Kim E Sapsford, Jessica Granek, Jeffrey R Deschamps, Kelly Boeneman, Juan Bautista Blanco-Canosa, Philip E Dawson, Kimihiro Susumu, Michael H Stewart, Igor L Medintz
Botulinum neurotoxins (BoNTs) are extremely potent bacterial toxins that contaminate food supplies along with having a high potential for exploitation as bioterrorism agents. There is a continuing need to rapidly and sensitively detect exposure to these toxins and to verify their active state, as the latter directly affects diagnosis and helps provide effective treatments. We investigate the use of semiconductor quantum dot (QD)-peptide Förster resonance energy transfer (FRET) assemblies to monitor the activity of the BoNT serotype A light chain protease (LcA)...
April 26, 2011: ACS Nano