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glycogen,ethanol,extract

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https://www.readbyqxmd.com/read/29695179/extraction-of-the-same-novel-homoglycan-mixture-from-two-different-strains-of-bifidobacterium-animalis-and-three-strains-of-bifidobacterium-breve
#1
M Alhudhud, S Sadiq, H N Ngo, C Hidalgo-Cantabrana, P Ruas-Madiedo, D van Sinderen, P N Humphreys, A P Laws
Three strains of Bifidobacterium breve (JCM 7017, JCM 7019 and JCM 2258) and two strains of Bifidobacterium animalis subsp. lactis (AD011 and A1dOxR) were grown in broth cultures or on plates, and a standard exopolysaccharide extraction method was used in an attempt to recover exocellular polysaccharides. When the extracted materials were analysed by NMR it was clear that mixtures of polysaccharides were being isolated including exopolysaccharides (EPS) cell wall polysaccharides and intracellular polysaccharides...
June 15, 2018: Beneficial Microbes
https://www.readbyqxmd.com/read/29572140/preparation-characterization-and-in-vivo-antidiabetic-effects-of-polysaccharides-from-pachyrrhizus-erosus
#2
Qingyu Ma, Ling Yuan, Yongliang Zhuang
Polysaccharides were extracted from Pachyrrhizus erosus (PEP) and three fractions (PEP60, PEP80 and PEP95) were separated by ethanol precipitation. Antidiabetic activities of three fractions were evaluated by streptozotocin-induced diabetic mouse model. Three PEP fractions reduced fasting blood glucose levels in mice, and regulated the levels of glycated serum protein, total triglyceride and total cholesterol in serum. In liver, the levels of glycogen content, glutathione peroxidase and superoxide dismutase activities and lipid peroxidation were recovered by PEP fractions...
July 15, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29518051/multi-target-anti-alzheimer-activities-of-four-prenylated-compounds-from-psoralea-fructus
#3
Qing-Xia Xu, Ying Hu, Gui-Yang Li, Wei Xu, Ying-Tao Zhang, Xiu-Wei Yang
Alzheimer's disease (AD) is an age-related neurodegenerative disease that is mediated by multiple signaling pathways. In recent years, the components of Psoralea Fructus (PF) have demonstrated some anti-Alzheimer effects both in vitro and in vivo. To further reveal the active compounds of PF and their mechanisms regulating key targets of AD, in this study, we identified four prenylated compounds from the 70% ethanolic aqueous extract of PF, namely bavachin, bavachinin, bavachalcone, and isobavachalcone. Multi-target bioactivity analysis showed that these compounds could differentially inhibit neuroinflammation, oxidative damage, and key AD-related protein targets, such as amyloid β-peptide 42, β-secretase, glycogen synthase kinase 3β, and acetylcholinesterase...
March 8, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29492105/direct-and-highly-productive-conversion-of-cyanobacteria-arthrospira-platensis-to-ethanol-with-cacl-2-addition
#4
Shimpei Aikawa, Kentaro Inokuma, Satoshi Wakai, Kengo Sasaki, Chiaki Ogino, Jo-Shu Chang, Tomohisa Hasunuma, Akihiko Kondo
Background: The cyanobacterium Arthrospira platensis shows promise as a carbohydrate feedstock for biofuel production. The glycogen accumulated in A. platensis can be extracted by lysozyme-degrading the peptidoglycan layer of the bacterial cell walls. The extracted glycogen can be converted to ethanol through hydrolysis by amylolytic enzymes and fermentation by the yeast Saccharomyces cerevisiae . Thus, in the presence of lysozyme, a recombinant yeast expressing α-amylase and glucoamylase can convert A...
2018: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/29405623/cucurbitane-triterpenoids-from-the-fruits-of-momordica-charantia-improve-insulin-sensitivity-and-glucose-homeostasis-in-streptozotocin-induced-diabetic-mice
#5
Joo-Hui Han, Nguyen Quoc Tuan, Min-Ho Park, Khong Trong Quan, Joonseok Oh, Kyung-Sun Heo, MinKyun Na, Chang-Seon Myung
SCOPE: Momordica charantia (M. charantia) has antidiabetic effects, and cucurbitane-type triterpenoid is one of the compounds of M. charantia. This study aims to investigate whether the new cucurbitane-type triterpenoids affect insulin sensitivity both in vitro and in vivo, and the underlying mechanisms. METHODS AND RESULTS: Four compounds (C1-C4) isolated from the ethanol extract of M. charantia enhance glucose uptake in C2C12 myotubes via insulin receptor substrate-1 (IRS-1) rather than via adenosine monophosphate-activated protein kinase...
