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https://www.readbyqxmd.com/read/29017172/the-emerging-roles-of-cib1-in-cancer
#1
Xianwang Wang, Xiaochun Peng, Xueqing Zhang, Hanyi Xu, Chengbiao Lu, Lian Liu, Jiaxing Song, Yingjie Zhang
Calcium and integrin-binding protein 1 (CIB1) is an EF-hand calcium binding protein, which is involved in many cellular processes, including calcium signaling, cell survival and proliferation, cell migration, cell adhesion and apoptosis. A number of studies have found that CIB1 is ubiquitously expressed and is related to various human diseases, such as cancer, Alzheimer's disease (AD), cardiac hypertrophy and male infertility. The mechanism of CIB1 in human diseases is still not clear, although multiple functions of CIB1 are modulated by interacting with numerous interacting partners...
October 11, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28992374/male-accessory-gland-inflammation-infertility-and-sexual-dysfunctions-a-practical-approach-to-diagnosis-and-therapy
#2
REVIEW
A E Calogero, Y Duca, R A Condorelli, S La Vignera
The role of urogenital inflammation in causing infertility and sexual dysfunctions has long been a matter of debate in the international scientific literature. The most recent scientific evidences show that male accessory gland infection/inflammation could alter, with various mechanisms, both conventional and biofunctional sperm parameters, and determine worst reproductive outcome. At the same time, the high prevalence of erectile dysfunction and premature ejaculation in patients with male accessory gland infection/inflammation underlines the close link between these diseases and sexual dysfunctions...
October 9, 2017: Andrology
https://www.readbyqxmd.com/read/28924382/linker-histone-in-diseases
#3
REVIEW
Xin Ye, ChuanLin Feng, Tian Gao, Guanqun Mu, Weiguo Zhu, Yang Yang
The linker histone is a protein that binds with the nucleosome, which is generally considered to achieve chromatin condensation in the nucleus. Accumulating evidences suggest that the linker histone is essential in the pathogenesis of several diseases. In this review, we briefly introduce the current knowledge of the linker histone, including its structure, characteristics and functions. Also, we move forward to present the advances of the linker histone's association with certain diseases, such as cancer, Alzheimer's disease, infection, male infertility and aberrant immunity situations, focusing on the alteration of the linker histone under certain pathological conditions and its role in developing each disease...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28892594/male-infertility-the-other-side-of-the-equation
#4
Darren J Katz, Patrick Teloken, Ohad Shoshany
BACKGROUND: A male factor contributes to infertility in approximately 50% of couples who fail to conceive, causing significant psychosocial and marital stress. OBJECTIVE: This article reviews the general practitioner's (GP's) evaluation of male infertility and indications for referral to a male infertility specialist, and gives an overview of the specialist management of male infertility. DISCUSSION: Male infertility can result from anatomical or genetic abnormalities, systemic or neurological diseases, infections, trauma, iatrogenic injury, gonadotoxins and development of sperm antibodies...
September 2017: Australian Family Physician
https://www.readbyqxmd.com/read/28838078/mycoplasma-genitalium-in-women-current-knowledge-and-research-priorities-for-this-recently-emerged-pathogen
#5
REVIEW
Harold C Wiesenfeld, Lisa E Manhart
Health consequences of sexually transmitted diseases disproportionately affect women, making it important to determine whether newly emerged pathogens cause sequelae. Although the pathogenic role of Mycoplasma genitalium in male urethritis is clear, fewer studies have been conducted among women to determine its pathogenic role in the female reproductive tract. Pelvic inflammatory disease (PID) is an important cause of infertility and ectopic pregnancy, and Chlamydia trachomatis and Neisseria gonorrhoeae are recognized microbial causes...
