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https://www.readbyqxmd.com/read/29331875/the-association-between-vitamin-d-receptor-polymorphisms-and-multiple-sclerosis-in-a-turkish-population
#1
Ozden Kamisli, Ceren Acar, Mert Sozen, Mehmet Tecellioglu, Fatma Ebru Yücel, Dilara Vaizoglu, Cemal Özcan
BACKGROUND: Multiple sclerosis (MS) is a chronic, demyelinating disease of the central nervous system (CNS). Genetic and environmental factors are important in disease development. Many studies have investigated the relationship between MS and VDR polymorphisms. VDR gene polymorphism has not been previously studied in Turkish MS patients. We aimed to investigate the relationship between MS and VDR genotypes Taq I, Apa I and Fok I polymorphisms in a Turkish population. METHODS: 167 MS patients and 146 healthy control subjects were included in the present study...
January 9, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29328985/standing-on-a-sliding-board-affects-generation-of-anticipatory-and-compensatory-postural-adjustments
#2
Bing Chen, Yun-Ju Lee, Alexander S Aruin
Postural control is compromised in the presence of body instability. We studied anticipatory and compensatory postural adjustments people use to maintain balance while standing on an unstable surface and performing voluntary arm movements. Nine healthy participants stood on a sliding board (that was either locked and as such motionless or unlocked and as such free to move in the anterior-posterior direction) and performed fast bilateral arms flexion. Arm acceleration, bilateral electromyographic activity (EMG) of the trunk and lower extremity muscles and center of pressure (COP) displacements were recorded and analyzed within the intervals typical for the anticipatory (APAs) and compensatory (CPAs) postural adjustments...
December 28, 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/29323510/consensual-lay-profiles-of-narcissism-and-their-connection-to-the-five-factor-narcissism-inventory
#3
Joshua D Miller, Donald R Lynam, Lane Siedor, Michael Crowe, W Keith Campbell
Although there is evidence that experts agree on the traits that characterize narcissism, this agreement may be due, in part, to the influence of the operationalizations based on the American Psychiatric Association's series of Diagnostic and Statistical Manuals of Mental Disorders (American Psychiatric Association [APA], 1980, 1994, 2013). Because these trait descriptions are important in shaping conceptualizations and serving as empirical criteria for construct validation, we explored their generalizability...
January 2018: Psychological Assessment
https://www.readbyqxmd.com/read/29323509/five-factor-model-personality-disorder-scales-an-introduction-to-a-special-section-on-assessment-of-maladaptive-variants-of-the-five-factor-model
#4
R Michael Bagby, Thomas A Widiger
The Five-Factor Model (FFM) is a dimensional model of general personality structure, consisting of the domains of neuroticism (or emotional instability), extraversion versus introversion, openness (or unconventionality), agreeableness versus antagonism, and conscientiousness (or constraint). The FFM is arguably the most commonly researched dimensional model of general personality structure. However, a notable limitation of existing measures of the FFM has been a lack of coverage of its maladaptive variants...
January 2018: Psychological Assessment
https://www.readbyqxmd.com/read/29319506/bacterial-communities-from-the-arsenic-mine-in-z%C3%A5-oty-stok-sudety-mountains-poland
#5
Tomasz Cłapa, Dorota Narożna, Rafał Siuda, Andrzej Borkowski, Marek Selwet, Cezary J Mądrzak, Ewa Koźlecka
Investigations of bacterial communities and characterization of mineralogy of the environment in the Złoty Stok As-Au deposit were carried out. PXRD analysis revealed the presence of picropharmacolite as the most common secondary arsenic mineral in the mine. Total DNA was extracted from slime streams or slime biofilms samples to investigate the bacterial communities. PCR amplification of 16S rDNA was performed followed by subcloning of its products. Over 170 clones were analyzed by means of RFLP method. Eight group of clones representing different restriction patterns were identified...
