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https://www.readbyqxmd.com/read/29628359/gene-expression-phenotype-associations-in-adults-with-eosinophilic-esophagitis
#1
Evan S Dellon, Sara R Selitsky, Robert M Genta, Richard H Lash, Joel S Parker
BACKGROUND: Gene expression patterns have not been extensively examined in the context of clinical features of eosinophilic esophagitis (EoE). AIMS: To assess whether gene expression is associated with clinically defined phenotypes in adults with EoE. METHODS: This was an analysis of prospectively collected esophageal biopsies in newly diagnosed EoE patients. We determined differential gene expression with a 94 gene panel in relation to clinical features and phenotypes...
March 27, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29626424/multifocal-nitrous-oxide-cryoballoon-ablation-with-or-without-emr-for-treatment-of-neoplastic-barrett-s-esophagus
#2
Marcia Irene Canto, Nicholas J Shaheen, Jose Alejandro Almario, Lysandra Voltaggio, Elizabeth Montgomery, Charles J Lightdale
BACKGROUND AND AIMS: Endoscopic cryotherapy can eradicate neoplastic Barrett's esophagus (BE). A new contact cryoballoon focal ablation system (CbFAS)) freezes esophageal mucosa with nitrous oxide. We studied the safety and efficacy of CbFAS for complete eradication of neoplastic Barrett's esophagus. METHODS: In a prospective clinical trial, consecutive BE patients with confirmed neoplasia (low-grade dysplasia LGD, high-grade dysplasia HGD, and/or intramucosal adenocarcinoma ImCA), at least 1 cm of BE, with or without prior ablation, were treated with a dose 10 seconds of spray per site...
April 4, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29620969/clinical-analysis-of-endoscopic-submucosal-dissection-for-the-synchronous-multiple-primary-early-cancers-in-esophagus-and-stomach-12-cases-report
#3
Qiang Shi, Di Sun, Shi-Lun Cai, Mei-Dong Xu, Zhi-Peng Qi, Bing Li, Li-Qing Yao, Yun-Shi Zhong, Ping-Hong Zhou
OBJECTIVE: With the improvement of endoscopic diagnosis, the discovery rate of the synchronous multiple primary early cancers in esophagus and stomach is gradually increased, while the traditional surgery bringing serious damages. Endoscopic submucosal dissection (ESD) has become the first treatment option of early cancer in the digestive tract partly. This study intends to explore the feasibility, safety, and effectiveness of ESD in the treatment of the synchronous multiple early gastric cancer or precancerous lesions in the esophagus and stomach...
April 5, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29619511/results-of-magnetic-sphincter-augmentation-for-gastroesophageal-reflux-disease
#4
Katrin Schwameis, Milena Nikolic, Deivis G Morales Castellano, Ariane Steindl, Sarah Macheck, Ivan Kristo, Barbara Zörner, Sebastian F Schoppmann
BACKGROUND: Magnetic sphincter augmentation (MSA) is a modern treatment option for gastroesophageal reflux disease (GERD); however, laparoscopic fundoplication remains the gold standard. The aim of the study was to evaluate outcomes of MSA patients at a reflux center. METHODS: A retrospective review was performed of all patients that underwent MSA between March 2012 and November 2017. Out of 110 patients, 68 with a follow-up >3 months were included. Postoperative gastrointestinal symptoms, proton pump inhibitor (PPI) intake, GERD-Health-related Quality of Life (GERD-HRQL) and alimentary satisfaction (AS) were assessed...
April 4, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29608597/a-clinical-study-of-peroral-endoscopic-myotomy-reveals-that-impaired-lower-esophageal-sphincter-relaxation-in-achalasia-is-not-only-defined-by-high-resolution-manometry
#5
Hiroki Sato, Kazuya Takahashi, Ken-Ichi Mizuno, Satoru Hashimoto, Junji Yokoyama, Shuji Terai
BACKGROUND AND AIM: Achalasia is an esophageal motility disorder characterized by impaired lower esophageal sphincter (LES) relaxation. On high-resolution manometry (HRM), impaired LES relaxation is defined by elevated integrated relaxation pressure (IRP). However, a new category of achalasia within the normal IRP range has been suggested. METHODS: HRM was performed using a Starlet device and an IRP threshold of 26 mmHg. Peroral endoscopic myotomy (POEM) was performed for cases of achalasia diagnosed using established methods...
