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vaginal intraepithelial neoplasia

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https://www.readbyqxmd.com/read/28716490/-self-evaluation-of-conization-indications-since-the-introduction-of-the-french-colposcopy-and-cervico-vaginal-pathology-quality-charter-in-2%C3%A2-colposcopy-centers
#1
M Lallemant, C Baeza, C Monnin, M Malincenco, C Gay
OBJECTIVES: Analyze the efficiency of the implementation of the colposcopy and cervico-vaginal pathology quality charter. The question was to determine whether the criteria of more than 70% of excisional conizations containing CIN2+ lesions (cervical intraepithelial neoplasia 2 or 3 or carcinoma in situ) had been reached and demonstrate a reduction of the conization rate is possible. METHODS: An epidemiological descriptive, retrospective and multicenter study was performed in "Nord Franche-Comté Hospitals" (Belfort and Montbéliard, France) during the period from November 2013 to January 2015...
July 14, 2017: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/28682436/colposcopic-patterns-of-vaginal-intraepithelial-neoplasia-a-focus-on-low-grade-lesions
#2
F Sopracordevole, N Clemente, M Barbero, A Agarossi, P Cattani, P Garutti, M G Fallani, A Pieralli, F Boselli, A Frega, G De Piero, A Del Fabro, M Buttignol, A Ciavattini
OBJECTIVE: The aim of this study was to evaluate the colposcopic patterns observed in women with a histopathological diagnosis of vaginal intraepithelial neoplasia, with a particular interest in analyzing the colposcopic characteristics of low-grade squamous intraepithelial lesions (LSIL). PATIENTS AND METHODS: Medical charts and colposcopy records of women diagnosed with vaginal intraepithelial neoplasia from January 1995 to December 2015, were analyzed in a multicenter retrospective case series...
June 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28667573/urologic-dermatology-a-review
#3
REVIEW
Andrew W Stamm, Kathleen C Kobashi, Ksenija B Stefanovic
PURPOSE OF REVIEW: Genital dermatology represents a challenge to many providers. Though dermatologic lesions involving the genitalia may present to any of a number of practices, ranging from primary care to urology, gynecology, and dermatology, few training programs provide significant training regarding the diagnosis and management of genital dermatologic lesions. The purpose of this review is to provide urologists with an overview of common genital dermatological lesions that may be encountered in a clinic...
August 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28644191/yield-of-cytology-surveillance-after-high-grade-vulvar-intraepithelial-neoplasia-or-cancer
#4
Lindsay M Kuroki, Antonina I Frolova, Ningying Wu, Jingxia Liu, Matthew Powell, Premal H Thaker, L Stewart Massad
OBJECTIVES: The aim of the study was to estimate the risk of high-grade cervical and vaginal intraepithelial neoplasia (CIN/VAIN 2+) and cancer among women treated surgically for high-grade vulvar intraepithelial neoplasia (HGVIN) and vulvar cancer. MATERIALS AND METHODS: We performed a retrospective cohort study of women who underwent surgery for HGVIN/vulvar cancer between 2006 and 2010. Univariate and multivariate analyses using stepwise selection were used to identify correlates of abnormal cytology after treatment for VIN and vulvar cancer...
July 2017: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/28637906/anogenital-warts-and-other-hpv-associated-anogenital-lesions-in-the-hiv-positive-patient-a-systematic-review-and-meta-analysis-of-the-efficacy-and-safety-of-interventions-assessed-in-controlled-clinical-trials
#5
Ricardo Niklas Werner, Lukas Westfechtel, Corinna Dressler, Alexander Nast
OBJECTIVES: Anogenital warts (AGW, condylomata acuminata) and intraepithelial neoplasia (IEN) do not only impact health and social well-being, they are also associated with considerable costs for the healthcare systems. Immunocompromised and HIV-positive patients carry the highest epidemiological burden of human papillomavirus (HPV) infection and comprise a population specifically susceptible to treatment failures and recurrences. This systematic review aimed at identifying and appraising the available evidence from controlled studies of interventions for the treatment of AGW and IEN in immunocompromised patients...
