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vaginal intraepithelial neoplasia

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https://www.readbyqxmd.com/read/29756652/laser-treatment-for-women-with-high-grade-vaginal-intraepithelial-neoplasia-a-propensity-matched-analysis-on-the-efficacy-of-ablative-versus-excisional-procedures
#1
Giorgio Bogani, Antonino Ditto, Fabio Martinelli, Lavinia Mosca, Valentina Chiappa, Diego Rossetti, Umberto Leone Roberti Maggiore, Ilaria Sabatrucci, Domenica Lorusso, Francesco Raspagliesi
OBJECTIVE: To investigate the long-term effectiveness of LASER treatment in women affected by high-grade vaginal intra-epithelial neoplasia. METHODS: Data of consecutive women treated for high-grade vaginal intra-epithelial neoplasia were retrieved. Efficacy and long-term effectiveness of ablative and excisional procedures were tested using a propensity-matched algorithm. Risk of recurrence over the time was assessed using Kaplan-Meier and Cox models. RESULTS: Overall, 204 patients met the inclusion criteria...
May 14, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29683909/acog-committee-opinion-no-734-the-role-of-transvaginal-ultrasonography-in-evaluating-the-endometrium-of-women-with-postmenopausal-bleeding
#2
(no author information available yet)
Cancer of the endometrium is the most common type of gynecologic cancer in the United States. Vaginal bleeding is the presenting sign in more than 90% of postmenopausal women with endometrial carcinoma. Clinical risk factors for endometrial cancer, including but not limited to age, obesity, use of unopposed estrogen, specific medical comorbidities (eg, polycystic ovary syndrome, type 2 diabetes mellitus, atypical glandular cells on screening cervical cytology), and family history of gynecologic malignancy also should be considered when evaluating postmenopausal bleeding...
May 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29683904/acog-committee-opinion-no-734-summary-the-role-of-transvaginal-ultrasonography-in-evaluating-the-endometrium-of-women-with-postmenopausal-bleeding
#3
(no author information available yet)
Cancer of the endometrium is the most common type of gynecologic cancer in the United States. Vaginal bleeding is the presenting sign in more than 90% of postmenopausal women with endometrial carcinoma. Clinical risk factors for endometrial cancer, including but not limited to age, obesity, use of unopposed estrogen, specific medical comorbidities (eg, polycystic ovary syndrome, type 2 diabetes mellitus, atypical glandular cells on screening cervical cytology), and family history of gynecologic malignancy also should be considered when evaluating postmenopausal bleeding...
May 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29575422/differentiated-cervical-intraepithelial-neoplasia-associated-invasive-cervical-squamous-cell-carcinoma-as-a-source-of-major-cytopathological-and-surgical-pathological-discrepancy-in-papanicolaou-smear-screening-tests
#4
K T Mai
INTRODUCTION: Differentiated cervical intraepithelial neoplasia (dCIN) analogous to differentiated squamous intraepithelial neoplasia of the vulva is characterised by the proliferation of atypical cells limited to the basal/parabasal layers. Exfoliative cytology of dCIN has not been investigated. METHODS AND RESULTS: A 46-year-old woman, with a history of normal Papanicolaou (Pap) smear up to 2 years prior to the occurrence of postcoital vaginal bleeding had two consecutive Pap smears, which only revealed atypical squamous cells of unknown significance (ASCUS)...
April 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29570565/p16-immunohistochemistry-is-not-always-required-for-accurate-diagnosis-of-grade-2-squamous-intraepithelial-lesions
#5
Lulu Sun, Lingxin Zhang, Hannah R Krigman, Ian S Hagemann
OBJECTIVES: Preinvasive squamous neoplasms of the lower genital tract are currently classified using a two-tier system (high- or low-grade squamous intraepithelial lesion) as directed by the Lower Anogenital Squamous Terminology (LAST) guidelines but may also be subclassified as intraepithelial neoplasia grade 1 (-IN1), -IN2, or -IN3. The LAST recommended that all diagnoses of -IN2 be supported by immunohistochemistry (IHC) for p16. We examined whether p16 and Ki-67 IHC are necessary to diagnose -IN2 when the lesion has obvious high-grade histology...