2018: PloS One
https://www.readbyqxmd.com/read/29605775/a-thoracoabdominal-approach-for-gastrobronchial-fistula-repair-post-complicated-laparoscopic-sleeve-gastrectomy
#6
Abdullah Alshammari, Sreyoshi Fatima Alam, Mohammed Hussein Ahmed, Khaled AlKattan
INTRODUCTION: There has been a recent surge in bariatric surgery. Consequently, identification of new complications is imminent. Gastrobronchial fistula is one of the newly identified severe complications. The medical community is yet to come up with a consensus on management, which is further complicated by the lack of literature on par with its rarity. Therefore, we aim to contribute to a better understanding and add to the managerial approach. PRESENTATION OF CASE: We report a case of a 36-year-old female...
March 26, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29602985/rendezvous-endoscopic-recanalization-for-complete-esophageal-obstruction
#7
Stefano Fusco, Thomas Kratt, Cihan Gani, Dietmar Stueker, Daniel Zips, Nisar P Malek, Martin Goetz
BACKGROUND AND STUDY AIM: Complete esophageal obstruction after (chemo)radiation for head and neck cancers is rare. However, inability to swallow one's own saliva strongly inflicts upon quality of life. Techniques for endoscopic recanalization in complete obstruction are not well established. We assessed the efficacy and safety of rendezvous recanalization. PATIENTS AND METHODS: We performed a retrospective review of all patients who underwent endoscopic recanalization of complete proximal esophageal obstruction after radiotherapy between January 2009 and June 2016...
March 30, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29560669/ectopic-variceal-bleeding-due-to-portosystemic-shunt-via-dilated-mesenteric-veins-and-a-varicous-left-ovarian-vein-case-report-and-literature-review-of-ectopic-varices
#8
REVIEW
Mathieu Struyve, Geert Robaeys
Ectopic varices are dilated portosystemic venous collaterals located outside of the gastro-esophageal region. Whereas they are common endoscopic findings in patients with portal hypertension, ectopic variceal bleeding is rather rare and accounts for only 1 to 5 % of all variceal bleedings. The rectum and the duodenum are the most common sites for ectopic varices, but they can be present along the whole intestinal tract and neighborhood. At present, there is no consensus well established on diagnostic workup for ectopic variceal bleeding and their therapeutic strategies...
July 2017: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/29557595/complications-during-esophageal-endoscopy-with-or-without-baloon-dilation-under-general-anesthesia-in-pediatric-patients-a-prospective-and-observational-study
#9
Pinar Kendigelen, Ayse C Tutuncu, Senol Emre, Fatis Altindas, Guner Kaya
BACKGROUND: Complications can occur during esophagoscopy as a result of applied procedure in children, especially during dilation techic. Our aim was to identify cardio-respiratory alterations during esophagoscopy with or without baloon dilation under anesthesia in children, and to investigate the postoperative complications. METHODS: Prospective, observational study of endoscopic procedures in patients 0-16 years. The patients were divided into two groups: the endoscopy-dilation group (Group ED: endoscopy and balloon dilation due to esophageal stricture) and endoscopy without dilation (Group E: endoscopy for diagnostic reasons, control esophagoscopy or sclerotherapy)...
April 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29557070/esophageal-stenting-in-clinical-practice-an-overview
#10
REVIEW
Bram D Vermeulen, Peter D Siersema
OPINION STATEMENT: PURPOSE OF REVIEW: Esophageal stents are used in clinical practice for endoscopic treatment of a wide variety of esophageal diseases and conditions. This review provides key principles and a literature update on the utility and limitations of esophageal stenting in clinical practice. RECENT FINDINGS: Indications for esophageal stenting can be subdivided into two groups. The first group consists of patients with malignant or benign dysphagia, in which an esophageal stent restores luminal patency...
