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https://www.readbyqxmd.com/read/29332930/bullosis-diabeticorum-a-rare-presentation-with-immunoglobulin-g-igg-deposition-related-vasculopathy-case-report-and-focused-review
#1
Hardik Sonani, Sohail Abdul Salim, Vishnu V Garla, Anna Wile, Venkataraman Palabindala
BACKGROUND Bullosis diabeticorum (BD) is a condition characterized by recurrent, spontaneous, and non-inflammatory blistering in patients with poorly controlled diabetes mellitus. While etiopathogenesis remains unclear, roles of neuropathy, vasculopathy and UV light are hypothesized. Most literature reports negative direct and indirect immunofluorescence findings in diabetics with bullous eruptions. Porphyria cutanea tarda, bullous pemphigoid, epidermolysis bullosa, and pseudoporphyria are other differential diagnoses of bullous lesions, and they must be excluded...
January 15, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29329980/a-mass-spectrometry-imaging-approach-for-investigating-how-drug-drug-interactions-influence-drug-blood-brain-barrier-permeability
#2
Theodosia Vallianatou, Nicole Strittmatter, Anna Nilsson, Mohammadreza Shariatgorji, Gregory Hamm, Marcela Pereira, Patrik Källback, Per Svenningsson, Maria Karlgren, Richard J A Goodwin, Per E Andrén
There is a high need to develop quantitative imaging methods capable of providing detailed brain localization information of several molecular species simultaneously. In addition, extensive information on the effect of the blood-brain barrier on the penetration, distribution and efficacy of neuroactive compounds is required. Thus, we have developed a mass spectrometry imaging method to visualize and quantify the brain distribution of drugs with varying blood-brain barrier permeability. With this approach, we were able to determine blood-brain barrier transport of different drugs and define the drug distribution in very small brain structures (e...
January 9, 2018: NeuroImage
https://www.readbyqxmd.com/read/29327223/one-bone-forearm-osteodesis-and-biceps-re-routing-to-correct-severe-supination-contracture-in%C3%A2-a-paediatric-patient-with-late-obstetric-brachial-plexus-palsy
#3
Ricardo Monreal
PURPOSE: The one-bone forearm arthrodesis has been performed to change the position of the forearm in children with fixed supination deformity due to upper extremity neurologic deficit. In this article, we present a retrospective review of children with late obstetric brachial plexus palsy who underwent palliative surgery to correct severe supination contracture by one-bone forearm osteodesis and biceps re-routing. This technique has not been described previously. MATERIALS AND METHODS: In this retrospective study, four consecutive patients with upper extremity weakness and severe supination contracture who underwent forearm osteodesis in neutral or slight pronation and biceps re-routing...
January 12, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29325942/perineural-spread-of-melanoma-to-the-brachial-plexus-identifying-the-anatomic-pathway-s
#4
Tomas Marek, Ruple S Laughlin, B Matthew Howe, Robert J Spinner
BACKGROUND: Perineural spread of melanoma is a well-known mechanism of metastasis in cases involving cranial nerves. Brachial plexus involvement is rare and the pathway is unknown. METHODS: A retrospective review of the Mayo Clinic database was performed to identify patients with a history of melanoma and brachial plexus compromise between 1994 and 2017. Inclusion criteria were a history of melanoma, a clinical diagnosis of brachial plexopathy, radiological features consistent with perineural spread and biopsy of melanoma within nerve...
January 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29325337/-the-application-of-combining-low-dose-naloxone-with-ropivacaine-in-supraclavicular-brachial-plexus-block
#5
J Tang, S Y Zhang, F J Lu, W H Qin, Y S Shi
Objective: To observe the effect of low dose naloxone combinewith ropivacaine for supraclavicular brachial plexus block. Methods: Seventy patients undergoing elective upper limb surgery were randomly divided into two groups, ropivacaine group (Group R, n=35) and naloxone group (Group N, n=35). An ultrasound guided technique was used in both two groups.The onset and duration time of sensory and motor blockade, visual analog score(VAS)of 3, 6, 12, 18, 24 h postoperatively, time of first request fordezocine, total amount of dezocine needed, incidence of nausea and vomiting postoperatively(PONV) and patients' satisfaction score for analgesia in 24 h after surgery were measured...
