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https://www.readbyqxmd.com/read/29780778/impact-of-presence-of-antiphospholipid-antibodies-on-in-vitro-fertilization-outcome
#1
Yeon Hee Hong, Se Jeong Kim, Kyoung Yong Moon, Seul Ki Kim, Byung Chul Jee, Won Don Lee, Seok Hyun Kim
Objective: To investigate prevalence of antiphospholipid antibody (APA) in Korean infertile women undergoing the first in vitro fertilization (IVF) treatment and to evaluate the influence of APA on the subsequent IVF outcomes. Method: Two hundred nineteen infertile women who destined the first IVF were prospectively enrolled in 2 infertility centers. Male factor or uterine factor infertility and women with past or current endocrine or immunologic disorders were completely excluded...
May 2018: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/29780246/remineralization-potential-of-nano-hydroxyapatite-on-enamel-and-cementum-surrounding-margin-of-computer-aided-design-and-computer-aided-manufacturing-ceramic-restoration
#2
Niwut Juntavee, Apa Juntavee, Preeyarat Plongniras
Objective: This study investigates the effects of nano-hydroxyapatite (NHA) gel and Clinpro (CP) on remineralization potential of enamel and cementum at the cavosurface area of computer-aided design and computer-aided manufacturing ceramic restoration. Materials and methods: Thirty extracted human mandibular third molars were sectioned at 1 mm above and below the cemento-enamel junction to remove the cemento-enamel junction portions and replaced them with zirconia ceramic disks by bonding them to the crown and root portions with resin cement...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29780166/nudt21-negatively-regulates-psmb2-and-cxxc5-by-alternative-polyadenylation-and-contributes-to-hepatocellular-carcinoma-suppression
#3
Sheng Tan, Hua Li, Weijie Zhang, Yunying Shao, Yuan Liu, Haiyang Guan, Jun Wu, Yani Kang, Junsong Zhao, Qing Yu, Yunzhao Gu, Keshuo Ding, Min Zhang, Wenchang Qian, Yong Zhu, Huayong Cai, Changyu Chen, Peter E Lobie, Xiaodong Zhao, Jielin Sun, Tao Zhu
Alternative polyadenylation (APA) is an important post-transcriptional regulatory mechanism and involved in many diseases, including cancer. CFIm25, a subunit of the cleavage factor I encoded by NUDT21, is required for 3'RNA cleavage and polyadenylation. Although it has been recently reported to be involved in glioblastoma tumor suppression, its roles and the underlying functional mechanism remain unclear in other types of cancer. In this study, we characterized NUDT21 in hepatocellular carcinoma (HCC). Reduced expression of NUDT21 was observed in HCC tissue compared to adjacent non-tumorous compartment...
May 21, 2018: Oncogene
https://www.readbyqxmd.com/read/29777980/trunk-postural-adjustments-medium-term-reliability-and-correlation-with-changes-of-clinical-outcomes-following-an-8-week-lumbar-stabilization-exercise-program
#4
Jean-Alexandre Boucher, Richard Preuss, Sharon M Henry, Marilee Nugent, Christian Larivière
BACKGROUND: Low back pain (LBP) has been previously associated with delayed anticipatory postural adjustments (APAs) determined by trunk muscle activation. Lumbar stabilization exercise programs (LSEP) for patients with LBP may restore the trunk neuromuscular control of the lumbar spine, and normalize APAs. This exploratory study aimed at testing the reliability of EMG and kinematics-based postural adjustment measures over an 8-week interval, assessing their sensitivity to LBP status and treatment and examining their relationship with clinical outcomes...
April 22, 2018: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/29773519/the-neurosteroid-allopregnanolone-sulfate-inhibits-na-v-1-3-%C3%AE-subunit-containing-voltage-gated-sodium-channels-expressed-in-xenopus-oocytes
#5
Takafumi Horishita, Nobuyuki Yanagihara, Susumu Ueno, Dan Okura, Reiko Horishita, Tomoko Minami, Yuichi Ogata, Yuka Sudo, Yasuhito Uezono, Takashi Kawasaki
The neurosteroid allopregnanolone has potent analgesic effects, and its potential use for neuropathic pain is supported by recent reports. However, the analgesic mechanisms are obscure. The voltage-gated sodium channels (Nav ) α subunit Nav 1.3 is thought to play an essential role in neuropathic pain. Here, we report the effects of allopregnanolone sulfate (APAS) on sodium currents (INa ) in Xenopus oocytes expressing Nav 1.3 with β1 or β3 subunits. APAS suppressed INa of Nav 1.3 with β1 and β3 in a concentration-dependent manner (IC50 values; 75 and 26 μmol/L)...
