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https://www.readbyqxmd.com/read/29223020/depressive-symptoms-impaired-glucose-metabolism-high-visceral-fat-and-high-systolic-blood-pressure-in-a-subgroup-of-women-with-recent-gestational-diabetes
#1
U Ferrari, F Banning, I Freibothe, K Tröndle, V Sacco, C Wichmann, S Reif, S Moschko, A Potzel, C Gar, N N Sommer, D Popp, J Seissler, A Lechner, H Künzel
Women with gestational diabetes (GDM) are a high risk group for early type 2 diabetes (T2D). Depression is a risk factor for T2D in the general population. We investigated in women after a recent pregnancy with GDM and without a clinical diagnosis of depression, whether mild to moderate depressive symptoms associate with pathologic glucose metabolism. In a cross-sectional analysis, we examined 173 women, 9 ± 3 months after delivery with several psychopathological assessments, 5-point oral glucose tolerance test with insulin, anthropometrics, and laboratory chemistry...
December 5, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29222384/13-management-of-diabetes-in-pregnancy-standards-of-medical-care-in-diabetes-2018
#2
REVIEW
(no author information available yet)
The American Diabetes Association (ADA) "Standards of Medical Care in Diabetes" includes ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Committee, a multidisciplinary expert committee, are responsible for updating the Standards of Care annually, or more frequently as warranted. For a detailed description of ADA standards, statements, and reports, as well as the evidence-grading system for ADA's clinical practice recommendations, please refer to the Standards of Care Introduction Readers who wish to comment on the Standards of Care are invited to do so at professional...
January 2018: Diabetes Care
https://www.readbyqxmd.com/read/29219889/the-value-of-neutrophil-to-lymphocyte-ratio-and-platelet-to-lymphocyte-ratio-for-detecting-early-onset-neonatal-sepsis
#3
Emrah Can, Şahin Hamilcikan, Ceren Can
OBJECTIVE: The purpose of this study was to investigate the relationship between neonate early-onset sepsis (EOS) and the neutrophil to lymphocyte ratio (NLR) and the platelet to lymphocyte ratio (PLR) of term neonates. MATERIALS AND METHODS: This prospective observational study was conducted with term neonates diagnosed with EOS compared with 44 healthy controls. Exclusion criteria were prematurity, postmaturity, small or large for gestational age according to week of pregnancy, preeclampsia, gestational diabetes mellitus, chorioamnionitis, congenital major anomalies, and cyanotic congenital heart disease...
December 6, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29218703/epidemic-of-large-babies-highlighted-by-use-of-intergrowth21st-international-standard
#4
Felicity J Park, Brad de Vries, Jon A Hyett, Adrienne Gordon
OBJECTIVE: To compare birth weights in central Sydney to the INTERGROWTH21st international standard to describe current trends in relation to optimal growth and to define areas that may benefit from improved obstetric surveillance and intervention. METHODS: Retrospective analysis of prospectively collected cohort. DESIGN: hospital-based cohort study. SETTING: Sydney Local Health District, Australia. POPULATION OR SAMPLE: women with singleton pregnancies who had first trimester screening for aneuploidy between 16 April, 2010 and 9 March, 2012...
December 8, 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29218028/the-folate-cycle-as-a-cause-of-natural-killer-cell-dysfunction-and-viral-etiology-in-type-1-diabetes
#5
Allison L Bayer, Christopher A Fraker
The folate pathway is critical to proper cellular function and metabolism. It is responsible for multiple functions, including energy (ATP) production, methylation reactions for DNA and protein synthesis and the production of immunomodulatory molecules, inosine and adenosine. These play an important role in immune signaling and cytotoxicity. Herein, we hypothesize that defects in the folate pathway in genetically susceptible individuals could lead to immune dysfunction, permissive environments for chronic cyclical latent/lytic viral infection, and, ultimately, the development of unchecked autoimmune responses to infected tissue, in this case islet beta cells...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29217485/developmental-origins-of-adult-health-and-disease-the-metabolic-role-of-bdnf-from-early-life-to-adulthood
#6
REVIEW
Despina D Briana, Ariadne Malamitsi-Puchner
Accumulating evidence suggests that the origins of adult disease may occur during fetal life. Thus, the concept of "developmental programming" has been introduced and supported by epidemiological and experimental data. This concept supports the idea that the nutritional and hormonal status during pregnancy could interfere in metabolism control. The mechanisms responsible for this "developmental programming" remain poorly documented. Current research indicates that neurotrophins and particularly brain-derived neurotrophic factor (BDNF) may play a crucial role in this process...
