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https://www.readbyqxmd.com/read/27909987/orexin-ox2-receptor-antagonists-as-sleep-aids
#1
Laura H Jacobson, Sui Chen, Sanjida Mir, Daniel Hoyer
The discovery of the orexin system represents the single major progress in the sleep field of the last three to four decades. The two orexin peptides and their two receptors play a major role in arousal and sleep/wake cycles. Defects in the orexin system lead to narcolepsy with cataplexy in humans and dogs and can be experimentally reproduced in rodents. At least six orexin receptor antagonists have reached Phase II or Phase III clinical trials in insomnia, five of which are dual orexin receptor antagonists (DORAs) that target both OX1 and OX2 receptors (OX2Rs)...
December 2, 2016: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/27906984/balance-and-muscle-strength-in-elderly-women-who-dance-samba
#2
Marcos Maurício Serra, Angelica Castilho Alonso, Mark Peterson, Luis Mochizuki, Júlia Maria D'Andréa Greve, Luiz Eugênio Garcez-Leme
Considering the growth of the aging population, and the increasing risk for falls and related morbidity, it is vital to seek efficient, comprehensive, and culturally relevant prevention programs for elderly people to reduce risks for falls. The aim of the present study was to evaluate the postural balance and muscle strength among women participating in the "Wing of Baianas" in the carnival parades. One hundred and ten women, with an average age of 67.4±5.9 years, were divided into two groups: Baianas group-elderly participants of the carnival parades in the "Wing of Baianas", and a Control group of women who do not dance samba...
2016: PloS One
https://www.readbyqxmd.com/read/27904513/relationship-between-visual-status-and-functional-status-and-the-risk-of-falls-in-women-the-rac-ost-pol-study
#3
Wojciech Rokicki, Bogna Drozdzowska, Aleksandra Czekajło, Władysław Grzeszczak, Katarzyna Wiktor, Wojciech Majewski, Wojciech Pluskiewicz
INTRODUCTION: Falls in elderly women producing fractures are a public health problem that could be largely preventable. The aim of this study was to determine the effect of visual impairment on functional status, falls and fractures in women. MATERIAL AND METHODS: We examined 623 women aged ≥ 55 years in order to assess the association between visual status and functional status and the risk of falls and fractures. Distance, near visual acuity, and depth perception were examined...
December 1, 2016: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/27891571/high-risk-medications-in-hospitalized-elderly-adults-are-we-making-it-easy-to-do-the-wrong-thing
#4
Nina L Blachman, Rosanne M Leipzig, Madhu Mazumdar, Jashvant Poeran
OBJECTIVES: To examine dosages of high-risk medications administered to elderly adults who fall in the hospital and to determine whether electronic default doses are appropriate for elderly adults. DESIGN: Retrospective. SETTING: Large urban academic hospital. PARTICIPANTS: Individuals aged 65 and older experiencing a fall. MEASUREMENTS: Prescribed daily dosages and use of high-risk medications (opiates, benzodiazepines, benzodiazepine-receptor agonists (BRAs), sleep medications, muscle relaxants, antipsychotics) administered within 24 hours before a fall were ascertained and compared with published recommended dosages for older adults and the hospital's electronic medical record (EMR) default doses for these drugs...
November 28, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27889507/cyp2c9-genotypes-modify-benzodiazepine-related-fall-risk-original-results-from-three-studies-with-meta-analysis
#5
Annelies C Ham, Gijsbertus Ziere, Linda Broer, Karin M A Swart, Anke W Enneman, Suzanne C van Dijk, Janneke P van Wijngaarden, Nikita L van der Zwaluw, Elske M Brouwer-Brolsma, Rosalie A M Dhonukshe-Rutten, Natasja M van Schoor, M Carola Zillikens, Teun van Gelder, Oscar J de Vries, Paul Lips, Dorly J H Deeg, Lisette C P G M de Groot, Albert Hofman, Renger F Witkamp, André G Uitterlinden, Bruno H Stricker, Nathalie van der Velde
OBJECTIVE: To investigate whether the CYP2C9*2 and *3 variants modify benzodiazepine-related fall risk. DESIGN: Three prospective studies; the Rotterdam Study, B-PROOF, and LASA. SETTING: Community-dwelling individuals living in or near five Dutch cities. PARTICIPANTS: There were 11,485 participants aged ≥55 years. MEASUREMENTS: Fall incidents were recorded prospectively. Benzodiazepine use was determined using pharmacy dispensing records or interviews...
