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https://www.readbyqxmd.com/read/29928982/heterogeneity-and-the-origins-of-asthma
#1
REVIEW
Rebecca Scherzer, Mitchell H Grayson
OBJECTIVE: It is a well-known fact that there is significant heterogeneity in the origins of asthma in adults and children. This article examines the roots of asthma across the ages including atopy, the role of the microbiome and viral infections, along with comorbidities/confounders such as obesity, aspirin-exacerbated respiratory disease (AERD), neutrophilic asthma, cigarette smoking and the possibility of an asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome. DATA SOURCES: Data was taken from various scientific search engines including PubMed and Science Direct databases...
June 18, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29928293/turning-natural-adaptations-to-oncogenic-factors-into-an-ally-in-the-war-against-cancer
#2
Marion Vittecoq, Mathieu Giraudeau, Tuul Sepp, David J Marcogliese, Marcel Klaassen, François Renaud, Beata Ujvari, Frédéric Thomas
Both field and experimental evolution studies have demonstrated that organisms naturally or artificially exposed to environmental oncogenic factors can, sometimes rapidly, evolve specific adaptations to cope with pollutants and their adverse effects on fitness. Although numerous pollutants are mutagenic and carcinogenic, little attention has been given to exploring the extent to which adaptations displayed by organisms living in oncogenic environments could inspire novel cancer treatments, through mimicking the processes allowing these organisms to prevent or limit malignant progression...
July 2018: Evolutionary Applications
https://www.readbyqxmd.com/read/29927718/multiomics-data-triangulation-for-asthma-candidate-biomarkers-and-precision-medicine
#3
Matija Pecak, Peter Korošec, Tanja Kunej
Asthma is a common complex disorder and has been subject to intensive omics research for disease susceptibility and therapeutic innovation. Candidate biomarkers of asthma and its precision treatment demand that they stand the test of multiomics data triangulation before they can be prioritized for clinical applications. We classified the biomarkers of asthma after a search of the literature and based on whether or not a given biomarker candidate is reported in multiple omics platforms and methodologies, using PubMed and Web of Science, we identified omics studies of asthma conducted on diverse platforms using keywords, such as asthma, genomics, metabolomics, and epigenomics...
June 2018: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/29927660/integration-of-behavioral-medicine-competencies-into-physiotherapy-curriculum-in-an-exemplary-swedish-program-rationale-process-and-review
#4
Maria Sandborgh, Elizabeth Dean, Eva Denison, Maria Elvén, Johanna Fritz, Petra von Heideken Wågert, Johan Moberg, Thomas Overmeer, Åsa Snöljung, Ann-Christin Johansson, Anne Söderlund
In 2004, Mälardalen University, Sweden, introduced a new undergraduate entry-level physiotherapy program. Program developers constructed the curriculum with behavioral medicine content that reflected the contemporary definition and values of the physiotherapy profession aligning it with current best practices, evidence, and the International Classification of Functioning, Disability, and Health (ICF). The new curriculum conceptualized movement and function as modifiable behaviors in that they reflect behavioral contingencies, perceptions, beliefs, and lifestyle factors as well as pathophysiology and environmental factors...
June 21, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29924150/environmental-variables-and-errors-in-the-preparation-and-administration-of-medicines
#5
Francisco Gilberto Fernandes Pereira, Márcia Barroso Camilo de Ataíde, Ricardo Leal Silva, Eugenie Desirèe Rabelo Néri, Gerdane Celene Nunes Carvalho, Joselany Áfio Caetano
OBJECTIVE: to identify the relationship between environmental factors and errors in the preparation and administration of antibacterial. METHOD: an observational, cross-sectional study conducted between August and December, 2014 in two clinical units. The sample consisted of 265 doses of medication, observed in different shifts that through a form had the environmental conditions of noise, illumination, humidity, temperature and physical space measured in the preparation and administration stages...
