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Environmental medicine

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https://www.readbyqxmd.com/read/28523173/thrombotic-responses-to-coronary-stents-bioresorbable-scaffolds-and-the-kounis-hypersensitivity-associated-acute-thrombotic-syndrome
#1
REVIEW
Nicholas G Kounis, Ioanna Koniari, Anastasios Roumeliotis, Grigorios Tsigas, George Soufras, Nicholas Grapsas, Periklis Davlouros, George Hahalis
Percutaneous transluminal coronary angioplasty with coronary stent implantation is a life-saving medical procedure that has become, nowadays, the most frequent performed therapeutic procedure in medicine. Plain balloon angioplasty, bare metal stents, first and second generation drug-eluting stents, bioresorbable and bioabsorbable scaffolds have offered diachronically a great advance against coronary artery disease and have enriched our medical armamentarium. Stented areas constitute vulnerable sites for endothelial damage, endothelial dysfunction, flow turbulence, hemorheologic changes, platelet dysfunction, coagulation changes and fibrinolytic disturbances...
April 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28523012/growth-and-accumulation-of-secondary-metabolites-in-perilla-as-affected-by-photosynthetic-photon-flux-density-and-electrical-conductivity-of-the-nutrient-solution
#2
Na Lu, Emmanuel L Bernardo, Chayanit Tippayadarapanich, Michiko Takagaki, Natsuko Kagawa, Wataru Yamori
The global demand for medicinal plants is increasing. The quality of plants grown outdoors, however, is difficult to control. Myriad environmental factors influence plant growth and directly impact biosynthetic pathways, thus affecting the secondary metabolism of bioactive compounds. Plant factories use artificial lighting to increase the quality of medicinal plants and stabilize production. Photosynthetic photon flux density (PPFD) and electrical conductivity (EC) of nutrient solutions are two important factors that substantially influence perilla (Perilla frutescens, Labiatae) plant growth and quality...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28521336/chemical-ecology-of-antibiotic-production-by-actinomycetes
#3
Anne van der Meij, Sarah F Worsley, Matthew I Hutchings, Gilles P van Wezel
Actinomycetes are a diverse family of filamentous bacteria that produce a plethora of natural products relevant for agriculture, biotechnology and medicine, including the majority of the antibiotics we use in the clinic. Rather than as free-living bacteria, many actinomycetes have evolved to live in symbiosis with among others plants, fungi, insects and sponges. As a common theme, these organisms profit from the natural products and enzymes produced by the actinomycetes, for example, for protection against pathogenic microbes, for growth promotion or for the degradation of complex natural polymers such as lignocellulose...
May 1, 2017: FEMS Microbiology Reviews
https://www.readbyqxmd.com/read/28517988/the-promise-and-the-hype-of-personalised-medicine
#4
Tim Maughan
Personalised medicine is widely considered as the way of the future for medicine. However, progress in cancer, with a few outstanding exceptions, has fallen below expectations because of the challenges of tumour heterogeneity and clonal evolution. In both benign and malignant disease, diseases caused by single genetic alterations are more amenable to precision medicine approaches. However, most common diseases are caused by a complex interplay of multiple genetic and environmental factors making personalised medicine far more challenging...
April 2017: New Bioethics: a Multidisciplinary Journal of Biotechnology and the Body
https://www.readbyqxmd.com/read/28516248/environmental-toxicants-incidence-of-degenerative-diseases-and-therapies-from-the-epigenetic-point-of-view
#5
REVIEW
Mahshid Hodjat, Soheila Rahmani, Fazlullah Khan, Kamal Niaz, Mona Navaei-Nigjeh, Solmaz Mohammadi Nejad, Mohammad Abdollahi
Epigenotoxicology is an emerging field of study that investigates the non-genotoxic epigenetic effects of environmental toxicants resulting in alteration of normal gene expression and disruption of cell function. Recent findings on the role of toxicant-induced epigenetic modifications in the development of degenerative diseases have opened up a promising research direction to explore epigenetic therapy approaches and related prognostic biomarkers. In this review, we presented comprehensive data on epigenetic alterations identified in various diseases, including cancer, autoimmune disorders, pulmonary conditions as well as cardiovascular, gastrointestinal and bone disease...
