keyword
https://read.qxmd.com/read/38531476/the-impact-of-embedment-of-the-side-arms-of-52-mg-levonorgestrel-intrauterine-device-on-bleeding-and-pain-a-prospective-cohort-study
#1
JOURNAL ARTICLE
P A H H van der Heijden, M Y Bongers, S Veersema, J P Dieleman, P M A J Geomini
PURPOSE: The purpose of this study was to analyse the impact of embedment of side arms of the levonorgestrel 52 mg intrauterine device (LNG-IUD) in the myometrium (assessed by three-dimensional transvaginal ultrasound (3D-TVUS)) on uterine bleeding and pain. MATERIALS AND METHODS: We performed a prospective cohort study in a large Dutch teaching hospital between February 2015 and December 2016. Participants over 18 years of age who selected a LNG-IUD for contraception or because of heavy menstrual bleeding were eligible for inclusion...
March 24, 2024: Journal of Gynecology Obstetrics and Human Reproduction
https://read.qxmd.com/read/38520881/treatment-outcomes-according-to-various-progestin-treatment-strategies-in-patients-with-atypical-hyperplasia-endometrial-intraepithelial-neoplasia-multicenter-retrospective-study-kgog2033
#2
JOURNAL ARTICLE
Nam Kyeong Kim, Chel Hun Choi, Seok Ju Seong, Jong-Min Lee, Banghyun Lee, Kidong Kim
OBJECTIVE: To investigate pathologic complete response (pCR) and recurrence outcomes using various progestin treatment strategies in patients with atypical hyperplasia/endometrial intraepithelial neoplasia (AH/EIN). METHODS: Medical records of patients diagnosed with AH/EIN and undergoing follow-up endometrial biopsy after progestin treatment between 2011 and 2020 were retrospectively reviewed. Clinical factors and treatment outcomes were analyzed according to initial progestin treatment (oral progestin [OP], levonorgestrel-releasing intrauterine device [LNG-IUD], and combination), OP dose, and maintenance treatment using Pearson's χ2 , Fisher's exact test, and Kaplan-Meier analysis...
March 22, 2024: Gynecologic Oncology
https://read.qxmd.com/read/38476740/depression-risk-in-users-of-different-doses-of-levonorgestrel-intrauterine-systems-a-nationwide-prospective-cohort-study
#3
JOURNAL ARTICLE
Charlotte Wessel Skovlund, Amalie Lykkemark Møller, Christian Torp-Pedersen, Lina Steinrud Mørch, Amani Meaidi
BACKGROUND: Use of the high-dose levonorgestrel-releasing intrauterine system (LNG-IUS) has been associated with increased risk of incident depression. Evidence is lacking on the influence of use of two recently marketed low-dose LNG-IUS on risk of depression. This study aims to examine associations between use of different doses of LNG-IUS and risk of depression. METHODS: We conducted a nationwide prospective cohort study involving all first-time users of an LNG-IUS among all Danish nulliparous women aged 15-34 years with no medical history of depression, major psychiatric diseases, endometriosis, heavy menstrual bleeding, polyp, myoma, dysmenorrhoea, iron supplement use, abortion, and infertility treatment...
March 2024: The Lancet regional health. Europe
https://read.qxmd.com/read/38462038/body-mass-index-and-levonorgestrel-device-expulsion-in-adolescents-and-young-adults
#4
JOURNAL ARTICLE
Megan Masten, Heami Yi, Laurel Beaty, Kendra Hutchens, Veronica Alaniz, Eliza Buyers, Jaime M Moore
OBJECTIVE: To evaluate the relationship between body mass and levonorgestrel intrauterine device (LNG-IUD) expulsion in adolescents and young adults (AYA). METHODS: A retrospective chart review was conducted of nulliparous females aged 10-24 years who had a 52-milligram LNG-IUD placed between November 2017-May 2021 by pediatric and adolescent gynecology providers at a tertiary children's hospital, including those who underwent metabolic and bariatric surgery (MBS)...
