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seminal analysis

Minh P Lê, Marie-Laure Chaix, Sylvie Chevret, Julie Bertrand, François Raffi, Sébastien Gallien, El Mountacer Billah El Abbassi, Christine Katlama, Pierre Delobel, Yazdan Yazdanpanah, Juliette Saillard, Jean-Michel Molina, Gilles Peytavin
Background: In the ANRS 165 DARULIGHT study (NCT02384967) carried out in HIV-infected patients, the use of a darunavir/ritonavir-containing regimen with a switch to a reduced dose of darunavir maintained virological efficacy (≤50 copies/mL) for 48 weeks with a good safety profile. Objectives: To assess the total and unbound blood plasma pharmacokinetics of darunavir and associated antiretrovirals, and their penetration into semen before and after dose reduction...
June 13, 2018: Journal of Antimicrobial Chemotherapy
Deng'e Xie, Chen Lu, Ying Zhu, Sulan Zhu, Er-Jiang Yang, Xin Jin
We conducted this study to analyze the sperm DNA fragmentation index, conventional semen parameters, blood microelements and seminal plasma reactive oxygen species (ROS) in patients with male infertility to determine the association between each of the above male physiological parameters and DNA fragmentation index and infertility. Eighty cases of infertile males and 20 cases of normal males with children were divided into the infertility and control groups, respectively. Sperm DNA fragmentation index, conventional semen parameters, serum microelement content and seminal plasma ROS levels were detected, and the existing correlation between sperm DNA fragmentation index and the various physiological parameters were studied...
June 2018: Experimental and Therapeutic Medicine
Gerrit Glas
This paper gives an analysis of some conceptual issues in the neuroscientific study of empathy. The focus will almost exclusively be on a seminal paper by Decety and Jackson (2004) on the functional architecture of empathy. The authors withstand reductionistic tendencies in the exposition of what their findings might mean for the psychology of social cognition. They are aware of the thorny conceptual issues that arise when attempting to bridge intuitive folk psychological conceptions of empathy with explanations offered by social psychology, developmental science, and, most of all, neuroscience...
June 11, 2018: International Journal of Law and Psychiatry
Jean Fan, Hae-Ock Lee, Soohyun Lee, Da-Eun Ryu, Semin Lee, Catherine Xue, Seok Jin Kim, Kihyun Kim, Nikolas Barkas, Peter J Park, Woong-Yang Park, Peter V Kharchenko
Characterization of intratumoral heterogeneity is critical to cancer therapy, as presence of phenotypically diverse cell populations commonly fuels relapse and resistance to treatment. Although genetic variation is a well-studied source of intratumoral heterogeneity, the functional impact of most genetic alterations remains unclear. Even less understood is the relative importance of other factors influencing heterogeneity, such as epigenetic state or tumor microenvironment. To investigate the relationship between genetic and transcriptional heterogeneity in a context of cancer progression, we devised a computational approach called HoneyBADGER to identify copy number variation and loss-of-heterozygosity in individual cells from single-cell RNA-sequencing data...
June 13, 2018: Genome Research
Annalena Venneri, Caroline Jahn-Carta, Matteo De Marco, Davide Quaranta, Camillo Marra
Relatively spared during most of the timeline of normal aging, semantic memory shows a subtle yet measurable decline even during the pre-clinical stage of Alzheimer's disease. This decline is thought to reflect early neurofibrillary changes and impairment is detectable using tests of language relying on lexical-semantic abilities. A promising approach is the characterization of semantic parameters such as typicality and age of acquisition of words, and propositional density from verbal output. Seminal research like the Nun Study or the analysis of the linguistic decline of famous writers and politicians later diagnosed with Alzheimer's disease supports the early diagnostic value of semantic processing and semantic memory...
June 13, 2018: Biomarkers in Medicine
Nancy W Mikhael, Asmaa M El-Refaie, Jehan H Sabry, Essam M Akl, Amal Y Habashy, Taymour Mostafa
Varicocele has a common association with male infertility, but its exact role is still debated. Apoptosis has been suggested as one of the mechanisms of varicocele-associated infertility. Granulysin is a molecule that plays a role in apoptosis with no previous study about its role in male infertility. This case-controlled study aimed to assess seminal plasma granulysin level in infertile patients with varicocele. This study involved 90 men that were allocated into fertile normozoospermic men (n = 20), infertile men without varicocele (n = 30) and infertile men with varicocele (n = 40)...
June 13, 2018: Andrologia
Paulina López, Andrea Castro, Martha Flórez, Karen Miranda, Pilar Aranda, Cristina Sánchez-González, Juan Llopis, Miguel Arredondo
Obesity is characterized by mild chronic inflammation that is linked with impaired iron homeostasis. Studies in human and murine show that there is a transgenerational epigenetic inheritance via the gametes in obesity; however, there is little information on changes in the expression of microRNAs related to inflammation and iron homeostasis in spermatozoa from obese subjects. The present study investigated the expression of microRNAs related to inflammation (miR-21 y miR-155) and iron nutrition (miR-122 and miR-200b) in plasma, peripheral blood mononuclear cells (PBMC) and spermatozoa from normozoospermic controls (Cn; n = 17; BMI: 24...
