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Reversing calcification

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https://www.readbyqxmd.com/read/27876618/tlr4-nf-%C3%AE%C2%BAb-ceramide-signaling-contributes-to-ox-ldl-induced-calcification-of-human-vascular-smooth-muscle-cells
#1
Yan Song, Menglin Hou, Zhenlin Li, Chufan Luo, Jing-Song Ou, Huimin Yu, Jianyun Yan, Lihe Lu
Vascular calcification is a major feature of advanced atherosclerosis and highly associated with cardiovascular diseases. Oxidized low density lipoprotein (Ox-LDL) has been recognized as a critical risk factor for atherosclerosis and osteogenic differentiation of vascular smooth muscle cells (VSMCs). Previous studies have demonstrated that toll like receptor 4 (TLR4) is highly expressed in atherosclerotic lesions and participates in the progression of atherosclerosis. However, the role of TLR4 in vascular calcification remains unknown...
November 19, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27866029/understanding-the-structural-features-of-symptomatic-calcific-aortic-valve-stenosis-a-broad-spectrum-clinico-pathologic-study-in-236-consecutive-surgical-cases
#2
Daniela Galli, Roberta Manuguerra, Rodolfo Monaco, Laura Manotti, Matteo Goldoni, Gabriella Becchi, Cecilia Carubbi, Giulia Vignali, Nicola Cucurachi, Tiziano Gherli, Francesco Nicolini, Roberto Lorusso, Marco Vitale, Domenico Corradi
BACKGROUND: With age, aortic valve cusps undergo varying degrees of sclerosis which, sometimes, can progress to calcific aortic valve stenosis (AVS). To perform a retrospective clinico-pathologic investigation in patients with calcific AVS. METHODS: We characterized and graded the structural remodeling in 236 aortic valves (200 tricuspid and 36 bicuspid) from patients with calcific AVS (148 males; average 72years); possible relationships between general/clinical/echocardiographic characteristics and the histopathologic changes were explored...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27835878/apocynin-attenuates-angiotensin-ii-induced-vascular-smooth-muscle-cells-osteogenic-switching-via-suppressing-extracellular-signal-regulated-kinase-1-2
#3
Weijing Feng, Kun Zhang, Yu Liu, Jie Chen, Qingqing Cai, Yinyin Zhang, Mongheng Wang, Jingfeng Wang, Hui Huang
Vascular calcification (VC) is a significant risk factor for cardiovascular morbidity and mortality. We recently reported that apocynin had benefits for preventing cardiovascular diseases. However, whether apocynin could attenuate VC is unknown. Here, we investigated the role of apocynin in VC and its underlying mechanisms. 163 participants with high or normal ankle-brachial index (ABI) were enrolled in this study for analyzing the demographic and biochemical data. In vitro, vascular smooth muscle cells (VSMCs) were exposed to calcification medium containing b-glycerophosphate and angiotensin II (Ang II) for 24 hours...
November 8, 2016: Oncotarget
https://www.readbyqxmd.com/read/27776971/association-between-vascular-calcification-assessed-by-simple-radiography-and-non-fatal-cardiovascular-events-in-hemodialysis-patients
#4
Vaida Petrauskiene, Ruta Vaiciuniene, Inga Arune Bumblyte, Vytautas Kuzminskis, Edita Ziginskiene, Saulius Grazulis, Egle Jonaitiene
BACKGROUND: Vascular calcification (VC) is one of the factors associated with cardiovascular mortality in hemodialysis (HD) patients. Recommendations concerning screening for VC differ. Possible ability to prevent and reversibility of VC are major subjects on debate whether screening for VC could improve outcomes of renal patients. The objective of the study was to evaluate the significance of simple vascular calcification score (SVCS) based on plane radiographic films and to test its association with non-fatal cardiovascular events in patients on chronic HD...
October 21, 2016: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/27719736/regression-of-vascular-calcification-in-a-parathyroidectomized-patient-on-dialysis-with-untreated-hypocalcemia-over-12-year-follow-up%C3%A2
#5
Pablo Molina, José L Górriz, Sandra Beltrán, Belén Vizcaino, Luis M Pallardo
Although some experimental targets involved in calcium deposition are emerging, no intervention has been described to reliably reverse vascular calcification (VC). We report a case of severe VC regression in a parathyroidectomized patient on hemodialysis over 12-year follow-up, highlighting the use of calcium-free phosphate binders and a 2.5 mEq/L calcium dialysate for reducing calcium loading, despite persistent asymptomatic hypocalcemia occurrences. This case suggests that phosphate-binder choice and calcium dialysate concentration could be influenced by other components of CKD-MBD besides biochemical parameters, such as the presence of VC, so concluding that asymptomatic hypocalcemia may not be as harmful as once supposed, and conferring greater prognostic weight to the presence of VC than to calcium levels...
