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https://www.readbyqxmd.com/read/28315388/mechano-devo
#1
REVIEW
Olivier Hamant
In "On growth and form", D'Arcy Wentworth Thompson (1917) stresses the inevitable interactions between physics and developmental biology. With the recent progress in molecular genetics, live imaging, micromechanics and modeling, the study of morphogenesis has been rejuvenated in the present century: the activity of developmental genes can be interpreted in terms of mechanical properties to dissect the chain of events behind shape changes; in turn, patterns of shape- and growth-derived mechanical stress are calculated and shown to act as signals controlling cell effectors, in synergy with biochemical cues, thereby channeling morphogenesis...
March 15, 2017: Mechanisms of Development
https://www.readbyqxmd.com/read/28314792/comparative-profiling-of-small-rnas-of-pig-seminal-plasma-and-ejaculated-and-epididymal-sperm
#2
Cai Chen, Han Wu, Dan Shen, Saisai Wang, Li Zhang, Xiaoyan Wang, Bo Gao, Tianwen Wu, Bichun Li, Kui Li, Chengyi Song
The similarities and differences of small RNAs in seminal plasma, epididymal sperm and ejaculated sperm remain largely undefined. We conducted a systematic comparative analysis of small RNA profiles in pig ejaculated sperm, epididymal sperm and seminal plasma and found that the diversity distribution of small RNA species was generally similar, whereas the abundance of small RNAs is dramatically different across the three libraries; miRNAs and small RNAs derived from rRNA, tRNA, small nuclear RNA, 7SK RNA, NRON RNA and cis-regulatory RNA were enriched in the three libraries, but piRNA was absent...
March 17, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28314317/statins-protect-against-acute-rt-related-rectal-toxicity-in-patients-with-prostate-cancer-an-observational-prospective-study
#3
Isabella Palumbo, Fabio Matrone, Giampaolo Montesi, Rita Bellavita, Marco Lupattelli, Simonetta Saldi, Alessandro Frattegiani, Eleonora Arena, Cristina Mariucci, Lorenzo Falcinelli, Vittorio Bini, Cynthia Aristei
AIM: To analyze risk factors for acute rectal toxicity during hypofractionated intensity-modulated radiotherapy (IMRT) for prostate cancer. PATIENTS AND METHODS: A total of 195 patients received 74.25 Gy in 33 fractions to the prostate and, if involved, to the seminal vescicles (SV). When the risk of SV involvement was >15% according to the Roach's formula, they received 62 Gy in 33 fractions. Overall, 107/195 patients (54.87%) received hormonal therapy (luteinizing hormone-releasing hormone analogue, anti-androgen, or both)...
March 2017: Anticancer Research
https://www.readbyqxmd.com/read/28299752/therapeutic-implications-of-molecular-subtyping-for-pancreatic-cancer
#4
REVIEW
Michael J Pishvaian, Jonathan R Brody
The prognosis of metastatic pancreatic adenocarcinoma has recently begun to improve. In the last several years, first-line therapy with gemcitabine plus nab-paclitaxel or a regimen of fluorouracil, leucovorin, irinotecan, and oxaliplatin (FOLFIRINOX) has boosted the median overall survival (OS) duration to 8.5 months and 11 months, respectively, in patients with metastatic pancreatic cancer, compared with a historic OS of only 6 months prior to 2011. Moreover, sequencing these two regimens improved median OS to an unprecedented 18 months...
March 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/28296340/lactadherin-is-a-candidate-oviduct-lewis-x-trisaccharide-receptor-on-porcine-spermatozoa
#5
E Silva, D Frost, L Li, N Bovin, D J Miller
A recent study has demonstrated that porcine spermatozoa recognize with high affinity carbohydrate structures containing Lewis X motifs. Sperm adhesion to Lewis X is proposed to mediate sperm binding to the oviduct epithelium to form a reservoir. The objective of this study was to identify Lewis X-binding proteins from porcine spermatozoa as candidate receptors for oviduct glycans. To identify low-abundance proteins typically masked by proteins originating from seminal fluid, Lewis X candidate receptors were enriched from cauda epididymal boar spermatozoa...
