Read by QxMD icon Read


Luce Farine, Jennifer Jelk, Jae-Yeon Choi, Dennis R Voelker, Jon Nunes, Terry K Smith, Peter Bütikofer
Phosphatidylethanolamine (PE) and phosphatidylserine (PS) are ubiquitously expressed and metabolically interconnected glycerophospholipids in eukaryotes and prokaryotes. In Trypanosoma brucei, PE synthesis has been shown to occur mainly via the Kennedy pathway, one of the three routes leading to PE synthesis in eukaryotes, while PS synthesis has not been studied experimentally. We now reveal the importance of T. brucei PS synthase 2 (TbPSS2) and T. brucei PS decarboxylase (TbPSD), two key enzymes involved in aminophospholipid synthesis, for trypanosome viability...
January 31, 2017: Molecular Microbiology
Christopher C Surek, Eva Guisantes, Kenna Schnarr, Glenn Jelks, Javier Beut
BACKGROUND: The purpose of this study was to examine the anatomical principles of lip structure as they relate to individualized lip enhancement procedures and to describe a technique that does not violate lip mucosa during injection. METHODS: A retrospective analysis of patients undergoing lip enhancement procedures between 2001 and 2014 was performed. Preprocedural and postprocedural photographs were analyzed for lip subunit changes. A stepwise treatment algorithm targeting specific anatomical subunits of lip is described...
October 2016: Plastic and Reconstructive Surgery
Sacha Williams, Aneesh Pirlamarla, William Rahal, Katie Weichman, Evan Garfein, Glenn Jelks, Oren Tepper
BACKGROUND: The American Society for Aesthetic Plastic Surgery (ASAPS) sponsors an annual conference that promotes education, advocacy, and care. There, researchers deliver abstracts as podium and poster presentations. Subsequently, ASAPS encourages submitting these research findings for publication. Yet, many never become published manuscripts. OBJECTIVES: To quantify the conversion rates of oral abstract presentations to publication from 1995 to 2010. Secondary objectives included evaluating trends in presentations, publications, time to publication, and published journal distribution...
February 2017: Aesthetic Surgery Journal
Chantal B F Vogels, Jelke J Fros, Giel P Göertz, Gorben P Pijlman, Constantianus J M Koenraadt
BACKGROUND: Outbreaks of West Nile virus (WNV) have not occurred in northern Europe despite nearby circulation of WNV in the southern part of the continent. The main vector for WNV, the mosquito Culex (Cx.) pipiens, consists of two behaviorally distinct biotypes, pipiens and molestus, which can form hybrids. Although temperature has been shown to influence vector competence of Cx. pipiens for WNV and biotypes are differentially susceptible towards infection, the interaction between the two has not been elucidated...
2016: Parasites & Vectors
Jelke J Fros, Gorben P Pijlman
Alphaviruses cause debilitating disease in humans and animals and are transmitted by blood-feeding arthropods, typically mosquitoes. With a traditional focus on two models, Sindbis virus and Semliki Forest virus, alphavirus research has significantly intensified in the last decade partly due to the re-emergence and dramatic expansion of chikungunya virus in Asia, Europe, and the Americas. As a consequence, alphavirus-host interactions are now understood in much more molecular detail, and important novel mechanisms have been elucidated...
2016: Viruses
Carrie S Stern, Jillian E Schreiber, Chris C Surek, Evan S Garfein, Elizabeth B Jelks, Glenn W Jelks, Oren M Tepper
BACKGROUND: Given the widespread use of facial fillers and recent identification of distinct facial fat compartments, a better understanding of three-dimensional surface changes in response to volume augmentation is needed. Advances in three-dimensional imaging technology now afford an opportunity to elucidate these morphologic changes for the first time. METHODS: A cadaver study was undertaken in which volumization of the deep medial cheek compartment was performed at intervals up to 4 cc (n = 4)...
May 2016: Plastic and Reconstructive Surgery
Carrie S Stern, Jillian E Schreiber, Christopher L Surek, Evan S Garfein, Elizabeth B Jelks, Glenn W Jelks, Oren M Tepper
BACKGROUND: Given the widespread use of facial fillers and recent identification of distinct facial fat compartments, a better understanding of 3D surface changes in response to volume augmentation is needed. Advances in 3D imaging technology now afford an opportunity to elucidate these morphological changes for the first time. METHODS: A cadaver study was undertaken in which volumization of the deep medial cheek (DMC) compartment was performed at intervals up to 4cc (n=4)...
