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https://www.readbyqxmd.com/read/28324984/prediction-method-for-intronic-alternative-polyadenylation-sites
#1
Shanxin Zhang
Alternative Polyadenylation (APA) of mRNAs has been proven as a considerable mechanism for post-transcriptional gene regulation. The interplay between Intronic APA and splicing may affect the isoforms of mRNAs. In this paper, we have found four prevalent motifs, i.e. AATAAA, TTTTTTTT, CCAGSCTGG and RGYRYRGTGG surrounding the polyadenylation sites; then we proposed a new computational method to identify the Intronic APA sites in the human genome, which is based on a Support Vector Machine (SVM) with weighted degree string kernel...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28301502/long-term-moderate-wind-induced-sediment-resuspension-meeting-phosphorus-demand-of-phytoplankton-in-the-large-shallow-eutrophic-lake-taihu
#2
Jian-Ying Chao, Yi-Min Zhang, Ming Kong, Wei Zhuang, Long-Mian Wang, Ke-Qiang Shao, Guang Gao
The objective of this study was to investigate the impact of sediment resuspension and phosphorus (P) release on phytoplankton growth under different kinds of wind-wave disturbance conditions in the large and shallow eutrophic Lake Taihu in China. Short-term strong wind (STSW) conditions, long-term moderate wind (LTMW) conditions, and static/calm conditions were investigated. To address this objective, we (1) monitored changes in surface water P composition during field-based sediment resuspension caused by STSW conditions in Lake Taihu, and also conducted (2) a series of laboratory-based sediment resuspension experiments to simulate LTMW and calm conditions...
2017: PloS One
https://www.readbyqxmd.com/read/28294236/ultrasensitive-electrochemical-detection-of-dicer1-3-utr-for-the-fast-analysis-of-alternative-cleavage-and-polyadenylation
#3
Hui Zhao, Feng Liu, Shilian Wu, Long Yang, Ya-Ping Zhang, Can-Peng Li
Alternative cleavage and polyadenylation (APA) is involved in several important biological processes in animals, e.g. cell growth and development, and cancer progression. The increasing data show that cancer cells are inclined to produce mRNA isoforms with a shortened 3'UTR undergoing APA. For example, the Dicer1 isoform with a shorter 3'untranslated region (3'UTR) was found to be overexpressed in some cancer cells, which may be used as a potential novel prognostic biomarker for cancer. In the present work, a novel electrochemical biosensor for ultrasensitive determination of Dicer1 was designed by using gold nanoparticles and p-sulfonated calix[6]arene functionalized reduced graphene oxide (Au@SCX6-rGO) as nanocarriers...
March 15, 2017: Nanoscale
https://www.readbyqxmd.com/read/28286578/validity-of-the-microsoft-kinect-system-in-assessment-of-compensatory-stepping-behavior-during-standing-and-treadmill-walking
#4
Guy Shani, Amir Shapiro, Goldstein Oded, Kagan Dima, Itshak Melzer
BACKGROUND: Rapid compensatory stepping plays an important role in preventing falls when balance is lost; however, these responses cannot be accurately quantified in the clinic. The Microsoft Kinect™ system provides real-time anatomical landmark position data in three dimensions (3D), which may bridge this gap. METHODS: Compensatory stepping reactions were evoked in 8 young adults by a sudden platform horizontal motion on which the subject stood or walked on a treadmill...
2017: European Review of Aging and Physical Activity
https://www.readbyqxmd.com/read/28284667/center-of-pressure-and-center-of-mass-behavior-during-gait-initiation-on-inclined-surfaces-a-statistical-parametric-mapping-analysis
#5
Marcus Fraga Vieira, Ademir Alves de Brito, Georgia Cristina Lehnen, Fábio Barbosa Rodrigues
This study analyzed gait initiation (GI) on inclined surfaces with 68 young adult subjects of both sexes. Ground reaction forces and moments were collected using two AMTI force platforms, of which one was in a horizontal position and the other was inclined by 8% in relation to the horizontal plane. Departing from a standing position, each participant executed three trials in the following conditions: horizontal position (HOR), inclined position at ankle dorsi-flexion (UP), and inclined position at ankle plantar-flexion (DOWN)...