March 30, 2018: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/29770148/clinical-characteristics-of-aldosterone-and-cortisol-coproducing-adrenal-adenoma-in-primary-aldosteronism
#6
Lu Tang, Xintao Li, Baojun Wang, Xin Ma, Hongzhao Li, Yu Gao, Liangyou Gu, Wenyuan Nie, Xu Zhang
Aldosterone- and cortisol-coproducing adrenal adenoma (A/CPA) cases have been observed in patients with primary aldosteronism (PA). This study investigated the incidence, clinical characteristics, and molecular biological features of patients with A/CPAs. We retrospectively identified 22 A/CPA patients from 555 PA patients who visited the Chinese People's Liberation Army General Hospital between 2004 and 2015. Analysis of clinical parameters revealed that patients with A/CPAs had larger tumors than those with pure APAs ( P < 0...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29764374/direct-measurement-of-pervasive-weak-repression-by-micrornas-and-their-role-at-the-network-level
#7
Fuqiang Ma, Pei Lin, Qingjian Chen, Xuemei Lu, Yong E Zhang, Chung-I Wu
BACKGROUND: A gene regulatory network (GRN) comprises many weak links that are often regulated by microRNAs. Since miRNAs rarely repress their target genes by more than 30%, doubts have been expressed about the biological relevance of such weak effects. These doubts raise the possibility of under-estimation as miRNA repression is usually estimated indirectly from equilibrium expression levels. RESULTS: To measure miRNA repression directly, we inhibited transcript synthesis in Drosophila larvae and collected time-course data on mRNA abundance, the decline of which reflects transcript degradation...
May 15, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29756580/subtypes-of-antiphospholipid-antibodies-in-neurologic-accidents-an-observational-study
#8
Maryam Sahebari, Maryam Rastin, Reza Boostani, Mohsen Forughipour, Kamila Hashemzadeh, Samira HaajSadeghi
OBJECTIVE: Until now, concomitant neurological manifestations and positive antiphospholipid antibodies (APA(s)) have been investigated in different manners. The most important conflicts in this field are whether those manifestations are directly related to APA(s) or not and treatment strategies. METHOD: In this study, adopting a different manner, we selected patients with a recently defined neurological problem (according to study protocol) and positive APA without any other risk factor, to compare types, amounts, and titer of APAs...
May 14, 2018: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/29753122/high-level-expression-and-glycosylation-of-recombinant-mycobacterium-tuberculosis-ala-pro-rich-antigen-in-pichia-pastoris
#9
Shengjun Wang, Yaoguang Wang, Peng George Wang, Min Chen, Yun Kong
The Ala-Pro-rich Antigen (Apa) from Mycobacterium tuberculosis is a mannosylated protein with immunogenic and antigenic properties. The O-mannosylation is essential for its biological function in the process of colonization and invasion of host cells by M. tuberculosis. In this work, the gene encoding Apa was cloned from M. tuberculosis and expressed in Pichia pastoris GS115. In shake-flasks, the recombinant Apa was secreted into the culture media and purified with a yield of 0.6 g/L. Both N- and O-glycans were found in recombinant Apa...
May 9, 2018: Protein Expression and Purification
https://www.readbyqxmd.com/read/29745627/neurophysiological-and-clinical-effects-of-blinfolded-balance-training-bbt-in-parkinson-s-disease-patients-a-preliminary-study
#10
Sonia Bonnì, Viviana Ponzo, Marco Tramontano, Alex Martino Cinnera, Carlo Caltagirone, Giacomo Koch, Antonella Peppe
BACKGROUND: Recent evidence support the hypothesis that rehabilitative strategies based on sensorimotor stimulation in the neurorehabilitation of Parkinson's Disease (PD) may be useful to improve gait in PD patients. AIM: We supposed that sensorimotor stimulation produce modulation of Anticipatory Postural Adjustments (APAs) arising from the supplementary motor area (SMA). We aimed to investigate the clinical and neurophysiological effects of a blindfolded balance training (BBT)...