March 15, 2017: Andrology
https://www.readbyqxmd.com/read/28296285/elevated-seminal-plasma-myeloperoxidase-is-associated-with-a-decreased-sperm-concentration-in-young-men
#6
J M Pullar, A C Carr, S M Bozonet, P Rosengrave, A J Kettle, M C M Vissers
Myeloperoxidase is a major neutrophil protein which generates oxidants that are highly reactive, and if present in seminal fluid, could be potentially damaging to spermatozoa. We recruited young males aged 18-35 years, unscreened for fertility status, for a pilot study measuring seminal plasma myeloperoxidase. On three occasions, over a 3-month period, we measured parameters of semen quality and correlated these with seminal myeloperoxidase protein and activity. After baseline measurement, participants were supplemented daily with 250 mg of vitamin C, a potent scavenger of reactive oxygen species with antiinflammatory activities...
March 10, 2017: Andrology
https://www.readbyqxmd.com/read/28290096/the-value-and-evaluability-of-the-pca3-urine-assay-in-prostate-carcinoma-is-independent-of-the-tumor-localization
#7
Eva Neumann, Jörg Hennenlotter, Tilman Todenhöfer, Marcus Scharpf, Tim Neumann, David Schilling, Arnulf Stenzl, Jens Bedke
INTRODUCTION: The prostate cancer gene 3 (PCA3) test is based on the analysis of tumor cell mRNA in urine. As an exprimated urinary marker, its retrieval is subject to certain physical aspects like palpation pressure and detachment force during the squeezing of cells. Other potential factor of influence may be the distance the cells have to cover until they reach the urethra. Thus, it was investigated whether the localization of the tumors within the prostate with regard to the urethra and the seminal colliculus influences the PCA3 score...
March 13, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28282967/first-record-of-gregarines-apicomplexa-in-seminal-vesicle-of-insect
#8
Glenda Dias, Romano Dallai, Antonio Carapelli, João P P Almeida, Lucio A O Campos, Leda R A Faroni, José Lino-Neto
Gregarines (Apicomplexa) are a diverse group of protozoan parasites, which infects gut and other body cavities of invertebrate hosts. In reproductive system of insects, gregarine has been reported only in the accessory glands and spermathecae of females; therefore, this is the first report of a gregarine species in seminal vesicles of insects. Different developmental stages, including sporozoytes, oocysts and trophozoites were described from morphological descriptions using light and electron transmission microscopy...
December 2017: Scientific Reports
https://www.readbyqxmd.com/read/28281040/the-effect-of-rapid-access-prostate-clinics-on-the-outcomes-of-gleason-7-prostate-cancer-does-earlier-diagnosis-lead-to-better-outcomes
#9
M P Broe, J C Forde, M S Inder, D J Galvin, D W Mulvin, D M Quinlan
INTRODUCTION: Rapid Access Prostate Clinics (RAPC) were introduced in Ireland by the National Cancer Control Programme bringing about expedited referral pathways and increased detection rates of prostate cancer. Lower Gleason (G) grade at diagnosis due to RAPC has been previously reported but grade at prostatectomy has not been assessed. The aim of this study was to assess the impact of RAPC on the outcomes of patients with G7 disease on radical prostatectomy (RP). METHODS: A retrospective analysis was carried out of all RPs performed over a 9-year period (2006-2014)...
March 9, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28274591/relationships-between-seminal-plasma-metals-metalloids-and-semen-quality-sperm-apoptosis-and-dna-integrity
#10
Yi-Xin Wang, Peng Wang, Wei Feng, Chong Liu, Pan Yang, Ying-Jun Chen, Li Sun, Yang Sun, Jing Yue, Long-Jie Gu, Qiang Zeng, Wen-Qing Lu
This study aimed to investigate the relationships between environmental exposure to metals/metalloids and semen quality, sperm apoptosis and DNA integrity using the metal/metalloids levels in seminal plasma as biomarkers. We determined 18 metals/metalloids in seminal plasma using an inductively coupled plasma-mass spectrometry among 746 men recruited from a reproductive medicine center. Associations of these metals/metalloids with semen quality (n = 746), sperm apoptosis (n = 331) and DNA integrity (n = 404) were evaluated using multivariate linear and logistic regression models...
