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Hypoxia and HNSCC

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https://www.readbyqxmd.com/read/27919941/ectopic-myoglobin-expression-is-associated-with-a-favourable-outcome-in-head-and-neck-squamous-cell-carcinoma-patients
#1
Sebastian Meller, Anne VAN Ellen, Heidrun Gevensleben, Anne Bicker, Thomas Hankeln, Thomas A Gorr, Verena Sailer, Freya Dröge, Friederike Schröck, Friedrich Bootz, Andreas Schröck, Sven Perner, Dimo Dietrich, Glen Kristiansen
BACKGROUND/AIM: Ectopic myoglobin (MB) expression, mediated by alternative and hypoxia-inducible transcription, has recently been demonstrated in several epithelial tumours. This study aimed to examine the expression of MB in hormone-independent head and neck squamous cell carcinomas (HNSCCs). PATIENTS AND METHODS: Using imunohistochemistry, ectopic MB expression was analyzed on tissue microarrays (TMAs) of 524 patients with localized and locally advanced primary and recurrent HNSCC who had undergone surgical treatment with curative intent...
December 2016: Anticancer Research
https://www.readbyqxmd.com/read/27913065/hpv-status-cancer-stem-cell-marker-expression-hypoxia-gene-signatures-and-tumour-volume-identify-good-prognosis-subgroups-in-patients-with-hnscc-after-primary-radiochemotherapy-a-multicentre-retrospective-study-of-the-german-cancer-consortium-radiation-oncology
#2
Annett Linge, Fabian Lohaus, Steffen Löck, Alexander Nowak, Volker Gudziol, Chiara Valentini, Cläre von Neubeck, Martin Jütz, Inge Tinhofer, Volker Budach, Ali Sak, Martin Stuschke, Panagiotis Balermpas, Claus Rödel, Anca-Ligia Grosu, Amir Abdollahi, Jürgen Debus, Ute Ganswindt, Claus Belka, Steffi Pigorsch, Stephanie E Combs, David Mönnich, Daniel Zips, Frank Buchholz, Daniela E Aust, Gustavo B Baretton, Howard D Thames, Anna Dubrovska, Jan Alsner, Jens Overgaard, Mechthild Krause, Michael Baumann
OBJECTIVE: To investigate the impact of the tumour volume, HPV status, cancer stem cell (CSC) marker expression and hypoxia gene signatures, as potential markers of radiobiological mechanisms of radioresistance, in a contemporary cohort of patients with locally advanced head and neck squamous cell carcinoma (HNSCC), who received primary radiochemotherapy (RCTx). MATERIALS AND METHODS: For 158 patients with locally advanced HNSCC of the oral cavity, oropharynx or hypopharynx who were treated at six DKTK partner sites, the impact of tumour volume, HPV DNA, p16 overexpression, p53 expression, CSC marker expression and hypoxia-associated gene signatures on outcome of primary RCTx was retrospectively analyzed...
November 29, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27884018/blood-transfusion-during-radical-chemo-radiotherapy-does-not-reduce-tumour-hypoxia-in-squamous-cell-cancer-of-the-head-and-neck
#3
Liam Welsh, Rafal Panek, Angela Riddell, Kee Wong, Martin O Leach, Mahvash Tavassoli, Durdana Rahman, Maria Schmidt, Tara Hurley, Lorna Grove, Thomas Richards, Dow-Mu Koh, Christopher Nutting, Kevin Harrington, Kate Newbold, Shreerang Bhide
BACKGROUND: Patients with head and neck squamous cell carcinoma (HNSCC) undergoing radical chemo-radiation (CRT) frequently receive transfusion with packed red cells (PRCT) during radiotherapy on the basis that PRCT increases tumour oxygenation and overcomes hypoxia-induced radio-resistance. This is likely to be a significant oversimplification given the fact that tumour hypoxia is the result of several intrinsic and extrinsic factors, including many that are not directly related to serum haemoglobin (Hb)...