May 2018: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29921803/computer-assisted-learning-assessment-of-the-veterinary-virtual-anatomy-education-software-ivala%C3%A2
#6
William Brady Little, Elpida Artemiou, Anne Conan, Cathryn Sparks
Although cadaveric dissection has historically been the cornerstone of anatomical education, it comes at the cost of some emotional, moral, safety, and environmental concerns. Computer assisted learning (CAL) programs are an increasingly common solution to these issues; however, research regarding the efficacy of high fidelity simulation is limited. The traditional first semester veterinary gross anatomy course curriculum at Ross University School of Veterinary Medicine (RUSVM) was supplemented with a web based virtual anatomy program, IVALA™ (www...
June 19, 2018: Veterinary Sciences
https://www.readbyqxmd.com/read/29921725/preanalytical-processing-and-biobanking-procedures-of-biological-samples-for-metabolomics-research-a-white-paper-community-perspective-for-precision-medicine-and-pharmacometabolomics-task-group-the-metabolomics-society-initiative
#7
REVIEW
Jennifer A Kirwan, Lorraine Brennan, David Broadhurst, Oliver Fiehn, Marta Cascante, Warwick B Dunn, Michael A Schmidt, Vidya Velagapudi
BACKGROUND: The metabolome of any given biological system contains a diverse range of low molecular weight molecules (metabolites), whose abundances can be affected by the timing and method of sample collection, storage, and handling. Thus, it is necessary to consider the requirements for preanalytical processes and biobanking in metabolomics research. Poor practice can create bias and have deleterious effects on the robustness and reproducibility of acquired data. CONTENT: This review presents both current practice and latest evidence on preanalytical processes and biobanking of samples intended for metabolomics measurement of common biofluids and tissues...
June 19, 2018: Clinical Chemistry
https://www.readbyqxmd.com/read/29916594/-exposome-from-an-intuition-to-a-mandatory-research-field-in-occupational-and-enviromental-medicine
#8
Matteo Paganelli, Giuseppe De Palma, Pietro Apostoli
OBJECTIVES: As Genomics aims at the collective characterization and quantification of genes, exposomics refers to the totality of lifetime environmental exposures, consisting in a novel approach to studying the role of the environment in human disease. The aim is to assess all human environmental and occupational exposures in order to better understand their contribution to human diseases. The "omics" revolution infact mostly regards the underlying method: scientific knowledge is expected to come from the analysis of increasingly extensive databases...
November 2017: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
https://www.readbyqxmd.com/read/29916432/approach-to-family-assessment-and-intervention
#9
Anand Krishnan, Priyamadhaba Behera, Baridalyne Nongkynrih
Background.: Family studies are an integral part of teaching of community medicine to all undergraduate medical and nursing students. It enhances the understanding of students about social determinants and multifactorial causation of disease. However, there is no standard approach towards it and it is seen as a clinical presentation with some elements of family included. We describe a systematic and comprehensive approach to a family study. Methods.: Based on the existing literature and personal experience, we identified 11 domains under the acronym Family ASSESSMENT-Structure, Socioeconomic, Sickness, Nutritional, Educational, Environmental, Affordability, System (health), Mental, Family influence, Threats...
September 2017: National Medical Journal of India
https://www.readbyqxmd.com/read/29915697/dynamic-succession-of-substrate-associated-bacterial-composition-and-function-during-ganoderma-lucidum-growth
#10
Bo Zhang, Lijuan Yan, Qiang Li, Jie Zou, Hao Tan, Wei Tan, Weihong Peng, Xiaolin Li, Xiaoping Zhang
Background: Ganoderma lucidum , a valuable medicinal fungus, is widely distributed in China. It grows alongside with a complex microbial ecosystem in the substrate. As sequencing technology advances, it is possible to reveal the composition and functions of substrate-associated bacterial communities. Methods: We analyzed the bacterial community dynamics in the substrate during the four typical growth stages of G. lucidum using next-generation sequencing. Results: The physicochemical properties of the substrate (e...