April 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29207130/ethanol-extract-from-cnidium-monnieri-l-cusson-induces-cell-cycle-arrest-and-apoptosis-via-regulation-of-the-p53%C3%A2-independent-pathway-in-hepg2-and-hep3b-hepatocellular-carcinoma-cells
#6
Eun Gyeong Lim, Guen Tae Kim, Bo Min Kim, Eun Ji Kim, Sang-Yong Kim, Young Min Kim
Cnidium monnieri (L.) Cusson is a frequently used traditional Chinese medicine that treats gynecological diseases and carbuncles. However, the mechanism of action of C. monnieri remains to be fully elucidated. The present study examined the cell cycle arrest and apoptotic effects resulting from ethanol extract of C. monnieri (CME) in HepG2 (wild‑type p53) and Hep3B (p53‑null) hepatocellular carcinoma cells. An MTT assay was used to confirm the anti‑proliferative effect of CME. The cells were stained with Hoechst 33342 or propidium iodide...
February 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29137190/spirulina-maxima-extract-ameliorates-learning-and-memory-impairments-via-inhibiting-gsk-3%C3%AE-phosphorylation-induced-by-intracerebroventricular-injection-of-amyloid-%C3%AE-1-42-in-mice
#7
Eun-Jeong Koh, Kui-Jin Kim, Ji-Hyeon Song, Jia Choi, Hyeon Yong Lee, Do-Hyung Kang, Ho Jin Heo, Boo-Yong Lee
Spirulina maxima , a microalga containing high levels of protein and many polyphenols, including chlorophyll a and C-phycocyanin, has antioxidant and anti-inflammatory therapeutic effects. However, the mechanisms where by Spirulina maxima ameliorates cognitive disorders induced by amyloid-β 1-42 (Aβ1-42 ) are not fully understood. In this study, we investigated whether a 70% ethanol extract of Spirulina maxima (SM70EE) ameliorated cognitive impairments induced by an intracerebroventricular injection of Aβ1-42 in mice...
November 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29110587/momordica-charantia-extracts-ameliorate-insulin-resistance-by-regulating-the-expression-of-socs-3-and-jnk-in-type-2-diabetes-mellitus-rats
#8
Chunyu Ma, Hongyu Yu, Ying Xiao, Huijiao Wang
CONTEXT: Momordica charantia L. (Cucurbitaceae) has long been widely used as a traditional remedy for diabetes mellitus in some countries. However, detailed antidiabetic mechanisms are largely unknown. OBJECTIVES: This study clarified the ameliorating effects of M. charantia ethanol extracts (MCE) on the insulin resistance in type 2 diabetes mellitus (T2DM) rats. MATERIALS AND METHODS: T2DM rat model was established by high-fat diet and streptozotocin (STZ) injection...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28951243/root-bark-extracts-of-myrianthus-arboreus-p-beauv-cecropiaceae-exhibit-anti-diabetic-potential-by-modulating-hepatocyte-glucose-homeostasis
#9
Pierre B Kasangana, Abir Nachar, Hoda M Eid, Tatjana Stevanovic, Pierre S Haddad
ETHNOPHARMACOLOGICAL RELEVANCE: Myrianthus arboreus P. Beauv. is a tropical tree used in African folk medicine, including for diabetes. However, little research has yet been conducted to support this ethnopharmacological use of this plant. The present study sought to determine the antidiabetic potential of root bark extracts through cell-based bioassays of liver and muscle glucose homeostasis. MATERIALS AND METHODS: Four extracts were obtained from crude root bark powder: 1 aqueous (AQ), 2 ethanol (EtOH), 3 alkaloid enriched (Alk) (obtained from methanol extract) and 4 dichloromethane (Dic) extracts...
September 23, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28914437/salutary-potential-of-ethanolic-extract-of-avocado-fruit-on-anomalous-carbohydrate-metabolic-key-enzymes-in-hepatic-and-renal-tissues-of-hyperglycaemic-albino-rats
#10
U S Mahadeva Rao
OBJECTIVE: To assess the beneficial potential of ethanolic extract of avocado fruit on abnormal carbohydrate metabolic key enzymes in hepatic and renal tissues in streptozotocin (STZ) induced hyperglycemic albino rats. METHODS: Twenty-four male albino rats were randomly divided into four groups with six in each group by simple random sampling method. Group 1 as control rats; Group 2 as STZ induced diabetic rats; Group 3 as diabetic rats treated with avocado fruit extract (AFE), 300 mg/kg as aqueous suspension orally for 30 days; Group 4 as diabetic rats treated with gliclazide (5 mg/kg) in aqueous solution orally for 30 days...
