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Biomarker microRNA

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https://www.readbyqxmd.com/read/28811385/circulating-mir-200c-is-up-regulated-in-paediatric-patients-with-familial-hypercholesterolaemia-and-correlates-with-mir-33a-b-levels-implication-of-a-zeb1-dependent-mechanism
#1
Marco D'Agostino, Francesco Martino, Sara Sileno, Francesco Barilla, Sara Beji, Lorenza Marchetti, Fabio Maria Gangi, Luca Persico, Mario Picozza, Anna Montali, Eliana Martino, Cristina Zanoni, Daniele Avitabile, Sandro Parrotto, Maurizio C Capogrossi, Alessandra Magenta
Hypercholesterolaemia provokes reactive oxygen species (ROS) increase and is a major risk factor for cardiovascular diseases (CVD) development. We previously showed that circulating microRNA(miR)-33a/b expression levels were up-regulated in children with familial hypercholesterolaemia (FH). miR-33a/b control cholesterol homoeostasis and recently miR-33b has been demonstrated to directly target the transcription factor ZEB1. The latter acts in a negative feedback-loop with miR-200 family. Our previous studies showed that the ROS-dependent miR-200c up-regulation induces endothelial dysfunction and provokes a ZEB1-dependent apoptosis and senescence...
August 15, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28810541/microrna-130a-is-highly-expressed-in-the-esophageal-mucosa-of-achalasia-patients
#2
Hiroyuki Shoji, Hajime Isomoto, Akira Yoshida, Haruo Ikeda, Hitomi Minami, Tsutomu Kanda, Shigetoshi Urabe, Kayoko Matsushima, Fuminao Takeshima, Kazuhiko Nakao, Haruhiro Inoue
Esophageal achalasia is considered as a risk factor of esophageal cancer. The etiologies of esophageal achalasia remain unknown. Peroral endoscopic myotomy (POEM) has recently been established as a minimally invasive method with high curability. The aims of the present study were to identify the microRNAs (miRs) specific to esophageal achalasia, to determine their potential target genes and to assess their alteration following POEM. RNA was extracted from biopsy samples from middle esophageal mucosa and analyzed using a microarray...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28809863/dynamic-plasma-micrornas-are-biomarkers-for-prognosis-and-early-detection-of-recurrence-in-colorectal-cancer
#3
Zixu Yuan, Kelsey Baker, Mary W Redman, Lei Wang, Scott V Adams, Ming Yu, Brandon Dickinson, Karen Makar, Neli Ulrich, Jürgen Böhm, Michelle Wurscher, Maria Westerhoff, Steve Medwell, Ravi Moonka, Mika Sinanan, Alessandro Fichera, Kathy Vickers, William M Grady
BACKGROUND: Plasma microRNAs (miRNAs) are promising non-invasive biomarkers for colorectal cancer (CRC) prognosis. However, the published studies to date have yielded conflicting and inconsistent results for specific plasma miRNAs. METHODS: We have conducted a study using robust assays to assess a panel of nine miRNAs for CRC prognosis and early detection of recurrence. Plasma samples from 144 patients in a prospective CRC cohort study were collected at diagnosis, 6, 12, and 24 months after diagnosis...
August 15, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28809371/the-role-of-micrornas-in-oral-lichenoid-disorders-systematic-review
#4
A Setién-Olarra, M-L Gainza-Cirauqui, J-M Aguirre-Urizar, X Marichalar-Mendia
BACKGROUND: Certain changes in the microRNA expression are considered to be associated with chronic inflammatory processes and with the malignant transformation of oral potentially malignant disorders. The purpose of this systematic review is to update the existing data on the aberrant microRNA expression profiles identified in oral lichenoid disease (OLD). MATERIAL AND METHODS: A search in PubMed-Medline and Scopus was performed on the English literature published between 2010 and August 2016 using the following keywords: oral lichenoid disease, oral lichen planus and microRNA...
