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https://www.readbyqxmd.com/read/29790291/the-eyes-have-it-a-rheumatologist-s-view-of-uveitis
#1
REVIEW
James T Rosenbaum, Andrew D Dick
Uveitis is defined as intraocular inflammation. It is an extra-articular manifestation of many forms of joint disease which include spondyloarthritis, juvenile idiopathic arthritis, and Behcet's disease. Rheumatologists may be asked to consult on patients with uveitis in order to identify an associated systemic illness. Diagnoses such as spndyloarthritis, sarcoidosis, and interstitial nephritis with uveitis are frequently overlooked by referring ophthalmologists. Alternatively rheumatologists may be asked to help manage the immunosuppression including biologics which can be required to treat a subset of patients with uveitis...
May 23, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29788871/biologics-for-the-treatment-of-juvenile-idiopathic-arthritis
#2
Dimitri Poddighe, Micol Romano, Maurizio Gattinara, Valeria Gerloni
Juvenile Idiopathic Arthritis (JIA) is one of the most common chronic diseases in children. Recently, the management of JIA has substantially changed, thanks to the availability of new treatment options, represented by biological drugs or biologics. These drugs modulate specific mechanisms of the immune systems, such as TNF-α, IL-1 and IL-6 signaling, or lymphocyte activation and/or functioning. In this review, we provide a comprehensive discussion on the current recommendations and clinical evidences regarding the use of the available biologics in the treatment of JIA; moreover, the main pharmacokinetic and pharmacodynamic aspects of any specific biologic drug have been summarized...
May 21, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29786780/correction-to-the-italian-version-of-the-juvenile-arthritis-multidimensional-assessment-report-jamar
#3
Alessandro Consolaro, Francesca Bovis, Angela Pistorio, Rolando Cimaz, Fabrizio De Benedetti, Angela Miniaci, Fabrizia Corona, Valeria Gerloni, Silvana Martino, Serena Pastore, Patrizia Barone, Sara Pieropan, Elisabetta Cortis, Rosa Anna Podda, Romina Gallizzi, Adele Civino, Francesco La Torre, Donato Rigante, Rita Consolini, Maria Cristina Maggio, Silvia Magni-Manzoni, Francesca Perfetti, Giovanni Filocamo, Claudia Toppino, Francesco Licciardi, Marco Garrone, Silvia Scala, Elisa Patrone, Monica Tonelli, Daniela Tani, Angelo Ravelli, Alberto Martini, Nicolino Ruperto
The family name of author Francesco La Torre was incorrect in the published article. The correct family name should read as La Torre F.
May 21, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29781829/comparison-of-adults-with-polyarticular-juvenile-idiopathic-arthritis-to-adults-with-rheumatoid-arthritis-a-cross-sectional-analysis-of-clinical-features-and-medication-use
#4
Danielle M Feger, Nicholas Longson, Hiranda Dodanwala, Barbara E Ostrov, Nancy J Olsen, Rayford R June
BACKGROUND/OBJECTIVE: Many individuals with juvenile idiopathic arthritis (JIA) have persistent disease into adulthood. Polyarticular JIA (pJIA) is often mislabeled as rheumatoid arthritis (RA) in adult rheumatology clinics, and treatment for adult pJIA patients is not well defined. We aimed to describe clinical features and medication use in the adult pJIA population in relation to an RA control cohort. METHODS: We performed a cross-sectional study of 45 adults with pJIA and 94 with RA seen from 2013 to 2017...