February 27, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28275124/a-modelling-approach-to-the-dynamics-of-gait-initiation
#6
Manish Anand, Justin Seipel, Shirley Rietdyk
Gait initiation is an integral and complex part of human locomotion. In this paper, we present a novel compliant-leg model-based approach to understanding the key phases of initiation, the nature of the effective forces involved in initiation, and the importance of the anticipatory postural adjustments (APAs). The results demonstrate that in the presence of APAs, we observe a change in the characteristic of forcing required for initiation, and the energetic cost of gait initiation is also reduced by approximately 58%...
March 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/28274321/-preparation-of-monoclonal-antibody-against-4-amylphenol-and-homology-modeling-of-its-fv-fragment
#7
Lei Cheng, Haizhen Wu, Jing Fei, Lujia Zhang, Jiang Ye, Huizhan Zhang
Objective To prepare and characterize a monoclonal antibody (mAb) against 4-amylphenol (4-AP), clone its cDNA sequence and make homology modeling for its Fv fragment. Methods A high-affinity anti-4-AP mAb was generated from a hybridoma cell line F10 using electrofusion between splenocytes from APA-BSA-immunized mouse and Sp2/0 myeloma cells. Then we extracted the mRNA of F10 cells and cloned the cDNA of mAb. The homology modeling and molecular docking of its Fv fragment was conducted with biological software...
March 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/28271221/control-of-vertical-posture-while-elevating-one-foot-to-avoid-a-real-or-virtual-obstacle
#8
Hirofumi Ida, Sambit Mohapatra, Alexander Aruin
The purpose of this study is to investigate the control of vertical posture during obstacle avoidance in a real versus a virtual reality (VR) environment. Ten healthy participants stood upright and lifted one leg to avoid colliding with a real obstacle sliding on the floor toward a participant and with its virtual image. Virtual obstacles were delivered by a head mounted display (HMD) or a 3D projector. The acceleration of the foot, center of pressure, and electrical activity of the leg and trunk muscles were measured and analyzed during the time intervals typical for early postural adjustments (EPAs), anticipatory postural adjustments (APAs), and compensatory postural adjustments (CPAs)...
March 7, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28261073/recovery-from-multiple-apas-delays-gait-initiation-in-parkinson-s-disease
#9
Rajal G Cohen, John G Nutt, Fay B Horak
Background: Freezing of gait in Parkinson's disease (PD) has been linked with deficits in inhibitory control, but causal mechanisms are not established. Freezing at gait initiation (start hesitation) is often accompanied by multiple anticipatory postural adjustments (APAs). If inhibition deficits contribute to freezing by interfering with ability to inhibit initial weight shifts in the wrong direction, then PD subjects should experience more episodes of multiple APAs than healthy controls (HCs) do. If inhibition deficits contribute to freezing by interfering with ability to release a previously inhibited step following multiple APAs, then step onset following multiple APAs should be delayed more in people with PD than in HCs...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28255306/implications-of-antiphospholipid-and-antineutrophilic-cytoplasmic-antibodies-in-the-context-of-postinfectious-glomerulonephritis
#10
Daniel Leifer, Lavjay Butani
While antineutrophil cytoplasmic antibody (ANCA) positivity has been documented in some patients with postinfectious glomerulonephritis (PIGN) and is associated with more severe disease, antiphospholipid antibodies (APA) are not known to be a common occurrence. We describe a child with severe acute kidney injury who was noted to have prolonged positivity of both ANCA and APA; a renal biopsy showed noncrescentic immune complex mediated glomerulonephritis with subepithelial deposits compatible with PIGN. He recovered without maintenance immunosuppressive therapy and at last follow-up had normal renal function...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/28254637/anticipatory-postural-adjustment-during-self-initiated-cued-and-compensatory-stepping-in-healthy-elderly-and-patients-with-parkinson-s-disease
#11
Christian Schlenstedt, Martina Mancini, Fay Horak, Daniel Peterson
OBJECTIVE: To characterize anticipatory postural adjustments (APA) across a variety of step initiation tasks in people with Parkinson's disease (PD) and healthy control (HC). DESIGN: Cross-sectional study. Step initiation was analyzed during a) self-initiated gait, b) perceptual cued gait, and c) compensatory forward stepping after platform perturbation. People with PD were assessed On and Off levodopa. SETTING: University research laboratory...