December 4, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29217291/pregnancy-outcomes-in-adult-patients-with-dermatomyositis-and-polymyositis
#7
Kathleen D Kolstad, David Fiorentino, Shufeng Li, Eliza F Chakravarty, Lorinda Chung
OBJECTIVE: The idiopathic inflammatory myopathies dermatomyositis (DM) and polymyositis (PM) are autoimmune diseases that can affect females of childbearing potential. We assessed pregnancy outcomes in DM and PM patients compared with the general obstetric population. METHODS: The Nationwide Inpatient Sample (NIS) (1993-2007) was used to identify delivery-associated hospitalizations in women with DM or PM (DM/PM, n = 853). Controls were from the general obstetric population delivery-associated hospitalizations matched to each case by year of delivery...
November 20, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29216770/maternal-age-over-40-years-and-pregnancy-outcome-a-hospital-based-survey
#8
Luca Marozio, Elisa Picardo, Claudia Filippini, Erika Mainolfi, Paola Berchialla, Franco Cavallo, Annalisa Tancredi, Chiara Benedetto
OBJECTIVE: Increased risk for adverse pregnancy outcomes with advancing maternal age has been described but the strength of association remains debated, particularly in presence of confounding factors such as parity, twin pregnancy and pregnancy from assisted reproductive technologies. The aim of this study was to evaluate pregnancy outcomes in a large cohort of women aged over 40 years. The hypothesis was that advanced maternal age may be an independent risk factor for adverse pregnancy outcome...
December 7, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29216009/the-first-trimester-aneuploidy-biochemical-markers-in-ivf-icsi-patients-have-no-additional-benefit-compared-to-spontaneous-conceptions-in-the-prediction-of-pregnancy-complications
#9
Iwona Szymusik, Przemyslaw Kosinski, Katarzyna Kosinska-Kaczynska, Damian Warzecha, Anetta Karwacka, Bartosz Kaczynski, Miroslaw Wielgos
OBJECTIVES: The aim of this study was to determine if the levels of biochemical aneuploidy markers in in vitro fertilisation (IVF)/intracytoplasmic sperm injection (ICSI) pregnancies differ from those in spontaneous pregnancies and to verify if biochemical markers could predict pregnancy outcome in IVF/ICSI gestations. METHODS: This was a prospective observational study performed in a group of 551 patients who underwent a combined first trimester prenatal screening (ultrasound scan and serum markers)...
December 7, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/29215149/pregnancy-outcomes-in-women-on-metformin-for-diabetes-or-other-indications-among-those-seeking-teratology-information-services
#10
Alice Panchaud, Valentin Rousson, Thierry Vial, Nathalie Bernard, David Baud, Emmanuelle Amar, Marco De Santis, Alessandra Pistelli, Anne Dautriche, Frederique Beau-Salinas, Matteo Cassina, Hannah Dunstan, Anneke Passier, Yusuf Cem Kaplan, Mine Kadioglu Duman, Eva Maňáková, Georgios Eleftheriou, Gil Klinger, Ursula Winterfeld, Laura E Rothuizen, Thierry Buclin, Chantal Csajka, Sonia Hernandez-Diaz
BACKGROUND: Metformin is used to treat type 2 diabetes, polycystic ovary syndrome associated infertility, and gestational diabetes. Human studies evaluating the safety of metformin in early pregnancy are scarce. METHOD: We evaluated the risk of major birth defects and pregnancy losses in a cohort of pregnant women exposed to metformin during first trimester for different indications relative to a matched unexposed reference group. RESULTS: The risk of major birth defects was 5...