July 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28746835/genetic-ataxia-telangiectasia-porcine-model-phenocopies-the-multisystemic-features-of-the-human-disease
#6
Rosanna Beraldi, David K Meyerholz, Alexei Savinov, Attila D Kovács, Jill M Weimer, Jordan A Dykstra, Ryan D Geraets, David A Pearce
Ataxia telangiectasia (AT) is a progressive multisystem autosomal recessive disorder caused by mutations in the AT-mutated (ATM) gene. Early onset AT in children is characterized by cerebellar degeneration, leading to motor impairment. Lung disease and cancer are the two most common causes of death in AT patients. Accelerated thymic involution may contribute to the cancer, and recurrent and/or chronic respiratory infections may be a contributing factor to lung disease in AT. AT patients have fertility issues, are highly sensitive to ionizing radiation and they present oculocutaneous telangiectasia...
November 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28723470/sexually-transmitted-disease-and-male-infertility-a-systematic-review
#7
REVIEW
Mikkel Fode, Ferdinando Fusco, Larry Lipshultz, Wolfgang Weidner
CONTEXT: Theoretically, sexually transmitted diseases (STDs) have the potential to disrupt male fertility; however, the topic remains controversial. OBJECTIVE: To describe the possible association between STDs and male infertility and to explore possible pathophysiologic mechanisms. EVIDENCE ACQUISITION: We performed a systematic literature review in accordance with the PRISMA guidelines. PubMed, Embase, and the Cochrane Library were searched for articles published before January 1, 2016, using the MeSH terms for a variety of STDs and infertility...
October 2016: European Urology Focus
https://www.readbyqxmd.com/read/28701755/microbiota-composition-of-the-koala-phascolarctos-cinereus-ocular-and-urogenital-sites-and-their-association-with-chlamydia-infection-and-disease
#8
Miranda E Vidgen, Jonathan Hanger, Peter Timms
Disease caused by Chlamydia pecorum is characterised by ocular and urogenital infections that can lead to blindness and infertility in koalas. However, koalas that are infected with C. pecorum do not always progress to disease. In other host systems, the influence of the microbiota has been implicated in either accelerating or preventing infections progressing to disease. This study investigates the contribution of koala urogenital and ocular microbiota to Chlamydia infection and disease in a free ranging koala population...
July 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28697346/-necrozoospermia-from-etiologic-diagnosis-to-therapeutic-management
#9
A Dumont, A-L Barbotin, V Lefebvre-Khalil, V Mitchell, J-M Rigot, F Boitrelle, G Robin
This review describes necrospermia, its diagnosis, causes and management. Sperm vitality is commonly assessed in the laboratory of reproductive biology, with the eosin test or with the hypo-osmotic swelling test. Necrospermia is defined by a percentage of living spermatozoa inferior to 58%, and can be related to male infertility. Several pathological mechanisms may be involved and can be classified either in testicular causes (hyperthyroidism, local hyperthermia, varicocele), or post-testicular causes (epididymal necrospermia, dysregulation of seminal plasma, adult polycystic kidney disease, vasectomy reversal, anti-sperm antibodies) or both (infection, toxic, age, spinal cord injury)...
April 2017: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/28597829/urogenital-infection-as-a-risk-factor-for-male-infertility
#10
Hans-Christian Schuppe, Adrian Pilatz, Hamid Hossain, Thorsten Diemer, Florian Wagenlehner, Wolfgang Weidner
BACKGROUND: Infections of the genital tract are considered common causes of male fertility disorders, with a prevalence of 6-10%. Most of the affected men are asymptomatic. The diagnostic evaluation is based mainly on laboratory testing. Inconsistent diagnostic criteria have been applied to date, and this may explain the controversial debate about the role of infection and inflammation in the genital tract as a cause of infertility. The risk of an irreversible fertility disorder should not be underestimated...
May 12, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28482843/sero-prevalence-of-specific-leptospira-serovars-in-fattening-pigs-from-5-provinces-in-vietnam
#11
Hu Suk Lee, Nguyen Viet Khong, Huyen Nguyen Xuan, Vuong Bui Nghia, Hung Nguyen-Viet, Delia Grace
BACKGROUND: Leptospirosis is a zoonotic bacterial disease with a worldwide distribution. In Vietnam, leptospirosis is considered endemic. In pigs, leptospirosis can result in reproductive problems (such as abortion and infertility) which lead to economic loss. In addition, transmission to people presents a public health risk. In Vietnam, few national studies have been conducted on sero-prevalence of leptospirosis in pigs. The main objective of this study was to evaluate the sero-prevalence and incidence of presumptive infective leptospira serovars in fattening pigs from 5 provinces in Vietnam...