December 26, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29323028/surgical-reconstruction-of-spinal-cord-circuit-provides-functional-return-in-humans
#6
REVIEW
Thomas Carlstedt, Nicholas James, Mårten Risling
This mini review describes the current surgical strategy for restoring function after traumatic spinal nerve root avulsion in brachial or lumbosacral plexus injury in man. As this lesion is a spinal cord or central nervous injury functional return depends on spinal cord nerve cell growth within the central nervous system. Basic science, clinical research and human application has demonstrated good and useful motor function after ventral root avulsion followed by spinal cord reimplantation. Recently, sensory return could be demonstrated following spinal cord surgery bypassing the injured primary sensory neuron...
December 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/29322233/high-isotropic-resolution-t2-mapping-of-the-lumbosacral-plexus-with-t2-prepared-3d-turbo-spin-echo
#7
Nico Sollmann, Dominik Weidlich, Barbara Cervantes, Elisabeth Klupp, Carl Ganter, Hendrik Kooijman, Ernst J Rummeny, Claus Zimmer, Jan S Kirschke, Dimitrios C Karampinos
PURPOSE: Isotropic high-resolution three-dimensional (3D) magnetic resonance neurography (MRN) is increasingly used to depict even small and highly oblique nerves of the lumbosacral plexus (LSP). The present study introduces a T2 mapping sequence (T2-prepared 3D turbo spin echo) that is B1-insensitive and enables quantitative assessment of LSP nerves. METHODS: In this study 15 healthy subjects (mean age 28.5 ± 3.8 years) underwent 3 T MRN of the LSP area three times...
January 10, 2018: Clinical Neuroradiology
https://www.readbyqxmd.com/read/29320777/a-case-of-giant-supratentorial-choroid-plexus-carcinoma-in-a-young-girl
#8
Saumya Gupta, Kirti Gupta, Apinderpreet Singh
No abstract text is available yet for this article.
January 11, 2018: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29318427/mr-neurography-in-traumatic-non-obstetric-paediatric-brachial-plexopathy
#9
Vaishali Upadhyaya, Divya Narain Upadhyaya, Brijesh Mishra
OBJECTIVES: Many studies have elaborated on the role of magnetic resonance neurography (MRN) in evaluating traumatic brachial plexopathies. Most of these deal with MR findings in adult traumatic plexopathies or children with obstetric brachial plexus palsy (OBPP). Hence, the authors felt the need for this particular study, which focuses on MRN findings in children with non-obstetric traumatic brachial plexus palsy, to find out the distribution and severity of injuries in these patients...
January 9, 2018: European Radiology
https://www.readbyqxmd.com/read/29318367/-vascular-anomalies-part%C3%A2-ii-vascular-malformations
#10
S Mylonas, S Brunkwall, J Brunkwall
Vascular malformations are congenital vascular anomalies with normal endothelial turnover, which can affect the whole vessel tree (arterial, capillary or lymphatic) both as isolated defects or as part of a syndrome. Developmental errors during embryogenesis, such as abnormal signaling processes that control the apoptosis, maturation and growth of vascular cells, lead to the persistence of vascular plexus cells with some degree of differentiation. Vascular malformations are usually present at birth, although symptoms or complications may be manifested later...