June 21, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28610416/bacterial-vaginosis-and-cervical-intraepithelial-neoplasia-is-there-an-association-or-is-co-existence-incidental
#6
Pushpa Sodhani, Sanjay Gupta, Ruchika Gupta, Ravi Mehrotra
Objectives: To determine associations, if any, of bacterial vaginosis with cervical pre-neoplastic lesions and evaluate any effects of sub-categorization of smears with bacterial vaginosis. Methods: All cervico-vaginal smears reported as positive for bacterial vaginosis over a five-year period were reviewed and sub-categorized into ‘type I (dysbacteriosis)’ and ‘type II (pure Gardenerella infection)’ smears by two cytopathologists (PS, SG). The proportion of smears with healthy flora and pre-neoplastic lesions was compared with those having bacterial vaginosis in conjunction with such changes...
May 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28564641/the-role-of-self-collection-by-vaginal-lavage-for-the-detection-of-hpv-and-high-grade-intraepithelial-neoplasia
#7
Larissa de Melo Kuil, Adriana Tarla Lorenzi, Maíra Degiovani Stein, Júlio César Possati Resende, Márcio Antoniazzi, Adhemar Longatto-Filho, Christóvam Scapulatempo-Neto, José Humberto Tavares Guerreiro Fregnani
OBJECTIVE: To compare the results of cervical cytology and high-risk HPV tests using samples obtained using two different collection modalities in a population of Brazilian women: self-collection (vaginal lavage) and cervical Pap testing. METHODS: We enrolled 204 women who were aged 18-64 years and had previously obtained abnormal cervical cytology test results; 83.8% of them agreed to participate. The sample was divided into two aliquots: one for the cytological study and one for the molecular analysis of high-risk HPV...
June 1, 2017: Acta Cytologica
https://www.readbyqxmd.com/read/28541790/long-lasting-increased-risk-of-human-papillomavirus-related-carcinomas-and-premalignancies-after-cervical-intraepithelial-neoplasia-grade-3-a-population-based-cohort-study
#8
Renée M F Ebisch, Dominiek W E Rutten, Joanna IntHout, Willem J G Melchers, Leon F A G Massuger, Johan Bulten, Ruud L M Bekkers, Albert G Siebers
Purpose The aim of this study was to determine the risk of human papillomavirus (HPV)-related carcinomas and premalignancies in women diagnosed with cervical intraepithelial neoplasia grade 3 (CIN3). Knowledge of this risk is important to preventing the development and progression of other HPV-related premalignancies and carcinomas, by considering prophylactic HPV vaccination and/or by paying increased attention to other HPV-related carcinomas and premalignancies when CIN3 is identified. Methods Women diagnosed with a CIN3 between 1990 and 2010 were identified from the Dutch nationwide registry of histopathology and cytopathology (PALGA) and matched with a control group of women without CIN3...
May 25, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28541626/risk-factors-for-unrecognized-invasive-carcinoma-in-patients-with-vulvar-high-grade-squamous-intraepithelial-lesion-at-vulvoscopy-directed-biopsy
#9
Mario Preti, Lauro Bucchi, Bruno Ghiringhello, Silvana Privitera, Valentina Frau, Elisabetta Corvetto, Chiara Benedetto, Leonardo Micheletti
OBJECTIVE: To evaluate the prevalence and risk factors for unrecognized invasive carcinoma in a series of patients undergoing surgical excision after an office biopsy of vulvar high-grade squamous intraepithelial lesion (VHSIL). METHODS: Two hundred and sixteen consecutive patients treated in a tertiary-level referral center for vulvar disease in north-western Italy were recruited. Patients' records were reviewed by trained personnel. Factors showing a statistically significant (p<0...