September 15, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28911611/antifatigue-and-increasing-exercise-performance-of-actinidia-arguta-crude-alkaloids-in-mice
#11
Yangyang Liu, Changjiang Liu
Actinidia arguta (Siebold et Zucc.) Planch. ex. Miq. is one of the most recently domesticated fruit species with increasing commercial production worldwide. It is a well-known traditional Chinese medicine and is used to reduce blood glucose and treat atopic dermatitis. In addition, it possesses antioxidant, anticancer, and antiallergic properties. In this study, we investigated the physical antifatigue and exercise performance effects of A. arguta crude alkaloids (AACA) extracted with 70% ethanol. Four groups of male Kunming mice (n = 16) were orally administered AACA at doses of 0 mg/kg/d (vehicle), 50 mg/kg/d (AACA-50), 100 mg/kg/d (AACA-100), or 200 mg/kg/d (AACA-200) for 28 days...
October 2016: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28673757/anti-inflammatory-antiapoptotic-and-proproliferative-effects-of-vitis-vinifera-seed-ethanolic-extract-in-the-liver-of-streptozotocin-nicotinamide-induced-type-2-diabetes-in-male-rats
#12
Nelli Giribabu, Kamarulzaman Karim, Eswar Kumar Kilari, Normadiah M Kassim, Naguib Salleh
OBJECTIVES: Consumption of Vitis vinifera seed has been reported to ameliorate liver pathology in diabetes mellitus; however, the mechanisms underlying its effects remain unknown. In this study, the anti-inflammatory, anti-apoptotic and pro-proliferative effects of the ethanolic seed extract of V. vinifera (VVSEE) in the liver in cases of diabetes were identified. METHODS: Adult male rats with streptozotocin-nicotinamide-induced diabetes were given 50, 100 or 200 mg/kg body weight VVSEE orally for 28 days...
April 2018: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28656090/the-effects-of-ethanol-extract-of-berberis-vulgaris-fruit-on-histopathological-changes-and-biochemical-markers-of-the-liver-damage-in-diabetic-rats
#13
Mohammad Rahimi-Madiseh, Paridokht Karimian, Marzieh Kafeshani, Mahmoud Rafieian-Kopaei
OBJECTIVES: Various studies have shown that the diabetes is associated with liver failure. The objective of this study was determining the effects of Berberis vulgaris fruit on histopathological and biochemical markers of liver in diabetic rats. MATERIALS AND METHODS: In this experimental study, 60 male Wistar rats weighing 200-250 g with free access to water and ad libitum were randomly divided to five twelve-membered groups including healthy control (group 1), diabetic control (group 2, this two groups received distilled water), treated diabetic positive control (group 3) using dose 150 mg/kg/day metformin, and two groups treated with doses 200 (group 4) and 600 (group 5) mg/kg/BW of B...
May 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28428689/experimental-validation-of-antidiabetic-potential-of-cayratia-trifolia-l-domin-an-indigenous-medicinal-plant
#14
Shahid Iqbal Mohammed, Narendra Subhash Salunkhe, Kishor Sukhlal Vishwakarma, Vijay Laxminarayan Maheshwari
The present study was undertaken to evaluate antidiabetic and antioxidant activities of Cayratia trifolia root extract against streptozotocin induced diabetes in experimental rats to scientifically validate its use against diabetes in some parts of India. Ethanolic extract, showing the highest activity in in vitro experiments, was prepared in saline and administered orally to streptozotocin induced albino Wistar diabetic rats for 21 days. Biochemical parameters liver and muscles glycogen and in vivo antioxidant activity in normal, diabetic control, standard (metformin) and treated animals were determined and compared...
June 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28164351/ethanol-induced-male-infertility-effects-of-aqueous-leaf-extract-of-tetracarpidium-conophorum
#15
S F Akomolafe, G Oboh, A A Akindahunsi, A J Afolayan
This study investigated the effects of Tetracarpidium conophorum leaf extract on infertility induced by ethanol in male rats. Thirty rats were randomly divided into six groups of five animals each: Group 1 (positive control) received 0.9% saline only; Group 2 (ethanol alone) were given only 30% ethanol orally at 7 ml/kg body weight per day, thrice in a week; groups 3, 4 and 5 were given ethanol and co-treated with 50, 500 and 1,000 mg/kg body weight of leaf extract, respectively, while Group 6 was given ethanol and co-treated with a fertility drug, clomiphene citrate...