March 8, 2024: Journal of Pediatric and Adolescent Gynecology
https://read.qxmd.com/read/38459552/effects-of-depot-medroxyprogesterone-acetate-the-copper-iud-and-the-levonorgestrel-implant-on-testosterone-sex-hormone-binding-globulin-and-free-testosterone-levels-ancillary-study-of-the-echo-randomized-clinical-trial
#5
JOURNAL ARTICLE
G Justus Hofmeyr, Mandisa Singata-Madliki, Joanne Batting, Yusentha Balakrishna, Chelsea Morroni
BACKGROUND: Robust information on relative effects of hormonal contraceptives on endogenous androgens is important for understanding beneficial and adverse effects, method choice and development of new methods. METHODS: In this ancillary study at the East London, South Africa site of the ECHO multicentre randomized trial, we compared effects of three contraceptive methods on serum androgen levels among contraceptive users aged 18 to 35 years. Participants were allocated by centrally-managed randomization to open label depot medroxyprogesterone acetate (DMPA-IM), copper intrauterine device (IUD) or levonorgestrel implant...
March 8, 2024: BMC Women's Health
https://read.qxmd.com/read/38440962/is-there-a-difference-in-the-clinical-profile-and-outcome-of-women-using-levonorgestrel-iud-for-abnormal-uterine-bleeding-and-those-using-it-for-contraception-a-comparative-cross-sectional-study
#6
JOURNAL ARTICLE
Maryam Al Shukri, Maryam Said, Asha Nair, Mariam Mathew, Vaidyanatahn Gowri
OBJECTIVE: The most common indications for Levonorgestrel intrauterine device (LNG-IUD) are contraception and management of abnormal uterine bleeding (AUB). This study was conducted with the aim of exploring the differences in the clinical profile and outcome of women using LNG-IUD for contraception and AUB. MATERIALS AND METHODS: This was a retrospective comparative cross-sectional study of women who underwent LNG-IUD (52 mg) between 2012 and 2017. Their electronic health records were reviewed until the last documented follow-up or until December 2021...
March 4, 2024: Turkish Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/38425141/the-efficacy-of-the-levonorgestrel-intrauterine-system-versus-oral-megestrol-acetate-in-treating-atypical-endometrial-hyperplasia-a-superior-randomized-controlled-trial
#7
JOURNAL ARTICLE
Amr A Alnemr, Ola A Harb, Hytham Atia
OBJECTIVE: To compare the efficacy of the levonorgestrel intrauterine system (LNG-IUS) versus megestrol acetate (MA) in inducing complete regression among women with atypical endometrial hyperplasia (AEH) who declined hysterectomy. METHODS: In this single-center, open-label randomized controlled trial, we included 148 women with AEH who declined hysterectomy. We randomized participants to receive either daily oral MA 160 mg (n=74) or apply LNG-IUS (n=74) and scheduled their follow-up by endometrial sampling at 3, 6, 9, 12, 18, and 24 months...
February 22, 2024: Journal of Gynecologic Oncology
https://read.qxmd.com/read/38393800/abnormal-uterine-bleeding-associated-with-hormonal-contraception
#8
JOURNAL ARTICLE
Sarina Schrager, Kelita Fox, Rachel Lee
Abnormal uterine bleeding is a common and bothersome symptom in people using hormonal contraception, and it can lead to discontinuation of reliable methods of contraception and unintended pregnancies. Clinicians should counsel individuals about the potential for abnormal bleeding at initiation of the contraceptive method. After considering and excluding other potential causes of abnormal uterine bleeding, clinicians can offer treatment options specific to each hormonal contraceptive method. This article includes algorithms to help clinicians treat abnormal uterine bleeding in people using levonorgestrel intrauterine devices, depo-medroxyprogesterone acetate, progestin implant, progestin-only pills, and combined hormonal contraception...