December 7, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29212591/-pregnancy-after-bariatric-surgery
#11
Mette Mandrup Kjær, Lise Lotte Torvin-Andersen, Peter Dam, Dorte Møller Jensen, Jeanette Lauenborg, Louise Laage Stentebjerg, René Klinkeby Støving, Kristina Martha Renault
This is a review of the recommendations regarding pregnancy after bariatric surgery from the Danish Society of Obstetrics and Gynaecology. The risk of vitamin/mineral deficiencies should be emphasized and checked with blood samples. Measurements of fetal growth should be offered at gestational age 28 and 34 as a supplement to the standard prenatal procedures because of the increased risk of intrauterine growth retardation. Because of persistent obesity there is still an increased risk of hypertension and diabetes mellitus...
December 4, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29212472/autism-risk-classification-using-placental-chorionic-surface-vascular-network-features
#12
Jen-Mei Chang, Hui Zeng, Ruxu Han, Ya-Mei Chang, Ruchit Shah, Carolyn M Salafia, Craig Newschaffer, Richard K Miller, Philip Katzman, Jack Moye, Margaret Fallin, Cheryl K Walker, Lisa Croen
BACKGROUND: Autism Spectrum Disorder (ASD) is one of the fastest-growing developmental disorders in the United States. It was hypothesized that variations in the placental chorionic surface vascular network (PCSVN) structure may reflect both the overall effects of genetic and environmentally regulated variations in branching morphogenesis within the conceptus and the fetus' vital organs. This paper provides sound evidences to support the study of ASD risks with PCSVN through a combination of feature-selection and classification algorithms...
December 6, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/29212463/could-a-remarkable-decrease-in-leptin-and-insulin-levels-from-colostrum-to-mature-milk-contribute-to-early-growth-catch-up-of-sga-infants
#13
Marina Nunes, Clécio Homrich da Silva, Vera Lucia Bosa, Juliana Rombaldi Bernardi, Isabel Cristina Ribas Werlang, Marcelo Zubaran Goldani
BACKGROUND: Breast milk is known to contain many bioactive hormones and peptides, which can influence infant growth and development. In this context, the purpose of this study was to evaluate the influence of different clinical pregnancy conditions on hormone concentrations in colostrum and mature breast milk. METHODS: An observational study was performed with mother-newborn pairs divided into five groups according to maternal clinical background: diabetes (12), hypertension (5), smoking (19), intrauterine growth restriction of unknown causes with small-for-gestational-age newborns at delivery (12), and controls (21)...
December 6, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29212386/efficacy-and-safety-of-sotagliflozin-in-treating-diabetes-type-1
#14
Marc S Rendell
INTRODUCTION: Sotagliflozin is the first dual SGLT1/SGLT2 inhibitor developed for use in diabetes. Sotagliflozin blocks SGLT2 in the kidneys and SGLT1 in the intestines resulting in reduced early phase glucose absorption and increased blood levels of GLP-1 and PYY. Urinary glucose excretion is lower than with other agents as a result of decreased glucose absorption. The primary development effort to date has been in Type 1 diabetes. AREAS COVERED: The published information on sotagliflozin is reviewed, along with the recent results of several pivotal Type 1 diabetes trials...
December 7, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29211491/complications-and-care-related-to-pregnancy-labor-and-delivery-among-active-component-service-women-u-s-armed-forces-2012-2016
#15
Shauna Stahlman, Catherine T Witkop, Leslie L Clark, Stephen B Taubman
Diagnoses of "complications of pregnancy, childbirth, and the puerperium" include both morbid complications and indications for routine care of pregnant women. During 2012-2016, a total of 55,601 U.S. service members with live births (n=63,879) had 657,060 medical encounters with primary diagnoses of "pregnancy complications." The most frequent diagnoses were "other" specified conditions complicating pregnancy, childbirth, or the puerperium. Numbers of medical encounters with a primary (first-listed) diagnosis of any pregnancy-related complication or indication for care decreased marginally each year between 2012 (n=178,703) and 2016 (n=146,282)...
