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https://www.readbyqxmd.com/read/28923661/the-influence-of-the-aquatic-environment-on-the-center-of-pressure-impulses-and-upper-and-lower-trunk-accelerations-during-gait-initiation
#1
Andresa R Marinho-Buzelli, Kei Masani, Hossein Rouhani, Ana M Barela, Gustavo T B Fernandes, Mary C Verrier, Milos R Popovic
Gait initiation is defined as the transition from stationary standing to steady-state walking. Despite the frequent use of therapy pools for training walking in early stages of rehabilitation, none have been reported on the effects of immersion on gait initiation. We aimed to analyze the center of pressure (COP) trajectories, the vertical and anteroposterior impulses and upper and lower trunk accelerations during anticipatory (APA) and execution phases of gait initiation. In the COP trajectory, the execution (EXE) phase was further subdivided in two phases: predominantly mediolateral (EXE1), and predominantly anteroposterior (EXE2)...
September 8, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28923027/aesthetic-principles-access-thyroidectomy-produces-the-best-cosmetic-outcomes-as-assessed-using-the-patient-and-observer-scar-assessment-scale
#2
Xiao Ma, Qi-Jun Xia, Guojun Li, Tian-Xiao Wang, Qin Li
BACKGROUND: Thyroid carcinoma (TC) is more likely to occur in young women. The aim of this study was to compare the aesthetic effect of different thyroidectomies. METHODS: One hundred twenty female patients who underwent thyroidectomy were evenly distributed into three groups: conventional access (CA), aesthetic principles access (APA) and minimally invasive access (MIA). The Patient and Observer Scar Assessment Scale (POSAS) was used as the assessment tool for the linear scar...
September 18, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28917912/a-plant-based-reactive-ammonium-phytate-for-use-as-a-flame-retardant-for-cotton-fabric
#3
Yajuan Feng, Yang Zhou, Daikun Li, Shuai He, Fengxiu Zhang, Guangxian Zhang
A plant-based non-formaldehyde flame retardant containing high phosphorus ammonium phytate (APA) was synthesized for cotton fabric. The char length of treated cotton sample decreased to 31mm from the original 300mm. The LOI value of finished cotton fabric was as high as 43.2%, and after 30 laundering cycles, it still remained 30.5%, suggesting that APA could be used as an effective semi-durable flame retardant. The TG analysis in air demonstrated that the thermal oxidation stability of treated fabric was significantly improved...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28916539/comparative-analysis-of-alternative-polyadenylation-in-s-cerevisiae-and-s-pombe
#4
Xiaochuan Liu, Mainul Hoque, Marc Larochelle, Jean-François Lemay, Nathan Yurko, James L Manley, François Bachand, Bin Tian
Alternative polyadenylation (APA) is a widespread mechanism that generates mRNA isoforms with distinct properties. Here we have systematically mapped and compared cleavage and polyadenylation sites (PASs) in two yeast species, S. cerevisiae and S. pombe Although >80% of the mRNA genes in each species were found to display APA, S. pombe showed greater 3' UTR size differences among APA isoforms than did S. cerevisiae PASs in different locations of gene are surrounded with distinct sequences in both species and are often associated with motifs involved in the Nrd1-Nab3-Sen1 termination pathway...
September 15, 2017: Genome Research
https://www.readbyqxmd.com/read/28912168/alternative-polyadenylation-of-prelid1-regulates-mitochondrial-ros-signaling-and-cancer-outcomes
#5
Austin E Gillen, Heather M Brechbuhl, Tomomi M Yamamoto, Enos C Kline, Manoj Pillai, Jay Hesselberth, Peter Kabos
Disruption of post-transcriptional gene regulation is a critical step in oncogenesis that can be difficult to observe using traditional molecular techniques. To overcome this limitation, a modified polyadenylation site sequencing (PAS-seq) protocol was used to generate a genome-wide map of alternative polyadenylation (APA) events in human primary breast tumor specimens and matched normal tissue. This approach identified an APA event in the PRELID1 mRNA that enhances its steady state level and translational efficiency, and is a strong breast cancer subtype-dependent predictor of patient clinical outcomes...
