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voltage gated potassium channel

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https://www.readbyqxmd.com/read/28087250/pharmacology-of-cannabinoids-in-the-treatment-of-epilepsy
#1
REVIEW
Tyler E Gaston, Daniel Friedman
The use of cannabis products in the treatment of epilepsy has long been of interest to researchers and clinicians alike; however, until recently very little published data were available to support its use. This article summarizes the available scientific data of pharmacology from human and animal studies on the major cannabinoids which have been of interest in the treatment of epilepsy, including ∆9-tetrahydrocannabinol (∆9-THC), cannabidiol (CBD), ∆9-tetrahydrocannabivarin (∆9-THCV), cannabidivarin (CBDV), and ∆9-tetrahydrocannabinolic acid (Δ9-THCA)...
January 10, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28075010/stimulatory-actions-of-a-novel-thiourea-derivative-on-large-conductance-calcium-activated-potassium-channels
#2
Sheng-Nan Wu, Jyh-Haur Chern, Santai Shen, Hwei-Hisen Chen, Ying-Ting Hsu, Chih-Chin Lee, Ming-Huan Chan, Ming-Chi Lai, Feng-Shiun Shie
AIM: In this study, we examine whether an anti-inflammatory thiourea derivative, compound #326, actions on ion channels. METHODS: The effects of compound #326 on Ca(2+) -activated K(+) channels were evaluated by patch-clamp recordings obtained in cell-attached, inside-out or whole-cell configuration. RESULTS: In pituitary GH3 cells, compound #326 increased the amplitude of Ca(2+) -activated K(+) currents (IK(Ca) ) with an EC50 value of 11...
January 11, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28074656/atomistic-modeling-of-ion-conduction-through-the-voltage-sensing-domain-of-the-shaker-k-ion-channel
#3
Mona L Wood, J Alfredo Freites, Francesco Tombola, Douglas J Tobias
Voltage-sensing domains (VSDs) are modular membrane protein units that sense changes in the membrane electrostatic potential, and through conformational changes, regulate a specific function. The VSDs of voltage-dependent K+, Na+, and Ca2+ channels do not conduct ions under physiological conditions, but they can become ion-permeable under pathological conditions through mutations in the voltage sensor, particularly of basic residues (mostly arginines) in the S4 helix. Relatively little is known about the underlying mechanisms of conduction through VSDs...
January 11, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28070819/inducing-polyclonal-eag1-specific-antibodies-by-vaccination-with-a-linear-epitope-immunogen-and-its-relation-to-breast-tumorigenesis
#4
Zhandong Li, Ketong Zhu, Xin Gong, Steven Vasilescu, Yu Sun, Kaiqing Hong, Hao Li, Lin Li, Yaming Shan
Ether à-go-go 1 (KCNH1, Kv10.1) (Eag1) is a voltage-gated potassium channel, which is commonly overexpressed in tested breast cancer patients. This occurrence makes it a potential molecular marker and a promising tool for breast cancer diagnosis and therapy. In order to explore protective or specific polyclonal antibodies for further research, potential linear epitopes from Eag1 were collected by sequence alignment. The sequence was synthesized and then coupled to the carrier protein keyhole limpet hemocyanin (KLH) for animal immunization...
January 9, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28064020/impact-of-geometry-changes-in-the-channel-pore-by-the-gating-movements-on-the-channel-s-conductance
#5
Agata Wawrzkiewicz-Jałowiecka, Przemysław Borys, Zbigniew J Grzywna
Kv 1.2 are voltage-dependent potassium channels of great biological importance. Despite the existence of many reports considering structure - function relations of the Kv 1.2 channel's quantitative domains, some details of the voltage gating remain ambiguous, or even unknown. One of the examples is the range of the S4-S6 domains motions involved in channel activation and gating. Another important question is to what extent the channel geometry influences the observable channel conductance at different voltages, and what mechanism stands behind...