January 9, 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29317443/a-mutation-in-ccdc39-causes-neonatal-hydrocephalus-with-abnormal-motile-cilia-development-in-mice
#11
Zakia Abdelhamed, Shawn M Vuong, Lauren Hill, Crystal Shula, Andrew Timms, David Beier, Kenneth Campbell, Francesco T Mangano, Rolf W Stottmann, June Goto
Pediatric hydrocephalus is characterized by an abnormal accumulation of cerebrospinal fluid (CSF) and is one of the most common congenital brain abnormalities. However, little is known about the molecular and cellular mechanisms regulating CSF flow in the developing brain. Through whole-genome sequencing analysis, we report that a homozygous splice site mutation in coiled-coil domain containing 39 (Ccdc39) is responsible for early postnatal hydrocephalus in the progressive hydrocephalus (prh) mouse mutant. Ccdc39 is selectively expressed in embryonic choroid plexus and ependymal cells on the medial wall of the forebrain ventricle, and the protein is localized to the axoneme of motile cilia...
January 9, 2018: Development
https://www.readbyqxmd.com/read/29317073/micro-calibration-of-space-and-motion-by-photoreceptors-synchronized-in-parallel-with-cortical-oscillations-a-unified-theory-of-visual-perception
#12
Ravinder Jerath, Shannon M Cearley, Vernon A Barnes, Mike Jensen
A fundamental function of the visual system is detecting motion, yet visual perception is poorly understood. Current research has determined that the retina and ganglion cells elicit responses for motion detection; however, the underlying mechanism for this is incompletely understood. Previously we proposed that retinogeniculo-cortical oscillations and photoreceptors work in parallel to process vision. Here we propose that motion could also be processed within the retina, and not in the brain as current theory suggests...
January 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29316719/calbindin-d28k-immunoreactivity-in-human-enteric-neurons
#13
Katharina Zetzmann, Johanna Strehl, Carol Geppert, Stefanie Kuerten, Samir Jabari, Axel Brehmer
Calbindin (CALB) is well established as immunohistochemical marker for intrinsic primary afferent neurons in the guinea pig gut. Its expression by numerous human enteric neurons has been demonstrated but little is known about particular types of neurons immunoreactive for CALB. Here we investigated small and large intestinal wholemount sets of 26 tumor patients in order to evaluate (1) the proportion of CALB⁺ neurons in the total neuron population, (2) the colocalization of CALB with calretinin (CALR), somatostatin (SOM) and vasoactive intestinal peptide (VIP) and (3) the morphology of CALB+ neurons...
January 8, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29311586/the-corneal-subbasal-nerve-plexus-and-thickness-of-the-retinal-layers-in-pediatric-type-1-diabetes-and-matched-controls
#14
Aline Götze, Sophie von Keyserlingk, Sabine Peschel, Ulrike Jacoby, Corinna Schreiver, Bernd Köhler, Stephan Allgeier, Karsten Winter, Martin Röhlig, Anselm Jünemann, Rainer Guthoff, Oliver Stachs, Dagmar-C Fischer
Optical coherence tomography (OCT) of the retina and corneal confocal laser scanning microscopy (CLSM) of the subbasal nerve plexus (SBP) are noninvasive techniques for quantification of the ocular neurodegenerative changes in individuals with type 1 diabetes mellitus (T1DM). In adult T1DM patients these changes are hardly related to T1DM only. Instead, ageing and/or lifestyle associated comorbidities have to be considered as putative confounding variables. Therefore, we investigated pediatric T1DM patients (n = 28; 14...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29310336/removal-of-a-subdermal-contraceptive-implant-implanon-nxt-that-migrated-to-the-axilla-by-c-arm-guidance-a-case-report-and-review-of-the-literature
#15
Ji Ung Park, Han Sol Bae, Seung Mi Lee, Jaehoon Bae, Jeong Woo Park
RATIONALE: To report the distant migration of a subdermal contraceptive implant and to suggest that C arm-guided technique is one of the feasible options for removal of the device migrated to the axilla. PATIENT CONCERNS: A 41-year-old multipara with tingling sensation in the left axilla was referred for removal of an Implanon NXT which could not be palpated by physical examination or detected by ultrasound scanning. Finally, the device was detected by computed tomography and found migrating to the left axilla...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29305362/axillary-artery-aneurysm-combined-with-brachial-plexus-palsy-due-to-takayasu-arteritis
#16
Denise Kim, Graham Roche-Nagle
We report the case of a young female patient who presented with a right axillary artery aneurysm with neurological symptoms due to Takayasuarteritis (TA). Decompression of the aneurysm and arterial repair with an interposition vein bypass resulted in a full recovery. The case emphasises that peripheral aneurysms can occur due to TA and that there may be neurological complications.
