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https://www.readbyqxmd.com/read/28102204/the-prevalence-of-ctnnb1-mutations-in-primary-aldosteronism-and-consequences-for-clinical-outcomes
#1
Vin-Cent Wu, Shuo-Meng Wang, Shih-Chieh Jeff Chueh, Shao-Yu Yang, Kuo-How Huang, Yen-Hung Lin, Jian-Jhong Wang, Rory Connolly, Ya-Hui Hu, Celso E Gomez-Sanchez, Kang-Yung Peng, Kwan-Dun Wu
Constitutive activation of the Wnt pathway/β-catenin signaling may be important in aldosterone-producing adenoma (APA). However, significant gaps remain in our understanding of the prevalence and clinical outcomes after adrenalectomy in APA patients harboring CTNNB1 mutations. The molecular expression of CYP11B2 and gonadal receptors in adenomas were also explored. Adenomas from 219 APA patients (95 men; 44.2%; aged 50.5 ± 11.9 years) showed a high rate of somatic mutations (n = 128, 58.4%). The majority of them harbored KCNJ5 mutations (n = 116, 52...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28088660/processes-of-anticipatory-postural-adjustment-and-step-movement-of-gait-initiation
#2
Hiroki Mizusawa, Yasutomo Jono, Yasuyuki Iwata, Atsushi Kinoshita, Koichi Hiraoka
The purpose of this study was to elucidate whether the anticipatory postural adjustment (APA) and focal step movement of gait initiation are produced as a single process or different processes and whether the APA receives an inhibitory drive from the ongoing stop process of gait initiation. Healthy humans initiated gait in response to a first visual cue that instructed the initial swing leg. In some trials, a switch or stop cue was also provided after the first cue. When the stop cue was provided, participants withheld gait initiation...
January 12, 2017: Human Movement Science
https://www.readbyqxmd.com/read/28081000/on-the-development-of-a-vipar-nd-radiotherapy-3d-polymer-gel-dosimeter
#3
Marek Kozicki, Malwina Jaszczak, Piotr Maras, Mariusz Dudek, Marian Cłapa
This work presents an improvement of the VIPAR(nd) ('nd' stands for 'normoxic, double', or VIP) polymer gel dosimeter. The gel composition was altered by increasing the concentration of the monomeric components, N-vinylpyrrolidone (NVP) and N,N'-methylenebisacrylamide (MBA), in co-solvent solutions. The optimal composition (VIPAR(CT), where 'CT' stands for computed tomography, or VIC) comprised: 17% NVP, 8% MBA, 12% t-BuOH, 7.5% gelatine, 0.007% ascorbic acid, 0.0008% CuSO4  ×  5H2O and 0.02% hydroquinone...
February 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28080103/empirical-influence-of-the-multicultural-guidelines-a-brief-report
#4
Nadya A Fouad, Mercedes Santana, Arpita Ghosh
OBJECTIVE: In 2002, the American Psychological Association (APA) Council of Representatives approved the "Guidelines for Multicultural Education, Training, Research, Practice and Organizational Change for Psychologists." The Guidelines have been downloaded 64,153 times from the APA website from 2007 to 2013, and have been cited nearly 900 times. This suggests that the Guidelines have influenced education, training, research, and practice in psychology. However, it is unclear how the Guidelines have influenced these domains...
January 12, 2017: Cultural Diversity & Ethnic Minority Psychology
https://www.readbyqxmd.com/read/28069385/changes-of-renin-angiotensin-system-related-aminopeptidases-in-early-stage-alzheimer-s-disease
#5
Paul Richard Gard, Sara Fidalgo, Isabelle Lotter, Cassandra Richardson, Nicolas Farina, Jennifer Rusted, Naji Tabet
Activities of aminopeptidases A, B, and N (ApA, ApB & ApN) and insulin-regulated aminopeptidase (IRAP) have been seen to be decreased amongst patients with Alzheimer's disease (AD). All of these enzymes are involved with the brain renin-angiotensin system which is believed to be involved with learning and memory. This study aimed to explore the time course and the mechanisms underlying these changes. Serum samples were collected from 45 AD patients at the start of the study, and again 13months later (n=37)...
January 7, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28066693/society-of-pediatric-psychology-workforce-survey-development-of-survey-methods-sample-characteristics-and-lessons-learned
#6
Tim Wysocki, Cheryl L Brosig, Marisa E Hilliard
There are few detailed workforce studies of specialty fields within professional psychology, and none have been reported for pediatric psychology since 2006. Availability of such data could facilitate more-informed decision making by students and trainees, psychologists pursuing employment opportunities, and psychologists involved in employment or compensation negotiations. This article describes the work of a task force of the American Psychological Association (APA) Division 54 (Society of Pediatric Psychology) in the design, construction, pretesting, distribution, and data management for the Society of Pediatric Psychology (SPP) Workforce Survey...