November 24, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27802455/downregulation-of-egfr-in-hypoxic-diffusion-limited-areas-of-squamous-cell-carcinomas-of-the-head-and-neck
#4
Arnulf Mayer, Sebastian Zahnreich, Jürgen Brieger, Peter Vaupel, Heinz Schmidberger
BACKGROUND: The receptor for the epidermal growth factor (EGFR) is widely considered to be one of the central drivers of oncogenesis in squamous cell carcinomas of the head and neck region (HNSCC). Inhibition of EGFR using monoclonal antibodies is established both in the curative and the palliative setting in this disease. HNSCCs are known to contain abundant hypoxic tissue areas and hypoxia has been shown to be involved in the (down)regulation of EGFR membrane expression. METHODS: A novel method for multiplex immunofluorescence and single-cell segmentation (via DAPI-stained nuclei) was established, to study the expression of EGFR, the endogenous hypoxia marker CA IX, and intratumoural diffusion distances from microvessels (using CD34 staining) in 58 human HNSCCs and 9 normal/cancer adjacent tissues...
November 22, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27791989/stimulation-of-the-toll-like-receptor-3-promotes-metabolic-reprogramming-in-head-and-neck-carcinoma-cells
#5
Mathieu Veyrat, Sylvère Durand, Marion Classe, Tanja Matijevic Glavan, Natalie Oker, Nikiforos-Ioannis Kapetanakis, Xiaojun Jiang, Aurore Gelin, Philippe Herman, Odile Casiraghi, David Zagzag, David Enot, Pierre Busson, Benjamin Vérillaud
In this study, a possible link between the innate immune recognition receptor TLR3 and metabolic reprogramming in Head and Neck carcinoma (HNC) cells was investigated. The effects of TLR3 stimulation/knock-down were assessed under several culture conditions in 4 HNC cell-lines by cell growth assays, targeted metabolomics, and glycolysis assays based on time-resolved analysis of proton release (Seahorse analyzer). The stimulation of TLR3 by its synthetic agonist Poly(A:U) resulted in a faster growth of HNC cells under low foetal calf serum conditions...
October 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27788497/macrophage-migration-inhibitory-factor-a-potential-driver-and-biomarker-for-head-and-neck-squamous-cell-carcinoma
#6
REVIEW
Sha-Sha Wang, Xiao Cen, Xin-Hua Liang, Ya-Ling Tang
Macrophage migration inhibitory factor (MIF), a pleiotropic proinflammatory cytokine, has been showed to be associated with the immunopathogenesis of many diseases. Recent study demonstrated that MIF promoted tumorigenesis and tumor progression and played a critical role in various kinds of human cancer including head and neck squamous cell carcinoma(HNSCC). Hence, in this paper we retrospected the relationship between MIF and angiogenesis, epithelial-mesenchymal transition (EMT), inflammation, immune response, hypoxia microenvironment, and discussed whether it is a promising biomarker for diagnosis and supervisor of HNSCC...
October 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27370131/correlation-of-fmiso-simulations-with-pimonidazole-stained-tumor-xenografts-a-question-of-o2-consumption
#7
L J Wack, D Mönnich, A Yaromina, D Zips, M Baumann, D Thorwarth
PURPOSE: To compare a dedicated simulation model for hypoxia PET against tumor microsections stained for different parameters of the tumor microenvironment. The model can readily be adapted to a variety of conditions, such as different human head and neck squamous cell carcinoma (HNSCC) xenograft tumors. METHODS: Nine different HNSCC tumor models were transplanted subcutaneously into nude mice. Tumors were excised and immunoflourescently labeled with pimonidazole, Hoechst 33342, and CD31, providing information on hypoxia, perfusion, and vessel distribution, respectively...