May 9, 2018: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29744212/cleaning-effect-of-osteoconductive-powder-abrasive-treatment-on-explanted-human-implants-and-biofilm-coated-titanium-discs
#11
Ceylin S Tastepe, Xingnan Lin, Arie Werner, Marcel Donnet, Daniel Wismeijer, Yuelian Liu
The aim of this study is to test the cleaning effect and surface modification of a new implant surface treatment on explanted dental implants and titanium discs. It is a modified air powder abrasive (APA) treatment applied using osteoconductive powders. Twenty-eight in vitro Ca-precipitated organic film-coated titanium discs and 13 explanted dental implants were treated. In a 2-step approach, 3 powders were used: hydroxylapatite (HA) and biomimetic calcium phosphate (BioCaP), which are osteoconductive, and erythritol, which is not...
February 2018: Clinical and Experimental Dental Research
https://www.readbyqxmd.com/read/29742971/insufficiency-of-the-zona-glomerulosa-of-the-adrenal-cortex-and-progressive-kidney-insufficiency-following-unilateral-adrenalectomy-case-report-and-discussion
#12
Joanna Kanarek-Kucner, Adrian Stefański, Rufus Barraclough, Tomasz Gorycki, Jacek Wolf, Krzysztof Narkiewicz, Michał Hoffmann
BACKGROUND: Primary aldosteronism (PA) is the most common cause of secondary hypertension and bilateral adrenal hyperplasia (BAH) and aldosterone-producing adenoma (APA) seem to be the most common causes of PA. Unilateral adrenalectomy (UA) is the preferred treatment for APA, although the benefits are still difficult to assess. CASE REPORT: We present a case report of a 69-year old man with a 30 year history of hypertension and probably long-standing PA due to APA, with typical organ complications...
May 9, 2018: Blood Pressure
https://www.readbyqxmd.com/read/29741297/a-pedunculated-aldosterone-producing-adenoma-drained-by-an-extra-vein-causing-puzzling-results-of-adrenal-vein-sampling
#13
Marieke S Velema, Tanja Dekkers, Ad R M M Hermus, Henri J L M Timmers, Johan Langenhuijsen, Mark Arntz, Benno Kusters, Graeme Eisenhofer, Jacques W M Lenders, Jaap Deinum
Primary aldosteronism (PA) is a common cause of endocrine hypertension in which two main subtypes are distinguished: bilateral adrenal hyperplasia (BAH) and aldosterone-producing adenomas (APA).1 Computed tomography (CT) and adrenal vein sampling (AVS) are used to differentiate between these subtypes. There are two basic conditions for AVS. First, aldosterone concentrations should be corrected for peripheral blood admixture by normalizing for cortisol concentration. Second, it is assumed that either adrenal is drained by one vein...
May 9, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29740637/a-randomized-efficacy-trial-of-a-cognitive-behavioral-group-intervention-to-prevent-internet-use-disorder-onset-in-adolescents-the-protect-study-protocol
#14
Katajun Lindenberg, Katharina Halasy, Sophie Schoenmaekers
Background: The reduction of prevalence rates of Internet Use Disorder (IUD) and its effective treatment are at high priority in both public health and educational policies. School-based preventive interventions facilitate a low-threshold approach for individuals with IUD, who are typically characterized by high therapy avoidance. Moreover, indicated approaches which target adolescents at high-risk show larger effects than universal prevention programs. Simultaneously, they reduce unnecessary burden for the majority of high-school students that is not at-risk...
June 2017: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/29737263/glucose-lowering-activity-of-the-aqueous-extract-of-warionia-saharae-in-normal-and-diabetic-rats
#15
Mohamed Eddouks, Morad Hebi
The current study was carried out to investigate the effect of a single dose and daily oral administration for 15 days of the aerial part aqueous extract (A.P.A.E) of Warionia saharae (W. saharae) at a dose of 5 mg/kg body weight on blood glucose levels and the histopathological changes in liver and pancreas both in normal and streptozotocin-induced diabetic rats (STZ). Also, the effect of this extract to improve glucose tolerance in normal rats was demonstrated. Single oral administration of W. saharae A.P...