January 4, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28059450/kcnq1-variants-associate-with-hypertension-in-type-2-diabetes-and-affect-smooth-muscle-contractility-in-vitro
#6
Kuo-Chin Huang, Te-Mao Li, Xiang Liu, Jin-Hua Chen, Wen-Kuei Chien, Yi-Tzone Shiao, Hsinyi Tsang, Ting-Hsu Lin, Chiu-Chu Liao, Shao-Mei Huang, Ju-Pi Li, Cheng-Wen Lin, Jung-Chun Lin, Chih-Chien Lin, Chih-Ho Lai, Chi-Fung Cheng, Wen-Miin Liang, Chien-Hui Hung, Ching-Chu Chen, Ying-Ju Lin, Fuu Jen-Tsai
KCNQ1 encodes a potassium voltage-gated channel and represents a susceptibility locus for type 2 diabetes mellitus (T2DM). Here, we explored the association between KCNQ1 polymorphisms and hypertension risk in individuals with T2DM, as well as the role of KCNQ1 in vascular smooth muscle cell contraction in vitro. To investigate the relationship between KCNQ1 and the risk of developing hypertension in patients with T2DM, we divided the T2DM cohort into hypertension (n = 452) and non-hypertension (n = 541) groups...
January 6, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28043063/investigation-of-neuronal-auto-antibodies-in-systemic-lupus-erythematosus-patients-with-epilepsy
#7
Zerrin Karaaslan, Esme Ekizoğlu, Pınar Tektürk, Ece Erdağ, Erdem Tüzün, Nerses Bebek, Candan Gürses, Betül Baykan
PURPOSE: Epilepsy is an important feature for neuropsychiatric involvement in systemic lupus erythematosus (SLE) with unknown mechanism. Our aim was to investigate the presence of neuronal auto-antibodies (NAbs) in neuropsychiatric SLE (NPSLE). METHODS: Eighteen SLE patients (17 females, 1 male) experiencing recurrent seizures were enrolled to this study. Their clinical characteristics, EEG and MRI findings and follow-up information were evaluated from their files...
December 14, 2016: Epilepsy Research
https://www.readbyqxmd.com/read/28042862/hydrogen-sulfide-in-the-adipose-tissue-physiology-pathology-and-a-target-for-pharmacotherapy
#8
REVIEW
Jerzy Bełtowski, Anna Jamroz-Wiśniewska
Hydrogen sulfide (H₂S) is synthesized in the adipose tissue mainly by cystathionine γ-lyase (CSE). Several studies have demonstrated that H₂S is involved in adipogenesis, that is the differentiation of preadipocytes to adipocytes, most likely by inhibiting phosphodiesterases and increasing cyclic AMP concentration. The effect of H₂S on adipose tissue insulin sensitivity and glucose uptake is controversial. Some studies suggest that H₂S inhibits insulin-induced glucose uptake and that excess of H₂S contributes to adipose tissue insulin resistance in metabolic syndrome...
December 31, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28012096/a-sodium-channel-myotonia-presenting-with-intermittent-dysphagia-as-a-manifestation-of-a-rare-scn4a-variant
#9
Jihane N Benhammou, Jennifer Phan, Hane Lee, Kevin Ghassemi, William Parsons, Wayne W Grody, Joseph R Pisegna
The voltage gated sodium channel SCN4A mutations account for non-dystrophic myotonia and include a heterogeneous group of conditions that include hyperkalemic periodic paralysis, paramyotonica congenita, potassium-aggravated myotonia, and hypokalemic periodic paralysis type 2. This case report proposes that a rare variant p.Pro1629Leu in SCN4A can cause a skeletal muscle deficit with intermittent dysphagia.
December 23, 2016: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28000293/do-kv-7-1-channels-contribute-to-control-of-arterial-vascular-tone
#10
Dmitry Tsvetkov, Mario Kaßmann, Jean-Yves Tano, Lan Chen, Johanna Schleifenbaum, Jakob Voelkl, Florian Lang, Yu Huang, Maik Gollasch
BACKGROUND AND PURPOSE: KV 7.1 voltage-gated potassium channels are expressed in vascular smooth muscle cells (VSMC) of diverse arteries, including mesenteric arteries. Based on pharmacological evidence using R-L3 (KV 7.1 channel opener), HMR1556, chromanol 293B (KV 7.1 channel blockers), stimulation of these channels has been suggested to evoke profound relaxation in various vascular beds of rats. However, the specificity of these drugs in vivo is uncertain. EXPERIMENTAL APPROACH: We used Kcnq1(-/-) mice and pharmacological tools to determine whether KV 7...
