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JOURNAL ARTICLE
Jinyi Zhou, Jinting Wu, Fangda Fu, Sai Yao, Wenbiao Zheng, Weibin Du, Huan Luo, Hongting Jin, Peijian Tong, Chengliang Wu, Hongfeng Ruan
α-Solanine has been shown to exhibit anti-inflammatory and anti-tumour properties; however, its efficacy in treating osteoarthritis (OA) remains ambiguous. The study aimed to evaluate the therapeutic effects of α-solanine on OA development in a mouse OA model. The OA mice were subjected to varying concentrations of α-solanine, and various assessments were implemented to assess OA progression. We found that α-solanine significantly reduced osteophyte formation, subchondral sclerosis and OARSI score...
February 2024: Journal of Cellular and Molecular Medicine
#22
REVIEW
Jimil Shah, Abhirup Chatterjee, Truptesh H Kothari
Chronic pancreatitis (CP) is an irreversible and progressive inflammation of the pancreas that can involve both pancreatic parenchyma and the pancreatic duct. CP results in morphological changes in the gland in the form of fibrosis and calcification along with functional impairment in the form of exocrine and endocrine insufficiency. Studies on the natural history of CP reveal the irreversibility of the condition and the resultant plethora of complications, of which pancreatic adenocarcinoma is the most dreaded one...
January 30, 2024: Diagnostics
#23
JOURNAL ARTICLE
Chien-Liang Chen, En-Shao Liou, Ming-Ting Wu
INTRODUCTION: Denosumab preceding elective surgery is an alternative option when parathyroidectomy is not immediately possible. Denosumab (an osteoprotegerin mimic) may play a role in the cardiovascular system, which is reflected in the features of epicardial adipose tissue (EAT) and coronary artery calcification (CAC). METHODS: We investigated the effects of denosumab on EAT attenuation (EATAT) and CAC in dialysis patients with secondary hyperparathyroidism (SHPT)...
February 7, 2024: Cardiorenal Medicine
#24
JOURNAL ARTICLE
Roberto Castricini, Olimpio Galasso, Michele Mercurio, Luca Dei Giudici, Alessandro Massarini, Marco De Gori, Davide Castioni, Giorgio Gasparini
BACKGROUND: The medium-term results of reverse shoulder arthroplasty (RSA) that has been performed by a single surgeon have been previously reported. The purpose of this study was to investigate the minimum 10-year clinical and radiographic outcomes of these patients. METHODS: In this prospective cohort study, 27 patients were evaluated after RSA for massive rotator cuff tear with or without eccentric osteoarthritis (OA) or concentric OA with the Constant-Murley Score (CMS), range of motion (ROM), and a radiologic assessment...
January 2024: JSES international
#25
JOURNAL ARTICLE
Paul Rothenberg, Santiago Joaquin Lopez, Dylan Thibault, Lakshmikumar Pillai, Samantha Danielle Minc
OBJECTIVE: Carotid artery stent (CAS) occlusion is a rare complication not well studied. We used a national dataset to assess real world CAS experience to determine the rate of stent occlusion. The purpose of this study was to: 1) Identify risk factors associated with CAS occlusion on long-term follow-up (LTFU) and 2) Determine the adjusted odds of death/transient ischemic attack (TIA)/stroke (CVA) in patients with occlusion. METHODS: The national VQI CAS dataset (2016-2021) comprised the sample...
January 31, 2024: Annals of Vascular Surgery
#26
JOURNAL ARTICLE
Vishal Singh Guleria, Neha Quadri, Keshava Prasad, Ranajit Das, Priyanka Upadhyai
BACKGROUND: Spondyloepimetaphyseal dysplasia with joint laxity type 3 (SEMDJL3) is a rare skeletal dysplasia associated with EXOC6B, a component of the exocyst complex, involved in vesicle tethering and exocytosis at the plasma membrane. So far, EXOC6B and the pathomechanisms underlying SEMDJL3 remain obscure. METHODS AND RESULTS: Exoc6b was detected largely at the perinuclear regions and the primary cilia base in ATDC5 prechondrocytes. Its shRNA lentiviral knockdown impeded primary ciliogenesis...