April 25, 2018: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29733382/an-integrative-model-for-alternative-polyadenylation-intmap-delineates-mtor-modulated-endoplasmic-reticulum-stress-response
#16
Jae-Woong Chang, Wei Zhang, Hsin-Sung Yeh, Meeyeon Park, Chengguo Yao, Yongsheng Shi, Rui Kuang, Jeongsik Yong
3'-untranslated regions (UTRs) can vary through the use of alternative polyadenylation sites during pre-mRNA processing. Multiple publically available pipelines combining high profiling technologies and bioinformatics tools have been developed to catalog changes in 3'-UTR lengths. In our recent RNA-seq experiments using cells with hyper-activated mammalian target of rapamycin (mTOR), we found that cellular mTOR activation leads to transcriptome-wide alternative polyadenylation (APA), resulting in the activation of multiple cellular pathways...
May 4, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29727218/activated-no-pathway-in-uterine-arteries-during-pregnancy-in-iugr-rat-model
#17
Emilie Bigonnesse, Benoit Sicotte, Michele Brochu
Insufficient development of the utero-placental circulation may contribute to the development of intrauterine growth restriction (IUGR). We developed a rat model of IUGR by administering a low-sodium diet. This diet reduces maternal blood volume expansion and uteroplacental perfusion. We hypothesized that an impaired endothelial function in radial arteries decreases vasorelaxation and lowers placental perfusion in this IUGR model. The objective was to assess radial uterine artery responses to vasoactive agents in the IUGR model, versus controls...
May 4, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29726953/genetic-characterization-of-gnrh-lh-responsive-primary-aldosteronism
#18
Nadia Gagnon, Katia Caceres, Gilles Corbeil, Nada El Ghorayeb, Natasha Ludwig, Mathieu Latour, André Lacroix, Isabelle Bourdeau
Background: Recently, somatic beta-catenin mutations (CTNNB1) identified in aldosterone-producing adenomas (APA) from 3 women, were suggested to be responsible for the aberrant overexpression of LHCGR and GNRHR in the APA. Objective: To genetically characterize patients with primary aldosteronism (PA) evaluated in vivo for GnRH/LH responsive aldosterone secretion. Method: Patients with PA were evaluated in vivo to determine the possible regulation of aldosterone secretion by GnRH or LH...
May 2, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29717174/cell-cycle-regulation-by-alternative-polyadenylation-of-ccnd1
#19
Qiong Wang, Guopei He, Mengmeng Hou, Liutao Chen, Shangwu Chen, Anlong Xu, Yonggui Fu
Global shortening of 3'UTRs by alternative polyadenylation (APA) has been observed in cancer cells. However, the role of APA in cancer remains unknown. CCND1 is a proto-oncogene that regulates progression through the G1-S phase of the cell cycle; moreover, it has been observed to be switching to proximal APA sites in cancer cells. To investigate the biological function of the APA of CCND1, we edited the weak poly(A) signal (PAS) of the proximal APA site to a canonical PAS using the CRISPR/Cas9 method, which can force the cells to use a proximal APA site...
May 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29712909/widespread-intronic-polyadenylation-diversifies-immune-cell-transcriptomes
#20
Irtisha Singh, Shih-Han Lee, Adam S Sperling, Mehmet K Samur, Yu-Tzu Tai, Mariateresa Fulciniti, Nikhil C Munshi, Christine Mayr, Christina S Leslie
Alternative cleavage and polyadenylation (ApA) is known to alter untranslated region (3'UTR) length but can also recognize intronic polyadenylation (IpA) signals to generate transcripts that lose part or all of the coding region. We analyzed 46 3'-seq and RNA-seq profiles from normal human tissues, primary immune cells, and multiple myeloma (MM) samples and created an atlas of 4927 high-confidence IpA events represented in these cell types. IpA isoforms are widely expressed in immune cells, differentially used during B-cell development or in different cellular environments, and can generate truncated proteins lacking C-terminal functional domains...
April 30, 2018: Nature Communications
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