November 23, 2016: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/27885859/effect-of-8%C3%A2-months-of-whole-body-vibration-training-on-quality-of-life-in-elderly-women
#6
Fernanda Santin-Medeiros, Alejandro Santos-Lozano, Carlos Cristi-Montero, Nuria Garatachea Vallejo
Whole-body vibration (WBV) training in elderly may improve muscle strength, muscle power and postural control. However, knowledge about the effect of WBV training in elderly on measures of health as a multidimensional construct (health-related quality of life, HRQoL) is scarce. The present study aimed to determine the effects of WBV training on HRQoL in elderly women. A total of 37 women (aged 82.4 ± 5.7 years) were recruited and were assigned to either the WBV group or to the control (CON) group. After 8 months of training, the WBV group showed non-significant changes on HRQoL and additional health-related outcomes (fall risk, life satisfaction or cognitive status)...
November 25, 2016: Research in Sports Medicine
https://www.readbyqxmd.com/read/27884843/traumatic-brain-injury-in-england-and-wales-prospective-audit-of-epidemiology-complications-and-standardised-mortality
#7
T Lawrence, A Helmy, O Bouamra, M Woodford, F Lecky, P J Hutchinson
OBJECTIVES: To provide a comprehensive assessment of the management of traumatic brain injury (TBI) relating to epidemiology, complications and standardised mortality across specialist units. DESIGN: The Trauma Audit and Research Network collects data prospectively on patients suffering trauma across England and Wales. We analysed all data collected on patients with TBI between April 2014 and June 2015. SETTING: Data were collected on patients presenting to emergency departments across 187 hospitals including 26 with specialist neurosurgical services, incorporating factors previously identified in the Ps14 multivariate logistic regression (Ps14(n)) model multivariate TBI outcome prediction model...
November 24, 2016: BMJ Open
https://www.readbyqxmd.com/read/27882314/the-role-of-pharmacists-in-preventing-falls-among-america-s-older-adults
#8
Mamta V Karani, Yara Haddad, Robin Lee
Falls are the leading cause of both fatal and non-fatal injuries in people aged 65 years and older and can lead to significant costs, injuries, functional decline, and reduced quality of life. While certain medications are known to increase fall risk, medication use is a modifiable risk factor. Pharmacists have specialized training in medication management and can play an important role in fall prevention. Working in a patient-centered team-based approach, pharmacists can collaborate with the primary care providers to reduce fall risk...
2016: Frontiers in Public Health
https://www.readbyqxmd.com/read/27859762/death-wishes-among-older-people-assessed-for-home-support-and-long-term-aged-residential-care
#9
Gary Cheung, Siobhan Edwards, Frederick Sundram
OBJECTIVE: Death wishes in older people are common and may progress to suicidal ideation and attempts. This study used routinely collected data from the interRAI Home Care assessment to examine the prevalence and clinical predictors of death wishes in older New Zealanders assessed for home support and long-term aged residential care. METHODS: Data were collected from 35 734 people aged over 65 during 2012-2014. Chi-squared analyses were used to determine significant relationships between the presence of death wishes and demographic factors, health and functional status, and emotional and psychosocial well-being...
November 17, 2016: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/27853703/deciphering-pro-lymphangiogenic-programs-during-mammary-involution-and-postpartum-breast-cancer
#10
REVIEW
Virginia F Borges, Alan M Elder, Traci R Lyons
Postpartum breast cancers are a highly metastatic subset of young women's breast cancers defined as breast cancers diagnosed in the postpartum period or within 5 years of last child birth. Women diagnosed with postpartum breast cancer are nearly twice as likely to develop metastasis and to die from breast cancer when compared with nulliparous women. Additionally, epidemiological studies utilizing multiple cohorts also suggest that nearly half of all breast cancers in women aged <45 qualify as postpartum cases...
