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Diabete type 1

J Liang, Y Zhu, X-K Liu, Q-Q Qiu, Y-T Sun, Y Wang, Y Pei, M-Q Yang, L Qi
BACKGROUND: Obesity is strongly associated with insulin resistance and elevated plasma glucose levels. The rs9356744 polymorphism in the CDKAL1 gene is associated with body mass index (BMI) only in East Asians. Here, we examined the effect of the rs9356744 polymorphism on glucose-related traits and prediabetes in Chinese adults. METHODS: A total of 2 357 participants were enrolled from the Cardiometabolic Risk in Chinese (CRC) Study, including 499 persons with prediabetes, 204 persons with type 2 diabetes, and 1 654 normoglycemic controls...
June 22, 2018: Experimental and Clinical Endocrinology & Diabetes
Hriday Bera, Sanoj Kumar, Sabyasachi Maiti
Olive oil-entrapped diethanolamine-modified high-methoxyl pectin (DMP)-gellan gum (GG)-bionanofiller composites were developed for controlled intragastric delivery of metformin HCl (MFM). DMP had a degree of amidation of 48.7% and was characterized further by FTIR, XRD and DSC analyses. MFM-loaded composites were subsequently accomplished by green synthesis via ionotropic gelation technique using zinc acetate as cross-linker. The thermal, X-ray and infrared analyses suggested an environment in the composites compatible with the drug, except certain degree of attenuation in drug's crystallinity...
June 19, 2018: International Journal of Biological Macromolecules
Sunil S Gupta, Kavita S Gupta, Sachin S Gathe, Parvinder Bamrah, Shlok S Gupta
BACKGROUND: Lipohypertrophy (LH) at insulin injection sites is a common but preventable complication in type 1 diabetes mellitus (T1DM). We evaluated the prevalence, contributing risk factors, and consequences of LH, specifically the glycemic variability (GV) among T1DM patients. METHODS: This is a cross-sectional study conducted at a tertiary care center in India, wherein 139 subjects with T1DM were randomly selected and evaluated for the presence of LH through visual and palpation examinations...
June 22, 2018: Diabetes Technology & Therapeutics
Paula Perry Hampton, Jerell D Chua, Emily Johnson, Barbara J Edlund
The purpose of this study was to improve healthcare outcomes by reducing blood pressure and weight in adult patients with diabetes at afederally qualified health center. NextGen electronic health record was used to review aggregate data of blood pressures and weight pre-intervention and post-intervention for women and men (N = 304) between 20 and 87 years of age with type 2 diabetes and a BMI : 30. Findings from this study showed that blood pressure and weight did not improve as anticipated using a variety of educational approaches and strategies within the study population...
July 2017: Journal of National Black Nurses' Association: JNBNA
So Jin Lee, Min-Gul Kim, Shin-Jung Park, Ji-Young Jeon
OBJECTIVE: This study was conducted to evaluate the pharmacokinetics and bioequivalence of two formulations of -DuvieTM (0.5-mg lobeglitazone sulfate). MATERIALS AND METHODS: This study was designed as an open-label, randomized, single-dose, crossover bioequivalence study in healthy male subjects. A total of 28 subjects were randomized into two groups: one group received the test drug, 0.5-mg DuvieTM tablets, which have formulations available on the global market; and the other group received the reference drug, the initially-approved 0...
June 22, 2018: International Journal of Clinical Pharmacology and Therapeutics
Alireza Ghardashi Afousi, Mohammad Reza Izadi, Kamran Rakhshan, Farnoosh Mafi, Soheil Biglari, Habibalah Gandomkar Bagheri
NEW FINDINGS: What is the central question of this study? Endothelial function is impaired because of increased oscillatory and retrograde shear in patients with type 2 diabetes. It is unclear whether low-volume high-intensity interval training and continuous moderate intensity exercise can modulate oscillatory and retrograde shear, blood flow and flow-mediated arterial dilation in these patients. What is the main finding and its importance? We found that low-volume high-intensity interval training, by increasing anterograde shear and decreasing retrograde shear and oscillatory index, can increase nitric oxide production and consequently result in increased flow-mediated dilation and outward arterial remodelling in patients with type 2 diabetes...
June 22, 2018: Experimental Physiology
Rhianna M Tuchscherer, Angela M Thompson, Jennifer M Trujillo
OBJECTIVE: To review efficacy and safety of the glucagon-like peptide-1 receptor agonist (GLP-1 RA) semaglutide for type 2 diabetes (T2D). DATA SOURCES: A literature search of PubMed/MEDLINE and EMBASE using the term semaglutide was completed through April 2018. A search of was also conducted. STUDY SELECTION AND DATA EXTRACTION: English-language studies assessing the efficacy and/or safety of semaglutide were evaluated...