July 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/28529603/risk-factors-for-cervical-intraepithelial-neoplasia-and-cervical-cancer-in-chinese-women-large-study-in-jiexiu-shanxi-province-china
#10
Zhilian Wang, Jintao Wang, Jinrong Fan, Weihong Zhao, Xin Yang, Lingmei Wu, Dongyan Li, Ling Ding, Wei Wang, Junjie Xu, Michelle Stram, Chengquan Zhao, Min Hao
We aimed to investigate the risk factors for cervical intraepithelial neoplasia (CIN) in Jiexiu, Shanxi Province, China. Twenty thousand eligible married women (age: 18-65 years) were administered with a questionnaire on potential risk factors for CIN and underwent liquid based Pap test. All women with abnormal cytological results underwent colposcopy with biopsy. Based on the biopsy pathology results, women were then assigned to either study group (with CIN) or control group (negative for histological results and volunteered to participate in the follow up study)...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28445274/clinical-analysis-of-cervical-intraepithelial-neoplasia-with-vaginal-intraepithelial-neoplasia
#11
COMPARATIVE STUDY
Yue He, Qun Zhao, Yu-Ning Geng, Shu-Li Yang, Cheng-Hong Yin, Yu-Mei Wu
The purpose of this prospective cohort study is to evaluate the importance of screening and its diagnostic accuracy compared with the pathological diagnosis of cervical intraepithelial neoplasia (CIN) with vaginal intraepithelial neoplasia (VAIN).The prospective study enrolled 419 patients (pts) and was conducted between February 1, 2015 and January 31, 2016 at Beijing Obstetrics and Gynecology Hospital, Capital Medical University.All enrolled pts underwent multipoint biopsy of cervix and vaginal wall directed by colposcopy...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28441839/-detection-trend-of-vaginal-intraepithelial-neoplasia-diagnosed-by-colposcopy-guided-biopsy-from-2013-to-2015
#12
Q Cong, Q Wang, S J Gao, H W Zhang, M Du, F Xie, J Dong, H Feng, R L Zheng, M Chen, C Y Zhu, W J Diao, Y Song, Q S Guo, Y Y Li, L M Chen, Y K Cao, L Sui
Objective: To explore the detection trend of vaginal intraepithelial neoplasia (VaIN) of lower genital tract from 2013 to 2015. Methods: A retrospective analysis was undertaken of colposcopy-directed biopsy of cervical, vaginal and vulvar intraepithelial neoplasia lesions include cervical intraepithelial neoplasia (CIN), VaIN and vulvar intraepithelial neoplasia (VIN) in Obstetrics and Gynecology Hospital of Fudan University from January 2013 to December 2015. Results: (1) Overall data of CIN, VaIN and VIN: a total of 16 732 cases were diagnosed of lower genital intraepithelial neoplasia in 3 years, accounting for 23...
April 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/28436097/the-vaginal-microbiome-and-gynaecological-cancer-exercise-caution-when-considering-causation
#13
N C Ramchander, E J Crosbie
No abstract text is available yet for this article.
April 24, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28418208/accuracy-of-self-collected-human-papillomavirus-samples-from-japanese-women-with-abnormal-cervical-cytology
#14
Kawano-Yashiro Aiko, Motoki Yoko, Oba Mari Saito, Asano Ryoko, Maruyama Yasuyo, Asai-Sato Mikiko, Yamanaka Takeharu, Hirahara Fumiki, Miyagi Etsuko
AIM: The aim of this study was to assess the accuracy of self-collected vaginal samples compared with physician-collected cervical samples for high-risk human papillomavirus (HPV) testing in Japanese women with abnormal cervical cytology. We also assessed the acceptability of self-collected HPV (sHPV) testing using a questionnaire. METHODS: Women aged 20-69 years (n = 136) attending Yokohama City University Hospital because of abnormal cervical cytology between April 2014 and January 2015 were enrolled in this study...
April 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28380476/vaginal-neoplasia-induced-by-an-unusual-papillomavirus-subtype-in-a-woman-with-inherited-chromosomally-integrated-human-herpesvirus-type-6a
#15
Maxime Pichon, Alexandre Gaymard, Karine Lebail-Carval, Emilie Frobert, Etienne Beaufils, Gautier Chene, Massimo Tommasino, Bruno Lina, Pascal Gaucherand, Agnès Gautheret-Dejean, Pascale Bonnafous, Tarik Gheit, Annie Buenerd, Gery Lamblin, Yahia Mekki
We describe here a case of high-grade vaginal squamous lesion in a 54-year-old woman with a papillomaviruses (HPV) genital infection that developed from a cervical low-grade squamous intraepithelial lesion (SIL) to a high-grade SIL (H-SIL) on cytological examination. A colposcopy exam led to the detection of suspect vaginal lesions with granulomatous infiltrations, which were classified as a Vaginal Intra-Epithelial Neoplasia grade 2 after pathologists' analyses. After a laser vaginal surgery and a loop excision of the transformation zone, the analyses of the anatomical pieces using a near-complete HPV screening panel revealed an HPV-4 infection that was not detected before in cervical smears...
