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https://www.readbyqxmd.com/read/27911321/the-effects-of-meditation-on-grey-matter-atrophy-and-neurodegeneration-a%C3%A2-systematic-review
#1
Nicole Last, Emily Tufts, Leslie E Auger
The present systematic review is based on the premise that a variety of neurodegenerative diseases are accompanied by grey matter atrophy in the brain and meditation may impact this. Given that age is a major risk factor for many of these progressive and neurodegenerative diseases and that the percentage of the population over the age of 65 is quickly increasing, there is an obvious need for prompt treatment and prevention advances in research. As there is currently no cure for Alzheimer's disease and other neurodegenerative diseases, many are seeking non-pharmacological treatment options in attempts to offset the disease-related cognitive and functional declines...
November 26, 2016: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/27901181/evaluation-of-preoperative-ultrasonographic-and-biochemical-features-of-patients-with-aggressive-parathyroid-disease-is-there-a-reliable-predictive-marker
#2
Bekir Cakir, Sefika Burcak Polat, Mehmet Kilic, Didem Ozdemir, Cevdet Aydin, Nuran Süngü, Reyhan Ersoy
Objective: Parathyroid cancer (PC) represents < 1% of cases of PHPT. Tumors demonstrating atypical histopathologic features and don't fulfill criteria for carcinoma are classified as atypical adenomas (APA). The purpose of this study was to determine a biochemical or ultrasonographic feature that can predict aggressive disease requiring more extensive surgery and closer follow-up. Subjects and methods: Twenty eight patients operated for PHPT and diagnosed with atypical adenoma (23 patients) or carcinoma (5 patients) were enrolled in this study...
November 24, 2016: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27898276/behind-the-mask-a-psychodynamic-exploration-of-the-experiences-of-individuals-diagnosed-with-social-anxiety-disorder
#3
Beth McEvoy, John O'Connor, Odhran McCarthy
The diagnostic category of social anxiety disorder (SAD) is one that is widely drawn upon in mental health settings; SAD is primarily characterized by a marked fear of social performance situations and possible scrutiny by other people (American Psychiatric Association [APA], 1994, 2013). The current study aims to explore the experiences of people diagnosed with SAD. Psychoanalytically informed research interviews, drawing on psychoanalytic ideas around the parameters of engagement and levels of engagement and analysis, were carried out with 4 male and 2 female participants with diagnoses of SAD...
2016: Psychodynamic Psychiatry
https://www.readbyqxmd.com/read/27896569/anti-pituitary-antibodies-against-corticotrophs-in-igg4-related-hypophysitis
#4
Naoko Iwata, Shintaro Iwama, Yoshihisa Sugimura, Yoshinori Yasuda, Kohtaro Nakashima, Seiji Takeuchi, Daisuke Hagiwara, Yoshihiro Ito, Hidetaka Suga, Motomitsu Goto, Ryoichi Banno, Patrizio Caturegli, Teruhiko Koike, Yoshiharu Oshida, Hiroshi Arima
PURPOSE: IgG4-related disease is a systemic inflammatory disease characterized by infiltration of IgG4-positive plasma cells into multiple organs, including the pituitary gland. Autoimmunity is thought to be involved in the pathogenesis of IgG4-related disease. The diagnosis of IgG4-related hypophysitis (IgG4-RH) is difficult because its clinical features, such as pituitary swelling and hypopituitarism, are similar to those of other pituitary diseases, including lymphocytic hypophysitis and sellar/suprasellar tumors...
November 28, 2016: Pituitary
https://www.readbyqxmd.com/read/27893352/prevalence-of-antibodies-to-a-new-histo-blood-system-the-fors-system
#5
Carlos Jesus, Camilla Hesse, Clara Rocha, Nádia Osório, Ana Valado, Armando Caseiro, António Gabriel, Lola Svensson, Ali-Reza Moslemi, Wafa Abu Siba, Mahmoud A Srour, Cristina Pereira, Jorge Tomaz, Paulo Teixeira, Fernando Mendes
BACKGROUND: In 1987, three unrelated English families were reported with a putative blood subgroup called Apae. Swedish researchers later found evidence leading to abolishment of the Apae subgroup and establishment instead of the FORS blood group system (System 31 - ISBT, 2012). It is important to know the prevalence of antibodies in order to make the best decisions in transfusion medicine. Cells expressing the Forssman saccharide, such as sheep erythrocytes, are needed to detect the anti-Forssman antibody...
