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https://www.readbyqxmd.com/read/28722648/perspectives-on-the-pure-tone-audiogram
#1
REVIEW
Frank E Musiek, Jennifer Shinn, Gail D Chermak, Doris-Eva Bamiou
BACKGROUND: The pure-tone audiogram, though fundamental to audiology, presents limitations, especially in the case of central auditory involvement. Advances in auditory neuroscience underscore the considerably larger role of the central auditory nervous system (CANS) in hearing and related disorders. Given the availability of behavioral audiological tests and electrophysiological procedures that can provide better insights as to the function of the various components of the auditory system, this perspective piece reviews the limitations of the pure-tone audiogram and notes some of the advantages of other tests and procedures used in tandem with the pure-tone threshold measurement...
July 2017: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/28721669/mimicking-parkinson-s-disease-in-a-dish-merits-and-pitfalls-of-the-most-commonly-used-dopaminergic-in-vitro-models
#2
REVIEW
Fernanda Martins Lopes, Ivi Juliana Bristot, Leonardo Lisbôa da Motta, Richard B Parsons, Fabio Klamt
Parkinson's disease (PD) is the second most common neurodegenerative disorder and has both unknown etiology and non-curative therapeutic options. Patients begin to present the classic motor symptoms of PD-tremor at rest, bradykinesia and rigidity-once 50-70% of the dopaminergic neurons of the nigrostriatal pathway have degenerated. As a consequence of this, it is difficult to investigate the early-stage events of disease pathogenesis. In vitro experimental models are used extensively in PD research because they present a controlled environment that enables the direct investigation of the early molecular mechanisms that are potentially involved with dopaminergic degeneration, as well as for the screening of potential therapeutic drugs...
July 18, 2017: Neuromolecular Medicine
https://www.readbyqxmd.com/read/28718304/the-role-of-surgery-in-low-grade-gliomas-do-timing-and-extent-of-resection-matter
#3
Hugues Duffau
Hugues Duffau is a Professor and Chairman of the Neurosurgery Department in the Montpellier University Medical Center and Head of the INSERM 1051 Team "plasticity of the central nervous system, human stem cells and glial tumors" at the Institute for Neurosciences of Montpellier (France). He is an expert in the awake cognitive neurosurgery of slow-growing brain tumors, such as low-grade gliomas, a routine which he has developed since 20 years. His fundamental approach is centered on the concepts of the brain connectomics and neuroplasticity, breaking with the traditional localizationist view of cerebral processing...
July 18, 2017: CNS Oncology
https://www.readbyqxmd.com/read/28714713/promoting-transparency-and-reproducibility-in-behavioral-neuroscience-publishing-replications-registered-reports-and-null-results
#4
Mark G Baxter, Rebecca D Burwell
The editors of Behavioral Neuroscience have been discussing several recent developments in the landscape of scientific publishing. The discussion was prompted, in part, by reported issues of reproducibility and concerns about the integrity of the scientific literature. Although enhanced rigor and transparency in science are certainly important, a related issue is that increased competition and focus on novel findings has impeded the extent to which the scientific process is cumulative. We have decided to join the growing number of journals that are adopting new reviewing and publishing practices to address these problems...
August 2017: Behavioral Neuroscience
https://www.readbyqxmd.com/read/28704833/pica-in-a-child-with-anterior-cingulate-gyrus-oligodendroglioma-case-report
#5
Shivani D Rangwala, Matthew K Tobin, Daniel M Birk, Jonathan T Butts, Dimitrios C Nikas, Yoon S Hahn
The anterior cingulate gyrus (ACG) is a continued focus of research as its exact role in brain function and vast connections with other anatomical locations is not fully understood. A review of the literature illustrates the role the ACG likely plays in cognitive and emotional processing, as well as a modulating role in motor function and goal-oriented behaviors. While lesions of the cingulate gyrus are rare, each new case broadens our understanding of its role in cognitive neuroscience and higher order processing...
July 14, 2017: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28702756/creating-a-common-terminology-for-play-behavior-to-increase-cross-disciplinary-research
#6
Lance J Miller
Historically, play behavior has been difficult to define. This likely stems from the number of different species, types of play, and context under which it occurs. In 2016, the Chicago Zoological Society - Brookfield Zoo hosted the Psychonomic Society leading edge workshop on the evolutionary and psychological significance of play. Sixteen experts attended from the diverse fields of African ethnology, animal behavior, animal science, animal welfare, cognitive psychology, cognitive zoology, comparative psychology, cultural anthropology, developmental psychology, educational psychology, ethology, neuroscience, primatology, and zoology...