February 2024: American Family Physician
https://read.qxmd.com/read/38327760/sexual-and-reproductive-health-and-rights-of-migrant-women-attending-primary-care-in-england-a-population-based-cohort-study-of-1-2-million-individuals-of-reproductive-age-2009-2018
#9
JOURNAL ARTICLE
Neha Pathak, Claire X Zhang, Yamina Boukari, Rachel Burns, Dee Menezes, Gregory Hugenholtz, Rebecca S French, Arturo Gonzalez-Izquierdo, Rohini Mathur, Spiros Denaxas, Andrew Hayward, Pam Sonnenberg, Robert W Aldridge
BACKGROUND: Evidence on the sexual and reproductive health and rights (SRHR) of migrants is lacking globally. We describe SRHR healthcare resource use and long-acting reversible contraceptives (LARCs) prescriptions for migrant versus non-migrant women attending primary care in England (2009-2018). METHODS: This population-based observational cohort study, using Clinical Practice Research Datalink (CPRD) GOLD, included females living in England aged 15 to 49. Migration was defined using a validated codelist...
2024: Journal of migration and health
https://read.qxmd.com/read/38305500/levonorgestrel-releasing-intrauterine-device-therapy-versus-oral-progestin-treatment-for-reproductive-aged-patients-with-endometrial-intraepithelial-neoplasia-a-systematic-review-and-meta-analysis
#10
JOURNAL ARTICLE
Yukio Suzuki, Jennifer S Ferris, Ling Chen, Shayan Dioun, John Usseglio, Koji Matsuo, Xiao Xu, Dawn L Hershman, Jason D Wright
BACKGROUND: We conducted a systematic review and meta-analysis to examine outcomes of patients with endometrial intraepithelial neoplasia (EIN) treated with oral progestins or levonorgestrel-releasing intrauterine device (LNG-IUD). METHODS: We conducted a systematic review across five databases to examine outcomes of progestational treatment (oral progestins or LNG-IUD) for patients with EIN. The primary outcome was the best complete response (CR) rate within twelve months of primary progestational treatment...
February 1, 2024: Journal of the National Cancer Institute
https://read.qxmd.com/read/38299835/gene-expression-associated-with-vaginal-bleeding-in-women-using-the-52-mg-levonorgestrel-hormonal-intrauterine-device-a-prospective-study
#11
JOURNAL ARTICLE
Flávia R Torelli, Raquel M Rodrigues-Peres, Iscia Lopes-Cendes, Luis Bahamondes, Cássia R T Juliato
OBJECTIVE: To evaluate gene expression associated with vaginal bleeding in the 52-mg hormonal intrauterine device (IUD) users. MATERIALS AND METHODS: We conducted a prospective study involving 100 women seeking to use the 52-mg hormonal IUD for contraception. We excluded women with a history or current condition of abnormal uterine bleeding and who were unable to attend a 1-year follow up. Women who expelled the device, removed it for reasons unrelated to vaginal bleeding, or were lost to follow up were discontinued...
February 1, 2024: International Journal of Gynaecology and Obstetrics
https://read.qxmd.com/read/38280433/a-52-mg-levonorgestrel-releasing-intrauterine-system-versus-bipolar-radiofrequency-non-resectoscopic-endometrial-ablation-in-women-with-heavy-menstrual-bleeding-long-term-follow-up-of-a-multi-center-randomized-controlled-trial
#12
JOURNAL ARTICLE
Daniëlle P C Huijs, Arianne J M Derickx, Pleun Beelen, Jaklien C Leemans, Sander M J Van Kuijk, Marlies Y Bongers, Peggy M A J Geomini
BACKGROUND: The symptom of heavy menstrual bleeding has a significant impact on professional, physical and social functioning. In 2021, results from a randomized controlled trial comparing a 52 mg levonorgestrel-releasing intrauterine system and radiofrequency non-resectoscopic endometrial ablation as treatments for women with heavy menstrual bleeding were published. Both treatment strategies were equally effective in treating heavy menstrual bleeding during a two-year follow-up. However, long-term results are also relevant for both patients and health care providers...