2016: Frontiers in Oncology
https://www.readbyqxmd.com/read/27845703/older-swedish-adults-with-high-self-perceived-health-show-optimal-25-hydroxyvitamin-d-levels-whereas-vitamin-d-status-is-low-in-patients-with-high-disease-burden
#11
Martin Carlsson, Pär Wanby, Lars Brudin, Erik Lexne, Karin Mathold, Rebecca Nobin, Lisa Ericson, Ola Nordqvist, Göran Petersson
Controversy pervades the definition of adequate and optimal vitamin D status. The Institutes of Medicine have recommended serum 25(OH)D levels above 50 nmol/L based upon evidence related to bone health, but some experts, including the Endocrine Society and International Osteoporosis Foundation, suggest a minimum serum 25(OH)D level of 75 nmol/L to reduce the risk of falls and fractures in older adults. In a cross-sectional study, we compared vitamin D status in people ≥75 years selected from four groups with a frailty phenotype, combined with a control group free from serious illness, and who considered themselves completely healthy...
November 11, 2016: Nutrients
https://www.readbyqxmd.com/read/27844133/gait-speed-and-one-leg-standing-time-each-add-to-the-predictive-ability-of-frax
#12
H Lundin, M Sääf, L-E Strender, S Nyren, S-E Johansson, H Salminen
: Gait speed or one-leg standing time (OLST) as additional predictors in FRAX. Population 351 elderly women followed 10 years. Both could improve predictions. The area under curve (AUC) for FRAX is 0.59, OLST is 0.69 and gait speed is 0.71. The net reclassification index (NRI) for classification to highest risk quartile or lowest three quartiles was 0.24 for gait speed and non-significant for OLST. INTRODUCTION: The risk of falls and bone strength are two main determinants of hip fracture risk...
November 14, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27832209/handgrip-strength-and-factors-associated-in-poor-elderly-assisted-at-a-primary-care-unit-in-rio-de-janeiro-brazil
#13
Valéria Teresa Saraiva Lino, Nádia Cristina Pinheiro Rodrigues, Gisele O'Dwyer, Mônica Kramer de Noronha Andrade, Inês Echenique Mattos, Margareth Crisóstomo Portela
INTRODUCTION: Sarcopenia is a condition diagnosed when the patient presents low muscle mass, plus low muscle strength or low physical performance. Muscle weakness in the oldest (dynapenia) is a major public health concern because it predicts future all-cause mortality and is associated with falls, disability, cardiovascular mortality and morbidity. Grip strength is a simple method for assessment of muscle function in clinical practice. OBJECTIVE: To estimate the grip strength and identify factors associated with handgrip strength variation in elderly people with low socioeconomic status...
2016: PloS One
https://www.readbyqxmd.com/read/27828582/-factors-associated-with-the-frailty-of-elderly-people-with-chronic-kidney-disease-on-hemodialysis
#14
Gabriela Dutra Gesualdo, Marisa Silvana Zazzetta, Karina Gramani Say, Fabiana de Souza Orlandi
The scope of this article is to identify sociodemographic and clinical factors associated with the frailty of elderly people with chronic kidney disease on hemodialysis. This involved a correlational, cross-sectional study conducted in a dialysis center in the state of São Paulo. The sample consisted of 60 participants. The Participant Characterization Instrument was used for extracting sociodemographic and clinical data and the Edmonton Frail Scale was used to evaluate the level of frailty. Multivariate logistic regression was used to identify the factors associated with frailty...
November 2016: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/27825536/are-falls-prevention-programs-effective-at-reducing-the-risk-factors-for-falls-in-people-with-type-2-diabetes-mellitus-and-peripheral-neuropathy-a-systematic-review-with-narrative-synthesis
#15
REVIEW
Yu Gu, Sarah M Dennis
BACKGROUND: Diabetic peripheral neuropathy (DPN) is a common complication of type-2 diabetes mellitus (T2DM) that predisposes the elderly to a higher falls risk. Falls prevention programs with a component of weight-bearing exercises are effective in decreasing future falls in the elderly. However, weight-bearing exercise was only recently recommended in guidelines for exercise for people with T2DM and DPN. Since then, there have been an increasing number of studies to evaluate the effectiveness of falls prevention programs on this targeted population...
