal subluxation may occur gradually with cranial settling and possible neurological injury. Previous research is based on assumptions regarding the extent of condylar resection and the change in biomechanics that produces instability. OBJECTIVE: To quantify the extent of bone removal during a far-lateral transcondylar approach, determine the changes in range of motion (ROM) and stiffness that occur after condylar resection, and identify the threshold of condylar resection that predicts alterations in occipitocervical biomechanics...
January 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28357160/mapping-the-internal-anatomy-of-the-lateral-brainstem-anatomical-study-with-application-to-far-lateral-approaches-to-intrinsic-brainstem-tumors
#17
Joe Iwanaga, Andre Granger, Payman Vahedi, Marios Loukas, Rod J Oskouian, Fabian N Fries, Iraj Lotfinia, Martin M Mortazavi, W Jerry Oakes, R Shane Tubbs
INTRODUCTION: Intramedullary brainstem tumors present a special challenge to the neurosurgeon. Unfortunately, there is no ideal part of the brainstem to incise for approaches to such pathology. Therefore, the present study was performed to identify what incisions on the lateral brainstem would result in the least amount of damage to eloquent tracts and nuclei. Case illustrations are also discussed. MATERIALS AND METHODS: Eight human brainstems were evaluated. Based on dissections and the use of standard atlases of brainstem anatomy, the most important deeper brainstem structures were mapped to the surface of the lateral brainstem...
February 3, 2017: Curēus
https://www.readbyqxmd.com/read/28342454/fate-of-micronuclei-and-micronucleated-cells
#18
REVIEW
Henning Hintzsche, Ulrike Hemmann, Albrecht Poth, Dietmar Utesch, Jasmin Lott, Helga Stopper
The present review describes available evidence about the fate of micronuclei and micronucleated cells. Micronuclei are small, extranuclear chromatin bodies surrounded by a nuclear envelope. The mechanisms underlying the formation of micronuclei are well understood but not much is known about the potential fate of micronuclei and micronucleated cells. Many studies with different experimental approaches addressed the various aspects of the post-mitotic fate of micronuclei and micronucleated cells. These studies are reviewed here considering four basic possibilities for potential fates of micronuclei: degradation of the micronucleus or the micronucleated cell, reincorporation into the main nucleus, extrusion from the cell, and persistence in the cytoplasm...
January 2017: Mutation Research
https://www.readbyqxmd.com/read/28338621/optimized-4-5-diarylimidazoles-as-potent-selective-inhibitors-of-protein-kinase-ck1%C3%AE-and-their-structural-relation-to-p38%C3%AE-mapk
#19
Jakob Halekotte, Lydia Witt, Chiara Ianes, Marc Krüger, Mike Bührmann, Daniel Rauh, Christian Pichlo, Elena Brunstein, Andreas Luxenburger, Ulrich Baumann, Uwe Knippschild, Joachim Bischof, Christian Peifer
The involvement of protein kinase CK1δ in the pathogenesis of severe disorders such as Alzheimer's disease, amyotrophic lateral sclerosis, familial advanced sleep phase syndrome, and cancer has dramatically increased interest in the development of effective small molecule inhibitors for both therapeutic application and basic research. Unfortunately, the design of CK1 isoform-specific compounds has proved to be highly complicated due to the existence of six evolutionarily conserved human CK1 members that possess similar, different, or even opposite physiological and pathophysiological implications...
March 24, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28323222/laparoscopic-nerve-preserving-sacropexy
#20
Alfredo Ercoli, Stefano Cosma, Francesca Riboni, Giuseppe Campagna, Paolo Petruzzelli, Daniela Surico, Saverio Danese, Giovanni Scambia, Chiara Benedetto
STUDY OBJECTIVE: to demonstrate our developed nerve preserving technique during laparoscopic sacropexy (LSP) for multicompartment pelvic organ prolapse. DESIGN: exemplificative case of our surgical procedure based on a multicentric experience consisting of more than 800 cases in 10 years without major intraoperative complications. Informed consent was taken from the subject, and the institutional review board approved this research. SETTING: public practice at Maggiore della Carità University Hospital, Novara; at Sant'Anna Hospital, City of Health and Science, University of Torino; at A...
March 17, 2017: Journal of Minimally Invasive Gynecology
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