Tom G Keulers, Alexander Koch, Marike W van Gisbergen, Lydie M O Barbeau, Marijke I Zonneveld, Monique C de Jong, Kim G M Savelkouls, Roel G Wanders, Johan Bussink, Veerle Melotte, Kasper M A Rouschop
Hypoxia is a common feature of solid tumors and is associated with increased tumor progression, resistance to therapy and increased metastasis. Hence, tumor hypoxia is a prognostic factor independent of treatment modality. To survive hypoxia, cells activate macroautophagy/autophagy. Paradoxically, in several cancer types, mutations or loss of essential autophagy genes have been reported that are associated with earlier onset of tumor growth. However, to our knowledge, the phenotypic and therapeutic consequences of autophagy deficiency have remained unexplored...
December 14, 2021: Autophagy