Natalia A Shnayder, Violetta V Grechkina, Aiperi K Khasanova, Elena N Bochanova, Evgenia A Dontceva, Marina M Petrova, Azat R Asadullin, German A Shipulin, Kuanysh S Altynbekov, Mustafa Al-Zamil, Regina F Nasyrova
Valproic acid (VPA) and its salts are psychotropic drugs that are widely used in neurological diseases (epilepsy, neuropathic pain, migraine, etc.) and psychiatric disorders (schizophrenia, bipolar affective disorder, addiction diseases, etc.). In addition, the indications for the appointment of valproate have been expanding in recent years in connection with the study of new mechanisms of action of therapeutic and toxic metabolites of VPA in the human body. Thus, VPA is considered a component of disease-modifying therapy for multiple tumors, neurodegenerative diseases (Huntington's disease, Parkinson's disease, Duchenne progressive dystrophy, etc...
January 16, 2023: Metabolites