September 27, 2017: Polish Journal of Microbiology
https://www.readbyqxmd.com/read/29318382/mir-29-silencing-modulates-the-expression-of-target-genes-related-to-proliferation-apoptosis-and-methylation-in-burkitt-lymphoma-cells
#6
Luciano Mazzoccoli, Marcela Cristina Robaina, Alexandre Gustavo Apa, Martin Bonamino, Luciana Wernersbach Pinto, Eduardo Queiroga, Carlos E Bacchi, Claudete Esteves Klumb
PURPOSE: Burkitt lymphoma (BL) is a B-cell lymphoma frequently diagnosed in children. It is characterized by MYC translocations, which lead to the constitutive expression of the MYC oncogene. MYC contributes to miR-29 repression through an E-box MYC binding site on the miR-29b-1/miR-29a promoter region. We evaluated the role of miR-29a/b/c and their predicted targets in BL pathogenesis. METHODS: Mature sequences of miR-29a/b/c were transfected to the BL cell lines BL41 and Raji, and evaluated for DNMT3B, MCL1, BIM, CDK6, AKT and TCL1 protein expression as well as for MCL-1 and CDK6 mRNA expression...
January 9, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29317937/evaluating-the-potential-for-pharmacists-to-prescribe-oral-anticoagulants-for-atrial-fibrillation
#7
Roopinder K Sandhu, Lisa M Guirguis, Tammy J Bungard, Erik Youngson, Lisa Dolovich, Jamie C Brehaut, Jeff S Healey, Finlay A McAlister
Background: Oral anticoagulant therapy (OAC) to prevent atrial fibrillation (AF)-related strokes remains poorly used. Alternate strategies, such as community pharmacist prescribing of OAC, should be explored. Methods: Approximately 400 pharmacists, half with additional prescribing authority (APA), randomly selected from the Alberta College of Pharmacists, were invited to participate in an online survey over a 6-week period. The survey consisted of demographics, case scenarios assessing appropriateness of OAC (based on the 2014 Canadian Cardiovascular Society AF guidelines) and perceived barriers to prescribing...
January 2018: Canadian Pharmacists Journal: CPJ, Revue des Pharmaciens du Canada: RPC
https://www.readbyqxmd.com/read/29309742/abnormal-repolarization-duration-during-everyday-emotional-arousal-in-long-qt-syndrome-and-coronary-artery-disease
#8
Richard D Lane, Harry T Reis, Chiu-Hsieh Hsu, Karl B Kern, Jean Philippe Couderc, Arthur J Moss, Wojciech Zareba
BACKGROUND: Rare high arousal negative emotions are known triggers of sudden death in individuals with preexisting heart disease. Whether everyday fluctuations in emotional arousal influence arrhythmia risk is unknown. METHODS: We studied 160 patients with the congenital Long QT Syndrome (LQTS), 199 patients with coronary artery disease, and two groups of matched healthy volunteers (n=53 and 50, respectively). Three-day home visits including a 12-hour Holter recording each day were completed...
January 5, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29307373/synthesis-and-evaluation-of-the-mutagenicity-of-3-alkylpyridine-marine-alkaloid-analogues-with-anticancer-potential
#9
Maria Cristina S Barbosa, Camila de Souza Barbosa, Júlia T de Oliveira, Natália Chermont S Moreira, Natália Rezende de Miranda Martins, Gabrielle K Alves Gomes, Camila A Caldeira, Marília Ladeira Alves E Costa, Daniel Silqueira Martins Guimarães, Luciana Guimarães, Clebio S Nascimento, Fernando de Pilla Varotti, Gustavo Henrique Ribeiro Viana, Fabio Vieira Dos Santos
Theonella sp is an important source of biologically-active 3-alkylpyridine alkaloids (3-APAs) that has shown a wide variety of promising biological effects. In the present work, two new 3-APAs analogues were synthesized based on molecular modeling studies to act as potential antimalarial agents. These theoneladin C analogues, containing the thiocyanate group in their chemical structures, were synthesized and evaluated against Plasmodium falciparum (IC50 values ranging from 2.3 to 5.5μM). The structural and energetic analysis demonstrated a high chemical affinity of the two analogues for their target, the heme group...