January 12, 2016: Plastic and Reconstructive Surgery
Jelke J Fros, Corinne Geertsema, Karima Zouache, Jim Baggen, Natalia Domeradzka, Daniël M van Leeuwen, Jacky Flipse, Just M Vlak, Anna-Bella Failloux, Gorben P Pijlman
BACKGROUND: Chikungunya virus (CHIKV) is an arthritogenic alphavirus (family Togaviridae), transmitted by Aedes species mosquitoes. CHIKV re-emerged in 2004 with multiple outbreaks worldwide and recently reached the Americas where it has infected over a million individuals in a rapidly expanding epidemic. While alphavirus replication is well understood in general, the specific function (s) of non-structural protein nsP3 remain elusive. CHIKV nsP3 modulates the mammalian stress response by preventing stress granule formation through sequestration of G3BP...
2015: Parasites & Vectors
Jelke J Fros, Corinne Geertsema, Chantal B Vogels, Peter P Roosjen, Anna-Bella Failloux, Just M Vlak, Constantianus J Koenraadt, Willem Takken, Gorben P Pijlman
BACKGROUND: West Nile virus (WNV) is a highly pathogenic flavivirus transmitted by Culex spp. mosquitoes. In North America (NA), lineage 1 WNV caused the largest outbreak of neuroinvasive disease to date, while a novel pathogenic lineage 2 strain circulates in southern Europe. To estimate WNV lineage 2 epidemic potential it is paramount to know if mosquitoes from currently WNV-free areas can support further spread of this epidemic. METHODOLOGY/PRINCIPAL FINDINGS: We assessed WNV vector competence of Culex pipiens mosquitoes originating from north-western Europe (NWE) in direct comparison with those from NA...
2015: PLoS Neglected Tropical Diseases
Oren M Tepper, Douglas Steinbrech, Melanie H Howell, Elizabeth B Jelks, Glenn W Jelks
BACKGROUND: Lateral canthal procedures are often indicated to correct or prevent lower eyelid malposition. When determining an appropriate lateral canthal procedure, planning is essential and includes proper analysis and identification of any contributory anatomical factors. METHODS: A 12-month retrospective review was performed on patients undergoing lateral canthal procedures. Important components of the preoperative examination were studied to relate patient anatomy and results...
July 2015: Plastic and Reconstructive Surgery
Christopher C Surek, Javier Beut, Robert Stephens, Glenn Jelks, Jerome Lamb
BACKGROUND: The study was conducted to construct an anatomically inspired midfacial analysis facilitating safe, accurate, and dynamic nonsurgical rejuvenation. Emphasis is placed on determining injection target areas and adverse event zones. METHODS: Twelve hemifacial fresh cadavers were dissected in a layered fashion. Dimensional measurements between the midfacial fat compartments, prezygomatic space, mimetic muscles, and neurovascular bundles were used to develop a topographic analysis for clinical injections...
May 2015: Plastic and Reconstructive Surgery
Christopher Surek, Javier Beut, Robert Stephens, Jerome Lamb, Glenn Jelks
BACKGROUND: In nonsurgical facial rejuvenation, autologous fat and dermal fillers have become an effective method to achieve symmetry and balance of the midface. Nonsurgical techniques that target the dynamic anatomical relationships existing in the midface can improve rejuvenation outcomes in this commonly augmented region. OBJECTIVES: The authors described techniques for fat compartment and potential space volumization of the midface via a standardized and reproducible technique...
February 2015: Aesthetic Surgery Journal
Andrea Jelks, Monica Berletti, Liliana Hamlett, Michele Hugin
Disseminated intravascular coagulation (DIC) is an uncommon but potentially catastrophic complication of postpartum hemorrhage. We describe two cases of massive postpartum hemorrhage complicated by DIC that were successfully temporized with combined use of the Bakri balloon and nonpneumatic antishock garment (NASG) during massive transfusion. In the first case, a healthy, term gravida underwent emergent cesarean for fetal bradycardia during labor induction. 10 minutes after completion of surgery, brisk vaginal hemorrhage of nonclotting blood from fulminant DIC resulted in maternal shock...
2015: Case Reports in Obstetrics and Gynecology
Jelke J Fros, Lee D Major, Florine E M Scholte, Joy Gardner, Martijn J van Hemert, Andreas Suhrbier, Gorben P Pijlman
The unfolded protein response (UPR) is a cellular defence mechanism against high concentrations of misfolded protein in the endoplasmic reticulum (ER). In the presence of misfolded proteins, ER-transmembrane proteins PERK and IRE1α become activated. PERK phosphorylates eIF2α leading to a general inhibition of cellular translation, whilst the expression of transcription factor ATF4 is upregulated. Active IRE1α splices out an intron from XBP1 mRNA, to produce a potent transcription factor. Activation of the UPR increases the production of several proteins involved in protein folding, degradation and apoptosis...