2018: Frontiers in Genetics
Viviane Maria Codognoto, Paulo Henrique Yamada, Rúbia Alves Schmith, Felipe Rydygier de Ruediger, Caroline Scott, Patrícia de Faria Lainetti, Suzane Brochine, Camila de Paula Freitas-Dell'Aqua, Fabiana Ferreira de Souza, Eunice Oba
The objective of the present study was to describe the proteins from the seminal plasma of buffalo and correlate these proteins with sperm motility. Ejaculates from sixteen Murrah buffalo were used. Semen collection was performed by electroejaculation, and the ejaculate was evaluated by macroscopic (volume) and microscopic analysis (subjective motility and vigor, as well as sperm concentration). After the analysis, the samples were centrifuged (800g for 10 min and 10,000 for 30 min at 4 °C), and the supernatant (seminal plasma) was used to determine total protein concentration by the Bradford method...
June 2, 2018: Animal Reproduction Science
Matteo Tesi, Chiara Sabatini, Iacopo Vannozzi, Gloria Di Petta, Duccio Panzani, Francesco Camillo, Alessandra Rota
Although semen analysis is routinely used to evaluate the male reproductive potential in the canine species, only a few authors have attempted to relate semen characteristics to donor traits, such as age or weight, and fertility. This study evaluated the effects of dogs' age (young: 0-24 months, adult: 25-84 months, old: >84 months), size (small: <15 kg, medium: 16-40 kg, large: >40 kg) and reason for semen collection (evaluation, artificial insemination, cryopreservation or research purposes) on the seminal characteristics and related the main seminal characteristics with fresh AI results...
May 17, 2018: Theriogenology
Jessica M Johnston, Sheila E Francis, Endre Kiss-Toth
Background: Murine models of atherosclerosis have been invaluable to gain mechanistic understanding of this chronic disease. Induction of atherosclerosis with relative ease in ApoE-/- and Ldlr-/- mice fed a Western-type diet to cause hyperlipidaemia has provided researchers with popular tools to manipulate and characterise the action of genes that affect atherogenesis. Seminal studies and reviews have discussed key phenotypic differences between different models and "target levels of hyperlipidaemia" have also been published...
June 5, 2018: Cardiovascular Research
Alfonso Gomez-Iturriaga, Francisco Casquero, Jose Ignacio Pijoan, Juanita Crook, Arantza Urresola, Ana Ezquerro, Geert M Villeirs, Alberto Bossi, Jon Cacicedo, David Buchser, Pedro Bilbao
PURPOSE: To prospectively determine whether multiparametric magnetic resonance imaging (mpMRI)-based staging is a more accurate independent predictor of outcome than traditional clinical variables for patients undergoing brachytherapy and external beam radiation therapy. METHODS AND MATERIALS: The primary endpoints were biochemical (nadir plus 2 ng/mL) and metastatic failure. Descriptive, univariate, and multivariate competing risks analyses were performed. The cumulative incidence rates were estimated to describe the cumulative risk of the events of interest...
April 22, 2018: International Journal of Radiation Oncology, Biology, Physics
Alena Wiegandt, Henning N Behnken, Bernd Meyer
Prolactin-inducible protein (PIP) is a glycoprotein found in body secretions from exocrine glands like saliva and seminal plasma. Important biological functions of PIP concentrations have been demonstrated, e.g. in tumor diagnosis and progression. PIP quantity has been also found useful to determine the success of chemotherapy of mammary carcinoma. Here, we present the analysis of the N-glycosylation of PIP isolated from different sources by LC-MS(/MS) and 1 H-NMR. We found a very uncommon N-type glycosylation of PIP in healthy individuals from both, seminal fluid and saliva...
June 1, 2018: Glycoconjugate Journal
Chao Huang, Xiyue Cao, Dejiang Pang, Chao Li, Qihui Luo, Yuanfeng Zou, Bin Feng, Lixia Li, Anchun Cheng, Zhengli Chen
Objectives: We conducted a systematic review and meta-analysis of observational case-control studies to evaluate markers of oxidative stress in seminal plasma of patients with male infertility. Background: Current evidence links oxidative stress to male infertility, in which multiple markers of oxidative stress have been widely detected, publishing inconsistent results with regard to the role of oxidative stress markers in the evaluation of male infertility. Therefore, a systematic review and meta-analysis on this issue is necessary...
