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https://www.readbyqxmd.com/read/29339663/evaluation-of-magnetic-resonance-imaging-ultrasound-fusion-biopsy-in-patients-with-low-risk-prostate-cancer-under-active-surveillance-undergoing-surveillance-biopsy
#1
Angelika Borkowetz, Theresa Renner, Ivan Platzek, Marieta Toma, Roman Herout, Martin Baunacke, Christer Groeben, Johannes Huber, Michael Laniado, Gustavo B Baretton, Michael Froehner, Stefan Zastrow, Manfred P Wirth
INTRODUCTION: Targeted biopsy of tumour-suspicious lesions detected in multiparametric magnetic resonance imaging (mpMRI) plays an increasing role in the active surveillance (AS) of patients with low-risk prostate cancer (PCa). The aim of this study was to compare MRI/ultrasound-fusion biopsy (fusPbx) with systematic biopsy (sysPbx) in patients undergoing biopsy for AS. METHODS: Patients undergoing mpMRI and transperineal fusPbx combined with transrectal sysPbx (comPbx) as surveillance biopsy were investigated...
January 16, 2018: Urologia Internationalis
https://www.readbyqxmd.com/read/29336979/prostate-magnetic-resonance-imaging-the-truth-lies-in-the-eye-of-the-beholder
#2
Joseph C Riney, Nabeel E Sarwani, Shehzad Siddique, Jay D Raman
PURPOSE: To determine the diagnostic accuracy and interobserver variability of radiologic interpretation of magnetic resonance imaging (MRI) performed for surgical planning before prostatectomy. PATIENTS AND METHODS: The records of 233 men undergoing prostatectomy with presurgical multiparametric 3T surface body coil MRI were reviewed. All initial films were read by a fellowship-trained body radiologist provided with relevant clinical information. A senior radiologist then reread all pelvic MRIs blinded to the initial interpretation with findings from both readings compared to final pathology...
January 11, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29333958/focal-mri-guided-salvage-high-dose-rate-brachytherapy-in-patients-with-radiorecurrent-prostate-cancer
#3
Metha Maenhout, Max Peters, Marco van Vulpen, Marinus A Moerland, Richard P Meijer, Maurice A A J van den Bosch, Paul L Nguyen, Steven J Frank, Jochem R N van der Voort van Zyp
INTRODUCTION: Whole-gland salvage treatment of radiorecurrent prostate cancer has a high rate of severe toxicity. The standard of care in case of a biochemical recurrence is androgen deprivation treatment, which is associated with morbidity and negative effects on quality of life. A salvage treatment with acceptable toxicity might postpone the start of androgen deprivation treatment, might have a positive influence on the patients' quality of life, and might even be curative. Here, toxicity and biochemical outcome are described after magnetic resonance imaging-guided focal salvage high-dose-rate brachytherapy in patients with radiorecurrent prostate cancer...
December 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/29331622/value-of-serial-multiparametric-magnetic-resonance-imaging-and-magnetic-resonance-imaging-guided-biopsies-in-men-with-low-risk-prostate-cancer-on-active-surveillance-after-1-yr-follow-up
#4
Esther Hendrika Johanna Hamoen, Caroline M A Hoeks, Diederik M Somford, Inge M van Oort, Henk Vergunst, Jorg R Oddens, Geert A Smits, Leonard P Bokhorst, J Alfred Witjes, Maroeska M Rovers, Christina A Hulsbergen-van de Kaa, Jelle O Barentsz
BACKGROUND: Active surveillance (AS) aims to reduce overtreatment of low-risk prostate cancer (PC). Incorporating multiparametric magnetic resonance imaging (mp-MRI) and MR-guided biopsy (MRGB) in an AS protocol might contribute to more accurate identification of AS candidates. OBJECTIVE: To evaluate the value of 3T mp-MRI and MRGB in PC patients on AS at inclusion and after 12-mo follow-up. DESIGN, SETTING, AND PARTICIPANTS: Patients with cT1c-cT2 PC, prostate-specific antigen (PSA) ≤10ng/ml, PSA density <0...
January 10, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29317377/multiparametric-mri-for-the-detection-of-local-recurrence-of-prostate-cancer-in-the-setting-of-biochemical-recurrence-after-low-dose-rate-brachytherapy
#5
Luca F Valle, Matthew D Greer, Joanna H Shih, Tristan Barrett, Yan Mee Law, Andrew B Rosenkrantz, Haytham Shebel, Akhil Muthigi, Daniel Su, Maria J Merino, Bradford J Wood, Peter A Pinto, Andra V Krauze, Aradhana Kaushal, Peter L Choyke, Barış Türkbey, Deborah E Citrin
PURPOSE: Prostate multiparametric magnetic resonance imaging (mpMRI) has utility in detecting post-radiotherapy local recurrence. We conducted a multireader study to evaluate the diagnostic performance of mpMRI for local recurrence after low dose rate (LDR) brachytherapy. METHODS: A total of 19 patients with biochemical recurrence after LDR brachytherapy underwent 3T endorectal coil mpMRI with T2-weighted imaging, dynamic contrast-enhanced imaging (DCE) and diffusion-weighted imaging (DWI) with pathologic confirmation...