September 14, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28911119/a-snorna-modulates-mrna-3-end-processing-and-regulates-the-expression-of-a-subset-of-mrnas
#6
Chunliu Huang, Junjie Shi, Yibin Guo, Weijun Huang, Shanshan Huang, Siqi Ming, Xingui Wu, Rui Zhang, Junjun Ding, Wei Zhao, Jie Jia, Xi Huang, Andy Peng Xiang, Yongsheng Shi, Chengguo Yao
mRNA 3' end processing is an essential step in gene expression. It is well established that canonical eukaryotic pre-mRNA 3' processing is carried out within a macromolecular machinery consisting of dozens of trans-acting proteins. However, it is unknown whether RNAs play any role in this process. Unexpectedly, we found that a subset of small nucleolar RNAs (snoRNAs) are associated with the mammalian mRNA 3' processing complex. These snoRNAs primarily interact with Fip1, a component of cleavage and polyadenylation specificity factor (CPSF)...
September 6, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28911096/distinct-regulation-of-alternative-polyadenylation-and-gene-expression-by-nuclear-poly-a-polymerases
#7
Weimin Li, Wencheng Li, Rakesh S Laishram, Mainul Hoque, Zhe Ji, Bin Tian, Richard A Anderson
Polyadenylation of nascent RNA by poly(A) polymerase (PAP) is important for 3' end maturation of almost all eukaryotic mRNAs. Most mammalian genes harbor multiple polyadenylation sites (PASs), leading to expression of alternative polyadenylation (APA) isoforms with distinct functions. How poly(A) polymerases may regulate PAS usage and hence gene expression is poorly understood. Here, we show that the nuclear canonical (PAPα and PAPγ) and non-canonical (Star-PAP) PAPs play diverse roles in PAS selection and gene expression...
September 6, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28910620/ctag-paperclip-reveals-alternative-polyadenylation-promotes-cell-type-specific-protein-diversity-and-shifts-araf-isoforms-with-microglia-activation
#8
Hun-Way Hwang, Yuhki Saito, Christopher Y Park, Nathalie E Blachère, Yoko Tajima, John J Fak, Ilana Zucker-Scharff, Robert B Darnell
Alternative polyadenylation (APA) is increasingly recognized to regulate gene expression across different cell types, but obtaining APA maps from individual cell types typically requires prior purification, a stressful procedure that can itself alter cellular states. Here, we describe a new platform, cTag-PAPERCLIP, that generates APA profiles from single cell populations in intact tissues; cTag-PAPERCLIP requires no tissue dissociation and preserves transcripts in native states. Applying cTag-PAPERCLIP to profile four major cell types in the mouse brain revealed common APA preferences between excitatory and inhibitory neurons distinct from astrocytes and microglia, regulated in part by neuron-specific RNA-binding proteins NOVA2 and PTBP2...
September 13, 2017: Neuron
https://www.readbyqxmd.com/read/28893861/adrenal-venous-sampling-for-primary-aldosteronism-laboratory-medicine-best-practice
#9
Gregory Kline, Daniel T Holmes
Primary aldosteronism (PA) is the most common form of secondary hypertension and is critical to identify because when caused by an aldosterone-producing adenoma (APA) or another unilateral form, it is potentially curable, and even when caused by bilateral disease, antihypertensives more specific to PA treatment can be employed (ie, aldosterone antagonists). Identification of unilateral forms is not generally accomplished with imaging because APAs may be small and elude detection, and coincidental identification of a non-functioning incidentaloma contralateral to an APA may lead to removal of an incorrect gland...
September 11, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28893147/the-polish-version-of-the-michigan-hand-outcomes-questionnaire-cross-cultural-adaptation-reliability-construct-validity-and-measurement-error
#10
Mateusz Koziej, Marek Trybus, Anna Mydłowska, Kinga Sałapa, Maksymilian Gniadek, Marta Banach, Jarosław Brudnicki
The aims of this study were to translate the Michigan Hand Outcomes Questionnaire into the Polish language and to test the measurement properties of its quality criteria. A total of 120 patients with hand complaints completed the Polish Michigan Hand Outcomes Questionnaire and the Disabilities of the Arm, Shoulder, and Hand questionnaire on the first assessment, along with the grip test, pinch test, and pain sore assessed using a visual analogue scale during activity. After 7 days, 76 patients completed the Michigan Hand Outcomes Questionnaire the second time...