February 27, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28249410/parameter-independent-low-power-heteronuclear-decoupling-for-fast-magic-angle-spinning-solid-state-nmr
#12
Asif Equbal, P K Madhu, Beat H Meier, Niels Chr Nielsen, Matthias Ernst, Vipin Agarwal
Major advances have recently been made in the field of heteronuclear dipolar decoupling in solid-state nuclear magnetic resonance (NMR). These developments have improved the resolution and sensitivity of the NMR spectrum of spins coupled to protons. One such new scheme, denoted as rCW(ApA), has proven to be robust with practically no need for parameter optimization [A. Equbal et al. Chem. Phys. Lett., 635, 339 (2015)]. Most of the experiments with rCW(ApA) have been carried out in the regimes of slow to moderate magic-angle spinning while simultaneously applying high decoupling radio-frequency amplitudes...
February 28, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28249076/a-consensus-statement-on-the-use-of-ketamine-in-the-treatment-of-mood-disorders
#13
Gerard Sanacora, Mark A Frye, William McDonald, Sanjay J Mathew, Mason S Turner, Alan F Schatzberg, Paul Summergrad, Charles B Nemeroff
Importance: Several studies now provide evidence of ketamine hydrochloride's ability to produce rapid and robust antidepressant effects in patients with mood and anxiety disorders that were previously resistant to treatment. Despite the relatively small sample sizes, lack of longer-term data on efficacy, and limited data on safety provided by these studies, they have led to increased use of ketamine as an off-label treatment for mood and other psychiatric disorders. Observations: This review and consensus statement provides a general overview of the data on the use of ketamine for the treatment of mood disorders and highlights the limitations of the existing knowledge...
March 1, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28248752/radiofrequency-ablation-treatment-for-aldosterone-producing-adenomas
#14
Barry A Sacks, Ari C Sacks, Salomao Faintuch
PURPOSE OF REVIEW: To review the current status of radiofrequency ablation as a primary treatment for hyperfunctioning adrenal nodules, predominantly aldosterone-producing adenomas (APAs). RECENT FINDINGS: Radiofrequency ablation is an established treatment for focal benign and malignant lesions, including metastatic disease to the adrenal gland. Hyperaldosteronism is the leading cause of secondary hypertension with up to 80% due to APA, statistically the most common functioning adrenal nodule...
February 28, 2017: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/28245451/pituitary-autoimmunity
#15
Federica Guaraldi, Roberta Giordano, Silvia Grottoli, Lucia Ghizzoni, Emanuela Arvat, Ezio Ghigo
Pituitary autoimmunity, considered a synonym of autoimmune hypophysitis, defines a wide spectrum of conditions (neoplastic, functional, and iatrogenic pituitary disorders; and extra-pituitary autoimmune and non-autoimmune diseases), and is characterized by the presence of antipituitary antibodies (APAs) at various titer and prevalence. These conditions have been increasingly recognized not only in adults, but also in children. The autoimmune pathogenesis, histological features of the primary (i.e. lymphocytic, granulomatous, xanthomatous, IgG-4 related lymphoplasmacytic, and necrotizing) forms, and the pathognomonic association of lymphocytic hypophysitis with pregnancy and CTLA-4 antibody therapy, have been clearly demonstrated...