May 8, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28225805/prevalence-and-risk-factors-of-chlamydia-infection-in-hong-kong-a-population-based-geospatial-household-survey-and-testing
#12
William Chi Wai Wong, Yanping Zhao, Ngai Sze Wong, William L Parish, Heidi Yin Hai Miu, Li-Gang Yang, Michael Emch, King Man Ho, Francois Yeung Fong, Joseph D Tucker
BACKGROUND: Chlamydia causes infertility and increases risk of HIV infection, and population-based studies provide essential information for effective infection control and prevention. This study examined Chlamydia trachomatis prevalence and risk factors among a representative sample of 18-49-year-old residents in Hong Kong. METHODS: Census boundary map of 412 constituency areas was used as primary sampling units to construct the sampling frame and, residential buildings and units were randomly selected using geospatial modelling...
2017: PloS One
https://www.readbyqxmd.com/read/28086915/comparative-study-in-infertile-couples-with-and-without-chlamydia-trachomatis-genital-infection
#13
COMPARATIVE STUDY
Yuanchang Zhu, Biao Yin, Tonghua Wu, Lijun Ye, Chunmei Chen, Yong Zeng, Yaou Zhang
BACKGROUND: Chlamydia, caused by the bacterium Chlamydia trachomatis(C. trachomatis), is the most common sexually transmitted disease. The incidence is not clear due to the asymptomatic nature of early stage of infections. The incidence of Chlamydia has not been fully investigated in the Chinese Han population. Since chronic infection with can C. trachomatis can lead to infertility in males and females, it is important to determine the impact of infection on clinical outcomes. The aim of this study is to explore the epidemiology of C...
January 13, 2017: Reproductive Health
https://www.readbyqxmd.com/read/27916649/new-horizons-for-cystic-fibrosis-treatment
#14
REVIEW
Isabelle Fajac, Kris De Boeck
Cystic fibrosis is an inherited multi-system disease associated with chronic lung infection, malabsorption, salt loss syndromes, male infertility and leading to numerous comorbidities. The landscape in cystic fibrosis care has changed markedly with currently more adult patients than children in many countries. Over 2000 different mutations in the CFTR gene have been reported and the majority are extremely rare. Understanding how CFTR mutations translate to disturbed synthesis or function of the CFTR protein has opened the way to 'personalized' treatments to correct the basic defect...
February 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27816924/men-s-knowledge-of-their-own-fertility-a-population-based-survey-examining-the-awareness-of-factors-that-are-associated-with-male-infertility
#15
D Daumler, P Chan, K C Lo, J Takefman, P Zelkowitz
STUDY QUESTION: How knowledgeable are men about the medical, environmental and psychological factors that are associated with male infertility? SUMMARY ANSWER: Men, across most demographic groups, have limited knowledge of the various factors that are associated with male infertility. WHAT IS KNOWN ALREADY: Few surveys have focused on men's knowledge of their own fertility. Studies of both men and women have found that men are comparatively less knowledgeable about issues of fertility and reproductive health...
December 2016: Human Reproduction
https://www.readbyqxmd.com/read/27609978/specific-immune-cell-and-cytokine-characteristics-of-human-testicular-germ-cell-neoplasia
#16
Britta Klein, Thomas Haggeney, Daniela Fietz, Sivanjah Indumathy, Kate L Loveland, Mark Hedger, Sabine Kliesch, Wolfgang Weidner, Martin Bergmann, Hans-Christian Schuppe
STUDY QUESTION: Which immune cells and cytokine profiles are characteristic for testicular germ cell neoplasia and what consequences does this have for the understanding of the related testicular immunopathology? SUMMARY ANSWER: The unique immune environment of testicular germ cell neoplasia comprises B cells and dendritic cells as well as high transcript levels of IL-6 and other B cell supporting or T helper cell type 1 (Th1)-driven cytokines and thus differs profoundly from normal testis or inflammatory lesions associated with hypospermatogenesis...