January 2018: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/29312542/the-management-of-active-surveillance-in-prostate-cancer-validation-of-the-canary-prostate-active-surveillance-study-risk-calculator-with-the-spanish-urological-association-registry
#6
Ángel Borque-Fernando, José Rubio-Briones, Luis Mariano Esteban, Argimiro Collado-Serra, Yoni Pallás-Costa, Pedro Ángel López-González, Jorge Huguet-Pérez, José Ignacio Sanz-Vélez, Jesús Manuel Gil-Fabra, Enrique Gómez-Gómez, Cristina Quicios-Dorado, Lluis Fumadó, Sara Martínez-Breijo, Juan Soto-Villalba
The follow up of patients on active surveillance requires to repeat prostate biopsies. Predictive models that identify patients at low risk of progression or reclassification are essential to reduce the number of unnecessary biopsies. The aim of this study is to validate the Prostate Active Surveillance Study risk calculator (PASS-RC) in the multicentric Spanish Urological Association Registry of patients on active surveillance (AS), from common clinical practice. Results: We find significant differences in age, PSA and clinical stage between our validation cohort and the PASS-RC generation cohort (p < ...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29306515/multiparametric-magnetic-resonance-imaging-for-prostate-specific-antigen-recurrence-after-radical-prostatectomy-are-we-leaving-the-one-treatment-fits-all-approach-and-moving-towards-personalized-imaging-guided-treatment
#7
EDITORIAL
https://www.readbyqxmd.com/read/29303080/latest-evidence-on-the-role-of-multiparametric-magnetic-resonance-imaging-in-active-surveillance-for-insignificant-prostate-cancer-a-systematic-review
#8
Francesco Cantiello, Stefano Manno, Antonio Cicione, Rocco Damiano
OBJECTIVE: Multiparametric Magnetic Resonance Imaging (mpMRI) has become a very useful tool in the management of low risk Prostate Cancer (PCa) patients eligible for Active Surveillance (AS). The aim of this systematic review was to critically review the latest literature concerning the role of mpMRI in this clinical setting, underlying current strengths and weakness. EVIDENCE ACQUISITION: A comprehensive literature research for English-language original and review articles was carried out using the National Center for Biotechnology Information PubMed database with the aim of identify studies on mpMRI for AS in low risk PCa patients...
January 4, 2018: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29279171/support-vector-machines-svm-classification-of-prostate-cancer-gleason-score-in-central-gland-using-multiparametric-magnetic-resonance-images-a-cross-validated-study
#9
Jiance Li, Zhiliang Weng, Huazhi Xu, Zhao Zhang, Haiwei Miao, Wei Chen, Zheng Liu, Xiaoqin Zhang, Meihao Wang, Xiao Xu, Qiong Ye
PURPOSE: To assess the performance of Support Vector Machines (SVM) classification to stratify the Gleason Score (GS) of prostate cancer (PCa) in the central gland (CG) based on image features across multiparametric magnetic resonance imaging (mpMRI). MATERIALS AND METHODS: This retrospective study was approved by the institutional review board, and informed consent was waived. One hundred fifty-two CG cancerous ROIs were identified through radiological-pathological correlation...
January 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29275309/detection-of-local-recurrence-with-3-tesla-mri-after-radical-prostatectomy-a-useful-method-for-radiation-treatment-planning
#10
Daniel Buergy, Metin Sertdemir, Anja Weidner, Mohamed Shelan, Frank Lohr, Frederik Wenz, Stefan O Schoenberg, Ulrike I Attenberger
BACKGROUND/AIM: Salvage radiotherapy improves biochemical control in patients with recurrence of prostate cancer after prostatectomy. Radiotherapy target volumes of the prostatic fossa are based on empirical data and differ between different guidelines. Localization of recurrence with multiparametric magnetic resonance imaging (MRI) might be a feasible approach to localize recurrent lesions. PATIENTS AND METHODS: Twenty-one patients with biochemical recurrence after radical prostatectomy were included (median prostate-specific antigen (PSA) =0...