May 17, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29773851/modeling-transcriptional-rewiring-in-neutrophils-through-the-course-of-treated-juvenile-idiopathic-arthritis
#5
Zihua Hu, Kaiyu Jiang, Mark Barton Frank, Yanmin Chen, James N Jarvis
Neutrophils in children with the polyarticular form of juvenile idiopathic arthritis (JIA) display abnormal transcriptional patterns linked to fundamental metabolic derangements. In this study, we sought to determine the effects of therapy on mRNA and miRNA expression networks in polyarticular JIA. Using exon and miRNA microarrays, we studied children with untreated active JIA (ADU, n = 35), children with active disease on therapy with methotrexate ± etanercept (ADT, n = 26), and children with inactive disease also on therapy (ID, n = 14)...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29773271/juvenile-idiopathic-arthritis-associated-uveitis
#6
REVIEW
Ethan S Sen, A V Ramanan
Juvenile idiopathic arthritis (JIA) is the commonest rheumatic disease in children and JIA-associated uveitis its most frequent extra-articular manifestation. The uveitis is potentially sight-threatening and thus carries a considerable risk of morbidity with associated reduction in quality of life. The commonest form of uveitis seen in association with JIA is chronic anterior uveitis, which is almost always asymptomatic in the initial stages. Therefore, screening for JIA-associated uveitis in at-risk patients is essential...
August 2017: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/29773270/systemic-juvenile-idiopathic-arthritis-new-insights-into-pathogenesis-and-cytokine-directed-therapies
#7
REVIEW
Manuela Pardeo, Claudia Bracaglia, Fabrizio De Benedetti
Systemic juvenile idiopathic arthritis (sJIA) is considered as a polygenic autoinflammatory disease. The prominent systemic clinical features, the marked elevation of inflammatory markers, and the absence of autoantibodies make this disease very different from the other juvenile idiopathic arthritis (JIA) forms. Innate immune mechanisms appear to play a central role: the overproduction of inflammatory cytokines of innate immunity is a typical feature of sJIA. Increased understanding of the role of these cytokines has been translated into therapeutic approaches...
August 2017: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/29773268/recent-therapeutic-advances-in-juvenile-idiopathic-arthritis
#8
REVIEW
Gabriella Giancane, Alessandra Alongi, Silvia Rosina, Jessica Tibaldi, Alessandro Consolaro, Angelo Ravelli
Over the past two decades, the management of juvenile idiopathic arthritis (JIA) has been revolutionized by the increased tendency toward early aggressive interventions and the availability of the novel biologic medications. In 2017, three novel randomized controlled trials have evaluated the effectiveness and tolerability of golimumab and tocilizumab in polyarticular JIA, and shown that methotrexate may increase and prolong the effect of intra-articular corticosteroid injection in children with oligoarthritis...
August 2017: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/29773267/update-on-research-and-clinical-translation-on-specific-clinical-areas-from-biology-to-bedside-unpacking-the-mysteries-of-juvenile-idiopathic-arthritis-pathogenesis
#9
REVIEW
Jorg van Loosdregt, Femke van Wijk, Berent Prakken, Bas Vastert
In the past decades, we have gained important insights into the mechanisms of disease and therapy underlying chronic inflammation in juvenile idiopathic arthritis (JIA). These insights have resulted in several game-changing therapeutic modalities for many patients. However, additional progress still has to be made with regard to efficacy, cost reduction, minimization of side effects, and dose-tapering and stop strategies of maintenance drugs. Moreover, to really transform the current therapeutic strategies into personalized medicine, we need validated biomarkers to translate increased insights into clinical practice...
August 2017: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/29771573/increased-circulating-proinflammatory-t-lymphocytes-in-children-with-different-forms-of-anterior-uveitis-results-from-a-pilot-study
#10
Karoline Walscheid, Lisa Neekamp, Arnd Heiligenhaus, Toni Weinhage, Carsten Heinz, Dirk Foell
PURPOSE: To characterize peripheral blood T cells in juvenile idiopathic arthritis-associated uveitis (JIAU). METHODS: Blood samples were taken from children with JIAU (n = 18), JIA without ocular involvement (n = 11), idiopathic anterior uveitis (IAU, n = 12), and healthy controls (n = 11). Cells were stained for T cell surface markers, and intracellular cytokine staining was performed after cell stimulation and analyzed by flow cytometry. RESULTS: The Th1/Th2 ratio was increased in JIAU patients...