March 2015: Journal of General Virology
Robert Wallerstein, Andrea Jelks, Matthew J Garabedian
OBJECTIVE: Cell-free DNA (cfDNA) offers highly accurate noninvasive screening for Down syndrome. Incorporating it into routine care is complicated. We present our experience implementing a novel program for cfDNA screening, emphasizing patient education, genetic counseling, and resource management. STUDY DESIGN: Beginning in January 2013, we initiated a new patient care model in which high-risk patients for aneuploidy received genetic counseling at 12 weeks of gestation...
2014: Journal of Pregnancy
Koen W R van Cleef, Joël T van Mierlo, Pascal Miesen, Gijs J Overheul, Jelke J Fros, Susan Schuster, Marco Marklewitz, Gorben P Pijlman, Sandra Junglen, Ronald P van Rij
RNA interference (RNAi) is a crucial antiviral defense mechanism in insects, including the major mosquito species that transmit important human viruses. To counteract the potent antiviral RNAi pathway, insect viruses encode RNAi suppressors. However, whether mosquito-specific viruses suppress RNAi remains unclear. We therefore set out to study RNAi suppression by Culex Y virus (CYV), a mosquito-specific virus of the Birnaviridae family that was recently isolated from Culex pipiens mosquitoes. We found that the Culex RNAi machinery processes CYV double-stranded RNA (dsRNA) into viral small interfering RNAs (vsiRNAs)...
July 2014: Nucleic Acids Research
William F Smith-Vaniz, Howard L Jelks
An historical account is given for the ichthyological research at St. Croix, U. S. Virgin Islands, followed by an annotated list of 544 species of mostly marine shore fishes known or reported from the island to depths of 200 m. Color photographs are included for 103 of these species. Collections made at Buck Island Reef National Monument with the ichthyocide rotenone in 2001 and 2005 increased the known ichthyofauna by about 80 species. The rational for inclusion of each species in the checklist is given, with remarks for those species for which additional documentation or voucher specimens are needed...
2014: Zootaxa
Martijn Wieling, John Nerbonne, Jelke Bloem, Charlotte Gooskens, Wilbert Heeringa, R Harald Baayen
In this study we develop pronunciation distances based on naive discriminative learning (NDL). Measures of pronunciation distance are used in several subfields of linguistics, including psycholinguistics, dialectology and typology. In contrast to the commonly used Levenshtein algorithm, NDL is grounded in cognitive theory of competitive reinforcement learning and is able to generate asymmetrical pronunciation distances. In a first study, we validated the NDL-based pronunciation distances by comparing them to a large set of native-likeness ratings given by native American English speakers when presented with accented English speech...
2014: PloS One
Jelke J Fros, Erika van der Maten, Just M Vlak, Gorben P Pijlman
Alphavirus nonstructural protein 2 (nsP2) has pivotal roles in viral RNA replication, host cell shutoff, and inhibition of antiviral responses. Mutations that individually rendered other alphaviruses noncytopathic were introduced into chikungunya virus nsP2. Results show that (i) nsP2 mutation P718S only in combination with KR649AA or adaptive mutation D711G allowed noncytopathic replicon RNA replication, (ii) prohibiting nsP2 nuclear localization abrogates inhibition of antiviral interferon-induced JAK-STAT signaling, and (iii) nsP2 independently affects RNA replication, cytopathicity, and JAK-STAT signaling...
September 2013: Journal of Virology
Jennifer Jelk, Ningguo Gao, Mauro Serricchio, Aita Signorell, Remo S Schmidt, James D Bangs, Alvaro Acosta-Serrano, Mark A Lehrman, Peter Bütikofer, Anant K Menon
Mature dolichol-linked oligosaccharides (mDLOs) needed for eukaryotic protein N-glycosylation are synthesized by a multistep pathway in which the biosynthetic lipid intermediate Man5GlcNAc2-PP-dolichol (M5-DLO) flips from the cytoplasmic to the luminal face of the endoplasmic reticulum. The endoplasmic reticulum membrane protein Rft1 is intimately involved in mDLO biosynthesis. Yeast genetic analyses implicated Rft1 as the M5-DLO flippase, but because biochemical tests challenged this assignment, the function of Rft1 remains obscure...
July 12, 2013: Journal of Biological Chemistry
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"