February 6, 2017: Andrologia
https://www.readbyqxmd.com/read/27937039/effects-of-butanol-fraction-of-ziziphus-mucronata-root-ethanol-extract-on-glucose-homeostasis-serum-insulin-and-other-diabetes-related-parameters-in-a-murine-model-for-type-2-diabetes
#16
Mohammed Auwal Ibrahim, Md Shahidul Islam
CONTEXT: Ziziphus mucronata Willd (Rhamnaceae) is currently used in Nigerian traditional treatment of diabetes mellitus. However, detailed information on the antidiabetic potential of the plant parts is presently unknown. OBJECTIVES: The present study investigated the antidiabetic effects of the butanol fraction of Z. mucronata root (ZMBF) in a type 2 diabetes (T2D) model of rats. MATERIALS AND METHODS: T2D was induced in rats by feeding a 10% fructose solution ad libitum for two weeks followed by an intraperitoneal injection of streptozotocin (40 mg/kg bw) and the animals were orally treated with ZMBF 150 or 300 mg/kg bw for five days a week for four weeks...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27884717/activity-based-evaluation-of-a-traditional-ayurvedic-medicinal-plant-saraca-asoca-roxb-de-wilde-flowers-as-estrogenic-agents-using-ovariectomized-rat-model
#17
COMPARATIVE STUDY
Gauri Swar, Sunita Shailajan, Sasikumar Menon
ETHNOPHARMACOLOGICAL RELEVANCE: Saraca asoca (Roxb.) de Wilde, Ashok, is a popular traditional plant used for gynecological disorders. In India, the juice of Ashok flowers is traditionally consumed as a tonic by women in case of uterine disorders. But despite the use, its estrogenic potency is not yet evaluated and thus lacks the scientific recognition and acclaim. AIM OF THE STUDY: This study is designed to investigate the estrogenic potential of standardized ethanolic extract of Saraca asoca flowers (SAF) using ovariectomized (OVX) female albino Wistar rat model...
January 4, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27831639/improvement-of-the-classical-assay-method-for-liver-glycogen-fractions-asg-is-the-main-and-metabolic-active-fraction
#18
H Shokri-Afra, A Ostovar-Ravari, M Rasouli
OBJECTIVE: Acid digestion of animal tissues yields two fractions of glycogen, acid soluble (ASG) and insoluble (AIG). The current study was performed to improve the assay method for glycogen fractions in rat liver in different physiological states. MATERIALS AND METHODS: All steps of the assay were manipulated and optimized to measure the content of ASG and AIG in fed and starved rat liver. RESULTS: In postmortem liver tissue, total glycogen was decreased slowly at 4°C and rapidly at 25°C but was well stabilized at -20°C and -70°C...
October 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27783320/lignans-rich-extract-from-herpetospermum-caudigerum-alleviate-physical-fatigue-in-mice
#19
Shi-Ying Jin, Rui-Sheng Li, Bao-de Shen, Jin-Xia Bai, Ping-Hua Xu, Ling Dai, He Xu, Shi-Xiao Jin, Jin Han, Hai-Long Yuan
OBJECTIVE: To ascertain anti-fatigue constituents and mechanisms of Herpetospermum caudigerum. METHODS: The 80% ethanol extracts of Herpetospermum caudigerum were partitioned with chloroform, ethyl acetate and n-butanol, respectively. Male Kunming mice were divided into 13 groups with 16 mice in each group: a control group fed with water, 9 groups treated with 3 fractions of Herpetospermum caudigerum (chloroform fraction, ethyl acetate fraction and n-butanol fraction) at dose of 80, 160 and 320 mg/kg for the low-dose group, medium-dose group and high-dose group, 3 herpetrione (HPE) treated groups fed with HPE at dose of 15, 30, and 60 mg/kg for the low-dose group, medium-dose group and high-dose group...
November 2016: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27711824/the-effect-of-a-plant-extract-enriched-in-stigmasterol-and-%C3%AE-sitosterol-on-glycaemic-status-and-glucose-metabolism-in-alloxan-induced-diabetic-rats
#20
COMPARATIVE STUDY
Ramith Ramu, Prithvi S Shirahatti, Shivasharanappa Nayakavadi, Vadivelan R, Farhan Zameer, Bhadrapura Lakkappa Dhananjaya, Nagendra Prasad Mn
Banana is an extensively cultivated plant worldwide, mainly for its fruit, while its ancillary product, the banana pseudostem, is consumed as a vegetable and is highly recommended for diabetics in the traditional Indian medicine system. The present study was aimed at elucidating the mechanism of antihyperglycaemia exerted by the ethanol extract of banana pseudostem (EE) and its isolated compounds viz., stigmasterol (C1) and β-sitosterol (C2), in an alloxan-induced diabetic rat model. Diabetic rats which were administered with C1, C2 and EE (100 and 200 mg per kg b...
September 14, 2016: Food & Function
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