March 2016: Clinical Practice in Pediatric Psychology
https://www.readbyqxmd.com/read/28063294/the-effect-of-coagulants-and-antiscalants-discharged-with-seawater-desalination-brines-on-coastal-microbial-communities-a-laboratory-and-in-situ-study-from-the-southeastern-mediterranean
#7
Natalia Belkin, Eyal Rahav, Hila Elifantz, Nurit Kress, Ilana Berman-Frank
Desalination outflows frequently discharge brine containing coagulants and antiscalants (e.g. Iron-hydroxides and polyphosphonates) to the coastal environment. Here we examined changes in composition and productivity of natural microbial coastal communities in experimental mesocosms treated with either iron-hydroxide (Fe), polyphosphonate (Pn), or a combination of high salinities with both chemicals (All). Within 2 h of addition Fe already altered the microbial community composition, enhanced the bacterial production (BP) and cell specific production (BP/BA), and decreased primary production...
December 10, 2016: Water Research
https://www.readbyqxmd.com/read/28032799/gloria-behar-gottsegen-1930-2015
#8
Florence L Denmark
Presents an obituary for Gloria Behar Gottsegen, who died on April 21, 2015, in Boca Raton, Florida. Trained as a school psychologist, she was also a teacher, consultant, and author. But she is probably best known for her long and active history with the American Psychological Association (APA), during which she held dozens of positions, including the presidency of four divisions. (PsycINFO Database Record
December 2016: American Psychologist
https://www.readbyqxmd.com/read/28032786/revision-of-ethical-standard-3-04-of-the-ethical-principles-of-psychologists-and-code-of-conduct-2002-as-amended-2010
#9
(no author information available yet)
The following amendment to Ethical Standard 3.04 of the 2002 "Ethical Principles of Psychologists and Code of Conduct" as amended, 2010 (the Ethics Code; American Psychological Association, 2002, 2010) was adopted by the APA Council of Representatives at its August 2016 meeting. The amendment will become effective January 1, 2017. Following is an explanation of the change, a clean version of the revision, and a version indicating changes from the 2002 language (inserted text is in italics). (PsycINFO Database Record...
December 2016: American Psychologist
https://www.readbyqxmd.com/read/28018191/hebb-and-cattell-the-genesis-of-the-theory-of-fluid-and-crystallized-intelligence
#10
REVIEW
Richard E Brown
Raymond B. Cattell is credited with the development of the theory of fluid and crystallized intelligence. The genesis of this theory is, however, vague. Cattell, in different papers, stated that it was developed in 1940, 1941 or 1942. Carroll (1984, Multivariate Behavioral Research, 19, 300-306) noted the similarity of Cattell's theory to "Hebb's notion of two types of intelligence," which was presented at the 1941 APA meeting, but the matter has been left at that. Correspondence between Cattell, Donald Hebb and George Humphrey of Queen's University, Kingston, Ontario, however, indicates that Cattell adopted Hebb's ideas of intelligence A and B and renamed them...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28013421/measuring-core-temperature-using-the-proprietary-application-and-thermo-smartphone-adapter
#11
Tomasz Darocha, Jacek Majkowski, Tomasz Sanak, Paweł Podsiadło, Sylweriusz Kosiński, Kinga Sałapa, Piotr Mazur, Mirosław Ziętkiewicz, Robert Gałązkowski, Łukasz Krzych, Rafał Drwiła
Fast and accurate measurement of core body temperature is crucial for accidental hypothermia treatment. We have developed a novel light and small adapter to the headset jack of a mobile phone based on Android. It has been applied to measure temperature and set up automatic notifications (e.g. Global Positioning System coordinates to emergency services dispatcher, ECMO coordinator). Its validity was confirmed in comparison with Vital Signs Monitor Spacelabs Healthcare Elance 93300 as a reference method, in a series of 260 measurements in the temperature range of 10-42 °C...
December 24, 2016: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/28004203/aging-effect-on-muscle-synergies-in-stepping-forth-during-a-forward-perturbation
#12
Yun Wang, Kazuhiko Watanabe, Tadayoshi Asaka
PURPOSE: We explored changes in muscle interactions during healthy aging as a window into neural control strategies of postural preparation to action/perturbation. In particular, we quantified the strength of multi-muscle synergies stabilizing the center of pressure (COP) displacement during the preparation for making a step associated with support surface translations. METHODS: Young and elderly subjects were required to make a step in response to support surface perturbations...
December 21, 2016: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/27995747/new-3-alkylpyridine-marine-alkaloid-analogues-as-promising-antitumor-agents-against-the-cd44-high-cd24-low-subset-of-triple-negative-breast-cancer-tnbc-cell-line
#13
Aline Brito de Lima, Camila de Souza Barbosa, Alessandra Mirtes Marques Neves Gonçalves, Fabio Vieira Dos Santos, Gustavo Henrique Ribeiro Viana, Fernando de Pilla Varotti, Luciana Maria Silva
Triple-negative breast cancer (TNBC) is one of the most aggressive cancers in women. Additionally, presence of residual cancer-stem-cells (CSC) in TNBC has challenged the efficacy of chemotherapy. Thus, the development of new molecules with potential action against CSC is fundamental. In this study, six synthetic analogues of Theonelladin C, a 3-alkylpyridine marine alkaloid (3-APA), were tested for cytotoxic activity against human TNBC cell line (BT-549) and tumorspheres derived from BT-549. Cytotoxicity assay was performed by sulforhodamine B (SRB)...