June 1, 2018: Annals of Pharmacotherapy
Agata Chobot, Katarzyna Górowska-Kowolik, Magdalena Sokołowska, Przemysława Jarosz-Chobot
Diabetes (DM) as well as obesity, due to their increasing incidence, were recognized as epidemic by the World Health Organization (WHO). Obesity is not only involved in the etiopathogenesis of the most common worldwide type of DM - type 2 diabetes (T2D), but also in the development of its complications. There is also increasing scientific evidence regarding the role of obesity and overweight in type 1 diabetes (T1D). Weight gain may be considered as a complication of insulin treatment, but also reveals significant pathophysiological impact on various stages of the disease...
June 21, 2018: Diabetes/metabolism Research and Reviews
M Mrgan, J Gram, M Hecht Olsen, D Dey, B Linde Nørgaard, J Gram, N P Rønnow Sand
AIM: To determine differences in coronary plaque composition and inflammatory biomarkers between men and women with newly diagnosed Type 2 diabetes without known cardiovascular disease. METHODS: A total of 88 people with newly diagnosed (<1 year) Type 2 diabetes underwent contrast-enhanced coronary computed tomography angiography. Advanced coronary plaque analysis was performed using semi-automated software. Plasma concentrations of inflammatory biomarkers were determined...
June 22, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
R Perera, N Oliver, E Wilmot, C Marriott
Since the introduction of real-time continuous glucose monitoring (CGM) systems more than 15 years ago and, more recently, flash glucose monitoring (Flash-GM), clinical studies have observed reductions in HbA1c , independent of insulin delivery method, with decreasing time spent in hypoglycaemia [1] and reduction in glycaemic variability [2]. CGM can improve quality of life and reduce diabetes-related distress [3], including fear of hypoglycaemia [4,5]. Despite these benefits, CGM has yet to be fully implemented as part of the standard of care for people living with Type 1 diabetes in England, and there is considerable variation in how it is funded through local payer organizations...
June 22, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
Judith J Stephenson, Amit D Raval, David M Kern, Jay P Bae
To assess insulin nonadherence among patients with type 2 diabetes (T2DM) to better understand relationships between adherence, basal insulin (BI) usage, and patient experiences. METHODS: A cross-sectional survey of patients with T2DM using BI was conducted. Adherence was measured by Morisky Medication Adherence Scale 8-Items (MMAS-8). Low adherence (LA) was defined as MMAS-8 score <6; high adherence (HA) as MMAS-8 score = 8; and medium adherence as MMAS-8 score = 6-7. Patients with MMAS-8 scores = 6-7 were excluded from the analysis...
June 21, 2018: Diabetes, Obesity & Metabolism
Véronique Gingras, Lisa Bonato, Virginie Messier, Amélie Roy-Fleming, Mohamed Raef Smaoui, Martin Ladouceur, Rémi Rabasa-Lhoret
AIMS: To examine the effect of added protein and/or fat in standard meals with a fixed carbohydrate content on postprandial glucose control with closed-loop insulin delivery in adults with type 1 diabetes. MATERIALS AND METHODS: In this randomized four-way cross-over study, participants (n=15) consumed breakfast meals with a fixed carbohydrate content (75±1 g) and added protein and/or fat (35±2 g): 1) carbohydrate-only (standard), 2) high protein (HP), 3) high fat (HF) and 4) high fat + protein meals (HFHP)...
June 21, 2018: Diabetes, Obesity & Metabolism
Y S Van den Berkhof, C M Gant, R Maatman, A De Graaf, G J Navis, S J L Bakker, G D Laverman
BACKGROUND: Renal function decline in diabetic kidney disease is accompanied by calcium and phosphate metabolism alterations. Whereas Strontium (Sr2+ ) has many similarities with calcium, little is known about Sr2+ in this respect. We studied the association of plasma Sr2+ concentration and parameters associated with an altered calcium and phosphate metabolism in diabetic kidney disease. MATERIALS AND METHODS: Plasma Sr2+ concentration was measured in 450 patients included in the DIAbetes and LifEstyle Cohort Twente-1...
June 21, 2018: European Journal of Clinical Investigation
José Sérgio Nascimento Silva, Isly Maria Lucena de Barros, Fabiano Lima Cantarelli, Rodrigo Cantarelli Alves, Felipe José de Andrade Falcão, Josefa Martinelly Dos Santos Silva, Flávio Roberto Azevedo de Oliveira, Rodrigo Pinto Pedrosa
To verify the frequency and predictors associated with stent thrombosis (ST) in a developing country. Observational, case-control study including 2535 consecutive patients undergoing percutaneous coronary intervention (PCI) in two reference hospitals in Brazil, from October 2013 to December 2015. ST patients were matched to controls in a 1:3 ratio for gender, age, procedure indication, and performing hospital. From the total sample, 65 (2.5%) ST occurred and were matched with 195 controls (age 64.9 ± 11...