May 17, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29769136/vitamin-d-and-juvenile-idiopathic-arthritis
#11
REVIEW
Sarah L Finch, Alan M Rosenberg, Hassan Vatanparast
BACKGROUND: Vitamin D has been implicated in the pathogenesis of autoimmune diseases. While the roles of vitamin D in other autoimmune diseases have been investigated, less is known about the role of vitamin D in chronic childhood arthritis. MAIN BODY: This review summarizes and evaluates evidence relating to 25-hydroxyvitamin D (25(OH)D) and chronic childhood arthritis. A scoping literature review was conducted using Ovid Medline, Ovid Embase, Cumulative Index to Nursing and Allied Health Literature, Web of Science and Scopus...
May 16, 2018: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/29766264/-registry-based-research-in-ophthalmology
#12
REVIEW
J Li, C Heinz, R P Finger
Medical registries and registry studies are frequently used for health services research as they represent a valuable means of capturing real-life data. Registry studies are particularly suitable for rare diseases for which epidemiological population-based or randomized controlled clinical studies are difficult. The are many examples of successful medical registries that have not only contributed to both epidemiological and clinical research, but which have also improved health service delivery. Only few ophthalmological medical registries are currently available...
May 15, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29766253/update-on-imaging-in-juvenile-idiopathic-arthritis
#13
REVIEW
Karen Rosendahl, Mario Maas
No abstract text is available yet for this article.
June 2018: Pediatric Radiology
https://www.readbyqxmd.com/read/29766251/imaging-of-the-hip-in-juvenile-idiopathic-arthritis
#14
REVIEW
Susan Cheng Shelmerdine, Pier Luigi Di Paolo, Laura Tanturri de Horatio, Clara Malattia, Silvia Magni-Manzoni, Karen Rosendahl
Hip involvement is common and estimated to occur in approximately 35-63% of children with juvenile idiopathic arthritis (JIA). It is more prevalent in the aggressive systemic subtypes, with irreversible changes occurring as early as within 5 years of diagnosis. Whilst clinical parameters and joint examination can be useful for assessing disease severity, subclinical disease is known to exist and delayed treatment may herald a lifetime of disability and pain. Early recognition of JIA changes is therefore crucial in determining treatment options...
June 2018: Pediatric Radiology
https://www.readbyqxmd.com/read/29766250/juvenile-idiopathic-arthritis-the-role-of-imaging-from-a-rheumatologist-s-perspective
#15
REVIEW
Clara Malattia, Nikolay Tzaribachev, J Merlijn van den Berg, Silvia Magni-Manzoni
Alongside recent advances in treatment strategies for juvenile idiopathic arthritis (JIA), paediatric rheumatologists have taken increasing interest in the use of imaging. Magnetic resonance imaging (MRI) and musculoskeletal ultrasound, by providing more detailed information on disease activity than clinical examination and conventional radiography (CR), have become helpful diagnostic and managerial tools. The growing skeleton, however, with changing appearances over time, is still challenging in the establishment of valid scoring systems for pathological changes...
June 2018: Pediatric Radiology
https://www.readbyqxmd.com/read/29766249/imaging-of-temporomandibular-joint-abnormalities-in-juvenile-idiopathic-arthritis-with-a-focus-on-developing-a-magnetic-resonance-imaging-protocol
#16
REVIEW
Elka Miller, Emilio J Inarejos Clemente, Nikolay Tzaribachev, Saurabh Guleria, Mirkamal Tolend, Arthur B Meyers, Thekla von Kalle, Jennifer Stimec, Bernd Koos, Simone Appenzeller, Linda Z Arvidsson, Eva Kirkhus, Andrea S Doria, Christian J Kellenberger, Tore A Larheim
Inflammation and damage in the temporomandibular joint (TMJ) often develop without clinical symptoms but can lead to severe facial growth abnormalities and impaired health-related quality of life, making early diagnosis of TMJ changes crucial to identify. Inflammatory and osteochondral changes detectable through magnetic resonance imaging (MRI) occur in TMJs of approximately 40% of children with juvenile idiopathic arthritis (JIA), and no other imaging modality or physical method of examination can reliably detect these changes...
