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Botulinum toxin fo

Kim E Sapsford, Jessica Granek, Jeffrey R Deschamps, Kelly Boeneman, Juan Bautista Blanco-Canosa, Philip E Dawson, Kimihiro Susumu, Michael H Stewart, Igor L Medintz
Botulinum neurotoxins (BoNTs) are extremely potent bacterial toxins that contaminate food supplies along with having a high potential for exploitation as bioterrorism agents. There is a continuing need to rapidly and sensitively detect exposure to these toxins and to verify their active state, as the latter directly affects diagnosis and helps provide effective treatments. We investigate the use of semiconductor quantum dot (QD)-peptide Förster resonance energy transfer (FRET) assemblies to monitor the activity of the BoNT serotype A light chain protease (LcA)...
April 26, 2011: ACS Nano
Christopher Watts, Chad Nye, Renata Whurr
BACKGROUND: Spasmodic dysphonia is a neurological voice disorder characterized by involuntary adductor (towards midline) or abductor (away from midline) vocal fold spasms during phonation which result in phonatory breaks. Botulinum toxin is currently the gold standard of treatment. OBJECTIVE: To determine the efficacy of botulinum toxin therapy for the treatment of spasmodic dysphonia. DESIGN: Systematic Cochrane review. SEARCH STRATEGY: The search strategy for this review complied with Cochrane standards...
February 2006: Clinical Rehabilitation
C C W Watts, R Whurr, C Nye
BACKGROUND: The use of botulinum toxin for the treatment of spasmodic dysphonia is currently the treatment of choice for management of this neurological voice disorder. Over the past 20 years, botulinum toxin has been used to treat both adductor and abductor forms of the disorder, with vocal improvement noted after treatment for both. A large number of studies have attempted to document the efficacy of botulinum toxin for improvement of vocal symptoms in individuals with spasmodic dysphonia...
2004: Cochrane Database of Systematic Reviews
T Wehrmann, B Lembcke, M Jung
Endoscopic manometry and quantitative cholescintigraphy are the diagnostic cornerstones for the detection of suspected sphincter of Oddi dysfunction. In patients with recurrent biliary pain after cholecystectomy, endoscopic manometry proves an elevated sphincter of Oddi baseline pressure as the most common finding. The probability for the detection of an elevated baseline pressure in these patients is significantly correlated with the presence of certain clinical features (i.e. biliary pain and/or cholestasis and/or dilated bile duct and/or delayed drainage of contrast material after ERCP)...
December 1994: Zeitschrift Für Gastroenterologie
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