April 2018: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/29512809/the-prevelance-of-human-papillomavirus-hpv-genotypes-detected-by-pcr-in-women-with-normal-and-abnormal-cervico-vaginal-cytology
#6
Fatma Beyazit, Fatma Sılan, Meryem Gencer, Buket Aydin, Barış Paksoy, Mesut A Unsal, Ozturk Ozdemir
OBJECTIVES: Cervical cancer is the second most common type of cancer for women worldwide with a great proportion proved to be related to human papillomavirus (HPV) infection. As infection with HPV is the strongest risk factor for cervical neoplasia, detection of HPV genotypes in cervical and vaginal specimens of women with normal and abnormal cytology seems to be of paramount importance in cervical cancer screening. The objective of the study is to evaluate the prevalence and HPV genotypes among women with normal or abnormal Pap smear tests...
2018: Ginekologia Polska
https://www.readbyqxmd.com/read/29470358/is-vulvovaginal-lichen-planus-associated-with-squamous-cell-carcinoma
#7
Tania Day, Geoff Otton, Ken Jaaback, Julie Weigner, James Scurry
OBJECTIVE: The aim of the study was to assess for the presence of vulvar lichen planus (LP) in association with human papillomavirus (HPV)-independent squamous cell carcinoma (SCC). MATERIALS AND METHODS: We performed a clinicohistopathologic review of consecutive vulvectomies and wide local excisions for HPV-independent vulvar or vaginal SCC from 2007 to 2017. Data collected included site of SCC, adjacent precursor lesions and dermatoses, dermatologic treatment, and outcome...
April 2018: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/29438367/randomised-study-shows-that-repeated-self-sampling-and-hpv-test-has-more-than-two-fold-higher-detection-rate-of-women-with-cin2-histology-than-pap-smear-cytology
#8
Inger Gustavsson, Riina Aarnio, Malin Berggrund, Julia Hedlund-Lindberg, Ann-Sofi Strand, Karin Sanner, Ingrid Wikström, Stefan Enroth, Matts Olovsson, Ulf Gyllensten
This corrects the article DOI: 10.1038/bjc.2017.85.
March 20, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29405269/outcomes-for-women-without-conventional-treatment-for-stage-1a-microinvasive-carcinoma-of-the-cervix
#9
Charlotte Paul, Katrina J Sharples, Judith Baranyai, Ronald W Jones, David Cg Skegg
BACKGROUND: An unethical clinical study that entailed withholding treatment from women diagnosed with cervical intraepithelial neoplasia 3 (CIN3) was conducted at National Women's Hospital, Auckland, New Zealand. Women with microinvasive carcinoma of the cervix also had treatment withheld. AIMS: To describe the management and outcomes for women with microinvasive carcinoma for many of whom conventional treatment was withheld. MATERIALS AND METHODS: Retrospective cohort study of women with a diagnosis of stage 1A cervical carcinoma at National Women's Hospital...
February 6, 2018: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29396352/risk-of-high-risk-human-papillomavirus-infection-and-cervical-precancerous-lesions-with-past-or-current-trichomonas-infection-a-pooled-analysis-of-25-054-women-in-rural-china
#10
Rui-Mei Feng, Margaret Z Wang, Jennifer S Smith, Li Dong, Feng Chen, Qin-Jing Pan, Xun Zhang, You-Lin Qiao, Fang-Hui Zhao
BACKGROUND: Trichomonas vaginitis (TV) infection has obviously been implicated in gynecological morbidity but still unclear in cervical lesions. OBJECTIVE: To evaluate the risk of hr-HPV infection and cervical intraepithelial neoplasia grade 2 or worse (CIN2 + ) by TV infection. STUDY DESIGN: The pooled study was conducted among 12 population-based, cervical cancer screening studies throughout China (N = 24,054). HPV was detected by Hybrid Capture® 2 (HC2) test...