March 5, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28274309/-purification-of-human-goose-type-lysozyme-2-hlysg2-from-human-seminal-plasma-and-analysis-of-its-enzymatic-properties
#11
Peng Huang, Zhifang Yang, Jianying Bao, Ning Zhang, Wenshu Li
Objective To purify human goose-type lysozyme 2 (HLysG2) from human seminal plasma by chromatography and analyze its enzymatic properties. Methods The distribution of HLysG2 in semen was analyzed by Western blot analysis. Seminal plasma was subjected to the separation of target protein using cation-exchange chromatography, chitin affinity chromatography and size-exclusion chromatography. The purified product was identified by Western blot analysis and mass spectrometry (MS).The purity was analyzed by high performance liquid chromatography (HPLC)...
March 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/28271215/moderate-hypofractionated-radiotherapy-with-volumetric-modulated-arc-therapy-and-simultaneous-integrated-boost-for-pelvic-irradiation-in-prostate-cancer
#12
C Franzese, A Fogliata, G R D'Agostino, L Di Brina, T Comito, P Navarria, L Cozzi, M Scorsetti
PURPOSE: The optimal treatment for unfavourable intermediate/high-risk prostate cancer is still debated. In the present study, the pattern of toxicity and early clinical outcome of patients with localized prostate cancer was analyzed. METHODS: A cohort of 90 patients treated on pelvic lymph nodes from 2010 to 2015 was selected. All patients were treated with Volumetric Modulated Arc Therapy (VMAT), and Simultaneous integrated boost (SIB) in 28 fractions; the prostate, the seminal vesicle and the pelvic lymph node received total doses of 74...
March 8, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28269037/robust-extraction-of-the-n1-effect-in-dichotic-listening-using-hardy-space-mappings-of-auditory-late-single-trials
#13
Farah I Corona-Strauss, Daniel J Strauss
It is known that signs of (early) auditory selective attention are reflected in the N1-wave of auditory late potentials. In recent years, we have analyzed this N1-effect using multiscale neurofunctional modeling and (instantaneous) phase synchronization measures of Hardy space mapped data. To acquire the electroencephalographic data in dichotic listening, we repeated the seminal experiment of Hillyard et al. which first described the N1-effect. Here we apply for the first time phase synchronization measures to these dichotic data and compare the results to the conventional time-domain analysis...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28266817/antioxidant-enzyme-profile-and-lipid-peroxidation-products-in-semen-samples-of-testicular-germ-cell-tumor-patients-submitted-to-orchiectomy
#14
Camila Sposito, Mariana Camargo, Danielle Spinola Tibaldi, Valéria Barradas, Agnaldo Pereira Cedenho, Marcílio Nichi, Ricardo Pimenta Bertolla, Deborah Montagnini Spaine
PURPOSE: To determine enzymatic antioxidant and lipid peroxidation levels in seminal plasma of patients orchiectomized for testicular tumors. MATERIALS AND METHODS: The study included 52 patients: 26 control men and 26 orchiectomized patients for testicular tumor, of which 12 men had seminoma tumor and 14 men non-seminoma tumor. After semen analysis performed according to the WHO guidelines, an aliquot of semen was centrifuged and the seminal plasma was collected...
March 7, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28264730/seminal-cell-free-dna-levels-measured-by-picogreen-fluorochrome-are-associated-with-sperm-fertility-criteria
#15
F Costa, F Barbisan, C E Assmann, N K F Araújo, A R de Oliveira, J P Signori, F Rogalski, B Bonadiman, M S Fernandes, I B M da Cruz
Previous investigations suggested that elevated cell-free DNA (cfDNA) can indicate non-healthy states. However, the potential association between cfDNA seminal plasma levels and fertility sperm parameters has not yet been determined. Therefore, the present study evaluated the association between seminal cfDNA levels and sperm fertility criteria to determine the use of seminal cfDNA quantification. An in vivo protocol quantified cfDNA levels of semen samples obtained from 163 male patients using fluorescent PicoGreen dye staining...