October 8, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27823938/are-triage-questions-sufficient-to-assign-fall-risk-precautions-in-the-ed
#16
Lauren T Southerland, Lauren Slattery, Joseph A Rosenthal, Deborah Kegelmeyer, Anne Kloos
OBJECTIVES: The American College of Emergency Physicians Geriatric Emergency Department (ED) Guidelines and the Center for Disease Control recommend that older adults be assessed for risk of falls. The standard ED assessment is a verbal query of fall risk factors, which may be inadequate. We hypothesized that the addition of a functional balance test endorsed by the Center for Disease Control Stop Elderly Accidents, Deaths, and Injuries Falls Prevention Guidelines, the 4-Stage Balance Test (4SBT), would improve the detection of patients at risk for falls...
October 17, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27823737/a-one-year-proprioceptive-exercise-programme-reduces-the-incidence-of-falls-in-community-dwelling-elderly-people-a-before-after-non-randomised-intervention-study
#17
Pilar Pérez-Ros, Francisco M Martinez-Arnau, Vincenzo Malafarina, Francisco J Tarazona-Santabalbina
BACKGROUND: The risk of falls increases with age. Balance alteration and polypharmacy are independent contributors to an increased risk of falls. OBJECTIVE: The primary aim was to assess whether a proprioceptive exercise programme reduces the incidence of falls. A secondary aim was to assess the association between drugs and falls. DESIGN: This was a before-after non-randomised intervention study. PARTICIPANTS: The study recruited independent and cognitively intact community-dwelling people aged over 69 years, from December 2012 to May 2014...
December 2016: Maturitas
https://www.readbyqxmd.com/read/27820555/sarcopenia-as-a-predictor-of-mortality-in-elderly-blunt-trauma-patients-comparing-the-masseter-to-the-psoas-using-computed-tomography
#18
James D Wallace, Richard Y Calvo, Paul R Lewis, Jason B Brill, Steven R Shackford, Michael J Sise, C Beth Sise, Vishal Bansal
BACKGROUND: Sarcopenia, or age-related loss of muscle mass, is measureable by computed tomography (CT). In elderly trauma patients, increased mortality is associated with decreased psoas muscle cross-sectional area (P-Area) on abdominal CT. Fall is the leading cause of injury in the elderly and head CT is more often obtained. Masseter muscle cross-sectional area (M-Area) is readily measured on head CT. Hypothesizing that M-Area is a satisfactory surrogate for P-Area, we compared the two as markers of sarcopenia and increased mortality in elderly trauma patients...
November 4, 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/27816860/unsupervised-boundary-delineation-of-spinal-neural-foramina-using-a-multi-feature-and-adaptive-spectral-segmentation
#19
Xiaoxu He, Heye Zhang, Mark Landis, Manas Sharma, James Warrington, Shuo Li
As a common disease in the elderly, neural foramina stenosis (NFS) brings a significantly negative impact on the quality of life due to its symptoms including pain, disability, fall risk and depression. Accurate boundary delineation is essential to the clinical diagnosis and treatment of NFS. However, existing clinical routine is extremely tedious and inefficient due to the requirement of physicians' intensively manual delineation. Automated delineation is highly needed but faces big challenges from the complexity and variability in neural foramina images...
October 29, 2016: Medical Image Analysis
https://www.readbyqxmd.com/read/27813488/-epidemiology-of-spinal-cord-injury-in-iceland-from-1975-to-2014
#20
Eyrún Arna Kristinsdottir, Sigrun Knutsdottir, Kristinn Sigvaldason, Halldor Jonsson, Pall E Ingvarsson
INTRODUCTION: Traumatic spinal cord injury (TSCI) is serious and often has long-term consequences. Since no cure has been found the emphasis has been on preventive measures. The incidence of TSCI varies between countries and the epidemiology has been changing. The aim of this study was to gather epidemiological data on patients with TSCI in Iceland and search for risk factors. MATERIAL AND METHODS: Hospital records of everyone diagnosed with TSCI in 1975-2014 admitted to Landspitali University Hospital were reviewed and information gathered on incidence, age, gender and causes of injury...
November 2016: Læknablađiđ
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