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post tuberculosis sequelae

Sahil Kulkarni, Sandeepan Mukherjee, Anupama Pandey, Ritwik Dahake, Usha Padmanabhan, Abhay S Chowdhary
OBJECTIVE: Japanese encephalitis (JE) is a debilitating disease caused by infection with the JE virus (JEV; family: Flaviviridae), which leaves neurological sequelae in survivors but more often leads to mortality. Neurodegeneration caused by inflammation is the primary pathology behind the clinical manifestation of encephalitis caused by JEV. Bacillus Calmette-Guérin (BCG) has been used in immunoprophylaxis for tuberculosis and in the adjuvant therapy of many malignancies, and has exhibited neuroprotective activities in experimental models of Parkinson and Alzheimer disease...
February 17, 2017: Neuroimmunomodulation
Muhammad Irfan
Tuberculosis (TB) is among the top infectious causes of morbidity and mortality worldwide and is associated with frequent pulmonary damage despite microbiological cure. Patients with treated TB may remain lifelong sufferers of disabling structural and functional sequelae of the disease, which subsequently impair quality of life. Long-term follow-up studies have revealed that many patients with treated pulmonary TB show signs of permanent impairment of their lung function. Impairment is variable in pattern and severity, ranging from none to severe, and shows restrictive, obstructive, or mixed patterns...
December 2016: International Journal of Mycobacteriology
Yves Tanauh, Flavien Kendja, Hervé Yangni-Angate, Blaise Demine, Raphaël Ouédé, Maurice Kouacou
BACKGROUND: To report and analyze noncardiac thoracic operations performed at the Cardiology Institute of Abidjan (Institut de Cardiologie d'Abidjan) from 1977 to 2015. METHODS: This is a retrospective and descriptive study covering 39 years, from 1977 to 2015. This study period was divided into three periods of 13 years each: P1 from 1977 to 1989, P2 from 1990 to 2002 and P3 from 2003 to 2015. Medical records of 2014 operated patients were analyzed: 414 patients for P1, 464 patients for P2, 1,136 patients for P3...
October 2016: Cardiovascular Diagnosis and Therapy
Ananya Panda, Ashu Seith Bhalla, Raju Sharma, Anant Mohan, Vishnu Sreenivas, Umasankar Kalaimannan, Ashish Dutt Upadhyay
AIMS: To study the correlation between dyspnea, radiological findings, and pulmonary function tests (PFTs) in patients with sequelae of pulmonary tuberculosis (TB). MATERIALS AND METHODS: Clinical history, chest computed tomography (CT), and PFT of patients with post-TB sequelae were recorded. Dyspnea was graded according to the Modified Medical Research Council (mMRC) scale. CT scans were analyzed for fibrosis, cavitation, bronchiectasis, consolidation, nodules, and aspergilloma...
November 2016: Lung India: Official Organ of Indian Chest Society
Marcela Muñoz-Torrico, Adrian Rendon, Rosella Centis, Lia D'Ambrosio, Zhenia Fuentes, Carlos Torres-Duque, Fernanda Mello, Margareth Dalcolmo, Rogelio Pérez-Padilla, Antonio Spanevello, Giovanni Battista Migliori
The role of tuberculosis as a public health care priority and the availability of diagnostic tools to evaluate functional status (spirometry, plethysmography, and DLCO determination), arterial blood gases, capacity to perform exercise, lesions (chest X-ray and CT), and quality of life justify the effort to consider what needs to be done when patients have completed their treatment. To our knowledge, no review has ever evaluated this topic in a comprehensive manner. Our objective was to review the available evidence on this topic and draw conclusions regarding the future role of the "post-tuberculosis treatment" phase, which will potentially affect several million cases every year...
September 2016: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
A Batirel, H Erdem, G Sengoz, F Pehlivanoglu, E Ramosaco, S Gülsün, R Tekin, B Mete, I I Balkan, D Y Sevgi, E Giannitsioti, A Fragou, S Kaya, B Cetin, T Oktenoglu, A D Celik, B Karaca, E S Horasan, M Ulug, S Senbayrak, S Kaya, E Arslanalp, R Hasbun, S Ates-Guler, A Willke, S Senol, D Inan, E Güclü, G T Ertem, M M Koc, M Tasbakan, G Ocal, S Kocagoz, H Kusoglu, T Güven, A I Baran, B Dede, F Y Karadag, H Yilmaz, G Aslan, D A Al-Gallad, S Cesur, R El-Sokkary, F Sirmatel, U Savasci, G Karaahmetoglu, H Vahaboglu
We aimed to describe clinical, laboratory, diagnostic and therapeutic features of spinal tuberculosis (ST), also known as Pott disease. A total of 314 patients with ST from 35 centres in Turkey, Egypt, Albania and Greece were included. Median duration from initial symptoms to the time of diagnosis was 78 days. The most common complications presented before diagnosis were abscesses (69%), neurologic deficits (40%), spinal instability (21%) and spinal deformity (16%). Lumbar (56%), thoracic (49%) and thoracolumbar (13%) vertebrae were the most commonly involved sites of infection...