May 17, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28511137/effects-of-ibuprofen-diclofenac-and-paracetamol-on-hatch-and-motor-behavior-in-developing-zebrafish-danio-rerio
#6
Liang Xia, Liang Zheng, Jun Liang Zhou
Non-steroidal anti-inflammatory drugs (NSAIDs) which are widely used as pain relief medicines are causing increasing environmental concern due to their incomplete removal in wastewater treatment plant and potential toxicity on endocrine, kidney and reproduction in teleost fish. This study focused on the effects of widely used ibuprofen, diclofenac and paracetamol on the hatch and motor ability of early-stage zebrafish, by exposing embryos to the target chemicals at 5, 50 and 500 μg/L starting from 6 h postfertilization (hpf)...
May 10, 2017: Chemosphere
https://www.readbyqxmd.com/read/28507539/new-insight-into-inter-kingdom-communication-horizontal-transfer-of-mobile-small-rnas
#7
REVIEW
Geyu Zhou, Yu Zhou, Xi Chen
Small RNAs (sRNAs), including small interfering RNAs (siRNAs) and microRNAs (miRNAs), are conventionally regarded as critical molecular regulators of various intracellular processes. However, recent accumulating evidence indicates that sRNAs can be transferred within cells and tissues and even across species. In plants, nematodes and microbes, these mobile sRNAs can mediate inter-kingdom communication, environmental sensing, gene expression regulation, host-parasite defense and many other biological functions...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28503417/indoor-outdoor-not-voluptuary-habit-pollution-and-sleep-disordered-breathing-in-children-a-systematic-review
#8
Laura Tenero, Giorgio Piacentini, Luana Nosetti, Emma Gasperi, Michele Piazza, Marco Zaffanello
BACKGROUND: Exposure to environmental pollutants is advocated to be a major risk factor, with increased morbidity and mortality in humans due to acute and chronic airway inflammation. The aim of the present review is to show the literature research regarding the link between the sleep-disordered breathing and exposure to indoor/outdoor pollution in children. We hypothesized that environmental air pollution can play a role in childhood sleep-disordered breathing. METHODS: We conducted an electronic search in Medline (with PubMed interface), Scopus and the ISI Web of Science using the keywords "sleep" or "sleep apnea" or "sleep disordered breathing" and "pollution" and "children" in "Title/Abstract/Keywords", with language restriction (non-English paper) and no date limitation to present...
April 2017: Translational pediatrics
https://www.readbyqxmd.com/read/28502796/in-vivo-reprogramming-for-heart-regeneration-a-glance-at-efficiency-environmental-impacts-challenges-and-future-directions
#9
REVIEW
Behnam Ebrahimi
Replacing dying or diseased cells of a tissue with new ones that are converted from patient's own cells is an attractive strategy in regenerative medicine. In vivo reprogramming is a novel strategy that can circumvent the hurdles of autologous/allogeneic cell injection therapies. Interestingly, studies have demonstrated that direct injection of cardiac transcription factors or specific miRNAs into the infarct border zone of murine hearts following myocardial infarction converts resident cardiac fibroblasts into functional cardiomyocytes...
May 11, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28496464/using-%C3%A3-cyclodextrin-and-arabic-gum-as-wall-materials-for-encapsulation-of-saffron-essential-oil
#10
Mohsen Atefi, Kooshan Nayebzadeh, Abdorreza Mohammadi, Amir Mohammad Mortazavian
Saffron essential oil has a pleasant aroma and medicinal activities. However, it is sensible into the environmental condition. Therefore, it should be protected against unwanted changes during storage or processing. Encapsulation is introduced as a process by which liable materials are protected from unwanted changes. In the present study, different ratios (0:100, 25:75, 50:50, 75:25, and 100:0) of ß-cyclodextrin (ß-CD) and arabic gum (GA) were used as wall martial for encapsulation saffron essential oil...