July 12, 2017: Learning & Behavior
https://www.readbyqxmd.com/read/28700651/metric-based-vs-peer-reviewed-evaluation-of-a-research-output-lesson-learnt-from-uk-s-national-research-assessment-exercise
#7
Kushwanth Koya, Gobinda Chowdhury
PURPOSE: There is a general inquisition regarding the monetary value of a research output, as a substantial amount of funding in modern academia is essentially awarded to good research presented in the form of journal articles, conferences papers, performances, compositions, exhibitions, books and book chapters etc., which, eventually leads to another question if the value varies across different disciplines. Answers to these questions will not only assist academics and researchers, but will also help higher education institutions (HEIs) make informed decisions in their administrative and research policies...
2017: PloS One
https://www.readbyqxmd.com/read/28696013/the-role-of-diffusion-mri-in-neuroscience
#8
Yaniv Assaf, Heidi Johansen-Berg, Michel Thiebaut de Schotten
Diffusion-weighted imaging has pushed the boundaries of neuroscience by allowing us to examine the white matter microstructure of the living human brain. By doing so, it has provided answers to fundamental neuroscientific questions, launching a new field of research that had been largely inaccessible. We briefly summarize key questions that have historically been raised in neuroscience concerning the brain's white matter. We then expand on the benefits of diffusion-weighted imaging and its contribution to the fields of brain anatomy, functional models and plasticity...
July 11, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28695528/never-forget-negative-emotional-valence-enhances-recapitulation
#9
Holly J Bowen, Sarah M Kark, Elizabeth A Kensinger
A hallmark feature of episodic memory is that of "mental time travel," whereby an individual feels they have returned to a prior moment in time. Cognitive and behavioral neuroscience methods have revealed a neurobiological counterpart: Successful retrieval often is associated with reactivation of a prior brain state. We review the emerging literature on memory reactivation and recapitulation, and we describe evidence for the effects of emotion on these processes. Based on this review, we propose a new model: Negative Emotional Valence Enhances Recapitulation (NEVER)...
July 10, 2017: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/28690553/a-historical-review-of-diachrony-and-semantic-dimensions-of-trace-in-neurosciences-and-lacanian-psychoanalysis
#10
REVIEW
Carolina Escobar, François Ansermet, Pierre J Magistretti
Experience leaves a trace in the nervous system through plasticity. However, the exact meaning of the mnesic trace is poorly defined in current literature. This article provides a historical review of the term trace in neuroscience and psychoanalysis literature, to highlight two relevant aspects: the diachronic and the semantic dimensions. There has been a general interest in diachrony, or a form of evolution of the trace, but its indissociable semantic dimension remains partially disregarded. Although frequently implied, the diachronic and semantic dimensions of the trace are rarely clearly articulated...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28690447/the-missing-manuscript-of-dr-jose-delgado-s-radio-controlled-bulls
#11
REVIEW
Timothy C Marzullo
Neuroscience systems level courses teach: 1) the role of neuroanatomical structures of the brain for perception, movement, and cognition; 2) methods to manipulate and study the brain including lesions, electrophysiological recordings, microstimulation, optogenetics, and pharmacology; 3) proper interpretation of behavioral data to deduce brain circuit operation; and 4) the similarities, differences, and ethics of animal models and their relation to human physiology. These four topics come together quite dramatically in Dr...
2017: Journal of Undergraduate Neuroscience Education: JUNE: a Publication of FUN, Faculty for Undergraduate Neuroscience
https://www.readbyqxmd.com/read/28690441/drugs-the-brain-case-based-instruction-for-an-undergraduate-neuropharmacology-course
#12
Anastasia Nagel, Andrea Nicholas
In order to transform a traditional large non-majors general education (GE) neurobiology lecture (Drugs & the Brain) into an active learning course, we developed a series of directed mini-cases targeting major drug classes. Humorous and captivating case-based situations were used to better engage and motivate students to solve problems related to neuropharmacology and physiology. Here we provide directed cases, questions and learning outcomes for our opiates mini-cases. In addition, we describe how case studies were incorporated into our course and assessed using peer review and online quizzing...
2017: Journal of Undergraduate Neuroscience Education: JUNE: a Publication of FUN, Faculty for Undergraduate Neuroscience
https://www.readbyqxmd.com/read/28690434/don-t-believe-the-gripe-increasing-course-structure-in-a-large-non-majors-neuroscience-course
#13
Anastasia Nagel, Andrea Nicholas
Active teaching is increasingly accepted as a better option for higher education STEM courses than traditional lecture-based instruction. However, concerns remain regarding student preferences and the impact of increased course structure on teaching evaluations. Undergraduates in a non-majors neuropharmacology course were enrolled in an enriched blended course format, providing online case-based learning opportunities in a large lecture hall setting. Students working in small assigned groups solved weekly case studies developed to teach basic neuropharmacology concepts...