January 1, 2017: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/28891930/vitamin-d-receptor-gene-polymorphisms-associated-with-childhood-autism
#11
Anna Cieślińska, Elżbieta Kostyra, Barbara Chwała, Małgorzata Moszyńska-Dumara, Ewa Fiedorowicz, Małgorzata Teodorowicz, Huub F J Savelkoul
BACKGROUND: Autism spectrum disorder (ASD) is a group of heterogeneous, behaviorally defined disorders whereby currently no biological markers are common to all affected individuals. A deregulated immune response may be contributing to the etiology of ASD. The active metabolite of vitamin D₃ has an immunoregulatory role mediated by binding to the vitamin D receptor (VDR) in monocyte, macrophages, and lymphocytes. The effects of vitamin D and interaction with the VDR may be influenced by polymorphism in the VDR gene...
September 9, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28890615/antibacterial-inhibitory-effects-of-punica-granatum-gel-on-cariogenic-bacteria-an-in-vitro-study
#12
Grazielle Millo, Apa Juntavee, Ariya Ratanathongkam, Natsajee Nualkaew, Jomjai Peerapattana, Supaporn Chatchiwiwattana
AIM: This study evaluated the in vitro antibacterial effects of the formulated Punica granatum (PG) gel against Streptococcus mutans, Streptococcus sanguinis, and Lactobacillus casei. MATERIALS AND METHODS: The PG extract was dissolved in water at 500 mg/mL. High performance liquid chromatography (HPLC) was used for identification and quantification of chemical marker punicalagin. Minimum bactericidal concentration (MBC) and time-kill assay (TKA) were investigated...
April 2017: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28882767/optimization-of-alginate-microcapsules-containing-cells-overexpressing-%C3%AE-l-iduronidase-using-box-behnken-design
#13
Dirnete Diel, Valeska Lizzi Lagranha, Roselena Silvestri Schuh, Fernanda Bruxel, Ursula Matte, Helder Ferreira Teixeira
Mucopolysaccharidosis type I (MPS I) is an autosomal recessive disease caused by deficiency of α-l-iduronidase (IDUA), which results in the lysosomal accumulation of glycosaminoglycans (GAG) leading to widespread clinical manifestations. The microencapsulation of IDUA overexpressing recombinant cells has been considered as a promising strategy for the treatment of MPS I. This study aimed at the optimization of alginate microcapsules containing recombinant BHK (Baby Hamster Kidney) cells (rBHK) overexpressing IDUA produced by electrostatic extrusion technique...
September 4, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28879435/anti-herpes-simplex-virus-1-and-immunomodulatory-activities-of-a-poly-%C3%AE-glutamic-acid-from-bacillus-horneckiae-strain-apa-of-shallow-vent-origin
#14
Francesca Marino-Merlo, Emanuela Papaianni, Teresa L Maugeri, Vincenzo Zammuto, Antonio Spanò, Barbara Nicolaus, Annarita Poli, Paola Di Donato, Claudia Mosca, Antonio Mastino, Concetta Gugliandolo
Herpes simplex virus type 1 (HSV-1) is responsible of common and widespread viral infections in humans through the world, and of rare, but extremely severe, clinical syndromes in the central nervous system. The emergence of resistant strains to drugs actually in use encourages the searching for novel antiviral compounds, including those of natural origin. In this study, the recently described poly-γ-glutamic acid (γ-PGA-APA), produced by the marine thermotolerant Bacillus horneckiae strain APA, and previously shown to possess biological and antiviral activity, was evaluated for its anti-HSV-1 and immunomodulatory properties...