March 19, 2018: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/29531468/effect-of-polyglycolic-acid-sheet-plus-esophageal-stent-placement-in-preventing-esophageal-stricture-after-endoscopic-submucosal-dissection-in-patients-with-early-stage-esophageal-cancer-a-randomized-controlled-trial
#11
Ning-Li Chai, Jia Feng, Long-Song Li, Sheng-Zhen Liu, Chen Du, Qi Zhang, En-Qiang Linghu
AIM: To assess the effect of polyglycolic acid (PGA) plus stent placement compared with stent placement alone in the prevention of post-endoscopic submucosal dissection (ESD) esophageal stricture in early-stage esophageal cancer (EC) patients. METHODS: Seventy EC patients undergoing ESD were enrolled in this randomized, controlled study. Patients were allocated randomly at a 1:1 ratio into two groups as follows: (1) PGA plus stent group (PGA sheet-coated stent placement was performed); and (2) Stent group (only stent placement was performed)...
March 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29527557/endoscopic-submucosal-dissection-to-relieve-a-flexure-of-the-gastric-conduit-after-esophagectomy
#12
Katsumi Yamamoto, Hiroshi Noro, Yu Sato, Akira Kusakabe, Nobuyuki Tatsumi, Tomoki Michida, Toshifumi Ito
Background and study aims  A 70-year-old-man underwent an esophagectomy and posterior mediastinal reconstruction for esophageal cancer that was curatively resected. Although the patient was allowed to eat after surgery, he repeatedly vomited after drinking water or eating meals and required continuous hospitalization. An upper gastrointestinal series and endoscopic examination revealed an obstruction due to the flexure of the gastric conduit, which was repeatedly treated with endoscopic balloon dilation. Endoscopic balloon dilation was completely ineffective, however, because the obstruction was not due to a small lumen diameter, but rather to severe flexure...
March 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/29516959/clinical-efficacy-of-endoscopic-submucosal-dissection-in-the-treatment-of-early-esophageal-cancer-and-precancerous-lesions
#13
Yue Wu, Haihui Zhang, Bingxi Zhou, Shuangyin Han, Yanrui Zhang
Objective: The objective of this study was to evaluate the clinical value of endoscopic submucosal dissection (ESD) in the treatment of early esophageal cancer and precancerous lesions. Materials and Methods: We retrospectively analyzed 58 patients who suffered from early esophageal and precancerous lesions and received ESD in the First Affiliated Hospital of Zhengzhou University from February 2012 to January 2016. The clinical efficacy and safety of ESD in treating the early esophageal cancer and precancerous lesions was evaluated by analyzing the operation successful rate, postoperative pathology, complications, and follow-up data of patients who received ESD...
January 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29513174/ectopic-variceal-bleeding-due-to-portosystemic-shunt-via-dilated-mesenteric-veins-and-a-varicous-left-ovarian-vein-case-report-and-literature-review-of-ectopic-varices
#14
M Struyve, G Robaeys
Ectopic varices are dilated portosystemic venous collaterals located outside of the gastro-esophageal region. Whereas they are common endoscopic findings in patients with portal hypertension, ectopic variceal bleeding is rather rare and accounts for only 1 to 5 % of all variceal bleedings. The rectum and the duodenum are the most common sites for ectopic varices, but they can be present along the whole intestinal tract and neighborhood. At present, there is no consensus well established on diagnostic workup for ectopic variceal bleeding and their therapeutic strategies...
July 2017: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/29509537/endoscopic-treatment-of-benign-esophageal-fistulas-using-fully-covered-metallic-esophageal-stents
#15
Denisa Oprisanescu, Denisa Bucur, Vasile Sandru, Ioan Cristian Nedelcu, Madalina Ilie, Ruxandra Oprita, Gabriel Constantinescu
Non-malignant esophageal fistulas have a wide spectrum of clinical and pathological features and it`s important to learn to detect and treat them, due to significant morbidity, mortality and costs. The need for minimally invasive, efficient and also quick procedures is imperative. Esophageal stenting using fully-covered expandable stents has become an increasingly preferred option and addresses to fistulas which arise from 2-3 cm beyond Killian's mouth and up to the gastroesophageal junction. The long-term purpose of the procedure is closure of the fistula and thus healing...