August 15, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/28807026/circulating-micrornas-in-malaria-infection-bench-to-bedside
#5
REVIEW
Supat Chamnanchanunt, Suthat Fucharoen, Tsukuru Umemura
Severe malaria has a poor prognosis with a morbidity rate of 80% in tropical areas. The early parasite detection is one of the effective means to prevent severe malaria of which specific treatment strategies are limited. Many clinical characteristics and laboratory testings have been used for the early diagnosis and prediction of severe disease. However, a few of these factors could be applied to clinical practice. MicroRNAs (miRNAs) were demonstrated as useful biomarkers in many diseases such as malignant diseases and cardiovascular diseases...
August 15, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28806192/micrornas-as-biomarkers-in-chronic-kidney-disease
#6
Alexa Wonnacott, Timothy Bowen, Donald J Fraser
PURPOSE OF REVIEW: This review summarizes recent data supporting the concept that urinary microRNAs are a useful new class of biomarker. They may improve capacity to stratify patients with chronic kidney disease according to risk of progression, and may also inform about response to therapy. RECENT FINDINGS: MicroRNAs are present, stable and readily quantifiable in tissues and body fluids, including urine, and have widespread importance as regulators in the kidney...
August 12, 2017: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/28804551/a-tumor-suppressive-microrna-mirna-485-5p-inhibits-glioma-cell-proliferation-and-invasion-by-down-regulating-tpd52l2
#7
Jin Yu, Shi-Wen Wu, Wei-Ping Wu
Glioblastoma multiforme is the most deadly primary brain tumor and has no effective treatment. Therefore, it is important to identify novel and effective therapies that impede glioma tumorigenesis. MicroRNAs (miRNAs) are helpful analytical biomarkers and may be useful targets for treating multiple human cancers. Previous reports suggest that miRNA-485-5p is dysregulated and contributes to tumorigenesis in some cancer types. Nevertheless, the biological role of miRNA-485-5p in glioma is not well understood. In this study, we demonstrated that miRNA-485-5p expression was reduced in gliomat issues and cell lines...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28803886/a-method-for-extracting-and-characterizing-rna-from-urine-for-downstream-pcr-and-rnaseq-analysis
#8
Kun Zhou, Monique A Spillman, Kian Behbakht, Julia M Komatsu, Juan E Abrahante, Douglas Hicks, Brent Schotl, Evan Odean, Kenneth L Jones, Michael W Graner, Lynne T Bemis
Readily accessible samples such as urine or blood are seemingly ideal for differentiating and stratifying patients; however, it has proven a daunting task to identify reliable biomarkers in such samples. Noncoding RNA holds great promise as a source of biomarkers distinguishing physiologic wellbeing or illness. Current methods to isolate and characterize RNA molecules in urine are limited. In this proof of concept study, we present a method to extract and identify small noncoding RNAs in urine. Initially, quantitative reverse transcription PCR was applied to confirm the presence of microRNAs in total RNA extracted from urine...
August 10, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/28803540/preparation-of-highly-multiplexed-small-rna-sequencing-libraries
#9
Helena Persson, Rolf Søkilde, Anna Chiara Pirona, Carlos Rovira
MicroRNAs (miRNAs) are ~22-nucleotide-long small non-coding RNAs that regulate the expression of protein-coding genes by base pairing to partially complementary target sites, preferentially located in the 3´ untranslated region (UTR) of target mRNAs. The expression and function of miRNAs have been extensively studied in human disease, as well as the possibility of using these molecules as biomarkers for prognostication and treatment guidance. To identify and validate miRNAs as biomarkers, their expression must be screened in large collections of patient samples...
August 1, 2017: BioTechniques
https://www.readbyqxmd.com/read/28802022/microrna-492-overexpression-involves-in-cell-proliferation-migration-and-radiotherapy-response-of-cervical-squamous-cell-carcinomas
#10
Mei Liu, Jusheng An, Manni Huang, Liming Wang, Binbin Tu, Yan Song, Kai Ma, Yu Wang, Shuren Wang, Hongxia Zhu, Ningzhi Xu, Lingying Wu
MicroRNAs (miRNAs) are small non-coding RNA that target protein-coding mRNAs at the post-transcriptional level. The aim of this study was to define the role of miR-492 in cervical squamous cell carcinomas. After microRNA profiling and comparison, we firstly detected miR-492 expression in 104 tumor tissues biopsies derived from advanced staged (FIGO IIB-IIIB) cervical squamous cell carcinoma patients before receiving concomitant chemoradiotherapy and found miR-492 expression was significantly higher in the specimens that were sensitive to concomitant chemoradiotherapy, as compared with insensitive cancer specimens (p < 0...