July 2016: Medical Physics
https://www.readbyqxmd.com/read/27251643/evaluation-of-tumour-hypoxia-during-radiotherapy-using-18-f-hx4-pet-imaging-and-blood-biomarkers-in-patients-with-head-and-neck-cancer
#8
Catharina M L Zegers, Frank J P Hoebers, Wouter van Elmpt, Judith A Bons, Michel C Öllers, Esther G C Troost, Daniëlle Eekers, Leo Balmaekers, Marlies Arts-Pechtold, Felix M Mottaghy, Philippe Lambin
BACKGROUND AND PURPOSE: Increased tumour hypoxia is associated with a worse overall survival in patients with head and neck squamous cell carcinoma (HNSCC). The aims of this study were to evaluate treatment-associated changes in [(18)F]HX4-PET, hypoxia-related blood biomarkers, and their interdependence. MATERIAL AND METHODS: [(18)F]HX4-PET/CT scans of 20 patients with HNSCC were acquired at baseline and after ±20Gy of radiotherapy. Within the gross-tumour-volumes (GTV; primary and lymph nodes), mean and maximum standardized uptake values, the hypoxic fraction (HF) and volume (HV) were calculated...
November 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27161763/validation-of-a-15-gene-hypoxia-classifier-in-head-and-neck-cancer-for-prospective-use-in-clinical-trials
#9
Kasper Toustrup, Brita Singers Sørensen, Mohamed A Hassan Metwally, Trine Tramm, Lise Saksø Mortensen, Jens Overgaard, Jan Alsner
BACKGROUND: In head and neck squamous cell carcinomas (HNSCC) hypoxic radioresistance can be reduced by use of the hypoxic modifier nimorazole, as shown in the DAHANCA 5 trial. Recently, a 15-gene hypoxia classifier has shown predictive impact for the effect of nimorazole by identifying 'more' and 'less' hypoxic tumors in the DAHANCA 5 cohort. A prospective multicentre EORTC-1219 study is initiated, where nimorazole and prospective use of the classifier as a predictor is tested in relation to the most recent accelerated chemoradiotherapy treatment...
May 10, 2016: Acta Oncologica
https://www.readbyqxmd.com/read/27052795/biological-features-of-human-papillomavirus-related-head-and-neck-cancers-contributing-to-improved-response
#10
C Cleary, J E Leeman, D S Higginson, N Katabi, E Sherman, L Morris, S McBride, N Lee, N Riaz
Head and neck squamous cell carcinomas (HNSCC) are the sixth most common malignancy globally, and an increasing proportion of oropharyngeal HNSCCs are associated with the human papillomavirus (HPV). Patients with HPV-associated tumours have markedly improved overall and disease-specific survival compared with their HPV-negative counterparts when treated with chemoradiation. Although the difference in outcomes between these two groups is clearly established, the mechanism underlying these differences remains an area of investigation...
July 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/27036044/dysregulation-of-junctional-adhesion-molecule-a-via-p63-gata-3-in-head-and-neck-squamous-cell-carcinoma
#11
Takuya Kakuki, Makoto Kurose, Ken-Ichi Takano, Atsushi Kondoh, Kazufumi Obata, Kazuaki Nomura, Ryo Miyata, Yakuto Kaneko, Takumi Konno, Syunta Takahashi, Tsubasa Hatakeyama, Takayuki Kohno, Tetsuo Himi, Takashi Kojima
Junctional adhesion molecule-A (JAM-A), which belongs to the IgG superfamily, is a tight junction molecule associated with epithelial and endothelial barrier function. Overexpression of JAM-A is also closely associated with invasion and metastasis of cancers such as breast cancer, lung cancer and pancreatic cancer. However, little is known about the mechanism in overexpression of JAM-A in head and neck squamous cell carcinoma (HNSCC). In the present study, we found high expression of JAM-A at the protein and mRNA levels in HNSCC tissues, including those of the oropharynx, larynx, and hypopharynx, together with high protein expression of β-catenin, p63, ΔNp63 and GATA-3...