January 2018: Mutation Research
https://www.readbyqxmd.com/read/29306913/diagnosis-of-acute-pediatric-appendicitis-from-children-with-inflammatory-diseases-by-combination-of-metabolic-markers-and-inflammatory-response-variables
#10
Mengjie Yu, Tianxin Xiang, Xiaoping Wu, Shouhua Zhang, Wenlong Yang, Yu Zhang, Qiang Chen, Shuilin Sun, Baogang Xie
BACKGROUND: The discovery of new metabolic markers may be helpful for early diagnosis of acute pediatric appendicitis (APA). However, no studies have been reported regarding identification of potential metabolic markers for the APA diagnosis by metabonomics. METHODS: Serum samples of APA (n=32), non-appendicitis inflammation (NAI, n=32) and healthy children (HS, n=65) were analyzed by the 1H NMR-based metabonomics. A logistic regression model was established to screen the most efficient markers combinations for classification...
January 8, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29306067/maternal-ratings-of-odd-symptoms-subtypes-versus-severity-in-a-general-community-sample-of-children
#11
Rapson Gomez, Vasilis Stavropoulos
BACKGROUND AND AIMS: Oppositional Defiant Disorder (ODD) is a common childhood disorder (American Psychiatric Association [APA], 2000; APA, 2013). The aim of the present study was to ascertain the optimal structure for the ODD symptoms by identifying whether ODD is a qualitatively distinct entity (categorical) or is a continuum, with high levels on this continuum reflecting ODD (quantitative or dimensional view). METHODS: Mothers' ratings of the ODD symptoms of 457 children, aged 3 to 15years, as presented in the disruptive behavior rating scale were obtained...
December 8, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29305618/control-of-vertical-posture-while-standing-on-a-sliding-board-and-pushing-an-object
#12
Yun-Ju Lee, Bing Chen, Jing-Nong Liang, Alexander S Aruin
Voluntary pushing or translation perturbation of the support surface each induces a body perturbation that affects postural control. The objective of the study was to investigate anticipatory (APA) and compensatory (CPA) postural adjustments when pushing an object (that induces self-initiated perturbation) and standing on a sliding board (that induces translational perturbation). Thirteen healthy young participants were instructed to push a handle with both hands while standing on a sliding board that was either free to move in the anterior-posterior direction or stationary...
January 5, 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29303415/re-establishment-of-biocompatibility-of-the-in-vitro-contaminated-titanium-surface-using-osteoconductive-powders-with-air-abrasive-treatment
#13
Ceylin Sedef Tastepe, Xingnan Lin, Marcel Donnet, Behrouz Zandieh Doulabi, Daniel Wismeijer, Yuelian Liu
To achieve re-osseointegration on implant surfaces exposed to peri-implant infections, treatment should re-establish biocompatibility. The aim of this study was to test whether air powder abrasive treatment (APA) using osteoconductive powders can, in addition to cleaning, increase the biocompatibility of the contaminated implant surface. 96 in-vitro Ca-precipitated, organic-film-layer-coated SLA titanium discs were treated by APA using Erythritol, Hydroxylapatite (HA) and Biocalcium Phosphate (BioCaP) powders (n=16 per group)...
January 5, 2018: Journal of Oral Implantology
https://www.readbyqxmd.com/read/29296927/abo-blood-group-a-transferases-catalyze-the-biosynthesis-of-fors-blood-group-fors1-antigen-upon-deletion-of-exon-3-or-4
#14
Miyako Yamamoto, Emili Cid, Fumiichiro Yamamoto
Evolutionarily related ABO and GBGT1 genes encode, respectively, A and B glycosyltransferases (AT and BT) and Forssman glycolipid synthase (FS), which catalyze the biosynthesis of A and B, and Forssman (FORS1) oligosaccharide antigens responsible for the ABO and FORS blood group systems. Humans are a Forssman antigen-negative species; however, rare individuals with Apae phenotype express FORS1 on their red blood cells. We previously demonstrated that the replacement of the LeuGlyGly tripeptide sequence at codons 266 to 268 of human AT with GBGT1-encoded FS-specific GlyGlyAla enabled the enzyme to produce FORS1 antigen, although the FS activity was weak...