June 21, 2018: Journal of Thrombosis and Thrombolysis
Richard Silbert, Alejandro Salcido-Montenegro, Rene Rodriguez-Gutierrez, Abdulrahman Katabi, Rozalina G McCoy
PURPOSE OF REVIEW: Hypoglycemia is the most common and often treatment-limiting serious adverse effect of diabetes therapy. Despite being potentially preventable, hypoglycemia in type 2 diabetes incurs substantial personal and societal burden. We review the epidemiology of hypoglycemia in type 2 diabetes, discuss key risk factors, and introduce potential prevention strategies. RECENT FINDINGS: Reported rates of hypoglycemia in type 2 diabetes vary widely as there is marked heterogeneity in how hypoglycemia is defined, measured, and reported...
June 21, 2018: Current Diabetes Reports
May Sanyoura, Louis H Philipson, Rochelle Naylor
PURPOSE OF REVIEW: We provide a review of monogenic diabetes in young children and adolescents with a focus on recognition, management, and pharmacological treatment. RECENT FINDINGS: Monogenic forms of diabetes account for approximately 1-2% of diabetes in children and adolescents, and its incidence has increased in recent years due to greater awareness and wider availability of genetic testing. Monogenic diabetes is due to single gene defects that primarily affect beta cell function with more than 30 different genes reported...
June 22, 2018: Current Diabetes Reports
Tomoe Kinoshita, Masashi Shimoda, Junpei Sanada, Yoshiro Fushimi, Yurie Hirata, Shintaro Irie, Atsushi Obata, Tomohiko Kimura, Hidenori Hirukawa, Kenji Kohara, Fuminori Tatsumi, Shinji Kamei, Shuhei Nakanishi, Tomoatsu Mune, Kohei Kaku, Hideaki Kaneto
INTRODUCTION: Sodium-glucose co-transporter 2 (SGLT2) inhibitors function not only to reduce hyperglycemia but also to ameliorate liver injury and reduce body weight. The aim of this study was to examine in which subjects SGLT2 inhibitors are more effective for glycemic control, liver injury, and obesity in Japanese subjects with type 2 diabetes mellitus. METHODS: We enrolled a total of 156 subjects with type 2 diabetes who initiated SGLT2 inhibitor treatment after September 1, 2014 in Kawasaki Medical School (Protocol No...
June 21, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
Der-Ming Chang, Wei-Jei Lee, Jung-Chien Chen, Kong-Han Ser, Pei-Ling Tsai, Yi-Chih Lee
BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) has been validated as a safe and effective treatment for morbid obesity. However, data of the long-term outcome remains lacking. METHODS: A total of 1759 LSG was performed as primary bariatric procedure from 2005 to 2017 with mean age of 35.2 ± 10.3 years old (14-71), female 69.7%, mean body mass index (BMI) 37.9 ± 7.7 kg/m2 , and mean waist width 113.7 ± 17.9 cm. All patients were evaluated and managed under a strict multidisciplinary team approach...
June 21, 2018: Obesity Surgery
Marjan Mansourian, Akram Yazdani, Elham Faghihimani, Ashraf Aminorraya, Masoud Amini, Tohid Jafari-Koshki
AIMS: Pre-diabetes is a strong risk factor for type 2diabetes (T2D). The aim of this study was to explore factors associated with normal glucose maintenance and pre-diabetes prevention or delay. METHODS: Data of 1016 first-degree relatives of T2D patients were retrieved from the Isfahan Diabetes Prevention Study (IDPS). Association of various variables including nutrients, serum tests and physical activity with the risk of pre-diabetes was assessed using recurrent events approach...
June 22, 2018: Eating and Weight Disorders: EWD
Nazila Kassaian, Awat Feizi, Ashraf Aminorroaya, Parvaneh Jafari, Maryam Tajabadi Ebrahimi, Masoud Amini
AIMS: Probiotics and/or prebiotics could be a promising approach to improve metabolic disorders by favorably modifying the gut microbial composition. OBJECTIVES: To assess the effects of probiotics and synbiotic on glycemic indices in prediabetic individuals who are at risk of type 2 diabetes and its complications. METHODS: In a double-blind, randomized, placebo-controlled parallel-group clinical trial, 120 prediabetic adults participated and were randomly allocated to receive either probiotics or synbiotic or placebo supplements for 24 weeks...
June 22, 2018: Acta Diabetologica
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