January 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27999123/early-alterations-of-hippocampal-neuronal-firing-induced-by-abeta42
#11
Daniela Gavello, Chiara Calorio, Claudio Franchino, Federico Cesano, Valentina Carabelli, Emilio Carbone, Andrea Marcantoni
We studied the effect of Amyloid β 1-42 oligomers (Abeta42) on Ca(2+) dependent excitability profile of hippocampal neurons. Abeta42 is one of the Amyloid beta peptides produced by the proteolytic processing of the amyloid precursor protein and participates in the initiating event triggering the progressive dismantling of synapses and neuronal circuits. Our experiments on cultured hippocampal network reveal that Abeta42 increases intracellular Ca(2+) concentration by 46% and inhibits firing discharge by 19%...
December 19, 2016: Cerebral Cortex
https://www.readbyqxmd.com/read/27994539/dynamic-control-of-neurotransmitter-release-by-presynaptic-potential
#12
REVIEW
Mickael Zbili, Sylvain Rama, Dominique Debanne
Action potentials (APs) in the mammalian brain are thought to represent the smallest unit of information transmitted by neurons to their postsynaptic targets. According to this view, neuronal signaling is all-or-none or digital. Increasing evidence suggests, however, that subthreshold changes in presynaptic membrane potential before triggering the spike also determines spike-evoked release of neurotransmitter. We discuss here how analog changes in presynaptic voltage may regulate spike-evoked release of neurotransmitter through the modulation of biophysical state of voltage-gated potassium, calcium and sodium channels in the presynaptic compartment...
2016: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/27990483/identification-of-novel-and-noninvasive-biomarkers-of-acute-cellular-rejection-after-liver-transplantation-by-protein-microarray
#13
Keita Okubo, Hiroshi Wada, Atsushi Tanaka, Hidetoshi Eguchi, Masahide Hamaguchi, Akira Tomokuni, Yoshito Tomimaru, Tadafumi Asaoka, Naoki Hama, Koichi Kawamoto, Shogo Kobayashi, Shigeru Marubashi, Hiroaki Nagano, Noriko Sakaguchi, Hiroyoshi Nishikawa, Yuichiro Doki, Masaki Mori, Shimon Sakaguchi
BACKGROUND: Acute cellular rejection (ACR) is one of the main factors in transplanted organ failure in liver transplantation. A precise marker for diagnosing or predicting rejection is not currently available; therefore, invasive liver biopsy is standard procedure. To develop a noninvasive method for precise diagnosis of ACR, we evaluated autoantibodies from patient sera as potential biomarkers using protein microarrays (seromics). METHODS: Sera from hepatitis C virus-positive ACR patients were compared to three hepatitis C virus cirrhosis control groups and healthy volunteers...
December 2016: Transplantation Direct
https://www.readbyqxmd.com/read/27933000/in-depth-study-of-the-interaction-sensitivity-and-gating-modulation-by-pufas-on-k-channels-interaction-and-new-targets
#14
REVIEW
Cristina Moreno, Alicia de la Cruz, Carmen Valenzuela
Voltage gated potassium channels (KV) are membrane proteins that allow selective flow of K(+) ions in a voltage-dependent manner. These channels play an important role in several excitable cells as neurons, cardiomyocytes, and vascular smooth muscle. Over the last 20 years, it has been shown that omega-3 polyunsaturated fatty acids (PUFAs) enhance or decrease the activity of several cardiac KV channels. PUFAs-dependent modulation of potassium ion channels has been reported to be cardioprotective. However, the precise cellular mechanism underlying the cardiovascular benefits remained unclear in part because new PUFAs targets and signaling pathways continue being discovered...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27932425/scn2b-deletion-in-mice-results-in-ventricular-and-atrial-arrhythmias
#15
Yangyang Bao, B Cicero Willis, Chad R Frasier, Luis F Lopez-Santiago, Xianming Lin, Roberto Ramos-Mondragón, David S Auerbach, Chunling Chen, Zhenxun Wang, Justus Anumonwo, Héctor H Valdivia, Mario Delmar, José Jalife, Lori L Isom
BACKGROUND: Mutations in SCN2B, encoding voltage-gated sodium channel β2-subunits, are associated with human cardiac arrhythmias, including atrial fibrillation and Brugada syndrome. Because of this, we propose that β2-subunits play critical roles in the establishment or maintenance of normal cardiac electric activity in vivo. METHODS AND RESULTS: To understand the pathophysiological roles of β2 in the heart, we investigated the cardiac phenotype of Scn2b null mice...