January 5, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29305268/long-term-estradiol-17%C3%AE-exposure-decreases-the-cholinergic-innervation-pattern-of-the-pig-ovary
#17
B Jana, K A Meller, M Czajkowska, J Całka
Elevated levels of endogenous estrogens in the course of pathological states of ovaries, as well as xenoestrogens, may lead to hyperestrogenism. It has previously been demonstrated that long-term estradiol-17β (E2) administration in adult gilts affected the population of sympathetic intraovarian nerve fibers. The aim of this study has been to determine the effect of long-term E2 exposure on the cholinergic innervation pattern of porcine ovaries. Intraovarian distribution and the density of nerve fibers immunoreactive (IR) to vesicular acetylocholine transporter (VAChT) and/or neuronal isoform of nitric oxide synthase (nNOS), vasoactive intestinal polypeptide (VIP), somatostatin (SOM) were determined...
January 2, 2018: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/29305235/validation-of-isometric-tetanic-force-as-a-measure-of-muscle-recovery-after-nerve-injury-in-the-rabbit-biceps
#18
Kathleen M Kollitz, Guilherme Giusti, Patricia F Friedrich, Allen T Bishop, Alexander Y Shin
PURPOSE: The purpose of this study was to describe and validate a technique for measurement of isometric tetanic force (ITF) in the rabbit biceps muscle. MATERIALS AND METHODS: Eighteen New Zealand White rabbits were randomized to test either the right side or the left side first. Under propofol anesthesia, the brachial plexus and biceps brachii were exposed. The middle trunk (C6, C7) was secured in a bipolar electrode. Compound muscle action potential (CMAP) was measured...
January 3, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29305058/altered-gastrointestinal-motility-in-an-animal-model-of-lesch-nyhan-disease
#19
Maria G Zizzo, Monica Frinchi, Domenico Nuzzo, Hyder A Jinnah, Giuseppa Mudò, Daniele F Condorelli, Francesco Caciagli, Renata Ciccarelli, Patrizia Di Iorio, Flavia Mulè, Natale Belluardo, Rosa Serio
Mutations in the HGPRT1 gene, which encodes hypoxanthine-guanine phosphoribosyltransferase (HGprt), housekeeping enzyme responsible for recycling purines, lead to Lesch-Nyhan disease (LND). Clinical expression of LND indicates that HGprt deficiency has adverse effects on gastrointestinal motility. Therefore, we aimed to evaluate intestinal motility in HGprt knockout mice (HGprt¯). Spontaneous and neurally evoked mechanical activity was recorded in vitro as changes in isometric tension in circular muscle strips of distal colon...
December 20, 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/29303230/planned-birth-at-or-near-term-for-improving-health-outcomes-for-pregnant-women-with-gestational-diabetes-and-their-infants
#20
REVIEW
Linda M Biesty, Aoife M Egan, Fidelma Dunne, Eugene Dempsey, Pauline Meskell, Valerie Smith, G Meabh Ni Bhuinneain, Declan Devane
BACKGROUND: Gestational diabetes is a type of diabetes that occurs during pregnancy. Women with gestational diabetes are more likely to experience adverse health outcomes such as pre-eclampsia or polyhydramnios (excess amniotic fluid). Their babies are also more likely to have health complications such as macrosomia (birthweight > 4000 g) and being large-for-gestational age (birthweight above the 90th percentile for gestational age). Current clinical guidelines support elective birth, at or near term in women with gestational diabetes to minimise perinatal complications, especially those related to macrosomia...
January 5, 2018: Cochrane Database of Systematic Reviews
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