November 2017: MSMR
https://www.readbyqxmd.com/read/29210999/adverse-intrauterine-environment-and-cardiac-mirna-expression
#16
REVIEW
Mitchell C Lock, Kimberley J Botting, Ross L Tellam, Doug Brooks, Janna L Morrison
Placental insufficiency, high altitude pregnancies, maternal obesity/diabetes, maternal undernutrition and stress can result in a poor setting for growth of the developing fetus. These adverse intrauterine environments result in physiological changes to the developing heart that impact how the heart will function in postnatal life. The intrauterine environment plays a key role in the complex interplay between genes and the epigenetic mechanisms that regulate their expression. In this review we describe how an adverse intrauterine environment can influence the expression of miRNAs (a sub-set of non-coding RNAs) and how these changes may impact heart development...
December 6, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29210994/iron-supplementation-during-pregnancy-and-infancy-uncertainties-and-implications-for-research-and-policy
#17
REVIEW
Patsy M Brannon, Christine L Taylor
Iron is particularly important in pregnancy and infancy to meet the high demands for hematopoiesis, growth and development. Much attention has been given to conditions of iron deficiency (ID) and iron deficient anemia (IDA) because of the high global prevalence estimated in these vulnerable life stages. Emerging and preliminary evidence demonstrates, however, a U-shaped risk at both low and high iron status for birth and infant adverse health outcomes including growth, preterm birth, gestational diabetes, gastrointestinal health, and neurodegenerative diseases during aging...
December 6, 2017: Nutrients
https://www.readbyqxmd.com/read/29209815/portrait-of-women-with-type-1-or-type-2-diabetes-of-childbearing-age-attending-diabetes-clinics-in-italy-the-amd-annals-initiative
#18
Marina Scavini, Maria Chiara Rossi, Marco Scardapane, Antonio Nicolucci, Valeria Manicardi, Giuseppina Russo, Paolo Di Bartolo, Carlo B Giorda, Nicoletta Musacchio, Antonio Ceriello, Stefano Genovese, Chiara Molinari, Nicoletta Dozio
AIM: To describe characteristics relevant in case of an unplanned pregnancy for T1D or T2D women of childbearing age. METHODS: We analyzed the 2011 AMD-Annals dataset, compiling information from 300 clinics (28,840 T1D patients and 532,651 T2D patients). A risk score of unfavorable conditions for pregnancy included HbA1c > 8.0%; BMI ≥ 35; systolic BP ≥ 140 mmHg or diastolic BP ≥ 90 mmHg; microalbuminuria/proteinuria; use of statins, ACE inhibitors, ARB; use of diabetes drugs other than metformin/insulin...
December 5, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/29207894/maternal-and-neonatal-outcomes-related-to-iron-supplementation-or-iron-status-a-summary-of-meta-analyses
#19
Sehar Iqbal, Cem Ekmekcioglu
BACKGROUND: Iron deficiency is the most abundant nutritional deficiency in the world and is discussed to be associated with adverse pregnancy outcomes. The objective of this review was to perform an umbrella summary of meta-analyses to evaluate the effects and associations of iron supplementation or iron status on maternal and birth/neonatal outcomes. METHODS: A literature search was conducted on PubMed and Scopus by two reviewers without temporal restriction. Systematic reviews and meta-analyses of studies evaluating (1) the effects of multimicronutrient compared to iron + folic acid supplementations on maternal and birth/neonatal outcomes (2), the association of dietary iron intake or hemoglobin or ferritin status regarding the risk for maternal (gestational diabetes mellitus (GDM)) and birth/neonatal outcomes, and (3) the effects of iron supplementation on pregnancy and birth/neonatal outcomes, were included in this review...
December 5, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29207220/-long-term-outcome-of-renal-function-in-women-with-preeclampia-and-pregestational-diabetes
#20
REVIEW
Carmela Vadalà, Valeria Cernaro, Rossella Siligato, Roberta Granese, Antonio Simone Laganà, Michele Buemi, Domenico Santoro
Pre-eclampsia (PE) is an important cause of acute renal failure and an important risk marker for subsequent chronic kidney disease. In normal pregnancy, there are marked changes in the renin-angiotensin system (RAS) including considerably elevated angiotensin II (ang II) levels. However, vascular resistance decreases markedly during normal pregnancy, suggesting that pregnant individuals are less sensitive to ang II than non-pregnant individuals. In contrast, during PE decreased circulating components of the RAS with enhanced sensitivity of ang II infusion have been reported...
December 5, 2017: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
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