2017: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/28494313/heavy-metals-translocation-and-accumulation-from-the-rhizosphere-soils-to-the-edible-parts-of-the-medicinal-plant-fengdan-paeonia-ostii-grown-on-a-metal-mining-area-china
#11
Zhang Jun Shen, De Cong Xu, Yan Song Chen, Zhen Zhang
Fengdan (Paeonia ostii) is one of Chinese 34 famous medicinal materials. This study investigated the concentrations of Arsenic (As), Chromium (Cr), Cadmium (Cd), Copper (Cu), Lead (Pb), Iron (Fe), Manganese (Mn), and Zinc (Zn) in rhizosphere soils, cortex mouton and seeds of Fengdan planted in a metal mining area, China. The mean concentrations of As, Cd, Cu, and Zn in the rhizosphere soils were above the limits set by the Chinese Soil Environmental Quality Standard (GB 15618-1995). The contamination factor (CF) of Cd was >5, while it was >2for As, Cu, Pb, and Zn in all the soils...
May 8, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28494303/hemocompatibility-of-inhaled-environmental-nanoparticles-potential-use-of-in-vitro-testing
#12
REVIEW
Eleonore Fröhlich
Hemocompatibility testing is an important part in the evaluation of nano-based medicines. However, it is not systematically used for the assessment of environmental particles since they do not come in contact with blood immediately. Studies on human exposure to air-borne particles and pulmonary exposure of rodents have reported alterations in blood physiology. It is not clear, whether these effects are majorly caused by tissue inflammation or translocated particles in blood. This review addresses the question, if in vitro hemocompatibility testing could help in the risk evaluation of inhaled particles...
April 27, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28493060/synthetic-turf-fields-crumb-rubber-and-alleged-cancer-risk
#13
Archie Bleyer
Most synthetic turf fields have crumb rubber interspersed among the simulated grass fibers to reduce athletic injuries by allowing users to turn and slide more readily as they play sports or exercise on the fields. Recently, the crumbs have been implicated in causing cancer in adolescents and young adults who use the fields, particularly lymphoma and primarily in soccer goalkeepers. This concern has led to the initiation of large-scale studies by local and federal governments that are expected to take years to complete...
May 11, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28492968/-monitoring-methods-and-their-results-in-environmental-medicine-implications-for-medical-counsellors
#14
REVIEW
E Wolter, A Neumann, W Straff
Besides effect and environmental monitoring, human biomonitoring (HBM) offers an attractive method for analyzing the distribution and intensity of anthropogenic environmental pollutants in individuals or in particular groups of the population. However, no assessment values of comparable reliability are available to enable an interpretation of the results of environmental studies from the viewpoint of environmental health. This must be taken into account when reporting findings of such studies as well as in medical consultation, in order to avoid overdiagnosis and unnecessary anxiety for the participant...
May 10, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28490744/precision-radiology-predicting-longevity-using-feature-engineering-and-deep-learning-methods-in-a-radiomics-framework
#15
Luke Oakden-Rayner, Gustavo Carneiro, Taryn Bessen, Jacinto C Nascimento, Andrew P Bradley, Lyle J Palmer
Precision medicine approaches rely on obtaining precise knowledge of the true state of health of an individual patient, which results from a combination of their genetic risks and environmental exposures. This approach is currently limited by the lack of effective and efficient non-invasive medical tests to define the full range of phenotypic variation associated with individual health. Such knowledge is critical for improved early intervention, for better treatment decisions, and for ameliorating the steadily worsening epidemic of chronic disease...