December 2016: Clinical Nephrology
https://www.readbyqxmd.com/read/27698934/reversal-of-vascular-calcification-and-aneurysms-in-a-rat-model-using-dual-targeted-therapy-with-edta-and-pgg-loaded-nanoparticles
#6
Nasim Nosoudi, Aniqa Chowdhury, Steven Siclari, Saketh Karamched, Vaideesh Parasaram, Joe Parrish, Patrick Gerard, Narendra Vyavahare
Degeneration of elastic lamina and vascular calcification are common features of vascular pathology such as aortic aneurysms. We tested whether dual therapy with targeted nanoparticles (NPs) can remove mineral deposits (by delivery of a chelating agent, ethylene diamine tetraacetic acid (EDTA)) and restore elastic lamina (by delivery of a polyphenol, pentagalloyl glucose (PGG)) to reverse moderate aneurysm development. EDTA followed by PGG NP delivery led to reduction in macrophage recruitment, matrix metalloproteinase (MMP) activity, elastin degradation and calcification in the aorta as compared to delivery of control blank NPs...
2016: Theranostics
https://www.readbyqxmd.com/read/27684601/ocean-acidification-affects-parameters-of-immune-response-and-extracellular-ph-in-tropical-sea-urchins-lytechinus-variegatus-and-echinometra-luccunter
#7
Débora Alvares Leite Figueiredo, Paola Cristina Branco, Douglas Amaral Dos Santos, Andrews Krupinski Emerenciano, Renata Stecca Iunes, João Carlos Shimada Borges, José Roberto Machado Cunha da Silva
The rising concentration of atmospheric CO2 by anthropogenic activities is changing the chemistry of the oceans, resulting in a decreased pH. Several studies have shown that the decrease in pH can affect calcification rates and reproduction of marine invertebrates, but little attention has been drawn to their immune response. Thus this study evaluated in two adult tropical sea urchin species, Lytechinus variegatus and Echinometra lucunter, the effects of ocean acidification over a period of 24h and 5days, on parameters of the immune response, the extracellular acid base balance, and the ability to recover these parameters...
September 17, 2016: Aquatic Toxicology
https://www.readbyqxmd.com/read/27683096/sudden-onset-of-parathyroid-hormone-independent-severe-hypercalcemia-from-reversal-of-tumoral-calcinosis-in-a-dialysis-patient
#8
Fareed B Kamar, Bikaramjit Mann, Gregory Kline
BACKGROUND: Tumoral calcinosis is a rare manifestation of extraskeletal calcification, featuring large calcified cystic masses in the periarticular regions of large joints. In chronic kidney disease (CKD), this disorder is thought to evolve through a chronically elevated calcium-phosphorus solubility product leading to calcium precipitation in soft tissue. Treating tumoral calcinosis in these patients involves interventions to lower the calcium-phosphorus product such as reduction in vitamin D therapy and intensive hemodialysis regimens...
September 29, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27666759/ligand-trap-of-the-activin-receptor-type-iia-inhibits-osteoclast-stimulation-of-bone-remodeling-in-diabetic-mice-with-chronic-kidney-disease
#9
Toshifumi Sugatani, Olga A Agapova, Yifu Fang, Alycia G Berman, Joseph M Wallace, Hartmut H Malluche, Marie-Claude Faugere, William Smith, Victoria Sung, Keith A Hruska
Dysregulation of skeletal remodeling is a component of renal osteodystrophy. Previously, we showed that activin receptor signaling is differentially affected in various tissues in chronic kidney disease (CKD). We tested whether a ligand trap for the activin receptor type 2A (RAP-011) is an effective treatment of the osteodystrophy of the CKD-mineral bone disorder. With a 70% reduction in the glomerular filtration rate, CKD was induced at 14 weeks of age in the ldlr-/- high fat-fed mouse model of atherosclerotic vascular calcification and diabetes...