February 2, 2024: Molecular Biology Reports
#27
JOURNAL ARTICLE
Arun H S Kumar
BACKGROUND: Sortilin1 (SORT1) is a ubiquitously expressed transporter involved in sorting or clearing proteins and is pathologically linked to tissue fibrosis and calcification. Targeting SORT1 may have potential clinical efficacy in controlling or reversing cardiovascular fibrosis and/or calcification. Hence, this study assessed the protein-protein network of human SORT1 and its targetability using known nutra-/pharmaceuticals. MATERIAL AND METHODS: Network proteins of human SORT1 were identified using the String database, and the affinity of the protein-protein interaction of this network was analysed using Chimera software (Chimera-1...
January 18, 2024: Life
#28
JOURNAL ARTICLE
Jieyu He, Yanjiao Wang, Junkun Zhan, Shuang Li, Yuqing Ni, Wu Huang, Limin Long, Pan Tan, Yi Wang, Youshuo Liu
OBJECTIVE: To investigate the relationship between icariin and the osteoblastic differentiation of vascular smooth muscle cells (VSMCs) and the signal pathway involved. METHODS: We applied a universally accepted calcification model of VSMCs induced by β glycerophosphate. Then the VSMCs calcification was observed by treatment with icariin and/or inhibitors of estrogen receptors (ERs) and p38-mitogen-activated protein kinase (MAPK) signaling. RESULTS: Icariin inhibited osteoblastic differentiation and mineralization of VSMCs due to decreased ALP activity and Runx2 expression...
December 2023: Aging medicine
#29
JOURNAL ARTICLE
André Luiz Cerqueira Almeida, Marcelo Dantas Tavares de Melo, David Costa de Souza Le Bihan, Marcelo Luiz Campos Vieira, José Luiz Barros Pena, José Maria Del Castillo, Henry Abensur, Renato de Aguiar Hortegal, Maria Estefania Bosco Otto, Rafael Bonafim Piveta, Maria Rosa Dantas, Jorge Eduardo Assef, Adenalva Lima de Souza Beck, Thais Harada Campos Espirito Santo, Tonnison de Oliveira Silva, Vera Maria Cury Salemi, Camila Rocon, Márcio Silva Miguel Lima, Silvio Henrique Barberato, Ana Clara Rodrigues, Arnaldo Rabschkowisky, Daniela do Carmo Rassi Frota, Eliza de Almeida Gripp, Rodrigo Bellio de Mattos Barretto, Sandra Marques E Silva, Sanderson Antonio Cauduro, Aurélio Carvalho Pinheiro, Salustiano Pereira de Araujo, Cintia Galhardo Tressino, Carlos Eduardo Suaide Silva, Claudia Gianini Monaco, Marcelo Goulart Paiva, Cláudio Henrique Fisher, Marco Stephan Lofrano Alves, Cláudia R Pinheiro de Castro Grau, Maria Veronica Camara Dos Santos, Isabel Cristina Britto Guimarães, Samira Saady Morhy, Gabriela Nunes Leal, Andressa Mussi Soares, Cecilia Beatriz Bittencourt Viana Cruz, Fabio Villaça Guimarães Filho, Bruna Morhy Borges Leal Assunção, Rafael Modesto Fernandes, Roberto Magalhães Saraiva, Jeane Mike Tsutsui, Fábio Luis de Jesus Soares, Sandra Nívea Dos Reis Saraiva Falcão, Viviane Tiemi Hotta, Anderson da Costa Armstrong, Daniel de Andrade Hygidio, Marcelo Haertel Miglioranza, Ana Cristina Camarozano, Marly Maria Uellendahl Lopes, Rodrigo Julio Cerci, Maria Eduarda Menezes de Siqueira, Jorge Andion Torreão, Carlos Eduardo Rochitte, Alex Felix
Central Illustration : Position Statement on the Use of Myocardial Strain in Cardiology Routines by the Brazilian Society of Cardiology's Department Of Cardiovascular Imaging - 2023 Proposal for including strain in the integrated diastolic function assessment algorithm, adapted from Nagueh et al.67 Am: mitral A-wave duration; Ap: reverse pulmonary A-wave duration; DD: diastolic dysfunction; LA: left atrium; LASr: LA strain reserve; LVGLS: left ventricular global longitudinal strain; TI: tricuspid insufficiency...