January 25, 2024: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/38241970/the-levonorgestrel-releasing-intrauterine-device-is-related-to-early-emotional-reactivity-an-erp-study
#13
JOURNAL ARTICLE
Ingrida Zelionkaitė, Rimantė Gaižauskaitė, Helen Uusberg, Andero Uusberg, Aistė Ambrasė, Birgit Derntl, Ramunė Grikšienė
Despite the evidence of altered emotion processing in oral contraceptive (OC) users, the impact of hormonal intrauterine devices (IUD) on emotional processing remains unexplored. Our study aimed to investigate how behavioural performance and event-related potentials (ERPs) linked with emotion reactivity and its regulation are associated with hormonal profiles of women using different types of hormonal contraception and naturally cycling women. Women using OCs (n = 25), hormonal IUDs (n = 33), and naturally cycling women in their early follicular (NCF, n = 33) or mid-luteal (NCL, n = 28) phase of the menstrual cycle were instructed to view emotional pictures (neutral, low and high negativity) and use cognitive reappraisal to up- or down-regulate negative emotions, while their electroencephalogram was recorded...
January 12, 2024: Psychoneuroendocrinology
https://read.qxmd.com/read/38241742/block-scheduling-for-larc-in-a-family-medicine-residency-program
#14
JOURNAL ARTICLE
Elisabeth F Callen, Rahmat Na'Allah, Artis Lewis, James Kerns, Christina M Hester
BACKGROUND AND OBJECTIVES: Only 20% of family physicians report providing long-acting reversible contraception (LARC). Clinician-related barriers include confidence and comfort with LARC counseling and insertion/removal, and limited availability and uptake. Training during residency may address barriers and increase access/availability of LARC to support reproductive autonomy. We sought to determine the impact of block scheduling LARC clinics on resident comfort and confidence with LARC counseling and insertion/removal...
December 20, 2023: Family Medicine
https://read.qxmd.com/read/38232939/health-related-quality-of-life-and-satisfaction-associated-with-three-year-use-of-a-levonorgestrel-13-5-mg-intrauterine-device-versus-nova-t-copper-380-mm-2-intrauterine-device-results-of-a-phase-4-randomized-controlled-trial
#15
JOURNAL ARTICLE
Josep Perelló-Capó, Josep Estadella-Tarriel, Ignasi Gich-Saladich, Marta Bailón-Queiruga, Elisa Llurba-Olivé, Joaquim Calaf-Alsina
OBJECTIVE: To investigate the impact of levonorgestrel 13.5 mg- and Nova T copper 380 mm2 intrauterine devices (LNG13.5-IUD and Cu380-IUD, respectively) on health-related quality of life (HRQoL) and the satisfaction with the method throughout three years of use. STUDY DESIGN: We conducted a single-center, evaluator-masked, randomized controlled trial to compare the bleeding profile of LNG13.5-IUD and Cu380-IUD users. HRQoL and satisfaction at months 12, 24, and 36 were secondary objectives...
January 15, 2024: Contraception
https://read.qxmd.com/read/38216133/efficacy-of-fertility-sparing-treatment-with-lng-ius-is-associated-with-different-promise-subtypes-of-endometrial-carcinoma-or-atypical-endometrial-hyperplasia
#16
JOURNAL ARTICLE
Xiaofeng Lv, Lili Guo, Changyu Wang
OBJECTIVE: To determine whether proactive molecular risk classifier for endometrial cancer (ProMisE) could be used to assess the prognosis of patients with atypical endometrial hyperplasia (AEH) or early-stage endometrial cancer (EC) treated with levonorgestrel-releasing intrauterine system (LNG-IUS). METHODS: A retrospective cohort study was conducted among 93 AEH or early-stage EC patients who received LNG-IUS to preserve fertility . By immunohistochemistry and gene sequencing, 4 subtypes of ProMisE were identified (p53 wild type [p53 wt], mismatch repair-deficient [MMRd], p53-abnormal, and POLE-mutated)...