December 19, 2016: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/27990575/dynamic-landscape-of-alternative-polyadenylation-during-retinal-development
#14
Wenyan Hu, Shengguo Li, Ji Yeon Park, Sridhar Boppana, Ting Ni, Miaoxin Li, Jun Zhu, Bin Tian, Zhi Xie, Mengqing Xiang
The development of the central nervous system (CNS) is a complex process that must be exquisitely controlled at multiple levels to ensure the production of appropriate types and quantity of neurons. RNA alternative polyadenylation (APA) contributes to transcriptome diversity and gene regulation, and has recently been shown to be widespread in the CNS. However, the previous studies have been primarily focused on the tissue specificity of APA and developmental APA change of whole model organisms; a systematic survey of APA usage is lacking during CNS development...
December 18, 2016: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/27987305/a-descriptive-study-of-effect-size-reporting-in-research-reviews
#15
Judith A Floyd
AIM: To describe effect-size reporting in research reviews completed in support of evidence-based practice in nursing. BACKGROUND: Many research reviews report nurses' critical appraisal of level, quality and overall strength of evidence available to address clinical questions. Several studies of research-review quality suggest effect-size information would be useful to include in these reviews, but none focused on reviewers' attention to effect sizes. DESIGN: Descriptive...
December 17, 2016: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/27983555/the-effects-of-meditation-on-grey-matter-atrophy-and-neurodegeneration-a%C3%A2-systematic-review
#16
Nicole Last, Emily Tufts, Leslie E Auger
The present systematic review is based on the premise that a variety of neurodegenerative diseases are accompanied by grey matter atrophy in the brain and meditation may impact this. Given that age is a major risk factor for many of these progressive and neurodegenerative diseases and that the percentage of the population over the age of 65 is quickly increasing, there is an obvious need for prompt treatment and prevention advances in research. As there is currently no cure for Alzheimer's disease and other neurodegenerative diseases, many are seeking non-pharmacological treatment options in attempts to offset the disease-related cognitive and functional declines...
November 26, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27981895/alternative-polyadenylation-in-a-family-of-paralogous-epb41-genes-generates-protein-4-1-diversity
#17
Laura Rangel, Eva Lospitao, Ana Ruiz-Sáenz, Miguel A Alonso, Isabel Correas
Alternative polyadenylation (APA) is a step in mRNA 3'-end processing that contributes to the complexity of the transcriptome by generating isoforms that differ in either their coding sequence or their 3'-untranslated regions (UTRs). The EPB41 genes, EPB41, EPB41L2, EPB41L3 and EPB41L1, encode an impressively complex array of structural adaptor proteins (designated 4.1R, 4.1G, 4.1B and 4.1N, respectively) by using alternative transcriptional promoters and tissue-specific alternative pre-mRNA splicing. The great variety of 4...
December 16, 2016: RNA Biology
https://www.readbyqxmd.com/read/27977278/international-humanitarian-award
#18
(no author information available yet)
The International Humanitarian Award recognizes extraordinary humanitarian services and activism by psychologists, including professional and volunteer work conducted primarily in the field with underserved populations. Award recipients are psychologists who, by their extraordinary service at a difficult time, improve the lives and contribute to the well-being of people in a large or small geographic area anywhere in the world. The 2016 recipient of the APA International Humanitarian Award was selected by the 2015 Committee on International Relations in Psychology (CIRP)...
November 2016: American Psychologist
https://www.readbyqxmd.com/read/27977275/award-for-distinguished-contributions-to-the-international-advancement-of-psychology
#19
(no author information available yet)
This award is given to individuals who have made sustained and enduring contributions to international cooperation and the advancement of knowledge in psychology. The 2016 recipient of the APA Award for Distinguished Contributions to the International Advancement of Psychology was selected by the 2015 Committee on International Relations in Psychology (CIRP). The members of the 2015 CIRP were Rehman Abdulrehman, PhD (Chair); Gonzalo Bacigalupe, EdD; Silvia S. Canetto, PhD; Amanda Clinton, PhD; Melissa L. Morgan Consoli, PhD; Chryse G...
November 2016: American Psychologist
https://www.readbyqxmd.com/read/27977274/apa-apags-award-for-distinguished-graduate-student-in-professional-psychology-luz-maria-garcini
#20
(no author information available yet)
The APA/APAGS Award for Distinguished Graduate Student in Professional Psychology is awarded on an annual basis by the APA Board of Professional Affairs (BPA) and the American Psychological Association of Graduate Students (APAGS) to a graduate student who has demonstrated outstanding practice and application of psychology. The 2016 award winners is Luz Maria Garcini, whose commitment to the health and mental health of those recently immigrated has led to research and service that "have greatly benefited the lives of undocumented individuals in the border area of southern California...
November 2016: American Psychologist
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