January 2018: In Vivo
https://www.readbyqxmd.com/read/29233150/a-prospective-study-of-magnetic-resonance-imaging-and-ultrasonography-mri-us-fusion-targeted-biopsy-and-concurrent-systematic-transperineal-biopsy-with-the-average-of-18-cores-to-detect-clinically-significant-prostate-cancer
#11
Yuji Hakozaki, Hisashi Matsushima, Jimpei Kumagai, Taro Murata, Tomoko Masuda, Yoko Hirai, Mai Oda, Nobuo Kawauchi, Munehiro Yokoyama, Yukio Homma
BACKGROUND: This study compared the detection rates for clinically significant prostate cancer (CSPC) between magnetic resonance imaging and ultrasonography (MRI/US)-fusion-targeted biopsy (TB), systematic biopsy (SB) and combination of TB and SB. METHODS: This prospective study evaluated simultaneous TB and SB for consecutive patients with suspicious lesions that were detected using pre-biopsy multiparametric MRI. A commercially available real-time virtual sonography system was used to perform the MRI/US-fusion TB with the transperineal technique...
December 12, 2017: BMC Urology
https://www.readbyqxmd.com/read/29226826/prostate-magnetic-resonance-imaging-interpretation-varies-substantially-across-radiologists
#12
Geoffrey A Sonn, Richard E Fan, Pejman Ghanouni, Nancy N Wang, James D Brooks, Andreas M Loening, Bruce L Daniel, Katherine J To'o, Alan E Thong, John T Leppert
BACKGROUND: Multiparametric magnetic resonance imaging (mpMRI) interpreted by experts is a powerful tool for diagnosing prostate cancer. However, the generalizability of published results across radiologists of varying expertise has not been verified. OBJECTIVE: To assess variability in mpMRI reporting and diagnostic accuracy across radiologists of varying experience in routine clinical care. DESIGN, SETTING, AND PARTICIPANTS: Men who underwent mpMRI and MR-fusion biopsy between 2014-2016...
December 6, 2017: European Urology Focus
https://www.readbyqxmd.com/read/29211932/targeted-versus-systematic-robot-assisted-transperineal-mri-trus-fusion-prostate-biopsy
#13
J Mischinger, S Kaufmann, G I Russo, N Harland, S Rausch, B Amend, M Scharpf, L Loewe, T Todenhoefer, M Notohamiprodjo, K Nikolaou, A Stenzl, J Bedke, S Kruck
OBJECTIVES: To evaluate the performance of transperineal robot-assisted (RA) targeted (TB) and systematic (SB) prostate biopsy in the primary and repeat biopsy setting. PATIENTS AND METHODS: Patients were admitted to RA biopsy between 2014-2016. Prior to RA-TB, multiparametric (mp) Magnetic Resonance Imaging (MRI) was performed. Prostate lesions were scored (Prostate Imaging, Reporting and Data System Version 2) and used for RA-TB planning. In addition, RA-SB was performed...
December 6, 2017: BJU International
https://www.readbyqxmd.com/read/29205162/multiparametric-mri-guided-biopsy-in-the-era-of-precision-medicine
#14
Miguel A Bergero, Pablo F Martínez, Jan P Radtke, Boris A Hadaschik
OBJECTIVE: Technical improvements in prostate magnetic resonance imaging (MRI) have resulted in the use of MRI to target prostate biopsy. This allowed urologists to progress from blind biopsies to target biopsies with a better performance in prostate cancer (PC) diagnosis. We herein review the current status of Magnetic Resonance Imaging Guided Biopsy (MRGB) for the detection of PC. METHODS: A systematic review of the literature was conducted using PubMed, Embase and Cochrane using the search criteria: "PC and MRI/US fusion" or "PC and guided biopsy" or "PC and multiparametric MRI" or "PC and MRI guided prostate biopsy"...
December 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29201511/robot-assisted-radical-perineal-prostatectomy-first-experience-of-15-cases
#15
Volkan Tuğcu, Oktay Akça, Abdulmuttalip Şimşek, İsmail Yiğitbaşı, Selçuk Şahin, Ali İhsan Taşçı
Objective: Minimally invasive techniques are increasingly evolving and preferred to reduce surgical induced morbidity and mortality and minimize the challenges of surgical techniques. Especially radical perineal prostatectomy (RPP) includes some challenges like working in a deep and narrow space and challenging ergonomics for the surgeons. Because of these issues open RPP is still performed in experienced centers. In order to reduce these difficulties, robot- assisted radical perineal prostatectomy (r-RPP) is developed...