September 22, 2016: Kidney International
https://www.readbyqxmd.com/read/27621885/a-reverse-direction-technique-of-single-port-left-upper-pulmonary-resection
#10
Min Zhang, Alan D L Sihoe, Ming Du
BACKGROUND: Single-port video-assisted thoracoscopic surgery (VATS) left upper lobectomy is difficult amongst all the lobes. At the beginning of single-port lobectomies, the upper lobes were believed not to be amenable for single-port approach due to the difficult angulation for staplers. Gonzalez reported the first single-port VATS left upper lobectomy in 2011. METHODS: We report a new technique of single-port VATS left upper lobectomy with the concept of "reverse direction"...
August 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27585243/targeting-vasoactive-peptides-for-managing-calcific-aortic-valve-disease
#11
Tuomas Peltonen, Pauli Ohukainen, Heikki Ruskoaho, Jaana Rysä
Calcific aortic valve disease (CAVD) represents a spectrum of disease spanning from milder degrees of calcification of valve leaflets, i.e. aortic sclerosis, to severe calcification i.e. aortic stenosis (AS) with hemodynamic instability. The prevalence of CAVD is increasing rapidly due to the aging of the population, being up to 2,8% among patients over 75 years of age. Even without significant aortic valve stenosis, aortic sclerosis is associated with a 50% increased risk of myocardial infarction and death from cardiovascular causes...
September 1, 2016: Annals of Medicine
https://www.readbyqxmd.com/read/27572900/effects-of-sphingosylphosphorylcholine-on-cryopreserved-fat-tissue-graft-survival
#12
Yong Chan Bae, Chi Won Choi, Kyeong Wook Nam, Ji Sun Song, Jae Woo Lee
Autogenous microfat grafting is widely used to augment depressed deformities or for other cosmetic purposes. Since the microfat survival rate is unpredictable due to absorption and calcification, previously cryopreserved fat is widely used for secondary procedures. Sphingosylphosphorylcholine (SPC) is a lysophospholipid, which has a role in several cellular responses, and is known to stimulate DNA synthesis and proliferation. Since endothelial progenitor cells (EPCs) are known to enhance the survival rate of transplanted fat tissue, the present study assessed the effects of SPC on EPCs, in order to verify its positive effects on proliferation...
October 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27559830/update-interim-guidance-for-the-evaluation-and-management-of-infants-with-possible-congenital-zika-virus-infection-united-states-august-2016
#13
Kate Russell, Sara E Oliver, Lillianne Lewis, Wanda D Barfield, Janet Cragan, Dana Meaney-Delman, J Erin Staples, Marc Fischer, Georgina Peacock, Titilope Oduyebo, Emily E Petersen, Sherif Zaki, Cynthia A Moore, Sonja A Rasmussen
CDC has updated its interim guidance for U.S. health care providers caring for infants born to mothers with possible Zika virus infection during pregnancy (1). Laboratory testing is recommended for 1) infants born to mothers with laboratory evidence of Zika virus infection during pregnancy and 2) infants who have abnormal clinical or neuroimaging findings suggestive of congenital Zika syndrome and a maternal epidemiologic link suggesting possible transmission, regardless of maternal Zika virus test results...
2016: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/27461215/can-intestinal-phosphate-binding-or-inhibition-of-hydroxyapatite-growth-in-the-vascular-wall-halt-the-progression-of-established-aortic-calcification-in-chronic-kidney-disease
#14
Ellen Neven, Britt Opdebeeck, Annelies De Maré, Rida Bashir-Dar, Geert Dams, Rita Marynissen, Geert J Behets, Anja Verhulst, Bruce L Riser, Patrick C D'Haese
Vascular calcification significantly contributes to mortality in chronic kidney disease (CKD) patients. Sevelamer and pyrophosphate (PPi) have proven to be effective in preventing vascular calcification, the former by controlling intestinal phosphate absorption, the latter by directly interfering with the hydroxyapatite crystal formation. Since most patients present with established vascular calcification, it is important to evaluate whether these compounds may also halt or reverse the progression of preexisting vascular calcification...
November 2016: Calcified Tissue International
https://www.readbyqxmd.com/read/27447569/etidronate-prevents-but-does-not-reverse-ectopic-mineralization-in-a-mouse-model-of-pseudoxanthoma-elasticum-abcc6
#15
Qiaoli Li, Joshua Kingman, John P Sundberg, Michael A Levine, Jouni Uitto
Pseudoxanthoma elasticum (PXE) and generalized arterial calcification of infancy (GACI) are heritable disorders manifesting with ectopic tissue mineralization. Most cases of PXE and some cases of GACI are caused by mutations in the ABCC6 gene, resulting in reduced plasma pyrophosphate (PPi) levels. There is no effective treatment for these disorders. It has been suggested that administration of bisphosphonates, stable and non-hydrolyzable PPi analogs, could counteract ectopic mineralization in these disorders...