August 12, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28800316/prognostic-significance-of-low-mir-144-expression-in-gastric-cancer
#11
Suoning Liu, Jian Suo, Chunxi Wang, Xuan Sun, Daguang Wang, Liang He, Yang Zhang, Wei Li
BACKGROUND: An overwhelming amount of evidence has emerged suggesting that dysregulated microRNAs (miRNAs) play crucial roles in tumorigenesis. OBJECTIVE: The study was to analyze tissue/serum miR-144 expression in gastric cancer and then evaluate their potential to predict the prognosis of gastric cancer. METHODS: We examined miR-144 levels in tissues and peripheral blood samples from 96 gastric cancer patients using real-time PCR. Then the association between tissue/serum miR-144 levels and clinicopathological parameters was determined...
July 2, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28798363/defining-quantification-methods-and-optimizing-protocols-for-microarray-hybridization-of-circulating-micrornas
#12
Anna Garcia-Elias, Leonor Alloza, Eulàlia Puigdecanet, Lara Nonell, Marta Tajes, Joao Curado, Cristina Enjuanes, Oscar Díaz, Jordi Bruguera, Julio Martí-Almor, Josep Comín-Colet, Begoña Benito
MicroRNAs (miRNAs) have emerged as promising biomarkers of disease. Their potential use in clinical practice requires standardized protocols with very low miRNA concentrations, particularly in plasma samples. Here we tested the most appropriate method for miRNA quantification and validated the performance of a hybridization platform using lower amounts of starting RNA. miRNAs isolated from human plasma and from a reference sample were quantified using four platforms and profiled with hybridization arrays and RNA sequencing (RNA-seq)...
August 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28797473/biomarker-research-to-improve-clinical-outcomes-of-peritoneal-dialysis-consensus-of-the-european-training-and-research-in-peritoneal-dialysis-eutripd-network
#13
REVIEW
Christoph Aufricht, Robert Beelen, Matthias Eberl, Michel Fischbach, Donald Fraser, Achim Jörres, Klaus Kratochwill, Manuel LópezCabrera, Peter Rutherford, Claus-Peter Schmitt, Nicholas Topley, Janusz Witowski
Peritoneal dialysis (PD) therapy substantially requires biomarkers as tools to identify patients who are at the highest risk for PD-related complications and to guide personalized interventions that may improve clinical outcome in the individual patient. In this consensus article, members of the European Training and Research in Peritoneal Dialysis Network (EuTRiPD) review the current status of biomarker research in PD and suggest a selection of biomarkers that can be relevant to the care of PD patients and that are directly accessible in PD effluents...
August 8, 2017: Kidney International
https://www.readbyqxmd.com/read/28796252/microrna-34-449-targets-igfbp-3-and-attenuates-airway-remodeling-by-suppressing-nur77-mediated-autophagy
#14
Huiming Yin, Shu Zhang, Yahong Sun, Sha Li, Yunye Ning, Yuchao Dong, Yan Shang, Chong Bai
Autophagy plays critical roles in airway inflammation and fibrosis-mediated airway remodeling and many factors including proinflammatory cytokines and inflammation related pathways are involved in the process. The aim of the present study was to examine the role of epithelial microRNAs (miRNAs) in autophagy-mediated airway remodeling and to identify the factors involved and the underlying mechanisms. Serum miR-34/449, inflammatory factors, and autophagy and fibrosis-related proteins were determined by real-time PCR, enzyme-linked immunosorbent assay and western blotting in 46 subjects with asthma and 10 controls and in the lung epithelial cell line BEAS-2B induced with IL-13 and treated with miRNA mimics...