December 18, 2023: Journal of Gynecologic Oncology
https://read.qxmd.com/read/38195047/uptake-discontinuation-and-continuation-rate-of-long-acting-contraceptive-methods-larc-when-offered-at-no-cost-in-campinas-brazil
#17
JOURNAL ARTICLE
Montas Laporte, Ana C Marcelino, Paula da Cunha Pereira, Ximena Espejo-Arce, Cassia T Juliato, Luis Bahamondes
OBJECTIVE: To compare the uptake, reasons for discontinuation, continuation, and satisfaction of long-acting contraceptive methods (LARC) when offered at no cost in Campinas, Brazil. METHODS: A prospective cohort study conducted at University of Campinas, Campinas, SP, Brazil, including women aged 18-43 years, who adopted one of three methods. Participants underwent telephone follow-up every three months for up to 24 months after insertion. Satisfaction was assessed at the end of two years of use through the Likert scale...
January 7, 2024: Contraception
https://read.qxmd.com/read/38191409/laparoscopic-adenomyomectomy-combined-with-levonorgestrel-releasing-intrauterine-system-is-effective-for-long-term-management-of-adenomyosis
#18
JOURNAL ARTICLE
Jilan Jiang, Yilian Pan, Jin Yu, Ye Zhang, Yeping Yang, Hong Xu, Feng Sun
BACKGROUD: Laparoscopic adenomyomectomy combined with intraoperative placement of levonorgestrel-releasing intrauterine device (LNG-IUS) is a novel conservative surgical procedure for adenomyosis. Our study aimed to compare the efficacy of surgery with or without intraoperative placement of LNG-IUS treatment in adenomyosis. METHODS: We retrospectively reviewed the medical records of adenomyosis patients who received laparoscopic adenomyomectomy from January 2014 to April 2020, finally including 70 patients undergoing surgery-LNG-IUS as group A and 69 patients undegoing surgery only as group B...
January 8, 2024: BMC Women's Health
https://read.qxmd.com/read/38190866/longitudinal-impact-of-a-residency-based-postplacental-levonorgestrel-intrauterine-device-insertion-program-expulsion-rates-in-years-1-2-and-3
#19
JOURNAL ARTICLE
Leanne L Free, Benjamin P Brown, Kristen A Matteson, Beth Cronin, Phinnara Has, Victoria Zeyl, Rebecca H Allen
OBJECTIVES: To evaluate expulsion rates in the first three years of an academic postplacental levonorgestrel intrauterine device (LNG-IUD) insertion program. STUDY DESIGN: Retrospective case series, January, 2016-December, 2018. We measured LNG-IUD expulsion rates by 12 weeks postpartum. RESULTS: Of 235 LNG-IUD insertions, in years 1, 2, and 3, expulsion rates were 11/39 (28%), 9/94 (10%), and 15/102 (15%) (p=0.03). After vaginal delivery, manual insertion was associated with a higher expulsion rate than ring-forceps (10/28 [36%] vs...
January 6, 2024: Contraception
https://read.qxmd.com/read/38160328/intrauterine-devices-are-a-safe-form-of-contraception-in-users-with-solid-organ-transplantation-a-single-center-experience
#20
JOURNAL ARTICLE
Stephanie I Amaya, Sharon F Wolff, Meghan Ross, Valerie A French
Patients who undergo organ transplantation are advised to use contraception for health optimization, yet limited data exists on safe contraceptive options for this population. This study investigates the infection risk of intrauterine devices (IUDs) in patients who have received a solid organ transplant by evaluating the incidence of pelvic inflammatory disease (PID). We performed a retrospective chart review of subjects with a solid organ transplant who used an IUD between the years of January 2007 to February 2021...
December 31, 2023: Transplant Infectious Disease: An Official Journal of the Transplantation Society
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