February 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29297962/postmenopausal-labial-agglutination-mimics-urinary-incontinence-and-hidden-vaginal-lesion
#11
Buo-Jia Lu, Hung-Yen Chin, Chia-Ying Chu, Jimmy T J Wang
Labial agglutination has rarely been reported in postmenopausal women and its treatment has been based on experience with prepubertal girls. We describe an 83-year-old woman who presented with labial agglutination and severe urinary incontinence. She had been treated intermittently with a topical estrogen cream for 3 years, but her symptoms persisted. Surgery was performed and her urinary incontinence was instantly resolved. Incidental vaginal low-grade squamous intraepithelial neoplasia was noted. Later, the lesion progressed and was confirmed to be condyloma acuminata...
January 3, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29279588/comparison-of-the-sensitivity-and-specificity-of-p16-ki-67-dual-staining-and-hpv-dna-testing-of-abnormal-cervical-cytology-in-the-detection-of-histology-proven-cervical-intraepithelial-neoplasia-grade-2-and-above-cin-2
#12
T K Y Tay, K L Lim, M H Hilmy, A A Thike, S T Goh, L H Song, J S G Hwang, S Mantoo
INTRODUCTION: Human papillomavirus (HPV) testing is used as a means of triaging cervico-vaginal smears with low grade squamous abnormalities or as part of co-testing with cytology. While HPV testing has a high sensitivity, it has a low specificity in detecting cervical intraepithelial neoplasia grade 2 and above (CIN 2+) leading to unnecessary colposcopy referrals. We investigate the accuracy of the p16/Ki-67 dual immunocytochemical stain in determining the presence of CIN 2+ lesions on histology and its potential as a superior biomarker for triage...
December 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/29238232/efficacy-of-thermoablation-in-treating-cervical-precancerous-lesions-in-a-low-resource-setting
#13
Phuong Lien Tran, Bruno Kenfack, Eveline Tincho Foguem, Manuela Viviano, Liliane Temogne, Pierre-Marie Tebeu, Rosa Catarino, Anne-Caroline Benski, Pierre Vassilakos, Patrick Petignat
Introduction: Treating cervical intraepithelial neoplasia (CIN) grades 2 and 3 is the recommended strategy for preventing invasive carcinoma in low- and middle-income countries (LMICs). Our objective was to assess the efficacy of thermoablation in the treatment of CIN2 and CIN3 in a screen-and-treat approach. Methods: Women aged 30-49 years in Dschang, Cameroon, were invited to undergo vaginal sampling for human papillomavirus (HPV), samples being assessed by an Xpert HPV Assay...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/29223961/a-systematic-review-and-meta-analysis-of-studies-evaluating-the-performance-of-point-of-care-tests-for-human-papillomavirus-screening
#14
REVIEW
Helen Kelly, Philippe Mayaud, Michel Segondy, Nitika Pant Pai, Rosanna W Peeling
BACKGROUND: High-risk human papillomavirus (HPV) is a necessary cause of high-grade cervical intraepithelial neoplasia (grade 2 or higher, CIN2+). Simplified and rapid HPV DNA assays designed for use in resource-limited settings have recently become available. METHODS: We performed a systematic review and meta-analysis by searching Medline, Embase, Global Health and CINAHL databases for studies from 1 January 2004 to 25 February 2017 that reported the performance of care HPV or OncoE6 for the detection of histological CIN2+ in cervical cancer screening...
December 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29207889/primary-carcinosarcoma-of-the-vagina-associated-with-differentiated-squamous-intraepithelial-neoplasia-in-a-patient-with-complete-uterine-prolapse-case-report-and-review-of-the-literature
#15
Emina Babarović, Karla Sladoljev, Ena Perin, Marko Klarić, Ružica Karnjuš-Begonja, Tamara Sinožić, Morana Dinter, Lana Glavan Gačanin, Senija Eminović
Vaginal carcinosarcomas (VCSs) are rare and clinically aggressive neoplasms. Primary vaginal malignancies are among the rarest malignant tumors, so clear management guidelines and optimal therapy, especially in the presence of significant pelvic organ prolapse, has not been determined. Here, we present a case of primary VCS closely associated with differentiated squamous intraepithelial neoplasia (DSIN), from which it appeared to have arisen in a postmenopausal patient with complete uterine prolapse. The unusual presentation of our case with DSIN in the adjacent vaginal epithelium with possible diagnostic pitfalls emphasizes the need for systemic presentation of these cases to help pathologists and clinicians know that such lesions can initially present in a patient with complete uterine prolapse...