December 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/29201510/the-efficacy-and-utilisation-of-preoperative-multiparametric-magnetic-resonance-imaging-in-robot-assisted-radical-prostatectomy-does-it-change-the-surgical-dissection-plan
#16
Hasan Hüseyin Tavukçu, Ömer Aytaç, Numan Cem Balcı, Haluk Kulaksızoğlu, Fatih Atuğ
Objective: We investigated the effect of the use of multiparametric prostate magnetic resonance imaging (mp-MRI) on the dissection plan of the neurovascular bundle and the oncological results of our patients who underwent robot-assisted radical prostatectomy. Material and methods: We prospectively evaluated 60 consecutive patients, including 30 patients who had (Group 1), and 30 patients who had not (Group 2) mp-MRI before robot-assisted radical prostatectomy. Based on the findings of mp-MRI, the dissection plan was changed as intrafascial, interfascial, and extrafascial in the mp-MRI group...
December 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/29201499/biparametric-mri-of-the-prostate
#17
REVIEW
Michele Scialpi, Alfredo D'Andrea, Eugenio Martorana, Corrado Maria Malaspina, Maria Cristina Aisa, Maria Napoletano, Emanuele Orlandi, Valeria Rondoni, Pietro Scialpi, Diamante Pacchiarini, Diego Palladino, Michele Dragone, Giancarlo Di Renzo, Annalisa Simeone, Giampaolo Bianchi, Luca Brunese
Biparametric Magnetic Resonance Imaging (bpMRI) of the prostate combining both morphologic T2-weighted imaging (T2WI) and diffusion-weighted imaging (DWI) is emerging as an alternative to multiparametric MRI (mpMRI) to detect, to localize and to guide prostatic targeted biopsy in patients with suspicious prostate cancer (PCa). BpMRI overcomes some limitations of mpMRI such as the costs, the time required to perform the study, the use of gadolinium-based contrast agents and the lack of a guidance for management of score 3 lesions equivocal for significant PCa...
December 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/29198639/baseline-multiparametric-mri-for-selection-of-prostate-cancer-patients-suitable-for-active-surveillance-which-features-matter
#18
Francesco Sanguedolce, Giuseppe Petralia, Heminder Sokhi, Elena Tagliabue, Nicola Anyamene, Giles Hellawell, Anwar R Padhani
INTRODUCTION: Increasing evidence has supported the use of multiparametric magnetic resonance imaging (mpMRI) for the detection of prostate cancer. However, its role in selecting patients clinically suitable for active surveillance (AS) is still in development. We aimed to find relevant mpMRI features that might be helpful for refinement of the selection of low-risk prostate cancer patients for AS. We also evaluated the interobserver variability in reporting prostate mpMRI features. PATIENTS AND METHODS: From 2008 to 2012, 135 patients were selected for AS using Epstein criteria...
November 21, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29197919/prostate-ultrasound-back-in-business
#19
REVIEW
Nicolae Crisan, Iulia Andras, Corina Radu, David Andras, Radu-Tudor Coman, Paul Tucan, Doina Pisla, Dana Crisan, Ioan Coman
The use of grey scale prostate ultrasound decreased after the implementation of magnetic resonance imaging (MRI) for the diagnosis and evaluation of prostate cancer. The new developments, such as multiparametric ultrasound and MRI-ultrasound fusion technology, renewed the interest for this imaging method in the assessment of prostate cancer. The purpose of this paper was to review the current role of prostate ultrasound in the setting of these new applications. A thorough reevaluation of the selection criteria of the patients is required to assess which patients would benefit from multiparametric ultrasound, who wouldbenefit from multiparametric MRI or the combination of both to assist prostate biopsy in order to ensure the balance between overdiagnosis and underdiagnosis of prostate cancer...
November 29, 2017: Medical Ultrasonography
https://www.readbyqxmd.com/read/29195777/multiparametric-magnetic-resonance-imaging-is-an-independent-predictor-of-salvage-radiotherapy-outcomes-after-radical-prostatectomy
#20
REVIEW
Vidit Sharma, Avinash Nehra, Michele Colicchia, Mary E Westerman, Akira Kawashima, Adam T Froemming, Eugene D Kwon, Lance A Mynderse, R Jeffrey Karnes
BACKGROUND: The Stephenson nomogram is widely used to estimate the success of salvage radiotherapy (sXRT) for prostate cancer (PCa) recurrence after radical prostatectomy (RP). OBJECTIVE: To determine whether multiparametric pelvic magnetic resonance imaging (mpMRI) performed for biochemical recurrence after RP improves prognostication of sXRT relative to the Stephenson nomogram. DESIGN, SETTING, AND PARTICIPANTS: Men undergoing RP at our institution from 2003 to 2012 who had biochemical recurrence evaluated by mpMRI within 12 mo of sXRT were retrospectively reviewed...
November 28, 2017: European Urology
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