November 2015: Clinical Microbiology and Infection
Alina Croitoru, Miron Alexandru Bogdan
Pulmonary rehabilitation represents a modern therapeutic approach of respiratory diseases, with a multidisciplinary character, including: physical training, therapeutic education, psychosocial counseling, and nutritional approach. Pulmonary rehabilitation addresses to any patient suffering from pulmonary pathology whose quality of life is affected by the respiratory symptoms, regardless of the degree of functional impairment. This article is an analysis of evidences from the medical literature on outcomes of rehabilitation programs conducted in various lung diseases...
April 2014: Pneumologia: Revista Societății Române de Pneumologie
Blandine Rammaert, Sophie Goyet, Arnaud Tarantola, Sopheak Hem, Sareth Rith, Sokleaph Cheng, Vantha Te, Patrich Lorn Try, Bertrand Guillard, Sirenda Vong, Charles Mayaud, Philippe Buchy, Laurence Borand
BACKGROUND: Little is known about post-infectious pulmonary sequelae in countries like Cambodia where tuberculosis is hyper-endemic and childhood pulmonary infections are highly frequent. We describe the characteristics of hospitalized Cambodian patients presenting with community-acquired acute lower respiratory infections (ALRI) on post-infectious pulmonary sequelae (ALRIPS). METHODS: Between 2007 and 2010, inpatients ≥15 years with ALRI were prospectively recruited...
October 2013: Respiratory Medicine
Elias Amorim, Roberto Saad, Roberto Stirbulov
OBJECTIVE: To evaluate pre and post-operative spirometry in patients with tuberculosis sequelae undergoing lobectomy. METHODS: We selected 20 patients, aged between 15 and 56 years, of both genders, with a history of tuberculosis treatment, with repeated infections or hemoptysis and indication of pulmonary lobectomy. The tuberculosis treatment time was six months, and onset of symptoms, between one and 32. We evaluated and compared vital capacity (VC), forced vital capacity (FVC), forced expiratory volume (FEV1), the FEV1/FVC, forced expiratory flow (FEF) and peak expiratory flow (PEF) preoperatively and after the first, third and sixth postoperative months (POM)...
March 2013: Revista do Colégio Brasileiro de Cirurgiões
Hun-Gyu Hwang, Ho-Sung Lee, Jae-Sung Choi, Ki-Hyun Seo, Yong-Hoon Kim, Ju-Ock Na
BACKGROUND: Hemoptysis due to pulmonary tuberculosis (TB) frequently develops in Korea where the prevalence of TB is intermediate. The effect of bronchial artery embolization (BAE) on the control of massive hemoptysis has been well known. This study is designed to identify the risk factors contributing to rebleeding after BAE in patients with TB. METHODS: We retrospectively evaluated risk factors and the time for rebleeding after BAE in 72 patients presenting with hemoptysis...
March 2013: Tuberculosis and Respiratory Diseases
Anant Mehrotra, Kuntal Kanti Das, Anup P Nair, Rajan Kumar, A K Srivastava, Rabi Narayan Sahu, Raj Kumar
INTRODUCTION: Tuberculosis (TB) of the cranio-vertebral junction (CVJ) is a rare condition, accounting for 0.3 % to 1 % of all cases of spinal TB. Early diagnosis and treatment are important in preventing long-term neurological sequelae. Management protocol of this rare site of TB is yet to be conclusively established. This holds particularly true for pediatric age group in which this condition is infrequently encountered. MATERIALS AND METHODS: A total of 29 consecutive pediatric patients presented to the Department of Neurosurgery at Sanjay Gandhi Post-Graduate Institute of Medical Sciences, Lucknow, from January 1997 to October2011 with clinical and/or radiological features suggestive of CVJ TB...
May 2013: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
François Spertini, Régine Audran, Floriana Lurati, Opokua Ofori-Anyinam, Frédéric Zysset, Pierre Vandepapelière, Philippe Moris, Marie-Ange Demoitié, Pascal Mettens, Carlota Vinals, Ilse Vastiau, Erik Jongert, Joe Cohen, W Ripley Ballou
UNLABELLED: Prevention of tuberculosis (TB) through vaccination would substantially reduce the global TB burden. Mtb72F/AS02 is a candidate TB vaccine shown to be immunogenic and well tolerated in PPD-negative adults. We evaluated the safety and immunogenicity of Mtb72F/AS02 in Mycobacterium-primed adults (BCG-vaccinated, or infected adults who had received post-exposure chemoprophylaxis or treatment for pulmonary TB disease). In this observer-blind controlled trial, 20 BCG-vaccinated adults and 18 adults previously infected with Mycobacterium tuberculosis (Mtb), were randomized 3:1 to receive three doses of Mtb72F/AS02 or AS02 at one-month intervals, and followed for 6 months post third vaccination...