December 2023: Arquivos Brasileiros de Cardiologia
#30
JOURNAL ARTICLE
Guangyu Zhou, Chen Zhang, Hui Peng, Xuesong Su, Qun Huang, Zixia Zhao, Guangyi Zhao
BACKGROUND: Medial vascular calcification is commonly identified in chronic kidney disease (CKD) patients and seriously affects the health and life quality of patients. This study aimed to investigate the effects of protein arginine methyltransferase 3 (PRMT3) on vascular calcification induced by CKD. METHODS: A mice model of CKD was established with a two-step diet containing high levels of calcium and phosphorus. Vascular smooth muscle cells (VSMCs) were subjected to β-glycerophosphate (β-GP) treatment to induce the osteogenic differentiation as an in vitro CKD model...
January 10, 2024: Molecular Medicine
#31
JOURNAL ARTICLE
Jinmi Lee, Seok-Woo Hong, Min-Jeong Kim, Sun Joon Moon, Hyemi Kwon, Se Eun Park, Eun-Jung Rhee, Won-Young Lee
BACKGROUND: Glucagon-like peptide-1 receptor agonist (GLP-1RA), which is a therapeutic agent for the treatment of type 2 diabetes mellitus, has a beneficial effect on the cardiovascular system. METHODS: To examine the protective effects of GLP-1RAs on proliferation and migration of vascular smooth muscle cells (VSMCs), A-10 cells exposed to angiotensin II (Ang II) were treated with either exendin-4, liraglutide, or dulaglutide. To examine the effects of GLP-1RAs on vascular calcification, cells exposed to high concentration of inorganic phosphate (Pi) were treated with exendin-4, liraglutide, or dulaglutide...
January 3, 2024: Diabetes & Metabolism Journal
#32
JOURNAL ARTICLE
Qing-Qing Dong, Yu-Chi Tu, Pan Gao, Qian-Qian Liao, Peng Zhou, Hui Zhang, Hua-Pan Shu, Lu-Lu Sun, Li Feng, Li-Jun Yao
Rationale: Vascular calcification (VC) is a life-threatening complication in patients with chronic kidney disease (CKD) caused mainly by hyperphosphatemia. However, the regulation of VC remains unclear despite extensive research. Although serum- and glucocorticoid-induced kinase 3 (SGK3) regulate the sodium-dependent phosphate cotransporters in the intestine and kidney, its effect on VC in CKD remains unknown. Additionally, type III sodium-dependent phosphate cotransporter-1 (Pit-1) plays a significant role in VC development induced by high phosphate in vascular smooth muscle cells (VSMCs)...
2024: Theranostics
#33
JOURNAL ARTICLE
Yujing Wang, Min Xiao, Feng Cai, Yang Li, Tianli Shi, Xiaoyan Zhou, Shuhong Tian, Denggao Huang
Vascular calcification (VC) is a common complication of chronic kidney disease (CKD). VC is a gene-regulated process similar to osteogenic differentiation. There are still no convincing schemes to prevent and reduce the development of VC. It has been reported that hypoxia-inducing factor 1α (HIF-1α) and endothelin-1(ET-1) are related to VC. In this study, we found that the expression of ET-1 and HIF-1α was enhanced after VC, the interaction between HIF-1α and ET-1 was confirmed by CO-IP and luciferase experiments...
December 29, 2023: Environmental Toxicology
#34
JOURNAL ARTICLE
Joseph V Madrid, Madeline K M Vera-Colón, Nicole I Zur Nieden
Tobacco smoke contains between 7000 and 10,000 constituents, and only an evanescently low number of which have been identified, let alone been evaluated for their toxicity. Recently, the Food and Drug Administration has published a list of 93 chemical tobacco constituents that are harmful or potentially harmful to a number of cellular processes. However, their effect on developing skeletal cells is unknown. In this study, we used ToxPI, a computational tool, to prioritize constituents on this list for screening in osteogenically differentiating human embryonic stem cells and fibroblasts...