December 26, 2017: Blood Advances
https://www.readbyqxmd.com/read/29295989/amphiphilic-nanocarrier-induced-modulation-of-plk1-and-mir-34a-leads-to-improved-therapeutic-response-in-pancreatic-cancer
#15
Hadas Gibori, Shay Eliyahu, Adva Krivitsky, Dikla Ben-Shushan, Yana Epshtein, Galia Tiram, Rachel Blau, Paula Ofek, Joo Sang Lee, Eytan Ruppin, Limor Landsman, Iris Barshack, Talia Golan, Emmanuelle Merquiol, Galia Blum, Ronit Satchi-Fainaro
The heterogeneity of pancreatic ductal adenocarcinoma (PDAC) suggests that successful treatment might rely on simultaneous targeting of multiple genes, which can be achieved by RNA interference-based therapeutic strategies. Here we show a potent combination of microRNA and siRNA delivered by an efficient nanocarrier to PDAC tumors. Using proteomic-microRNA profiles and survival data of PDAC patients from TCGA, we found a novel signature for prolonged survival. Accordingly, we used a microRNA-mimic to increase miR-34a together with siRNA to silence PLK1 oncogene...
January 2, 2018: Nature Communications
https://www.readbyqxmd.com/read/29283666/international-humanitarian-award
#16
(no author information available yet)
The International Humanitarian Award recognizes extraordinary humanitarian services and activism by psychologists, including professional and volunteer work conducted primarily in the field with underserved populations. Award recipients are psychologists who, by their extraordinary service at a difficult time, improve the lives and contribute to the well-being of people in a large or small geographic area anywhere in the world. The 2017 recipient of the APA International Humanitarian Award was selected by the 2016 Committee on International Relations in Psychology (CIRP)...
December 2017: American Psychologist
https://www.readbyqxmd.com/read/29283663/award-for-distinguished-contributions-to-the-international-advancement-of-psychology
#17
(no author information available yet)
This award is given to individuals who have made sustained and enduring contributions to international cooperation and the advancement of knowledge in psychology. The 2017 recipient of the APA Award for Distinguished Contributions to the International Advancement of Psychology was selected by the 2016 Committee on International Relations in Psychology (CIRP). The members of the 2016 CIRP were Melissa Morgan Consoli, PhD, and Arpana G. Inman, PhD (Co-chairs); Rehman Abdulrehman, PhD; Gonzalo Bacigalupe, EdD; Frederic Bemak, EdD; Brigitte Khoury, PhD; Susan Nolan, PhD; Nancy Sidun, PsyD; and Danny Wedding, PhD...
December 2017: American Psychologist
https://www.readbyqxmd.com/read/29283662/apa-apags-award-for-distinguished-graduate-student-in-professional-psychology-octavio-andres-santos
#18
(no author information available yet)
The APA/APAGS Award for Distinguished Graduate Student in Professional Psychology is awarded annually by the APA Board of Professional Affairs (BPA) and the American Psychological Association of Graduate Students (APAGS) to a graduate student who has demonstrated outstanding practice and application of psychology. The 2017 award winner is Octavio Andres Santos, who has demonstrated through several initiatives "effective engagement with advocacy, professional organizations, and research in the area of health disparities and multicultural/multilingual assessment...
December 2017: American Psychologist
https://www.readbyqxmd.com/read/29283661/apa-apags-award-for-distinguished-graduate-student-in-professional-psychology
#19
(no author information available yet)
The APA/APAGS Award for Distinguished Graduate Student in Professional Psychology is awarded on an annual basis by the APA Board of Professional Affairs (BPA) and the American Psychological Association of Graduate Students (APAGS) to a graduate student who has demonstrated outstanding practice and application of psychology. A qualified candidate must demonstrate exemplary performance in working with an underserved population in an applied setting or have developed an innovative method for delivering health services to an underserved population...
December 2017: American Psychologist
https://www.readbyqxmd.com/read/29283659/award-for-distinguished-professional-contributions-to-institutional-practice-linda-r-mona
#20
(no author information available yet)
The APA Awards for Distinguished Professional Contributions to Institutional Practice are intended to recognize outstanding practitioners in institutional settings in psychology. The 2017 award winner is Linda R. Mona, whose treatment of veterans with disabilities has advanced treatment with respect to sexual health. Her clinical work and advocacy for psychology practice have received national recognition. Mona's award citation, biography, and a selected bibliography are presented here. (PsycINFO Database Record...
December 2017: American Psychologist
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