October 24, 2016: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/27887884/calcium-phosphate-nanoparticles-functionalized-with-alendronate-conjugated-polyethylene-glycol-peg-for-the-treatment-of-bone-metastasis
#6
Weijing Chu, Yanjuan Huang, Chanzhen Yang, Yunhui Liao, Xuefei Zhang, Mina Yan, Shengmiao Cui, Chunshun Zhao
Because of the peculiarity of the bone microstructure, the uptake of chemotherapeutics often happens at non-targeted sites, which induces side effects. In order to solve this problem, we designed a bone-targeting drug delivery system that can release drug exclusively in the nidus of the bone. Alendronate (ALN), which has a high ability to target to hydroxyapatite, was used to fabricate double ALN-conjugated poly (ethylene glycol) 2000 material (ALN-PEG2k-ALN). The ALN-PEG2k-ALN was characterized using (1)H NMR and (31)P NMR and FTIR...
November 22, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27884524/increasing-phytoplankton-available-phosphorus-and-inhibition-of-macrophyte-on-phytoplankton-bloom
#7
Yanran Dai, Juan Wu, Xiaohang Ma, Fei Zhong, Naxin Cui, Shuiping Cheng
We assembled mesocosms to address the coherent mechanisms that an increasing phosphorus (P) concentration in water columns coupled with the phytoplankton bloom and identify the performance gap of regulating phytoplankton growth between two macrophyte species, Ceratophyllum demersum L. and Vallisneria spiralis L. Intense alkaline phosphatase activities (APA) were observed in the unplanted control, with their predominant part, phytoplankton APA (accounting for up to 44.7% of the total APA), and another large share, bacterial APA...
November 22, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27881058/relationship-between-systemic-lupus-erythematosus-activity-and-persistent-positive-antiphospholipid-antibodies
#8
Zhaleh Shariati Sarabi, Maryam Sahebari, Ali Etemad Rezaie, Mohammadtaghi Norouzi, Kamila Hashemzadeh
Systemic Lupus Erythematosus (SLE) is an autoimmune disorder, characterized by producing different auto-antibodies and multiorgan involvements. In this study we aimed to investigate the relationship between SLE activity and persistently positive antiphospholipid antibodies. Fifty-nine lupus patients (55 women and 4 men) who were assessed in two consecutive visits with 6 weeks interval were selected. Patients` clinical and laboratory data and serum antiphospholipid antibodies` values, were collected. Serum anticardiolipin antibodies and lupus anticoagulant were measured in two visits...
November 22, 2016: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/27866261/anticipatory-postural-adjustments-and-anticipatory-synergy-adjustments-preparing-to-a-postural-perturbation-with-predictable-and-unpredictable-direction
#9
Daniele Piscitelli, Ali Falaki, Stanislaw Solnik, Mark L Latash
We explored two aspects of feed-forward postural control, anticipatory postural adjustments (APAs) and anticipatory synergy adjustments (ASAs) seen prior to self-triggered unloading with known and unknown direction of the perturbation. In particular, we tested two main hypotheses predicting contrasting changes in APAs and ASAs. The first hypothesis predicted no major changes in ASAs. The second hypothesis predicted delayed APAs with predominance of co-contraction patterns when perturbation direction was unknown...
November 19, 2016: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/27862274/risk-of-fracture-in-primary-aldosteronism-a-population-based-cohort-study
#10
Vin-Cent Wu, Chia-Hui Chang, Cheng-Yi Wang, Yen-Hung Lin, Tze-Wah Kao, Po-Chih Lin, Tzong-Shinn Chu, Yuan-Shian Chang, Likwang Chen, Kwan-Dun Wu, Shih-Chieh Jeff Chueh
Primary aldosteronism (PA) is associated with increased urinary calcium excretion and osteoporosis prevalence. We studied the long-term effect of hyperaldosterone on fracture risk and possible risk mitigation via treatments, by comparing PA patients and their essential hypertension (EH) counterparts extracted by propensity score match. We used a longitudinal population database from the Taiwan National Health Insurance, and used a validated algorithm to identify PA patients diagnosed in 1997-2010. Our sample included 2533 PA patients, including 921 patients with aldosterone-producing adenoma (APA)...