December 7, 2023: Toxics
#35
REVIEW
Emmanuelle Vermes, Laura Iacuzio, Sylvestre Maréchaux, Franck Levy, Claudia Loardi, Christophe Tribouilloy
Patients with biological aortic valves (following either surgical aortic valve replacement [SAVR] or trans catheter aortic valve implantation [TAVI]) require lifelong follow-up with an imaging modality to assess prosthetic valve function and dysfunction. Echocardiography is currently the first-line imaging modality to assess biological aortic valves. In this review, we discuss the potential role of cardiac magnetic resonance imaging (CMR) as an additional imaging modality in situations of inconclusive or equivocal echocardiography...
2023: Frontiers in Cardiovascular Medicine
#36
JOURNAL ARTICLE
Meng Meng, Jiaying Wang, Changyuan Wang, Jianyu Zhao, Huihan Wang, Yukun Zhang, Huijun Sun, Mozhen Liu
In hyperlipidemia-induced osteoporosis, bone marrow mesenchymal stem cells (BMSCs) differentiate into more adipocytes than osteoblasts, leading to decreased bone formation. It is vital to elucidate the effects of hyperlipidemia on bone metabolism and seek new agents that regulate adipocyte-osteoblast lineage allocation. CoQ10, a rate-limiting coenzyme of the mitochondrial respiratory chain, has been reported to decrease oxidative stress and lipid peroxidation by functioning as a mitochondrial antioxidant. However, its effect on hyperlipidemia-induced osteoporosis remains unknown...
December 6, 2023: Calcified Tissue International
#37
JOURNAL ARTICLE
Wei Huang, Yingqi Xiao, Li Zhang, Hu Liu
This study aimed to examine the association between sex hormone-binding globulin (SHBG) and osteoporosis through a cross-sectional study and a two-sample bidirectional Mendelian randomization (MR). We used the National Health and Nutrition Examination Survey (NHANES) 2013-2014 and 2015-2016 data, with exposure as serum SHBG and outcome as osteoporosis and performed multivariate logistic regression to test the correlation between SHBG and osteoporosis. To determine the causal relationship between SHBG and osteoporosis, a two-sample bidirectional MR was employed...
December 5, 2023: Calcified Tissue International
#38
JOURNAL ARTICLE
Titus Andrian, Anca Stefan, Ionut Nistor, Adrian Covic
Vitamin K supplementation has been considered recently as a potential treatment for addressing vascular calcification in chronic kidney disease patients. We conducted a systematic review and meta-analysis to summarize the impact of vitamin K supplementation in dialysis patients. Electronic databases were searched for clinical randomized trials among patients treated with vitamin K. Random effects models were performed and risk of bias was evaluated with Cochrane tools and the search was conducted until 15 of September 2023...
December 2023: Clinical Kidney Journal
#39
Gerald S Werner, Kenji Yaginuma
BACKGROUND: Severe calcifications are a major reason for failures in chronic total coronary occlusions, as they can obstruct the wire passage both in the antegrade and retrograde technique. CASE SUMMARY: The proximal occlusion of the left anterior descending artery in a 75-year-old man presented with a completely concentric calcified ring all along the segment proximal to the occlusion. The antegrade wire could not pass the calcified occlusion, and in a retrograde approach via the right posterior descending artery the retrograde wire was not able to enter the lumen from a subintimal position outside of the calcified ring...
November 2023: European Heart Journal. Case Reports
#40
JOURNAL ARTICLE
Jiangyong Yang, Guojun Jiang, Ling Huang, Zhongyi Liu, Rengui Jiang, Gang Cao, Jun Cao, Hengqing Zhu, Lemei Chen, Xiaoming Chen, Fang Pei
Long non-coding RNAs (LncRNAs) have been found to play a regulatory role in the pathophysiology of vascular remodeling-associated illnesses through the lncRNA-microRNA (miRNA) regulation axis. LncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is thought to be involved in proliferation, migration, apoptosis, and calcification of vascular smooth muscle cells (VSMCs). The purpose of this study was to investigate the regulatory role of MALAT1 on vascular remodeling in hypertension. Our data indicate that the expression of MALAT1 is significantly upregulated in hypertensive aortic smooth muscle...
December 31, 2023: Clinical and Experimental Hypertension: CHE
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