May 11, 2018: Oncotarget
Michael Weber, Julia Wunderer, Birgit Lengerer, Robert Pjeta, Marcelo Rodrigues, Lukas Schärer, Peter Ladurner, Steven A Ramm
BACKGROUND: Along with sperm, in many taxa ejaculates also contain large numbers of seminal fluid proteins (SFPs). SFPs and sperm are transferred to the mating partner, where they are thought to play key roles in mediating post-mating sexual selection. They modulate the partner's behavior and physiology in ways that influence the reproductive success of both partners, thus potentially leading to sexual conflict. Despite the presumed general functional and evolutionary significance of SFPs, their identification and characterization has to date focused on just a few animal groups, predominantly insects and mammals...
May 30, 2018: BMC Evolutionary Biology
Markus Janczyk, Veronika Lerche
Humans act goal-oriented, and this idea is at the core of ideomotor theory (IT), which claims that actions are selected by mentally anticipating the sensory consequences brought about by the respective bodily movement (i.e., their action effects). Evidence for this effect anticipation mainly derives from the response-effect (R-E) compatibility (REC) paradigm: In the spatial domain, for example, a left response is produced faster (and sometimes less error-prone) if followed by a compatible left rather than an incompatible right action effect...
May 31, 2018: Journal of Experimental Psychology. General
Mara Simopoulou, Anastassios Philippou, Evangelos Maziotis, Konstantinos Sfakianoudis, Nikolaos Nitsos, Panagiotis Bakas, Roxane Tenta, Evangelos Zevolis, Konstantinos Pantos, Michael Koutsilieris
Growth hormone (GH) and insulin-like growth factor 1 (IGF-1) have been proposed to play a pivotal role in male infertility due to their anabolic effects. The aim of this study was to investigate possible associations between seminal plasma levels of GH and IGF-1 and sperm parameters. Fifty men participated in this study. Semen analysis was performed, while cell-free seminal plasma was collected following sperm centrifugation. Seminal plasma concentrations of IGF-1 and GH were determined by enzyme-linked immunosorbent assay (ELISA)...
May 28, 2018: Andrologia
R Serafini, D D Varner, T L Blanchard, S R Teague, K LaCaze, C C Love
The tolerance of sperm DNA structure to seminal plasma and freezing conditions has both clinical and basic biologic relevance. In this study, fresh (FS) or flash-frozen (FZ) stallion epididymal sperm were exposed (SP+ ) or unexposed (SP- ) to seminal plasma. Sperm were then evaluated to monitor the degree of change in DNA structure following challenge with chemical (dithiothreitol-DTT), oxidative (iron sulfate; FeSO4 ) or enzymatic (DNase I) potentiators of DNA damage. For sperm not treated with potentiators (controls), there was no effect of SP treatment (SP- vs...
May 24, 2018: Theriogenology
Xu Liu, Yuling Jia, Liming Chong, Juan Jiang, Yang Yang, Lei Li, Aicui Ma, Zuyue Sun, Li Zhou
Cimetidine is widely used for the treatment of digestive tract ulcers, but it induces testis injury. To explore the mechanisms underlying cimetidine-induced toxicity towards the testis, the effects of oral cimetidine on the reproductive system of male rats were assessed. Cimetidine was orally administered to male rats at 20, 40 or 120 mg/kg/day for 9 weeks. The rats were then euthanized, and serum, testis, epididymis, prostate gland, seminal vesicle, preputial gland, levator ani muscle and sphincter ani samples were collected...
June 2018: Experimental and Therapeutic Medicine
Evan Kovac, Emily A Vertosick, Daniel D Sjoberg, Andrew J Vickers, Andrew J Stephenson
OBJECTIVES: To determine if the presence of adverse pathologic features in patients eligible for active surveillance are prognostic of poor oncologic outcomes, independent of pretreatment risk. PATIENTS & METHODS: A retrospective analysis was performed on patients who underwent radical prostatectomy at two institutions (CCF, MSKCC) between 1987-2008 and who had subsequent follow-up. Rates of biochemical recurrence, metastasis and death from prostate cancer were compared among patients with adverse pathologic features (Gleason ≥7, ≥pT3, or lymph node invasion) based on D'Amico clinical risk (low vs...
May 26, 2018: BJU International
Jun Huang, Zhouping Cheng, Ronggang Li, Nan Yao, Jiazheng Cao, Shuo Deng, Ronghai Wu
Schwannomas rarely occur in seminal vesicles. Here, we report a schwannoma of the left seminal vesicle. A 55-year-old man presented no clinical symptoms, and a mass in the left region of the seminal vesicle was found incidentally in a medical examination. A computed tomography and magnetic resonance imaging of pelvic were obtained and revealed a 5.17 × 2.59 × 3.5 cm mass on the left seminal vesicle. Transrectal ultrasound-guided seminal biopsy revealed a diagnosis of seminal vesical schwannoma. Laparoscopic resection of the tumour was performed...
May 24, 2018: Andrologia
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