November 10, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/27857837/autoimmune-polyendocrinopathy-and-hypophysitis-after-puumala-hantavirus-infection
#11
Marlene Tarvainen, Satu Mäkelä, Jukka Mustonen, Pia Jaatinen
: Puumala hantavirus (PUUV) infection causes nephropathia epidemica (NE), a relatively mild form of haemorrhagic fever with renal syndrome (HFRS). Hypophyseal haemorrhage and hypopituitarism have been described in case reports on patients with acute NE. Chronic hypopituitarism diagnosed months or years after the acute illness has also been reported, without any signs of a haemorrhagic aetiology. The mechanisms leading to the late-onset hormonal defects remain unknown. Here, we present a case of NE-associated autoimmune polyendocrinopathy and hypopituitarism presumably due to autoimmune hypophysitis...
2016: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/27853054/expression-of-cyp11b2-in-aldosterone-producing-adrenocortical-adenoma-regulatory-mechanisms-and-clinical-significance
#12
Yasuhiro Nakamura, Yuto Yamazaki, Yuta Tezuka, Fumitoshi Satoh, Hironobu Sasano
Aldosterone-producing adrenocortical adenoma (APA) is responsible for the majority of cases clinically diagnosed as primary aldosteronism. Aldosterone synthase (CYP11B2) is one of the enzymes that play essential roles in aldosterone synthesis and is involved in the pathogenesis of APA. Recent studies have demonstrated that various factors and regulators influence the expression and function of CYP11B2 in APA. In particular, somatic mutations, such as gain-of-function and loss-of-function mutations, have been identified in several genes, each of which encodes a pivotal protein that affects the calcium signaling pathway, the expression of CYP11B2, and aldosterone production...
2016: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27852495/defining-the-differences-in-transverse-plane-trajectories-for-thoracic-pedicle-screw-insertion-anatomic-versus-medial
#13
William R Hotchkiss, Richard M Schwend, Patrick P Bosch, Heather J H Edgar, Bonnie N Young
STUDY DESIGN: Comparing thoracic pedicle screw trajectories, screw lengths, and starting points by examining osteologic specimens. OBJECTIVE: Describe a medial screw trajectory (MST) compared to a screw trajectory along the anatomic pedicle angle (APA) in terms of trajectory, screw length, and starting point. SUMMARY OF BACKGROUND DATA: Although thoracic pedicle screw insertion is commonly used for posterior fusion and instrumentation, there is little data to quantify an MST that avoids the great vessels and allows for greater screw purchase...
January 2016: Spine Deformity
https://www.readbyqxmd.com/read/27847987/the-side-of-chronic-low-back-pain-matters-evidence-from-the-primary-motor-cortex-excitability-and-the-postural-adjustments-of-multifidi-muscles
#14
Hugo Massé-Alarie, Louis-David Beaulieu, Richard Preuss, Cyril Schneider
Hemispheric lateralization of pain processing was reported with overactivation of the right frontal lobe. Specifically in chronic low back pain (CLBP), functional changes in the left primary motor cortex (M1) with impaired anticipatory postural activation (APA) of trunk muscles have been observed. Given the connections between frontal and M1 areas for motor planning, it is hypothesized that the pain side could differently influence M1 function and APA of paravertebral multifidus (MF) muscles. This study aimed at testing whether people with right- versus left-sided CLBP showed different M1 excitability and APA...
November 15, 2016: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/27836806/hypometric-anticipatory-postural-adjustments-in-dystonia-are-not-affected-by-deep-brain-stimulation-of-globus-pallidus-internus
#15
Gregor Brecl Jakob, Olena Pelykh, Annika Plate, Zuzana Košutzká, Zvezdan Pirtošek, Maja Trošt, Joseph Ilmberger, Peter Valkovic, Jan H Mehrkens, Kai Bötzel
BACKGROUND: Dystonia is a movement disorder with patterned, directional, and often sustained muscle contractions that produce abnormal postures or repetitive movements. Deep brain stimulation (DBS) of the globus pallidus internus (GPi) is an effective and safe treatment for medically refractory dystonia. However, recent studies reported gait problems, gait freezing and falls in patients treated with DBS. Because these symptoms may point to deficient gait initiation processes, we systematically assessed the anticipatory postural adjustments (APAs) prior to stepping in dystonia patients with GPi-DBS...