2018: PeerJ
https://www.readbyqxmd.com/read/29914367/global-transcriptome-analysis-and-characterization-of-dryopteris-fragrans-l-schott-sporangium-in-different-developmental-stages
#11
Zhen Lu, Qingyang Huang, Tong Zhang, Baozhong Hu, Ying Chang
BACKGROUND: Dryopteris fragrans (D. fragrans) is a potential medicinal fern distributed in volcanic magmatic rock areas under tough environmental condition. Sporangia are important organs for fern reproduction. This study was designed to characterize the transcriptome characteristics of the wild D. fragrans sporangia in three stages (stage A, B, and C) with the aim of uncovering its molecular mechanism of growth and development. RESULTS: Using a HiSeq 4000, 79.81 Gb clean data (each sample is at least 7...
June 18, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29913182/the-genetic-architecture-of-type-1-diabetes-mellitus
#12
REVIEW
Denis M Nyaga, Mark H Vickers, Craig Jefferies, Jo K Perry, Justin M O'Sullivan
Type 1 diabetes mellitus (T1D) is a complex autoimmune disorder characterised by loss of the insulin-producing pancreatic beta cells in genetically predisposed individuals, ultimately resulting in insulin deficiency and hyperglycaemia. T1D is most common among children and young adults, and the incidence is on the rise across the world. The aetiology of T1D is hypothesized to involve genetic and environmental factors that result in the T-cell mediated destruction of pancreatic beta cells. There is a strong genetic risk to T1D; with genome-wide association studies (GWAS) identifying over 60 susceptibility regions within the human genome which are marked by single nucleotide polymorphisms (SNPs)...
June 15, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29911484/the-need-for-an-alternative-method-to-determine-intravascular-volumes
#13
L M Lobigs, P Peeling, B Dawson, Y O Schumacher
It is well described that numerous environmental factors, including exercise, modulate plasma volume (PV). These modulations prove problematic when a number of haematological markers are measured as a concentration in blood plasma. A primary example is haemoglobin concentration ([Hb]), a marker of erythropoiesis commonly used within medicine and also used to detect blood doping. Natural changes in PV can confound [Hb] values when a volume change is detected rather than a true change in haemoglobin mass (Hbmass ) (e...
June 17, 2018: European Journal of Sport Science
https://www.readbyqxmd.com/read/29909308/the-multilevel-antibiotic-induced-perturbations-to-biological-systems-early-life-exposure-induces-long-lasting-damages-to-muscle-structure-and-mitochondrial-metabolism-in-flies
#14
David Renault, Hesham Yousef, Amr A Mohamed
Antibiotics have been increasingly used over the past decades for human medicine, food-animal agriculture, aquaculture, and plant production. A significant part of the active molecules of antibiotics can be released into the environment, in turn affecting ecosystem functioning and biogeochemical processes. At lower organizational scales, these substances affect bacterial symbionts of insects, with negative consequences on growth and development of juveniles, and population dynamics. Yet, the multiple alterations of cellular physiology and metabolic processes have remained insufficiently explored in insects...
June 7, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29909200/epigenetic-control-of-variation-and-stochasticity-in-metabolic-disease
#15
REVIEW
Ilaria Panzeri, John Andrew Pospisilik
BACKGROUND: The alarming rise of obesity and its associated comorbidities represents a medical burden and a major global health and economic issue. Understanding etiological mechanisms underpinning susceptibility and therapeutic response is of primary importance. Obesity, diabetes, and metabolic diseases are complex trait disorders with only partial genetic heritability, indicating important roles for environmental programing and epigenetic effects. SCOPE OF THE REVIEW: We will highlight some of the reasons for the scarce predictability of metabolic diseases...