July 20, 2016: Oncotarget
https://www.readbyqxmd.com/read/27431734/silencing-of-osterix-expression-by-sirna-inhibits-aldosterone%C3%A2-induced-calcification-of-vascular-smooth-muscle-cells-in-mice
#16
Yan-Chun Gong, Yue He, Hao Wang, Wen-Quan Niu, Kai-Da Ji, Hua Li
The process of vascular calcification shares numerous similarities with that of skeletal mineralization and involves the deposition of hydroxyapatite crystals in arteries and cardiac valves. However, the underlying cellular mechanism remains to be fully elucidated. Microarray analysis in the present study demonstrated that greater than 2,000 genes were upregulated during the calcification of murine vascular smooth muscle cells (VSMCs), of which osterix (OSX) and integrin‑binding sialoprotein (IBSP) were the most significantly differentially expressed genes...
September 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27412937/-mechanism-of-losartan-suppressing-vascular-calcification-in-rat-aortic-artery
#17
Juan Shao, Panfeng Wu, Jiliang Wu, Mincai Li
Objective To investigate the effect of the angiotensin II receptor 1 (AT1R) blocker losartan on vascular calcification in rat aortic artery and explore the underlying mechanisms. Methods SD rats were divided randomly into control group, vascular calcification model group and treatment group. Vascular calcification models were made by subcutaneous injection of warfarin plus vitamin K1 for two weeks. Rats in the treatment group were subcutaneously injected with losartan (10 mg/kg) at the end of the first week and consecutively for one week...
August 2016: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/27402270/magnesium-inhibits-the-calcification-of-the-extracellular-matrix-in-tendon-derived-stem-cells-via-the-atp-p2r-and-mitochondrial-pathways
#18
Jiaji Yue, Shanzi Jin, Yaqiang Li, Li Zhang, Wenwei Jiang, Chunxi Yang, Jiang Du
Tendon calcification has been widely regarded by researchers to result from the osteogenic differentiation of Tendon-Derived Stem Cells (TDSCs) and ectopic mineralization caused by the calcification of cellular matrix. Recent studies have revealed a correlation between the Mg(2+)/Ca(2+) balance and the degeneration or calcification of tendon tissues. Furthermore, the ATP-P2X/P2Y receptor pathway has been shown to play a decisive role in the process of calcification, with calcium exportation from mitochondria and calcium oscillations potentially representing the cohesive signal produced by this pathway...
September 9, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27374065/dorsomorphin-homologue-1-a-highly-selective-small-molecule-bone-morphogenetic-protein-inhibitor-suppresses-medial-artery-calcification
#19
Tonghui Lin, Xue-Lin Wang, Sara L Zettervall, Yujun Cai, Raul J Guzman
BACKGROUND: Medial artery calcification develops in diabetes, chronic kidney disease, and as part of the aging process. It is associated with increased morbidity and mortality in vascular patients. Bone morphogenetic proteins (BMPs) have previously been implicated in the initiation and progression of vascular calcification. We thus evaluated whether dorsomorphin homologue 1 (DMH1), a highly selective BMP inhibitor, could attenuate vascular calcification in vitro and in an organ culture model of medial calcification...
June 30, 2016: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/27366039/is-pancreatic-exocrine-insufficiency-in-celiac-disease-related-to-structural-alterations-in-pancreatic-parenchyma
#20
Surinder S Rana, Arvind Dambalkar, Puneet Chhabra, Ravi Sharma, Ritambhra Nada, Vishal Sharma, Satyavati Rana, Deepak K Bhasin
BACKGROUND: Although exocrine pancreatic insufficiency (EPI) has been reported in a number of patients with celiac disease (CD), it is not clear if this is primarily a functional or a structural defect. We studied pancreatic structural abnormalities by endoscopic ultrasound (EUS) in adult CD patients with EPI. METHODS: Pancreatic exocrine function was prospectively assessed in 36 recently diagnosed CD patients (mean age: 29.8 years) by measuring fecal elastase. Pancreatic structural changes were assessed in CD patients with EPI by EUS and elastography...
July 2016: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
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