September 7, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28878718/errors-in-the-2017-apa-clinical-practice-guideline-for-the-treatment-of-ptsd-what-the-data-actually-says
#15
REVIEW
Sarah K Dominguez, Christopher W Lee
The American Psychological Association (APA) Practice Guidelines for the Treatment of Posttraumatic Stress Disorder (PTSD) concluded that there was strong evidence for cognitive behavioral therapy (CBT), cognitive processing therapy (CPT), cognitive therapy (CT), and exposure therapy yet weak evidence for eye movement desensitization and reprocessing (EMDR). This is despite the findings from an associated systematic review which concluded that EMDR leads to loss of PTSD diagnosis and symptom reduction. Depression symptoms were also found to improve more with EMDR than control conditions...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28877217/involvement-of-arginine-878-together-with-ca2-in-mouse-aminopeptidase-a-substrate-specificity-for-n-terminal-acidic-amino-acid-residues
#16
Pierre Couvineau, Hugo de Almeida, Bernard Maigret, Catherine Llorens-Cortes, Xavier Iturrioz
Aminopeptidase A (APA) is a membrane-bound zinc metalloprotease cleaving, in the brain, the N-terminal aspartyl residue of angiotensin II to generate angiotensin III, which exerts a tonic stimulatory effect on the control of blood pressure in hypertensive animals. Using a refined APA structure derived from the human APA crystal structure, we docked the specific and selective APA inhibitor, EC33 in the presence of Ca2+. We report the presence in the S1 subsite of Arg-887 (Arg-878 in mouse APA), the guanidinium moiety of which established an interaction with the electronegative sulfonate group of EC33...
2017: PloS One
https://www.readbyqxmd.com/read/28876380/portuguese-and-brazilian-guidelines-for-the-treatment-of-depression-exercise-as-medicine
#17
Lara F Carneiro, Maria P Mota, Felipe Schuch, Andrea Deslandes, José Vasconcelos-Raposo
Depression is a psychiatric disorder and major contributor to the burden of disease worldwide. The strength of evidence of the benefits of exercise as a therapeutic intervention for patients with depression has expanded in the last 30 years. In fact, the available evidence indicates exercise can not only help manage depressive symptoms, but also effect significant improvements in other health outcomes. Clinical guidelines including such recommendations have been issued by different agencies, namely the UK National Institute for Health and Clinical Excellence (NICE), the American Psychiatric Association (APA), and the Royal Australian and New Zealand College of Psychiatrists (RANZCP)...
August 30, 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/28876177/ancient-indian-concepts-about-phenomenology-biology-and-therapeutics-of-epilepsy
#18
Ravindra Arya
This article discusses etiology, pathogenesis, symptoms, and treatment of epilepsy, as described in Charaka Samhitā (translation: Charaka's Compendium) and Sushruta Samhitā, the two core texts of Ayurveda, an ancient system of medicine. Ayurveda emphasized amnesia and loss of consciousness as core features of epileptic seizures (Sanskrit: apasmar; translation: apa negation, smaran memory) and recognized that seizures occur due to a disturbance in brain function or flow of "humors" to the brain. Semiology of various seizure types was well described...
September 6, 2017: Journal of the History of the Neurosciences
https://www.readbyqxmd.com/read/28874086/pacluster-clustering-polyadenylation-site-data-using-canonical-correlation-analysis
#19
Guoli Ji, Qianmin Lin, Yuqi Long, Congting Ye, Wenbin Ye, Xiaohui Wu
Alternative polyadenylation (APA) is a pervasive mechanism that contributes to gene regulation. Increasing sequenced poly(A) sites are placing new demands for the development of computational methods to investigate APA regulation. Cluster analysis is important to identify groups of co-expressed genes. However, clustering of poly(A) sites has not been extensively studied in APA, where most APA studies failed to consider the distribution, abundance, and variation of APA sites in each gene. Here we constructed a two-layer model based on canonical correlation analysis (CCA) to explore the underlying biological mechanisms in APA regulation...
August 16, 2017: Journal of Bioinformatics and Computational Biology
https://www.readbyqxmd.com/read/28870781/aberrant-g-protein-receptor-expression-is-associated-with-dna-methylation-in-aldosterone-producing-adenoma
#20
Kiyotaka Itcho, Kenji Oki, Kazuhiro Kobuke, Yoko Yoshii, Haruya Ohno, Masayasu Yoneda, Noboru Hattori
This study aimed to evaluate the methylation levels of G protein-coupled receptor (GPCR) related genes and the effects of methylation on mRNA expression levels in aldosterone-producing adenoma (APA). DNA methylation array and transcriptome analysis were applied in non-functioning adrenocortical adenoma (NFA) and APA. We investigated 192 GPCR-related genes and found hypo-methylation in the promoter region of 66 of these genes in APA. An integration study between microarray and methylation analysis revealed that HTR4, MC2R, TACR1, GRM3, and PTGER1 showed hypo-methylation and up-regulation of mRNA in APA...
September 6, 2017: Molecular and Cellular Endocrinology
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