March 2013: Tuberculosis
Gilbert Massard, Anne Olland, Nicola Santelmo, Pierre-Emmanuel Falcoz
This review describes diagnosis and management of sequelae of post-primary tuberculosis. It addresses elementary lesions such as bronciectasis, fibrostenosis, cavitation and broncholithiasis, the more complex situation of destroyed lung, and complications such as aspergilloma, hemoptysis and broncho-esophageal fistula.
August 2012: Thoracic Surgery Clinics
Y Toloba, S Diallo, Y Maiga, Bf Sissoko, K Ouattara, D Soumaré, S Sidibé
UNLABELLED: The spinal tuberculosis or Pott's disease is the most common form of osteoarticular tuberculosis in countries with high prevalence of tuberculosis and HIV / AIDS, but the definitive diagnosis remains difficult. The aim of this work was to study the epidemiological, clinical, radiological and evolutionary aspects of Pott's disease in the absence of evidence bacteriologically and histologically. METHOD: This is a retrospective study focused on records collected in the service of pneumo-phtisiology UHC of Point G, January 2005-December 2009...
2011: Le Mali Médical
Gulhan Cakır, Seyfettin Gumus, Ergun Ucar, Hatice Kaya, Ergun Tozkoparan, Emin Ozgur Akgul, Bulent Karaman, Omer Deniz, Ismail Kurt, Metin Ozkan, Hayati Bilgic
BACKGROUND: Chitotriosidase is an accepted marker of macrophage activation. In this study, we investigated serum chitotriosidase levels in pulmonary tuberculosis (PTB). METHODS: Forth-two patients with PTB and 30 healthy subjects were enrolled in the study. The radiological extent of PTB, radiological sequela after treatment, and the degree of smear positivity were assessed. Chitotriosidase levels were measured by a fluorometric method. RESULTS: The serum chitotriosidase levels of the PTB patients were significantly higher than those of the control subjects (39...
May 2012: Annals of Laboratory Medicine
Chandramohan Anuradha, N K Shyamkumar, Moses Vinu, N R S Surendra Babu, Devasahayam J Christopher
PURPOSE: To determine the long-term outcomes of bronchial artery embolization in patients with massive hemoptysis due to pulmonary tuberculosis and post-tuberculosis sequelae and to study the factors influencing success. MATERIALS AND METHODS: In this study, 58 patients underwent 64 bronchial artery embolizations for massive hemoptysis due to tuberculosis or its sequelae between 1998 and 2008. Their images and procedure details were reviewed. Medical records and direct contact were used to obtain information on outcome...
January 2012: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
B J M Ahui, K Horo, V C Brou-Gode, A B Kouassi, B Demine, J C Anon, S F Motsebo, E L Bemba, V H Achi, A S N'gom, N B Koffi, K Kendja, E Aka-Danguy
Multidrug resistance is defined as a resistance to two major antituberculosis drugs, which are isoniazid and rifampicin. The aim of the study was to specify the place of the thoracic surgery during the medical follow-up of the TB-MDR. Five files were kept over six years during this retrospective study. On the clinical and radiological level, localised lesions and a negative HIV serology were noted in the five patients. The completion date of the surgery varied between the third month and the 22nd after the beginning of the medical treatment...
June 2011: Revue de Pneumologie Clinique
V Dandavate, S Hira, C Oberai
Seventy-four consecutive patients with herpes zoster (HZ) in Mumbai were recruited into the study to determine its natural history. Thirty-five (47.3%) with HZ were infected with HIV-1/2. HZ+HIV+ and HZ+HIV- were demographically similar but HZ+HIV+ were clinically different; the latter were characterised by multidermatomal involvement of thoracic dermatomes below T6 or that of trigeminal nerve, recurrent episodes, bullous lesions and 17/35 had associated illnesses such as severe weight loss, recurrent fever, chronic cough, active tuberculosis and oral candidiasis...
July 1998: Indian Journal of Dermatology, Venereology and Leprology
Molly Roy, Stephen Ellis
Mycobacterium tuberculosis, the causal organism of tuberculosis (TB), is one of the oldest and still one of the deadliest pathogens known to man. Approximately 1 in 10 people with primary pulmonary tuberculosis (PTB) present clinically; of untreated cases, approximately 1 in 10 reactivate usually at a time of relative immunodeficiency. The spectrum of radiologic manifestations of PTB can pose a variety of diagnostic and management challenges. PTB infection often leaves long term sequelae of infection, particularly granulomatous nodules, cavitation, and fibrosis; distinguishing dormant disease from reactivation is not always clear-cut...
November 2010: Postgraduate Medical Journal
J Blaha, E Sansevicová, K Karpas, J Charvát
In the introduction the authors give an account of immunization against tuberculosis in post-war Czechoslovakia up to the present time from the aspect of the epidemiologist. After a 14-year interval the authors evaluate the results of the investigation and treatment of children with osseous complication after immunization with the BCG vaccine type Moscow. The group comprises four children who were hospitalized years ago at the Orthopaedic Clinic in Hradec Králové for assessment of the diagnosis and initiation of comprehensive treatment...
1995: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
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