March 7, 2017: Zygote: the Biology of Gametes and Early Embryos
https://www.readbyqxmd.com/read/28258721/cancer-genomics-guide-clinical-practice-in-personalized-medicine
#16
Jacqueline Lehmann-Che, Brigitte Poirot, Jean-Christophe Boyer, Alexandre Evrard
Targeted therapy has revolutionized the treatment of many cancers. Widely developed over the last decade, this new concept of precision medicine relies on the use of genomic technologies to analyze tumor samples in order to identify actionable targets and biomarkers of resistance. The goal is to optimize treatment by identifying which therapeutic approach is best for each patient, i.e. the treatment that is effective, has minimal adverse effects, and avoids unnecessary intervention and cost. The purpose of this review is to highlight, using a few seminal examples of therapeutic targets, the important contribution of appropriate analysis of key oncogenes or driver genes makes to clinical decision-making...
January 30, 2017: Thérapie
https://www.readbyqxmd.com/read/28250713/identification-and-visualization-of-the-intellectual-structure-and-the-main-research-lines-in-nanoscience-and-nanotechnology-at-the-worldwide-level
#17
Teresa Muñoz-Écija, Benjamín Vargas-Quesada, Zaida Chinchilla-Rodríguez
The aim of this paper is to make manifest the intellectual and cognitive structure of nanoscience and nanotechnology (NST) by means of visualization techniques. To this end, we used data from the Web of Science (WoS), delimiting the data to the category NST during the period of 2000-2013, retrieving a total of 198,275 documents. Through direct author citation of these works, we identified their origins and the seminal papers, and through word co-occurrence extracted from the titles and abstracts, the main lines of research were identified...
2017: Journal of Nanoparticle Research: An Interdisciplinary Forum for Nanoscale Science and Technology
https://www.readbyqxmd.com/read/28247736/-cancer-and-genitourinary-tuberculosis-literature-review-and-clinical-observations
#18
D P Kholtobin, D P Kulchavenya, B T Khomyakov
Tuberculosis has been regarded as a counter-regulatory process to cancer. The development of tumors in the kidney that is affected by tuberculosis is considered as extremely rare, almost impossible case. The analysis of the literature on combined/sequential damage of urogenital organs by tuberculosis and cancer, and own clinical observation were performed. The case history of 72-year-old patient who sought medical advice for violation of urination is described. Previously he suffered from tuberculosis of the lungs and prostate cancer, and he was healed...
August 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28241900/expression-of-protocadherin-11yb-pcdh11yb-in-seminal-germ-cells-is-correlated-with-fertility-status-in-men
#19
Thottathil R Anilkumar, Anandavalli N Devi, Sathy M Pillai, Krishnapillai Jayakrishnan, Oommen V Oommen, Pradeep G Kumar
Protocadherin 11 Y-linked (PCDH11Y), a member of the cadherin superfamily, is predominantly expressed in the central nervous system, is encoded by the Yp11.2 locus and exists in three isoforms: 11Ya, 11Yb and 11Yc. PCDH11Y is upregulated by retinoic acid signalling and is essential for spermatogonial differentiation and initiation of meiosis. PCDH11Y mediates Wnt signalling, which plays a crucial role in the differentiation of various cell types. PCDH11Y has been implicated in neuronal cell differentiation and proliferation, but its association with spermatogenesis has not yet been addressed...
February 28, 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/28237197/toward-a-broader-concept-of-value-identifying-and-defining-elements-for-an-expanded-cost-effectiveness-analysis
#20
Louis P Garrison, Sachin Kamal-Bahl, Adrian Towse
This commentary identifies and defines potentially useful expansions to traditional cost-effectiveness analysis as often used in health technology assessment. Since the seminal 1977 article by Weinstein and Stason, the recommended approach has been the use of the incremental cost-effectiveness ratio based on the metric of the cost per quality-adjusted life-year gained, allowing comparisons across different technologies. An expanded framework, incorporating a wider range of the elements of value, is proposed...
February 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
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