2017: Frontiers of Hormone Research
https://www.readbyqxmd.com/read/28241423/metabolic-profiling-as-a-screening-tool-for-cytotoxic-compounds-identification-of-3-alkyl-pyridine-alkaloids-from-sponges-collected-at-a-shallow-water-hydrothermal-vent-site-north-of-iceland
#16
Eydis Einarsdottir, Manuela Magnusdottir, Giuseppe Astarita, Matthias Köck, Helga M Ögmundsdottir, Margret Thorsteinsdottir, Hans Tore Rapp, Sesselja Omarsdottir, Giuseppe Paglia
Twenty-eight sponge specimens were collected at a shallow water hydrothermal vent site north of Iceland. Extracts were prepared and tested in vitro for cytotoxic activity, and eight of them were shown to be cytotoxic. A mass spectrometry (MS)-based metabolomics approach was used to determine the chemical composition of the extracts. This analysis highlighted clear differences in the metabolomes of three sponge specimens, and all of them were identified as Haliclona (Rhizoniera) rosea (Bowerbank, 1866). Therefore, these specimens were selected for further investigation...
February 22, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28225700/seeking-legitimacy-for-dsm-5-the-bereavement-exception-as-an-example-of-failed-process
#17
James E Sabin, Norman Daniels
In 2013 the American Psychiatric Association (APA) published the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). Even before publication, DSM-5 received a torrent of criticism, most prominently over removal of the "bereavement exclusion" for the diagnosis of major depression. We argue that while the APA can claim legitimate authority for deciding scientific questions, it does not have legitimacy for resolving what is ultimately a question of ethics and public policy. We show how the "accountability for reasonableness" framework for seeking legitimacy in health policy could have been used to achieve a better resolution of the conflict than actually occurred...
February 1, 2017: AMA Journal of Ethics
https://www.readbyqxmd.com/read/28224338/the-response-of-phosphorus-uptake-strategies-of-microcystis-aeruginosa-to-hydrodynamics-fluctuations
#18
Yue Zheng, Wujuan Mi, Yonghong Bi, Zhengyu Hu
The mechanisms of hydrodynamic fluctuation that affect cyanobacterial physiological aspects are still unclear. This study was conducted to screen the effects of hydrodynamic fluctuation on phosphorus (P) uptake by Microcystis aeruginosa. Four levels of circumfluence (0, 100, 200, and 300 rpm) and three concentrations of P (0.5, 2.0, and 5.0 mgL(-1)) were used, and the specific growth rate, cell viability, P uptake kinetic, and alkaline phosphatase activity (APA) were determined. Results showed that M. aeruginosa had a higher specific growth rate, cell viability, and P uptake rate at low and moderate circumfluence, APA increased with a decrease of the cellular P quota (Qp)...
February 21, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28221077/stanley-stan-kuczaj-ii-1950-2016
#19
Jennifer Vonk
Presents an obituary for Stanley (Stan) Kuczaj II who passed away suddenly on April 14, 2016 at the age of 65 in his home in Hattiesburg Mississippi. The field of comparative cognition and animal behavior lost a leader, a friend, and a mentor that day. At the time of his passing, Stan was a fellow and the president of the Society for Comparative Psychology and Behavioral Neuroscience, Division 6, of the American Psychological Association (APA). He was also a fellow of the American Association for the Advancement of Science, APA's Divisions 3 and 7, and the Psychonomic Society...
February 2017: American Psychologist
https://www.readbyqxmd.com/read/28221076/lorraine-williams-greene-1950-2016
#20
Guy Seymour, Adrienne Bradford
Presents an obituary for Lorraine Williams Greene who died on February 25, 2016. Lorraine started her professional career as a school psychologist for the Atlanta Public Schools. For the rest of her life, she was involved in her community through her church, her sorority, the Coalition of One Hundred Black Women, and other national and local service organizations. Within the American Psychological Association (APA), Lorraine was active in Division 18, Psychologists in Public Service, first as Chair of the Police and Public Safety Section, then as the division's representative to APA Council, and, in 2016, as President-elect of the Division...
February 2017: American Psychologist
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