June 2018: Pediatric Radiology
https://www.readbyqxmd.com/read/29766248/imaging-of-the-knee-in-juvenile-idiopathic-arthritis
#17
REVIEW
Robert Hemke, Nikolay Tzaribachev, Anouk M Barendregt, J Merlijn van den Berg, Andrea S Doria, Mario Maas
In juvenile idiopathic arthritis (JIA), imaging is increasingly used in clinical practice. In this paper we discuss imaging of the knee, the clinically most commonly affected joint in JIA. In the last decade, a number of important steps have been made in the development of imaging outcome measures in children with JIA knee involvement. Ultrasound is undergoing a fast validation process, which should be accomplished within the next few years. The validation processes of MRI as an imaging biomarker for clinical trials in the JIA knee are at an advanced stage, with important data available on the feasibility, reliability and validity of the Juvenile Arthritis MRI Scoring system...
June 2018: Pediatric Radiology
https://www.readbyqxmd.com/read/29766247/current-status-of-wrist-imaging-in-juvenile-idiopathic-arthritis
#18
REVIEW
Derk Frederik Matthaus Avenarius, Charlotte Nusman, Clara Malattia, Laura Tanturri de Horatio, Karen Rosendahl, Mario Maas, Lil-Sofie Ording Müller
Wrist involvement occurs in about one-quarter of patients diagnosed with juvenile idiopathic arthritis (JIA), increasing to 40% 5 years after diagnosis. The imaging appearances, both for active inflammation and permanent change, differ from those seen in adult rheumatoid arthritis; therefore, a child-specific approach is crucial for correct assessment. In this review article, we provide an update on the current status for imaging wrist JIA, with a focus on evidence-based practice.
June 2018: Pediatric Radiology
https://www.readbyqxmd.com/read/29764966/risk-factors-for-intraarticular-heterotopic-bone-formation-in-the-temporomandibular-joint-in-juvenile-idiopathic-arthritis
#19
Matthew L Stoll, Dina Amin, Kathlyn K Powell, Catherine H Poholek, Rachel H Strait, Inmaculada Aban, Timothy Beukelman, Daniel W Young, Randy Q Cron, Peter D Waite
OBJECTIVE: Intraarticular corticosteroid (IAC) injections are often used to treat temporomandibular joint (TMJ) arthritis associated with juvenile idiopathic arthritis (JIA). One potential complication of IA therapy is heterotopic bone formation (HBF). The purpose of our study was to evaluate risk factors for HBF development in children with JIA who received IA therapy for TMJ arthritis. METHODS: This was a retrospective study of children with JIA who had received ≥ 1 IAC injection into the TMJ...
May 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29761223/serum-profile-of-transferrin-isoforms-in-juvenile-idiopathic-arthritis-a-preliminary-study
#20
Ewa Gruszewska, Magdalena Sienkiewicz, Paweł Abramowicz, Jerzy Konstantynowicz, Monika Gudowska-Sawczuk, Lech Chrostek, Bogdan Cylwik
It is reported that alterations in protein glycosylation are present in adult rheumatic diseases; however, the data related to pediatric rheumatic conditions are very scarce. The aim of this study was to assess the effect of juvenile idiopathic arthritis (JIA) on the serum glycosylation profile of transferrin isoforms. Twenty-five patients with different clinical forms of an active JIA and 22 healthy controls were studied. Serum samples were analyzed by capillary electrophoresis on MINICAP electrophoretic system (Sebia, France) to determine the levels of transferrin isoforms...
May 14, 2018: Rheumatology International
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