June 7, 2016: Oncotarget
https://www.readbyqxmd.com/read/26920888/functional-genomics-uncover-the-biology-behind-the-responsiveness-of-head-and-neck-squamous-cell-cancer-patients-to-cetuximab
#12
Paolo Bossi, Cristiana Bergamini, Marco Siano, Maria Cossu Rocca, Andrea P Sponghini, Federica Favales, Marco Giannoccaro, Edoardo Marchesi, Barbara Cortelazzi, Federica Perrone, Silvana Pilotti, Laura D Locati, Lisa Licitra, Silvana Canevari, Loris De Cecco
PURPOSE: To identify the tumor portrait of the minority of head and neck squamous cell carcinoma (HNSCC) patients with recurrent-metastatic (RM) disease who upon treatment with platinum-based chemotherapy plus cetuximab present a long-lasting response. EXPERIMENTAL DESIGN: The gene expression of pretreatment samples from 40 HNSCC-RM patients, divided in two groups [14 long-progression-free survival (PFS) and 26 short-PFS (median = 19 and 3 months, respectively)], was associated with PFS and was challenged against a dataset from metastatic colon cancer patients treated with cetuximab...
August 1, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/26872381/hypoxia-induces-tfe3-expression-in-head-and-neck-squamous-cell-carcinoma
#13
Zhi-Jun Sun, Guang-Tao Yu, Cong-Fa Huang, Lin-Lin Bu, Jian-Feng Liu, Si-Rui Ma, Wen-Feng Zhang, Bing Liu, Lu Zhang
To assess the role of transcription factor μE3 (TFE3) in the tumorigenesis of head and neck squamous cell carcinoma (HNSCC), human HNSCC tissue arrays were investigated for TFE3 expression. Human HNSCC tissues with neoadjuvant inductive chemotherapey (docetaxel, cisplatin and fluorouracil, TPF) and mice HNSCC tissues from transgenic mice model were evaluated for TFE3 expression and the hypoxia pathway. The roles of EGF/EGFR mediated hypoxia in TFE3 nuclear expression were analyzed in vitro and in vivo. TFE3 expression was higher in human HNSCC tissues compared with that in normal oral mucosa...
March 8, 2016: Oncotarget
https://www.readbyqxmd.com/read/26711490/comparative-analysis-of-transcriptomics-based-hypoxia-signatures-in-head-and-neck-squamous-cell-carcinoma
#14
COMPARATIVE STUDY
Bouchra Tawk, Christian Schwager, Oliver Deffaa, Gerhard Dyckhoff, Rolf Warta, Annett Linge, Mechthild Krause, Wilko Weichert, Michael Baumann, Christel Herold-Mende, Jürgen Debus, Amir Abdollahi
BACKGROUND AND PURPOSE: Hypoxia renders tumors resistant to radiotherapy. However, the paucity of sensitive and reliable methods for detection of tumor hypoxia limits the translation of novel therapy strategies targeting this well-known resistance factor. We sought to investigate the ability of three previously discovered transcriptomics based hypoxia signatures to identify hypoxic tumors and consequently discriminate between patients with poor- vs. good prognosis. MATERIAL AND METHODS: Three different hypoxia gene signatures developed by Toustrup et al...
February 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/26599270/impact-of-p16-alterations-and-pretreatment-anemia-on-toxicity-in-head-and-neck-cancer-patients-undergoing-definitive-radiochemotherapy
#15
Martina Becker-Schiebe, Matthias Sperling, Uwe Pinkert, Wolfgang Hoffmann
BACKGROUND: Human papilloma virus (HPV) infection, p16 expression and hypoxia may play important roles in the carcinogenesis, treatment response and toxicities of head and neck squamous cell carcinoma (HNSCC). The aim of this analysis was to assess whether there is any correlation between pre-radiotherapy (RT) anemia, p16 expression and toxicities and local control for patients undergoing definitive therapy. METHODS: 79 HNSCC patients who had undergone radiochemotherapy (RCT) or RT-antibody therapy were retrospectively analyzed...
2015: Oncology Research and Treatment
https://www.readbyqxmd.com/read/26481464/robustness-of-quantitative-hypoxia-pet-image-analysis-for-predicting-local-tumor-control
#16
David Mönnich, Stefan Welz, Daniela Thorwarth, Christina Pfannenberg, Gerald Reischl, Paul-Stefan Mauz, Konstantin Nikolaou, Christian la Fougère, Daniel Zips
BACKGROUND: Previous studies suggested the maximum tumor to background ratio (TBRmax) in FMISO PET images as a potentially predictive parameter for local control after radio-chemotherapy (CRT) in head and neck squamous cell carcinomas (HNSCC). However, different TBRmax thresholds for stratification were reported, implying that a common threshold cannot readily be used among different institutions without the risk of reducing prediction accuracy. Therefore, this study investigated the robustness of using a common pre-defined TBRmax, simulating a multicenter clinical trial...