December 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29185264/clinical-outcomes-and-risk-of-recurrence-among-patients-with-vaginal-intraepithelial-neoplasia-a-comprehensive-analysis-of-576-cases
#16
Mi Kyung Kim, In Ho Lee, Ki Heon Lee
OBJECTIVE: To evaluate the clinical outcomes of vaginal intraepithelial neoplasia (VAIN) and to assess the risk of recurrence and progression to invasive vaginal carcinoma. METHODS: A retrospective review of the clinicopathologic data and clinical outcomes was performed on patients who were diagnosed with VAIN at a single center between January 2000 and July 2016. Demographics, treatments, and clinical outcomes were abstracted from medical records. RESULTS: A total of 576 patients with VAIN1-3 were included in the study analysis...
January 2018: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29157955/development-of-a-goat-model-for-evaluation-of-withaferin-a-cervical-implants-for-the-treatment-of-cervical-intraepithelial-neoplasia
#17
Leslie C Sherwood, Farrukh Aqil, Manicka V Vadhanam, Jeyaprakash Jeyabalan, Radha Munagala, David Hoetker, Sanjay Srivastava, Inder P Singh, Scott Cambron, Martin O'Toole, Wendy Spencer, Lynn P Parker, Ramesh C Gupta
Cervical cancer is caused by human papillomavirus (HPV). The disease develops over many years through a series of precancerous lesions. Cervical cancer can be prevented by HPV-vaccination, screening and treatment of precancer before development of cervical cancer. The treatment of high-grade cervical dysplasia (CIN2+ ) has traditionally been by cervical conization. Surgical procedures are associated with increased risk of undesirable side effects including bleeding, infection, scarring (stenosis), infertility and complications in later pregnancies...
December 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/29126556/vulvar-intraepithelial-neoplasia-risk-factors-for-recurrence
#18
W Satmary, C H Holschneider, L L Brunette, S Natarajan
OBJECTIVE: We studied a large population of women with high-grade vulvar intraepithelial neoplasia (VIN) in order to identify patient and treatment-related risk factors for recurrence and progression to cancer. METHODS: For this retrospective cohort study of women with a histologic diagnosis of VIN within Southern California Permanente Medical Group between 1995 and 2007 medical records were reviewed; clinical, demographic and pathologic data were collected. Statistical analyses included Chi-squared and Student's t-tests, univariate and multivariate logistic regression, and cumulative incidence analysis...
January 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29112645/topical-5-fluorouracil-for-women-with-high-grade-vaginal-intraepithelial-neoplasia
#19
Stephen Fiascone, Allison F Vitonis, Sarah Feldman
OBJECTIVE: To examine success rates of 5-fluorouracil, excision, and laser ablation as the initial and secondary management strategies for women with high-grade vaginal intraepithelial neoplasia. METHODS: We conducted a retrospective case series of women referred to a single center for management of biopsy-proven, high-grade vaginal intraepithelial neoplasia between April 1994 and May 2016. Data including demographic characteristics, human papillomavirus risk factors, antecedent Pap cytology, concurrent or prior cervical and vulvar dysplasia, and treatment outcome including follow-up Pap cytology were recorded...
December 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28985547/efficacy-of-5-imiquimod-for-the-treatment-of-vaginal-intraepithelial-neoplasia-a-systematic-review-of-the-literature-and-a-meta-analysis
#20
REVIEW
A Tranoulis, A Laios, V Mitsopoulos, K Lutchman-Singh, N Thomakos
Vaginal intraepithelial neoplasia (VaIN) is an uncommon disease associated with HPV and is considered to be a precursor of vaginal carcinoma. To date, treatment recommendations vary with no universally accepted standard of care as best treatment modality. Nevertheless, 5% imiquimod appears to be a promising, alternative, non-invasive treatment option. To ascertain the efficacy of 5% imiquimod for the treatment of this rare condition, we conducted a systematic review and meta-analysis of the proportion of women who received 5% imiquimod with their complete response, HPV clearance and recurrence rates...
November 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
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