August 10, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28795052/microrna-454-may-function-as-an-oncogene-via-targeting-akt-in-triple-negative-breast-cancer
#15
Qun Li, Jia Liu, Xianying Meng, Renzhu Pang, Jie Li
BACKGROUND: Altered microRNAs expression mediates tumor development and progression in many type cancers including triple negative breast cancer (TNBC). Here we detected the effect of miR-454 on cell proliferation, migration and invasion of triple negative breast cancer cells. RESULTS: miR-454 promoted the proliferation of TNBC, and enhanced migration and invasion in TNBC cells. Meanwhile, miR-454 improved the survival of TNBC cells after ironizing radiation. miR-454 inhibited radiation-induced apoptosis in TNBC cells by regulation of caspase 3/7 and Bcl-2 expression...
December 2017: Journal of Biological Research
https://www.readbyqxmd.com/read/28794294/upregulated-expression-of-circulating-micrornas-in-kidney-transplant-recipients-with-interstitial-fibrosis-and-tubular-atrophy
#16
Sepideh Zununi Vahed, Ahmad Poursadegh Zonouzi, Hossein Ghanbarian, Moteza Ghojazadeh, Nasser Samadi, Mohammadreza Ardalan
INTRODUCTION: The discovery of circulating microRNAs (miRNAs), as potential noninvasive diagnostic biomarkers, has opened new avenues of research for identifying transplant patients with chronic allograft dysfunction. The present study aimed to investigate the expression levels of 4 immune-related miRNAs, miR-21, miR-31, miR-142-3p, and miR-155, in plasma samples of kidney allograft recipients. MATERIALS AND METHODS: The plasma expression levels of the miRNAs were evaluated by quantitative real-time polymerase chain reaction in 53 kidney recipients with long-term stable allograft function (n = 27), biopsy-proven interstitial fibrosis and tubular atrophy (n = 26), and healthy controls (n = 15)...
July 2017: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/28792699/microrna-150-as-a-potential-biomarker-in-diagnosis-of-cancer-a-meta-analysis
#17
Jin Yan, Xuan Li, Lei Peng, Xiaoran Shen, Yini Dang, Guoxin Zhang
BACKGROUND: Altered expression of microRNAs contributes to human carcinogenesis. Previous studies assessed the association of aberrant circulating microRNA (miR)-150 level with the risk in developing various human cancers, but the data were inconsistent. METHODS: This meta-analysis further assessed the potential diagnostic value of miR-150 in cancer. PubMed, Embase, and Web of Science for publications were searched using the keywords of miR-150 and human cancer...
July 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28792262/ionizing-radiation-induced-altered-microrna-expression-as-biomarkers-for-assessing-acute-radiation-injury
#18
Vijay K Singh, Harvey B Pollard
No abstract text is available yet for this article.
August 9, 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/28791490/secretases-related-mirnas-in-alzheimer-s-disease-new-approach-for-biomarker-discovery
#19
REVIEW
Seyedeh Nazanin Hajjari, Mehdi Mehdizadeh, Saeed Sadigh-Eteghad, Dariush Shanehbandi, Shahram Teimourian, Behzad Baradaran
Amyloid-β (Aβ) as a crucial factor in pathogenesis of Alzheimer's disease (AD) is derived from amyloid precursor protein (APP) through a proteolytic process catalyzing by β- and γ-secretase-in amyloidogenesis pathway. Products of α-secretase cleavage also have protective effects against Aβ toxicity. According to existing evidences, microRNAs (miRNAs) show a unique pattern of expression in AD. Moreover, miRNAs regulatory effects on expression of secretases and their main components have been demonstrated in AD...
August 8, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28791400/microrna%C3%A2-744-inhibits-tumor-cell-proliferation-and-invasion-of-gastric-cancer-via-targeting-brain%C3%A2-derived-neurotrophic-factor
#20
Ai-Jun Xu, Li-Na Fu, Hua-Xing Wu, Xiao-Li Yao, Rui Meng
Gastric cancer is the fourth most common malignancy and the third leading cause of cancer‑associated deaths worldwide. It has previously been demonstrated that microRNAs (miRNAs) are actively involved in the pathogenesis of gastric cancer. Therefore, miRNAs have been proposed as promising therapeutic targets in gastric cancer patients. MiR‑744 is aberrantly expressed in different types of human cancer. However, the expression pattern and biological roles of miR‑744 in gastric cancer remain unknown. The present study demonstrated that miR‑744 expression was low in gastric cancer tissues and cell lines...
August 4, 2017: Molecular Medicine Reports
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