May 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28489402/iodine-catalyzed-facile-approach-to-sulfones-employing-tosmic-as-a-sulfonylating-agent
#16
Lingaswamy Kadari, Radha Krishna Palakodety, Lakshmi Prapurna Yallapragada
A novel iodine-catalyzed functionalization of a variety of olefins and alkynes and direct decarboxylative functionalization of cinnamic and propiolic acids with TosMIC to provide access to various vinyl, allyl, and β-iodo vinylsulfones is described. This simple, efficient, and environmentally benign approach employing inexpensive molecular iodine as a catalyst demonstrates a versatile protocol for the synthesis of highly valuable sulfones, rendering it attractive to both synthetic and medicinal chemistry.
May 10, 2017: Organic Letters
https://www.readbyqxmd.com/read/28487212/mapping-the-ecoepidemiology-of-zika-virus-infection-in-urban-and-rural-areas-of-pereira-risaralda-colombia-2015-2016-implications-for-public-health-and-travel-medicine
#17
Alfonso J Rodriguez-Morales, Pablo Ruiz, Javier Tabares, Carlos Augusto Ossa, Maria Camila Yepes-Echeverry, Valeria Ramirez-Jaramillo, Maria Leonor Galindo-Marquez, Carlos Julian García-Loaiza, Juan Alejandro Sabogal-Roman, Esteban Parra-Valencia, Guillermo J Lagos-Grisales, Carlos O Lozada-Riascos, Cornelis A de Pijper, Martin P Grobusch
OBJECTIVE: Geographical information systems (GIS) have been demonstrated earlier to be of great use to inform public health action against vector-borne infectious diseases. METHODS: Using surveillance data on the ongoing ZIKV outbreak from Pereira, Colombia (2015-2016), we estimated incidence rates (cases/100,000 population), and developed maps correlating with the ecoepidemiology of the area. RESULTS: Up to October 8, 2016, 439 cases of ZIKV were reported in Pereira (93 cases/100,000 pop...
May 6, 2017: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/28486083/progress-in-mass-spectrometry-based-proteomics-in-hypoxia-related-diseases-and-high-altitude-medicine
#18
Zhiqi Gao, Gang Luo, Bing Ni
Human migration, influenced by social conflict and natural disasters as well as global climate change, has become recognized as a major "planetary force." It has also brought to the forefront, new specialties of integrative biology-such as high-altitude medicine-and the impact of hitherto understudied environmental factors on human pathophysiology in these new geographical settings. For people migrating to or living in high-altitude regions, environmental hypoxia is a primary challenge. Decreased partial pressure of oxygen in environmental air, caused by lower barometric pressure, puts living organisms in a hypoxic state...
May 9, 2017: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/28481398/evolutionary-trade-offs-in-kidney-injury-and-repair
#19
REVIEW
Yutian Lei, Hans-Joachim Anders
Evolutionary medicine has proven helpful to understand the origin of human disease, e.g. in identifying causal roles of recent environmental changes impacting on human physiology (environment-phenotype mismatch). In contrast, diseases affecting only a limited number of members of a species often originate from evolutionary trade-offs for usually physiologic adaptations assuring reproductive success in the context of extrinsic threats. For example, the G1 and G2 variants of the APOL1 gene supporting control of Trypanosoma infection come with the trade-off that they promote the progression of kidney disease...
May 8, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28479371/udp-glucuronosyltransferases-ugts-and-their-related-metabolic-cross-talk-with-internal-homeostasis-a-systematic-review-of-ugt-isoforms-for-precision-medicine
#20
REVIEW
Na Yang, Runbin Sun, Xiaoying Liao, Jiye Aa, Guangji Wang
UDP-glucuronosyltransferases (UGTs) are the primary phase II enzymes catalyzing the conjugation of glucuronic acid to the xenobiotics with polar groups for facilitating their clearance. The UGTs belong to a superfamily that consists of diverse isoforms possessing distinct but overlapping metabolic activity. The abnormality or deficiency of UGTs in vivo is highly associated with some diseases, efficacy and toxicity of drugs, and precisely therapeutic personality. Despite the great effects and fruitful results achieved, to date, the expression and functions of individual UGTs have not been well clarified, the inconsistency of UGTs is often observed in human and experimental animals, and the complex regulation factors affecting UGTs have not been systematically summarized...
May 4, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
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