Ignacio Valenzuela-Chavira, David O Corona-Martinez, Karina D Garcia-Orozco, Melissa Beltran-Torres, Filiberto Sanchez-Lopez, Aldo A Arvizu-Flores, Rocio Sugich-Miranda, Alonso A Lopez-Zavala, Ramon E Robles-Zepeda, Maria A Islas-Osuna, Adrian Ochoa-Leyva, Michael D Toney, Hugo Serrano-Posada, Rogerio R Sotelo-Mundo
Glutathione S-transferases are a family of detoxifying enzymes that catalyze the conjugation of reduced glutathione (GSH) with different xenobiotic compounds using either Ser, Tyr, or Cys as a primary catalytic residue. We identified a novel GST in the genome of the shrimp pathogen V. parahaemolyticus FIM- S1708+ , a bacterial strain associated with Acute Hepatopancreatic Necrosis Disease (AHPND)/Early Mortality Syndrome (EMS) in cultured shrimp. This new GST class was named Gtt2. It has an atypical catalytic mechanism in which a water molecule instead of Ser, Tyr, or Cys activates the sulfhydryl group of GSH...
September 17, 2021: Toxins