November 9, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27835054/subcritical-water-oxidation-of-6-aminopenicillanic-acid-and-cloxacillin-using-h2o2-k2s2o8-and-o2
#16
Erdal Yabalak, H Ali Döndaş, Ahmet Murat Gizir
This study was undertaken to investigate the degradation of 6-aminopenicillanic acid (6-APA) and cloxacillin in aqueous solution by the combined effect of subcritical water and the oxidising agents O2, H2O2, and K2S2O8. Nano ZnO was used as a solid catalyst. Response surface methodology was used to determine the optimum experimental parameters (temperature, treatment time, and concentration of oxidising agent). For 6-APA, the maximum organic carbon (TOC) removal rates of 83.54%, 81.11% and 42.42% were obtained using H2O2, K2S2O8, and O2, respectively...
November 11, 2016: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/27834080/cardiac-dysfunction-in-association-with-increased-inflammatory-markers-in-primary-aldosteronism
#17
Jung Soo Lim, Sungha Park, Sung Il Park, Young Taik Oh, Eunhee Choi, Jang Young Kim, Yumie Rhee
BACKGROUND: Oxidative stress in primary aldosteronism (PA) is thought to worsen aldosterone-induced damage by activating proinflammatory processes. Therefore, we investigated whether inflammatory markers associated with oxidative stress is increased with negative impacts on heart function as evaluated by echocardiography in patients with PA. METHODS: Thirty-two subjects (mean age, 50.3±11.0 years; 14 males, 18 females) whose aldosterone-renin ratio was more than 30 among patients who visited Severance Hospital since 2010 were enrolled...
November 3, 2016: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27831692/a-quantitative-and-qualitative-evaluation-of-trainee-opinions-of-four-methods-of-personality-disorder-diagnosis
#18
Sharon M Nelson, Steven K Huprich, Sneha Shankar, Aimee Sohnleitner, Amy V Paggeot
Four methods of how to assess and diagnose personality disorders have received much attention within the literature: the Shedler-Westen Assessment Procedure (Shedler & Westen, 1998), the DSM-5 Section III Personality Disorders section (APA, 2011), the DSM-5 Section III trait model (APA, 2013), and the Psychodynamic Diagnostic Manual (PDM; PDM Task Force, 2006) descriptions of 15 personality disorders. Given that much of the debate has been driven by clinician concerns, it is important to consider clinical utility when evaluating the usefulness of each method...
November 10, 2016: Personality Disorders
https://www.readbyqxmd.com/read/27819464/toward-validation-of-a-structural-approach-to-conceptualizing-psychopathology-a-special-section-of-the-journal-of-abnormal-psychology
#19
Robert F Krueger, Jennifer L Tackett, Angus MacDonald
Traditionally, psychopathology has been conceptualized in terms of polythetic categories derived from committee deliberations and enshrined in authoritative psychiatric nosologies-most notably the Diagnostic and Statistical Manual of Mental Disorders (DSM; American Psychiatric Association [APA], 2013). As the limitations of this form of classification have become evident, empirical data have been increasingly relied upon to investigate the structure of psychopathology. These efforts have borne fruit in terms of an increasingly consistent set of psychopathological constructs closely connected with similar personality constructs...
November 2016: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/27816900/gait-initiation-is-impaired-in-subjects-with-parkinson-s-disease-in-the-off-state-evidence-from-the-analysis-of-the-anticipatory-postural-adjustments-through-wearable-inertial-sensors
#20
Gianluca Bonora, Martina Mancini, Ilaria Carpinella, Lorenzo Chiari, Fay B Horak, Maurizio Ferrarin
People with Parkinson's disease (PD) typically demonstrate impaired anticipatory postural adjustments (APAs) that shift the body center of mass forward (imbalance) and over the stance leg (unloading) prior to gait initiation. APAs are known to be smallest when people with PD are in their OFF-medication state compared to ON-medication or healthy controls. The aim of this pilot study is to validate a previously developed method for the assessment of gait initiation on PD patients in OFF state with body-worn, inertial sensors...
October 31, 2016: Gait & Posture
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