January 2018: Chirurgia
https://www.readbyqxmd.com/read/29509532/high-resolution-manometry-a-mandatory-examination-in-the-pre-and-postoperative-assessment-of-patients-with-achalasia
#16
Anca Dimitriu, Cristian Gheorghe
High resolution manometry (HRM) is currently the gold standard for the diagnosis of achalasia and other functional esophageal disorders. All patients accusing dysphagia should be endoscopically evaluated prior to manometric investigations in order to rule out pseudoachalasia. The Chicago HRM classification has led to a subclassification of three manometric types of achalasia that seem to have different results to treatment. None of the actual achalasia treatment options are curative. Type II achalasia patients respond best to all treatment options compared to those with types I and III...
January 2018: Chirurgia
https://www.readbyqxmd.com/read/29471155/early-results-of-magnetic-sphincter-augmentation-versus-fundoplication-for-gastroesophageal-reflux-disease-systematic-review-and-meta-analysis
#17
REVIEW
Alberto Aiolfi, Emanuele Asti, Daniele Bernardi, Gianluca Bonitta, Emanuele Rausa, Stefano Siboni, Luigi Bonavina
BACKGROUND: Laparoscopic Nissen and Toupet fundoplication (LF) are currently considered gold-standard surgical treatment for Gastroesophageal Reflux Disease (GERD). Magnetic Sphincter Augmentation (MSA) is an innovative surgical procedure that has been showed to be effective to control GERD symptoms and to reduce esophageal acid exposure. The aim of this systematic review and meta-analysis was to compare early outcomes of LF and MSA. MATERIALS AND METHODS: PubMed, MEDLINE, Embase, and Cochrane databases were consulted matching the terms "Gastroesophageal reflux or heartburn", "LINX or magnetic sphincter augmentation" and "fundoplication"...
February 20, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29467556/predictors-of-post-treatment-stenosis-in-cervical-esophageal-cancer-undergoing-high-dose-radiotherapy
#18
Jun Won Kim, Tae Hyung Kim, Jie-Hyun Kim, Ik Jae Lee
AIM: To evaluate toxicity and treatment outcome of high-dose radiotherapy (RT) for cervical esophageal cancer (CEC). METHODS: We reviewed a total of 62 consecutive patients who received definitive RT for stage I to III cervical esophageal cancer between 2001 and 2015. Patients who received < 45 Gy, treated for lesions below sternal notch, treated with palliative aim, treated with subsequent surgical resection, or diagnosed with synchronous hypopharyngeal cancer were excluded...
February 21, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29460330/prospective-evaluation-of-an-indwelling-esophageal-balloon-dilatation-feeding-tube-for-treatment-of-benign-esophageal-strictures-in-dogs-and-cats
#19
Desmond K Tan, Chick Weisse, Allyson Berent, Kenneth E Lamb
BACKGROUND: Despite multiple dilatation procedures, benign esophageal strictures (BES) remain a recurring cause of morbidity and mortality in dogs and cats. OBJECTIVE: Investigate the use of an indwelling Balloon Dilatation esophagostomy tube (B-Tube) for treatment of BES in dogs and cats. ANIMALS: Nine dogs and 3 cats. METHODS: Animals with BES were recruited for our prospective study. Endoscopic and fluoroscopic evaluation of the esophagus and balloon dilatation were performed under general anesthesia, followed by placement of an indwelling B-Tube...
February 20, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29451522/-management-of-benign-esophageal-strictures-a-literature-review
#20
Leonardo Frazzoni, Marina La Marca, Amedeo Montale, Lorenzo Fuccio
The management of benign esophageal strictures is challenging. The first strategy includes endoscopic dilation using bougies or balloons. Although the immediate success rate of these is up to 90%, about 30-40% of patients experience recurrent dysphagia within the first year of follow-up. The management of refractory stenosis involves repeated sessions of endoscopic dilation. In order to obtain long-lasting functional results, alternative treatments have been developed, such as the use of self-expanding stents, particularly indicated in subgroups of patients with post-surgical stenosis or post-radiation therapy...
January 2018: Recenti Progressi in Medicina
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