2017: Journal of Undergraduate Neuroscience Education: JUNE: a Publication of FUN, Faculty for Undergraduate Neuroscience
https://www.readbyqxmd.com/read/28688701/basic-and-functional-effects-of-transcranial-electrical-stimulation-tes-an-introduction
#14
REVIEW
Fatemeh Yavari, Asif Jamil, Mohsen Mosayebi Samani, Liliane Pinto Vidor, Michael A Nitsche
Non-invasive brain stimulation (NIBS) has been gaining increased popularity in human neuroscience research during the last years. Among the emerging NIBS tools is transcranial electrical stimulation (tES), whose main modalities are transcranial direct, and alternating current stimulation (tDCS, tACS). In tES, a small current (usually less than 3mA) is delivered through the scalp. Depending on its shape, density, and duration, the applied current induces acute or long-lasting effects on excitability and activity of cerebral regions, and brain networks...
July 5, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28687519/laminar-fmri-applications-for-cognitive-neuroscience
#15
REVIEW
Samuel J D Lawrence, Elia Formisano, Lars Muckli, Floris P de Lange
The cortex is a massively recurrent network, characterized by feedforward and feedback connections between brain areas as well as lateral connections within an area. Feedforward, horizontal and feedback responses largely activate separate layers of a cortical unit, meaning they can be dissociated by lamina-resolved neurophysiological techniques. Such techniques are invasive and are therefore rarely used in humans. However, recent developments in high spatial resolution fMRI allow for non-invasive, in vivo measurements of brain responses specific to separate cortical layers...
July 4, 2017: NeuroImage
https://www.readbyqxmd.com/read/28684334/just-a-thought-how-mind-wandering-is-represented-in-dynamic-brain-connectivity
#16
REVIEW
Aaron Kucyi
The neuroscience of mind-wandering has begun to flourish, with roles of brain regions and networks being defined for various components of spontaneous thought. However, often underappreciated is that most of brain activity does not represent immediately occurring thoughts. Instead, spontaneous, organized network activity largely reflects "intrinsic" functions that are unrelated to the current experience. There remains no consensus on how brain networks represent mind-wandering in parallel to functioning in other ongoing, predominantly unconscious processes...
July 3, 2017: NeuroImage
https://www.readbyqxmd.com/read/28675555/rna-sequencing-in-postmortem-human-brains-of-neuropsychiatric-disorders
#17
Chun Wu, Raphael M Bendriem, Susanna P Garamszegi, Lei Song, Chun-Ting Lee
RNA sequencing (RNA-Seq), a revolutionary tool for transcriptome profiling, is becoming increasingly important for neuroscientists in studying the transcriptional landscape of the human brain. Studies using this next generation sequencing (NGS) technique have already revealed novel insights into the complexity of neurons in the human brain and pathogenesis of complex neurological diseases. In clinical neuroscience, RNA-Seq provides exciting opportunities for improving diagnosis and treatment of neurological diseases by facilitating the development of pharmacotherapies able to modulate gene expression...
July 4, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28669605/industrial-medicinal-chemistry-insights-neuroscience-hit-generation-at-janssen
#18
REVIEW
Gary Tresadern, Frederik J R Rombouts, Daniel Oehlrich, Gregor Macdonald, Andres A Trabanco
The role of medicinal chemistry has changed over the past 10 years. Chemistry had become one step in a process; funneling the output of high-throughput screening (HTS) on to the next stage. The goal to identify the ideal clinical compound remains, but the means to achieve this have changed. Modern medicinal chemistry is responsible for integrating innovation throughout early drug discovery, including new screening paradigms, computational approaches, novel synthetic chemistry, gene-family screening, investigating routes of delivery, and so on...
June 29, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/28668576/functional-outcomes-following-lesions-in-visual-cortex-implications-for-plasticity-of-high-level-vision
#19
Tina T Liu, Marlene Behrmann
Understanding the nature and extent of neural plasticity in humans remains a key challenge for neuroscience. Importantly, however, a precise characterization of plasticity and its underlying mechanism has the potential to enable new approaches for enhancing reorganization of cortical function. Investigations of the impairment and subsequent recovery of cognitive and perceptual functions following early-onset cortical lesions in humans provide a unique opportunity to elucidate how the brain changes, adapts, and reorganizes...
June 28, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28668365/recurrent-neural-networks-as-versatile-tools-of-neuroscience-research
#20
REVIEW
Omri Barak
Recurrent neural networks (RNNs) are a class of computational models that are often used as a tool to explain neurobiological phenomena, considering anatomical, electrophysiological and computational constraints. RNNs can either be designed to implement a certain dynamical principle, or they can be trained by input-output examples. Recently, there has been large progress in utilizing trained RNNs both for computational tasks, and as explanations of neural phenomena. I will review how combining trained RNNs with reverse engineering can provide an alternative framework for modeling in neuroscience, potentially serving as a powerful hypothesis generation tool...
June 29, 2017: Current Opinion in Neurobiology
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