May 18, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29908570/therapeutic-herbs-confirmed-by-evidence-based-medicine
#16
Carl R Thornfeldt
Mucocutaneous diseases and conditions, including aging, are known to be the result of multiple pathophysiologic anomalies induced by various environmental insults. Creating therapeutic products for these multifactorial diseases and conditions is challenging. Although safety testing is not required for cosmetics and cosmeceuticals, consumer expectation is for products to be effective and well tolerated while maintaining cosmetic elegance. This requires that the finished product being sold to consumers should be tested in human clinical trials for safety profile, efficacy, and scientific integrity...
May 2018: Clinics in Dermatology
https://www.readbyqxmd.com/read/29907156/an-ethnobotanical-survey-of-edible-fungi-in-chuxiong-city-yunnan-china
#17
Dongyang Liu, Hong Cheng, Rainer W Bussmann, Zhiyong Guo, Bo Liu, Chunlin Long
BACKGROUND: Chuxiong, known as "the City of Fungi," is rich in fungal resources and traditional knowledge related to fungal biodiversity. The local environment is an excellent habitat for a wide variety of edible fungi. In addition, the region is home to many ethnic minorities and especially the Yi ethnic group who has a long history for traditionally using fungi as food or medicine. The aims of this review are to provide up-to-date information on the knowledge about, and traditional management of, fungi in this area and give advice on future utilization and conservation...
June 15, 2018: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/29907144/a-rare-chd5-haplotype-and-its-interactions-with-environmental-factors-predicting-hepatocellular-carcinoma-risk
#18
Qin Xiao, Lianzhou Chen, Haiqing Luo, Hongmei Li, Qingming Kong, Fei Jiao, Shifeng Pang, Ming Zhang, Feifei Lan, Wenguo Fan, Hui Luo, Tao Tao, Xiao Zhu
BACKGROUND: CHD5 is a conventional tumour-suppressing gene in many tumours. The aim of this study was to determine whether CHD5 variants contribute to the risk of hepatocellular carcinoma (HCC). METHODS: Gene variants were identified using next-generation sequencing targeted on referenced mutations followed by TaqMan genotyping in two case-control studies. RESULTS: We discovered a rare variant (haplotype AG) in CHD5 (rs12564469-rs9434711) that was markedly associated with the risk of HCC in a Chinese population...
June 15, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29905160/-the-significance-of-cryptosporidiosis-for-the-health-of-calves-in-switzerland
#19
P Olias, I Dettwiler, A Hemphill, P Deplazes, A Steiner, M Meylan
Diarrhea in calves is one of the most important cattle diseases in Switzerland. The diagnosis and treatment of calf diarrhea represent a major challenge. Single-celled Cryptosporidium parasites are the most prevalent causative agents of calf diarrhea besides rotavirus in the first weeks of life, and are responsible for about 50% of diarrheal cases. Cryptosporidium parvum has been described as a cause of diarrhea in one to three weeks old calves since the 1970s. Oral ingestion of persistent environmental oocysts results in severe diarrhea lasting four to six days and shedding of large numbers of infectious oocysts...
June 2018: Schweizer Archiv Für Tierheilkunde
https://www.readbyqxmd.com/read/29904888/olfactory-dysfunction-in-neurodegenerative-diseases
#20
REVIEW
Concepció Marin, Dolores Vilas, Cristóbal Langdon, Isam Alobid, Mauricio López-Chacón, Antje Haehner, Thomas Hummel, Joaquim Mullol
PURPOSE OF REVIEW: The sense of smell is today one of the focuses of interest in aging and neurodegenerative disease research. In several neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease, the olfactory dysfunction is one of the initial symptoms appearing years before motor symptoms and cognitive decline, being considered a clinical marker of these diseases' early stages and a marker of disease progression and cognitive decline. Overall and under the umbrella of precision medicine, attention to olfactory function may help to improve chances of success for neuroprotective and disease-modifying therapeutic strategies...
June 15, 2018: Current Allergy and Asthma Reports
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