2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28357043/recent-advances-in-understanding-and-preventing-human-papillomavirus-related-disease
#16
REVIEW
Karin Hellner, Lucy Dorrell
High-risk human papillomaviruses (hrHPV) are responsible for anogenital and oropharyngeal cancers, which together account for at least 5% of cancers worldwide. Industrialised nations have benefitted from highly effective screening for the prevention of cervical cancer in recent decades, yet this vital intervention remains inaccessible to millions of women in low- and middle-income countries (LMICs), who bear the greatest burden of HPV disease. While there is an urgent need to increase investment in basic health infrastructure and rollout of prophylactic vaccination, there are now unprecedented opportunities to exploit recent scientific and technological advances in screening and treatment of pre-invasive hrHPV lesions and to adapt them for delivery at scale in resource-limited settings...
2017: F1000Research
https://www.readbyqxmd.com/read/28178576/the-association-of-pre-treatment-hpv-subtypes-with-recurrence-of-vin
#17
Giorgio Bogani, Fabio Martinelli, Antonino Ditto, Mauro Signorelli, Francesca Taverna, Claudia Lombardo, Valentina Chiappa, Umberto Leone Roberti Maggiore, Dario Recalcati, Cono Scaffa, Stefania Perotto, Ilaria Sabatucci, Alice Indini, Domenica Lorusso, Francesco Raspagliesi
OBJECTIVE: To assess whether pre-treatment HPV types are associated with recurrence of high-grade vulvar intraepithelial neoplasia (VIN2+). STUDY DESIGN: Data of consecutive patients with pretreatment HPV DNA test undergoing treatment for VIN2+ were retrospectively collected. Risk factors promoting the risk of VIN2+ persistence and recurrence were analyzed using Kaplan-Meier and Cox hazard proportional models. RESULTS: 64 patients had pretreatment vulvar-vaginal HPV DNA test...
February 1, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28109322/adar1-overexpression-is-associated-with-cervical-cancer-progression-and-angiogenesis
#18
Ying Chen, He Wang, Wenyi Lin, Ping Shuai
BACKGROUND: This study aimed to assess the role of RNA-dependent adenosine deaminase (ADAR1) in cervical squamous cell carcinoma occurrence and progression. METHODS: ADAR1 expression levels in stage IA and stage IIA cervical squamous cell carcinoma (group A), cervical intraepithelial neoplasia (CIN) specimens (group B), as well as normal and inflamed cervical tissue samples (group C) were assessed by immunohistochemistry. Clinical and pathological data of cervical squamous cell carcinoma patients undergoing surgery were retrospectively evaluated...
January 21, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/28109160/antibiotics-for-infection-prevention-after-excision-of-the-cervical-transformation-zone
#19
REVIEW
Chumnan Kietpeerakool, Bandit Chumworathayi, Jadsada Thinkhamrop, Butsakorn Ussahgij, Pisake Lumbiganon
BACKGROUND: Excision of the transformation zone of the cervix is the most commonly used approach to treat cervical precancerous lesions (cervical intraepithelial neoplasia (CIN)) to reduce the risk of developing cervical cancer. As the excision of the transformation zone leaves a raw area on the cervix, there is a risk of infection following the procedure. The incidence of infection after cold knife conization (CKC) is 36%, whereas the incidence for large loop excision of the transformation zone (LLETZ, also known as loop electrical excision procedure (LEEP)) is much lower (0...
January 21, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28052370/acantholytic-dermatosis-of-the-vagina-the-diagnostic-challenge-of-acantholytic-disease-in-the-genital-region
#20
J Kentley, R Cerio, M Khorshid, K Gibbon
We report the case of a 24-year-old woman with an 8-month history of deep pelvic pain and postcoital bleeding. Examination revealed desquamation of the vaginal epithelium with tender fissured plaques in the vagina, initially thought to be vaginal intraepithelial neoplasia. Histology showed squamous mucosa with suprabasal acantholysis and hyperkeratosis, and no evidence of viral infection, dysplasia or malignancy. These findings were consistent with acantholytic dermatosis (AD), a rare lesion that resembles Hailey-Hailey and Darier disease histopathologically, but can be distinguished on a clinical basis...
January 4, 2017: Clinical and Experimental Dermatology
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