October 2016: Human Reproduction
https://www.readbyqxmd.com/read/27583786/increased-gonorrhea-cases-utah-2009-2014
#17
Joanna Watson, Jerry Carlile, Angela Dunn, Megan Evans, Erin Fratto, Joel Hartsell, Lynn Meinor, Matthew Mietchen, Allyn Nakashima
Gonorrhea (caused by infection with Neisseria gonorrhoeae) is the second most commonly reported notifiable disease in the United States (1). Left untreated, gonorrhea is associated with serious long-term adverse health effects, including pelvic inflammatory disease, ectopic pregnancy, and infertility. Infection also facilitates transmission of human immunodeficiency virus (2,3). Effective gonorrhea control relies upon early detection and effective antimicrobial treatment. To assess gonorrhea rate trends in Utah, the Utah Department of Health (UDOH) analyzed Utah National Electronic Disease Surveillance System (UT-NEDSS) data for the state during 2009-2014...
September 2, 2016: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/27486990/host-nectin-1-promotes-chlamydial-infection-in-the-female-mouse-genital-tract-but-is-not-required-for-infection-in-a-novel-male-murine-rectal-infection-model
#18
Jessica A Slade, Jennifer V Hall, Jennifer Kintner, Regenia Phillips-Campbell, Robert V Schoborg
Chlamydia trachomatis is the most common bacterial sexually transmitted pathogen, but more than 70% of patients fail to seek treatment due to the asymptomatic nature of these infections. Women suffer from numerous complications from chronic chlamydial infections, which include pelvic inflammatory disease and infertility. We previously demonstrated in culture that host cell nectin-1 knockdown significantly reduced chlamydial titers and inclusion size. Here, we sought to determine whether nectin-1 was required for chlamydial development in vivo by intravaginally infecting nectin-1-/- mice with Chlamydia muridarum and monitoring chlamydial shedding by chlamydial titer assay...
2016: PloS One
https://www.readbyqxmd.com/read/27486783/mutations-in-dnajb13-encoding-an-hsp40-family-member-cause-primary-ciliary-dyskinesia-and-male-infertility
#19
Elma El Khouri, Lucie Thomas, Ludovic Jeanson, Emilie Bequignon, Benoit Vallette, Philippe Duquesnoy, Guy Montantin, Bruno Copin, Florence Dastot-Le Moal, Sylvain Blanchon, Jean François Papon, Patrick Lorès, Li Yuan, Nathalie Collot, Sylvie Tissier, Catherine Faucon, Gérard Gacon, Catherine Patrat, Jean Philippe Wolf, Emmanuel Dulioust, Bruno Crestani, Estelle Escudier, André Coste, Marie Legendre, Aminata Touré, Serge Amselem
Primary ciliary dyskinesia (PCD) is an autosomal-recessive disease due to functional or ultra-structural defects of motile cilia. Affected individuals display recurrent respiratory-tract infections; most males are infertile as a result of sperm flagellar dysfunction. The great majority of the PCD-associated genes identified so far encode either components of dynein arms (DAs), which are multiprotein-ATPase complexes essential for ciliary motility, or proteins involved in DA assembly. To identify the molecular basis of a PCD phenotype characterized by central complex (CC) defects but normal DA structure, a phenotype found in ∼15% of cases, we performed whole-exome sequencing in a male individual with PCD and unexplained CC defects...
August 4, 2016: American Journal of Human Genetics
https://www.readbyqxmd.com/read/27353336/the-role-of-dendritic-cells-in-male-reproductive-tract
#20
REVIEW
Peng Wang, Yong-Gang Duan
Dendritic cells (DCs) are the most potent professional antigen-presenting cells. The central role of various DC subsets as bridges between innate and adaptive immunity has become more and more evident. However, the role of DC subsets in male reproductive tract remains largely unexplored, in particular distinct DC subsets (including myeloid and plasmacytoid DCs), their maturation stage, and tissue distribution, as well as state of health or disease. Furthermore, infection and inflammation of male genital tract are thought to be a primary etiological factor of male infertility...
September 2016: American Journal of Reproductive Immunology: AJRI
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