December 2016: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/27932254/investigating-possible-biological-targets-of-bj-crp-the-first-cysteine-rich-secretory-protein-crisp-isolated-from-bothrops-jararaca-snake-venom
#16
Marina E Lodovicho, Tássia R Costa, Carolina P Bernardes, Danilo L Menaldo, Karina F Zoccal, Sante E Carone, José C Rosa, Manuela B Pucca, Felipe A Cerni, Eliane C Arantes, Jan Tytgat, Lúcia H Faccioli, Luciana S Pereira-Crott, Suely V Sampaio
Cysteine-rich secretory proteins (CRISPs) are commonly described as part of the protein content of snake venoms, nevertheless, so far, little is known about their biological targets and functions. Our study describes the isolation and characterization of Bj-CRP, the first CRISP isolated from Bothrops jararaca snake venom, also aiming at the identification of possible targets for its actions. Bj-CRP was purified using three chromatographic steps (Sephacryl S-200, Source 15Q and C18) and showed to be an acidic protein of 24...
January 4, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/27928161/novel-kcnb1-mutation-associated-with-non-syndromic-intellectual-disability
#17
Xénia Latypova, Naomichi Matsumoto, Cécile Vinceslas-Muller, Stéphane Bézieau, Bertrand Isidor, Noriko Miyake
Potassium voltage-gated channel subfamily B member 1 (KCNB1) encodes Kv2.1 potassium channel of crucial role in hippocampal neuron excitation homeostasis. KCNB1 mutations are known to cause early-onset infantile epilepsy. To date, 10 KCNB1 mutations have been described in 11 patients. Using whole-exome sequencing, we identified a novel de novo missense (c.1132G>C, p.V378L) KCNB1 mutation in a patient with global developmental delay, intellectual disability, severe speech impairment, but no episode of epilepsy until the lastly examined age of 6 years old...
December 8, 2016: Journal of Human Genetics
https://www.readbyqxmd.com/read/27924669/effects-of-15%C3%A2-hz-square-wave-magnetic-fields-on-the-voltage-gated-sodium-and-potassium-channels-in-prefrontal-cortex-pyramidal-neurons
#18
Yu Zheng, Jun-Rong Dou, Yang Gao, Lei Dong, Gang Li
PURPOSE: Although magnetic fields have significant effects on neurons, little is known about the mechanisms behind their effects. The present study aimed to measure the effects of magnetic fields on ion channels in cortical pyramidal neurons. MATERIALS AND METHODS: Cortical pyramidal neurons of Kunming mice were isolated and then subjected to 15 Hz, 1 mT square wave (duty ratio 50%) magnetic fields stimulation. Sodium currents (INa), transient potassium currents (IA) and delayed rectifier potassium currents (IK) were recorded by whole-cell patch clamp method...
December 7, 2016: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/27922120/regulation-of-human-cardiac-potassium-channels-by-full-length-kcne3-and-kcne4
#19
Geoffrey W Abbott
Voltage-gated potassium (Kv) channels comprise pore-forming α subunits and a multiplicity of regulatory proteins, including the cardiac-expressed and cardiac arrhythmia-linked transmembrane KCNE subunits. After recently uncovering novel, N-terminally extended (L) KCNE3 and KCNE4 isoforms and detecting their transcripts in human atrium, reported here are their functional effects on human cardiac Kv channel α subunits expressed in Xenopus laevis oocytes. As previously reported for short isoforms KCNE3S and KCNE4S, KCNE3L inhibited hERG; KCNE4L inhibited Kv1...
December 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27919210/three-dimensional-modelling-of-the-voltage-gated-sodium-ion-channel-from-anopheles-gambiae-reveals-spatial-clustering-of-evolutionarily-conserved-acidic-residues-at-the-extracellular-sites
#20
Rithvik S Vinekar, Ramanathan Sowdhamini
The eukaryotic voltage-gated sodium channel(e-Nav) is a large asymmetric transmembrane protein with important functions concerning neurological function. No structure has been resolved at high resolution for this protein. A homology model of the transmembrane and extracellular regions of an Anopheles gambiae para-like channel with emphasis on the pore entrance has been constructed, based upon the templates provided by a prokaryotic sodium channel and a potassium two-pore channel. The latter provides a template for the extracellular regions, which are located above the entrance to the pore, which is likely to open at a side of a dome formed by these loops...
December 5, 2016: Current Neuropharmacology
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