2015: Acta Oncologica
https://www.readbyqxmd.com/read/26423449/the-effects-of-anesthesia-on-the-morphoproteomic-expression-of-head-and-neck-squamous-cell-carcinoma-a-pilot-study
#17
Jay K Ferrell, Davide Cattano, Robert E Brown, Chirag B Patel, Ron J Karni
The prognosis and disease-free survival rates for head and neck squamous cell carcinoma (HNSCC) have remained relatively stagnant for the last several decades. Moreover, as is the case with other malignancies, locoregional recurrence and distant metastasis are all too common even after seemingly successful oncologic surgery and adjuvant therapy. Recently, increased focus has been placed on understanding the influence of perioperative factors on tumor cell behavior and surgical outcomes. More specifically, emerging research suggests that anesthetic agents may play a role in cancer recurrence by interacting with prosurvival protein signaling pathways which harden tumor cells against oncologic treatments...
December 2015: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/26376962/acute-tumor-lactate-perturbations-as-a-biomarker-of-genotoxic-stress-development-of-a-biochemical-model
#18
Vlad C Sandulache, Yunyun Chen, Heath D Skinner, Tongtong Lu, Lei Feng, Laurence E Court, Jeffrey N Myers, Raymond E Meyn, Clifton D Fuller, James A Bankson, Stephen Y Lai
Ionizing radiation is the primary nonsurgical treatment modality for solid tumors. Its effectiveness is impacted by temporal constraints such as fractionation, hypoxia, and development of radioresistant clones. Biomarkers of acute radiation response are essential to developing more effective clinical algorithms. We hypothesized that acute perturbations in tumor lactate levels act as a surrogate marker of radiation response. In vitro experiments were carried out using validated human-derived cell lines from three histologies: anaplastic thyroid carcinoma (ATC), head and neck squamous cell carcinoma (HNSCC), and papillary thyroid carcinoma (PTC)...
December 2015: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/26351347/human-papillomavirus-negative-pharyngeal-cancer
#19
REVIEW
Magnus T Dillon, Kevin J Harrington
Human papillomavirus-negative head and neck squamous cell carcinoma (HNSCC) carries a poor prognosis, and despite optimal treatment with chemoradiotherapy to the limit of tolerance, many patients will relapse. A number of methods for intensifying treatment of HNSCC have been investigated, leading to the current standards of care. Novel agents targeting tumor cell and stromal signaling, DNA damage response, and immune system are now reaching clinical trials in combination with chemoradiotherapy. In this review, we discuss the evidence for the current treatment of locally advanced human papillomavirus-negative HNSCC, as well as investigational therapies, such as hypoxia modification, molecular targeting of epidermal growth factor receptor family, vascular endothelial growth factor receptor or DNA damage response proteins in combination with radiation therapy...
October 10, 2015: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/26266202/pre-radiotherapy-haemoglobin-level-is-a-prognosticator-in-locally-advanced-head-and-neck-cancers-treated-with-concurrent-chemoradiation
#20
Rajesh Kar Narayanaswamy, Mahadev Potharaju, A N Vaidhyswaran, Karthikeyan Perumal
INTRODUCTION: Radiation plays a major role in treatment of locoregional control of Head and Neck Squamous cell carcinoma (HNSCC). Anaemia is considered a contributor to intra-tumour hypoxia and tumour resistance to ionizing radiation and most evidences are from developed world, we prospectively investigated the exact role of anaemia in treatment outcome of Stage III/IVA HNSCC in our patient population. AIM OF THE STUDY: Primary end point: To analyse the Pre-Radiotherapy haemoglobin level and early response of treatment in stage III/IVA HNSCC and to determine the relationship of Pre-Radiotherapy haemoglobin level with other prognostic factors...
June 2015: Journal of Clinical and Diagnostic Research: JCDR
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